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Microfluidic Plga Microcapsules For The Sustained Delivery Of Recombinant Human Bone Morphogenetic Protein 2 In 3d Printed Pcl/Βtcp Scaffolds, Sara M. Kasten 2016 University of Pennsylvania School of Dental Medicine

Microfluidic Plga Microcapsules For The Sustained Delivery Of Recombinant Human Bone Morphogenetic Protein 2 In 3d Printed Pcl/Βtcp Scaffolds, Sara M. Kasten

Dental Theses

Recombinant human bone morphogenetic protein-2 (rhBMP-2) is a clinically available osteoinductive growth factor. In its current form, approved for clinical use, however, the growth factor is delivered in excessively high doses, resulting in unpredictable bone growth and unwanted, sometimes life-threatening, clinical side effects. It has clearly been demonstrated that the sustained, long-term release of the proteins can lead to improved ossification, owing particularly to the rapid metabolism of the biologically active growth factor when delivered alone in solution. Delivery systems for rhBMP-2 have been investigated extensively; yet still, further exploration into the best means of protein delivery — in order to ...


Chhs June 2016 Icymi, Dr. John Bonaguro, VaShon S. Wells, editor, College of Health and Human Services 2016 Western Kentucky University

Chhs June 2016 Icymi, Dr. John Bonaguro, Vashon S. Wells, Editor, College Of Health And Human Services

College of Health & Human Services Publications

No abstract provided.


The Expert Advice: Dental Patient Compliance Hinges On Effective Communication Strategies, Diana V. Macri 2016 CUNY Hostos Community College

The Expert Advice: Dental Patient Compliance Hinges On Effective Communication Strategies, Diana V. Macri

Publications and Research

Most dental hygienists would agree that motivating patients to adopt good oral health behaviors-often referred to as compliance-is the most challenging aspect of practice. This critical component of patient care is not unique to dentistry and dental hygiene. In 2010, the costs of health care in the United States exceeded $2.7 trillion with "between $100 and $300 billion of avoidable health-care costs [attributable] to nonadherence in the US annually."1 Nonadherence (a term used in the medical literature, which is synonymous with noncompliance) is associated with progression of disease and, subsequently, poor health outcomes resulting in an additional burden ...


Investigation On The Physical Properties Of Denture Base Resin Filled With Nano-Barium Titanate.Pdf, Nidal Elshereksi 2016 Universiti Kebangsaan Malaysia

Investigation On The Physical Properties Of Denture Base Resin Filled With Nano-Barium Titanate.Pdf, Nidal Elshereksi

Nidal Elshereksi

Background: Poly(methyl methacrylate) (PMMA) is the material of choice for denture
base construction because of its many good qualities. However, PMMA suffers from
polymerization shrinkage and low strength, and its slow water absorption causes serious
warpage and dimensional change in the material. Objective: This study aimed to
evaluate the effect of nano-barium titanate (NBT) inclusion on the water absorption,
polymerization shrinkage, and surface hardness of PMMA denture base. Results: The
PMMA composites showed lower water absorption and polymerization shrinkage than
pure PMMA. The density of the PMMA composites was increased by 5%, and a
marked improvement in surface hardness ...


Review Of Approaches To Caries Treatment, Cherissa Chong 2016 University of Pennsylvania

Review Of Approaches To Caries Treatment, Cherissa Chong

Dental Theses

Dental caries is considered to be one of the most prevalent infectious disease in humans across all age groups because they affect 60-90% of the world’s population. With the introduction of refined sugar into the modern diet and an improved understanding of the pathogenesis of dental caries, the need for novel approaches to caries prevention has become is a key undertaking for addressing the caries burden in the 21st century. While previous studies have shown successful elimination of bacteria in the oral cavity, only a few modalities such as antimicrobial peptides, vaccines and more recently, nanoparticles, have been developed ...


Effect Rankl Produced By Periodontal Ligament Cells On Orthodontic Tooth Movement, Chia-Ying Yang 2016 University of Pennsylvania

Effect Rankl Produced By Periodontal Ligament Cells On Orthodontic Tooth Movement, Chia-Ying Yang

Dental Theses

The bone remodeling process involved in orthodontic tooth movement consists of bone resorption on the compression side and bone formation on the tension side of the teeth. Osteoclasts play an important role in bone remodeling and are necessary for orthodontic tooth movement. Receptor activator of nuclear factor-κB ligand (RANKL) is essential for osteoclast formation and differentiation. Several cell types have been reported to be capable of producing RANKL. We are interested in whether there is a dominant cell type which RANKL production is critical in generating orthodontic tooth movement. In this study, we used a Cre recombinase mouse model to ...


