Open Access. Powered by Scholars. Published by Universities.®

Musculoskeletal Diseases Commons

Open Access. Powered by Scholars. Published by Universities.®

380 Full-Text Articles 1,119 Authors 52,246 Downloads 52 Institutions

All Articles in Musculoskeletal Diseases

Faceted Search

380 full-text articles. Page 1 of 17.

Immunosuppressive Treatment And The Risk Of Diabetes In Rheumatoid Arthritis, Siri Lillegraven, Jeffrey D. Greenberg, George W. Reed, Katherine Saunders, Jeffrey R. Curtis, Leslie R. Harrold, Marc C. Hochberg, Dimitrios A. Pappas, Joel M. Kremer, Daniel H. Solomon 2019 Diakonhjemmet Hospital

Immunosuppressive Treatment And The Risk Of Diabetes In Rheumatoid Arthritis, Siri Lillegraven, Jeffrey D. Greenberg, George W. Reed, Katherine Saunders, Jeffrey R. Curtis, Leslie R. Harrold, Marc C. Hochberg, Dimitrios A. Pappas, Joel M. Kremer, Daniel H. Solomon

Leslie R. Harrold

OBJECTIVE: Inflammation and anti-inflammatory treatments might influence the risk of diabetes. The objective of this study was to assess factors associated with incident diabetes in rheumatoid arthritis (RA).

METHODS: The study population consisted of RA patients from a multi-center cohort study, Corrona. To assess risk associated with disease modifying antirheumatic drug (DMARD) exposure, we assessed five mutually exclusive DMARD groups. Additionally, we assessed the risk associated with body mass index (BMI, < 25, 25-30, > 30 kg/m2) and glucocorticoid usage. Incident cases of diabetes were confirmed through adjudication, and Cox regression models were fit to estimate the risk of incident diabetes.

RESULTS: We ...


Diabetic Neuropathic Foot Without Neuropathy: Could It Be Cancer? - A Case Report, Jennifer Baima, Felix Santiago, Mathew J. Most 2019 University of Massachusetts Medical School

Diabetic Neuropathic Foot Without Neuropathy: Could It Be Cancer? - A Case Report, Jennifer Baima, Felix Santiago, Mathew J. Most

Orthopedics and Physical Rehabilitation Publications and Presentations

We present a case of a 64 year-old diabetic male who presented with months of progressively worsening foot pain and swelling, who was initially diagnosed with Charcot joint disease.(CJD) He was ultimately found to have a very rare tumor.


The Role Of Curcumin In Inflammatory Pathogenesis And The Benefits In Treatment Of Osteoarthritis, Alena V. Moreno 2019 University of Lynchburg

The Role Of Curcumin In Inflammatory Pathogenesis And The Benefits In Treatment Of Osteoarthritis, Alena V. Moreno

Lynchburg Journal of Medical Science

Curcumin is a perennial herb that originated in India, and its scientific name is Curcuma longa that belongs to the Zingiberaceae family. The active ingredients in turmeric are demethoxycurcumin, bisdemethoxycurcumin, and the particularly important compound is curcumin polyphenols. Curcumin has been recognized as a polyphenolic compound that has antioxidant, anti-inflammatory, anti-tumor, anti-diabetic, immunomodulatory and anti-depressant abilities, and may counteract underlying cellular mechanisms which that frequently lead to oxidative stress and inflammation that plays a significant part in OA pathogenesis. The main factors responsible for cartilage degeneration are interleukin- one (IL-1) and tumor necrosis factor-alpha (TNF-alpha).13 These factors are responsible ...


Immunosuppressive Treatment And The Risk Of Diabetes In Rheumatoid Arthritis, Siri Lillegraven, Jeffrey D. Greenberg, George W. Reed, Katherine Saunders, Jeffrey R. Curtis, Leslie R. Harrold, Marc C. Hochberg, Dimitrios A. Pappas, Joel M. Kremer, Daniel H. Solomon 2019 Diakonhjemmet Hospital

Immunosuppressive Treatment And The Risk Of Diabetes In Rheumatoid Arthritis, Siri Lillegraven, Jeffrey D. Greenberg, George W. Reed, Katherine Saunders, Jeffrey R. Curtis, Leslie R. Harrold, Marc C. Hochberg, Dimitrios A. Pappas, Joel M. Kremer, Daniel H. Solomon

Open Access Articles

OBJECTIVE: Inflammation and anti-inflammatory treatments might influence the risk of diabetes. The objective of this study was to assess factors associated with incident diabetes in rheumatoid arthritis (RA).

