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Female Urogenital Diseases and Pregnancy Complications Commons

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Endometriosis And Ovarian Cancer: Links, Risks, And Challenges Faced, Mary Ellen Pavone, Brianna M. Lyttle 2015 Northwestern University

Endometriosis And Ovarian Cancer: Links, Risks, And Challenges Faced, Mary Ellen Pavone, Brianna M. Lyttle

Open Access Articles

Endometriosis is a benign gynecological condition characterized by specific histological, molecular, and clinical findings. It affects 5%-10% of premenopausal women, is a cause of infertility, and has been implicated as a precursor for certain types of ovarian cancer. Advances in technology, primarily the ability for whole genome sequencing, have led to the discovery of new mutations and a better understanding of the function of previously identified genes and pathways associated with endometriosis associated ovarian cancers (EAOCs) that include PTEN, CTNNB1 (beta-catenin), KRAS, microsatellite instability, ARID1A, and the unique role of inflammation in the development of EAOC. Clinically, EAOCs are ...


Circulating Levels Of Sflt1 Splice Variants As Predictive Markers For The Development Of Preeclampsia, Colby A. Souders, Sharon E. Maynard, Jing Yan, Yan Wang, Naomi Boatright, Jessica Sedan, David Balyozian, Peter S. Cheslock, Deborah C. Molrine, Tiffany A. Moore Simas 2015 University of Massachusetts Medical School

Circulating Levels Of Sflt1 Splice Variants As Predictive Markers For The Development Of Preeclampsia, Colby A. Souders, Sharon E. Maynard, Jing Yan, Yan Wang, Naomi Boatright, Jessica Sedan, David Balyozian, Peter S. Cheslock, Deborah C. Molrine, Tiffany A. Moore Simas

Obstetrics and Gynecology Publications and Presentations

Angiogenic biomarkers, including soluble fms-like tyrosine kinase 1 (sFlt1), are thought to be predictors of preeclampsia onset; however, improvement is needed before a widespread diagnostic test can be utilized. Here we describe the development and use of diagnostic monoclonal antibodies specific to the two main splice variants of sFlt1, sFlt1-1 and sFlt1-14. These antibodies were selected for their sensitivity and specificity to their respective sFlt1 isoform in a capture ELISA format. Data from this pilot study suggest that sFlt1-1 may be more predictive of preeclampsia than total sFlt1. It may be possible to improve current diagnostic platforms if more specific ...


The Effect Of An Educational Intervention On Knowledge And Intent To Participate In Cervical Cancer Screening, Ann Marie Trapp 2015 Valparaiso University

The Effect Of An Educational Intervention On Knowledge And Intent To Participate In Cervical Cancer Screening, Ann Marie Trapp

Evidence-Based Practice Project Reports

Globally, cervical cancer ranks third among cancers affecting women (Arbyn et al., 2013). In the United States, approximately 12,000 women are diagnosed with cervical cancer and approximately 4,000 women die yearly (Centers for Disease Control and Prevention, 2014). Papanicolaou (Pap) screening is an effective means of detecting precancerous cell changes of the cervix with early cervical cancer diagnosis carrying a 91% five-year survival rate (Gonzalez et al., 2012). The purpose of this evidence-based practice project was to identify interventions that increase adherence to cervical cancer screening and to implement best practices to reduce unnecessary deaths related to late ...


Decade-Long Trends (1999-2009) In The Characteristics, Management, And Hospital Outcomes Of Patients Hospitalized With Acute Myocardial Infarction With Prior Diabetes And Chronic Kidney Disease, Mayra Tisminetzky, David D. McManus, Alon Dor, Ruben Miozzo, Jorge L. Yarzebski, Joel M. Gore, Robert J. Goldberg 2015 University of Massachusetts Medical School

Decade-Long Trends (1999-2009) In The Characteristics, Management, And Hospital Outcomes Of Patients Hospitalized With Acute Myocardial Infarction With Prior Diabetes And Chronic Kidney Disease, Mayra Tisminetzky, David D. Mcmanus, Alon Dor, Ruben Miozzo, Jorge L. Yarzebski, Joel M. Gore, Robert J. Goldberg

Open Access Articles

BACKGROUND: Despite the increasing magnitude and impact, there are limited data available on the clinical management and in-hospital outcomes of patients who have diabetes mellitus (DM) and chronic kidney disease (CKD) at the time of hospitalization for acute myocardial infarction (AMI). The objectives of our population-based observational study in residents of central Massachusetts were to describe decade-long trends (1999-2009) in the characteristics, in-hospital management, and hospital outcomes of AMI patients with and without these comorbidities.

