Atypical Presentation Of Obstructed Hemivagina And Ipsilateral Renal Anomaly, 2018 George Washington University
Atypical Presentation Of Obstructed Hemivagina And Ipsilateral Renal Anomaly, Christopher Grant, Christopher E. Bayne, N. Kern, Craig A. Peters
Urology Faculty Publications
Herlyn-Werner-Wunderlich Syndrome, otherwise known as obstructed hemivagina and ipsilateral renal anomaly (OHVIRA), is a rare Müllerian anomalyconsisting of uterine didelphys, hemivaginal septum, and ipsilateral renal agenesis. Patients often present at the onset of menarche with abdominal pain and a pelvic mass from an obstructed hemivagina. We report a child who presented with a febrile urinary tract infection and upon further workup was found to have OHVIRA.
Transcriptome Analysis Of Neisseria Gonorrhoeae During Natural Infection Reveals Differential Expression Of Antibiotic Resistance Determinants Between Men And Women, Kathleen Nudel, Ryan Mcclure, Matthew Moreau, Emma Briars, A. Jeanine Abrams, Brian Tjaden, Xiao-Hong Su, David Trees, Peter A. Rice, Paola Massari, Caroline A. Genco
Open Access Articles
Neisseria gonorrhoeae is a bacterial pathogen responsible for the sexually transmitted infection gonorrhea. Emergence of antimicrobial resistance (AMR) of N. gonorrhoeae worldwide has resulted in limited therapeutic choices for this infection. Men who seek treatment often have symptomatic urethritis; in contrast, gonococcal cervicitis in women is usually minimally symptomatic, but may progress to pelvic inflammatory disease. Previously, we reported the first analysis of gonococcal transcriptome expression determined in secretions from women with cervical infection. Here, we defined gonococcal global transcriptional responses in urethral specimens from men with symptomatic urethritis and compared these with transcriptional responses in specimens obtained from women ...
Trends And Determinants Of Stillbirth In Developing Countries: Results From The Global Network’S Population-Based Birth Registry, Sarah Saleem, Shiyam Sunder Tikmani, Elizabeth M. Mcclure, Janet L. Moore, Iqbal Azam Syed, Sangappa M. Dhaded, Shivaprasad S. Goudar, Ana Garces, Sumera Aziz Ali, Farnaz Naqvi
Community Health Sciences
Background: Stillbirth rates remain high, especially in low and middle-income countries, where rates are 25 per 1000, ten-fold higher than in high-income countries. The United Nations' Every Newborn Action Plan has set a goal of 12 stillbirths per 1000 births by 2030 for all countries.
Methods: From a population-based pregnancy outcome registry, including data from 2010 to 2016 from two sites each in Africa (Zambia and Kenya) and India (Nagpur and Belagavi), as well as sites in Pakistan and Guatemala, we evaluated the stillbirth rates and rates of annual decline as well as risk factors for 427,111 ...
Improving Pregnancy Outcomes In Low- And Middle-Income Countries, 2018 Columbia University, New York, NY, USA.
Improving Pregnancy Outcomes In Low- And Middle-Income Countries, Robert L. Goldenberg, Elizabeth M. Mcclure, Sarah Saleem
Community Health Sciences
This paper reviews the very large discrepancies in pregnancy outcomes between high, low and middle-income countries and then presents the medical causes of maternal mortality, stillbirth and neonatal mortality in low-and middle-income countries. Next, we explore the medical interventions that were associated with the very rapid and very large declines in maternal, fetal and neonatal mortality rates in the last eight decades in high-income countries. The medical interventions likely to achieve similar declines in pregnancy-related mortality in low-income countries are considered. Finally, the quality of providers and the data to be collected necessary to achieve these reductions are discussed. It ...
Stress Urinary Incontinence In Collegiate Female Athletes: Prevalence And Impact, 2018 The University of San Francisco
Stress Urinary Incontinence In Collegiate Female Athletes: Prevalence And Impact, Marie Bouchard
Master's Projects and Capstones
Introduction, definition: Urinary incontinence is the involuntary leaking of urine (a few drops to a few milliliters). It can happen while exercising with no urge to urinate (stress urinary incontinence), with a sudden urge to urinate (overactive bladder or urgency urinary incontinence), or a combination of the two (mixed urinary incontinence). This issue is very common among female athletes. However, because of the reluctance to discuss this problem, it remains underdiagnosed and undertreated.
Methods:An anonymous and confidential survey was distributed to the 90 University of San Francisco female student athletes from seven different varsity sports in December 2017 ...
