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Heart Rate Recovery Following Exercise Testing In Pediatric Patients With Acyanotic Repaired Congenital Heart Disease, Natalie S. Shwaish 2020 Children's Mercy Hospital

Heart Rate Recovery Following Exercise Testing In Pediatric Patients With Acyanotic Repaired Congenital Heart Disease, Natalie S. Shwaish

Research Days

No abstract provided.


Ethical Analysis Of Scandals In Congenital Heart Surgery Programs, Ian D. Wolfe 2020 Children's Mercy Kansas City

Ethical Analysis Of Scandals In Congenital Heart Surgery Programs, Ian D. Wolfe

Research Days

No abstract provided.


Isolated Polymorphic Ventricular Tachycardia: An Unusual Presentation Of Acute Myocarditis, Natalie S. Shwaish 2020 Children's Mercy Hospital

Isolated Polymorphic Ventricular Tachycardia: An Unusual Presentation Of Acute Myocarditis, Natalie S. Shwaish

Research Days

No abstract provided.


Angiopoietin 1 Protects Against Lps-Induced Acute Lung Injury And Alveolar Remodeling In Neonatal Mice, Umar Salimi 2020 Childrens Mercy Hospital

Angiopoietin 1 Protects Against Lps-Induced Acute Lung Injury And Alveolar Remodeling In Neonatal Mice, Umar Salimi

Research Days

No abstract provided.


The Role Of Central Ace2 And Nrf2 In Sympatho-Excitation: Responses To Central Angiotensin Ii, Anyun Ma 2020 University of Nebraska Medical Center

The Role Of Central Ace2 And Nrf2 In Sympatho-Excitation: Responses To Central Angiotensin Ii, Anyun Ma

Theses & Dissertations

Sympatho-excitation is a key characteristic in cardiovascular diseases such as chronic heart failure (CHF) and primary Hypertension (HTN). Evidence suggests that increased sympathetic tone is closely related to activation of the Renin-Angiotensin-Aldosterone system (RAAS) in the central nervous system. An underlying mechanism for sympatho-excitation is thought to be oxidative stress resulting from Angiotensin II (AngII) type 1 receptor (AT1R) activation. Over the past several decades, pharmacological targeting of components of the RAAS have been used as standard therapy in CHF and HTN. However, additional therapeutic strategies are necessary to control these diseases. Oxidative stress is regulated, in part, by the ...


The Evolving Management Of Aortic Valve Disease: Trends In The Utilization And Cost Of Savr, Tavr, And Medical Therapy, Andrew Goldsweig 2020 University of Nebraska Medical Center

The Evolving Management Of Aortic Valve Disease: Trends In The Utilization And Cost Of Savr, Tavr, And Medical Therapy, Andrew Goldsweig

Theses & Dissertations

Aortic stenosis (AS) and regurgitation (AR) may be treated with surgical aortic valve replacement (SAVR), transcatheter AVR (TAVR), or medical therapy (MT). Data are lacking regarding usage and cost of SAVR, TAVR, and MT for patients hospitalized with aortic valve disease. From the Nationwide Readmissions Database, we determined utilization and cost trends for SAVR, TAVR, and MT in patients with aortic valve disease admitted 2012-2016 for valve replacement, heart failure, unstable angina, non-ST-elevation myocardial infarction, or syncope. From 2012 through 2016, there was a 48.1% increase in the number of patients hospitalized for aortic valve disease annually. Overall, 19 ...


Association Of Childhood Psychosocial Environment With 30-Year Cardiovascular Disease Incidence And Mortality In Middle Age, Jacob B. Pierce, Kiarri N. Kershaw, Catarina I. Kiefe, David R. Jacobs Jr., Stephen Sidney, Sharon Stein. Merkin, Joe Feinglass 2020 Northwestern University

Association Of Childhood Psychosocial Environment With 30-Year Cardiovascular Disease Incidence And Mortality In Middle Age, Jacob B. Pierce, Kiarri N. Kershaw, Catarina I. Kiefe, David R. Jacobs Jr., Stephen Sidney, Sharon Stein. Merkin, Joe Feinglass

Open Access Articles

Background

Childhood adversity and trauma have been shown to be associated with poorer cardiovascular disease (CVD) outcomes in adulthood. However, longitudinal studies of this association are rare.