METHODS: We reviewed the medical records of 6,018 persons who were hospitalized for AMI on a biennial basis between 1999 and 2009 at all ...


Identification Of Transcription Factors Gzf3, Rfx1, Orf19.3928 As Being Implicated In Candida-Bacterial Interactions., Joni Watson 2015 East Tennessee State University

Identification Of Transcription Factors Gzf3, Rfx1, Orf19.3928 As Being Implicated In Candida-Bacterial Interactions., Joni Watson

Undergraduate Honors Theses

Candida albicans is an opportunistic pathogen that is present in the normal flora in a majority of individuals. One key factor in C. albicans virulence is the ability to change its morphology from yeast to an elongated or hyphal form. The regulation of this morphogenesis relies in part upon quorum sensing (QS) molecules. C. albicans often exists as part of a mixed culture alongside other microbes and is influenced by their presence as well as the presence of QS molecules that they produce. In this study, a library of diploid homozygous transcriptional regulator knockout (TRKO) mutants were screened to identify ...


Maternal Obesity And Incidence Of Depression, Caroline A. Habjan 2015 Syracuse University

Maternal Obesity And Incidence Of Depression, Caroline A. Habjan

Syracuse University Honors Program Capstone Projects

Obesity is a national epidemic in the United States, which both directly and indirectly affects the social productivity of individuals, the American macro economy and individuals’ personal health and well being. Depression often interferes with an individual’s ability to work, sleep, study, eat, and enjoy life. A maternal state of both obesity and depression may cause serious adverse medical conditions in the mother’s child. Taking steps to treat depression and obesity are critical in the construct of modern medicine. This project yields results that have the potential to make treatment options better tailored, more efficient, effective and economically-sound ...


Serum Omentin As A Potential Biomarker For Complex Atypical Hyperplasia And Endometrioid Endometrial Adenocarcinoma, Laura L. Holman MD 2015 The University of Texas Graduate School of Biomedical Sciences at Houston

Serum Omentin As A Potential Biomarker For Complex Atypical Hyperplasia And Endometrioid Endometrial Adenocarcinoma, Laura L. Holman Md

UT GSBS Dissertations and Theses (Open Access)

Obesity is a significant risk factor for endometrial cancer, the most common gynecologic malignancy in the United States, but much remains unclear about the relationship between obesity-related factors and the development of endometrial cancer. Omentin, a recently discovered adipokine, has been shown to be present in lower levels in patients who are obese and/or insulin resistant. A case-control study was conducted using the serum of 140 women with endometrial cancer and 75 women with endometrial hyperplasia who were matched 1:1 based on body mass index (BMI) and menopausal status to women with no history of endometrial cancer (controls ...


Causal Inference Methods For Assessing Neurodevelopment In Children Following Prenatal Exposure To Triptan Medications: A Dissertation, Mollie E. Wood 2015 University of Massachusetts Medical School Worcester

Causal Inference Methods For Assessing Neurodevelopment In Children Following Prenatal Exposure To Triptan Medications: A Dissertation, Mollie E. Wood

GSBS Dissertations and Theses

Background: Migraine headache is a chronic pain condition that affects 20% of women of reproductive age, and is often treated with triptans. Triptans are serotonin 1B, 1D, and 1F receptor agonists that act as vasoconstrictors and inhibitors of the trigeminal cervical complex as well as peripheral neurons; they cross the blood brain barrier and placenta, and as such are plausible neurodevelopmental teratogens. No studies have examined risk of neurodevelopmental problems in children with prenatal triptan exposure. This dissertation had three aims: (1) to examine risk of behavioral problems in children using in the presence of time-varying confounding by concomitant medication ...


