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Characterization And Manipulation Of O-Glcnacylation In Granulosa Cells Of Bovine Ovarian Antral Follicles, Abigail Marie Maucieri 2022 University of Vermont

Characterization And Manipulation Of O-Glcnacylation In Granulosa Cells Of Bovine Ovarian Antral Follicles, Abigail Marie Maucieri

Graduate College Dissertations and Theses

Glucose is widely recognized as the preferred energy substrate for metabolism by granulosa cells (GCs). Yet in most cells, 2-5% of glucose is shunted through the hexosamine biosynthesis pathway (HBP) for O-linked N-acetylglucosaminylation (O-GlcNAcylation). O-GlcNAcylation is an evolutionarily-conserved, post-translational process that modifies serine and threonine residues on a variety of proteins. O-GlcNAcylation is also considered a nutrient sensor that can regulate cellular processes such as metabolism, signal transduction, and proliferation. In this respect, O-GlcNAcylation may be similar to, and possibly mediate, AMP-activated protein kinase (AMPK) signaling and its nutrient-sensing actions. However, the occurrence of O-GlcNAcylation and its relative importance to ...


Impact Of Fish Oil On Intestinal Permeability, Inflammation, And Performance In Swine, Anthony Fernando Alberto 2021 Utah State University

Impact Of Fish Oil On Intestinal Permeability, Inflammation, And Performance In Swine, Anthony Fernando Alberto

All Graduate Theses and Dissertations

Our research examined the effects of fish oil supplementation on intestinal permeability, systemic inflammation and performance in piglets. An lipopolysaccharide (LPS) challenge was done to stimulate the synthesis and release of the cytokines, in an effort to mimic the immune response that piglets would have when facing stress or pathogen challenge. Fish oil increased feed intake but did not affect growth when compared to control. Total fatty acid digestibility increased by 6% when fish oil was included in the diet. Also, we observed a 16% increase on 16-carbon fatty acids digestibility. Fish oil did not affect the plasma D-xylose concentration ...


Supplement: A Field Trial Of 2 Point Of Care Glucometers In Healthy Calves, Joseph Smith, Lisa Ebner, Haley Cremerius, Channing Cantrell, Windy Soto-Gonzalez, Rebecca Rahn, Jon P. Mochel, Jeff Olivarez, Amanda Kreuder 2021 UTK

Supplement: A Field Trial Of 2 Point Of Care Glucometers In Healthy Calves, Joseph Smith, Lisa Ebner, Haley Cremerius, Channing Cantrell, Windy Soto-Gonzalez, Rebecca Rahn, Jon P. Mochel, Jeff Olivarez, Amanda Kreuder

Faculty Publications and Other Works -- Large Animal Clinical Sciences

No abstract provided.


Pharmacokinetics Of Tulathromycin In Pregnant Ewes (Ovis Aries) Challenged With Campylobacter Jejuni, Michael Yaeger, Jonathan P. Mochel, Zuowei Wu, Paul Plummer, Orhan Sahin, Joseph Smith, Melda Ocal, Ashenafi Beyi, Changyun Xu, Qijing Zhang, Ronald W. Griffith 2021 Iowa State University

Pharmacokinetics Of Tulathromycin In Pregnant Ewes (Ovis Aries) Challenged With Campylobacter Jejuni, Michael Yaeger, Jonathan P. Mochel, Zuowei Wu, Paul Plummer, Orhan Sahin, Joseph Smith, Melda Ocal, Ashenafi Beyi, Changyun Xu, Qijing Zhang, Ronald W. Griffith

Faculty Publications and Other Works -- Large Animal Clinical Sciences

The purpose of this study was to evaluate the pharmacokinetics of tulathromycin in the plasma and maternal and fetal tissues of pregnant ewes when administered within 24 hours of a single, IV Campylobacter jejuni (C. jejuni) challenge. Twelve, pregnant ewes between 72–92 days of gestation were challenged IV with C. jejuni IA3902 and then treated with 1.1 ml/45.36 kg of tulathromycin subcutaneously 18 hours post-challenge. Ewes were bled at predetermined time points and euthanized either at a predetermined time point or following the observation of vaginal bleeding or abortion. Following euthanasia, tissues were collected for bacterial ...