Methods and Results

Our study used the CARDIA (Coronary Artery Risk Development in Young Adults) Study, a longitudinal cohort that has followed participants from recruitment in 1985-1986 through 2018, to determine how childhood psychosocial environment relates to CVD incidence and all-cause mortality in middle age. Participants (n=3646) completed the Childhood Family Environment (CFE) questionnaire at the year 15 (2000-2001) CARDIA examination and were grouped by high, moderate, or low relative CFE adversity ...


Sleep Duration And The Effects On Cholesterol Levels In College Students., Jared Collier 2020 University of Arkansas, Fayetteville

Sleep Duration And The Effects On Cholesterol Levels In College Students., Jared Collier

Biological Sciences Undergraduate Honors Theses

Cardiovascular disease is a rising issue in the United States causing large death rates along with large medical expenses. College students are potentially at risk of CVD due to a lack of knowledge of their health, including cholesterol level. Sleep is an essential biological function which helps with the body’s repair, recovery, conservation of energy and maintains cardiovascular regulation. The purpose of this study was to see if there is a correlation between sleep duration and cholesterol levels in college students. Twenty-seven student participants were recruited from the Exercise is Medicine cohort . In-person assessments were conducted at the HPER ...


Progressive Collateral Stenosis Leading To Symptomatic Chronic Total Occlusion, Farhan Shah MD, Andrew Maiolo MD 2020 HCA Healthcare

Progressive Collateral Stenosis Leading To Symptomatic Chronic Total Occlusion, Farhan Shah Md, Andrew Maiolo Md

Capital Division Virtual Research Day 2020

Chronic total occlusion is defined as the complete obstruction of a coronary artery, with TIMI 0 or TIMI 1 flow, and an occlusion duration of greater than 3 months. We present a case of symptomatic chronic total occlusion in a functional 79 year old female with no past history of coronary artery disease, previously asymptomatic due to robust collateral circulation.


Impact Of Slco1b1 Genetic Variation On Rosuvastatin Systemic Exposure In Pediatric Hypercholesterolemia., Jonathan B. Wagner, Susan M. Abdel-Rahman, Andrea Gaedigk, R Gaedigk, Geetha Raghuveer, Vincent S. Staggs, Leon Van Haandel, J Steven Leeder 2020 Children's Mercy Hospital

Impact Of Slco1b1 Genetic Variation On Rosuvastatin Systemic Exposure In Pediatric Hypercholesterolemia., Jonathan B. Wagner, Susan M. Abdel-Rahman, Andrea Gaedigk, R Gaedigk, Geetha Raghuveer, Vincent S. Staggs, Leon Van Haandel, J Steven Leeder

Manuscripts, Articles, Book Chapters and Other Papers

This study investigated the impact of SLCO1B1 genotype on rosuvastatin systemic exposure in hypercholesterolemic children and adolescents. Participants (8-21 years) with at least one allelic variant of SLCO1B1 c.521T>C (521TC, n = 13; 521CC, n = 2) and wild type controls (521TT, n = 13) completed a single oral dose pharmacokinetic study. The variability contributed by SLCO1B1 c.521 sequence variation to rosuvastatin (RVA) systemic exposure among our pediatric cohort was comparable to previous studies in adults. RVA concentration-time curve from 0-24 hours (AUC


Primary Cilia-Mediated Ventricular Maturation In Congenital Heart Disease: A Role For Erbb Signaling?, Lindsey A. Fitzsimmons, Sergey Ryzhov, Kerry L. Tucker 2020 Maine Medical Center

