Interrelationships In The Variability Of Root Canal Anatomy Among The Permanent Teeth: A Full-Mouth Approach By Cone-Beam Ct., 2017 University of the Pacific
Interrelationships In The Variability Of Root Canal Anatomy Among The Permanent Teeth: A Full-Mouth Approach By Cone-Beam Ct., Paul Monsarrat, Bertrand Arcaute, Ove A. Peters, Elisabeth Maury, Norbert Telmon, Marie Georgelin-Gurgel, Delphine Maret
OBJECTIVES: In endodontic practice, clinicians should be aware of possible root canal anatomic variations. The aim of this study was to assess using CBCT acquisitions regarding whether one root canal anatomy of a tooth is associated with a specific anatomy of another tooth.
METHODS: A total of 106 CBCT acquisitions were obtained using a CBCT scanner with 200μm voxel size. Numbers of roots and canals of the entire dentition were described. Bivariate analyses and logistic regressions were conducted to explore root canal anatomy on one tooth according to age, gender, jaw, side and the others teeth. Multiple correspondence analysis (MCA ...
Effect Of Voxel Size On The Accuracy Of 3d Reconstructions With Cone Beam Ct., 2017 University of the Pacific
Effect Of Voxel Size On The Accuracy Of 3d Reconstructions With Cone Beam Ct., Delphine Maret, Norbert Telmon, Ove A. Peters, B. Lepage, J. Treil, J. M. Inglèse, A. Peyre, Jean-Luc Kahn, Michel Sixou
OBJECTIVES: The various types of cone beam CT (CBCT) differ in several technical characteristics, notably their spatial resolution, which is defined by the acquisition voxel size. However, data are still lacking on the effects of voxel size on the metric accuracy of three-dimensional (3D) reconstructions. This study was designed to assess the effect of isotropic voxel size on the 3D reconstruction accuracy and reproducibility of CBCT data. METHODS: The study sample comprised 70 teeth (from the Institut d'Anatomie Normale, Strasbourg, France). The teeth were scanned with a KODAK 9500 3D® CBCT (Carestream Health, Inc., Marne-la-Vallée, France), which has two ...
Educational Outcomes Of Small-Group Discussion Versus Traditional Lecture Format In Dental Students' Learning And Skills Acquisition., Ana Arias, Raymond Scott, Ove A. Peters, Elizabeth Mcclain, Alan H. Gluskin
The aim of this prospective quantitative study was to compare the effect of different instructional formats on dental students' skills and knowledge acquisition for access cavity preparation. All first-year dental students were invited to participate in this study conducted during the four consecutive two-week endodontic rotation courses at the University of the Pacific Arthur A. Dugoni School of Dentistry in spring semester 2015. Four alphabetically distributed intact groups of students were randomly allocated to two groups (n=70 each) that participated in either small-group discussion or a traditional lecture on access preparation. The first outcome measure was skill acquisition, measured ...
Biological Markers For Pulpal Inflammation: A Systematic Review., 2017 University of the Pacific
Biological Markers For Pulpal Inflammation: A Systematic Review., Dan-Krister Rechenberg, Johnah C. Galicia, Ove A. Peters
BACKGROUND AND OBJECTIVE: Pulpitis is mainly caused by an opportunistic infection of the pulp space with commensal oral microorganisms. Depending on the state of inflammation, different treatment regimes are currently advocated. Predictable vital pulp therapy depends on accurate determination of the pulpal status that will allow repair to occur. The role of several players of the host response in pulpitis is well documented: cytokines, proteases, inflammatory mediators, growth factors, antimicrobial peptides and others contribute to pulpal defense mechanisms; these factors may serve as biomarkers that indicate the status of the pulp. Therefore, the aim of this systematic review was to ...