Equine Influenza Virus And Vaccines, Fatai S. Oladunni, Saheed Oluwasina Oseni, Luis Martinez-Sobrido, Thomas M. Chambers 2021 Texas Biomedical Research Institute

Equine Influenza Virus And Vaccines, Fatai S. Oladunni, Saheed Oluwasina Oseni, Luis Martinez-Sobrido, Thomas M. Chambers

Veterinary Science Faculty Publications

Equine influenza virus (EIV) is a constantly evolving viral pathogen that is responsible for yearly outbreaks of respiratory disease in horses termed equine influenza (EI). There is currently no evidence of circulation of the original H7N7 strain of EIV worldwide; however, the EIV H3N8 strain, which was first isolated in the early 1960s, remains a major threat to most of the world’s horse populations. It can also infect dogs. The ability of EIV to constantly accumulate mutations in its antibody-binding sites enables it to evade host protective immunity, making it a successful viral pathogen. Clinical and virological protection against ...


Short-Term Transport Stress And Supplementation Alter Immune Function In Aged Horses, Ashton B. Miller, Patricia A. Harris, Virginia D. Barker, Amanda A. Adams 2021 University of Kentucky

Short-Term Transport Stress And Supplementation Alter Immune Function In Aged Horses, Ashton B. Miller, Patricia A. Harris, Virginia D. Barker, Amanda A. Adams

Veterinary Science Faculty Publications

Long-distance transport is associated with stress-related changes in equine immune function, and shipping-associated illnesses are often reported. Horses are frequently transported short distances, yet the effects of short-term transport on immune function remain largely unknown. Twelve horses, aged 15–30 yr, were assigned to either the control (n = 6) or treatment (n = 6) groups; treatment horses received a daily antioxidant supplement 3 weeks before and after transport. All horses were transported for approximately 1.5–2 hr on Day 0. Blood was collected via jugular venipuncture at 15-min pre- and post-transport and on Days –21, 1, 3, 7, 14, and ...


Retrospective Evaluation Of A Dose-Dependent Effect Of Angiotensin-Converting Enzyme Inhibitors On Long-Term Outcome In Dogs With Cardiac Disease, Jessica L. Ward, Yen-Yu Chou, Lingnan Yuan, Karin S. Dorman, Jonathan P. Mochel 2021 Iowa State University

Retrospective Evaluation Of A Dose-Dependent Effect Of Angiotensin-Converting Enzyme Inhibitors On Long-Term Outcome In Dogs With Cardiac Disease, Jessica L. Ward, Yen-Yu Chou, Lingnan Yuan, Karin S. Dorman, Jonathan P. Mochel

Veterinary Clinical Sciences Publications

Background: Angiotensin-converting enzyme inhibitors (ACEIs) are commonly prescribed in dogs, but the ideal dosage is unknown.

Hypothesis/Objectives: In dogs with cardiac disease, a dose-response relationship exists for ACEIs with respect to long-term outcome.

Animals: One hundred forty-four dogs with cardiac disease, 63 with current or prior congestive heart failure.

Methods: Retrospective medical record review. Cox proportional hazards models were used to determine variables associated with 2-year survival or survival from first-onset congestive heart failure (CHF).

Results: Median initial ACEI dosage was 0.84 (interquartile range [IQR], 0.56-0.98) mg/kg/day, and 108/144 (75%) of dogs received ...


Complex Feline Disease Mapping Using A Dense Genotyping Array [Preprint], Isabel Hernandez, Jessica J. Hayward, Michelle E. White 2021 Cornell University

Complex Feline Disease Mapping Using A Dense Genotyping Array [Preprint], Isabel Hernandez, Jessica J. Hayward, Michelle E. White

University of Massachusetts Medical School Faculty Publications

The current feline genotyping array of 63k single nucleotide polymorphisms has proven its utility within breeds, and its use has led to the identification of variants associated with Mendelian traits in purebred cats. However, compared to single gene disorders, association studies of complex diseases, especially with the inclusion of random bred cats with relatively low linkage disequilibrium, require a denser genotyping array and an increased sample size to provide statistically significant associations. Here, we undertook a multi-breed study of 1,122 cats, most of which were admitted and phenotyped for nine common complex feline diseases at the Cornell University Hospital ...