Gestational Diabetes, David D. Monin 2015 St. John Fisher College

Gestational Diabetes, David D. Monin

Biology Undergraduate

No abstract provided.


Targeted Single Molecule Sequencing Methodology For Ovarian Hyperstimulation Syndrome., Funda Orkunoglu-Suer, Arthur F. Harralson, David Frankfurter, Paul Gindoff, Travis J. O'Brien 2015 George Washington University

Targeted Single Molecule Sequencing Methodology For Ovarian Hyperstimulation Syndrome., Funda Orkunoglu-Suer, Arthur F. Harralson, David Frankfurter, Paul Gindoff, Travis J. O'Brien

Genomics and Precision Medicine Faculty Publications

BACKGROUND: One of the most significant issues surrounding next generation sequencing is the cost and the difficulty assembling short read lengths. Targeted capture enrichment of longer fragments using single molecule sequencing (SMS) is expected to improve both sequence assembly and base-call accuracy but, at present, there are very few examples of successful application of these technologic advances in translational research and clinical testing. We developed a targeted single molecule sequencing (T-SMS) panel for genes implicated in ovarian response to controlled ovarian hyperstimulation (COH) for infertility.

RESULTS: Target enrichment was carried out using droplet-base multiplex polymerase chain reaction (PCR) technology (RainDance ...


Effects Of Smoking Vs. Nicotine Replacement Therapy During Pregnancy On Childhood Health Outcomes: An Integrative Literature Review, Andrew J. McBride, Kristen P. Sabo, Emily D. Williams 2015 Cedarville University

Effects Of Smoking Vs. Nicotine Replacement Therapy During Pregnancy On Childhood Health Outcomes: An Integrative Literature Review, Andrew J. Mcbride, Kristen P. Sabo, Emily D. Williams

The Research and Scholarship Symposium

PICOT: In pregnant women does the use of nicotine replacement therapy compared to smoking during pregnancy reduce the risk of future childhood health concerns?

Methods: A search was conducted on healthcare literature databases (Alt HealthWatch, AMED, CINAHL, and Medline).The initial search yielded 940 results related to the topic. Initial review narrowed the search to 25 articles. Articles were excluded if published before 2008. After reviewing the full articles and evaluating effectiveness of the studies, 12 studies met the criteria. These 12 articles focused on the effects of smoking and childhood outcomes, NRT, and success of NRT.

Findings: The articles ...


Understanding Multifactorial Influences On The Continuum Of Maternal Weight Trajectories In Pregnancy And Early Postpartum: Study Protocol, And Participant Baseline Characteristics, Tiffany A. Moore Simas, Silvia Corvera, Mary M. Lee, Ningning Zhang, Katherine Leung, Barbara C. Olendzki, Bruce A. Barton, Milagros C. Rosal 2015 University of Massachusetts Medical School

Understanding Multifactorial Influences On The Continuum Of Maternal Weight Trajectories In Pregnancy And Early Postpartum: Study Protocol, And Participant Baseline Characteristics, Tiffany A. Moore Simas, Silvia Corvera, Mary M. Lee, Ningning Zhang, Katherine Leung, Barbara C. Olendzki, Bruce A. Barton, Milagros C. Rosal

Open Access Articles

BACKGROUND: Maternal and offspring immediate and long-term health are affected by pregnancy weight gain and maternal weight. This study was designed to determine feasibility of: 1) recruiting a socio-economically and racially/ethnically diverse sample of pregnant women into a longitudinal observational study, including consenting the women for serial biologic specimen evaluations; 2) implementing comprehensive assessments (including biologic, anthropometric, behavioral, cognitive/psychosocial and socio-demographic, and cultural measures) at multiple time points over the study period, including collecting biologic specimens at planned and unplanned pregnancy delivery times; and 3) retaining the sample for one year into the postpartum period. Additionally, the study ...