Primary Cilia-Mediated Ventricular Maturation In Congenital Heart Disease: A Role For Erbb Signaling?, Lindsey A. Fitzsimmons, Sergey Ryzhov, Kerry L. Tucker

Costas T. Lambrew Research Retreat 2020

The embryonic heart requires a unique, and highly-specialized group of progenitor cells called the cardiac neural crest (CNCC), which are known to contribute specifically to the developing valves, the interventricular septum, and the great vessels of the outflow tract. CNCC display primary cilia, which are tiny, plasma-membrane bound organelles that function to modulate cell signaling mechanisms involved in normal heart development as well as congenital heart disease (CHD). Our laboratory has modeled CNCC-specific ciliary loss, using a Wnt1:Cre-2, Ift88-targeted conditional elimination of primary cilia. Loss of cilia in CNCC of Ift88-homozygous mutants (MUT) was characterized by a variety of ...


Chemokine Dynamics And The Inflammatory Response After Cardiac Injury, Joanne Taylor deKay, David B. Seder, Michael P. Robich, Douglas B. Sawyer, Teresa May, John Dziodzio, Ivette F. Emery, F.L. Lee Lucas, Angela Leclerc, Barbara McCrum, Christine Lord, Ashley Eldridge, Fumito Ichinose, Richard Riker, Sergey V. Ryzhov 2020 Maine Medical Center

Chemokine Dynamics And The Inflammatory Response After Cardiac Injury, Joanne Taylor Dekay, David B. Seder, Michael P. Robich, Douglas B. Sawyer, Teresa May, John Dziodzio, Ivette F. Emery, F.L. Lee Lucas, Angela Leclerc, Barbara Mccrum, Christine Lord, Ashley Eldridge, Fumito Ichinose, Richard Riker, Sergey V. Ryzhov

Costas T. Lambrew Research Retreat 2020

Problem/Background: The initial ischemic insult of a cardiac arrest (CA) episode triggers the inflammatory response, resulting in neurological, circulatory, and systemic ischemia-reperfusion injuries that are frequently fatal. More than 500,000 Americans suffer cardiac arrest annually, and despite improved cardiopulmonary resuscitation, post-resuscitation therapy, and cardiovascular systems of care, outcomes remain poor. Understanding molecular mechanisms contributing to survival after CA may lead to identification of therapeutic targets and improvement of outcomes. Chemotactic cytokines (chemokines) are secreted soluble or membrane-bound proteins that signal through G-protein coupled receptors to stimulate immune cell migration to the site of injury, acting as the first ...


Feasibility And Safety Of Uninterrupted And Nearly Uninterrupted Doac Use In Patients Undergoing Radiofrequency Ablation For Atrial Fibrillation In A Tertiary Community Medical Center, William Adam Janes, Wendy Craig, Kyle Cunningham, Jill Knutson, Amanda Haskell, Henry Sesselberg 2020 Maine Medical Center

Feasibility And Safety Of Uninterrupted And Nearly Uninterrupted Doac Use In Patients Undergoing Radiofrequency Ablation For Atrial Fibrillation In A Tertiary Community Medical Center, William Adam Janes, Wendy Craig, Kyle Cunningham, Jill Knutson, Amanda Haskell, Henry Sesselberg

Costas T. Lambrew Research Retreat 2020

Background: Atrial fibrillation (AF) ablation in the setting of uninterrupted anticoagulation (AC) has been studied by large university based medical centers in randomized controlled trials. This strategy has not been looked at in a clinical based Electrophysiology (EP) program at a tertiary hospital.

Methods: Patients aged 18 years or older who presented to Maine Medical Center and captured in the American Heart Association (AHA) Get With The Guidelines: Afib database between 1/1/2015 and 6/1/2019 were eligible. Inclusion criteria were any patient with a left side AF procedure (Pulmonary vein isolation [PVI] or other lesions). Patients were ...