Steroidogenic Enzyme And Steroid Receptor Expression In The Equine Accessory Sex Glands, Robyn E. Ellerbrock, Giorgia Podico, Kirsten E. Scoggin, Barry A. Ball, Mariano Carossino, Igor F. Canisso 2021 University of Illinois Urbana-Champaign

Steroidogenic Enzyme And Steroid Receptor Expression In The Equine Accessory Sex Glands, Robyn E. Ellerbrock, Giorgia Podico, Kirsten E. Scoggin, Barry A. Ball, Mariano Carossino, Igor F. Canisso

Maxwell H. Gluck Equine Research Center Faculty Publications

The expression pattern and distribution of sex steroid receptors and steroidogenic enzymes during development of the equine accessory sex glands has not previously been described. We hypothesized that equine steroidogenic enzyme and sex steroid receptor expression is dependent on reproductive status. Accessory sex glands were harvested from mature stallions, pre-pubertal colts, geldings, and fetuses. Expression of mRNA for estrogen receptor 1 (ESR1), estrogen receptor 2 (ESR2), androgen receptor (AR), 3β-Hydroxysteroid dehydrogenase/Δ5-4 isomerase (3βHSD), P450,17α hydroxylase, 17–20 lyase (CYP17), and aromatase (CYP19) were quantified by RT-PCR, and protein localization of AR, ER-α, ER-β, and 3βHSD were investigated by ...


First Molecular Detection Of Hepatitis E Virus Genome In Camel And Pig Faecal Samples In Ethiopia, Fufa Dawo Bari, Haimanot Belete Wodaje, Umar Said, Hika Waktole, Melaku Sombo, Samson Leta, Tesfaye Rufael Chibsa, Paul J. Plummer 2021 Addis Ababa University

First Molecular Detection Of Hepatitis E Virus Genome In Camel And Pig Faecal Samples In Ethiopia, Fufa Dawo Bari, Haimanot Belete Wodaje, Umar Said, Hika Waktole, Melaku Sombo, Samson Leta, Tesfaye Rufael Chibsa, Paul J. Plummer

Veterinary Diagnostic and Production Animal Medicine Publications

Background: Hepatitis E is an enteric and zoonotic disease caused by hepatitis E virus (HEV) that is mainly transmitted via the faecal-oral route through contaminated food or the environment. The virus is an emerging infectious agent causing acute human infection worldwide. A high seroprevalence of the disease was reported in pregnant women in Addis Ababa, Ethiopia, raising significant public health concern. The presence of HEV specific antibodies were also reported in dromedary camels in the country; however, the infectious virus and/or the viral genome have not been demonstrated to date in animal samples.

Methods: To address this gap, a ...


Self-Assembling Synthetic Nanoadjuvant Scaffolds Cross-Link B Cell Receptors And Represent New Platform Technology For Therapeutic Antibody Production, Sujata Senapati, Ross J. Darling, Kathleen A. Ross, Michael J. Wannemeuhler, Balaji Narasimhan, Surya K. Mallapragada 2021 Iowa State University

Self-Assembling Synthetic Nanoadjuvant Scaffolds Cross-Link B Cell Receptors And Represent New Platform Technology For Therapeutic Antibody Production, Sujata Senapati, Ross J. Darling, Kathleen A. Ross, Michael J. Wannemeuhler, Balaji Narasimhan, Surya K. Mallapragada

Chemical and Biological Engineering Publications

Host antibody responses are pivotal for providing protection against infectious agents. We have pioneered a new class of self-assembling micelles based on pentablock copolymers that enhance antibody responses while providing a low inflammatory environment compared to traditional adjuvants. This type of “just-right” immune response is critical in the rational design of vaccines for older adults. Here, we report on the mechanism of enhancement of antibody responses by pentablock copolymer micelles, which act as scaffolds for antigen presentation to B cells and cross-link B cell receptors, unlike other micelle-forming synthetic block copolymers. We exploited this unique mechanism and developed these scaffolds ...


