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Pharmacokinetics Of Single Feeding Of Cannabidiol In Cattle: A Pilot Study, Haley Cornette 2023 Murray State University

Pharmacokinetics Of Single Feeding Of Cannabidiol In Cattle: A Pilot Study, Haley Cornette

Honors College Theses

Cannabidiol (CBD) is a substance that has been used in complementary medicine for many years. However, modern medicine has little knowledge of how this substance is utilized and metabolized in ruminant animals. Regulations on quality assurance and use in animals are lacking, and CBD supplementation in livestock is not approved. If CBD supplements can be shown to be safe and effective, detection in the animal will be important for determining regulation of use. A withdrawal period can then be established to allow time for deterioration of product to safe levels before livestock products enter human markets. This study sought to ...


Equine Kinesiology Tape Application To Equine Hock Joints: Impact On Lameness And Movement Evaluation, Kiara Jones 2022 Murray State University

Equine Kinesiology Tape Application To Equine Hock Joints: Impact On Lameness And Movement Evaluation, Kiara Jones

Honors College Theses

Discomfort in the hocks of horses can cause lameness, resulting in poor performance. Diagnosis by veterinarians typically includes evaluating movement or use of ultrasound or radiography to evaluate tendons, ligaments, or bones. Treatment methods and times vary depending on diagnosis, but often include joint injections, medications, and stall rest. Treatments can be costly both financially and regarding time off from practice or competition. Alternative practices such as using equine kinesiology tape to support joints may improve comfort and movement for lower cost. The objective of this project was to evaluate the ease of use and effects of equine kinesiology tape ...


Validation Of A Method For Pantoprazole And Its Sulfone Metabolite In Goat Plasma Using High Performance Liquid Chromatography, Sherry Cox, Lainey Harvill, Sarah Bullock, Joseph Smith, Joan Bergman 2022 UTK

Validation Of A Method For Pantoprazole And Its Sulfone Metabolite In Goat Plasma Using High Performance Liquid Chromatography, Sherry Cox, Lainey Harvill, Sarah Bullock, Joseph Smith, Joan Bergman

Faculty Publications and Other Works -- Large Animal Clinical Sciences

No abstract provided.


Making The Case: Adding A Social Work Perspective To A Case Study In A Veterinary Practice, Paula Gerstenblatt, Diane Rhodes, Dorothea Ivey 2022 University of Southern Maine

Making The Case: Adding A Social Work Perspective To A Case Study In A Veterinary Practice, Paula Gerstenblatt, Diane Rhodes, Dorothea Ivey

People and Animals: The International Journal of Research and Practice

This article describes a case study exploration of a veterinary practice from the perspective of social work. Recognizing the stressful work of veterinary providers, including compassion fatigue and high suicide rates, the current study identified both a need for and the potential role of social workers in veterinary practice. Professionals were interviewed in an emergency/specialty practice. Using the interview data, the authors built a demonstrative case that underlines the vulnerability of veterinary professionals and the potential of social work to improve the quality of their work experiences and longevity.


Understanding The Causative Agent, Pathophysiology And Management Of The Kentucky Mare Reproductive Loss Syndrome And Related Syndromes, Thomas Tobin, Gabriel Volpato, Navid Yousefi-Mashouf, Kimberly Brewer 2022 University of Kentucky

Understanding The Causative Agent, Pathophysiology And Management Of The Kentucky Mare Reproductive Loss Syndrome And Related Syndromes, Thomas Tobin, Gabriel Volpato, Navid Yousefi-Mashouf, Kimberly Brewer

Maxwell H. Gluck Equine Research Center Faculty Presentations

No abstract provided.