Cervical Cancer, Anne Garrison, Andrew H. Fischer, Adib R. Karam, Antonella Leary, Richard S. Pieters 2015 University of Massachusetts Medical School

Cervical Cancer, Anne Garrison, Andrew H. Fischer, Adib R. Karam, Antonella Leary, Richard S. Pieters

Cancer Concepts: A Guidebook for the Non-Oncologist

This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist presents provides an overview of cervical cancer. The etiology, pathology, staging, and principles of treatment will be reviewed.


Diet Quality And History Of Gestational Diabetes Mellitus Among Childbearing Women, United States, 2007-2010, Rui Sherry Xiao, Tiffany A. Moore Simas, Sharina D. Person, Robert J. Goldberg, Molly E. Waring 2015 University of Massachusetts Medical School

Diet Quality And History Of Gestational Diabetes Mellitus Among Childbearing Women, United States, 2007-2010, Rui Sherry Xiao, Tiffany A. Moore Simas, Sharina D. Person, Robert J. Goldberg, Molly E. Waring

Population and Quantitative Health Sciences Publications

INTRODUCTION: Women with a history of gestational diabetes mellitus (GDM) have elevated risk of developing type 2 diabetes. Diet quality plays an important role in the prevention of type 2 diabetes. We compared diet quality among childbearing women with a history of GDM with the diet quality of childbearing women without a history of GDM.

METHODS: We used data from the National Health and Nutrition Examination Survey for 2007 through 2010. We included women without diabetes aged 20 to 44 years whose most recent live infant was born within the previous 10 years and who completed two 24-hour dietary recalls ...


Does Treatment With Onabotulinumtoxina Improve The Quality Of Life In Patients With Urinary Incontinence Not Adequately Controlled With Anticholinergics?, Victoria J. Kopec 2015 Philadelphia College of Osteopathic Medicine

Does Treatment With Onabotulinumtoxina Improve The Quality Of Life In Patients With Urinary Incontinence Not Adequately Controlled With Anticholinergics?, Victoria J. Kopec

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not treatment with onabotulinumtoxinA improves the quality of life in patients with urinary incontinence not adequately controlled with anticholinergics.

STUDY DESIGN: Review of three English language, randomized controlled trials published in 2013.

DATA SOURCES: Randomized, double-blind, controlled clinical trials comparing onabotulinumtoxinA intradetrusor injections with saline placebo. All articles were found using PubMed.

OUTCOMES MEASURED: Each of the three trials assessed the patient’s quality of life after treatment with onabotulinumtoxinA using the following assessment tools: Incontinence Quality of Life Questionnaire (I-QOL), Modified Overactive Bladder Patient Satisfaction with ...


Estudio Parto: Postpartum Diabetes Prevention Program For Hispanic Women With Abnormal Glucose Tolerance In Pregnancy: A Randomised Controlled Trial - Study Protocol, Lisa Chasan-Taber, Bess H. Marcus, Milagros C. Rosal, Katherine L. Tucker, Sheri J. Hartman, Penelope S. Pekow, Barry Braun, Tiffany A. Moore Simas, Caren G. Solomon, Joann E. Manson, Glenn Markenson 2014 University of Massachusetts, Amherst

Estudio Parto: Postpartum Diabetes Prevention Program For Hispanic Women With Abnormal Glucose Tolerance In Pregnancy: A Randomised Controlled Trial - Study Protocol, Lisa Chasan-Taber, Bess H. Marcus, Milagros C. Rosal, Katherine L. Tucker, Sheri J. Hartman, Penelope S. Pekow, Barry Braun, Tiffany A. Moore Simas, Caren G. Solomon, Joann E. Manson, Glenn Markenson

Tiffany A. Moore Simas

BACKGROUND: Diabetes and obesity have reached epidemic proportions in the U.S. with rates consistently higher among Hispanics as compared to non-Hispanic whites. Among Hispanic women diagnosed with gestational diabetes mellitus (GDM), 50% will go on to develop type 2 diabetes within 5 years of the index pregnancy. Although randomised controlled trials among adults with impaired glucose tolerance have shown that diet and physical activity reduce the risk of type 2 diabetes, such programs have not been tested in high-risk postpartum women. The overall goal of this randomised controlled trial is to test the efficacy of a culturally and linguistically ...