METHODS: The study population consisted of RA patients from a multi-center cohort study, Corrona. To assess risk associated with disease modifying antirheumatic drug (DMARD) exposure, we assessed five mutually exclusive DMARD groups. Additionally, we assessed the risk associated with body mass index (BMI, < 25, 25-30, > 30 kg/m2) and glucocorticoid usage. Incident cases of diabetes were confirmed through adjudication, and Cox regression models were fit to estimate the risk of incident diabetes.

RESULTS: We ...


Real-World Comparative Effectiveness Of Tocilizumab Monotherapy Vs. Tumor Necrosis Factor Inhibitors With Methotrexate In Patients With Rheumatoid Arthritis, Leslie R. Harrold, George W. Reed, Jennie Best, Steve Zlotnick, Joel M. Kremer 2018 University of Massachusetts Medical School

Real-World Comparative Effectiveness Of Tocilizumab Monotherapy Vs. Tumor Necrosis Factor Inhibitors With Methotrexate In Patients With Rheumatoid Arthritis, Leslie R. Harrold, George W. Reed, Jennie Best, Steve Zlotnick, Joel M. Kremer

Open Access Articles

INTRODUCTION: Controlled clinical studies have shown that the efficacy of tocilizumab (TCZ) monotherapy is superior to that of tumor necrosis factor inhibitor (TNFi) monotherapy and comparable to that of TCZ plus methotrexate (MTX) for the treatment of rheumatoid arthritis (RA). This study compared the real-world effectiveness of TCZ monotherapy vs. TNFis plus MTX in US patients with RA.

METHODS: TCZ-naive patients from the Corrona RA registry with prior exposure to > /= 1 TNFi who initiated TCZ monotherapy or TNFi + MTX were included. Outcomes included mean change in Clinical Disease Activity Index (CDAI), achievement of low disease activity (LDA; CDAI < /= 10), achievement of modified American College of Rheumatology (mACR) 20/50 responses, and mean change in modified Health Assessment Questionnaire (mHAQ) at 6 months. Patients initiating TNFi + MTX were grouped by MTX dose ( < /= 10 mg; > 10 to ...


Wrist Arthritis, Hossein Akhondi, Sreelakshmi Panginikkod 2018 University of Nevada

Wrist Arthritis, Hossein Akhondi, Sreelakshmi Panginikkod

Open Access Articles

Arthritis means inflammation of the joint. Symptoms of arthritis includes pain, swelling, redness, stiffness and loss of motion of the involved joint. Wrist arthritis can affect multiple functions of daily life and hence acknowledging its causes, seeking proper diagnosis, and finding effective long-term treatments are necessary to avoid disability.


Dermatomyositis And Polymyositis, Apoorva Cheeti, Sreelakshmi Panginikkod 2018 Kamineni Institute of Medical Sciences

Dermatomyositis And Polymyositis, Apoorva Cheeti, Sreelakshmi Panginikkod

Open Access Articles

Idiopathic inflammatory myositis (IIM) is classified into 4 subtypes based on clinical and histopathological features. Polymyositis and dermatomyositis (PM/DM) are 2 of those subtypes in addition to immune-mediated necrotizing myopathy and inclusion body myositis. The presence of autoantibodies and inflammatory infiltration in the muscles suggests that idiopathic inflammatory myositis is an autoimmune condition, but the target autoantigens have not yet been identified. Apart from symmetric proximal muscle weakness, polymyositis and dermatomyositis have several clinical manifestations in common when compared to inclusion body myositis and necrotizing myopathy and can be grouped for discussion. The most commonly used criteria for PM ...


The Chapman Bone Algorithm: A Diagnostic Alternative For The Evaluation Of Osteoporosis, Elise Levesque, Anton Ketterer, Wajiha Memon, Cameron James, Noah Barrett, Cyril Rakovski, Frank Frisch 2018 Chapman University

The Chapman Bone Algorithm: A Diagnostic Alternative For The Evaluation Of Osteoporosis, Elise Levesque, Anton Ketterer, Wajiha Memon, Cameron James, Noah Barrett, Cyril Rakovski, Frank Frisch

Mathematics, Physics, and Computer Science Faculty Articles and Research

Osteoporosis is the most common metabolic bone disease and goes largely undiagnosed throughout the world, due to the inaccessibility of DXA machines. Multivariate analyses of serum bone turnover markers were evaluated in 226 Orange County, California, residents with the intent to determine if serum osteocalcin and serum pyridinoline cross-links could be used to detect the onset of osteoporosis as effectively as a DXA scan. Descriptive analyses of the demographic and lab characteristics of the participants were performed through frequency, means and standard deviation estimations. We implemented logistic regression modeling to find the best classification algorithm for osteoporosis. All calculations and ...