Divergent Neural And Endocrine Responses In Wild-Caught And Laboratory-Bred Rattus Norvegicus, Joanna Jacob, Sally Watanabe, Jonathan Richardson, Nick Gonzales, Emily Ploppert, Garet Lahvis, Aaron Shiels, Sadie Wenger, Kelly Saverino, Janhavi Bhalerao, Brendan Crockett, Erin Burns, Olivia Harding, Krista Fischer-Stenger, Kelly Lambert 2022 University of Richmond

Divergent Neural And Endocrine Responses In Wild-Caught And Laboratory-Bred Rattus Norvegicus, Joanna Jacob, Sally Watanabe, Jonathan Richardson, Nick Gonzales, Emily Ploppert, Garet Lahvis, Aaron Shiels, Sadie Wenger, Kelly Saverino, Janhavi Bhalerao, Brendan Crockett, Erin Burns, Olivia Harding, Krista Fischer-Stenger, Kelly Lambert

USDA Wildlife Services - Staff Publications

Although rodents have represented the most intensely studied animals in neurobiological investigations for more than a century, few studies have systematically compared neural and endocrine differences between wild rodents in their natural habitats and laboratory strains raised in traditional laboratory environments. In the current study, male and female Rattus norvegicus rats were trapped in an urban setting and compared to weight-and sex-matched conspecifics living in standard laboratory housing conditions. Brains were extracted for neural assessments and fecal boli were collected for endocrine [corticosterone and dehydroepiandrosterone (DHEA)] assays. Additionally, given their role in immune and stress functions, spleen and adrenal weights ...


Clinical Ophthalmic Parameters Of The Quaker Parrot (Myiopsitta Monachus), Emily Halsmer, Jennifer Jill Heatley MS, DVM, DABVP (Avian, Reptilian, Amphibian), DACZM, Erin M. Scott DVM, DACVO 2022 Lincoln Memorial University

Clinical Ophthalmic Parameters Of The Quaker Parrot (Myiopsitta Monachus), Emily Halsmer, Jennifer Jill Heatley Ms, Dvm, Dabvp (Avian, Reptilian, Amphibian), Daczm, Erin M. Scott Dvm, Dacvo

Research Day

Purpose: Ophthalmic diagnosis in many avian species remains hindered by lack of normative values. This study aimed to establish normal ophthalmic parameters for select diagnostic tests in clinically normal Quaker parrots. Methods: Ninety-six captive Quaker parrots ages 8-18 years underwent ophthalmic examination to include assessment of neuro-ophthalmic reflexes, phenol red thread test, rebound tonometry, fluorescein staining, palpebral fissure length measurements, slit lamp biomicroscopy, indirect fundoscopy, and ocular ultrasound biometry. Results: Menace response, dazzle reflex, and direct pupillary light reflex were present for all Quaker parrots. Tear production (mean ± SD) was 13.3 ± 4.0 mm/15 sec and intraocular pressure ...


Synthesis And Characterization Of D5-Barbarin For Use In Barbarin-Related Research, Sucheta Kudrimoti, Jacob Machin, Adedamola S. Arojojoye, Samuel G. Awuah, Rodney Eisenberg, Clara Fenger, George Maylin, Andreas F. Lehner, Thomas Tobin 2022 University of Kentucky

Synthesis And Characterization Of D5-Barbarin For Use In Barbarin-Related Research, Sucheta Kudrimoti, Jacob Machin, Adedamola S. Arojojoye, Samuel G. Awuah, Rodney Eisenberg, Clara Fenger, George Maylin, Andreas F. Lehner, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Based on structural similarities and equine administration experiments, Barbarin, 5-phenyl-2-oxazolidinethione from Brassicaceae plants, is a possible source of equine urinary identifications of aminorex, (R,S)-5-phenyl-4,5-dihydro-1,3-oxazol-2-amine, an amphetamine-related US Drug Enforcement Administration (DEA) controlled substance considered illegal in sport horses. We now report the synthesis and certification of d5-barbarin to facilitate research on the relationship between plant barbarin and such aminorex identifications. D5-barbarin synthesis commenced with production of d5-2-oxo-2-phenylacetaldehyde oxime (d5-oxime) from d5-acetophenone via butylnitrite in an ethoxide/ethanol solution. This d5-oxime was then reduced with ...


