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Research Data Practices In Veterinary Medicine: A Case Study, Erin E. Kerby 2015 University of Illinois at Urbana-Champaign

Research Data Practices In Veterinary Medicine: A Case Study, Erin E. Kerby

Journal of eScience Librarianship

Objective: To determine trends in research data output, reuse, and sharing of the college of veterinary medicine faculty members at a large academic research institution.

Methods: This bibliographic study was conducted by examining original research articles for indication of the types of data produced, as well as evidence that the authors reused data or made provision for sharing their own data. Findings were recorded in the categories of research type, data type, data reuse, data sharing, author collaboration, and grants/funding and were analyzed to determine trends.

Results: A variety of different data types were encountered in this study, even ...


Repurposing Celecoxib As A Topical Antimicrobial Agent, Shankar Thangamani, Waleed Younis, Mohamed N. Seleem 2015 Purdue University

Repurposing Celecoxib As A Topical Antimicrobial Agent, Shankar Thangamani, Waleed Younis, Mohamed N. Seleem

Department of Comparative Pathobiology Faculty Publications

There is an urgent need for new antibiotics and alternative strategies to combat multidrug-resistant bacterial pathogens, which are a growing clinical issue. Repurposing existing approved drugs with known pharmacology and toxicology is an alternative strategy to accelerate antimicrobial research and development. In this study, we show that celecoxib, a marketed inhibitor of cyclooxygenase-2, exhibits broad-spectrum antimicrobial activity against Gram-positive pathogens from a variety of genera, including Staphylococcus, Streptococcus, Listeria, Bacillus, and Mycobacterium, but not against Gram-negative pathogens. However, celecoxib is active against all of the Gram-negative bacteria tested, including strains of, Acinetobacter, and Pseudomonas, when their intrinsic resistance is artificially ...


In Vitro And In Vivo Evaluation Of Infestation Deterrents Against Lice, Kyong-Sup Yoon, Jennifer K. Ketzis, Samuel W. Andrewes, Christopher S. Wu, Kris Honraet, Dorien Staljanssens, Bart Rossel, J Marshall Clark 2015 Southern Illinois University Edwardsville

In Vitro And In Vivo Evaluation Of Infestation Deterrents Against Lice, Kyong-Sup Yoon, Jennifer K. Ketzis, Samuel W. Andrewes, Christopher S. Wu, Kris Honraet, Dorien Staljanssens, Bart Rossel, J Marshall Clark

SIUE Faculty Research, Scholarship, and Creative Activity

The human head louse is a cosmopolitan ectoparasite and frequently infests many people, particularly school-age children. Due to widespread pyrethroid resistance and the lack of efficient resistance management, there has been a considerable interest in the protection of uninfested people and prevention of reinfestation by disrupting lice transfer. In this study, two nonclinical model systems (in vitro and in vivo) were used to determine the efficacy of the infestation deterrents, Elimax lotion and Elimax shampoo, against human head lice or poultry chewing lice, respectively. With in vitro assessments, female head lice exhibited significantly higher avoidance responses to hair tufts treated ...


Fecal Volatile Organic Ccompound Profiles From White-Tailed Deer (Odocoileus Virginianus) As Indicators Of Mycobacterium Bovis Exposure Or Mycobacterium Bovis Bacille Calmette-Guerin (Bcg) Vaccination, Randal S. Stahl, Christine K. Ellis, Pauline Nol, W. Ray Waters, Kurt C. VerCauteren 2015 U.S. Department of Agriculture

Fecal Volatile Organic Ccompound Profiles From White-Tailed Deer (Odocoileus Virginianus) As Indicators Of Mycobacterium Bovis Exposure Or Mycobacterium Bovis Bacille Calmette-Guerin (Bcg) Vaccination, Randal S. Stahl, Christine K. Ellis, Pauline Nol, W. Ray Waters, Kurt C. Vercauteren

USDA National Wildlife Research Center - Staff Publications

White-tailed deer (Odocoileus virginianus) serve as a reservoir for bovine tuberculosis, caused by Mycobacterium bovis, and can be a source of infection in cattle. Vaccination with M. bovis Bacille Calmette Guerin (BCG) is being considered for management of bovine tuberculosis in deer. Presently, no method exists to non-invasively monitor the presence of bovine tuberculosis in deer. In this study, volatile organic compound profiles of BCG-vaccinated and non-vaccinated deer, before and after experimental challenge with M. bovis strain 95–1315, were generated using solid phase microextraction fiber head-space sampling over suspended fecal pellets with analysis by gas chromatography/mass spectrometry. Chromatograms ...


