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A Case Of Disseminated Nocardia Beijingensis In An Immunocompetent Patient, Manifesting As Subcutaneous And Cns Nocardiosis., Scott Cathcart, Patricia Stogsdill, Rebecca Bell 2020 Maine Medical Center

A Case Of Disseminated Nocardia Beijingensis In An Immunocompetent Patient, Manifesting As Subcutaneous And Cns Nocardiosis., Scott Cathcart, Patricia Stogsdill, Rebecca Bell

Journal of Maine Medical Center

Introduction

Nocardiosis is an uncommon infection, typically encountered in immunocompromised patients. With only 5 cases reported thus far in the United States, we present a case of disseminated Nocardia beijingensis in an immunocompetent patient, involving the lung, subcutaneous tissue, and CNS.

Clinical Findings

A 60-year-old immunocompetent male with no significant medical history presents to our institution after a complicated medical course, beginning with vague respiratory complaints. Initial work-up revealed a large right upper lung mass of unclear etiology. A month later he had a syncopal episode followed by the development of focal neurologic deficits.

Main Diagnoses, Therapeutics Interventions, and Outcomes ...


Contributions Of Gyra And Parc Mutations And Qnrs2 Acquisition To Ciprofloxacin Resistance In Aeromonas Veronii Hm21, Daniel J. Silverstein 2020 University of Connecticut

Contributions Of Gyra And Parc Mutations And Qnrs2 Acquisition To Ciprofloxacin Resistance In Aeromonas Veronii Hm21, Daniel J. Silverstein

Honors Scholar Theses

In recent years, ciprofloxacin resistant (CpR) Aeromonas veronii and A. hydrophila strains have been isolated from the wounds of patients receiving leech therapy. Genome comparisons of these CpR isolates revealed the presence of chromosomal mutations in gyrA and parC as well as the gain of qnrS2 on either a large, 34 kb, conjugatable, low-copy plasmid, pAv42, or on a small, 6.8 kb, high-copy plasmid, pAh1471. The minimum inhibitory concentration, MIC, for Cp of these clinical isolates ranged from 1 to ≥32 µg/mL and some harbored a qnrS2 containing plasmid. We wanted to assess the contributions of these factors ...


Pasteurella Multocida Bacteremia Secondary To Multiple Cat Scratches, Charles Boadu MD, Andrea Hernandez MD, Bassem Zeidan MD, John T. Young MD, Johnathan Frunzi MD 2020 HCA Healthcare

Pasteurella Multocida Bacteremia Secondary To Multiple Cat Scratches, Charles Boadu Md, Andrea Hernandez Md, Bassem Zeidan Md, John T. Young Md, Johnathan Frunzi Md

West Florida Division Virtual Research Day

Pasteurella multocida(P. multocida)is part of the normal gastrointestinal and upper respiratory flora of domestic and wild animals such as dogs, cats, rabbits, opossums, boars, tigers, lions and horses (1, 2). Transmission of P. multocidais usually through scratches and bites leading to infections of the soft tissue and skin (3,4). P. multocida bacteremia is rare, but occurs in individuals with major risk factors including chronic pulmonary disease, diabetes mellitus, end state renal disease (ESRD), and an immunocompromised state (3,4). Non traumatic infections of P. multocida in immunocompromised individuals,are more likely to require care in the intensive ...


A Case Of Pott's Disease: Typical Presentation Of An Uncommon Disease In The United States, Neha Patel MD, Ravi Patel MD, Marek Krysztofiak MD, K V. Sundaresh MD 2020 HCA Healthcare

A Case Of Pott's Disease: Typical Presentation Of An Uncommon Disease In The United States, Neha Patel Md, Ravi Patel Md, Marek Krysztofiak Md, K V. Sundaresh Md

West Florida Division Virtual Research Day

Pott’s disease (PD), also known as tuberculosis spondylitis, is a rare disease of the spine which is typically caused by extraspinal infection. The basic lesion in Pott's disease is a combination of osteomyelitis and arthritis, usually affecting more than one vertebra. The anterior aspect of the vertebral body adjacent to the subchondral plate is commonly involved. Spinal TB can include any of the following: progressive bone destruction leading to vertebral collapse and kyphosis, cold abscess formation (due to extension of infection into adjacent ligaments and soft tissues), spinal canal narrowing by abscesses, granulation tissue or direct dural invasionresulting ...


Network Modeling The Impact Of Community-Based Male-Screening On The Chlamydia Trachomatis Prevalence In Women, Zhuolin Qu 2020 Virginia Commonwealth University

Network Modeling The Impact Of Community-Based Male-Screening On The Chlamydia Trachomatis Prevalence In Women, Zhuolin Qu

Biology and Medicine Through Mathematics Conference

No abstract provided.


