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10,259 full-text articles. Page 1 of 149.

Purification And Characterization Of A Fish Granzymea Involved In Cell-Mediated Immunity, Yuta Matsuura, Takeshi Yabu, Hajime Shiba, Teruyuki Nakanishi 2016 Nihon University

Purification And Characterization Of A Fish Granzymea Involved In Cell-Mediated Immunity, Yuta Matsuura, Takeshi Yabu, Hajime Shiba, Teruyuki Nakanishi

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Antigen Uptake In Zebrafish (Danio Rerio) At Different Life Stages, Louise von G Jørgensen 2016 The University of Maine

Antigen Uptake In Zebrafish (Danio Rerio) At Different Life Stages, Louise Von G Jørgensen

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Characterization And Functional Analysis Of Interleukin-12 In Amberjack Seriola Dumarili, Megumi Matsumoto Miss, Kyosuke Araki Dr, Kazuma Hayashi Mr, Hiroaki Suetake Dr, Atsushi Yamamoto Dr 2016 Faculty of Fisheries, Kagoshima University, Japan

Characterization And Functional Analysis Of Interleukin-12 In Amberjack Seriola Dumarili, Megumi Matsumoto Miss, Kyosuke Araki Dr, Kazuma Hayashi Mr, Hiroaki Suetake Dr, Atsushi Yamamoto Dr

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Induction Of Cell-Mediated Immune Responses After Vaccination With Inactivated Oil-Emulsion Nocardia Seriolae In Amberjack Seriola Dumerili, Kyosuke Araki, Megumi Matsumoto, Kazuma Hayashi, Atsushi Yamamoto 2016 Faculty of Fisheries, Kagoshima University, Japan

Induction Of Cell-Mediated Immune Responses After Vaccination With Inactivated Oil-Emulsion Nocardia Seriolae In Amberjack Seriola Dumerili, Kyosuke Araki, Megumi Matsumoto, Kazuma Hayashi, Atsushi Yamamoto

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Animal Carcinogenicity Studies: 1. Poor Human Predictivity, Andrew Knight, Jarrod Bailey, Jonathan Balcombe 2016 Animal Consultants International

Animal Carcinogenicity Studies: 1. Poor Human Predictivity, Andrew Knight, Jarrod Bailey, Jonathan Balcombe

Andrew Knight, Ph.D.

The regulation of human exposure to potentially carcinogenic chemicals constitutes society’s most important use of animal carcinogenicity data. Environmental contaminants of greatest concern within the USA are listed in the Environmental Protection Agency’s (EPA’s) Integrated Risk Information System (IRIS) chemicals database. However, of the 160 IRIS chemicals lacking even limited human exposure data but possessing animal data that had received a human carcinogenicity assessment by 1 January 2004, we found that in most cases (58.1%; 93/160), the EPA considered animal carcinogenicity data inadequate to support a classification of probable human carcinogen or non-carcinogen. For the ...


The Relationship Between Canine Nasal Length And Second-Hand Smoke Cotinine Levels, Sierra Wilson, Terry Derting 2016 Murray State University

The Relationship Between Canine Nasal Length And Second-Hand Smoke Cotinine Levels, Sierra Wilson, Terry Derting

Scholars Week

Second-hand smoke (SHS) has been associated with respiratory cancers in canines, with the predisposed locations determined by the cephalic ratio (head length / head width). Exposure to SHS is frequently measured by analyzing urine or blood samples for the nicotine by-product cotinine. We investigated the suitability of saliva as an alternative source for cotinine analyses in dogs because obtaining saliva is less invasive and cotinine concentrations from SHS exposure are instantaneously measurable in saliva compared to other collection methods. Specifically, we tested for a quantitative relationship between cephalic ratio and the salivary concentration of cotinine. Our null hypothesis was that there ...


Animal-Assisted Therapy For Military Veterans With Posttraumatic Stress Disorder: An Investigation On The Positive Effects Of Attachment And Affiliation Behaviors, Sara Miele 2016 Dominican University of California

Animal-Assisted Therapy For Military Veterans With Posttraumatic Stress Disorder: An Investigation On The Positive Effects Of Attachment And Affiliation Behaviors, Sara Miele

Scholarly and Creative Works Conference

Posttraumatic stress disorder (PTSD) develops in people who have experienced a traumatic event (nimh.nih.gov, 2016). Because PTSD is a chronic disorder, it is associated with impaired quality of life (Stern et al., 2013). A specific population at high risk for developing PTSD is military veterans. It is estimated over half a million military veterans suffer from PTSD (Stern et al., 2013). Although there are psychological services and treatments for veterans, many do not seek help because fear of the negative stigma associated with mental illness (Lanning & Krenek, 2013). Recently, efforts have been made to implement veteran friendly treatment ...


