Open Access. Powered by Scholars. Published by Universities.®

Musculoskeletal Diseases Commons

Open Access. Powered by Scholars. Published by Universities.®

493 Full-Text Articles 1,573 Authors 112,856 Downloads 70 Institutions

All Articles in Musculoskeletal Diseases

Faceted Search

493 full-text articles. Page 1 of 23.

Weight Reduction Motivation In Osteoarthritis Patients Through Nurse Practitioner Driven Education And Follow-Up: A Pilot Project, Caoilfhionn Mulvey, Martha Fuller PhD 2021 University of San Diego

Weight Reduction Motivation In Osteoarthritis Patients Through Nurse Practitioner Driven Education And Follow-Up: A Pilot Project, Caoilfhionn Mulvey, Martha Fuller Phd

Doctor of Nursing Practice Final Manuscripts

Purpose of Project: The ultimate goal of this short-term pilot project is for

overweight or obese osteoarthritis patients to increase their knowledge on the benefits of

weight loss and physical activity. Research shows that for every kilogram of weight lost,

2.2–4.0 kilograms of weight is taken off of the joint and could reduce joint pain up to

thirty to fifty percent and improve quality of life. Following education from the provider,

patients will understand the correlation of osteoarthritis symptom management with

weight loss.

EBP Model/Frameworks: This project utilizes the Iowa Model of Evidence-Based

Practice to Promote ...


Sarcopenia Screening By Registered Dietitian Nutritionists (Rdns) In The United States (U.S.), Madison Marcom 2021 East Tennessee State University

Sarcopenia Screening By Registered Dietitian Nutritionists (Rdns) In The United States (U.S.), Madison Marcom

Electronic Theses and Dissertations

Sarcopenia is a disease of muscle wasting primarily seen in older adults. Although this term was first coined over three decades ago, there is a lack of consensus on a definition, screening criteria, and treatment protocol for sarcopenia. The primary purpose of this study is to determine whether registered dietitian nutritionists (RDNs) in the United States (U.S.) screen for sarcopenia. Study participants were recruited through a randomized email list and included RDNs throughout the U.S. Respondents completed a survey questioning knowledge of sarcopenia, screening tools and company protocols in place, and the need and desire for sarcopenia education ...


Assessing The Patient-Perceived Monetary Value Of Patient-Reported Outcome Improvement For Patients With Chronic Knee Conditions, Sarah B. Floyd, Alicia Oostdyk, Melanie Cozad, John M. Brooks, Paul Siffri, Brian Burnikel 2021 Clemson University

Assessing The Patient-Perceived Monetary Value Of Patient-Reported Outcome Improvement For Patients With Chronic Knee Conditions, Sarah B. Floyd, Alicia Oostdyk, Melanie Cozad, John M. Brooks, Paul Siffri, Brian Burnikel

Journal of Patient-Centered Research and Reviews

Purpose: The high cost of orthopaedic care has attracted criticism in the current value-based health care environment. The objective of this work was to assess the properties of a willingness to pay (WTP)-based approach to estimate the monetary value that patients place on health improvements in chronic knee conditions following orthopaedic treatment.

Methods: A sample of patients with a chronic knee condition were surveyed between January and May of 2018 at a large orthopaedic practice. Each patient provided their WTP for restoration to ideal knee health and completed the Single Assessment Numerical Evaluation (SANE) to describe their baseline knee ...


Osteogenesis Imperfecta, Dustin Kim 2021 Southern Adventist University

Osteogenesis Imperfecta, Dustin Kim

Campus Research Day

Osteogenesis Imperfecta is an inherited disease that has varying stages of severity. The effects of this disease results in a person's bones becoming brittle and weak to where it can easily fracture or completely break. Though this disease is similar to other bone-deteriorating diseases, like osteoporosis, osteogenesis imperfecta begins with a person having abnormalities in the genes that produce collagen in bones. Collagen is an important component of bone, keeping it strong and resilient against injuries. Yet, those genes end up shutting off, and the victim begins to lack collagen in their bones, making their bones susceptible to breaking.