Development Of An In Vivo Exsheathment Assay Of Infective L3 Haemonchus Contortus Larvae In Fistualated Sheep, Holly N. Williams, Katherine Petersson, Carly Barone 2015 University of Rhode Island

Development Of An In Vivo Exsheathment Assay Of Infective L3 Haemonchus Contortus Larvae In Fistualated Sheep, Holly N. Williams, Katherine Petersson, Carly Barone

Senior Honors Projects

Purpose: Gastrointestinal nematodes (GIN) hinder the sustainable production of small ruminants on pasture and parasite resistance to chemical dewormers is becoming a growing concern. Condensed tannin containing legume forages are being tested to evaluate their anti-parasitic properties and potential contribution to an overall parasite control program for small ruminants such as sheep and goats. One of the most pathogenic GIN of small ruminants is Haemonchus contortus. The final step to full infectivity of H. contortus third stage larvae (L3) is exsheathment in the rumen. The objective of this study was to establish an in-vivo exsheathment assay in fistulated sheep as ...


A Behavioral Analysis Of The Pre-Release Tasmanian Devils (Sarcophilus Harrisii) Currently At Devils@Cradle: An Assessment Of The Impacts Of Captivity On The Wild Behaviors Of Tasmanian Devils That Are Important For Their Reintroduction, Survival, And Inclusion In Wild Populations, Anna Staudenmaier 2015 SIT Study Abroad

A Behavioral Analysis Of The Pre-Release Tasmanian Devils (Sarcophilus Harrisii) Currently At Devils@Cradle: An Assessment Of The Impacts Of Captivity On The Wild Behaviors Of Tasmanian Devils That Are Important For Their Reintroduction, Survival, And Inclusion In Wild Populations, Anna Staudenmaier

Independent Study Project (ISP) Collection

The Tasmanian devil, Sarcophilus harrisi, is in danger of extinction in the wild due to the emergence of Devil Facial Tumor Disease (DFTD). In an attempt to save the species the Save the Tasmanian Devil Program (STTDP) has initiated the creation of an ‘Insurance Population’. These insurance animals are a part of the captive breeding population (CBP) designed to conserve the genetic diversity of the species to preserve their ecological function for their future reintroduction into the wild. CBPs are located at various bio-secure zoos, wildlife parks, free-range enclosures (FREs), Tasmanian islands and peninsulas and sanctuaries like Devils@Cradle - Tasmanian ...


Relationship Between Heat-Labile Enterotoxin Secretion Capacity And Virulence In Wild Type Porcine-Origin Enterotoxigenic Escherichia Coli Strains, Prageeth Wijemanne, Jun Xing, Emil M. Berberov, David B. Marx, David H. Francis, Rodney A. Moxley 2015 University of Nebraska-Lincoln

Relationship Between Heat-Labile Enterotoxin Secretion Capacity And Virulence In Wild Type Porcine-Origin Enterotoxigenic Escherichia Coli Strains, Prageeth Wijemanne, Jun Xing, Emil M. Berberov, David B. Marx, David H. Francis, Rodney A. Moxley

Papers in Veterinary and Biomedical Science

Heat-labile enterotoxin (LT) is an important virulence factor secreted by some strains of enterotoxigenic Escherichia coli (ETEC). The prototypic human-origin strain H10407 secretes LT via a type II secretion system(T2SS). We sought to determine the relationship between the capacity to secrete LT and virulence in porcine-origin wild type (WT) ETEC strains. Sixteen WT ETEC strains isolated from cases of severe diarrheal disease were analyzed by GM1ganglioside enzyme- linked immunosorbent assay tomeasure LT concentrations in culture supernatants. All strains had detectable LT in supernatants by 2 h of culture and 1 strain, which was particularly virulent in gnotobiotic piglets (3030-2 ...


Species-Specific And Pathotype-Specific Binding Of Bacteria To Zymogen Granule Membrane Glycoprotein 2 (Gp2), Peter Schierack, Stefan Rödiger, Rafal Kolenda, Rico Hiemann, Enrico Berger, Krzysztof Grzymajło, Alexander Swidsinski, Thomas Juretzek, Dirk Meissner, Karsten Mydlak, Dirk Reinhold, Lisa K. Nolan, Dirk Roggenbuck 2015 Brandenburgische Technische Universität Cottbus-Senftenberg

Species-Specific And Pathotype-Specific Binding Of Bacteria To Zymogen Granule Membrane Glycoprotein 2 (Gp2), Peter Schierack, Stefan Rödiger, Rafal Kolenda, Rico Hiemann, Enrico Berger, Krzysztof Grzymajło, Alexander Swidsinski, Thomas Juretzek, Dirk Meissner, Karsten Mydlak, Dirk Reinhold, Lisa K. Nolan, Dirk Roggenbuck