Conversations With Veterinary Students: Attitudes, Ethics, And Animals, Harold A. Herzog, Tamara L. Vore, John C. New Jr. 2016 Western Carolina University

Conversations With Veterinary Students: Attitudes, Ethics, And Animals, Harold A. Herzog, Tamara L. Vore, John C. New Jr.

Harold Herzog

Interviews were conducted with 24 graduating veterinary students to examine (a) changes in their attitudes toward animals; (b) the types of experiences and procedures that they found personally distressing; (c) their perceptions of the most important ethical issues that they will face in private practice; and (d) their responses to euthanizing animals. Students’ responses differed considerably. For example, about half of the students claimed that they were not affected by euthanasia, but another 25% still were struggling with this aspect of their professional role. Rationalization was a common mechanism by which the students attempted to deal with stressful experiences. It ...


Development Of An In Vivo Rnai Protocol To Investigate Gene Function In The Filarial Nematode, Brugia Malayi, Chuanzhe Song, Jack Gallup, Timothy Day, Lyric Bartholomay, Michael Kimber 2016 Iowa State University

Development Of An In Vivo Rnai Protocol To Investigate Gene Function In The Filarial Nematode, Brugia Malayi, Chuanzhe Song, Jack Gallup, Timothy Day, Lyric Bartholomay, Michael Kimber

Michael Kimber

Our ability to control diseases caused by parasitic nematodes is constrained by a limited portfolio of effective drugs and a paucity of robust tools to investigate parasitic nematode biology. RNA interference (RNAi) is a reverse-genetics tool with great potential to identify novel drug targets and interrogate parasite gene function, but present RNAi protocols for parasitic nematodes, which remove the parasite from the host and execute RNAi in vitro, are unreliable and inconsistent. We have established an alternative in vivo RNAi protocol targeting the filarial nematode Brugia malayi as it develops in an intermediate host, the mosquito Aedes aegypti. Injection of ...


Thymus Transcriptome Response To Avian Pathogenic E. Coli (Apec) Infection, Hongyan Sun, Peng Liu, Lisa Nolan, Susan Lamont 2016 Iowa State University

Thymus Transcriptome Response To Avian Pathogenic E. Coli (Apec) Infection, Hongyan Sun, Peng Liu, Lisa Nolan, Susan Lamont

Lisa K. Nolan

Colibacillosis, caused by avian pathogenic Escherichia coli (APEC), is responsible for multi-million dollar losses in the poultry industry every year in the United States. Therefore, it is important to understand the functional genomics of avian response to APEC, to find effective control strategies. The transcriptome characterizes genetic elements that are expressed. The thymus transcriptomes of 24 birds with known challenge status, necropsy day, and pathology level were sequenced using RNA-Seq. Many innate immune response pathways were significantly changed. Differentially expressed (DE) genes analysis showed APEC infection affected immune homeostasis through impairing the engagement of regulatory signal transduction pathways for T ...


Variation In Avian Pathogenic Escherichia Coli Colonization Levels In Chickens, Melissa Monson, Michael Kaiser, Susan Lamont 2016 Iowa State University

Variation In Avian Pathogenic Escherichia Coli Colonization Levels In Chickens, Melissa Monson, Michael Kaiser, Susan Lamont

Melissa Monson

Colonization levels in five tissues after avian pathogenic Escherichia coli (APEC) inoculation were investigated in chickens to generate phenotypic data for a genome wide association study (GWAS). Bacterial loads were measured in 370 birds and varied among individuals and tissues. Mean bacterial levels were significantly different between tissues (right lung > spleen > left lung and liver > blood). There were also significant correlations in bacterial load between tissues. These data suggest that colonization levels could be used as phenotypes in GWAS and could help identify markers associated with poultry resistance to APEC infections. After verification, these markers could be used for genetic ...