Evaluation Of Il-1 Blockade As An Adjunct To Linezolid Therapy For Tuberculosis In Mice And Macaques, Caylin G. Winchell, Bibhuti B. Mishra, Jia Yao Phuah, Samantha J. Nelson, Christopher M. Sassetti, JoAnne L. Flynn 2020 University of Pittsburgh

Evaluation Of Il-1 Blockade As An Adjunct To Linezolid Therapy For Tuberculosis In Mice And Macaques, Caylin G. Winchell, Bibhuti B. Mishra, Jia Yao Phuah, Samantha J. Nelson, Christopher M. Sassetti, Joanne L. Flynn

Open Access Articles

In 2017 over 550,000 estimated new cases of multi-drug/rifampicin resistant tuberculosis (MDR/RR-TB) occurred, emphasizing a need for new treatment strategies. Linezolid (LZD) is a potent antibiotic for drug-resistant Gram-positive infections and is an effective treatment for TB. However, extended LZD use can lead to LZD-associated host toxicities, most commonly bone marrow suppression. LZD toxicities may be mediated by IL-1, an inflammatory pathway important for early immunity during M. tuberculosis infection. However, IL-1 can contribute to pathology and disease severity late in TB progression. Since IL-1 may contribute to LZD toxicity and does influence TB pathology, we targeted ...


Light Forge: A Microfluidic Dna Melting-Based Tuberculosis Test, Ian M. Mbano, Tawanda Mandizvo, Jerome Rogich, Tafara T. R. Kunota, Jared S. Mackenzie, Manormoney Pillay, Frederick K. Balagadde 2020 University of KwaZulu Natal

Light Forge: A Microfluidic Dna Melting-Based Tuberculosis Test, Ian M. Mbano, Tawanda Mandizvo, Jerome Rogich, Tafara T. R. Kunota, Jared S. Mackenzie, Manormoney Pillay, Frederick K. Balagadde

Open Access Articles

BACKGROUND: There is a well-documented lack of rapid, low-cost tuberculosis (TB) drug resistance diagnostics in low-income settings across the globe. It is these areas that are plagued with a disproportionately high disease burden and in greatest need of these diagnostics.

METHODS: In this study, we compared the performance of Light Forge, a microfluidic high-resolution melting analysis (HRMA) prototype for rapid low-cost detection of TB drug resistance with a commercial HRMA device, a predictive "nearest-neighbor" thermodynamic model, DNA sequencing, and phenotypic drug susceptibility testing (DST). The initial development and assessment of the Light Forge assay was performed with 7 phenotypically drug ...


Characterization Of A Mycoplasma Pneumoniae Cards Toxin Mutant, Nikaash Pasnoori 2020 University of Connecticut

Characterization Of A Mycoplasma Pneumoniae Cards Toxin Mutant, Nikaash Pasnoori

Honors Scholar Theses

Mycoplasma pneumoniae is a high-burden pathogen which causes mild to significant infections of the respiratory system. According to the CDC, an estimated two million cases occur yearly in the United States alone, demonstrating the widespread effect of the pathogen. In addition to being the cause of respiratory infections, M. pneumoniae has also been implicated in exacerbating pre-existing asthma conditions. These morbidities make finding a vaccine candidate a vital part of easing the healthcare burden caused by the pathogen. The current mechanism of infection is unknown, but recent evidence points to the Community Acquired Respiratory Distress Syndrome (CARDS) toxin as being ...


Food Safety Risk In An Indoor Microgreen Cultivation System, Gina Marie Misra 2020 University of Arkansas, Fayetteville

Food Safety Risk In An Indoor Microgreen Cultivation System, Gina Marie Misra

Theses and Dissertations

Microgreens are immature sprouts of edible plants, sharing some similarities with sprouted seeds and petite leafy greens. Since they are most often grown in containers in buildings or greenhouses, they present a new area for food safety research at the intersection of the built environment and produce farming. Contamination by human pathogens has been extensively studied in other types of produce typically eaten raw, including sprouted seeds, which have been implicated in numerous outbreaks of salmonellosis over the last several decades. There is a paucity of knowledge about the microgreen sector of the fresh-cut industry; thus, it was determined that ...


New Onset Psychosis Secondary To Neurosyphilis, Samantha Linda Jane Vu DO, Lauren Angela DeMarco DO, Francis Butler MD, Nihal Shah MD 2020 HCA Healthcare

New Onset Psychosis Secondary To Neurosyphilis, Samantha Linda Jane Vu Do, Lauren Angela Demarco Do, Francis Butler Md, Nihal Shah Md

West Florida Division Virtual Research Day

Syphilis is a highly contagious sexually transmitted infection (STI) caused by the spirochetal bacterium Treponema pallidum. Transmission occurs through direct contact of painless ulcerative lesions, chancres, located on the genitalia (penis, labia) and oral mucosa. Neurosyphilis is any involvement of the central nervous systems (brain, meninges, or spinal cord) by the bacterium.


