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Analyzing The Regionalized Awareness Of Distraction Osteogenesis, Ali Weinzapfel 2016 Western Kentucky University

Analyzing The Regionalized Awareness Of Distraction Osteogenesis, Ali Weinzapfel

Honors College Capstone Experience/Thesis Projects

There are multiple treatment options available to initiate bone growth within the oral cavity. Distraction osteogenesis is a surgical dental procedure performed to initiate new bone growth in the maxillofacial region. This procedure is an important advancement to dental professionals because of the minimal complications and great outcome of bone growth it offers. As dentistry is always evolving, it is imperative to relay current trends to other professionals within the field of dentistry. The goal of this research was to analyze the regionalized awareness of distraction osteogenesis. A survey was conducted among dentists in Kentucky and Tennessee with multiple questions ...


The Implementation Of Alternative Pain Control Methods By Dental Hygienists, Alejandra Valadez Rodriguez 2016 Western Kentucky University

The Implementation Of Alternative Pain Control Methods By Dental Hygienists, Alejandra Valadez Rodriguez

Honors College Capstone Experience/Thesis Projects

As a dental hygienist, it is important to understand new concepts and techniques that can contribute to a more comfortable setting for patients who experience dental anxiety. Alternative pain control methods can assist in alleviating patient anxiety, therefore, providing a more efficient and relaxed clinical atmosphere for both patient and clinician. Some of the methods discussed are: guided imagery, deep breathing, muscle relaxation, hypnosis, acupressure, essential oil diffusion, audio distraction, and visual stimuli. After reviewing the literature the researcher found that dental anxiety affects patient compliance, their overall health, and willingness to attend regular dental visits. The purpose of this ...


Dentin Remineralization Around Ceramir Restoration, Lujain S. Alhuwayrini 2016 University of Pennsylvania

Dentin Remineralization Around Ceramir Restoration, Lujain S. Alhuwayrini

Dental Theses

AIM:

To determine the efficacy of Ceramir, a modified glass ionomer cement and a surfactant mono-n-dodecyl phosphate in remineralization of dentin around root caries restorations.

MATERIALS & METHODS:

45 permanent intact teeth were embedded in self-cured dental acrylic resin to expose buccal or lingual surfaces. The buccal/lingual surfaces were wet ground with carbide paper, final polishing were accomplished with aluminum to obtain highly polished dentin surface. Baseline Knoop micro hardness values were recorded. All specimens were then etched using 37% phosphoric acid for 5 seconds to demineralize dentin and to expose dentin collagen. The Knoop indenter micro hardness measurements were ...


Get In The Zone: A Survey Of Dental Professionals' Knowledge Of Ozone Therapy, Emily Hannah 2016 Western Kentucky University

Get In The Zone: A Survey Of Dental Professionals' Knowledge Of Ozone Therapy, Emily Hannah

Honors College Capstone Experience/Thesis Projects

Ozone therapy has been used in medicine for many years to treat a variety of ailments. Ozone is an unstable triatomic molecule made up of three oxygen atoms. This molecule has the ability to kill bacteria, fungi, parasites, and viruses. The researcher first was curious if there has been research done on uses of Ozone Therapy in the dental setting. After reviewing the literature there is indeed a use for Ozone Therapy to treat a host of dental problems including periodontal disease, ulcers, and carious lesions (also known as cavities). However, there are conflicting conclusions in the literature as to ...


Novel Endodontic Disinfection Approach Using Nanotechnology, Sarah Bukhari, Bekir Karabucak, Hyun Koo 2016 University of Pennsylvania

Novel Endodontic Disinfection Approach Using Nanotechnology, Sarah Bukhari, Bekir Karabucak, Hyun Koo

Dental Theses

The aim of this in vitro investigation was to use a recently developed Enterococcus faecalis infection model using root canal for evaluating iron oxide (Fe3O4) nanoparticles (NP) with biomimetic (catalytic) properties as a new antimicrobial endodontic treatment. We compared iron oxide NP bioactivity with currently used chemical modalities using confocal laser scanning microscopy (CLSM) and scanning electron microscopy (SEM) as analytical tools.

We hypothesized that iron oxide NP with enzyme-­like (peroxidase) activity catalyzes H2O2 to promote bacterial killing within dentinal tubules (DT) via in situ production of free radicals. We further hypothesized that the NP is more effective than ...


