Open Access. Powered by Scholars. Published by Universities.®

Veterinary Medicine Commons

Open Access. Powered by Scholars. Published by Universities.®

5,700 Full-Text Articles 7,655 Authors 179,752 Downloads 42 Institutions

All Articles in Veterinary Medicine

Faceted Search

5,700 full-text articles. Page 1 of 37.

Plasma Concentrations Of Fenbendazole (Fbz) And Oxfendazole In Alpacas (Lama Pacos) After Single Intravenous And Oral Dosing Of Fbz, Jeffrey Lakritz, Daniel Linden, David E. Anderson, Terri A. Specht 2015 University of Tennessee - Knoxville

Plasma Concentrations Of Fenbendazole (Fbz) And Oxfendazole In Alpacas (Lama Pacos) After Single Intravenous And Oral Dosing Of Fbz, Jeffrey Lakritz, Daniel Linden, David E. Anderson, Terri A. Specht

David Edgar Anderson, DVM, MS, DACVS

The objective of this study was to determine plasma pharmacokinetics and bioavailability of fenbendazole (FBZ) and oxfendazole (OFZ) after intravenous (iv) and oral administrations of FBZ (5 mg/kg) to alpacas. Plasma concentrations of FBZ and OFZ after administration of FBZ iv and orally (5 mg/kg) were determined by high-performance liquid chromatography with ultraviolet detection. Total clearance (CL) of FBZ was 16.5±4 mL/kg/min (range: 4–31 mL/kg/min), and steady-state volume of distribution (Vdss) was 3.3±1 L/kg (range: 1.7–7.4 L/kg). The terminal phase half-life of FBZ after ...


Ectoparasitism Shortens The Breeding Season In A Colonial Bird, Charles R. Brown, Mary Bomberger Brown 2015 Department of Biological Sciences, University of Tulsa

Ectoparasitism Shortens The Breeding Season In A Colonial Bird, Charles R. Brown, Mary Bomberger Brown

Papers in Natural Resources

When blood-feeding parasites increase seasonally, their deleterious effects may prevent some host species, especially those living in large groups where parasites are numerous, from reproducing later in the summer. Yet the role of parasites in regulating the length of a host’s breeding season—and thus the host’s opportunity for multiple brooding—has not been systematically investigated. The highly colonial cliff swallow (Petrochelidon pyrrhonota), a temperate-latitude migratory songbird in the western Great Plains, USA, typically has a relatively short (eight to nine week) breeding season, with birds rarely nesting late in the summer. Colonies at which ectoparasitic swallow bugs ...


Repeated Stressors In Adulthood Increase The Rate Of Biological Ageing, James S. Adelman, Michaela Hau, Mark F. Haussmann, Timothy J. Greives, Christa Matlack, David Costantini, Michael Quetting, Ana C. Miranda, Jesko Partecke 2015 Virginia Polytechnic Institute and State University

Repeated Stressors In Adulthood Increase The Rate Of Biological Ageing, James S. Adelman, Michaela Hau, Mark F. Haussmann, Timothy J. Greives, Christa Matlack, David Costantini, Michael Quetting, Ana C. Miranda, Jesko Partecke

James S. Adelman

Individuals of the same age can differ substantially in the degree to which they have accumulated tissue damage, akin to bodily wear and tear, from past experiences. This accumulated tissue damage reflects the individual’s biological age and may better predict physiological and behavioural performance than the individual‘s chronological age. However, at present it remains unclear how to reliably assess biological age in individual wild vertebrates. We exposed hand-raised adult Eurasian blackbirds (Turdus merula) to a combination of repeated immune and disturbance stressors for over one year to determine the effects of chronic stress on potential biomarkers of biological ...


Genetic Parameter Estimates And Breed Effects For Calving Difficulty And Birth Weight In A Multi-Breed Population, Cashley Ahlberg 2014 University of Nebraska-Lincoln

Genetic Parameter Estimates And Breed Effects For Calving Difficulty And Birth Weight In A Multi-Breed Population, Cashley Ahlberg

Theses and Dissertations in Animal Science

There are multiple breeds of beef cattle available to utilize in breeding systems to maximize production and economics. Calving difficulty (dystocia) is a significant cost to beef production and is more prevalent in first-calf heifers. The objectives of this study were to estimate genetic parameters and breed differences for calving difficulty and birth weight as a first step towards the development of across-breed adjustment factors for calving difficulty.