Trunk Kinematics Using Musculoskeletal Modeling During Range Of Motion Tasks, Maryam Moeini, Ruth M. Higgins, Hunter Bennett, Stacie Ringleb 2021 Old Dominion University

Trunk Kinematics Using Musculoskeletal Modeling During Range Of Motion Tasks, Maryam Moeini, Ruth M. Higgins, Hunter Bennett, Stacie Ringleb

College of Health Sciences Posters

A spine model can be used to predict post-spinal fusion motion needed to perform physical activities in individuals with scoliosis. Full body lumbar spine (FBLS) model (Raabi et al., 2016) allows for modeling lumbar spine and pelvis movement and was validated for jogging. However, like other existing adult spine models, FBLS model does not allow for a motion providing thoracic and spine. Purpose: To adapt the FBLS model for simulating thoracic, lumbar and pelvis motion during trunk rotation in all 3 planes of motion. Methods: Since T12-L1 in FBLS model is designed as a dependent joint (axial rotation analogous to ...


Automatic Generation And Novel Validation Of Patient-Specific, Anatomically Inclusive Scoliosis Models For Biomechanics-Informed Surgical Planning, Austin Tapp, Michel Audette, James Bennett 2021 Old Dominion University

Automatic Generation And Novel Validation Of Patient-Specific, Anatomically Inclusive Scoliosis Models For Biomechanics-Informed Surgical Planning, Austin Tapp, Michel Audette, James Bennett

College of Engineering & Technology (Batten) Posters

Scoliosis is an abnormal spinal curvature of greater than 10 degrees. Severe scoliotic deformities are addressed with highly invasive procedures: anterior or posterior spinal fusion approaches. This invasiveness is due, in part, to the constraints of current surgical planning, which utilizes computed tomography (CT) scans unable to discern spinal ligaments that are dissected to make the spine sufficiently compliant for correction. If localization of ligaments and soft tissues were achieved pre-operatively, corrective procedures could become safer and more efficient by using finite element (FE) biomechanical simulations to determine decreased incidences of ligament releases. This research aims to achieve ligament localization ...


Efficacy And Safety Of Biosimilar Ct-P17 Versus Reference Adalimumab In Subjects With Rheumatoid Arthritis: 24-Week Results From A Randomized Study, Jonathan Kay, Edward Keystone 2021 University of Massachusetts Medical School

Efficacy And Safety Of Biosimilar Ct-P17 Versus Reference Adalimumab In Subjects With Rheumatoid Arthritis: 24-Week Results From A Randomized Study, Jonathan Kay, Edward Keystone

Open Access Publications by UMMS Authors

BACKGROUND: To demonstrate equivalent efficacy of the proposed high-concentration (100 mg/ml), citrate-free adalimumab biosimilar CT-P17 to European Union-approved adalimumab (EU-adalimumab) in subjects with active rheumatoid arthritis (RA).

METHODS: This randomized, double-blind phase III study ( ClinicalTrials.gov , NCT03789292) randomized (1:1) subjects with active RA at 52 centers to receive CT-P17 or EU-adalimumab 40 mg subcutaneously every 2 weeks until week 52. Results to week 24 are reported here. The primary endpoint was 20% improvement by American College of Rheumatology criteria (ACR20) response rate at week 24. Equivalence was concluded if the corresponding confidence intervals (CIs) for the estimate of ...


Filgotinib In Combination With Methotrexate Or As Monotherapy Versus Methotrexate Monotherapy In Patients With Active Rheumatoid Arthritis And Limited Or No Prior Exposure To Methotrexate: The Phase 3, Randomised Controlled Finch 3 Trial, Rene Westhovens, Jonathan Kay 2021 Catholic University of Leuven

Filgotinib In Combination With Methotrexate Or As Monotherapy Versus Methotrexate Monotherapy In Patients With Active Rheumatoid Arthritis And Limited Or No Prior Exposure To Methotrexate: The Phase 3, Randomised Controlled Finch 3 Trial, Rene Westhovens, Jonathan Kay

Open Access Publications by UMMS Authors

OBJECTIVES: To investigate efficacy and safety of the Janus kinase-1 inhibitor filgotinib in patients with active rheumatoid arthritis (RA) with limited or no prior methotrexate (MTX) exposure.

METHODS: This 52-week, phase 3, multicentre, double-blind clinical trial (NCT02886728) evaluated once-daily oral filgotinib in 1252 patients with RA randomised 2:1:1:2 to filgotinib 200 mg with MTX (FIL200 +MTX), filgotinib 100 mg with MTX (FIL100 +MTX), filgotinib 200 mg monotherapy (FIL200), or MTX. The primary endpoint was proportion achieving 20% improvement in American College of Rheumatology criteria (ACR20) at week 24.

RESULTS: The primary endpoint was achieved by 81% of ...