The Requirement Of P53 In Oral Msc Differentiation Which Leads To Kaposi’S Sarcoma, May Alsenani 2016 University of Pennsylvania

The Requirement Of P53 In Oral Msc Differentiation Which Leads To Kaposi’S Sarcoma, May Alsenani

Dental Theses

P53 is considered one of the most important defense proteins against cancer.Although the p53 mutation is associated with many cancers, its mutation is never found in Kaposi’s sarcoma (KS), raising a possibility that functional p53 may play a role in KS development. To assess the role of p53 in Kaposi’s sarcoma tumor, shRNA-mediated gene silencing was used to knockdown p53 expression. We examined Kaposi’s sarcoma-associated herpesvirus (KSHV)-infected periodontal ligaments stem cells (PDLSC) for osteogenic differentiation and endothelial angiogenesis, and we observed noticeable decreases in osteogenic differentiation and angiogenesis when p53 expression was knocked down in ...


The Advanced Dental Hygiene Practitioner: An Exploration Of The Patient Perspective Regarding The Advancement Of A Mid-Level Dental Provider, Jacqueline M. Burgess 2016 East Tennessee State Universtiy

The Advanced Dental Hygiene Practitioner: An Exploration Of The Patient Perspective Regarding The Advancement Of A Mid-Level Dental Provider, Jacqueline M. Burgess

Electronic Theses and Dissertations

The purpose of this study was to examine patient attitudes and opinions regarding the advancement of a mid-level dental provider, such as the ADHP, in an effort to better understand the perceptions of those who may one day be in a position to receive care from this type of provider. In this quantitative study, I analyzed the differences between those with and without access to dental care and evaluated differences among respondents based upon their socioeconomic and demographic attributes. I collected data from patients treated at Mt. Juliet Family & Cosmetic Dentistry and at the Coweta Samaritan Clinic via a 17-item ...


Managing Peri-Implantitis, Namita Khandelwal 2016 University of New England

Managing Peri-Implantitis, Namita Khandelwal

Dental Medicine Faculty Publications

This guide, used by MetLife for its dental continuing education program, focuses on the inflammatory pathology around dental implants. It outlines the risk factors and diagnostic criteria for peri-implantitis, an inflammatory process resulting in progressive loss of bone around the implant. The guide also provides treatment approaches for peri-implantitis, including surgical and non-surgical options.


Peptoanaerobacter Stomatis Interactions With Neutrophils., Emeri Jimenez Flores 2016 University of Louisville

Peptoanaerobacter Stomatis Interactions With Neutrophils., Emeri Jimenez Flores

Electronic Theses and Dissertations

Peptoanaerobacter stomatis is a newly appreciated taxon, present in high numbers in oral biofilms from periodontal patients. However, little is known about this organism’s potential virulence and its interaction with the host immune response. Therefore, to better understand the role of P. stomatis in periodontitis, we studied its interactions with neutrophils. Human neutrophils were challenged with P. stomatis strain CM2 or S. aureus AF488 (positive control) for 30 min. Bacterial internalization was examined by ImageStreamX imaging flow cytometry. Bacterial viability was assessed by colony-forming unit assays and Baclight assays. Phagocytosis-stimulated respiratory burst response was measured by flow cytometry. The ...


Characterization Of Pg1604 (Porz) As An Essential Component Of Type 9 Secretion System In Porphyromonas Gingivalis., Apurva Tadimari Prabhakar 2016 University of Louisville

Characterization Of Pg1604 (Porz) As An Essential Component Of Type 9 Secretion System In Porphyromonas Gingivalis., Apurva Tadimari Prabhakar

Electronic Theses and Dissertations

Background: The numerous virulence factors of Porphyromonas gingivalis are essential for the organism to invade host tissues while escaping immune responses [1, 2]. Some of these factors, like major proteases referred to as gingipains, are secreted by a unique secretion system called PerioGate or Type IX Secretion System (T9SS). T9SS consists of a number of membrane and periplasmic proteins, which provide transportation only for proteins that possess a conserved C-terminal domain (CTD). The CTD functions as a specific recognition signal for the T9SS. PG1604 of P. gingivalis W83 is a CTD-containing protein, which has been shown in our initial studies ...


