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Digestive System Diseases Commons

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Similac Special Care And Elecare Cause Neonatal Gut Injury In Mice, Karishma Rao, Heather L. Menden, Wei Yu, Inamul Haque, Susana Chavez-Bueno, Alain C. Cuna, Shahid Umar, Venkatesh Sampath 2020 CMH

Similac Special Care And Elecare Cause Neonatal Gut Injury In Mice, Karishma Rao, Heather L. Menden, Wei Yu, Inamul Haque, Susana Chavez-Bueno, Alain C. Cuna, Shahid Umar, Venkatesh Sampath

Research Days

No abstract provided.


Methotrexate Polyglutamates As Biomarkers Of Treatment Response In Ibd Vs. Jia, Ryan Morrow 2020 Children's Mercy Kansas City

Methotrexate Polyglutamates As Biomarkers Of Treatment Response In Ibd Vs. Jia, Ryan Morrow

Research Days

No abstract provided.


The Role Of Nutrition In Promoting Gut Health And Treating Chronic Illness Through The Attenuation Of Inflammation, Allison Dalton 2020 HCA

The Role Of Nutrition In Promoting Gut Health And Treating Chronic Illness Through The Attenuation Of Inflammation, Allison Dalton

HCA Healthcare Journal of Medicine

Over the millennia, the human body and microorganisms such as bacteria, viruses, archaea, protozoa and parasites have coevolved together forming an intimate relationship. These microorganisms are found on the skin, in the mouth, genitourinary tract and most abundantly in the large intestine of the digestive tract. States of microbial dysbiosis contribute to chronic inflammation, which can lead to the pathogenesis and progression of numerous diseases. Micro- and macro-nutrients as well as dietary patterns like the Mediterranean diet can help improve health outcomes.


Association Of Race/Ethnicity And Population Density With Disparities In Timeliness Of Rectal Cancer Therapy, Susanna S. Hill 2020 University of Massachusetts Medical School

Association Of Race/Ethnicity And Population Density With Disparities In Timeliness Of Rectal Cancer Therapy, Susanna S. Hill

GSBS Dissertations and Theses

Objective:

Access to care is key to effective rectal cancer treatment. We hypothesized that ethnic/racial minorities living in high population density areas would have the greatest delays in cancer care compared to whites living in medium population density areas.

Methods:

Using 2004-2016 National Cancer DataBase data, we identified stage I-III patients with invasive rectal adenocarcinoma who underwent surgery. The data were analyzed by race/ethnicity (whites, blacks, or Hispanics) and population density (metropolitan or urban/rural). Multivariable ANCOVA was performed to evaluate the duration of time from diagnosis to surgery.

Results:

The study population consisted of 76,131 patients ...


The Inflammatory Bowel Disease Questionnaire In Randomized Controlled Trials Of Treatment For Ulcerative Colitis: Systematic Review And Meta-Analysis, Aaron Yarlas, Stephen Maher, Martha Bayliss, Andrew Lovley, Joseph C. Cappelleri, Andrew G. Bushmakin, Marco D. DiBonaventura 2020 Optum, Inc.

The Inflammatory Bowel Disease Questionnaire In Randomized Controlled Trials Of Treatment For Ulcerative Colitis: Systematic Review And Meta-Analysis, Aaron Yarlas, Stephen Maher, Martha Bayliss, Andrew Lovley, Joseph C. Cappelleri, Andrew G. Bushmakin, Marco D. Dibonaventura

Journal of Patient-Centered Research and Reviews

Purpose: The 32-item Inflammatory Bowel Disease Questionnaire (IBDQ-32) is the most frequently used instrument to capture disease-specific quality of life in randomized clinical trials for ulcerative colitis. This review and meta-analysis provides the first synthesis of evidence regarding the sensitivity of IBDQ-32 total and domain scores to treatment efficacy.

Methods: A systematic literature search and risk-of-bias assessment yielded 14 articles that were included in the primary analysis. Treatments were categorized as efficacious if they met the primary efficacy endpoint (which was not the IBDQ-32); otherwise they were categorized as non-efficacious. A continuous measure of treatment efficacy was calculated for each ...