A 5-Year Clinical Follow-Up Study From The Italian National Registry For Fshd, Liliana Vercelli, Louise Maranda, Tiziana Mongini, Rossella Ginevra Tupler 2021 University of Turin

A 5-Year Clinical Follow-Up Study From The Italian National Registry For Fshd, Liliana Vercelli, Louise Maranda, Tiziana Mongini, Rossella Ginevra Tupler

Open Access Publications by UMMS Authors

BACKGROUND: The natural history of facioscapulohumeral muscular dystrophy (FSHD) is undefined.

METHODS: An observational cohort study was conducted in 246 FSHD1 patients. We split the analysis between index cases and carrier relatives and we classified all patients using the Comprehensive Clinical Evaluation Form (CCEF). The disease progression was measured as a variation of the FSHD score performed at baseline and at the end of 5-year follow-up (DeltaFSHD score).

FINDINGS: Disease worsened in 79.4% (112/141) of index cases versus 38.1% (40/105) of carrier relatives and advanced more rapidly in index cases (DeltaFSHD score 2.3 versus 1 ...


Screening, Brief Intervention, And Referral To Treatment For Pain Management For Veterans Seeking Service-Connection Payments For Musculoskeletal Disorders: Sbirt-Pm Study Protocol, Steve Martino, Christina Lazar, John Sellinger, Kathryn Gilstad-Hayden, Brenda Fenton, Paul G. Barnett, Brad R. Brummett, Diana M. Higgins, Paul Holtzheimer, Kristin M. Mattocks, Tu Ngo, Thomas E. Reznik, Alicia M. Semiatin, Todd Stapley, Marc I. Rosen 2020 Yale University

Screening, Brief Intervention, And Referral To Treatment For Pain Management For Veterans Seeking Service-Connection Payments For Musculoskeletal Disorders: Sbirt-Pm Study Protocol, Steve Martino, Christina Lazar, John Sellinger, Kathryn Gilstad-Hayden, Brenda Fenton, Paul G. Barnett, Brad R. Brummett, Diana M. Higgins, Paul Holtzheimer, Kristin M. Mattocks, Tu Ngo, Thomas E. Reznik, Alicia M. Semiatin, Todd Stapley, Marc I. Rosen

COVID-19 Publications by UMMS Authors

BACKGROUND: Veterans with significant chronic pain from musculoskeletal disorders are at risk of substance misuse. Veterans whose condition is the result of military service may be eligible for a disability pension. Department of Veterans Affairs compensation examinations, which determine the degree of disability and whether it was connected to military service, represent an opportunity to engage Veterans in pain management and substance use treatments. A multisite randomized clinical trial is testing the effectiveness and cost-effectiveness of Screening, Brief Intervention, and Referral to Treatment for Pain Management (SBIRT-PM) for Veterans seeking compensation for musculoskeletal disorders. This telephone-based intervention is delivered through ...


Large Genotype-Phenotype Study In Carriers Of D4z4 Borderline Alleles Provides Guidance For Facioscapulohumeral Muscular Dystrophy Diagnosis, Giulia Ricci, Rossella Ginevra Tupler 2020 University of Modena and Reggio Emilia

Large Genotype-Phenotype Study In Carriers Of D4z4 Borderline Alleles Provides Guidance For Facioscapulohumeral Muscular Dystrophy Diagnosis, Giulia Ricci, Rossella Ginevra Tupler

Open Access Publications by UMMS Authors

Facioscapulohumeral muscular dystrophy (FSHD) is a myopathy with prevalence of 1 in 20,000. Almost all patients affected by FSHD carry deletions of an integral number of tandem 3.3 kilobase repeats, termed D4Z4, located on chromosome 4q35. Assessment of size of D4Z4 alleles is commonly used for FSHD diagnosis. However, the extended molecular testing has expanded the spectrum of clinical phenotypes. In particular, D4Z4 alleles with 9-10 repeat have been found in healthy individuals, in subjects with FSHD or affected by other myopathies. These findings weakened the strict relationship between observed phenotypes and their underlying genotypes, complicating the interpretation ...


Multi-Digit Auto-Amputation In Setting Of Mixed Connective Tissue Disease, Kishan P. Patel, Jennifer L. Medlin, Michelene Hearth-Holmes 2020 University of Nebraska Medical Center

Multi-Digit Auto-Amputation In Setting Of Mixed Connective Tissue Disease, Kishan P. Patel, Jennifer L. Medlin, Michelene Hearth-Holmes

Graduate Medical Education Research Journal

Raynaud’s disease is a cutaneous manifestation often present in various connective tissue and vascular diseases. Depending on the age of onset and acuity of symptoms, the phenomenon can provide clinicians with some insight as to the severity of underlying disease, including the distinction between primary and secondary Raynaud’s. However, this diagnostic approach seems to have its limitations regarding efficacy and timing of treatment. Traditionally, treatment of Raynaud’s has focused on reestablishing blood perfusion to affected tissue, which has previously been achieved with vasodilatory medications and site-specific surgical intervention. In lieu of the severe sequelae of Raynaud’s ...