Contribution Of Probiotics Streptococcus Salivarius Strains K12 And M18 To Oral Health In Humans: A Review, Turner A. Stowik 2016 University of Connecticut

Contribution Of Probiotics Streptococcus Salivarius Strains K12 And M18 To Oral Health In Humans: A Review, Turner A. Stowik

Honors Scholar Theses

The overgrowth and disequilibrium of pathogenic microorganism species both native and non-native to the oral cavity can manifest into a variety of different oral diseases, pathologies, and afflictions in humans, including dental caries, gingivitis, pharyngitis, halitosis, and oral candidiasis. Two bacterial strains with clinically-significant probiotic applications in curtailing the pathogenic bacterial growth involved in these conditions are Streptococcus salivarius strain K12 and Streptococcus salivarius strain M18. To summarize the most up-to-date in vitro, in vivo, and clinical research findings, administration of these S. salivarius strains typically in the form of probiotic lozenges results in colonization, reduction in inflammatory measures, and ...


Influence Of In-Office Oral Hygiene Instructions On The Parental Assessment Of Their Child's Oral Health., Sireesha Kodali 2016 University of Louisville

Influence Of In-Office Oral Hygiene Instructions On The Parental Assessment Of Their Child's Oral Health., Sireesha Kodali

Electronic Theses and Dissertations

Purpose: To identify the relation between oral health education and parental assessment of their child’s dental condition. Methods: Our study population included 33,342 children, from Smile KY! annual screenings from 2002 to 20014. Data collection was through questionnaire forms. Our primary risk factor was “dental health instructions received” (yes/no) and our outcome of interest was “parental assessment of your child’s dental health” (good/fair/poor). We had 13 years of data from 2002 to 2014 and used ‘SAS’ statistical software for data manipulation and recoding. Descriptive statistics, chi-square test of independence, trend analysis and multiple logistic ...


Porphyromonas Gingivalis Gingipains Induce A Pro-Inflammatory Extracellular Microenvironment : The Role Of Par-2 And Fibronectin., Jeffrey S. Marschall 2016 University of Louisville

Porphyromonas Gingivalis Gingipains Induce A Pro-Inflammatory Extracellular Microenvironment : The Role Of Par-2 And Fibronectin., Jeffrey S. Marschall

Electronic Theses and Dissertations

Periodontitis is a chronic inflammatory disease that is characterized by severe tissue destruction of the gingiva and other tooth supporting structures; if left untreated, tooth loss and disintegration of the alveolar bone occurs. This chronic inflammatory state has been linked to other systemic diseases such as cardiovascular disease, diabetes, rheumatoid arthritis, and Alzheimer’s disease. Porphyromonas gingivalis is the major pathogenic microbe in periodontitis. The main virulence factors of P. gingivalis are the Arg-aa and Lys-aa gingipains, which are proteolytic enzymes implicated in a plethora of activities that allow P. gingivalis to subvert the human immune system in the oral ...


Objective Evaluation Of Clinical Shade-Matching Outcomes., Erin Ballard 2016 University of Louisville

Objective Evaluation Of Clinical Shade-Matching Outcomes., Erin Ballard

Electronic Theses and Dissertations

The purpose of this study was to objectively evaluate shade-matching outcomes within an academic institution. Using the Spectrophotometer, E was calculated between the reference shade: restoration shade () and restoration shade: prescription shade (). The t-test was used to determine if E maintained clinical acceptance at E: 3.7. Satisfaction with shade-match and need for objective measurement were surveyed using a Five Point Likert Scale. Correlational relationships were assessed via Pearson Correlation. Mean E values were above the acceptance value (pppp


Modification Of T9ss Cargo Proteins Of Porphyromonas Gingivalis For Their Secretion In Soluble Form And Purification By Affinity Chromatography., Apoorv Goel 2016 University of Louisville

Modification Of T9ss Cargo Proteins Of Porphyromonas Gingivalis For Their Secretion In Soluble Form And Purification By Affinity Chromatography., Apoorv Goel

Electronic Theses and Dissertations

Background: Porphyromonas gingivalis, a keystone-pathogen associated with periodontitis, utilizes the Type IX Secretion System (T9SS) to secrete proteins bearing the conserved C-terminal domain (CTD), many of which are essential virulence factors. These include, besides gingipains and PPAD, 29 other proteins. During or after the outer membrane translocation the CTD is cleaved off and a glycan moiety is covalently attached anchoring the secreted proteins at the bacterial cell surface. Objective: Most of the CTD bearing proteins have only hypothetical functions assigned. It is plausible that these CTD bearing proteins may also play a crucial role in P. gingivalis pathogenesis. Therefore, it ...