A Systematic Search And Review On The Efficacy, Safety, And Cost-Effectiveness Of Utilizing Lactobacillus Probiotics In Concurrence With Prescribing Antibiotics To Reduce Clostridium Difficile Infection Rates In Hospitalized Patients, Laura Sheehan 2020 Winona State University

A Systematic Search And Review On The Efficacy, Safety, And Cost-Effectiveness Of Utilizing Lactobacillus Probiotics In Concurrence With Prescribing Antibiotics To Reduce Clostridium Difficile Infection Rates In Hospitalized Patients, Laura Sheehan

Nursing Masters Papers

Incidence of Clostridium difficile infection, (CDI) in patients receiving antibiotics is significant. In 2017, there were approximately 223,900 cases of CDI in hospitalized patients alone (Center for Disease Control [CDC], 2017). Despite enhanced infection control measures, CDI rates remain prevalent and are associated with increased costs to healthcare. An integrative literature review and synthesis was performed. Studies were analyzed to delineate if Lactobacillus containing probiotics, when administered concurrently with high risk antibiotics, decrease CDI rates for patients in the inpatient hospital setting. Additional analysis of probiotic safety and a cost versus benefit analysis was researched. The purpose of the ...


Novel Method Of Supplementing Current Depression Treatments: Using Autonomous Sensory Meridian Response-Centered Therapy To Improve Constipation-Associated Comorbidity Of Depression, Shivam Patel 2020 Virginia Commonwealth University

Novel Method Of Supplementing Current Depression Treatments: Using Autonomous Sensory Meridian Response-Centered Therapy To Improve Constipation-Associated Comorbidity Of Depression, Shivam Patel

Virginias Collegiate Honors Council Conference

One-third of individuals struggling with constipation also suffer chronically from comorbid depression, but the evidently shared etiology has remained relatively ambiguous. This proposed study aims to analyze the role of Autonomous Sensory Meridian Response (ASMR), a newly recorded neural phenomenon that causes relaxing “tingles” from unique “triggers” in a subset of individuals, in altering serotonin (5-HT) levels within the ENS to aid with both depression and constipation. In depressed individuals, reduced 5-HT has been clinically accepted as a key symptom and is frequently treated with ineffective SSRIs. Prospective alternative methods of non-invasive treatment, such as ASMR, would not only aid ...


Quality Improvement In Ibd Care: The Influence Of A Qi Specific Conference For Fellows, Olayinka Afolabi, Alexis Faber, Raya Kutaimy, Paul Naylor, Murray Ehrinpreis 2020 Wayne State University

Quality Improvement In Ibd Care: The Influence Of A Qi Specific Conference For Fellows, Olayinka Afolabi, Alexis Faber, Raya Kutaimy, Paul Naylor, Murray Ehrinpreis

Medical Student Research Symposium

Given the complexity of management of inflammatory bowel disease (IBD), medical societies such as the American Gastroenterological Association (AGA) and Crohn’s and Colitis Foundation of America (CCFA) have established measures aimed at defining quality of care. In 2011, the AGA proposed 10 quality metrics for IBD, eight of these measures relate to outpatient management and two focus on inpatient management. Our objective was to evaluate compliance with these measures in our own general GI practice and determine whether a GI conference discussing quality improvement (QI) in 2017 was effective.


Targeting Epigenetic Mechanisms To Alleviate Alcoholic Steatosis, Pranoti Mandrekar 2020 University of Massachusetts Medical School

Targeting Epigenetic Mechanisms To Alleviate Alcoholic Steatosis, Pranoti Mandrekar

Open Access Articles

Alcohol-related liver disease (ALD) is a major health concern and recent studies have reported nearly 1 million alcohol-related deaths from 1999 to 2017 in the United States.1 ALD is a spectrum of conditions that ranges from early steatosis or fatty liver to inflammation or alcoholic steatohepatitis progressing to fibrosis and cirrhosis. Approximately 8%–20% of alcoholic steatohepatitis patients develop cirrhosis and, in some, alcoholic steatohepatitis can present in the form of acute-on-chronic liver failure, termed alcoholic hepatitis, owing to excessive drinking episodes. Corticosteroids are the first line of therapy for ALD, however, only marginal short-term survival benefit in patients ...


Budd-Chiari Syndrome From A Tunneled-Dialysis Catheter?, Ifrah Butt MD, Kairavee D. Dave MD, Lucas Rindy DO, Arash Zarrin DO, Livasky Concepcion MD, Daniel Heller MD, Franklin Kasmin MD, Steven Kaplan MD, John Rivas MD 2020 HCA Healthcare

Budd-Chiari Syndrome From A Tunneled-Dialysis Catheter?, Ifrah Butt Md, Kairavee D. Dave Md, Lucas Rindy Do, Arash Zarrin Do, Livasky Concepcion Md, Daniel Heller Md, Franklin Kasmin Md, Steven Kaplan Md, John Rivas Md

Internal Medicine

No abstract provided.