Bilateral Sporotrichoid Cutaneous Atypical Mycobacterial Infection Due To Primary Inoculation, Erin Lowe DO, Alexa Broderick, Richard Miller DO 2020 HCA Healthcare

Bilateral Sporotrichoid Cutaneous Atypical Mycobacterial Infection Due To Primary Inoculation, Erin Lowe Do, Alexa Broderick, Richard Miller Do

West Florida Division Virtual Research Day

The group of mycobacterial species that excludes Mycobacteria tuberculosis and Mycobacteria leprae is known as nontuberculosis or atypical mycobacteria. Nearly all atypical mycobacteria species can cause cutaneous infection. The diagnosis is challenging as disease may take months to become clinically apparent, morphology is non-specific, routine culture has a low sensitivity, and organisms can be sparse on histopathologic examination. Antibiotic resistance and further complicates management. The Gulf Coast is the highest incidence region of cutaneous atypical mycobacterial infections. Here we present a challenging case of bilateral sporotrichoid atypical mycobacterial infection due to primary inoculation.


Novel Infection Status Post Electrocution Requiring A 4th Ray Amputation, William R. Judson IV, DO, John D. Murphy DO, MBA, Phillip H. Sussman DO, John N. Harker DO 2020 HCA Healthcare

Novel Infection Status Post Electrocution Requiring A 4th Ray Amputation, William R. Judson Iv, Do, John D. Murphy Do, Mba, Phillip H. Sussman Do, John N. Harker Do

West Florida Division Virtual Research Day

  • Prevotella bivia is an anaerobic, non-pigmented, Gram-negative bacillus species that is known to inhabit the human female vaginal tract and oral flora. It is most commonly associated with endometritis and pelvic inflammatory disease.1, 2
  • Rarely, P. bivia has been found in the nail bed, chest wall, intervertebral discs, and hip and knee joints.1 The bacteria has been linked to necrotizing fasciitis, osteomyelitis, or septic arthritis.3, 4
  • Only 3 other reports have described P. bivia infections in the upper extremity with one patient requiring amputation2, and one with deep soft tissue infection requiring multiple debridements and extensive tenosynovectomy ...


Swimming Through Lake Placid: A Major Headache, Elizabeth Severson, Claudia Leonard 2020 Providence St. Vincent, Internal Medicine Residency, Portland, Oregon

Swimming Through Lake Placid: A Major Headache, Elizabeth Severson, Claudia Leonard

Providence St. Vincent Internal Medicine

Introduction: Leptospirosis is caused by Leptospira species, a spirochete bacterium that affects animals and humans. The disease can range from mild flu-like illness to multi-organ failure. While likely underreported, the incidence according to the World Health Organization can range from 0.1 to 10 per 100,000 depending on climate Leptospirosis is commonly associated with occupational or recreational exposures

Case Report: A 43 year-old previously healthy man presented with two weeks of myalgias, fevers, neck pain and throbbing headache. The patient competed in an Iron Man event in upstate New York one month prior to presentation. Initial investigation demonstrated a ...


Bacterial Load In Virtual Reality Headsets, Benjamin Creel 2020 University of Mississippi

Bacterial Load In Virtual Reality Headsets, Benjamin Creel

Honors Theses

Virtual reality technology is a rapidly growing field of computer science. Virtual reality utilizes headsets which cover the user’s eyes, nose, and forehead. In this study, I analyzed the potential for these headsets to become contaminated with bacteria. The nosepieces and foreheads of two HTC Vive VR headsets of the Department of Computer Science of the University of Mississippi were sampled over the course of a seven-week Immersive Media (CSCI 447) course. Serial dilutions were performed, and samples were plated on various culture media. Following incubation, counts of bacteria were determined. DNA was extracted from bacterial growth on plates ...


280— Exploring The Geographic Distribution Of Childbed Fever Deaths In Mid-19th Century Rochester, Ny, Meaghan Parks 2020 SUNY Geneseo

280— Exploring The Geographic Distribution Of Childbed Fever Deaths In Mid-19th Century Rochester, Ny, Meaghan Parks

GREAT Day

Childbed fever, formally called puerperal fever or puerperal septicemia, is an infection typically contracted by women after childbirth. Historically, childbed fever was a serious threat to maternal health. Childbed fever is caused by exposure of open wounds or abrasions, which are common after giving birth, to group A and B Streptococcal bacteria. Ignaz Semmelweis discovered that hand washing using a chlorinated solution reduced cases of childbed fever in 1847. This project reviews the instances of death from childbed fever in Rochester, New York from 1837-1860 and later from 1907-1919 and attempts to determine which areas of the city had the ...