A Malignant Hyperthermia Competency Training For Nurse Anesthesia Trainees: Development, Implementation, And Evaluation, Andrew Christ 2018 DePaul University

A Malignant Hyperthermia Competency Training For Nurse Anesthesia Trainees: Development, Implementation, And Evaluation, Andrew Christ

Grace Peterson Nursing Research Colloquium

A Malignant Hyperthermia Competency Training for Nurse Anesthesia Trainees: Development, Implementation, and Evaluation

Andrew Christ, RN, BSN, DNP Candidate

Faculty: Karen Kapanke, CRNA, DNP

Background: Video simulation is an alternative method of teaching that can play an important role in nurse anesthesia education. Using video simulation for uncommon crisis could prove beneficial.

Objectives: The purpose of this study is to analyze the effects of an educational video simulation regarding malignant hyperthermia (MH) recognition and management on knowledge of nurse anesthesia trainees (NATs).

Methods: A single group pretest-posttest design was used to compare knowledge on recognition and management of malignant hyperthermia ...


Methods For High-Dimensonal Analysis Of Cells Dissociated From Cyropreserved Synovial Tissue, Laura T. Donlin, Ellen M. Gravallese, Jennifer H. Anolik 2018 Weill Cornell Medical College

Methods For High-Dimensonal Analysis Of Cells Dissociated From Cyropreserved Synovial Tissue, Laura T. Donlin, Ellen M. Gravallese, Jennifer H. Anolik

Open Access Articles

BACKGROUND: Detailed molecular analyses of cells from rheumatoid arthritis (RA) synovium hold promise in identifying cellular phenotypes that drive tissue pathology and joint damage. The Accelerating Medicines Partnership RA/SLE Network aims to deconstruct autoimmune pathology by examining cells within target tissues through multiple high-dimensional assays. Robust standardized protocols need to be developed before cellular phenotypes at a single cell level can be effectively compared across patient samples.

METHODS: Multiple clinical sites collected cryopreserved synovial tissue fragments from arthroplasty and synovial biopsy in a 10% DMSO solution. Mechanical and enzymatic dissociation parameters were optimized for viable cell extraction and surface ...


Therapeutic Benefit Of Apremilast On Enthesitis And Dactylitis In Patients With Psoriatic Arthritis: A Pooled Analysis Of The Palace 1-3 Studies, Dafna D. Gladman, Arthur Kavanaugh, Juan J. Gomez-Reino, Jurgen Wollenhaupt, Maurizio Cutolo, Georg Schett, Eric Lespessailles, Benoit Guerette, Nikolay Delev, Lichen Teng, Christopher J. Edwards, Charles Birbara, Philip J. Mease 2018 Toronto Western Hospital

Therapeutic Benefit Of Apremilast On Enthesitis And Dactylitis In Patients With Psoriatic Arthritis: A Pooled Analysis Of The Palace 1-3 Studies, Dafna D. Gladman, Arthur Kavanaugh, Juan J. Gomez-Reino, Jurgen Wollenhaupt, Maurizio Cutolo, Georg Schett, Eric Lespessailles, Benoit Guerette, Nikolay Delev, Lichen Teng, Christopher J. Edwards, Charles Birbara, Philip J. Mease

Open Access Articles

Objective: The Psoriatic Arthritis Long-term Assessment of Clinical Efficacy (PALACE) clinical trial programme findings demonstrated that apremilast, an oral phosphodiesterase 4 inhibitor, is effective for treating psoriatic arthritis (PsA). Enthesitis and dactylitis are difficult-to-treat features of PsA leading to disability and affecting quality of life. PALACE 1, 2 and 3 data were pooled to assess the efficacy of apremilast on enthesitis and dactylitis outcomes in patients with these conditions at baseline.

Methods: Patients with enthesitis (n=945) or dactylitis (n=633) at baseline were analysed after receiving double-blind treatment with placebo, apremilast 30 mg two times per day or apremilast ...


The Development Of A Temporomandibular Force Simulator To Study Craniofacial Strain In-Vitro, Kenneth KC Ip 2018 The University of Western Ontario

The Development Of A Temporomandibular Force Simulator To Study Craniofacial Strain In-Vitro, Kenneth Kc Ip

Electronic Thesis and Dissertation Repository

An in-vitro musculoskeletal loading simulator was developed to replicate the internal forces of mastication, and then employed in a comparison of clinically relevant facial fracture repairs. Muscle forces are simulated by pneumatic pistons via 3D printed mounts that are reverse-engineered from CT scan to match muscle attachment sites, which are adhered to bone in order to simulate native stress distributions. Bite force and bone strain pattern of the craniofacial structure under load were measured using a force sensor and strain gauges respectively. In a series of five fresh-frozen cadaveric heads, it was found that strain patterns of the craniofacial structure ...


