Dr Hadwen Trust for Humane Research
Elon University
University of Pennsylvania
Cornell
Wilfrid Laurier University
Brandman University
The University of Texas Graduate School of Biomedical Sciences at Houston
The University of Western Ontario
A Mathematical Model Of The Inflammatory Response To Pathogen Challenge,
2018
University of Richmond
A Mathematical Model Of The Inflammatory Response To Pathogen Challenge, Lester Caudill, Fiona Lynch
Annual Symposium on Biomathematics and Ecology: Education and Research
No abstract provided.
Application Of Data Assimilation In Forecasting Of Influenza In The United States,
2018
University of Arizona
Application Of Data Assimilation In Forecasting Of Influenza In The United States, Hannah Biegel
Annual Symposium on Biomathematics and Ecology: Education and Research
No abstract provided.
Simulating Antibiotic Resistance In The Computer Lab And Biology Lab: Ideas For Undergraduate Projects,
2018
The New School
Simulating Antibiotic Resistance In The Computer Lab And Biology Lab: Ideas For Undergraduate Projects, Anne E. Yust
Annual Symposium on Biomathematics and Ecology: Education and Research
No abstract provided.
Heterogeneities In The Transmission Dynamics Of Leishmaniasis: Modeling Implications On Sustained Drive To Control It From Neglected Regions,
2018
Arizona State University at the Tempe Campus
Heterogeneities In The Transmission Dynamics Of Leishmaniasis: Modeling Implications On Sustained Drive To Control It From Neglected Regions, Anuj Mubayi
Annual Symposium on Biomathematics and Ecology: Education and Research
No abstract provided.
Mathematical Modeling And Simulation With Deep Learning Methods Of Cancer Growth For Patient-Specific Therapy,
2018
Academies of Loudoun
Mathematical Modeling And Simulation With Deep Learning Methods Of Cancer Growth For Patient-Specific Therapy, Vishal Kobla, Joshua P. Smith, Pranav Unni, Padmanabhan Seshaiyer
Annual Symposium on Biomathematics and Ecology: Education and Research
No abstract provided.
A Household Model Of German Cockroach Infestations And Their Effect On Symptoms Of Atopic Asthma,
2018
Illinois State University
A Household Model Of German Cockroach Infestations And Their Effect On Symptoms Of Atopic Asthma, Karen Funderburk
Annual Symposium on Biomathematics and Ecology: Education and Research
No abstract provided.
Developing Droplet Based 3d Cell Culture Methods To Enable Investigations Of The Chemical Tumor Microenvironment,
2018
University of New Mexico - Main Campus
Developing Droplet Based 3d Cell Culture Methods To Enable Investigations Of The Chemical Tumor Microenvironment, Jacqueline A. De Lora
Biomedical Sciences ETDs
Adaptation of cancer cells to changes in the biochemical microenvironment in an expanding tumor mass is a crucial aspect of malignant progression, tumor metabolism, and drug efficacy. In vitro, it is challenging to mimic the evolution of biochemical gradients and the cellular heterogeneity that characterizes cancer tissues found in vivo. It is well accepted that more realistic and controllable in vitro 3D model systems are required to improve the overall cancer research paradigm and thus improve on the translation of results, but multidisciplinary approaches are needed for these advances. This work develops such approaches and demonstrates that new droplet-based cell-encapsulation ...
Sources And Fates Of Carbamyl Phosphate: A Labile Energy-Rich Molecule With Multiple Facets.,
2018
George Washington University
Sources And Fates Of Carbamyl Phosphate: A Labile Energy-Rich Molecule With Multiple Facets., Dashuang Shi, Ljubica Caldovic, Mendel Tuchman
Genomics and Precision Medicine Faculty Publications
Carbamyl phosphate (CP) is well-known as an essential intermediate of pyrimidine and arginine/urea biosynthesis. Chemically, CP can be easily synthesized from dihydrogen phosphate and cyanate. Enzymatically, CP can be synthesized using three different classes of enzymes: (1) ATP-grasp fold protein based carbamyl phosphate synthetase (CPS); (2) Amino-acid kinase fold carbamate kinase (CK)-like CPS (anabolic CK or aCK); and (3) Catabolic transcarbamylase. The first class of CPS can be further divided into three different types of CPS as CPS I, CPS II, and CPS III depending on the usage of ammonium or glutamine as its nitrogen source, and whether
Modeling Hcv Interactions With P53: Implications For Carcinogenesis,
2018
Florida State University
Modeling Hcv Interactions With P53: Implications For Carcinogenesis, Harsh Jain
Biology and Medicine Through Mathematics Conference
No abstract provided.
Investigating Smoke Exposure And Chronic Obstructive Pulmonary Disease (Copd) With A Calibrated Agent Based Model (Abm) Of In Vitro Fibroblast Wound Healing.,
2018
Virginia Commonwealth University
Investigating Smoke Exposure And Chronic Obstructive Pulmonary Disease (Copd) With A Calibrated Agent Based Model (Abm) Of In Vitro Fibroblast Wound Healing., J Alex Ratti, Angela Reynolds, Rebecca L. Heise
Biology and Medicine Through Mathematics Conference
No abstract provided.