Rankl From Osteocytes Contributes To Periodontal Bone Loss, Ahmed Alshabab 2016 University of Pennsylvania School of Dental Medicine

Rankl From Osteocytes Contributes To Periodontal Bone Loss, Ahmed Alshabab

Dental Theses

Periodontal bone loss results from bacterial infection and the associated host response. The ligand for the receptor activator of NF-κB (RANKL) induces the differentiation of osteoclasts, resulting in periodontal bone loss. The role of osteocytes in periodontal bone loss was investigated in this study. Transgenic mice expressing RANKL under the control of dentin matrix protein 1 (DMP1) were infected with Porphyromonas gingivalis- Fusobacterium nucleatum bacteria (Pg-Fn) to induce periodontitis, and type 1 diabetes was induced in groups of mice. Control (DMP1­Cre.RANKLf/f) mice with periodontal infection showed increases in bone loss, osteoclast counts, eroded bone surfaces, and ...


Transcriptome Analysis Of B Cell Immune Functions In Periodontitis: Mucosal Tissue Responses To The Oral Microbiome In Aging, Jeffrey L. Ebersole, Sreenatha S. Kirakodu, Michael John Novak, Luis Orraca, Janis Gonzalez-Martinez, Larry Cunningham Jr., Mark V. Thomas, Arnold J. Stromberg, Subramanya N. Pandruvada, Octavio A. Gonzalez 2016 University of Kentucky

Transcriptome Analysis Of B Cell Immune Functions In Periodontitis: Mucosal Tissue Responses To The Oral Microbiome In Aging, Jeffrey L. Ebersole, Sreenatha S. Kirakodu, Michael John Novak, Luis Orraca, Janis Gonzalez-Martinez, Larry Cunningham Jr., Mark V. Thomas, Arnold J. Stromberg, Subramanya N. Pandruvada, Octavio A. Gonzalez

Center for Oral Health Research Faculty Publications

Evidence has shown activation of T and B cells in gingival tissues in experimental models and in humans diagnosed with periodontitis. The results of this adaptive immune response are noted both locally and systemically with antigenic specificity for an array of oral bacteria, including periodontopathic species, e.g., Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. It has been recognized through epidemiological studies and clinical observations that the prevalence of periodontitis increases with age. This report describes our studies evaluating gingival tissue transcriptomes in humans and specifically exploiting the use of a non-human primate model of naturally occurring periodontitis to delineate gingival mucosal ...


The Effect Of Orthodontic Appliances On The Evaluation Of The Professionalism And Esthetics Of An Adult Employee, Laura Hanson Vaccariello 2016 Marquette University

The Effect Of Orthodontic Appliances On The Evaluation Of The Professionalism And Esthetics Of An Adult Employee, Laura Hanson Vaccariello

Master's Theses (2009 -)

This study explored the influence of fixed and removable orthodontic appliances on participants’ ratings of the job performance, intelligence, and attractiveness of an adult female. Ninety-four adult subjects were recruited from the Graduate School of Management at Marquette University. Each subject received an identical employee performance review with an attached photograph of a female employee. The smile of the photo was manipulated to represent one of four conditions: no orthodontic appliance, a metal orthodontic appliance, a ceramic orthodontic appliance, or a clear aligner. Subjects then rated the employee on three continuous Likert scales. Ratings of job performance, intelligence, and attractiveness ...


The Effects Of Mechanical Vibration On Human Chondrocytes In Vitro, Bradley J. Gauthier 2016 Marquette University

The Effects Of Mechanical Vibration On Human Chondrocytes In Vitro, Bradley J. Gauthier

Master's Theses (2009 -)

Introduction: Inflammation is the biological basis of temporomandibular joint disorders (TMD), when severe it can lead to osteoarthritis. One of the physical therapies used to manage this condition is mechanical vibration, as has been used in medicine for many years as a non-pharmacological therapy. Recently an FDA approved dental device called AcceleDent has been introduced to increase the rate of tooth movement and decrease pain. As the device-generated vibration transmits to the TMJ, it is important for us to investigate whether mechanical vibration influences TMJ on its biologic basis – chondrocytes under normal and inflammatory conditions. Materials and Methods: Human chondrocyte ...


The Effect Of Mechanical Vibration On Human Pdl Cell Differentiation And Response To Inflammation, Megan DesRoches 2016 Marquette University

The Effect Of Mechanical Vibration On Human Pdl Cell Differentiation And Response To Inflammation, Megan Desroches

Master's Theses (2009 -)

Low magnitude mechanical vibration is a therapeutic adjunct being investigated to alter bone remodeling and inflammation in areas such as osteoporosis, bone fracture healing, and muscle soreness after exercise. In orthodontics a device named AcceleDent has been marketed that claims to increase the rate of tooth movement and decrease pain. However evidence for these claims is lacking. In this study we looked at two potential cellular mechanisms for these claims: periodontal ligament (PDL) cell differentiation and inflammation under an orthodontic model of strain (IL-1β). Increased PDL cell differentiation into osteogenic cells could be an avenue of increasing orthodontic tooth movement ...