A Rare Case Of Perforated Jejunal Diverticulitis, Mohamed Nagi MD, Stanley DeTurris MD, Ang Darwin 2020 HCA Healthcare

A Rare Case Of Perforated Jejunal Diverticulitis, Mohamed Nagi Md, Stanley Deturris Md, Ang Darwin

General Surgery

Introduction: Jejunal diverticulosis is a rare condition with clinical incidence of 0.5%. It is less common than colonic and duodenum diverticulosis. It is usually asymptomatic and diagnosed incidentally but it may cause chronic symptoms and acute complications. The aim of the case report to increase the awareness about the disease Case Report: This is a 56-year-old Caucasian male who presented with abdominal pain and fever and was diagnosed with transverse colon diverticulitis with microperforation on CT scan. Patient was treated nonoperatively with antibiotics and was discharged home. Two months later, he presented with similar recurrent abdominal pain and was ...


General Surgery Residency And Emergency General Surgery Service Reduces Readmission Rates And Length Of Stay In Non-Operative Small Bowel Obstruction, Sarah Waterman Manning MD, Katherine S. Mastriani 2020 HCA Healthcare

General Surgery Residency And Emergency General Surgery Service Reduces Readmission Rates And Length Of Stay In Non-Operative Small Bowel Obstruction, Sarah Waterman Manning Md, Katherine S. Mastriani

General Surgery

No abstract provided.


The Overall Poor Specificity Of Mrcp In The Preoperative Evaluation Of The Jaundiced Patient Will Increase The Incidence Of Non-Therapeutic Ercp, Andrew M. O'Neill MD, Keith Anderson MD, Lorinda K. Baker, Michaal Schurr MD 2020 HCA Healthcare

The Overall Poor Specificity Of Mrcp In The Preoperative Evaluation Of The Jaundiced Patient Will Increase The Incidence Of Non-Therapeutic Ercp, Andrew M. O'Neill Md, Keith Anderson Md, Lorinda K. Baker, Michaal Schurr Md

General Surgery

See additional files.


Metastatic Leiomyosarcoma Presenting As Polycystic Liver Disease, Michael Burkholz DO, Apurva Modi MD 2020 HCA Healthcare

Metastatic Leiomyosarcoma Presenting As Polycystic Liver Disease, Michael Burkholz Do, Apurva Modi Md

Gastroenterology

No abstract provided.


The Efficacy Of Peppermint Oil And Physical Activity Vs. Eluxadoline For The Treatment Of Irritable Bowel Syndrome, Julian Kang 2020 Arcadia University

The Efficacy Of Peppermint Oil And Physical Activity Vs. Eluxadoline For The Treatment Of Irritable Bowel Syndrome, Julian Kang

Capstone Showcase

Introduction: Irritable bowel syndrome (IBS), defined as a chronic functional disorder that is characterized by recurring abdominal pain and altered bowel habits, is the most commonly diagnosed gastrointestinal disease in Western populations. While not yet completely understood, IBS has multiple factors believed to contribute to its pathophysiology. There are several treatment methods regarding non-pharmacological (such as lifestyle modifications) and pharmacological options (including anti-spasmodics, opioid agonists, and anti-depressants). Peppermint oil is a product derived from the natural herb, Mentha Piperita, and has been used as a nonpharmacological method to treat abdominal pain. Therefore, this review analyzes the use of peppermint oil ...


Probiotics And The Prevention Of Clostridioides Difficile: A Review Of Existing Systematic Reviews, Andrea L. Onstad 2020 Minnesota State University, Mankato

Probiotics And The Prevention Of Clostridioides Difficile: A Review Of Existing Systematic Reviews, Andrea L. Onstad

All Theses, Dissertations, and Other Capstone Projects

Clostridioides difficile is the leading cause of infectious diarrhea (Vernaya et al., 2017). Probiotics have been proposed to provide a protective benefit against Clostridioides difficile infection (CDI). The objective of this literature review was to examine the research evidence pertaining to the use of probiotics for the prevention of CDI in individuals receiving antibiotic therapy. A systematic literature review of studies published between 2015 and 2019 was performed. Five databases were searched, which yielded 10 systematic reviews that met strict inclusion criteria. Overall, the majority of evidence indicated that probiotics versus no treatment, placebo, or usual care have the potential ...