Barriers To Pregnancy Spacing In Women Living With Hiv: A Series Of Informational Interviews, 2018 MedStar Health Research Institute and Department of Women’s and Infants’ Services, MedStar Washington Hospital Center
Barriers To Pregnancy Spacing In Women Living With Hiv: A Series Of Informational Interviews, Rachel K. Scott, Piyapa Praditpan, Patricia Tanjutco, Elizabeth Laidlaw, Regina Zopf, Manon M. Schladen
The Qualitative Report
For reproductive-age women living with HIV, birth spacing allows for optimization of maternal health and viral suppression to prevent mother-to-child transmission of HIV. We conducted semi-structured informational interviews to explore use of contraception for birth spacing. Interviews were transcribed and analyzed. Audio files were reviewed to capture non-explicit data. We interviewed 18 multiparous HIV positive women. All described experiences with at least one contraceptive method. Six themes emerged: Burden of contraception, Failure of birth control, Impact of youth and lack of life experience, Community beliefs about birth control, Lack of partner cooperation, and Altruism. Women viewed birth spacing favorably. Young ...
A Rare But Life Threatening Case Of Labile Blood Pressures In Pregnancy, 2018 Rowan University SOM
A Rare But Life Threatening Case Of Labile Blood Pressures In Pregnancy, Kelsey Carrio Md, Aarti Aggarwal Md, Susan Mcgroarty Phd
Stratford Campus Research Day
Pheochromocytoma is a rare but life threatening adrenal secreting tumor. The infrequency with which it is encountered makes pheochromocytoma, especially in pregnancy, a formidable diagnostic challenge.
Although a pheochromocytoma is rare, it is good to keep it in differential diagnosis as a possible cause of labile BP with headaches and significant orthostatic BP. It is critical to recognize this condition to institute an appropriate therapy & surgical intervention to prevent mortality.
High Maternal Dietary Glycemic Index And Sugar Consumption And Their Association With Birth Defects And Pregnancy Complications, Nicole Thornton
Carroll College Student Undergraduate Research Festival
Objective: The purpose of this systematic review was to look at existing peer reviewed articles regarding high maternal dietary glycemic index (DGI) and/or sugar consumption (including glucose, fructose, and sucrose) and the risk for birth defects or pregnancy complications.
Methods: PubMed was the primary database used to search for relevant articles. Other related articles were found in the reference sections of the articles screened in the original search.
Results: Nine case-control and cohort studies were used in this review. Five of the six case-control studies found a significant risk between high maternal DGI and/or sugar intake and birth ...
The Youngest Victims Of The Opioid Epidemic, 2018 Cedarville University
The Youngest Victims Of The Opioid Epidemic, Katelyn E. Miller, Abby Reed
The Research and Scholarship Symposium
When babies are born to opioid-addicted mothers, they often develop Neonatal Abstinence Syndrome (NAS). NAS is characterized by symptoms associated with abrupt opioid withdrawal (“Neonatal Abstinence”, 2015). By preventing NAS in babies before they are born and properly caring for a baby with NAS after birth, we will aim to decrease the incidence of this condition and as its harmful effects in the lives of babies. In Ohio, there are many neonates suffering from NAS. The rates for babies born with NAS have quadrupled since 2011 when 2.2 out of every 1000 babies had NAS to 2015, where 12 ...
Cross Talk Between Serum Kisspeptin-Leptin During Assisted Reproduction Techniques, 2018 Aga Khan University
Cross Talk Between Serum Kisspeptin-Leptin During Assisted Reproduction Techniques, Rehana Rehman, Zehra Jamil, Aqsa Khalid, Syeda Sadia Fatima
Department of Biological & Biomedical Sciences
Background & Objective: Leptin facilitates onset of puberty by impact on hypothalamic Kisspeptin, gonadotropin releasing hormone, follicle stimulating and luteinizing hormone. The link of peripheral Leptin-Kisspeptin in regulating the ovarian and endometrial tissue in relation to adiposity is unknown. Therefore, we wanted to identify Kisspeptin-Leptin association with body mass index (BMI) and success of assisted reproductive treatments (ART) in infertile females.
Methods: A cross sectional study was carried from August 2014 till May 2016 after receiving ethical approval at Australian Concept Infertility Medical Centre, and Aga Khan University. The study group comprised of females with an age range of 25-37 year who had duration of unexplained infertility for more than two years. They were grouped as; underweight (/m2), normal weight (18-22.9 kg/m2), overweight 23-24.99 kg/m2 and obese (>25 kg/m2). Kisspeptin and Leptin levels were measured by enzyme linked immune sorbent assay before down regulation of ovaries and initiation of treatment protocol of ART. Failure of procedure was detected by beta human chorionic gonadotropin <25mIU/ml (non-pregnant) whereas females with levels >25mIU/ml and cardiac activity on trans-vaginal scan were declared pregnant.