The Pathology Of Natural And Experimentally Induced Campylobacter Jejuni Abortion In Sheep, Michael J. Yaeger, Orhan Sahin, Paul J. Plummer, Zuowei Wu, Judith A. Stasko, Qijing Zhang 2021 Iowa State University

The Pathology Of Natural And Experimentally Induced Campylobacter Jejuni Abortion In Sheep, Michael J. Yaeger, Orhan Sahin, Paul J. Plummer, Zuowei Wu, Judith A. Stasko, Qijing Zhang

Veterinary Microbiology and Preventive Medicine Publications

We describe here the gross and microscopic lesions in 18 experimentally induced and 120 natural Campylobacter abortions. In natural Campylobacter abortions, gross lesions were reported infrequently; placentitis was recorded in 6% and hepatic lesions in 4% of our field cases. Placentitis was the microscopic lesion identified most consistently in natural abortions (93%) and was often observed in association with abundant bacterial colonies in chorionic villi (54%) and less often with placental vasculitis (13%). In natural abortions, suppurative fetal pneumonia (48%), necrosuppurative hepatitis (16%), and purulent meningitis (7%) were also observed. The better-preserved specimens from experimentally induced abortions were utilized to ...


Cranial Cruciate Ligament Desmotomies In Sheep Resulting In Peroneus Tertius Injury, Peter J. Welsh, Crystal G. Collier, Holly M. Clement, Michael N. Vakula, Jeffrey B. Mason 2021 Utah State University

Cranial Cruciate Ligament Desmotomies In Sheep Resulting In Peroneus Tertius Injury, Peter J. Welsh, Crystal G. Collier, Holly M. Clement, Michael N. Vakula, Jeffrey B. Mason

Animal, Dairy, and Veterinary Science Student Research

Surgical destabilization of the stifle joint via cranial cruciate ligament desmotomy (CCLD) is a routine procedure for the study of osteoarthritis (OA). Traditionally performed in rats, rabbits, cats, and dogs, CCLD in sheep provides an opportunity to study the pathology and treatment of joint instability in a species whose stifle better represents the equivalent human femorotibial joint. The surgical approaches for CCLD in sheep are variable and can result in inconsistent outcomes. Eight sheep underwent CCLD for use in a gene therapy study. We report this case in which six of the eight sheep were clinically diagnosed by pathognomonic signs ...


Nonlinear Mixed-Effect Pharmacokinetic Modeling And Distribution Of Doxycycline In Healthy Female Donkeys After Multiple Intragastric Dosing–Preliminary Investigation, Ronan J.J. Chapuis, Joseph Smith, Hilari M. French, Felix Ngosa Toka, Erik W. Peterson, Erika L. Little 2021 Ross University School of Veterinary Medicine

Nonlinear Mixed-Effect Pharmacokinetic Modeling And Distribution Of Doxycycline In Healthy Female Donkeys After Multiple Intragastric Dosing–Preliminary Investigation, Ronan J.J. Chapuis, Joseph Smith, Hilari M. French, Felix Ngosa Toka, Erik W. Peterson, Erika L. Little

Faculty Publications and Other Works -- Large Animal Clinical Sciences

Doxycycline (DXC) is a broad-spectrum antibacterial antimicrobial administered to horses for the treatment of bacterial infections which may also affect donkeys. Donkeys have a different metabolism than horses, leading to differences in the pharmacokinetics of drugs compared to horses. This study aimed to describe the population pharmacokinetics of DXC in donkeys. Five doses of DXC hyclate (10 mg/kg) were administered via a nasogastric tube, q12 h, to eight non-fasted, healthy, adult jennies. Serum, urine, synovial fluid and endometrium were collected for 72 h following the first administration. Doxycycline concentration was measured by competitive enzyme immunoassay. Serum concentrations versus time ...