Ex Vivo Biomechanical Evaluation Of A Novel Screw For Tibial Plateau Leveling Osteotomy, William Seth Kettleman 2022 Mississippi State University

Ex Vivo Biomechanical Evaluation Of A Novel Screw For Tibial Plateau Leveling Osteotomy, William Seth Kettleman

Theses and Dissertations

Twelve pairs of cadaveric pelvic limbs were harvested from skeletally mature dogs. Tibias were randomly assigned pairwise to two study groups: locking buttress screw fixation (LBS) and bone-screw-fastener fixation (BSF). A tibial plateau leveling osteotomy (TPLO) was performed. Each specimen was positioned in a servohydraulic testing machine to simulate physiological orientation and loading at the mid-point of the stance phase at the walk. Cyclic loading was performed for 30,000 cycles at 4Hz with a peak-load of 1000N. The cyclic test was then continued by stepwise increasing the peak-load at a rate of 75N per 500 cycles until failure of ...


Ex Vivo Biomechanical Comparison Of A Novel Compression Screw Fastener And Traditional Ao Cortical Bone Screw For Fixation Of A Simulated Slab Fracture In The Equine Third Carpal Bone, Allison Salinger 2022 Mississippi State University

Ex Vivo Biomechanical Comparison Of A Novel Compression Screw Fastener And Traditional Ao Cortical Bone Screw For Fixation Of A Simulated Slab Fracture In The Equine Third Carpal Bone, Allison Salinger

Theses and Dissertations

Frontal plane slab fractures account for the majority of third carpal bone (C3) fractures in performance horses. Treatment is stabilization with an AO cortical screw. Complications are fragment splitting, fragment spinning, and irritation of dorsal soft tissue structures. A novel, headless, cannulated screw with interlocking threads (the Headless Compression Screw Fastener, HCSF) has been developed to resist multidirectional forces. Simulated C3 slab fractures were created in nine paired equine carpi. HCSF or AO cortical screws were loaded in shear to failure. Stiffness, maximum load to failure, and yield load was assessed in linear mixed models. No significant difference was detected ...


Impact Of Fatty Acid On Markers Of Exocrine Pancreatic Stimulation, Yunyi Zhang 2022 University of Tennessee, Knoxville

Impact Of Fatty Acid On Markers Of Exocrine Pancreatic Stimulation, Yunyi Zhang

Masters Theses

Chronic pancreatitis in dogs is typically managed with a low-fat diet. Human research suggests consuming medium-chain triglycerides (MCT) may lower pancreatic enzyme release compared to consuming long chain fatty acids (LCFA). Twelve healthy adult colony dogs were fed a meal of cod and rice with either 3% metabolizable energy (ME) fat (control), high MCT (25% ME MCT oil, 25% ME butter), high saturated LCFA (50% ME butter), or high unsaturated LCFA (50% ME canola oil) in a 4-period by 4-treatment crossover design. Serum concentrations of canine pancreatic lipase immunoreactivity, gastrin, amylase, cholecystokinin (CCK), cholesterol, triglycerides and serum activities of DGGR ...


In Vivo Efficacy Of Pyrantel Pamoate As A Post-Exposure Prophylactic For Rat Lungworm (Angiostrongylus Cantonensis), John Jacob, Argon Steel, Lisa Kaluna, Steven Hess, Israel Leinbach, Carmen Antaky, Robert Sugihara, Lindsey Hamilton, Peter Follett, Kathleen Howe, Steven Jacquier, Supakit Wongwiwatthananukit, Susan Jarvi 2022 University of Hawaii at Hilo

In Vivo Efficacy Of Pyrantel Pamoate As A Post-Exposure Prophylactic For Rat Lungworm (Angiostrongylus Cantonensis), John Jacob, Argon Steel, Lisa Kaluna, Steven Hess, Israel Leinbach, Carmen Antaky, Robert Sugihara, Lindsey Hamilton, Peter Follett, Kathleen Howe, Steven Jacquier, Supakit Wongwiwatthananukit, Susan Jarvi