The Physiological Interaction Of Sleep Deprivation And Zoledronate On Distal Femur Trabecular Thickness Of Ovariectomized Rats, Erin Nolte, Frank Frisch, Oliver Lopez 2020 Chapman University

The Physiological Interaction Of Sleep Deprivation And Zoledronate On Distal Femur Trabecular Thickness Of Ovariectomized Rats, Erin Nolte, Frank Frisch, Oliver Lopez

Health Sciences and Kinesiology Faculty Articles

Osteoporosis, a disease resulting in an increased risk of fracture due to compromised bone, affects 1 in 3 postmenopausal women. Discontinuities in the microarchitecture of bone, such as trabeculae, are seen in postmenopausal osteoporosis. This study aimed to evaluate how sleep deprivation affects the distal femur trabecular thickness of estrogen-deficient rats treated with Zoledronate. 29 ovariectomized Wistar female rats were separated into 4 groups. The control group (C) was housed in standard housing with a 12-hour light/dark cycle and was given an intravenous injection of 0.45 mL of 0.9% saline. The Zoledronate group (Z) were also housed ...


Cost-Effectiveness Of Screening For Osteoporosis In Older Men With A History Of Falls, Kouta Ito 2020 University of Massachusetts Medical School

Cost-Effectiveness Of Screening For Osteoporosis In Older Men With A History Of Falls, Kouta Ito

Open Access Publications by UMMS Authors

Importance: Falls and osteoporosis share the potential clinical end point of fractures among older patients. To date, few fall prevention guidelines incorporate screening for osteoporosis to reduce fall-related fractures.

Objective: To assess the cost-effectiveness of screening for osteoporosis using dual-energy x-ray absorptiometry (DXA) followed by osteoporosis treatment in older men with a history of falls.

Design, Setting, and Participants: In this economic evaluation, a Markov model was developed to simulate the incidence of major osteoporotic fractures in a hypothetical cohort of community-dwelling men aged 65 years who had fallen at least once in the past year. Data sources included literature ...


A Functional Three-Dimensional Microphysiological Model Of Myeloma Bone Disease, Richard Visconti 2020 Seton Hall University

A Functional Three-Dimensional Microphysiological Model Of Myeloma Bone Disease, Richard Visconti

Seton Hall University Dissertations and Theses (ETDs)

Multiple myeloma (MM) is a hematologic cancer caused by a mature B cell neoplasm, or plasmacytoma, that infiltrates the skeleton at several sites. The disease is characterized by uninhibited transformed plasma cell proliferation that disrupts skeletal homeostasis leading to decreased bone modeling and increased bone resorption. Osteolytic lesions (OL) or voids left in the bone, remain long after the treatment of the cancer and indicate disease progression to myeloma bone disease (MBD). Current combinatorial MM therapies inhibit malignant plasma cell proliferation, slow the progression towards MBD, and increase the mean five-year survival rate, but do little to improve osteoblastic function ...


Does An Empathic Pre-Visit Conversation With Another Team Member Improve Perceived Surgeon Empathy?, Lindy Derkzen, Janna S E Ottenhoff, Carrie Barron, David Ring 2020 Dell Medical School, University of Texas at Austin

Does An Empathic Pre-Visit Conversation With Another Team Member Improve Perceived Surgeon Empathy?, Lindy Derkzen, Janna S E Ottenhoff, Carrie Barron, David Ring

Patient Experience Journal

Orthopedic surgeon specialists can help alleviate symptoms and reduce self-reported activity limitations by addressing stress, distress, and unhelpful cognitive biases regarding pain (e.g., “hurt equals harm”). But noticing mental and social health opportunities in specialty care can harm the patient-surgeon relationship. This study evaluated the ability of an empathic pre-visit conversation by another team member to improve the patient-surgeon relationship measured as perceived empathy. Factors associated with pain intensity, magnitude of self-reported activity limitations, symptoms of depression, and satisfaction with the surgeon were also studied. We enrolled 100 patients visiting an orthopedic surgeon for the first time. Prior to ...