Modeling Pharmaceutical Inhibition Of Glucose-Stimulated Renin-Angiotensin System In Kidneys,
2018
Oklahoma State University - Main Campus
Modeling Pharmaceutical Inhibition Of Glucose-Stimulated Renin-Angiotensin System In Kidneys, Ashlee N. Ford Versypt, Minu R. Pilvankar, Hui Ling Yong
Biology and Medicine Through Mathematics Conference
No abstract provided.
In Vitro Aortic Arch Flow Model For Vector Flow Imaging Testing,
2018
University of Arkansas, Fayetteville
In Vitro Aortic Arch Flow Model For Vector Flow Imaging Testing, Jackson Mosley
Biomedical Engineering Undergraduate Honors Theses
Pediatric stenosis is the narrowing of the aorta at the aortic valve, above the aortic valve, or below the aortic valve. Typically, this disease’s severity is diagnosed by conventional Doppler ultrasound methods, or echocardiography. Conventional Doppler can sometimes overestimate the pressure gradient over the area of stenosis, diagnosing some cases of PAS to be more severe than they actually are. This causes earlier intervention than is desired in children. A new US modality, Vector Flow Imaging (VFI), is an angle-independent US imaging method that can potentially more accurately quantify peak blood flow velocities and pressure gradients across stenotic sections ...
Modeling Culex Tarsalis Habitat Suitability In The Great Plains Of Montana,
2018
Carroll College
Modeling Culex Tarsalis Habitat Suitability In The Great Plains Of Montana, Teal Bullick
Carroll College Student Undergraduate Research Festival
As the leading cause of arbovirus encephalitis in the United States, West Nile Virus (WNV) poses a public health risk in the state of Montana where infection rates in mosquitoes can be as high as 15%. Spatial modeling can serve as a tool for predicting outbreaks and directing prevention measures. Models for the entire state of Montana currently exist that predict WNV risk and habitat suitability of the predominant vector species Culex tarsalis. After collecting additional mosquito vector samples in the summer of 2017, I used niche modeling techniques with historic and new presence-only data to build a Cx. tarsalis ...
Skeletal, Cardiac, And Respiratory Muscle Function And Histopathology In The P448lneo- Mouse Model Of Fkrp-Deficient Muscular Dystrophy.,
2018
George Washington University
Skeletal, Cardiac, And Respiratory Muscle Function And Histopathology In The P448lneo- Mouse Model Of Fkrp-Deficient Muscular Dystrophy., Qing Yu, Melissa Morales, Ning Li, Alexander G Fritz, Ren Ruobing, Anthony Blaeser, Ershia Francois, Qi-Long Lu, Kanneboyina Nagaraju, Christopher F Spurney
Genomics and Precision Medicine Faculty Publications
BACKGROUND: Fukutin-related protein (FKRP) mutations are the most common cause of dystroglycanopathies known to cause both limb girdle and congenital muscular dystrophy. The P448Lneo- mouse model has a knock-in mutation in the FKRP gene and develops skeletal, respiratory, and cardiac muscle disease.
METHODS: We studied the natural history of the P448Lneo- mouse model over 9 months and the effects of twice weekly treadmill running. Forelimb and hindlimb grip strength (Columbus Instruments) and overall activity (Omnitech Electronics) assessed skeletal muscle function. Echocardiography was performed using VisualSonics Vevo 770 (FujiFilm VisualSonics). Plethysmography was performed using whole body system (ADInstruments). Histological evaluations included ...
Melatonin Attenuates Oxidative Stress And Modulates Inflammatory Response After Experimental Burn Trauma,
2018
Medical University of Varna, Department of Physiology and Pathophysiology
Melatonin Attenuates Oxidative Stress And Modulates Inflammatory Response After Experimental Burn Trauma, Minka Hristova, Ganka Bekyarova, Milena Atanasova, Maria Tzaneva
Journal of Mind and Medical Sciences
Introduction. Thermal injury activates an inflammatory response. Melatonin possesses anti-oxidant and anti-inflammatory properties. The objective of the present work was to study melatonin effects on the inflammatory response under conditions of oxidative stress during the early stage of thermal injury.
Materials and methods. We used 24 white male rats of Wistar breed, randomly divided into three experimental groups. Group one was the control, group two was inflicted with burn trauma, and group three was inflicted with burn trauma, with melatonin application following the thermal injury. Melatonin was applied twice in doses of 10 g/kg b.m. immediately after the ...