Identification Of A Ruminant Origin Group B Rotavirus Associated With Diarrhea Outbreaks In Foals, Tirth Uprety, Chithra C. Sreenivasan, Ben M. Hause, Ganwu Li, Solomon O. Odemuyiwa, Stephen Locke, Jocelynn Morgan, Li Zeng, William F. Gilsenan, Nathan Slovis, Laurie Metcalfe, Craig N. Carter, Peter J. Timoney, David W. Horohov, Dan Wang, Erdal Erol, Emma Adam, Feng Li 2021 University of Kentucky

Identification Of A Ruminant Origin Group B Rotavirus Associated With Diarrhea Outbreaks In Foals, Tirth Uprety, Chithra C. Sreenivasan, Ben M. Hause, Ganwu Li, Solomon O. Odemuyiwa, Stephen Locke, Jocelynn Morgan, Li Zeng, William F. Gilsenan, Nathan Slovis, Laurie Metcalfe, Craig N. Carter, Peter J. Timoney, David W. Horohov, Dan Wang, Erdal Erol, Emma Adam, Feng Li

Maxwell H. Gluck Equine Research Center Faculty Publications

Equine rotavirus group A (ERVA) is one of the most common causes of foal diarrhea. Starting in February 2021, there was an increase in the frequency of severe watery to hemorrhagic diarrhea cases in neonatal foals in Central Kentucky. Diagnostic investigation of fecal samples failed to detect evidence of diarrhea-causing pathogens including ERVA. Based on Illumina-based metagenomic sequencing, we identified a novel equine rotavirus group B (ERVB) in fecal specimens from the affected foals in the absence of any other known enteric pathogens. Interestingly, the protein sequence of all 11 segments had greater than 96% identity with group B ...


Transcriptomic Analysis Of Equine Chorioallantois Reveals Immune Networks And Molecular Mechanisms Involved In Nocardioform Placentitis, Hossam El-Sheikh Ali, Shavahn C. Loux, Laura Kennedy, Kirsten E. Scoggin, Pouya Dini, Carleigh E. Fedorka, Ted S. Kalbfleisch, Alejandro Esteller-Vico, David W. Horohov, Erdal Erol, Craig N. Carter, Jackie L. Smith, Barry A. Ball 2021 University of Kentucky

Transcriptomic Analysis Of Equine Chorioallantois Reveals Immune Networks And Molecular Mechanisms Involved In Nocardioform Placentitis, Hossam El-Sheikh Ali, Shavahn C. Loux, Laura Kennedy, Kirsten E. Scoggin, Pouya Dini, Carleigh E. Fedorka, Ted S. Kalbfleisch, Alejandro Esteller-Vico, David W. Horohov, Erdal Erol, Craig N. Carter, Jackie L. Smith, Barry A. Ball

Maxwell H. Gluck Equine Research Center Faculty Publications

Nocardioform placentitis (NP) continues to result in episodic outbreaks of abortion and preterm birth in mares and remains a poorly understood disease. The objective of this study was to characterize the transcriptome of the chorioallantois (CA) of mares with NP. The CA were collected from mares with confirmed NP based upon histopathology, microbiological culture and PCR for Amycolatopsis spp. Samples were collected from the margin of the NP lesion (NPL, n = 4) and grossly normal region (NPN, n = 4). Additionally, CA samples were collected from normal postpartum mares (Control; CRL, n = 4). Transcriptome analysis identified 2892 differentially expressed genes (DEGs ...


Swine Disease Reporting System Report #41, Giovani Trevisan, Daniel Linhares, Edison Magalhaes, Bret Crim, Poonam Dubey, Kent J. Schwartz, Eric Burrough, Phillip Gauger, Pablo Pineyro, Christopher Siepker, Rodger G. Main, Mary Thurn, Paulo Lages, Cesar Corzo, Jerry Torrison, Rob McGaughey, Eric Herrman, Roman Pogranichniy, Rachel Palinski, Jamie Henningson, Jon Greseth, Darren Kersey, Travis Clement, Jane Christopher-Hennings 2021 Iowa State University