Fracture Liaison Services Improve Outcomes Of Patients With Osteoporosis-Related Fractures: A Systematic Literature Review And Meta-Analysis, Chih-Hsing Wu, Shih-Te Tu, Yin-Fan Chang, Ding-Cheng Chan, Jui-Teng Chien, Chih-Hsueh Lin, Sonal Singh, Manikanta Dasari, Jung-Fu Chen, Keh-Sung Tsai 2018 National Cheng Kung University

Fracture Liaison Services Improve Outcomes Of Patients With Osteoporosis-Related Fractures: A Systematic Literature Review And Meta-Analysis, Chih-Hsing Wu, Shih-Te Tu, Yin-Fan Chang, Ding-Cheng Chan, Jui-Teng Chien, Chih-Hsueh Lin, Sonal Singh, Manikanta Dasari, Jung-Fu Chen, Keh-Sung Tsai

Open Access Articles

OBJECTIVES: This systematic review and meta-analysis evaluated the outcomes of patients with osteoporosis-related fractures managed through fracture liaison services (FLS) programs.

METHODS: Medline, PubMed, EMBASE, and the Cochrane Library were searched (January 2000-February 2017 inclusive) using the keywords 'osteoporosis', 'fractures', 'liaison', and 'service' to identify randomised controlled trials and observational studies of patients aged > /=50years with osteoporosis-related fractures in hospital, clinic, community, or home-based settings who were managed using FLS. Risk of bias was assessed at outcome level. Meta-analysis followed a random-effects and fixed-effects model. Outcomes of interest were incidence of bone mineral density (BMD) testing, treatment initiation, adherence, re-fractures ...


Melatonin-Micronutrients Osteopenia Treatment Study (Mots): A Translational Study Assessing The Effects Of Melatonin, Strontium Citrate, Vitamin D3 And Vitamin K2 On Bone Density, Bone Turnover Markers And Health-Related Quality Of Life In Postmenopausal Osteopenic Women Following A One-Year Double-Blind Randomized Placebo-Controlled Trial And On Osteoblast-Osteoclast Co-Cultures, Sifat Maria 2018 Duquesne University

Melatonin-Micronutrients Osteopenia Treatment Study (Mots): A Translational Study Assessing The Effects Of Melatonin, Strontium Citrate, Vitamin D3 And Vitamin K2 On Bone Density, Bone Turnover Markers And Health-Related Quality Of Life In Postmenopausal Osteopenic Women Following A One-Year Double-Blind Randomized Placebo-Controlled Trial And On Osteoblast-Osteoclast Co-Cultures, Sifat Maria

Electronic Theses and Dissertations

Objective: The purpose of this study was to assess if a novel combination of melatonin and three other natural bone-aiding micronutrients: strontium citrate, vitamins D3 and K2 (MSDK) could improve bone health by modulating the activity of osteoblasts and osteoclasts in favor of balanced bone remodeling and by improving the overall health-related quality of life in postmenopausal osteopenic women.

Methods: The Melatonin-micronutrients Osteopenia Treatment Study (MOTS) is a translational research study that used both clinical and in vitro approaches to assess the efficacy of MSDK on bone health in women and to identify potential mechanisms for its effects ...


Transition Of Care For The Young Adult With Cleft Palate: Stuck Between Goodbye To The Pediatric Team And Hello To Adult-Centered Care, Linda Vallino, Brenda Louw 2018 Craniofacial Outcomes Research Laboratory Nemours/A.I. duPont Hospital for Children

Transition Of Care For The Young Adult With Cleft Palate: Stuck Between Goodbye To The Pediatric Team And Hello To Adult-Centered Care, Linda Vallino, Brenda Louw

ETSU Faculty Works

Participants will be able to:

  • Describe the characteristics and needs of young adults with CLP.
  • Discuss the model of transition of care for the young adult with CLP.
  • Extrapolate strategies that teams could use to improve the care of young adults with CLP.