Level Of Circulating Interleukin-21 After Cardiac Arrest, Andrew M. Muca, Joanne T. DeKay, Michael P. Robich, David B. Seder, Douglas B. Sawyer, Sergey Ryzhov 2020 Maine Medical Center

Level Of Circulating Interleukin-21 After Cardiac Arrest, Andrew M. Muca, Joanne T. Dekay, Michael P. Robich, David B. Seder, Douglas B. Sawyer, Sergey Ryzhov

Costas T. Lambrew Research Retreat 2020

Purpose/Background: Patients resuscitated from cardiac arrest (CA) have highly variable neurological, circulatory, and systemic ischemia-reperfusion injuries. The initial ischemic insult triggers immune and inflammatory responses, and results in a cascade of secondary injuries that are often fatal. Previous studies using animal’s model of cardiac arrest/cardiopulmonary resuscitation have demonstrated that interleukin-21 (IL-21) promotes brain injury through stimulation of lymphocytes accumulation. However, the role of IL-21 in neurological injury in humans has not been well characterized. The goal of this project was to determine the level of IL-21 in patients with cardiac arrest and resuscitation.

Methods/Approach: Post-cardiac arrest ...


Disparity In Physician Recognition Of Qt Interval Duration And Associated Mortality, Supraja Thunuguntla, Mohammed Rizwan, Mild Charles 2020 The University of Texas Rio Grande Valley

Disparity In Physician Recognition Of Qt Interval Duration And Associated Mortality, Supraja Thunuguntla, Mohammed Rizwan, Mild Charles

School of Medicine Publications and Presentations

Background

QT interval prolongation is associated with all-cause mortality (1,2). American Heart Association/American College of Cardiology (AHA/ACC) recommends considering QTc interval above 99th percentile as abnormally prolonged, to prevent Torsade de Pointes (TdP).

Methods

This is a retrospective chart review of 291 EKG’s (162 unique), from patients visiting our facility at Valley Baptist Medical Center (Harlingen) from January 2016 to March 2020. All EKG’s were read, the measured QT interval was corrected for heart rate using the Bazett formula. Simple descriptive statistics were created with all variables considered: patient age, gender, interpreting physician, report/ documentation ...


Effect Of Poverty Level On The Relationship Between Hyperlipidemia And Cardiorenal Syndrome, Sri K. Banerjee MD, PhD, Raymond Panas, James Diegel, Karen Banerjee 2020 Walden University, Core Faculty, Program Director Designee, College of Health Sciences

Effect Of Poverty Level On The Relationship Between Hyperlipidemia And Cardiorenal Syndrome, Sri K. Banerjee Md, Phd, Raymond Panas, James Diegel, Karen Banerjee

Journal of Health Disparities Research and Practice

Purpose. Elevated cholesterol is known to be associated with chronic kidney disease (CKD) and cardiovascular disease (CVD) independently. Cardiorenal syndrome (CRS), a recently defined syndrome, is characterized by renal failure that is closely interrelated to cardiac dysfunction. The effect of socioeconomic status on cardiorenal syndrome has not been explored in a multi-ethnic population. In this retrospective secondary analysis, the hypothesis was tested if socioeconomic status modifies the effect of hyperlipidemia on CRS.

Methods. The National Health and Nutrition Examination Survey (NHANES) is a cross sectional survey done on the non-institutionalized population of the United States. All patients from the NHANES ...


Investigating The Role Of Rap1a In Medial Arterial Vascular Calcification, Amelia Grace Haydel 2020 University of Mississippi

Investigating The Role Of Rap1a In Medial Arterial Vascular Calcification, Amelia Grace Haydel

Honors Theses

Cardiovascular disease is the leading cause of death in the United States with one of the major contributors being vascular calcification, characterized by the deposition of calcium-phosphate hydroxyapatite. Once thought to be a passive process due to aging, medial vascular calcification is becoming better understood as a tightly regulated, cellmediated process. Vascular smooth muscle cells (VSMCs) within the medial arterial layer respond to inflammation, oxidative stress, and changes in pyrophosphate levels, which induce differentiation into osteoblast-like cells. Fibroblasts within the adventitial layer (AFBs) also alter their function in response to vascular calcification signaling, although this is largely understudied. The AGE ...