Studies Of Amino Acid Mutations In Drug Resistance Of The Smo Protein,
2018
University of Nebraska at Omaha
Studies Of Amino Acid Mutations In Drug Resistance Of The Smo Protein, Eunice Wintona
Student Research and Creative Activity Fair
Smoothened receptor (SMO) is a protein that in humans, is encoded by the SMO gene. A systemic mutation in its binding pocket helps predict the sensitivity of mutant proteins to different drugs. Known as a GPCR-like receptor, it is a component of the hedgehog signaling pathway; a pathway involved in body patterning and the regulation of adult stem cells. An uncontrolled or inappropriate activation of the Hedgehog pathway drives tumor progression in cancers and a number of birth defects. To achieve these goals, the molecular modeling software MOE was used to build small molecules and drug molecules like Vismodegib and ...
Characterization Of The Roles Of Muscle-Synthesized Brain-Derived Neurotrophic Factor And Presynaptic Tyrosine Receptor Kinase B In Motor Neuron Axonal Transport,
2018
Northern Michigan University
Characterization Of The Roles Of Muscle-Synthesized Brain-Derived Neurotrophic Factor And Presynaptic Tyrosine Receptor Kinase B In Motor Neuron Axonal Transport, Luke A. Vanosdol
All NMU Master's Theses
Brain-derived neurotrophic factor (BDNF) is a small, diffusible protein essential for the development and function of neurons. It is synthesized by many types of tissue, including muscle. BDNF actions are mediated via binding to its receptor, tyrosine receptor kinase B (TrkB). The BDNF-TrkB complex is endocytosed into a specialized vesicle, which induces downstream signaling cascades locally in the dendrites, or, more often, is delivered to the cell soma via retrograde axonal transport, where it modulates gene expression. BDNF activation of TrkB is critical for the initiation of axonal transport, and this cellular process relies on the interaction of numerous adaptor ...
Rest Upregulates Gremlin To Modulate Diffuse Intrinsic Pontine Glioma Vasculature,
2018
George Washington University
Rest Upregulates Gremlin To Modulate Diffuse Intrinsic Pontine Glioma Vasculature, Shavali Shaik, Bridget Kennis, Shinji Maegawa, Keri Schadler, Yang Yanwen, Javad Nazarian, +Several Additional Authors
Genomics and Precision Medicine Faculty Publications
Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive glial tumor that occurs in children. The extremely poor median and 5-year survival in children afflicted with DIPG highlights the need for novel biology-driven therapeutics. Here, we have implicated the chromatin remodeler and regulator of brain development called RE1 Silencing Transcription Factor (REST), in DIPG pathology. We show that REST protein is aberrantly elevated in at least 21% of DIPG tumors compared to normal controls. Its knockdown in DIPG cell lines diminished cell growth and decreased their tumorigenicity in mouse intracranial models. DIPGs are vascularized tumors and interestingly, REST loss in ...
Molecular And Functional Analysis Of Anchorage Independent, Treatment-Evasive Neuroblastoma Tumorspheres With Enhanced Malignant Properties: A Possible Explanation For Radio-Therapy Resistance,
2018
George Washington University
Molecular And Functional Analysis Of Anchorage Independent, Treatment-Evasive Neuroblastoma Tumorspheres With Enhanced Malignant Properties: A Possible Explanation For Radio-Therapy Resistance, Tamara Abou-Antoun, Javad Nazarian, Anthony Ghanem, Stanislav Vukmanovic, Anthony D. Sandler
Genomics and Precision Medicine Faculty Publications
Despite significant advances in cancer treatment and management, more than 60% of patients with neuroblastoma present with very poor prognosis in the form of metastatic and aggressive disease. Solid tumors including neuroblastoma are thought to be heterogeneous with a sub-population of stem-like cells that are treatment-evasive with highly malignant characteristics. We previously identified a phenomenon of reversible adaptive plasticity (RAP) between anchorage dependent (AD) cells and anchorage independent (AI) tumorspheres in neuroblastoma cell cultures. To expand our molecular characterization of the AI tumorspheres, we sought to define the comprehensive proteomic profile of murine AD and AI neuroblastoma cells. The proteomic ...
Investigating Smoke Exposure And Chronic Obstructive Pulmonary Disease (Copd) With A Calibrated Agent Based Model (Abm) Of In Vitro Fibroblast Wound Healing.,
2018
Virginia Commonwealth University
Investigating Smoke Exposure And Chronic Obstructive Pulmonary Disease (Copd) With A Calibrated Agent Based Model (Abm) Of In Vitro Fibroblast Wound Healing., James A. Ratti
Theses and Dissertations
COPD is characterized by tissue inflammation and impaired remodeling that suggests fibroblast maintenance of structural homeostasis is dysregulated. Thus, we performed in vitro wound healing experiments on normal and diseased human lung fibroblasts and developed an ABM of fibroblasts closing a scratched monolayer using NetLogo to evaluate differences due to COPD or cigarette smoke condensate exposure. This ABM consists of a rule-set governing the healing response, accounting for cell migration, proliferation, death, activation and senescence rates; along with the effects of heterogeneous activation, phenotypic changes, serum deprivation and exposure to cigarette smoke condensate or bFGF. Simulations were performed to calibrate ...