Two models were employed to analyze birth weight (BWT) and calving difficulty (CD) recorded on 4,579 first parity females from the Germplasm Evaluation program at the U.S. Meat Animal Research ...


Evaluation Of The Effect Of Orally Administered Acid Suppressants On Intragastric Ph In Cats, S Parkinson, M Katherine Tolbert, K Messenger, A. Odunayo, M. Brand, G. Davidson, E. Peters, A. Reed, M. G. Papich 2014 University of Tennessee, Knoxville

Evaluation Of The Effect Of Orally Administered Acid Suppressants On Intragastric Ph In Cats, S Parkinson, M Katherine Tolbert, K Messenger, A. Odunayo, M. Brand, G. Davidson, E. Peters, A. Reed, M. G. Papich

M Katherine Tolbert DVM, PhD, DACVIM

Background Acid suppressant drugs are a mainstay of treatment for cats with gastrointestinal erosion and ulceration. However, clinical studies have not been performed to compare the efficacy of commonly PO administered acid suppressants in cats.

Hypothesis/Objectives To compare the effect of PO administered famotidine, fractionated omeprazole tablet (fOT), and omeprazole reformulated paste (ORP) on intragastric pH in cats. We hypothesized that both omeprazole formulations would be superior to famotidine and placebo.

Animals Six healthy adult DSH colony cats.

Methods Utilizing a randomized, 4-way crossover design, cats received 0.88–1.26 mg/kg PO q12h fOT, ORP, famotidine, and ...


Effect Of A Core Conditioning Program On Lumbar Paraspinal Area, Asymmetry And Pain Score In Military Working Dogs With Lumbosacral Pain, Andrea Leigh Henderson 2014 University of Tennessee - Knoxville

Effect Of A Core Conditioning Program On Lumbar Paraspinal Area, Asymmetry And Pain Score In Military Working Dogs With Lumbosacral Pain, Andrea Leigh Henderson

Masters Theses

Introduction: Lumbosacral pain and stenosis are common causes of retirement from duty for Military Working Dogs (MWDs). Working dogs that receive surgical management for this condition often have a poor prognosis for return to duty after recovery. Humans with chronic low back pain demonstrate paraspinal muscle asymmetry, pain and dysfunction that often improve in response to an exercise program. This study investigated whether dogs with mild lumbosacral pain have decreased lumbar paraspinal muscle area, symmetry, and density, as well as increased pain and dysfunction compared to control dogs. Additionally, response of pain and dysfunction to an exercise program was assessed ...


Differentiation Of Equine Mesenchymal Stromal Cells Into Cells Of Neural Lineage And Their Application Into A Novel Model For Acute Peripheral Nerve Injury In The Horse, Claudia Cruz 2014 University of Tennessee - Knoxville

Differentiation Of Equine Mesenchymal Stromal Cells Into Cells Of Neural Lineage And Their Application Into A Novel Model For Acute Peripheral Nerve Injury In The Horse, Claudia Cruz

Masters Theses

Studies have shown that mesenchymal stromal cells (MSCs) are able to differentiate into extra-mesodermal lineages, including neurons. Positive outcomes were obtained after transplantation of neurally-induced MSCs in rats, rabbits and guinea pigs after nerve injury, but the effect of these cells is unknown in horses. Our objective was to test the ability of equine mesenchymal stromal cells to differentiate into cells of neuronal lineage, and to assess differences, if any, in morphology and protein expression. Additionally, we wanted to investigate if horse age and cell passage number contributed to the ability to achieve neural differentiation.

The first part of this ...


Effect Of Small Interfering Rnas On In Vitro Replication And Gene Expression Of Feline Coronavirus, Eman Ahmed Mohamed Anis 2014 University of Tennessee - Knoxville

Effect Of Small Interfering Rnas On In Vitro Replication And Gene Expression Of Feline Coronavirus, Eman Ahmed Mohamed Anis

Doctoral Dissertations

Feline corononavirus (FCoV) infection is ubiquitous in domestic cat populations worldwide and is usually associated with subclinical or mild enteritis. However, in some cats infection may result in the development of a fatal progressive disease called feline infectious peritonitis (FIP). FIP is considered to be the major cause of infectious-related death in pet cats. Currently, there is no protective vaccine or curative treatment to this highly fatal disease. In this study, we evaluated the ability of small interfering RNAs (siRNAs) to inhibit the in vitro viral replication and gene expression of FCoV as a potential treatment for FIP.

