Hearing Loss And Cognitive Decline Among Older Adults With Atrial Fibrillation: The Sage-Af Study, 2020 University of Massachusetts Medical School
Hearing Loss And Cognitive Decline Among Older Adults With Atrial Fibrillation: The Sage-Af Study, Weijia Wang, Darleen M. Lessard, Hawa Ozien Abu, David D. Mcmanus, Tanya Mailhot, Jerry H. Gurwitz, Robert Goldberg, Jane Saczynski
Population and Quantitative Health Sciences Publications
Objective: To examine the association between hearing loss and cognitive function cross-sectionally and prospectively among older adults with atrial fibrillation (AF).
Methods: Patients with AF > /= 65-year-old (n = 1244) in the SAGE (Systematic Assessment of Geriatric Elements)-AF study were recruited from five internal medicine or cardiology clinics in Massachusetts and Georgia. Hearing was assessed by a structured questionnaire at baseline. Cognitive function was assessed by Montreal Cognitive Assessment (MoCA) at baseline and one year. Cognitive impairment was defined as score < /= 23 on the MoCA. The associations between hearing loss and cognitive function were examined by multivariable adjusted logistic regression.
Results: Participants with hearing loss (n = 451, 36%) were older, more likely to be male, and have depressive symptoms than ...
Advanced Phenotyping Of Otosclerosis In An Ontario Population And Two Large Newfoundland Families, 2020 The University of Western Ontario
Advanced Phenotyping Of Otosclerosis In An Ontario Population And Two Large Newfoundland Families, Matthew B. Lucas
Electronic Thesis and Dissertation Repository
Otosclerosis is a relatively common hearing loss disorder characterized by abnormal bone growth in the otic capsule leading to stapes fixation. In approximately half of cases, otosclerosis is inherited as an autosomal dominant trait. Typically, gene discovery efforts rely on surgical confirmation, audiometry and occasionally acoustic reflexes to identify affected cases of otosclerosis within families, requiring that the otosclerosis was at an advanced stage to be detected. This makes it difficult to identify individuals with early otosclerosis. The use of advanced phenotyping to identify cases of otosclerosis was tested in an Ontario otosclerotic population as well as in two large ...
Medialized Total Ossicular Replacement Prosthesis, 2020 University of Massachusetts Medical School
Medialized Total Ossicular Replacement Prosthesis, Marc D. Polanik, Aaron K. Remenschneider
Open Access Articles
Vestibular complaints secondary to a deeply medialized ossicular prosthesis have been documented following stapedotomy1 but infrequently reported following total ossicular replacement prosthesis (TORP) placement. Lateral TORP displacement through the tympanic membrane (TM) occurs in 5% to 9% of cases2; however, medial displacement, with violation of the footplate, is rare and has only been reported following canal wall down mastoidectomy.3 For the below case, institutional review board approval was obtained from the University of Massachusetts Medical School Human Subjects Committee.
Social Media Use And Hiv Screening Uptake Among Deaf Adults In The United States: Cross-Sectional Survey Study, 2019 University of Massachusetts Medical School
Social Media Use And Hiv Screening Uptake Among Deaf Adults In The United States: Cross-Sectional Survey Study, Michael Argenyi, Poorna Kushalnagar
Open Access Articles
BACKGROUND: About 46% of US adults obtain recommended HIV screening at least once during their lifetime. There is little knowledge of screening rates among deaf and hard-of-hearing adults who primarily use American Sign Language (ASL), or of social media as a potentially efficacious route for HIV prevention outreach, despite lower HIV/AIDS-specific health literacy and potentially higher HIV seropositivity rates than hearing peers.
OBJECTIVE: We investigated both the likelihood of HIV screening uptake among deaf adults in the past year and over one year ago, and the relationship between social media use and HIV screening uptake among deaf adult ASL ...
Making The Management Of Acute Otitis Media A Snap, 2019 Children's Mercy Hospital
Making The Management Of Acute Otitis Media A Snap, Cassandra Newell, Donna Wyly, Tanis Stewart, Alaina N. Burns, Brian R. Lee, Rana El Feghaly
To improve Watchful Waiting or Safety Net Antibiotic Prescription (WW/SNAP) in children >6 months old diagnosed with acute otitis media by Advanced Practice Nurses in the Emergency Department by May 2020.
