Dr Hadwen Trust for Humane Research
Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health
University of Tennessee, Knoxville
Augustana College, Rock Island Illinois
University of Nebraska - Lincoln
University of South Carolina - Columbia
Harvey Mudd College/Pomona College
University of Mississippi
Virginia Commonwealth University
University of Maine
Vitamin C Contributes To Epigenetic Regulation Of Genes Related To Diabetic Retinopathy In Retinal Endothelial Cells,
2023
Noorda College of Osteopathic Medicine
Vitamin C Contributes To Epigenetic Regulation Of Genes Related To Diabetic Retinopathy In Retinal Endothelial Cells, Elizabeth L. Turner, Jonathon Reynolds, Walker Kay, Marianne Becnel, Matthew Conway, Alexander Kim, John A. Kriak, Kyle B. Bills, David W. Sant
Annual Research Symposium
No abstract provided.
Establishment Of An In Vivo Streptozotocin-Induced Type 1 Diabetes Model Recapitulating Early Brain And Retinal Fibrosis,
2022
Carolinas Medical Center
Establishment Of An In Vivo Streptozotocin-Induced Type 1 Diabetes Model Recapitulating Early Brain And Retinal Fibrosis, Kia Bourdot, Lucy Dawson, Igor Kuzin, Arturo Bravo Nuevo, Zeus Antonello
Cooper Rowan Medical Journal
INTRODUCTION: Diabetes has risen to one of the top American public health concerns. The hyperglycemic state of chronic diabetes leads to microvascular and macrovascular changes that predispose patients to delayed wound healing and organ fibrosis. The validation of models to specifically detect early, quantifiable fibrotic changes seen in the diabetic state is of fundamental importance for understanding the diabetic pathophysiology and exploring earlier management options. Here, we investigated if we could detect early signs of internal fibrosis in a streptozotocin (STZ) diabetic mouse model by quantifying α-SMA expression in various organs using flow cytometry.
METHODS: We used a low-dose STZ-induced …
Physics-Informed Neural Networks For Informed Vaccine Distribution In Heterogeneously Mixed Populations,
2022
George Mason University
Physics-Informed Neural Networks For Informed Vaccine Distribution In Heterogeneously Mixed Populations, Alvan Arulandu, Padmanabhan Seshaiyer
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Humanizing Mathematical Biology Research And Education,
2022
Bates College
Humanizing Mathematical Biology Research And Education, Carrie Diaz Eaton, Ognyan Simeonov
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
The Effect Of Vaccine Misinformation On Disease Spread,
2022
Benedictine University
The Effect Of Vaccine Misinformation On Disease Spread, Anthony Delegge, Yina Wang
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Stochastic Models Of Zoonotic Avian Influenza With Multiple Hosts, Environmental Transmission, And Migration In The Natural Reservoir,
2022
Illinois State University
Stochastic Models Of Zoonotic Avian Influenza With Multiple Hosts, Environmental Transmission, And Migration In The Natural Reservoir, Kaia Smith
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Modeling The Effects Of Media Awareness On Sars-Cov-2 Transmission In Georgia,
2022
Augusta University
Modeling The Effects Of Media Awareness On Sars-Cov-2 Transmission In Georgia, Eric Numfor
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Ischaemic Hepatitis (Ih): Modeling Outcome Based On Ih Patients' Attributes,
2022
Illinois State University
Ischaemic Hepatitis (Ih): Modeling Outcome Based On Ih Patients' Attributes, Madison Utterback, Christiana Beard
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
An Agent-Based Model Of Environmental Transmission Of Clostridioides Difficile In Healthcare Settings,
2022
Lewis University
An Agent-Based Model Of Environmental Transmission Of Clostridioides Difficile In Healthcare Settings, Max Lewis, Laila Mahrat, Cara Sulyok, Brittany Stephenson
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
An Agent-Based Model Of Covid-19 Transmission At Lewis University,
2022
Lewis University
An Agent-Based Model Of Covid-19 Transmission At Lewis University, Austin Kind, Brittany Stephenson Phd
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Mixture Models For Interval Censored Outcomes,
2022
University of Massachusetts Amherst
Mixture Models For Interval Censored Outcomes, Yibai Zhao
Doctoral Dissertations
Silent events such as the first detectable HIV infection, the onset of Type 2 diabetes and prostate cancer progression are often ascertained by diagnostic tests and/or self-reports that are scheduled periodically. In such applications, we only observe the time to the event of interest to lie between the times of last negative and the first positive tests, resulting in interval-censored observations. In addition, in some medical studies, a substantial proportion of participants may experience the events before the study, so-called prevalent cases, or participants may never experience the event, that is regarded as non-susceptible cases (or indolent cancer or long-term …
Cost Analysis Of Implementing An Exercise Program For Fall And Fracture Prevention In Older Adults On Proton Pump Inhibitor Therapy,
2022
Advocate Lutheran General Hospital
Cost Analysis Of Implementing An Exercise Program For Fall And Fracture Prevention In Older Adults On Proton Pump Inhibitor Therapy, Thomas Adam Wichelmann, Nhan Dang, David H. Kruchko, Sufyan Abdulmujeeb, Eli D. Ehrenpreis
Journal of Patient-Centered Research and Reviews
Purpose: Falls have significant financial impact. Proton pump inhibitor (PPI) therapy is associated with an increased risk of falls and fractures. Exercise programs have been shown to decrease risk of falls in the elderly population and are recommended by the U.S. Preventive Services Task Force for patients over age 65 to reduce falls. Our study aimed to explore the potential financial benefit of implementing three different Centers for Disease Control and Prevention-recommended exercise-based interventions for fall prevention (Tai Chi, Stepping On, and Otago Exercise Program) in ≥ 65-year-old patients on PPI therapy.