Veterinary Microbiology and Preventive Medicine Publications and Papers

With interest we read the paper by Juste et al 1 proposing the amount of zymogen-granule membrane glycoprotein 2 (GP2) on the surface of intestinal bacteria as a Crohn's disease (CD) marker. Indeed, a decreased GP2 level was found on microbes in patients with CD as compared to those of healthy controls. GP2 is a homologue to the urinary Tamm–Horsefall protein demonstrating an antimicrobial function by binding type 1-fimbriated uropathogenic Escherichia coli (UPEC). Likewise, GP2 seems to interact with intestinal bacteria as a specific receptor of bacterial type-1 fimbriae (FimH) on intestinal microfold cells that are partaking in ...


Plasma Concentrations Of Fenbendazole (Fbz) And Oxfendazole In Alpacas (Lama Pacos) After Single Intravenous And Oral Dosing Of Fbz, Jeffrey Lakritz, Daniel Linden, David E. Anderson, Terri A. Specht 2015 University of Tennessee - Knoxville

Plasma Concentrations Of Fenbendazole (Fbz) And Oxfendazole In Alpacas (Lama Pacos) After Single Intravenous And Oral Dosing Of Fbz, Jeffrey Lakritz, Daniel Linden, David E. Anderson, Terri A. Specht

David Edgar Anderson, DVM, MS, DACVS

The objective of this study was to determine plasma pharmacokinetics and bioavailability of fenbendazole (FBZ) and oxfendazole (OFZ) after intravenous (iv) and oral administrations of FBZ (5 mg/kg) to alpacas. Plasma concentrations of FBZ and OFZ after administration of FBZ iv and orally (5 mg/kg) were determined by high-performance liquid chromatography with ultraviolet detection. Total clearance (CL) of FBZ was 16.5±4 mL/kg/min (range: 4–31 mL/kg/min), and steady-state volume of distribution (Vdss) was 3.3±1 L/kg (range: 1.7–7.4 L/kg). The terminal phase half-life of FBZ after ...


Systems-Based Analysis Of The Sarcocystis Neurona Genome Identifies Pathways That Contribute To A Heteroxenous Life Cycle, Tomasz Blazejewski, Nirvana Nursimulu, Viviana Pszenny, Sriveny Dangoudoubiyam, Sivaranjani Namasivayam, Melissa A. Chiasson, Kyle Chessman, Michelle Tonkin, Lakshmipuram S. Swapna, Stacy S. Hung, Joshua Bridgers, Stacy M. Ricklefs, Martin J. Boulanger, Jitender P. Dubey, Stephen F. Porcella, Jessica C. Kissinger, Daniel K. Howe, Michael E. Grigg, John Parkinson 2015 Hospital for Sick Children, Canada

Systems-Based Analysis Of The Sarcocystis Neurona Genome Identifies Pathways That Contribute To A Heteroxenous Life Cycle, Tomasz Blazejewski, Nirvana Nursimulu, Viviana Pszenny, Sriveny Dangoudoubiyam, Sivaranjani Namasivayam, Melissa A. Chiasson, Kyle Chessman, Michelle Tonkin, Lakshmipuram S. Swapna, Stacy S. Hung, Joshua Bridgers, Stacy M. Ricklefs, Martin J. Boulanger, Jitender P. Dubey, Stephen F. Porcella, Jessica C. Kissinger, Daniel K. Howe, Michael E. Grigg, John Parkinson

Veterinary Science Faculty Publications

Sarcocystis neurona is a member of the coccidia, a clade of single-celled parasites of medical and veterinary importance including Eimeria, Sarcocystis, Neospora, and Toxoplasma. Unlike Eimeria, a single-host enteric pathogen, Sarcocystis, Neospora, and Toxoplasma are two-host parasites that infect and produce infectious tissue cysts in a wide range of intermediate hosts. As a genus, Sarcocystis is one of the most successful protozoan parasites; all vertebrates, including birds, reptiles, fish, and mammals are hosts to at least one Sarcocystis species. Here we sequenced Sarcocystis neurona, the causal agent of fatal equine protozoal myeloencephalitis. The S. neurona genome is 127 Mbp, more ...