Results: Highest Kisspeptin and Leptin levels were seen in normal weight group (374.80 ± 185.08ng/L; 12.78 ± 6.8 pg/ml) respectively, yet the highest number of clinical ...25miu/ml>
Evaluation Of The Accessibility Of Structured Exercise Programs For Pregnant Women: An Analysis Of Offerings At The Ymcas Of Massachusetts, Janelle Driscoll, Vidya Iyer, Ashley Medeiros, Shobhana Parameshwaran, Alissa Dangel
Community Engagement and Research Symposia
The American Congress of Obstetrics and Gynecology recommends that exercise should be encouraged in women with uncomplicated pregnancies. Potential benefits of exercise include a decreased incidence of medical complications of pregnancy, including gestational diabetes and preterm labor. Additional benefits include decreased incidence of excessive maternal weight gain, cesarean sections and low birthweight of the newborn. The Massachusetts' rate of gestational diabetes was 4.7% in 2015 with 7.8% babies being born at low birth weight and 8.6% born preterm statewide. The aim of this project was to evaluate the availability of structured exercise programs tailored specifically to pregnant ...
Creating The Capacity To Screen Deaf Women For Perinatal Depression, 2018 University of Massachusetts Medical School
Creating The Capacity To Screen Deaf Women For Perinatal Depression, Kelly S. Wolf Craig, Melissa L. Anderson, Kathleen Biebel, Nancy Byatt
Community Engagement and Research Symposia
There are approximately 1 million Deaf women in the U.S. who depend on American Sign Language (ASL) for communication. Although Deaf women become pregnant and enter motherhood at rates similar to hearing women, Deaf women attend fewer prenatal appointments, receive less information from their physicians, are less satisfied with physician concern and quality of communication, and are less satisfied with their prenatal care. These barriers persist after childbirth, leaving Deaf mothers with little professional support for struggles with postnatal healthcare, breastfeeding, and childcare.
Combined with pre-existing mental health disparities observed among members of the Deaf community, such barriers leave ...
A Common Pain In Pregnancy With An Uncommon Cause, 2018 University of Massachusetts Medical School
A Common Pain In Pregnancy With An Uncommon Cause, Jennifer Baima, Amrit V. Vinod, Mathew J. Most
Orthopedics and Physical Rehabilitation Publications and Presentations
Case Diagnosis: We present a case of a patient with hip pain during pregnancy determined to be pigmented villonodular synovitis (PVNS).
Case Description: A 41-year-old woman presented with 9-months of persistent atraumatic left hip pain localized to the groin that had started in her second trimester of pregnancy. Five months after delivery at presentation to clinic, her symptoms had progressively worsened to require a cane for ambulation.
On exam, hip range of motion was limited: flexion to 90o, external rotation to 20o, and internal rotation to 10o. She had groin pain with internal and external rotation. She ...
The Effects Of Continuous Insulin Pump Therapy On Glycemic Control In Pregnant Type 1 Diabetics, 2017 Dominican University of California
The Effects Of Continuous Insulin Pump Therapy On Glycemic Control In Pregnant Type 1 Diabetics, Kimberly Kelsey
Senior Theses and Capstone Projects
Type 1 Diabetics have various ways of managing their diabetes that have been studied for their effectiveness. Pregnancy in the Type 1 Diabetic has been understudied. It is known that Diabetics in general have poorer pregnancy outcomes because of poor glycemic control. This coupled with the fact that the body needs 3-4 times more insulin as pregnancy comes to an end makes managing blood glucose levels challenging for diabetics (Lowdermilk, 2016, p. 689). For the Type 1 Diabetic, there are two main ways to control diabetes: multiple daily injections using at least two type of insulin and continuous subcutaneous insulin ...
Vaginal Cuff Dehiscence Presenting With Free Air 60 Days After Robotic-Assisted Hysterectomy, 2017 University of Massachusetts Medical School
Vaginal Cuff Dehiscence Presenting With Free Air 60 Days After Robotic-Assisted Hysterectomy, Daniel Munger, M. Iannamorelli, C. Galvez, C. Service
Open Access Articles
Introduction: The vast majority of patients presenting with pneumoperitoneum have visceral organ perforation and require urgent diagnostic laparoscopy. Nonsurgical causes are relatively rare and may be attributed to multiple etiologies.
Case Presentation: Here we describe the case of a 38-year-old Caucasian female who presented to the emergency department with three days of cramping, epigastric abdominal pain. Her physical exam was notable for tenderness to palpation in the epigastric area and abdominal and chest X-rays showed free air under the diaphragm. Free air around the porta hepatis was verified on CT scan. Approximately 90% of pneumoperitoneum cases are due to perforation ...
