Skin and Connective Tissue Diseases Commons™
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Recent Articles in Skin and Connective Tissue Diseases
Characterization Of Differentiation And Prognostic Biomarkers On Cd8+ Tumor-Infiltrating Lymphocytes In Metastatic Melanoma, Richard C. Wu 
Texas Medical Center Library
Characterization Of Differentiation And Prognostic Biomarkers On Cd8+ Tumor-Infiltrating Lymphocytes In Metastatic Melanoma, Richard C. Wu
UT GSBS Dissertations and Theses (Open Access)
CD8+ cytotoxic T lymphocytes (CTL) frequently infiltrate tumors, yet most melanoma patients fail to undergo tumor regression. We studied the differentiation of the CD8+ tumor-infiltrating lymphocytes (TIL) from 44 metastatic melanoma patients using known T-cell differentiation markers. We also compared CD8+ TIL against the T cells from matched melanoma patients’ peripheral blood. We discovered a novel subset of CD8+ TIL co-expressing early-differentiation markers, CD27, CD28, and a late/senescent CTL differentiation marker, CD57. This CD8+CD57+ TIL expressed a cytolytic enzyme, granzyme B (GB), yet did not express another cytolytic pore-forming molecule, perforin (Perf). In contrast, the CD8+CD57+ T ...
Raman Spectroscopic Analysis Of Human Skin Tissue Sections Ex-Vivo: Evaluation Of The Effects Of Tissue Processing And Dewaxing, Syed Mehmood Ali, Franck Bonnier, Ali Tfayli, Helen Lambkin, Kathleen Flynn, Vincent McDonagh, Claragh Healy, Thomas Lee, Fiona Lyng, Hugh Byrne 
Dublin Institute of Technology
Raman Spectroscopic Analysis Of Human Skin Tissue Sections Ex-Vivo: Evaluation Of The Effects Of Tissue Processing And Dewaxing, Syed Mehmood Ali, Franck Bonnier, Ali Tfayli, Helen Lambkin, Kathleen Flynn, Vincent Mcdonagh, Claragh Healy, Thomas Lee, Fiona Lyng, Hugh Byrne
Articles
Raman spectroscopy coupled with K-means clustering analysis (KMCA) is employed to elucidate the biochemical structure of human skin tissue sections, and the effects of tissue processing. Both hand and thigh sections of human cadavers were analysed in their unprocessed and formalin fixed paraffin processed (FFPP) and subsequently dewaxed forms. In unprocessed sections, KMCA reveals clear differentiation of the stratum corneum, intermediate underlying epithelium and dermal layers for sections from both anatomical sites. The stratum corneum is seen to be relatively rich in lipidic content; the spectrum of the subjacent layers is strongly influenced by the presence of melanin, while that ...
Popular Institutions
Popular Authors
Joshua Reynolds
Liberty University
Hugh Byrne
Dublin Institute of Technology
Timothy Beer
Thomas Jefferson University
Laura Thompson
Philadelphia College of Osteopathic Medicine
Josh Gregorio
Texas Medical Center Library
Andrea Cardine
Philadelphia College of Osteopathic Medicine
Jonathan Blackledge
Dublin Institute of Technology
Jared Churko
Western University
Fung Chan
Marshall University
Melanie Schwer
Philadelphia College of Osteopathic Medicine
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Popular Articles
Analysis Of The Effects And Current Treatments Of Laminin Deficiency, Joshua Reynolds
Solar Radiation Damage To Human Skin Mitochondria
Malignant Peripheral Nerve Sheath Tumor (Mpnst): An Overview With Emphasis On Pathology, Imaging And Management Strategies., Timothy Beer
Dermoscopy: An Evidence-Based Approach For The Early Detection Of Melanoma
Is Ceftobiprole A Safe And Effective Treatment For Skin And Skin Structure Infections?, Laura Thompson
Is The Use Of Narrowband Ultraviolet B (Nb-Uvb) Phototherapy Effective Monotherapy In The Treatment Of Adults With Plaque Psoriasis?, Andrea Cardine
Plasmacytoid Dendritic Cells Sense Skin Injury And Promote Wound Healing Through Type I Interferons, Josh Gregorio
Moletest: A Web-Based Skin Cancer Screening System, Jonathan Blackledge
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