Endometrial Cancer, Richard S. Pieters, Maryanne Bombaugh, Yuxin Liu, Gina Cunto-Amesty, Adib R. Karam, Elizabeth Kurian, Sarah Huges 2014 University of Massachusetts Medical School

Endometrial Cancer, Richard S. Pieters, Maryanne Bombaugh, Yuxin Liu, Gina Cunto-Amesty, Adib R. Karam, Elizabeth Kurian, Sarah Huges

Cancer Concepts: A Guidebook for the Non-Oncologist

This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist is about cancers of the endometrium and uterus, including the epidemiology, risk factors, diagnosis, genetic risk, histology, grading and type categorization, management, and prognosis.


Transitional Cell Carcinomas Of The Urinary Bladder. A Histopathological Study, Z. Ahmed, S. Muzaffer, M. Khan, N. Kayani, Shahid Pervez, A. S. Husseini, S H. Hasan 2014 Aga Khan University

Transitional Cell Carcinomas Of The Urinary Bladder. A Histopathological Study, Z. Ahmed, S. Muzaffer, M. Khan, N. Kayani, Shahid Pervez, A. S. Husseini, S H. Hasan

Shahid Pervez

Objective: To determine the histological grading and muscle invasion in Transitional Cell Carcinomas of the Urinary Bladder; and to evaluate whether any correlation exists between tumour grade and muscle invasion. Method: A Retrospective study of all consecutive cases of Transitional Cell Carcinomas of the Urinary Bladder diagnosed at Aga Khan University Hospital between 1st Jan 1997 and 31st Dec 2000. Results: This study included 495 cases of Transitional Cell Carcinoma of the Urinary Bladder. M: F ratio was 4:1. Ages of patients ranged from 30 years to 87 years. Mean age in males was 59.1 years and in ...


Missed Opportunities In Hpv Vaccination, B. Dale Magee, AuTumn S. Davidson, Leslie Regh 2014 University of Massachusetts Medical School

Missed Opportunities In Hpv Vaccination, B. Dale Magee, Autumn S. Davidson, Leslie Regh

B. Dale Magee

Objective: To use the 3 dose Human Papillomavirus (HPV) vaccine administration (given at 0, 1-2 and 6 months) to quantify opportunities to improve efficacy in the delivery of preventive health services. Methods: This was a retrospective, claims-based analysis using data provided by a single managed care plan. Female patients aged 9-26 who were continuously enrolled between 2009 through 2011 and received ≥ dose of the HPV vaccine during 2010 were analyzed. The proportion of initiators who did and did not completed the vaccine series, the timing and location of doses, and the number of outpatient visits during which the vaccine could ...


Effect Of Pegloticase On Renal Function In Patients With Chronic Kidney Disease: A Post Hoc Subgroup Analysis Of 2 Randomized, Placebo-Controlled, Phase 3 Clinical Trials, Robert A. Yood, Faith D. Ottery, William Irish, Marsha Wolfson 2014 Reliant Medical Group

Effect Of Pegloticase On Renal Function In Patients With Chronic Kidney Disease: A Post Hoc Subgroup Analysis Of 2 Randomized, Placebo-Controlled, Phase 3 Clinical Trials, Robert A. Yood, Faith D. Ottery, William Irish, Marsha Wolfson

Robert A. Yood

BACKGROUND: Pegloticase is approved in the US for treatment of refractory chronic gout. Since chronic kidney disease (CKD) is common in these patients, we conducted a post-hoc analysis of 2 replicate phase 3 trials and the subsequent open-label extension study to determine the effects of pegloticase on renal function in patients with CKD stages 3 and 4, as well as the effects of renal dysfunction on pegloticase efficacy and safety. FINDINGS: Patients with renal insufficiency were randomized to pegloticase 8 mg every 2 weeks (n = 42), pegloticase 8 mg every 4 weeks (n = 41), or placebo (n = 20) for 6 ...


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