USDA Wildlife Services - Staff Publications

Rat lungworm (Angiostrongylus cantonensis) is a neurotropic nematode, and the leading cause of eosinophilic meningitis worldwide. The parasite is usually contracted through ingestion of infected gastropods, often hidden in raw or partially cooked produce. Pharmaceutical grade pyrantel pamoate was evaluated as a post-exposure prophylactic against A. cantonensis. Pyrantel pamoate is readily available over-the-counter in most pharmacies in the USA and possesses anthelmintic activity exclusive to the gastrointestinal tract (GIT). Administering pyrantel pamoate immediately after exposure should theoretically paralyze the larvae in the GIT, causing the larvae to be expelled via peristalsis without entering the systemic circulation. In this study, pyrantel ...


Defining An Epidemiological Landscape That Connects Movement Ecology To Pathogen Transmission And Pace-Of-Life, Kezia Manlove, Mark Wilber, Lauren White, Guillaume Bastille-Rousseau, Anni Yang, Marie L.J. Gilbertson, Meggan E. Craft, Paul C. Cross, George Wittemyer, Kim M. Pepin 2022 Utah State University

Defining An Epidemiological Landscape That Connects Movement Ecology To Pathogen Transmission And Pace-Of-Life, Kezia Manlove, Mark Wilber, Lauren White, Guillaume Bastille-Rousseau, Anni Yang, Marie L.J. Gilbertson, Meggan E. Craft, Paul C. Cross, George Wittemyer, Kim M. Pepin

USDA Wildlife Services - Staff Publications

Pathogen transmission depends on host density, mobility and contact. These components emerge from host and pathogen movements that themselves arise through interactions with the surrounding environment. The environment, the emergent host and pathogen movements, and the subsequent patterns of density, mobility and contact form an ‘epidemiological landscape’ connecting the environment to specific locations where transmissions occur. Conventionally, the epidemiological landscape has been described in terms of the geographical coordinates where hosts or pathogens are located. We advocate for an alternative approach that relates those locations to attributes of the local environment. Environmental descriptions can strengthen epidemiological forecasts by allowing for ...


Current Ecotoxicity Testing Needs Among Selected U.S. Federal Agencies, Patricia Ceger, Natalia Garcia-Reyero Vinas, David Allen, Elyssa Arnold, Raanan Bloom, Jennifer C. Brennan, Carol Clarke, Karen Eisenreich, Kellie Fay, Jonathan Hamm, Paula F.P. Henry, Katherine E. Horak, Wesley Hunter, Donna Judkins, Patrice Klein, Nicole Kleinstreuer, Kara Koehrn, Carlie A. LaLone, James P. Laurenson, Jessica K. Leet, Anna Lowit, Scott G. Lynn, Teresa Norberg-King, Edward J. Perkins, Elijah J. Petersen, Barnett A. Rattner, Catherine S. Sprankle, Thomas Steeger, Jim E. Warren, Sarah Winfield, Edward Odenkirchen 2022 Integrated Laboratory Systems

Current Ecotoxicity Testing Needs Among Selected U.S. Federal Agencies, Patricia Ceger, Natalia Garcia-Reyero Vinas, David Allen, Elyssa Arnold, Raanan Bloom, Jennifer C. Brennan, Carol Clarke, Karen Eisenreich, Kellie Fay, Jonathan Hamm, Paula F.P. Henry, Katherine E. Horak, Wesley Hunter, Donna Judkins, Patrice Klein, Nicole Kleinstreuer, Kara Koehrn, Carlie A. Lalone, James P. Laurenson, Jessica K. Leet, Anna Lowit, Scott G. Lynn, Teresa Norberg-King, Edward J. Perkins, Elijah J. Petersen, Barnett A. Rattner, Catherine S. Sprankle, Thomas Steeger, Jim E. Warren, Sarah Winfield, Edward Odenkirchen

USDA Wildlife Services - Staff Publications

U.S. regulatory and research agencies use ecotoxicity test data to assess the hazards associated with substances that may be released into the environment, including but not limited to industrial chemicals, pharmaceuticals, pesticides, food additives, and color additives. These data are used to conduct hazard assessments and evaluate potential risks to aquatic life (e.g., invertebrates, fish), birds, wildlife species, or the environment. To identify opportunities for regulatory uses of non-animal replacements for ecotoxicity tests, the needs and uses for data from tests utilizing animals must first be clarified. Accordingly, the objective of this review was to identify the ecotoxicity ...


