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Recent Articles in Hemic and Lymphatic Diseases

Stimulation Through Tlr4 Increases Fviii Inhibitor Formation In A Mouse Model Of Hemophilia A, Claire K. Holley Texas Medical Center Library

Stimulation Through Tlr4 Increases Fviii Inhibitor Formation In A Mouse Model Of Hemophilia A, Claire K. Holley

UT GSBS Dissertations and Theses (Open Access)

Hemophilia A is a clotting disorder caused by functional factor VIII (FVIII) deficiency. About 25% of patients treated with therapeutic recombinant FVIII develop antibodies (inhibitors) that render subsequent FVIII treatments ineffective. The immune mechanisms of inhibitor formation are not entirely understood, but circumstantial evidence indicates a role for increased inflammatory response, possibly via stimulation of Toll-like receptors (TLRs), at the time of FVIII immunization. I hypothesized that stimulation through TLR4 in conjunction with FVIII treatments would increase the formation of FVIII inhibitors. To test this hypothesis, FVIII K.O. mice were injected with recombinant human FVIII with or without concomitant ...

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Preventing Iron-Deficiency Anemia In Children In Developing Countries — Why It Is Necessary And How It Must Be Approached, Nupur Dogra McMaster University

Preventing Iron-Deficiency Anemia In Children In Developing Countries — Why It Is Necessary And How It Must Be Approached, Nupur Dogra

The Meducator

Iron deficiency (ID) has been identified as the most common nutritional deficiency condition in the world, with a high prevalence in both developed and developing countries. ID and iron-deficiency anemia (IDA) affect the cognitive, socioemotional and motor development of children. Using evidence from 2002 onwards, a literature review of the impact of ID and IDA on child development and the interventions preventing them was conducted. Review of recent evidence presents 1) altered cognitive functions, 2) decreased socio-emotional development, and 3) impediment of motor skills development due to ID and IDA . In conclusion, the effects of ID and IDA on child ...

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Parkland College

McMaster University

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Laura Swystun McMaster University

Hui Zhang Texas Medical Center Library

Jacqueline Tally University of Rhode Island

Job Dekker University of Massachusetts Medical School

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Popular Articles

Sickle Cell Anemia

Modulation Of Hemostatic Pathways By Breast Cancer Chemotherapy Agents, Laura Swystun

Biological Mechanisms And Clinical Implications Of Bcr-Abl-Induced Mitochondrial Oxidative Stress And Cell Survival In Chronic Myeloid Leukemia, Hui Zhang

Identifying The Relationship Between Benzene Exposure And The Development Of Acute Myeloid Leukemia, Jacqueline Tally

Chemical Genetic Strategy Identifies Histone Deacetylase 1 (Hdac1) And Hdac2 As Therapeutic Targets In Sickle Cell Disease, Job Dekker

Clinical Diagnosis

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