Ectoparasitism Shortens The Breeding Season In A Colonial Bird, Charles R. Brown, Mary Bomberger Brown 2015 Department of Biological Sciences, University of Tulsa

Ectoparasitism Shortens The Breeding Season In A Colonial Bird, Charles R. Brown, Mary Bomberger Brown

Papers in Natural Resources

When blood-feeding parasites increase seasonally, their deleterious effects may prevent some host species, especially those living in large groups where parasites are numerous, from reproducing later in the summer. Yet the role of parasites in regulating the length of a host’s breeding season—and thus the host’s opportunity for multiple brooding—has not been systematically investigated. The highly colonial cliff swallow (Petrochelidon pyrrhonota), a temperate-latitude migratory songbird in the western Great Plains, USA, typically has a relatively short (eight to nine week) breeding season, with birds rarely nesting late in the summer. Colonies at which ectoparasitic swallow bugs ...


Crypto Prevention, Brian K. Whitlock 2015 University of Tennessee - Knoxville

Crypto Prevention, Brian K. Whitlock

Brian K Whitlock, PhD, DVM, DACT

No abstract provided.


Pregnancy Diagnosis In Cattle, Samantha L. Collins, Brian K. Whitlock 2015 University of Tennessee - Knoxville

Pregnancy Diagnosis In Cattle, Samantha L. Collins, Brian K. Whitlock

Brian K Whitlock, PhD, DVM, DACT

No abstract provided.


Efficacy Of Intravenous Administration Of Combined Acid Suppressants In Healthy Dogs, M Katherine Tolbert, Adesola Odunayo, R S. Howell, E E. Peters, Ann Reed 2015 University of Tennessee, Knoxville

Efficacy Of Intravenous Administration Of Combined Acid Suppressants In Healthy Dogs, M Katherine Tolbert, Adesola Odunayo, R S. Howell, E E. Peters, Ann Reed

M Katherine Tolbert DVM, PhD, DACVIM

Background Short-term intravenous co-administration of famotidine and pantoprazole is used by some veterinarians to treat gastrointestinal bleeding in critically ill dogs. However, clinical studies have not evaluated the efficacy of combination acid suppressant treatment in dogs.

Hypothesis/Objectives To compare the effect of intravenous co-administration of famotidine and pantoprazole to monotherapy with pantoprazole on intragastric pH in dogs. We hypothesized that single agent pantoprazole would be more effective than combination with famotidine.

Animals Twelve healthy adult colony dogs.

Methods Randomized, 2-way crossover design. All dogs received placebo (0.9% saline) for 24 hours followed by 1.0 mg/kg IV ...


Maintenance Energy Requirements Of Odor Detection, Explosive Detection And Human Detection Working Dogs, Rebecca A. Mullis, Angela L. Witzel, Joshua Price 2015 University of Tennessee - Knoxville

Maintenance Energy Requirements Of Odor Detection, Explosive Detection And Human Detection Working Dogs, Rebecca A. Mullis, Angela L. Witzel, Joshua Price

Angela L Witzel (Lusby) DVM, PhD, DACVN

Despite their important role in security, little is known about the energy requirements of working dogs such as odor, explosive and human detection dogs. Previous researchers have evaluated the energy requirements of individual canine breeds as well as dogs in exercise roles such as sprint racing. This study is the first to evaluate the energy requirements of working dogs trained in odor, explosive and human detection. This retrospective study evaluated twenty adult dogs who maintained consistent body weights over a six month period. During this time, the average energy consumption was [Formula: see text] or two times the calculated resting ...


Repeated Stressors In Adulthood Increase The Rate Of Biological Ageing, James S. Adelman, Michaela Hau, Mark F. Haussmann, Timothy J. Greives, Christa Matlack, David Costantini, Michael Quetting, Ana C. Miranda, Jesko Partecke 2015 Virginia Polytechnic Institute and State University

Repeated Stressors In Adulthood Increase The Rate Of Biological Ageing, James S. Adelman, Michaela Hau, Mark F. Haussmann, Timothy J. Greives, Christa Matlack, David Costantini, Michael Quetting, Ana C. Miranda, Jesko Partecke

James S. Adelman

Individuals of the same age can differ substantially in the degree to which they have accumulated tissue damage, akin to bodily wear and tear, from past experiences. This accumulated tissue damage reflects the individual’s biological age and may better predict physiological and behavioural performance than the individual‘s chronological age. However, at present it remains unclear how to reliably assess biological age in individual wild vertebrates. We exposed hand-raised adult Eurasian blackbirds (Turdus merula) to a combination of repeated immune and disturbance stressors for over one year to determine the effects of chronic stress on potential biomarkers of biological ...