Understanding How High Levels Of Noise Affect The Equine Auditory System, Shelby Brown 2022 University of Northern Colorado

Understanding How High Levels Of Noise Affect The Equine Auditory System, Shelby Brown

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

Abstract

Mounted shooting is becoming a very popular sport within the equestrian community, exposing many horses to extreme levels of noise that the animals would not be exposed to otherwise. I selected this project because it is important for me to know how this hobby that I personally enjoy is impacting the health and well-being of my equine partners. Veterinarians can provide an elementary answer by clapping and checking for a physical reaction. However, that does not tell the client much other than the animal responded to one auditory cue.

It is important to understand how firearm exposure could affect ...


Comparative Susceptibility Of Eastern Cottontails And New Zealand White Rabbits To Classical Rabbit Haemorrhagic Disease Virus (Rhdv) And Rhdv2, Fawzi Mohamed, Thomas Gidlewski, Mary L. Berninger, Heather M. Petrowski, Alexa J. Bracht, Carla Bravo de Rueda, Roger W. Barrette, Meredith Grady, Emily S. O'Hearn, Charles E. Lewis, Karen E. Moran, Tracy L. Sturgill, Lorenzo Capucci, J. Jeffrey Root 2022 USDA ARS Plum Island Animal Disease Center

Comparative Susceptibility Of Eastern Cottontails And New Zealand White Rabbits To Classical Rabbit Haemorrhagic Disease Virus (Rhdv) And Rhdv2, Fawzi Mohamed, Thomas Gidlewski, Mary L. Berninger, Heather M. Petrowski, Alexa J. Bracht, Carla Bravo De Rueda, Roger W. Barrette, Meredith Grady, Emily S. O'Hearn, Charles E. Lewis, Karen E. Moran, Tracy L. Sturgill, Lorenzo Capucci, J. Jeffrey Root

USDA Wildlife Services - Staff Publications

Rabbit haemorrhagic disease virus (RHDV) is associated with high morbidity and mortality in the European rabbit (Oryctolagus cuniculus). In 2010, a genetically distinct RHDV named RHDV2 emerged in Europe and spread to many other regions, including North America in 2016. Prior to this study it was unknown if eastern cottontails (ECT(s); Sylvilagus floridanus), one of the most common wild lagomorphs in the United States, were susceptible to RHDV2. In this study, 10 wild-caught ECTs and 10 New Zealand white rabbits (NZWR(s); O. cuniculus) were each inoculated orally with either RHDV (RHDVa/GI.1a; n = 5 per species) or ...


Solar Radiation And Soil Moisture Drive Tropical Forest Understory Responses To Experimental And Natural Hurricanes, J. Aaron Hogan, Joanne M. Sharpe, Ashley Van Beusekom, Sarah Stankavich, Samuel Matta Carmona, John E. Bithorn, Jamarys Torres-Díaz, Grizelle González, Jess K. Zimmerman, Aaron B. Shiels 2022 Florida International University

Solar Radiation And Soil Moisture Drive Tropical Forest Understory Responses To Experimental And Natural Hurricanes, J. Aaron Hogan, Joanne M. Sharpe, Ashley Van Beusekom, Sarah Stankavich, Samuel Matta Carmona, John E. Bithorn, Jamarys Torres-Díaz, Grizelle González, Jess K. Zimmerman, Aaron B. Shiels

USDA Wildlife Services - Staff Publications

Tropical forest understory regeneration occurs rapidly after disturbance with compositional trajectories that depend on species availability and environmental conditions. To predict future tropical forest regeneration dynamics, we need a deeper understanding of how pulse disturbance events, like hurricanes, interact with environmental variability to affect understory demography and composition. We examined fern and sapling mortality, recruitment, and community composition in relation to solar radiation and soil moisture using 17 years of forest dynamics data (2003–2019) from the Canopy Trimming Experiment in the Luquillo Experimental Forest, Puerto Rico. Solar radiation increased 150% and soil moisture increased 40% following canopy trimming of ...