Prevalence Of The Hypervirulent Nap1/Bi/027 Strain Of C. Difficile In Southwestern Virginia And Risk Factors Associated With Infection, Andrew O. Hanna, Anthony Baffoe-Bonnie, Shikha Vasudeva 2020 VCU Health System, Internal Medicine-Pediatrics

Prevalence Of The Hypervirulent Nap1/Bi/027 Strain Of C. Difficile In Southwestern Virginia And Risk Factors Associated With Infection, Andrew O. Hanna, Anthony Baffoe-Bonnie, Shikha Vasudeva

Graduate Medical Education (GME) Resident and Fellow Research Day Posters

C. difficile infection (CDI) incidence has increased over the last several decades. The BI/NAP1/027 ribotype was discovered in 2005 and has since been responsible for multiple outbreaks in the US and Canada. This subtype of C. Difficile is known to be more virulent in vivo and produce more severe disease. Limited regional data of the prevalence of this ribotype is available, which could help guide treatment. Using infection control data from a large regional hospital and a VA medical center, this study documented the prevalence of the 027 ribotype in Southwest Virginia. Patients were included if they were ...


Long Term Outcomes Of Surgical And Clinical Symptoms Following Minimally Invasive Heller Myotomy: A Retrospective Clinical Database Review, Laura E. Flores, Priscila Rodrigues Armijo, Bhavani Pokala, Sarah Samreen, Dmitry Oleynikov 2019 Center for Advanced Surgical Technology, University of Nebraska Medical Center

Long Term Outcomes Of Surgical And Clinical Symptoms Following Minimally Invasive Heller Myotomy: A Retrospective Clinical Database Review, Laura E. Flores, Priscila Rodrigues Armijo, Bhavani Pokala, Sarah Samreen, Dmitry Oleynikov

Graduate Medical Education Research Journal

I

Introduction

Minimally invasive Heller myotomy rates have increased, but little evidence is available regarding long term clinical and surgical outcomes. Our aim was to evaluate long term symptom improvement and medication resolution for patients undergoing minimally invasive Heller myotomy.

Methods

A single-institution database was retrospectively reviewed for patients undergoing laparoscopic Heller myotomy (LHM) or robotic Heller myotomy (RHM) during 2007-2018. Patients with primary HM followed by a Dor fundoplication were included. Demographics and surgical data were analyzed. Esophageal symptoms, testing, and medication use were collected preoperatively (pre-op), at 6-month (6-mo), 12-month (12-mo), and long-term (LT; 12-mo+) follow-up. Analysis was ...


Neighborhood Characteristics And Colorectal Cancer Survivors' Quality Of Care, Ulrike Boehmer, Jennifer Potter, Melissa A. Clark, Al Ozonoff, Rachel M. Ceballos, Michael Winter, Kevan L. Hartshorn 2019 Boston University

Neighborhood Characteristics And Colorectal Cancer Survivors' Quality Of Care, Ulrike Boehmer, Jennifer Potter, Melissa A. Clark, Al Ozonoff, Rachel M. Ceballos, Michael Winter, Kevan L. Hartshorn

Open Access Articles

Purpose: Quality cancer care entails receipt of a Survivorship Care Plan (SCP). The purpose of this study was to determine differences in SCP delivery by patient-level and neighborhood characteristics.

Methods: We obtained California cancer registry data on individuals who were diagnosed with stage I, II, or III colorectal cancer (CRC) between 2012 and 2015 and resided in predetermined geographic areas. We then mailed them a questionnaire, which queried about receipt of a SCP and its content. SCP was defined by content, as summary of cancer treatment, cancer surveillance recommendations, and/or an individualized preventive care. Using logistic regression modeling, each ...


Ramucirumab: A New Agent For Advanced Or Metastatic Gastric Junction Adenocarcinoma, Adam Smith, Rebecca Worden, Jessica Hoffert, Brendon Rasor, Hannah Stewart, David Koh 2019 Ohio Northern University

Ramucirumab: A New Agent For Advanced Or Metastatic Gastric Junction Adenocarcinoma, Adam Smith, Rebecca Worden, Jessica Hoffert, Brendon Rasor, Hannah Stewart, David Koh

Pharmacy and Wellness Review

Ramucirumab (Cyramza®), approved April 21, 2014, is a vascular endothelial growth factor receptor 2 (VEGFR2) antagonist with a U.S. Food and Drug Administration (FDA) indication for the treatment of advanced or metastatic gastric/gastroesophageal junction adenocarcinoma. Gastric cancer is a prevalent cancer in the United States with a poor prognosis. The phase 3 trial, REGARD, shows that ramucirumab, when used within four months after the last dose of first-line chemotherapy or six months after the last dose of adjuvant chemotherapy, increases overall survival. Also, ramucirumab has been included in combination therapy, such as in the RAINBOW trial, which demonstrated ...


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