Methods: A Markov model was developed to predict …
Comparing Antigenaemia - And Microfilaraemia As Criteria For Stopping Decisions In Lymphatic Filariasis Elimination Programmes In Africa,
2022
Erasmus University of Rotterdam
Comparing Antigenaemia - And Microfilaraemia As Criteria For Stopping Decisions In Lymphatic Filariasis Elimination Programmes In Africa, Wilma A. Stolk, Luc E. Coffeng, Fatorma K. Bolay, Obiora A. Eneanya, Peter U. Fischer, T Deirdre Hollingsworth, Benjamin G. Koudou, Aboulaye Meite, Edwin Michael, Joaquin M. Prada, Rocio M. Caja Rivera, Swarnali Sharma, Panayiota Touloupou, Gary J. Weil, Sake J. De Vlas
Data and Supporting Files
Data collected from participants at four separate timepoints in Cote d'Ivoire and Liberia identified by a unique participant ID. There are four timepoints collected from each country: Baseline, Follow-up Year 1, Follow-Up Year 2, and Follow-up Year 3. Each dataset includes the participant ID, gender, age, the microfilarae (MF) count collected through blood smear, and circulating filarial antigen (CFA) result from a strip test.
Rna Isolation In Duchenne Muscular Dystrophy (Dmd) Mice Models,
2022
Western University
Rna Isolation In Duchenne Muscular Dystrophy (Dmd) Mice Models, Salem Abu Al-Burak
Undergraduate Student Research Internships Conference
Fibrosis is a progressive and typically irreversible disease process characterized by the excessive deposition of collagen in organs and in tissues of the musculoskeletal (MSK) system1,2. This process, which causes loss of organ and tissue function, can be initiated by micro-traumas3, an excessive and/or prolonged immune response1, the activation and proliferation of fibrosis-inducing progenitor cells4, and a pro-fibrotic extra-cellular microenvironment5. In parallel with the events that initiate fibrosis, genetic or environmental influences may cause cells and tissues to become predisposed to fibrosis development prior to initiation. This suggests that these …
Effects Of Dietary Ω-3 Polyunsaturated Fatty Acids (N-3 Pufa) In Light Sensitivity Of Retinas Of Mice Models To Prevent Retinal Damage,
2022
University of Tennessee Health Science Center
Effects Of Dietary Ω-3 Polyunsaturated Fatty Acids (N-3 Pufa) In Light Sensitivity Of Retinas Of Mice Models To Prevent Retinal Damage, Aaron Eugene Rice
Longitudinal Scholar's Project
Light-induced retinal degeneration (LIRD) causes photoreceptor cell death in albino mice after exposure to high intensity light for a set period of time (6-24 hours). This causes retinal photoreceptor cell death through apoptosis. From several previous studies, Dr. Mandal’s lab concluded that de novo biosynthesis of ceramide mediates photoreceptor cell death in a LIRD model. Previous studies in Dr. Mandal’s lab has shown that mouse models with higher endogenous ω-3 Polyunsaturated Fatty Acids (n-3 PUFA) generates less ceramide upon neuronal injury and prevent neurodegeneration (Mol Neurobio 2021). There are currently not many available effective therapies for retinal degeneration in humans …
The Role Of The Hypoxia-Inducible Factor 2 In Pancreatic Cancer: Mechanisms Of Tumor Immunosuppression And Intestinal Radioprotection,
2022
The Texas Medical Center Library
The Role Of The Hypoxia-Inducible Factor 2 In Pancreatic Cancer: Mechanisms Of Tumor Immunosuppression And Intestinal Radioprotection, Carolina Garcia Garcia
The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences Dissertations and Theses (Open Access)
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with dismal prognosis. The only curative option for patients is surgery, but over 80% of patients are not surgical candidates. Unfortunately, PDAC is resistant to the three remaining options. PDAC is characterized by a profoundly hypoxic and immunosuppressive stroma, which contributes to its therapeutic recalcitrance. Alpha-smooth muscle actin+ (αSMA+) cancer-associated fibroblasts (CAFs) are the most abundant stromal component, as well as mediators of stromal deposition. The hypoxia-inducible factors (HIF1 and HIF2) coordinate responses to hypoxia, yet, despite their known association to poor patient outcomes, their functions within the PDAC tumor microenvironment (TME) …