Long Term Facial Alveolar Bone Changes Associated With Endosseous Implants In The Anterior Maxilla., Deepika Joshi 2016 University of Louisville

Long Term Facial Alveolar Bone Changes Associated With Endosseous Implants In The Anterior Maxilla., Deepika Joshi

Electronic Theses and Dissertations

Aim: To quantify the radiographic presence and thickness of facial alveolar bone (FABr) adjacent to implants placed in the anterior maxillary region. Lack of FABr may suggest that graft procedures are desirable prior to implant placement. Material and Methods: With IRB approval, a retrospective analysis of cone beam computed tomographic cross-sectional images of sites with at least one implant in the anterior maxillary region was performed. Details regarding type of implant and location were recorded. FABr perpendicular to the long axis each implant was measured at seven levels by two observers independently and means and standard deviations ...


Tobacco-Gene Activity Profile In Porphyromonas Gingivalis, Filifactor Alocis And Treponema Denticola., Neelima Chowdary Cherukumalli 2016 University of Louisville

Tobacco-Gene Activity Profile In Porphyromonas Gingivalis, Filifactor Alocis And Treponema Denticola., Neelima Chowdary Cherukumalli

Electronic Theses and Dissertations

Smoking is an established risk factor for periodontitis. Prior studies have shown that cigarette smoke extract (CSE) can induce profound phenotypic changes in Porphyromonas gingivalis and alters the virulence of this important periodontal pathogen. We hypothesized that CSE might also alter gene expression in established periodontal pathogens, Porphyromonas gingivalis and Treponema denticola, as well as in the emerging pathogen, Filifactor alocis. Oral bacteria were grown in CSE-conditioned medium (1000 ng/ml nicotine equivalents) or in unconditioned control medium. Total RNA was extracted and CSE-regulated genes were identified by comparison of the mRNA profiles of CSE with control cultures using RNA-Seq ...


Chhs May 2016 Icymi, Dr. John Bonaguro, Dean, VaShon S. Wells, editor, College of Health and Human Services 2016 College of Health & Human Services, WKU

Chhs May 2016 Icymi, Dr. John Bonaguro, Dean, Vashon S. Wells, Editor, College Of Health And Human Services

College of Health & Human Services Publications

No abstract provided.


Healthy Teeth = Great Smiles, Jamie M. Hire, Autumn L. Graf, Kristen K. Liechty, Erika L. Purkiser 2016 Indiana University - Purdue University Fort Wayne

Healthy Teeth = Great Smiles, Jamie M. Hire, Autumn L. Graf, Kristen K. Liechty, Erika L. Purkiser

2002 IPFW Student Research and Creative Endeavor Symposium

No abstract provided.


Barr, Edward Wallace, 1887-1962 (Mss 576), Manuscripts & Folklife Archives 2016 Western Kentucky University

Barr, Edward Wallace, 1887-1962 (Mss 576), Manuscripts & Folklife Archives

MSS Finding Aids

Finding aid only for Manuscripts Collection 576. Papers, lecture notes and appointment book relating to Dr. E. Wallace Barr’s training and service as a dentist with the American Expeditionary Forces during World War I; includes a few items of family correspondence.


Root Caries: A Hands-On Workshop, Linda C. Niessen, Gretchen Gibson 2016 Nova Southeastern University

Root Caries: A Hands-On Workshop, Linda C. Niessen, Gretchen Gibson

Linda Niessen

No abstract provided.


Oral And Pharyngeal Cancer Trends In Va Hospital Discharges, Linda C. Niessen, D. J. Fedele, J. A. Jones 2016 Nova Southeastern University

Oral And Pharyngeal Cancer Trends In Va Hospital Discharges, Linda C. Niessen, D. J. Fedele, J. A. Jones

Linda Niessen

No abstract provided.


Oral Health For Older Women, Linda C. Niessen 2016 Nova Southeastern University

Oral Health For Older Women, Linda C. Niessen

Linda Niessen

No abstract provided.


Oral Health And Social Justice: Opportunities For Leadership, Linda C. Niessen 2016 Nova Southeastern University

Oral Health And Social Justice: Opportunities For Leadership, Linda C. Niessen

Linda Niessen

No abstract provided.


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