Advances In Endodontics: Potential Applications In Clinical Practice., 2017 University of the Pacific
Advances In Endodontics: Potential Applications In Clinical Practice., Anil Kishen, Ove A. Peters, Matthias Zehnder, Anibal R. Diogenes, Madhu K. Nair
Contemporary endodontics has seen an unprecedented advance in technology and materials. This article aimed to review some of the challenges and advances in the following sections: (1) endodontic imaging, (2) root canal preparation, (3) root canal disinfection, (4) root canal filling, and (4) regenerative endodontic procedures (REPs). Jointly, these advances are aimed at improving the state of the art and science of root canal treatment.
Contact Point, 2017 University of the Pacific
Contact Point, Arthur A. Dugoni School Of Dentistry
No abstract provided.
Mesenchymal Stem Cell (Msc) Spheroid Constructs Containing Microfluidic Bmp2-Plga Microcapsules In Bone Tissue Engineering., 2017 University of Pennsylvania
Mesenchymal Stem Cell (Msc) Spheroid Constructs Containing Microfluidic Bmp2-Plga Microcapsules In Bone Tissue Engineering., Bhavendrasinh Sayania
Recombinant human bone morphogenetic protein-2 (rhBMP-2) is a clinically available osteogenic growth factor. In its current form, approved for clinical use, however, the growth factor is delivered in excessively high doses, resulting in unpredictable bone growth and unwanted clinical side effects. In this study, we evaluated a novel system, slow-release hybrid delivery system for PLGA- rhBMP-2 microcapusles in combination with BM MSC spheroids, and assess if it can lead to improved BMP-derived bone formation. The first aim of this study is to evaluate the osteogenicity of 3D cell spheroids as compared to 2D cultured cells, as we used primary cells ...
The Unbearable Emptiness Of Tweeting—About Journal Articles, 2017 Georgia Institute of Technology - Main Campus
The Unbearable Emptiness Of Tweeting—About Journal Articles, Nicolas Robinson Garcia, Rodrigo Costas, Kimberley Isett, Julia Melkers, Diana Hicks
The Role Of Mas-Related G-Protein Receptor X2 (Mrgprx2) On Neuropeptide Induced Reponses In Human Mast Cells, 2017 University of Pennsylvania School of Dental Medicine
The Role Of Mas-Related G-Protein Receptor X2 (Mrgprx2) On Neuropeptide Induced Reponses In Human Mast Cells, Wichayapha Manorak
Rationale: Substance P (SP) and hemokinin-1 (HK-1) are neuropeptides (NPs) that promote inflammatory responses by signaling through the neurokinin-1 receptor (NK-1R). Antagonists of NK-1R are highly effective in allergic inflammation and airway hyperresponsiveness in mice but lack efficacy in humans. The reason for this difference is unknown. Human mast cells express both the NK-1R and Mas-related G protein receptor X2 (MRGPRX2) which are both activated by SP. The objective of this study was to determine if HK-1 activates human mast cells via MRGPRX2. Moreover, since MRGPRX2 contains a cholesterol recognition amino acid consensus (CRAC) domain the interaction between MRGPRX2 and ...
P2x7 Receptor Primes Il-1Β And The Nlrp3 Inflammasome In Astrocytes Subjected To Mechanical Strain, 2017 University of Pennsylvania
P2x7 Receptor Primes Il-1Β And The Nlrp3 Inflammasome In Astrocytes Subjected To Mechanical Strain, Farraj S. Albalawi, Wennan Lu, Jonarhan M. Beckel, Jason C. Lim, Stuart A. Mccaughey, Claire H. Mitchell
Inflammatory responses play a key role in many neural pathologies, with localized signaling from non-immune cells making critical contributions. The NLRP3 inflammasome is an important component of innate immune signaling and can link neural insult to chronic inflammation. Stimulation of the NLRP3 inflammasome is a two-stage process. The priming stage involves upregulation of the biosynthesis of the structural components while activation results in their assembly into the actual inflammasome complex and subsequent activation. The priming step can be rate limiting and can connect insult to chronic inflammation but our knowledge of the signals that regulate NLRP3 inflammasome priming in sterile ...