Multimodal Photoplethysmography-Based Approaches For Improved Detection Of Hypertension, Kaylie Welykholowa, Richard Fletcher, Mohamed Elgendi 2020 University of British Columbia

Multimodal Photoplethysmography-Based Approaches For Improved Detection Of Hypertension, Kaylie Welykholowa, Richard Fletcher, Mohamed Elgendi

Open Access Articles

Elevated blood pressure (BP) is a major cause of death, yet hypertension commonly goes undetected. Owing to its nature, it is typically asymptomatic until later in its progression when the vessel or organ structure has already been compromised. Therefore, noninvasive and continuous BP measurement methods are needed to ensure appropriate diagnosis and early management before hypertension leads to irreversible complications. Photoplethysmography (PPG) is a noninvasive technology with waveform morphologies similar to that of arterial BP waveforms, therefore attracting interest regarding its usability in BP estimation. In recent years, wearable devices incorporating PPG sensors have been proposed to improve the early ...


Regenerative Medicine Therapy: Adipose Derived Extracellular Vesicles In Viral Myocarditis, David Gorelov, Damian N. Di Florio, Gary R. Salomon, Angita Jain, Nick E. Saikaili, Danielle J. Beetler, Swikriti Shrestha, Ming Tian, Joy Wolfram PhD, DeLisa Fairweather PhD 2020 University of North Florida

Regenerative Medicine Therapy: Adipose Derived Extracellular Vesicles In Viral Myocarditis, David Gorelov, Damian N. Di Florio, Gary R. Salomon, Angita Jain, Nick E. Saikaili, Danielle J. Beetler, Swikriti Shrestha, Ming Tian, Joy Wolfram Phd, Delisa Fairweather Phd

Showcase of Osprey Advancements in Research and Scholarship (SOARS)

Objective: Myocarditis, inflammation of the heart muscle, is an autoimmune heart disease that can be caused by viruses, bacteria and toxins. Myocarditis can lead to dilated cardiomyopathy (DCM) and heart failure. Currently there are no disease-specific therapies for treating myocarditis or preventing progression to DCM. Adipose Extracellular Vesicles (AEVs) are lipid bilayer nanoparticles that are released into the outside environment of adipocytes and provide promising regenerative potential for inflammatory diseases like myocarditis.

Methods: Lipoaspirate was obtained from women and men and AEVs isolated from the lipoaspirate using tangential flow filtration. We injected wild type male BALB/c mice with 250uL ...


The Association Between Patient-Reported Clinical Factors And 30-Day Acute Care Utilization In Chronic Heart Failure, Jinying Chen, Rajani S. Sadasivam, Amanda C. Blok, Christine S. Ritchie, Catherine S. Nagawa, Elizabeth Aaker Orvek, Kanan Patel, Thomas K. Houston 2020 University of Massachusetts Medical School

The Association Between Patient-Reported Clinical Factors And 30-Day Acute Care Utilization In Chronic Heart Failure, Jinying Chen, Rajani S. Sadasivam, Amanda C. Blok, Christine S. Ritchie, Catherine S. Nagawa, Elizabeth Aaker Orvek, Kanan Patel, Thomas K. Houston

Population and Quantitative Health Sciences Publications

BACKGROUND: Heart failure patients have high rates of repeat acute care use. Current efforts for risk prediction often ignore postdischarge data.

OBJECTIVE: To identify postdischarge patient-reported clinical factors associated with repeat acute care use.

RESEARCH DESIGN: In a prospective cohort study that followed patients with chronic heart failure for 30 days postdischarge, for 7 days after discharge (or fewer days if patients used acute care within 7 days postdischarge), patients reported health status, heart failure symptoms, medication management, knowledge of follow-up plans, and other issues using a daily interactive automatic phone call.

SUBJECTS: A total of 156 patients who had ...


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