Disease Modeling Commons™
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Recent Articles in Disease Modeling
Diet-Induced Obesity: Dopaminergic And Behavioral Mechanisms As Outcomes And Predictors, Vidya Narayanaswami 
University of Kentucky
Diet-Induced Obesity: Dopaminergic And Behavioral Mechanisms As Outcomes And Predictors, Vidya Narayanaswami
Theses and Dissertations--Pharmacy
Obesity and drug abuse share common neural circuitries including the mesocoticolimbic and striatal dopamine reward system. In the current study, a rat model of diet-induced obesity (DIO) was used to determine striatal dopamine function, impulsivity and motivation as neurobehavioral outcomes and predictors of obesity. For the outcome study, rats were randomly assigned a high-fat (HF) or a low-fat (LF) diet for 8 wk. Following the 8-wk HF-diet exposure, rats were segregated into obesity-prone and obesity-resistant groups based on maximum and minimum body weight gain, respectively, and neurobehavioral outcomes were evaluated. For the predictor study, neurobehavioral antecedents were evaluated prior to ...
Gastrointestinal-Sparing Effects Of Novel Nsaids In Rats With Compromised Mucosal Defence, Rory W. Blackler 
McMaster University
Gastrointestinal-Sparing Effects Of Novel Nsaids In Rats With Compromised Mucosal Defence, Rory W. Blackler
Open Access Dissertations and Theses
Nonsteroidal anti-inflammatory drugs are among the most commonly used prescription and over-the-counter medications, but they often produce significant gastrointestinal ulceration and bleeding, particularly in elderly patients and patients with certain co-morbidities. Novel anti-inflammatory drugs are seldom tested in animal models that mimic the high-risk human users, leading to an underestimate of the true toxicity of these drugs. In the present study we examined the effects of two novel NSAIDs and two commonly used NSAIDs in models in which mucosal defence was expected to be impaired. Naproxen, celecoxib, ATB-346 (a hydrogen sulfide- and naproxen-releasing compound) and NCX 429 (a nitric oxide- ...
Popular Institutions
Popular Authors
Cristina Lanzas
University of Tennessee, Knoxville
Tianxi Cai
COBRA
Vidya Narayanaswami
University of Kentucky
L. J. Wei
COBRA
Rory Blackler
McMaster University
Solsire Zevallos
University of Pennsylvania
Gillian Ritson
University of Pennsylvania
Lu Tian
COBRA
Jeremy Taylor
COBRA
Marc Colangelo
McMaster University
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Popular Articles
Adaptive Responses To Flooding Incidents In Ilorin, Kwara State, Nigeria
Diet-Induced Obesity: Dopaminergic And Behavioral Mechanisms As Outcomes And Predictors, Vidya Narayanaswami
Environmental Problems Of Industrialization And Sustainable Development In Nigeria - A Review
Gastrointestinal-Sparing Effects Of Novel Nsaids In Rats With Compromised Mucosal Defence, Rory Blackler
The Role Of Sonic Hedgehog In The Hypothalamus, Solsire Zevallos
Photoacoustic Detection Of Red Blood Cell Aggregation
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