Physicochemical, Techno-Functional And Bioactive Properties Of Camel Whey Protein Concentrate As Affected By Spray-Drying And Ultrasonication Treatment, Alanoud Muhsen Al Thaibani 2022 United Arab Emirates University

Physicochemical, Techno-Functional And Bioactive Properties Of Camel Whey Protein Concentrate As Affected By Spray-Drying And Ultrasonication Treatment, Alanoud Muhsen Al Thaibani

Theses

Whey protein concentrates (WPCs) are gaining importance as functional ingredients due to their nutritional, techno-functional and bioactive properties. In this study, WPCs were prepared from skimmed camel milk, then either spray-dried (SD) at 170, 185 and 200°C or treated by ultrasonication (US) (20 kHz) for 5, 10 and 15 min followed by freeze-drying to obtain powders. The characterization of WPC powders was carried out by Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Reverse-Phase Ultra Performance Liquid Chromatography (RP-UPLC) which showed that the US treatment degraded the proteins more than SD. The morphology, particle size, and surface charge of WPC ...


Sporadic Worldwide “Clusters” Of Feed Driven Zilpaterol Identifications In Racing Horses: A Review And Analysis, Jacob Machin, Kimberly Brewer, Abelardo Morales Briceno, Clara Fenger, George Maylin, Thomas Tobin 2022 University of Kentucky

Sporadic Worldwide “Clusters” Of Feed Driven Zilpaterol Identifications In Racing Horses: A Review And Analysis, Jacob Machin, Kimberly Brewer, Abelardo Morales Briceno, Clara Fenger, George Maylin, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Zilpaterol is a β2-adrenergic agonist medication approved in certain countries as a cattle feed additive to improve carcass quality. Trace amounts of Zilpaterol can transfer to horse feed, yielding equine urinary “identifications” of Zilpaterol. These “identifications” occur because Zilpaterol is highly bioavailable in horses, resistant to biotransformation and excreted as unchanged Zilpaterol in urine, where it has a 5 day or so terminal half-life.

In horses, urinary steady-state concentrations are reached 25 days (5 half-lives) after exposure to contaminated feed. Zilpaterol readily presents in horse urine, yielding clusters of feed related Zilpaterol identifications in racehorses. The first cluster, April ...


Comparison Of Abdominal Computed Tomography To Ultrasound In The Diagnosis Of Canine Biliary Disease Manifesting As Acute Abdominal Signs, Shanna Christine Marroquin 2022 Mississippi State University

Comparison Of Abdominal Computed Tomography To Ultrasound In The Diagnosis Of Canine Biliary Disease Manifesting As Acute Abdominal Signs, Shanna Christine Marroquin

Theses and Dissertations

Biliary diseases are uncommon, potentially fatal causes of acute abdomen in dogs. Little information is present comparing the performance of computed tomography (CT) to ultrasound in identifying canine biliary pathology. Thirty-five client-owned dogs presenting for acute abdomen signs received an abdominal ultrasound and contrast-enhanced abdominal CT. Two authors reviewed the randomized, anonymized CT and ultrasound studies. Twenty-eight dogs had biliary pathology and seven dogs serving as controls had no evidence of biliary disease. The final diagnoses of patients with biliary pathology included cholelithiasis, gallbladder mucoceles, cholangiohepatitis/cholangitis, extrahepatic biliary obstruction, gallbladder wall edema, gallbladder wall mass, and cystic mucosal hyperplasia ...


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