A Theoretical Perspective On Parasite-Host Coevolution With Alternative Modes Of Infection,
2022
The University of Western Ontario
A Theoretical Perspective On Parasite-Host Coevolution With Alternative Modes Of Infection, George N. Shillcock
Electronic Thesis and Dissertation Repository
We investigate how natural selection shapes the coevolution of parasitism. We discuss the antagonism fuelled by parasites’ necessity to transmit to novel hosts, and host’s desire to minimise virulence. In support, we build a mathematical model which considers the epidemiology and life-history trade-offs faced by an obligate microparasite and its host. Our model allows parasites to be transmitted to new hosts via direct contact (horizontally) or from parent to offspring during birth (vertically). We test the hypothesis that vertical transmission causes virulence to diminish in the long run, and contrary to widely accepted views, find that vertical transmission need not …
The Effect Of Fibrodysplasia Ossificans Progressiva On The Tongue,
2022
University of Connecticut - Storrs
The Effect Of Fibrodysplasia Ossificans Progressiva On The Tongue, Amy Backal, Amanda Harrop, David J. Goldhamer Dr.
University Scholar Projects
FOP is a rare genetic disorder in which skeletal muscle and associated connective tissue progressively turn to bone through a process called heterotopic ossification (HO). The extra skeletal bone growth is cumulative, eventually trapping patients in a second skeleton that eventually leads to death by asphyxiation. The FOP mutation is autosomal dominant that can be inherited or acquired sporadically. Unfortunately, FOP is currently incurable with no therapeutic options to inhibit bone growth or reduce existing bone nodules. My project intends to further our understanding of the cellular mechanisms of the disease within the tongue muscle. A population of cells known …
The Effect Of Fibrodysplasia Ossificans Progressiva On The Tongue,
2022
University of Connecticut - Storrs
The Effect Of Fibrodysplasia Ossificans Progressiva On The Tongue, Amy Backal, Amanda Harrop, David J. Goldhamer Dr.
Honors Scholar Theses
FOP is a rare genetic disorder in which skeletal muscle and associated connective tissue progressively turn to bone through a process called heterotopic ossification (HO). The extra skeletal bone growth is cumulative, eventually trapping patients in a second skeleton that eventually leads to death by asphyxiation. The FOP mutation is autosomal dominant that can be inherited or acquired sporadically. Unfortunately, FOP is currently incurable with no therapeutic options to inhibit bone growth or reduce existing bone nodules. My project intends to further our understanding of the cellular mechanisms of the disease within the tongue muscle. A population of cells known …
Leveraging Single Cell Technologies For The Characterization And Treatment Of Refractory Pancreatic Cancer,
2022
The Texas Medical Center Library
Leveraging Single Cell Technologies For The Characterization And Treatment Of Refractory Pancreatic Cancer, Maria Monberg
The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences Dissertations and Theses (Open Access)
Heterogeneity is a hallmark of cancer, and the advent of multimodal single-cell technologies has helped uncover heterogeneity in a high-throughput manner in different cancers across varied contexts at an unprecedented resolution. In an effort to improve precision medicine approaches in pancreatic ductal adenocarcinoma (PDAC), a highly lethal malignancy with a mere 11% 5-year survival rate, this dissertation focuses on first questioning the assumptions of the most basic models used to study PDAC via multimodal single-cell characterization methods at multiple levels of biological organization (scCNVseq and snATACseq for DNA assays, scRNAseq for transcriptomics, and paired protein assays such as multiplexed immunofluorescence …