Declines In Lung Function After Antiretroviral Therapy Initiation In Adults With Human Immunodeficiency Virus And Tuberculosis: A Potential Manifestation Of Respiratory Immune Reconstitution Inflammatory Syndrome, Sara C. Auld, Pholo Maenetje, Shruthi Ravimohan, Drew Weissman, Itai Ncube, Mandla Mlotshwa, Nelly Ratsela, William Chase, Mboyo-Di-Tamba Vangu, Robert Wallis, Gavin Churchyard, Hardy Kornfeld, Gregory P. Bisson 2020 Emory University

Declines In Lung Function After Antiretroviral Therapy Initiation In Adults With Human Immunodeficiency Virus And Tuberculosis: A Potential Manifestation Of Respiratory Immune Reconstitution Inflammatory Syndrome, Sara C. Auld, Pholo Maenetje, Shruthi Ravimohan, Drew Weissman, Itai Ncube, Mandla Mlotshwa, Nelly Ratsela, William Chase, Mboyo-Di-Tamba Vangu, Robert Wallis, Gavin Churchyard, Hardy Kornfeld, Gregory P. Bisson

Open Access Articles

End-organ impairment has received relatively little research attention as a possible manifestation of tuberculosis immune reconstitution inflammatory syndrome (TB-IRIS). In this prospective cohort study, one-half of adults with human immunodeficiency virus and pulmonary tuberculosis experienced meaningful declines in lung function on antiretroviral therapy, suggesting a role for lung function in TB-IRIS definitions.


A Novel Case Of Bacterial Meningitis In A Patient With Loeys-Dietz, Lacey D. Colvin DO, Christy Fagg 2020 HCA Healthcare

A Novel Case Of Bacterial Meningitis In A Patient With Loeys-Dietz, Lacey D. Colvin Do, Christy Fagg

Infectious Disease

No abstract provided.


Chrysin‐Loaded Chitosan Nanoparticles Potentiates Antibiofilm Activity Against Staphylococcus Aureus, Busi Siddhardha, Uday Pandey, K. Kaviyarasu, Rajasekharreddy Pala, Asad Syed, Ali K. Bahkali, Abdallah M. Elgorban 2020 Pondicherry University

Chrysin‐Loaded Chitosan Nanoparticles Potentiates Antibiofilm Activity Against Staphylococcus Aureus, Busi Siddhardha, Uday Pandey, K. Kaviyarasu, Rajasekharreddy Pala, Asad Syed, Ali K. Bahkali, Abdallah M. Elgorban

Pharmacy Faculty Articles and Research

The application of nanotechnology in medicine is gaining popularity due to its ability to increase the bioavailability and biosorption of numerous drugs. Chrysin, a flavone constituent of Orocylumineicum vent is well‐reported for its biological properties. However, its therapeutic potential has not been fully exploited due to its poor solubility and bioavailability. In the present study, chrysin was encapsulated into chitosan nanoparticles using TPP as a linker. The nanoparticles were characterized and investigated for their anti‐biofilm activity against Staphylococcus aureus. At sub‐Minimum Inhibitory Concentration, the nanoparticles exhibited enhanced anti‐biofilm efficacy against S. aureus as compared to its ...


Cryptococcal Antigen Testing In An Integrated Medical System: Eastern Wisconsin, Marianne Klumph, Brian Hoeynck, Dennis J. Baumgardner 2020 Aurora Health Care; Center for Urban Population Health

Cryptococcal Antigen Testing In An Integrated Medical System: Eastern Wisconsin, Marianne Klumph, Brian Hoeynck, Dennis J. Baumgardner

Journal of Patient-Centered Research and Reviews

Cryptococcosis is a serious environmentally acquired endemic fungal infection commonly associated with immunocompromised hosts. Little is known regarding frequency or distribution in Wisconsin. We explored the geodemographic and clinical features of patients tested with cryptococcal antigen tests (CrAg) — previously shown to be >90% sensitive and >90% specific — within a large health care system located in eastern Wisconsin. To examine this, we retrospectively analyzed 1465 CrAg tests on 1211 unique patients (female: 50.2%; white race: 73.9%; mean age: 53.7 ± 16.5 years). At least one CrAg result was positive in 23 of 1211 patients (1.9%). From these ...


Always Remember To Floss... Or Else, Arunmozhi (Sankavi) Aravagiri MD, Muhammad Zain MD, Rajesh Gulati MD 2020 HCA Healthcare

Always Remember To Floss... Or Else, Arunmozhi (Sankavi) Aravagiri Md, Muhammad Zain Md, Rajesh Gulati Md

Internal Medicine

No abstract provided.


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