Five synthetic ...


Glutaredoxin 2 (Grx2) Gene Deletion Induces Early Onset Of Age-Dependent Cataracts In Mice, Hongli Wu, Yibo Yu, Larry David, Ye-Shih Ho, Marjorie F. Lou 2014 University of North Texas Health Science Center

Glutaredoxin 2 (Grx2) Gene Deletion Induces Early Onset Of Age-Dependent Cataracts In Mice, Hongli Wu, Yibo Yu, Larry David, Ye-Shih Ho, Marjorie F. Lou

Papers in Veterinary and Biomedical Science

Glutaredoxin 2 (Grx2) is an isozyme of glutaredoxin1 (thioltransferase) present in the mitochondria and nucleus with disulfide reductase and peroxidase activities, and it controls thiol/ disulfide balance in cells. In this study, we investigated whether Grx2 gene deletion could induce faster age-related cataract formation and elucidated the biochemical changes effected by Grx2 gene deletion that may contribute to lens opacity. Slit lamp was used to examine the lenses in Grx2 knock-out (KO) mice and age-matched wild-type (WT) mice ages 1 to 16 months. In the Grx2 null mice, the lens nuclear opacity began at 5 months, 3 months sooner than ...


Glucose Significantly Enhances Enterotoxigenic Escherichia Coli Adherence To Intestinal Epithelial Cells Through Its Effects On Heat-Labile Enterotoxin Production, Prageeth Wijemanne, Rodney A. Moxley 2014 University of Nebraska-Lincoln

Glucose Significantly Enhances Enterotoxigenic Escherichia Coli Adherence To Intestinal Epithelial Cells Through Its Effects On Heat-Labile Enterotoxin Production, Prageeth Wijemanne, Rodney A. Moxley

Papers in Veterinary and Biomedical Science

The present study tested whether exposure of enterotoxigenic Escherichia coli (ETEC) to glucose at different concentrations in the media results in increased bacterial adherence to host cells through increased heat-labile enterotoxin (LT) production, thereby suggesting the effects are physiological. Porcine-origin ETEC strains grown in Casamino acid yeast extract medium containing different concentrations of glucose were washed and inoculated onto IPEC-J2 porcine intestinal epithelial cells to test for effects on adherence and host cell cAMP concentrations. Consistent with previous studies, all LT+ strains had higher ETEC adherence to IPEC-J2 cells than did LT2 strains. Adherence of the LT2 but not the ...


Animal Models And Therapeutic Molecular Targets Of Cancer: Utility And Limitations., Maria Cekanova MS, RNDr, PhD, Kusum Rathore 2014 University of Tennessee - Knoxville

Animal Models And Therapeutic Molecular Targets Of Cancer: Utility And Limitations., Maria Cekanova Ms, Rndr, Phd, Kusum Rathore

Maria Cekanova MS, RNDr, PhD

Cancer is the term used to describe over 100 diseases that share several common hallmarks. Despite prevention, early detection, and novel therapies, cancer is still the second leading cause of death in the USA. Successful bench-to-bedside translation of basic scientific findings about cancer into therapeutic interventions for patients depends on the selection of appropriate animal experimental models. Cancer research uses animal and human cancer cell lines in vitro to study biochemical pathways in these cancer cells. In this review, we summarize the important animal models of cancer with focus on their advantages and limitations. Mouse cancer models are well known ...


C.A.R.E.S. (Canine Arthritis, Rehabilitation, Exercise, And Sports Medicine) Newsletter, Darryl L. Millis 2014 University of Tennessee, Knoxville

C.A.R.E.S. (Canine Arthritis, Rehabilitation, Exercise, And Sports Medicine) Newsletter, Darryl L. Millis

Darryl L. Millis

No abstract provided.


Gentle Doctor (Vol. 28, No. 2), Iowa State University College of Veterinary Medicine 2014 Iowa State University

Gentle Doctor (Vol. 28, No. 2), Iowa State University College Of Veterinary Medicine

Gentle Doctor

Contents: Lions and Tigers and Bears and Sea Cucumbers; Band of Brothers; Topher the Wonder Dog; A Life Entwined with Iowa State; The Bench; Honoring Dr. Darrell Trampel


Development Of A Fatal Noncompressible Truncal Hemorrhage Model With Combined Hepatic And Portal Venous Injury In Normothermic Normovolemic Swine, Ujwal R. Yanala, Jason M. Johanning, Iraklis I. Pipinos, Gustavo Larsen, William H. Velander, Mark A. Carlson 2014 University of Nebraska Medical Center, Omaha