Prevention Of Oral Mucositis In Cancer Patients, 2019 Valparaiso University
Prevention Of Oral Mucositis In Cancer Patients, Patricia E. Biel
Evidence-Based Practice Project Reports
Oral mucositis [OM] is one of the most severe non-hematological problems related to cancer treatments and can impact quality of life. It is linked to poorer outcomes due to the associated weight loss, pain, dehydration, and risk of developing life-threatening infections. The purpose of this evidence-based practice project was to determine if OM is preventable with the use of an oral care protocol and zinc supplementation when compared to use of oral care protocols alone. The Johns Hopkins Nursing Evidence-Based Practice Model was used to guide project implementation in an outpatient oncology office. Recommendations were developed from an exhaustive review ...
L-Serine Reduces Reactive Oxygen Species Yield In Cisplatin Treated Zebrafish Utricles, 2018 Western Kentucky University
L-Serine Reduces Reactive Oxygen Species Yield In Cisplatin Treated Zebrafish Utricles, Satya A. Moolani, Elvin Irihamye, Jerry D. Monroe, Michael E. Smith
Cisplatin is a chemotherapy compound effective against a variety of cancers. However, it can act as an ototoxin and cause hearing loss by promoting reactive oxygen species (ROS) production in auditory tissues. The antioxidant amino acid, L-serine has been hypothesized to lower levels of cisplatin-mediated ROS. In this project, we investigated whether L-serine can reduce cisplatin-mediated ROS production in auditory tissue and potentially act as an otoprotectant during cisplatin chemotherapy. We used a zebrafish utricular tissue culture system and fluorescent ROS indicator dye to spectrophotometrically measure if L-serine could decrease reactive oxygen species levels in cisplatin-treated tissues. We found that ...
Deaf And Hard-Of-Hearing Learners In Emergency Medicine, 2018 The University Of Michigan
Deaf And Hard-Of-Hearing Learners In Emergency Medicine, Lisa M. Meeks, Alina Engelman, Alicia Booth, Michael Argenyi
Open Access Articles
Approximately 23% of Americans over age 12 have some level of hearing loss.1 Emergency departments can reduce healthcare barriers for deaf and hard-of-hearing (DHoH) patients through improved patient-physician communication. DHoH students, once they become physicians, may provide one mechanism for reducing existing healthcare disparities and communication barriers for DHoH patients, and may be more adept with patients facing other communication barriers. A renewed interest in disability access and a commitment to social justice has increased efforts toward the inclusion of individuals with disabilities in medical education and training. Despite this increased interest and a growing number of DHoH students ...
Identification Of Oral Clefts As A Risk Factor For Hearing Loss During Newborn Hearing Screening, 2018 University of Washington
Identification Of Oral Clefts As A Risk Factor For Hearing Loss During Newborn Hearing Screening, Patricia L. Purcell, Kathleen Cy Sie, Todd C. Edwards, Debra Lochner Doyle, Karin Neidt
Journal of Early Hearing Detection and Intervention
Objective: This study assessed whether children with oral clefts are appropriately classified as at-risk for hearing loss at the time of newborn hearing screening and describes their screening and diagnostic results.
Design: Birth certificates were used to identify children with cleft lip and palate or isolated cleft palate born in Washington State from 2008–2013. These were cross-referenced with the state’s Early Hearing Detection, Diagnosis and Intervention (EHDDI) database. Multivariate logistic regression was used to examine associations.
Results: Birth records identified 235 children with cleft lip and palate and 116 with isolated cleft palate. Six children were listed as ...
Bone Conduction Transmission And Head‐Shadow Effects For Unilateral Hearing Losses Fit With Transcranial Cic Hearing Aids, 2018 East Tennessee State University
Bone Conduction Transmission And Head‐Shadow Effects For Unilateral Hearing Losses Fit With Transcranial Cic Hearing Aids, Marc A. Fagelson, Colleen Noe, Jennifer Blevins, Owen Murnane
Owen D. Murnane
Bone conduction transmission and head‐shadow effects were determined with transcranial completely‐in‐the‐canal (TCCIC) CROS hearing aids. Five subjects with documented profound unilateral hearing loss and experience with traditional CROS/BICROS fittings (TCROS) were tested with a CIC hearing aid placed in their poorer ear. Peak SPL was measured at the tympanic membrane and ranged from 105–115 dB SPL at 2000 Hz. Pure‐tone crossover thresholds and functional gain tested at frequencies from 250–8000 Hz varied considerably more than the SPL measures. The pure‐tone results indicated that sensitivity in the better ear was moderately associated ...