Risk Of Preeclampsia After Gestational Exposure To Selective Serotonin Reuptake Inhibitors And Other Antidepressants: A Study From The Norwegian Mother And Child Cohort Study, Angela Lupattelli, Mollie Wood, Kate L. Lapane, Olav Spigset, Hedvig Nordeng
Open Access Articles
PURPOSE: To describe the risk of early- and late-onset preeclampsia across pregnancies exposed to antidepressants and to evaluate the impact of timing and length of gestational exposure to antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), on preeclampsia.
METHODS: The Norwegian Mother and Child Cohort, a prospective population-based study, and the Medical Birth Registry of Norway provided information on antidepressant exposure, depression, and anxiety symptoms in pregnancy, preeclampsia diagnoses, and important covariates. Within a pregnancy cohort of depressed women, we compared the risk of late-onset preeclampsia between SSRI-exposed and nonmedicated pregnancies using marginal structural models (weighted) and modified Poisson regression models ...
Flt1 And Transcriptome-Wide Polyadenylation Site (Pas) Analysis In Preeclampsia, 2017 University of Massachusetts Medical School
Flt1 And Transcriptome-Wide Polyadenylation Site (Pas) Analysis In Preeclampsia, Ami Ashar-Patel, Yasin Kaymaz, Augustine Rajakumar, Jeffrey A. Bailey, S. Ananth Karumanchi, Melissa J. Moore
Open Access Articles
Maternal symptoms of preeclampsia (PE) are primarily driven by excess anti-angiogenic factors originating from the placenta. Chief among these are soluble Flt1 proteins (sFlt1s) produced from alternatively polyadenylated mRNA isoforms. Here we used polyadenylation site sequencing (PAS-Seq) of RNA from normal and PE human placentae to interrogate transcriptome-wide gene expression and alternative polyadenylation signatures associated with early-onset PE (EO-PE; symptom onset < 34 weeks) and late-onset PE (LO-PE; symptom onset > 34 weeks) cohorts. While we observed no general shift in alternative polyadenylation associated with PE, the EO-PE and LO-PE cohorts do exhibit gene expression profiles distinct from both each other and from normal placentae. The only two genes upregulated ...
Maternal And Fetal Complications Of Antiphospholipid Syndrome: A Case Report With Long-Term Follow-Up, 2017 Aga Khan University
Maternal And Fetal Complications Of Antiphospholipid Syndrome: A Case Report With Long-Term Follow-Up, Tahira Naru, Mohammad Khurshid, Zafar Nazir
We report a case of a 26- year old woman having antiphospholipid syndrome in pregnancy with long-term follow up. She presented with recurrent miscarriages, venous thrombosis, avascular necrosis of femoral head, mid-cerebral artery infarction and skin ulcers. Antiphospholipid syndrome is a recognized disorder of pregnancy. Diagnosis requires a high index of suspicion when evaluating women with recurrent pregnancy losses and vascular thrombosis. A low dose aspirin combined with heparin can reduce morbidity and improves the pregnancy outcome.
Diagnosing Ectopic Pregnancy In The Emergency Setting, 2017 University of Massachusetts Medical School
Diagnosing Ectopic Pregnancy In The Emergency Setting, Robert Lee, Carolyn S. Dupuis, Byron Y. Chen, Andrew Smith, Young H. Kim
Radiology Publications and Presentations
Ectopic pregnancy is the implantation of a fertilized egg outside the uterine endometrial cavity. For women presenting to the emergency department with abdominal pain and/or vaginal bleeding, ectopic pregnancy is an important diagnostic consideration. The diagnosis is made based on laboratory values and ultrasound imaging findings. The ultrasound appearance of both normal early pregnancy and ectopic pregnancy are variable and often subtle, presenting diagnostic challenges for radiologists. This pictorial essay describes and illustrates the sonographic findings of ectopic pregnancy and reviews the differential diagnoses that can mimic ectopic pregnancy on ultrasound. With the possibility of medical management, the value ...
Hereditary Renal Amyloidosis Associated With A Novel Apolipoprotein A-Ii Variant, 2017 Boston University
Hereditary Renal Amyloidosis Associated With A Novel Apolipoprotein A-Ii Variant, Tatiana Prokaeva, Harun Akar, Brian Spencer, Andrea Havasi, Haili Cui, Carl J. O'Hara, Olga Gursky, John D. Leszyk, Martin Steffen, Sabrina Browning, Allison Rosenberg, Lawreen H. Connors
Open Access Articles
Here, we report a family with renal amyloidosis associated with a novel stop codon mutation in APOA2 and the apoA-II variant, 78Leuext21.