A New Perspective On The Outcomes Of Children With Cleft Lip And Palate: Application Of The Icf-Cy, Brenda Louw 2018 East Tennessee State University

A New Perspective On The Outcomes Of Children With Cleft Lip And Palate: Application Of The Icf-Cy, Brenda Louw

ETSU Faculty Works

Learner Outcomes:

  • Acknowledge the application value of the ICF to individuals with CLP.
  • Integrate the ICF framework into the assessment of individuals with CLP.
  • Formulate intervention goals that go beyond speech production skills to include functional communication outcomes in a variety of life situations.
  • Include improvement and changes in communication participation in everyday functioning in assessment and progress reports.


Comparison Of Osteoporosis Knowledge, Beliefs, Attitudes, And Behavior Among College Students Of Various Racial/Ethnic Groups, Lauri J. DeRuiter-Willems 2018 Eastern Illinois University

Comparison Of Osteoporosis Knowledge, Beliefs, Attitudes, And Behavior Among College Students Of Various Racial/Ethnic Groups, Lauri J. Deruiter-Willems

Lauri J. DeRuiter-Willems

Osteoporosis is known as a pediatric disease with geriatric consequences. The need for
bone health, awareness of controllable risk factors and prevention of osteoporosis begins during
one’s youth (Campbell, 2012; Cannada, 2016; Evenson & Sanders, 2016; Edmonds, Turner, &
Usdan, 2012; Ford et al., 2011; Gammage et al., 2009; Gammage et al., 2012). Currently, most
health information and health campaigns focus on older adults. To promote measurable
improvements in reducing the number of cases of osteoporosis, the focus for change needs to
start as early as teenage and young adult age. In addition to the general population trends, rates
specifically associated ...


A Web-Based Treatment Decision Support Tool For Patients With Advanced Knee Arthritis: Evaluation Of User Interface And Content Design, Hua Zheng, Milagros C. Rosal, Wenjun Li, Amy Borg, Wenyun Yang, David C. Ayers, Patricia D. Franklin 2018 University of Massachusetts Medical School

A Web-Based Treatment Decision Support Tool For Patients With Advanced Knee Arthritis: Evaluation Of User Interface And Content Design, Hua Zheng, Milagros C. Rosal, Wenjun Li, Amy Borg, Wenyun Yang, David C. Ayers, Patricia D. Franklin

Open Access Articles

BACKGROUND: Data-driven surgical decisions will ensure proper use and timing of surgical care. We developed a Web-based patient-centered treatment decision and assessment tool to guide treatment decisions among patients with advanced knee osteoarthritis who are considering total knee replacement surgery.

OBJECTIVE: The aim of this study was to examine user experience and acceptance of the Web-based treatment decision support tool among older adults.

METHODS: User-centered formative and summative evaluations were conducted for the tool. A sample of 28 patients who were considering total knee replacement participated in the study. Participants' responses to the user interface design, the clarity of information ...


Identification Of Epigenetic Regulators Of Dux4-Fl For Targeted Therapy Of Facioscapulohumeral Muscular Dystrophy, Charis L. Himeda, Takako I. Jones, Ching-Man A. Virbasius, Lihua Julie Zhu, Michael R. Green, Peter L. Jones 2018 University of Massachusetts Medical School

Identification Of Epigenetic Regulators Of Dux4-Fl For Targeted Therapy Of Facioscapulohumeral Muscular Dystrophy, Charis L. Himeda, Takako I. Jones, Ching-Man A. Virbasius, Lihua Julie Zhu, Michael R. Green, Peter L. Jones

Open Access Articles

Facioscapulohumeral muscular dystrophy (FSHD) is caused by epigenetic de-repression of the disease locus, leading to pathogenic misexpression of the DUX4 gene in skeletal muscle. While the factors and pathways involved in normal repression of the FSHD locus in healthy cells have been well characterized, very little is known about those responsible for the aberrant activation of DUX4-fl in FSHD myocytes. Reasoning that DUX4-fl activators might represent useful targets for small molecule inhibition, we performed a highly targeted, candidate-based screen of epigenetic regulators in primary FSHD myocytes. We confirmed several of the strongest and most specific candidates (ASH1L, BRD2, KDM4C, and ...


Transition Of Care For Young Adults With Cleft Lip And Palate: We’Ve Got Some Growing Up To Do, Brenda Louw, Linda Vallino 2018 East Tennessee State University

Transition Of Care For Young Adults With Cleft Lip And Palate: We’Ve Got Some Growing Up To Do, Brenda Louw, Linda Vallino

ETSU Faculty Works

Participants will be able to:

  • Describe the characteristics and needs of young adults with CLP.
  • Discuss the model of transition of care for the young adult with CLP.
  • Extrapolate strategies that teams could use to improve the care of young adults with CLP.

Full abstract available through The Cleft Palate-Craniofacial Journal.


Digital Commons powered by bepress