Gap Discrimination And Speech Perception In Noise, 2018 East Tennessee State University
Gap Discrimination And Speech Perception In Noise, Marc A. Fagelson
Marc A. Fagelson
The relation between discrimination of silent gaps and speech‐in‐noise perception was measured in 20 normal‐hearing listeners using speech‐shaped noise as both the gap markers and the noise source for speech testing. In the gap discrimination experiment, subjects compared silent gaps marked by 60 dB SPL 250‐ms noise bursts to standards of either 5, 10, 20, 50, 100, or 200 ms. The gap results were most similar to those reported by Abel [S. M. Abel, J. Acoust. Soc. Am. 52, 519–524 (1972)] as ΔT/T decreased non‐monotonically with increased gap length. In a second ...
Multivariate Analysis To Identify Potential Biomarkers For Prognosis And Treatment Resistance In Head And Neck Cancer Patients, Christina Ann Wicker
Theses and Dissertations--Toxicology and Cancer Biology
It is estimated that nearly 50,000 individuals in the United States will be diagnosed with head and neck cancer in 2017 (American Cancer Society www.cancer.org). Ninety percent of oral cancers are head and neck squamous cell carcinoma (HNSCC). Major obstacles in the treatment of HNSCC are recurrence and treatment resistance, which contributes to increased mortality. Therefore, there is increased need to determine genetic alterations in HNSCC that may be ideal novel drug targets, and biomarkers to improve diagnostic and prognostic testing.
Abnormal localization and overexpression of base excision repair protein and transcriptional regulator Apurinic/Apyrimidic endonuclease (APE1 ...
Cortactin Phosphorylation By Casein Kinase 2 Regulates Actin Related Protein 2/3 Complex Activity And Invadopodia Function, 2018 West Virginia University
Cortactin Phosphorylation By Casein Kinase 2 Regulates Actin Related Protein 2/3 Complex Activity And Invadopodia Function, Steven Michael Markwell
Graduate Theses, Dissertations, and Problem Reports
Malregulation of the actin cytoskeleton enhances tumor cell motility and invasion. The actin-binding protein cortactin facilitates branched actin network formation through activation of the actin-related protein (Arp) 2/3 complex. Arp2/3 complex activation is responsible for driving increased migration and extracellular matrix (ECM) degradation by governing invadopodia formation and activity. While cortactin-mediated activation of Arp2/3 complex and invadopodia regulation has been well established, signaling pathways responsible for governing cortactin binding to Arp2/3 are unknown. In this dissertation we identify casein kinase (CK) 2α phosphorylation of cortactin as a negative regulator of Arp2/3 binding. CK2α directly phosphorylates ...
Mantle Cell Lymphoma In The Thyroid: A Rare Presentation, 2017 University of Massachusetts Medical School
Mantle Cell Lymphoma In The Thyroid: A Rare Presentation, Uzma Mohammad Siddiqui, Sarika N. Rao, Pallavi K. Galera, Nahida Islam, Mira S. Torres
Open Access Articles
Background: While 2% of all extranodal Non-Hodgkin Lymphomas present in the thyroid, there exists insufficient data to describe the incidence of mantle cell lymphoma in the thyroid. A case series of 1400 patients revealed that < 1% of thyroid lymphomas may be MCL; hence better understanding of the disease course is essential.
Patient Findings: A 65-year-old female was referred for a multinodular goiter. Multiple fine needle aspirations from the dominant right nodule were consistent with Hashimoto's thyroiditis and flow cytometry was negative. Due to progressing dysphagia, she underwent total thyroidectomy.
Summary: Pathology revealed MCL with mantle zone growth pattern in the right thyroid. Flow cytometry showed monoclonal B cells comprising 9% of total cells. The Ki-67 ...
Methicillin-Resistant Staphylococcus Aureus In Acute Otitis Externa, 2017 Harvard Medical School
Methicillin-Resistant Staphylococcus Aureus In Acute Otitis Externa, Maria J. Duarte, Elliott D. Kozin, Paulo J. M. Bispo, Andreas H. Mitchell, Michael S. Gilmore, Aaron K. Remenschneider
Open Access Articles
Objective: Otologic methicillin-resistant Staphylococcus aureus (MRSA) infection has historically been rare, but given the rise in community-acquired MRSA carriage and infection at other body sites, prevalence rates may be changing. The goal of this study was to determine the prevalence of MRSA in recent otologic cultures from patients with acute otitis externa (AOE).
Study design: Retrospective review of an institutional microbiologic database.
Methods: A retrospective analysis was performed on serial culture isolates taken from the ear at a quaternary care hospital from January 2014 to April 2016. The causative pathogen and antibiotic sensitivity was determined by culture isolation and end ...