Prospective, Comparative Assessment Of Alveolar Ridge Preservation Using Guidor® Easy-Graft® Classic In Atrumatic Extraction Socket, Kelsey S. Tengan
Theses and Dissertations
Objectives: Tooth extraction initiates a cascade of biological events leading to the reduction of alveolar ridge volume. Alveolar ridge preservation (ARP) is a surgical treatment which aims at minimizing hard and soft tissue changes following tooth extraction. Several techniques and materials have been studied and used clinically in ARP. The selection of the biomaterials used for this technique is determined by several factors, such as features of the extraction site, inherent biomaterial properties and handling preferences by the surgeon, among others. The purpose of this study was to evaluate the efficacy of alveolar ridge preservation via the application of Easy-graft ...
Cumulative Trauma, Emotion Reactivity And Salivary Cytokine Response Following Acute Stress Among Healthy Women., 2017 University of Louisville
Cumulative Trauma, Emotion Reactivity And Salivary Cytokine Response Following Acute Stress Among Healthy Women., Yvette Z. Szabo
Electronic Theses and Dissertations
This study furthers understanding of how trauma exposure may be connected to the development and maintenance of poor health by focusing on cytokines, tightly regulated proteins of the immune system. Cytokine responses to acute stress have been associated with the onset of poorer mental health in physically healthy women. The present study examined how two factors recently associated with cytokine reactivity –cumulative trauma and emotion reactivity– are associated with salivary cytokine reactivity among healthy women. Seventy-one women, screened to be physically and mentally healthy, completed a laboratory acute stress paradigm and self-report measures of state emotion and trauma exposure. Participants ...
Periodontal Phenotype And Supracrestal Soft Tissue Dimensions – Clinical Correlations And Their Impact On Post-Extraction Volumetric Changes, Sarah Rinehart
Theses and Dissertations
Extraction of a tooth leads to a series of healing events that are intimately associated with dimensional changes in the alveolar ridge that typically result in a net volume loss. Previous studies have evaluated the extent and pattern of those resorptive changes, however it remains challenging to predict the degree of change that will occur, as numerous local and systemic factors may play a role in the biologic events that follow tooth extraction. The purpose of this study was to assess the role that phenotypic characteristics of the periodontium play in the alveolar ridge remodeling processes that take place ...
Idiopathic Condylar Resorption: The Current Understanding In Diagnosis And Treatment, 2017 University of the Pacific
Idiopathic Condylar Resorption: The Current Understanding In Diagnosis And Treatment, Andrew L. Young
Andrew L. Young
Idiopathic condylar resorption (ICR) is a condition with no known cause, which manifests as progressive malocclusion, esthetic changes, and often pain. Cone‑beam computed tomography and magnetic resonance imaging are the most valuable imaging methods for diagnosis and tracking, compared to the less complete and more distorted images provided by panoramic radiographs, and the higher radiation of 99mtechnetium‑methylene diphosphonate. ICR has findings that overlap with osteoarthritis, inflammatory arthritis, physiologic resorption/remodeling, congenital disorders affecting the mandible, requiring thorough image analysis, physical examination, and history‑taking. Correct diagnosis and determination of whether the ICR is active or inactive are ...
Caries Classification, 2017 CUNY Hostos Community College
Caries Classification, Diana V. Macri, Annie Chitlall
Publications and Research
It has been 10 years since Featherstone and colleagues presented their evidence-based model of caries management: caries management by risk assessment (CAMBRA). This approach relies on a careful analysis of a patients’ risk factors and protective factors. International and national organizations have long recognized the need for a new caries classification system that incorporates evidence-based approaches to halt progression of caries lesions and minimize the need for surgical intervention. Thus, the International Caries Detection and Assessment System (ICDAS) and the American Dental Association Caries Classification System (ADA CCS) were created. The purpose of this article is to briefly review the ...