Swine Disease Reporting System Report #41, Giovani Trevisan, Daniel Linhares, Edison Magalhaes, Bret Crim, Poonam Dubey, Kent J. Schwartz, Eric Burrough, Phillip Gauger, Pablo Pineyro, Christopher Siepker, Rodger G. Main, Mary Thurn, Paulo Lages, Cesar Corzo, Jerry Torrison, Rob Mcgaughey, Eric Herrman, Roman Pogranichniy, Rachel Palinski, Jamie Henningson, Jon Greseth, Darren Kersey, Travis Clement, Jane Christopher-Hennings

Swine Disease Reporting System

What is the Swine Disease Reporting System (SDRS)? SDRS includes multiple projects that aggregate data from participating veterinary diagnostic laboratories (VDLs) in the United States of America (USA), and reports the major findings to the swine industry. Our goal is to share information on endemic and emerging diseases affecting the swine population in the USA, assisting veterinarians and producers in making informed decisions on disease prevention, detection, and management.

After aggregating information from participating VDLs and summarizing the data, we ask the input of our advisory group, which consists of veterinarians and producers across the USA swine industry. The intent ...


Melanoma Maligno Cutáneo Con Metástasis Sistémica En Una Hembra De Tigre De Bengala Blanca (Panthera Tigris Tigris), Gustavo Adolfo González González, Hedlly Vanessa Centeno Aldana 2021 Universidad de San Carlos de Guatemala

Melanoma Maligno Cutáneo Con Metástasis Sistémica En Una Hembra De Tigre De Bengala Blanca (Panthera Tigris Tigris), Gustavo Adolfo González González, Hedlly Vanessa Centeno Aldana

Revista de Medicina Veterinaria

La presencia del melanoma maligno cutáneo en felinos exóticos está pobremente reportada. Una hembra de tigre de Bengala blanca (Panthera tigris tigris), de 6 años, no castrada, solitaria y viviendo en un ambiente adecuado, fue evaluada por la presencia de una masa cerca del ojo izquierdo. La histopatología de la biopsia remitida mostró la presencia de melanocitos con características anaplásicas (pleomorfismo, citomegalia, cariomegalia, binucleación), área hemorrágica y foco inflamatorio fibrinoso. El diagnóstico histopatológico fue melanoma maligno. Dos meses después del diagnóstico, la tigresa manifestó un deterioro considerable con pérdida de peso y presencia de una masa redonda en el cuello ...


Investigating The Relationship Of Porcine Reproductive And Respiratory Syndrome Virus Rna Detection Between Adult/Sow Farm And Wean-To-Market Age Categories, Yiqun Jiang, Qing Li, Giovani Trevisan, Daniel C. L. Linhares, Cameron A. MacKenzie 2021 Iowa State University

Investigating The Relationship Of Porcine Reproductive And Respiratory Syndrome Virus Rna Detection Between Adult/Sow Farm And Wean-To-Market Age Categories, Yiqun Jiang, Qing Li, Giovani Trevisan, Daniel C. L. Linhares, Cameron A. Mackenzie

Veterinary Diagnostic and Production Animal Medicine Publications

Porcine reproductive and respiratory syndrome (PRRS) is a disease caused by the PRRS virus (PRRSV) that has spread globally in the last 30 years and causes huge economic losses every year. This research aims to 1) investigate the relationship between the PRRSV detection in two age categories (wean-to-market and adult/sow farm), and 2) examine the extent to which the wean-to-market PRRSV positive rate forecasts the adult/sow farm PRRSV positive rate. The data we used are the PRRSV RNA detection results between 2007 and 2019 integrated by the US Swine Disease Reporting System project that represent 95% of all ...


Covid-19: A One Health Issue, Karen Gruszynski 2021 Lincoln Memorial University

Covid-19: A One Health Issue, Karen Gruszynski

Cumberland Mountain Naturalist

COVID-19 has very rapidly become part of modern societal lexicon as the disease highlights the importance understanding zoonotic diseases and the impact they can have on human life. With a 177million human cases and 3.82million deaths globally at the time of this publication, the "One Health" nature of the disease has had a lasting impact across the planet. As the disease spread rapidly, it highlighted the dissemination of information through social media and other sources. With this in mind, Dr. Gary Vroegindewey, Director for One Health at LMU-CVM, put forth the idea to have students collect and summarize information ...


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