Association Of Different Iowa Livestock Truck Wash Stations Service Levels With Enterobacteriaceae Counts, Amber Danielson, Samaneh Azarpajouh, Anna Johnson, James Dickson, Locke Karriker, Rodney Baker, Christopher Rademacher, Troy Bigelow, Kenneth Stalder 2016 Iowa State University

Association Of Different Iowa Livestock Truck Wash Stations Service Levels With Enterobacteriaceae Counts, Amber Danielson, Samaneh Azarpajouh, Anna Johnson, James Dickson, Locke Karriker, Rodney Baker, Christopher Rademacher, Troy Bigelow, Kenneth Stalder

Samaneh Azarpajouh

Data from eighteen different truck washes were used to compare the association of different service levels with Enterobacteriaceae counts. Service levels were classified into three different categories; prewash (n=78), post wash with disinfectant (n=78), and post wash without disinfectant (n=12). A total of 168 drag swabs were used for collection for the purpose of this study. Prewash services were defined as trailers before they were scraped out and washed. Post wash with or without disinfectant services were defined as after the trailers were washed and disinfectant was or was not applied. Prewash trailers tended to have higher ...


Assessing U.S. Food Wastage And Opportunities For Reduction, Zhengxia Dou, James D. Ferguson, David T. Galligan, Alan M. Kelly, Steven M. Finn, Robert Giegengack 2016 University of Pennsylvania

Assessing U.S. Food Wastage And Opportunities For Reduction, Zhengxia Dou, James D. Ferguson, David T. Galligan, Alan M. Kelly, Steven M. Finn, Robert Giegengack

Departmental Papers (Vet)

Reducing food wastage is one of the key strategies to combat hunger and sustainably feed the world. We present a comprehensive analysis of available data, despite uncertainties due to data limitation, indicating that the U.S. loses at least 150 million metric tonnes (MMT) of food between farm and fork annually, of which about 70 MMT is edible food loss. Currently, <2% of the edible food loss is recovered for human consumption. A reasonably-attainable goal of food waste reduction at the source by 20% would save more food than the annual increase in total food production and would feed millions of people. This is an opportunity of significant magnitude, offering food security and resource and environmental benefits with few negatives. Seizing this opportunity requires technological innovation, policy intervention, and public outreach. This U.S.-based analysis is pertinent to other mid- to high-income countries.


Window Into Retinal Studies, Gustavo Aguirre 2016 University of Pennsylvania

Window Into Retinal Studies, Gustavo Aguirre

Gustavo D. Aguirre, VMD, PhD

Professor Gustavo Aguirre discusses the context of his research studies at the University of Pennsylvania, which are currently concentrating on the degenerative disease, retinitis pigmentosa.


Raav2/5 Gene-Targeting To Rods: Dose-Dependent Efficiency And Complications Associated With Different Promoters, William Beltran, Sanford Boye, Shannon Boye, Vince Chiodo, Alfred Lewin, William Hauswirth, Gustavo Aguirre 2016 University of Pennsylvania

Raav2/5 Gene-Targeting To Rods: Dose-Dependent Efficiency And Complications Associated With Different Promoters, William Beltran, Sanford Boye, Shannon Boye, Vince Chiodo, Alfred Lewin, William Hauswirth, Gustavo Aguirre

Gustavo D. Aguirre, VMD, PhD

A prerequisite for using corrective gene therapy to treat humans with inherited retinal degenerative diseases that primarily affect rods is to develop viral vectors that target specifically this population of photoreceptors. The delivery of a viral vector with photoreceptor tropism coupled with a rod-specific promoter is likely to be the safest and most efficient approach to target expression of the therapeutic gene to rods. Three promoters that included a fragment of the proximal mouse opsin promoter (mOP), the human G-protein-coupled receptor protein kinase 1 promoter (hGRK1), or the cytomegalovirus immediate early enhancer combined with the chicken β actin proximal promoter ...


Viral-Antibody Complexes In Canine Adenovirus Type I (Cav-1) Ocular Lesion: Leukocyte Chemotaxis And Enzyme Release, Leland Carmichael, B. Medic, Stephen Bistner, Gustavo Aguirre 2016 University of Pennsylvania

Viral-Antibody Complexes In Canine Adenovirus Type I (Cav-1) Ocular Lesion: Leukocyte Chemotaxis And Enzyme Release, Leland Carmichael, B. Medic, Stephen Bistner, Gustavo Aguirre

Gustavo D. Aguirre, VMD, PhD

Canine adenovirus-type 1 (CAV-1)-antibody complexes caused severe anterior uveitis with corneal edema ("blue eye") when injected into the anterior chamber of normal dogs. The response of the anterior uvea to such immune complexes (IC) was similar to the spontaneously occurring disease. In the presence of complement (C'), IC caused release of neutrophile chemotactic factors. Following phagocytosis of IC-C', leukocytes released lysosomal enzymes, as indicated by the presence of acid phosphatase in the surrounding medium. Membrane bound viral aggregates, presumably IC, were common in neutrophiles and in macrophages that had infiltrated the anterior chamber of opaque eyes that occurred after ...