Mekk2 Mediates Aberrant Erk Activation In Neurofibromatosis Type I, Seoyeon Bok, Dong Yeon Shin, Alisha R. Yallowitz, Mark Eiseman, Michelle Cung, Ren Xu, Na Li, Jun Sun, Alfred L. Williams, John E. Scott, Bing Su, Jae-Hyuck Shim, Matthew B. Greenblatt 2020 Weill Cornell Medicine

Mekk2 Mediates Aberrant Erk Activation In Neurofibromatosis Type I, Seoyeon Bok, Dong Yeon Shin, Alisha R. Yallowitz, Mark Eiseman, Michelle Cung, Ren Xu, Na Li, Jun Sun, Alfred L. Williams, John E. Scott, Bing Su, Jae-Hyuck Shim, Matthew B. Greenblatt

Open Access Publications by UMMS Authors

Neurofibromatosis type I (NF1) is characterized by prominent skeletal manifestations caused by NF1 loss. While inhibitors of the ERK activating kinases MEK1/2 are promising as a means to treat NF1, the broad blockade of the ERK pathway produced by this strategy is potentially associated with therapy limiting toxicities. Here, we have sought targets offering a more narrow inhibition of ERK activation downstream of NF1 loss in the skeleton, finding that MEKK2 is a novel component of a noncanonical ERK pathway in osteoblasts that mediates aberrant ERK activation after NF1 loss. Accordingly, despite mice with conditional deletion of Nf1 in ...


Hydroxychloroquine And The Risk Of Respiratory Infections Among Ra Patients, Joel M. Kremer, George W. Reed, Dimitrios A. Pappas, Leslie R. Harrold, Kevin J. Kane, Jeffrey Greenberg, Kevin Winthrop 2020 Albany Medical College

Hydroxychloroquine And The Risk Of Respiratory Infections Among Ra Patients, Joel M. Kremer, George W. Reed, Dimitrios A. Pappas, Leslie R. Harrold, Kevin J. Kane, Jeffrey Greenberg, Kevin Winthrop

Open Access Publications by UMMS Authors

OBJECTIVES: To determine the effect of hydroxychloroquine on the incidence of new respiratory infections in a large registry of rheumatoid arthritis (RA) patients compared with a matched cohort receiving other conventional disease-modifying antirheumatic drugs (csDMARDs).

METHODS: We reviewed physician-reported infections including upper respiratory infections (URI), bronchitis and pneumonia in the Corrona RA registry from June 2008 to February 2020 with the goal of comparing infections in biologic/targeted synthetic (b/ts) DMARDs naive HCQ starts compared with starts of other csDMARDs and no HCQ. Patients on different interventions were compared using time-varying adjusted Cox models adjusting for age, sex, duration ...


Two Cases Of Acute Anterolateral Compartment Syndrome Following Inversion Ankle Injuries, Jugert Bango, Evan Zhang, Daniel Aaron, Amna Diwan 2020 University of Massachusetts Medical School

Two Cases Of Acute Anterolateral Compartment Syndrome Following Inversion Ankle Injuries, Jugert Bango, Evan Zhang, Daniel Aaron, Amna Diwan

Open Access Publications by UMMS Authors

Introduction: Compartment syndrome is a limb threatening, and sometimes life-threatening medical condition. It usually occurs in high energy lower extremity injuries, commonly in the younger patient with classic signs and symptoms. Pain out of proportion to exam is one of the key elements in diagnosis. A high vigilance for signs and symptoms of this condition should be present on most physicians' radars who treat emergency conditions, as this case report demonstrates, the mechanism and story are not always classic.

Presentation of cases: Two cases of young, healthy adults who underwent fasciotomy for compartment release for compartment syndrome isolated to the ...


Two Cases Of Acute Anterolateral Compartment Syndrome Following Inversion Ankle Injuries, Jugert Bango, Evan Zhang, Daniel L. Aaron, Amna Diwan 2020 University of Massachusetts Medical School

Two Cases Of Acute Anterolateral Compartment Syndrome Following Inversion Ankle Injuries, Jugert Bango, Evan Zhang, Daniel L. Aaron, Amna Diwan

University of Massachusetts Medical School Faculty Publications

Introduction: Compartment syndrome is a limb threatening, and sometimes life-threatening medical condition. It usually occurs in high energy lower extremity injuries, commonly in the younger patient with classic signs and symptoms. Pain out of proportion to exam is one of the key elements in diagnosis. A high vigilance for signs and symptoms of this condition should be present on most physicians' radars who treat emergency conditions, as this case report demonstrates, the mechanism and story are not always classic.

Presentation of cases: Two cases of young, healthy adults who underwent fasciotomy for compartment release for compartment syndrome isolated to the ...


Digital Commons powered by bepress