Temporal Bone Hyperpneumatization And Tinnitus: Clinico-Radiological Evaluation Using Ct Scan, 2017 Al Sader Medical City, Najaf, Iraq
Temporal Bone Hyperpneumatization And Tinnitus: Clinico-Radiological Evaluation Using Ct Scan, Sattar Razzaq Al-Esawi, Ali Burair Hasan, Deepak Takhtani, Sarwat Hussain
Journal of Global Radiology
Purpose: We propose that there is increased incidence of subjective tinnitus (ST) in patients with temporal bone hyperpneumatization (TBHP). The secondary goal of this project is to assess the degrees of association of TBHP with paranasal sinus hyperpneumatization (PNSHP), chronic sinusitis (CS), otomastoiditis (OM) and concha bullosa (CB).
Methods and Materials: A total of 196 patients, who had computed tomography (CT) of the head for various clinical indications, were included in this study. CT head scans of patients with TBHP (n=96) were correlated with control patients (n=100). These patients had no apparent TBHP, history of ST, PNSHP, CS ...
Chemogenetic Stimulation Of The Hypoglossal Neurons Improves Upper Airway Patency, 2017 George Washington University
Chemogenetic Stimulation Of The Hypoglossal Neurons Improves Upper Airway Patency, Thomas Curado, Kenneth Fishbein, Huy Pho, Michael Brennick, Olga Dergacheva, David Mendelowitz, +Several Additional Authors
Pharmacology and Physiology Faculty Publications
Obstructive sleep apnea (OSA) is characterized by recurrent upper airway obstruction during sleep. OSA leads to high cardiovascular morbidity and mortality. The pathogenesis of OSA has been linked to a defect in neuromuscular control of the pharynx. There is no effective pharmacotherapy for OSA. The objective of this study was to determine whether upper airway patency can be improved using chemogenetic approach by deploying designer receptors exclusively activated by designer drug (DREADD) in the hypoglossal motorneurons. DREADD (rAAV5-hSyn-hM3(Gq)-mCherry) and control virus (rAAV5-hSyn-EGFP) were stereotactically administered to the hypoglossal nucleus of C57BL/6J mice. In 6–8 weeks genioglossus ...
Empty Nose Syndrome—What Do We Know?, 2017 Loma Linda University, School of Medicine
Empty Nose Syndrome—What Do We Know?, Ethan Frank, Christopher Church Md
Loma Linda University Student Journal
Empty nose syndrome is a complication of nasal surgery wherein patients develop a persistent, debilitating sense of nasal obstruction and dyspnea despite clear nasal cavities. It is characterized by a discrepancy between prominent subjective symptoms and near total lack of objective findings, making it difficult to diagnose. The pathophysiology of empty nose syndrome is a complex mix of aerodynamic, physiologic, and neurological changes leading to altered airflow and diminished sensory function. Evolving treatment options consist of medical symptom control or surgical reconstruction.
The Use Of Hyperbaric Oxygen Therapy In Idiopathic Sensorineural Hearing Loss: A Case Study, 2016 Marshall University
The Use Of Hyperbaric Oxygen Therapy In Idiopathic Sensorineural Hearing Loss: A Case Study, Chad B. Crigger, Md, Stephen L. Wilson, Md
Marshall Journal of Medicine
Idiopathic sudden sensorineural hearing loss (ISSHL) is an otologic emergency that can provoke anxiety in the patient and can be clinically challenging for the practitioner. The natural history of the condition can be as varied as its possible etiologies. Adding to the clinical challenge is the current debate of treatment modalities available. In what follows, we provide a case detailing our treatment course, including the novel use of hyperbaric oxygen therapy (HBOT) as an emerging therapy for sensorineural hearing loss. Additionally, we provide a brief review of the current state of treatment options available in the armament for ISSHL. As ...
Mumps Myocarditis: A Forgotten Disease?, 2016 Aga Khan University
Mumps Myocarditis: A Forgotten Disease?, Sheraz Hussain, Mohammad Faizan Zahid, Arshalooz J. Rahman, Mehnaz A. Atiq, S. H. Ibrahim
Department of Paediatrics and Child Health
Mumps is an acute viral illness that follows a self-limiting course but up to 10% of cases have a complicated course with the involvement of other organ systems. Myocarditis is reported as a complication but the incidence has greatly fallen ever since the development of the mumps vaccine. A child presented to our department with parotid swelling and fever. Persistent tachycardia with irregular pulse led to further cardiac work up which showed decreased ejection fraction and raised serum cardiac enzymes, indicating myocardial damage. With ionotropic agents and supportive care, there was complete normalization of ejection fraction and serum cardiac enzyme ...