Development Of A Fatal Noncompressible Truncal Hemorrhage Model With Combined Hepatic And Portal Venous Injury In Normothermic Normovolemic Swine, Ujwal R. Yanala, Jason M. Johanning, Iraklis I. Pipinos, Gustavo Larsen, William H. Velander, Mark A. Carlson

William H. Velander Publications

Noncompressible truncal hemorrhage and brain injury currently account for most early mortality of warfighters on the battlefield. There is no effective treatment for noncompressible truncal hemorrhage, other than rapid evacuation to a surgical facility. The availability of an effective field treatment for noncompressible truncal hemorrhage could increase the number of warfighters salvaged from this frequently-lethal scenario. Our intent was to develop a porcine model of noncompressible truncal hemorrhage with a ,50% one-hour mortality so that we could develop new treatments for this difficult problem. Normovolemic normothermic domestic swine (barrows, 3 months old, 34–36 kg) underwent one of three injury ...


Annotated Bibliography: Attitudes Toward Animal Research (1998-2013), Erich Yahner 2014 Humane Society Institute for Science and Policy

Annotated Bibliography: Attitudes Toward Animal Research (1998-2013), Erich Yahner

Humane Education Bibliographies

No abstract provided.


Evaluation Of Pre-Harvest Screening For Antibiotics And Flunixin Meglumine In Cattle, Shuna A. Jones 2014 University of Nebraska-Lincoln

Evaluation Of Pre-Harvest Screening For Antibiotics And Flunixin Meglumine In Cattle, Shuna A. Jones

Dissertations & Theses in Veterinary and Biomedical Science

Many antibiotics and medications used in the treatment of animals have a withdrawal time; residues are a concern for the meat industry. The most recently published 2009 USDA-FSIS Residue Program Data Report listed 135,389 Inspector-In-Charge-Generated (IICG) residue samples from 43,142,500 beef and dairy cattle inspected that year at harvest (USDA-FSIS 2009a). Of these samples, 1306 contained violative antibiotic residues and 327 violative flunixin meglumine residues. Two classes of antimicrobials comprised over half of the documented violative antimicrobial residues (beta-lactams that include ceftiofur and sulfa drugs that include sulfadimethoxine). While the violative residue rate seems small, violative residues ...


The Mucosal Expression Pattern Of Interferon-Ε In Rhesus Macaques, Andrew Demers, Guobin Kang, Fangrui Ma, Wuxun Lu, Zhe Yuan, Yue Li, Mark Lewis, Edmundo N. Kraiselburd, Luis Montaner, Qingsheng Li 2014 University of Nebraska-Lincoln

The Mucosal Expression Pattern Of Interferon-Ε In Rhesus Macaques, Andrew Demers, Guobin Kang, Fangrui Ma, Wuxun Lu, Zhe Yuan, Yue Li, Mark Lewis, Edmundo N. Kraiselburd, Luis Montaner, Qingsheng Li

Qingsheng Li Publications

Type I IFNs play an important role in innate and adaptive immunity against viral infections. A novel type I IFN, namely IFN-ε, which can protect against vaginal transmission of HSV2 and Chlamydia muridarum bacterial infection, has been described in mice and humans. Nevertheless, the principle cell type and the expression pattern of IFN-ε in tissues remain uncertain. In addition, the expression of IFN-ε in Indian rhesus macaques (Macaca mulatta) has not been reported. Here, we analyzed IFN-ε expression in multiple mucosal sites of uninfected or SIV-infected Indian rhesus macaques using IHCS. We report for the first time the detection of ...


Small Animal Bandaging, Erin Wood 2014 University of Tennessee, Knoxville

Small Animal Bandaging, Erin Wood

Veterinary Partners Appreciation Conference (V-PAC)

No abstract provided.


Rabies Vaccination Protocols And Pitfalls, Zenny Ng 2014 University of Tennessee, Knoxville

Rabies Vaccination Protocols And Pitfalls, Zenny Ng

Veterinary Partners Appreciation Conference (V-PAC)

No abstract provided.


Chloramphenicol In Horses, Eva McElligot 2014 University of Tennessee, Knoxville

Chloramphenicol In Horses, Eva Mcelligot

Veterinary Partners Appreciation Conference (V-PAC)

No abstract provided.


Digital Commons powered by bepress