Effects Of Palatal Expansion On Speech Production, 2017 Marquette University
Effects Of Palatal Expansion On Speech Production, Jason Milton Meinhardt
Master's Theses (2009 -)
Introduction: Rapid palatal expanders (RPEs) are a commonly used orthodontic adjunct for the treatment of posterior crossbites. RPEs are cemented to bilateral posterior teeth across the palate and thus may interfere with proper tongue movement and linguopalatal contact. The purpose of this study was to identify what specific role RPEs have on speech sound production for the child and early adolescent orthodontic patient. Materials and Methods: RPEs were treatment planned for patients seeking orthodontics at Marquette University. Speech recordings were made using a phonetically balanced reading passage (“The Caterpillar”) at 3 time points: 1) before RPE placement; 2) immediately after ...
Effects Of Mechanical Stretch On Stem Cells From Human Exfoliated Deciduous Teeth (Shed), 2017 University of Pennsylvania
Effects Of Mechanical Stretch On Stem Cells From Human Exfoliated Deciduous Teeth (Shed), Katherine Zhang
No abstract provided.
Establishment Of Innovative Shared Departments To Advance Interdisciplinary Education, 2017 University of New Haven
Establishment Of Innovative Shared Departments To Advance Interdisciplinary Education, Ronald S. Harichandran, Brian Kench, Summer Mcgee, Michael A. Collura, Jean Nocito-Gobel, Charles David Skipton
Engineering and Applied Science Education Faculty Publications
More and more universities are pursuing interdisciplinary academic activities that span across department and college boundaries. Administrative structures to facilitate such programs are difficult to establish within traditional university frameworks consisting of disciplinary departments and colleges. Often interdisciplinary programs are housed in a traditional disciplinary department or college, or in a standalone center reporting to a college dean or the provost. The difficulty of these structures is obtaining broad buy-in from faculty across departments and having disciplinary degree programs include interdisciplinary coursework.
To overcome the difficulties described above, an innovative shared department structure that fosters collaborations to advance interdisciplinary education ...
Periodontal Ligament And Gingival Fibroblasts Participate In The Production Of Tgf-Β, Interleukin (Il)-8 And Il-10, 2017 University of São Paulo
Periodontal Ligament And Gingival Fibroblasts Participate In The Production Of Tgf-Β, Interleukin (Il)-8 And Il-10, Ana Carolina Morandini, Carla Renata Sipert, Erivan Schnaider Ramos-Junior, Daniel Thomas Brozoski, Carlos Ferreira Santos
Ana Carolina Morandini
The aim of this study was to quantify and compare the production of transforming growth factor beta (TGF-β), interleukin (IL)-8 and IL-10 by human cultured periodontal ligament and gingival fibroblasts both obtained from the same donors challenged with lipopolysaccharide (LPS) from Porphyromonas gingivalis. Fibroblasts were exposed to 0.1-10 µg/mL of LPS from P. gingivalis and after 24 h the supernatants were collected and analyzed by enzyme-linked immunosorbent assay (ELISA). TGF-β protein production was upregulated in a concentration-dependent manner, mainly in gingival fibroblasts, which was statistically significant when challenged by 10 µg/mL LPS. Additionally, at this concentration ...
Palatal Mucosa Derived Fibroblasts Present An Adaptive Behavior Regarding Cytokine Secretion When Grafted Onto The Gingival Margin, Fabíola Pontes Azevedo, Ana Carolina Morandini, Carla Renata Sipert, Thiago José Dionísio, Carlos Ferreira Santos, Carla Andreotti Damante, Maria Lúcia Rubo De Rezende, Adriana Campos Passanezi Sant'ana, Sebastião Luiz Aguiar Greghi
Ana Carolina Morandini
BACKGROUND: Considering that grafted gingival tissue might have to be adapted to the receptor area and that fibroblasts have the ability to respond to bacterial stimuli through the release of various cytokines, this study investigated whether fibroblasts from the palatal mucosa behave differently when grafted onto the gingival margin regarding cytokine secretion. METHODS: Biopsies from the palatal mucosa were collected at the time of free gingival graft surgery, and after four months re-collection was performed upon surgery for root coverage. Fibroblasts were isolated by the explant technique, cultured and stimulated with Porphyromonas gingivalis (Pg) and Escherichia coli (Ec) LPS for ...