A Comparison Of The Genetic Factors Influencing Host Response To Infection With One Of Two Isolates Of Porcine Reproductive And Respiratory Syndrome Virus, Andrew S. Hess, Nicholas Boddicker, Bob Rowland, Joan Lunney, Graham Plastow, Jack C. M. Dekkers 2015 Iowa State University

A Comparison Of The Genetic Factors Influencing Host Response To Infection With One Of Two Isolates Of Porcine Reproductive And Respiratory Syndrome Virus, Andrew S. Hess, Nicholas Boddicker, Bob Rowland, Joan Lunney, Graham Plastow, Jack C. M. Dekkers

Animal Industry Report

Host genetic differences in viral load (VL) and weight gain (WG) during porcine reproductive and respiratory syndrome virus (PRRSV) challenge were assessed for thirteen trials of ~200 commercial crossbred piglets each, from several different commercial suppliers. Piglets were experimentally infected with PRRSV isolates NVSL-97-7895 (NVSL) or KS-2006-72109 (KS06). VL and WG were moderately heritable and were antagonistically related for both virus isolates. The genetic correlation of host response to NVSL with host response to KS06 was high for both VL and WG. Consistent with previous findings, animals that were heterozygous (AB) for the WUR10000125 (WUR) marker on Chromosome 4 (SSC4 ...


Survey-Based Examination Of Demographics, Potential Causes And Treatments Of Aberrant Behavior Syndrome(Berserk Male Syndrome) In Camelids, Stephen R. Ball, Katherine Way, Jennifer A. Schleining, Suzanne T. Millman 2015 Iowa State University

Survey-Based Examination Of Demographics, Potential Causes And Treatments Of Aberrant Behavior Syndrome(Berserk Male Syndrome) In Camelids, Stephen R. Ball, Katherine Way, Jennifer A. Schleining, Suzanne T. Millman

Animal Industry Report

The objective of this study was to examine potential signs, causal factors and treatment interventions for camelids displaying Aberrant Behavior Syndrome (ABS), also known as Berserk Male Syndrome. A survey was developed for camelid owners and veterinarians with camelid experience using Survey Monkey software. Respondents were asked to describe the behaviors associated with the most recent case of ABS they were involved with, information about the animal displaying ABS, and evaluation of the efficacy of treatment interventions used. The majority of respondents identified a general demographic of an intact male camelid raised by its biological mother with daily or weekly ...


Accuracy Of Genomic Prediction For Prrs Antibody Response, Nick V. L. Serão, Bob Kemp, Benny Mote, Philip Willson, John Harding, Steve Bishop, Graham Plastow, Jack C. M. Dekkers 2015 Iowa State University

Accuracy Of Genomic Prediction For Prrs Antibody Response, Nick V. L. Serão, Bob Kemp, Benny Mote, Philip Willson, John Harding, Steve Bishop, Graham Plastow, Jack C. M. Dekkers

Animal Industry Report

The accuracy of genomic prediction for antibody response to Porcine Reproductive and Respiratory Syndrome (PRRS), measured as S/P ratio, was evaluated using two independent datasets of Landrace x Large White females. Results demonstrate that antibody response during a PRRS outbreak can be predicted with high accuracy using genetic markers in two regions on chromosome 7. One of these regions includes the Major Histocompatibility Complex. The high accuracy for this region indicates that marker effects are consistent across Landrace x Large White populations.


Kisspeptin Receptor Agonist (Ftm080) Increased Plasma Concentrations Of Luteinizing Hormone In Anestrous Ewes, Brian K. Whitlock, Joseph A. Daniel, Lisa L. Amelse, Valeria M. Tanco, Kelly A. Chameroy, F Neal Shrick 2015 University of Tennessee - Knoxville

Kisspeptin Receptor Agonist (Ftm080) Increased Plasma Concentrations Of Luteinizing Hormone In Anestrous Ewes, Brian K. Whitlock, Joseph A. Daniel, Lisa L. Amelse, Valeria M. Tanco, Kelly A. Chameroy, F Neal Shrick

Valeria M Tanco

Kisspeptin receptor (KISS1R) agonists with increased half-life and similar efficacy to kisspeptin in vitro may provide beneficial applications in breeding management of many species. However, many of these agonists have not been tested in vivo. These studies were designed to test and compare the effects of a KISS1R agonist (FTM080) and kisspeptin on luteinizing hormone (LH) in vivo. In experiment 1 (pilot study), sheep were treated with FTM080 (500 pmol/kg BW) or sterile water (VEH) intravenosuly. Blood was collected every 15 min before (1 hr) and after (1 hr) treatment. In experiment 2, sheep were treated with KP-10 (human ...


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