Genetic And Phenotypic Variations Of Inherited Retinal Diseases In Dogs: The Power Of Within- And Across-Breed Studies, Keiko Miyadera, Gregory Acland, Gustavo Aguirre 2016 University of Pennsylvania

Genetic And Phenotypic Variations Of Inherited Retinal Diseases In Dogs: The Power Of Within- And Across-Breed Studies, Keiko Miyadera, Gregory Acland, Gustavo Aguirre

Gustavo D. Aguirre, VMD, PhD

Considerable clinical and molecular variations have been known in retinal blinding diseases in man and also in dogs. Different forms of retinal diseases occur in specific breed(s) caused by mutations segregating within each isolated breeding population. While molecular studies to find genes and mutations underlying retinal diseases in dogs have benefited largely from the phenotypic and genetic uniformity within a breed, within- and across-breed variations have often played a key role in elucidating the molecular basis. The increasing knowledge of phenotypic, allelic, and genetic heterogeneities in canine retinal degeneration has shown that the overall picture is rather more complicated ...


Exploring Human/Animal Intersections: Converging Lines Of Evidence In Comparative Models Of Aging, John Trojanowski, Joan Hendricks, Kathryn Jedrziewski, F. Brad Johnson, Kathryn Michel, Rebecka Hess, Michael Cancro, Margaret Sleeper, Robert Pignolo, Karen Teff, Gustavo Aguirre, Virginia Man-Yee Lee, Dennis Lawler, Allan Pack, Peter Davies 2016 University of Pennsylvania

Exploring Human/Animal Intersections: Converging Lines Of Evidence In Comparative Models Of Aging, John Trojanowski, Joan Hendricks, Kathryn Jedrziewski, F. Brad Johnson, Kathryn Michel, Rebecka Hess, Michael Cancro, Margaret Sleeper, Robert Pignolo, Karen Teff, Gustavo Aguirre, Virginia Man-Yee Lee, Dennis Lawler, Allan Pack, Peter Davies

Gustavo D. Aguirre, VMD, PhD

At a symposium convened on March 8, 2007 by the Institute on Aging at the University of Pennsylvania, researchers from the University’s Schools of Medicine and Veterinary Medicine explored the convergence of aging research emerging from the two schools. Studies in human patients, animal models, and companion animals have revealed different but complementary aspects of the aging process, ranging from fundamental biologic aspects of aging to the treatment of age-related diseases, both experimentally and in clinical practice. Participants concluded that neither animal nor human research alone will provide answers to most questions about the aging process. Instead, an optimal ...


Electroretinography In Veterinary Ophthalmology, Gustavo Aguirre 2016 University of Pennsylvania

Electroretinography In Veterinary Ophthalmology, Gustavo Aguirre

Gustavo D. Aguirre, VMD, PhD

No abstract provided.


The Pathology Of The Feline Model Of Mucopolysaccharidosis Vi, Mark Haskins, Gustavo Aguirre, Peter Jezyk, Donald Patterson 2016 University of Pennsylvania

The Pathology Of The Feline Model Of Mucopolysaccharidosis Vi, Mark Haskins, Gustavo Aguirre, Peter Jezyk, Donald Patterson

Gustavo D. Aguirre, VMD, PhD

Three cats with feline arylsulfatase-B-deficient mucopolysaccharidosis were studied by light and transmission electron microscopy. Membrane-bound cytoplasmic inclusions were present in hepatocytes, bone marrow granulocytes, vascular smooth muscle cells, and fibroblasts in skin, cornea, and cardiac valves. Central nervous system lesions were restricted to mild ventricular dilatation, perithelial cell vacuolation, and, in one animal, cord compression by vertebral exostoses. The lesions in these cats closely resembled those described in human patients with mucopolysaccharidosis VI (Maroteaux-Lamy syndrome).


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