Mechanical Properties Of Copper-Nickel-Titanium Archwires, Margaret Amelia Rosen 2016 Marquette University

Mechanical Properties Of Copper-Nickel-Titanium Archwires, Margaret Amelia Rosen

Master's Theses (2009 -)

Introduction: The initial phase of orthodontic therapy relies on flexible wires, usually composed of a nickel-titanium alloy, to apply a substantially constant load during tooth movement. Copper has been added to nickel-titanium archwires, resulting in an alloy with potential clinical advantages such as a lower stress hysteresis. Many orthodontic companies claim that their copper-nickel-titanium manufacturing process allows for the production of more consistent transition temperatures in the wires, allowing the orthodontist to customize treatment to various patients based on the force level needed. There are currently many manufacturers of these wires, creating a wide range of copper-nickel-titanium archwires from which ...


Microfluidic Plga Microcapsules For The Sustained Delivery Of Recombinant Human Bone Morphogenetic Protein 2 In 3d Printed Pcl/Βtcp Scaffolds, Sara M. Kasten 2016 University of Pennsylvania School of Dental Medicine

Microfluidic Plga Microcapsules For The Sustained Delivery Of Recombinant Human Bone Morphogenetic Protein 2 In 3d Printed Pcl/Βtcp Scaffolds, Sara M. Kasten

Dental Theses

Recombinant human bone morphogenetic protein-2 (rhBMP-2) is a clinically available osteoinductive growth factor. In its current form, approved for clinical use, however, the growth factor is delivered in excessively high doses, resulting in unpredictable bone growth and unwanted, sometimes life-threatening, clinical side effects. It has clearly been demonstrated that the sustained, long-term release of the proteins can lead to improved ossification, owing particularly to the rapid metabolism of the biologically active growth factor when delivered alone in solution. Delivery systems for rhBMP-2 have been investigated extensively; yet still, further exploration into the best means of protein delivery — in order to ...


Chhs June 2016 Icymi, Dr. John Bonaguro, VaShon S. Wells, editor, College of Health and Human Services 2016 Western Kentucky University

Chhs June 2016 Icymi, Dr. John Bonaguro, Vashon S. Wells, Editor, College Of Health And Human Services

College of Health & Human Services Publications

No abstract provided.


Changes In Dentist Retirement, Relocation, And Net Inflow Of Dentist Supply In Iowa, 1997-2014: Fifth Brief In A Series, Julie C. Reynolds, Susan C. McKernan, Raymond A. Kuthy, Nyla Balakrishnan 2016 University of Iowa

Changes In Dentist Retirement, Relocation, And Net Inflow Of Dentist Supply In Iowa, 1997-2014: Fifth Brief In A Series, Julie C. Reynolds, Susan C. Mckernan, Raymond A. Kuthy, Nyla Balakrishnan

Health Policy

The number of dentists in Iowa has gradually increased over the past two decades. However, this increase has not kept pace with the national rate. As an increasing proportion of Iowa dentists approach retirement age, the supply and geographical distribution of Iowa’s dentist workforce may be adversely affected in coming years. This brief examines the flow of dentists in and out of Iowa’s dental workforce from 1997 to 2014, an 18-year period. This report focuses on voluntary retirement and relocation out of Iowa, since these are the primary means by which dentists leave the state’s workforce.


The Expert Advice: Dental Patient Compliance Hinges On Effective Communication Strategies, Diana V. Macri 2016 CUNY Hostos Community College

The Expert Advice: Dental Patient Compliance Hinges On Effective Communication Strategies, Diana V. Macri

Publications and Research

Most dental hygienists would agree that motivating patients to adopt good oral health behaviors-often referred to as compliance-is the most challenging aspect of practice. This critical component of patient care is not unique to dentistry and dental hygiene. In 2010, the costs of health care in the United States exceeded $2.7 trillion with "between $100 and $300 billion of avoidable health-care costs [attributable] to nonadherence in the US annually."1 Nonadherence (a term used in the medical literature, which is synonymous with noncompliance) is associated with progression of disease and, subsequently, poor health outcomes resulting in an additional burden ...


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