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Cytokine Storm In Covid-19: An Overview, Mechanism, Treatment Strategies, And Stem Cell Therapy Perspective, Nuriza Ulul Azmi, Meidi Utami Puteri, Donny Lukmanto 2020 Laboratory of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia

Cytokine Storm In Covid-19: An Overview, Mechanism, Treatment Strategies, And Stem Cell Therapy Perspective, Nuriza Ulul Azmi, Meidi Utami Puteri, Donny Lukmanto

Pharmaceutical Sciences & Research

Coronavirus disease 2019 (COVID-19) is the disease caused by the highly transmittable novel coronavirus (SARS-CoV-2) infections. The disease was found at the end of December 2019, in Wuhan, China, and quickly spread worldwide with a higher mortality rate compared to the previous coronavirus disease. Cytokine plays an important role in the inflammatory response against coronavirus infection. However, in severely ill patients with COVID-19, an excessive amount of cytokine serum level (cytokine storm) has been associated with the aggravation of coronavirus disease leading to acute respiratory distress syndrome (ARDS). Thus, the management of the cytokine storm could be the key to ...


Insights From Individuals With Chronic Conditions In The Context Of Covid-19, B. Stephen Burton, Jonathan Patterson, Mackenzie Robinson, Dhiren Patel, Matt Allison, Kelly J. Brassil 2020 Pack Health

Insights From Individuals With Chronic Conditions In The Context Of Covid-19, B. Stephen Burton, Jonathan Patterson, Mackenzie Robinson, Dhiren Patel, Matt Allison, Kelly J. Brassil

Patient Experience Journal

The objective of this prospective survey series was to evaluate knowledge and concerns related to the COVID-19 pandemic among individuals with one or more chronic conditions, including cardiometabolic, autoimmune, respiratory and cancer diagnoses. Two surveys were distributed consisting of up to 55 items (March; n=1069) and up to 71 items (April, n=1126), with 24 items repeated from the first survey. Questions focused on healthcare access, barriers and concerns related to the COVID-19 virus. Descriptive analysis evaluated central tendencies, spread, and frequencies of the demographic data, disease states, and survey results within and between the two survey timepoints. Results ...


Prospects For Rnai Therapy Of Covid-19, Hasan Uludağ, Kylie Parent, Hamidreza Montazeri Aliabadi, Azita Haddadi 2020 University of Alberta

Prospects For Rnai Therapy Of Covid-19, Hasan Uludağ, Kylie Parent, Hamidreza Montazeri Aliabadi, Azita Haddadi

Pharmacy Faculty Articles and Research

COVID-19 caused by the SARS-CoV-2 virus is a fast emerging disease with deadly consequences. The pulmonary system and lungs in particular are most prone to damage caused by the SARS-CoV-2 infection, which leaves a destructive footprint in the lung tissue, making it incapable of conducting its respiratory functions and resulting in severe acute respiratory disease and loss of life. There were no drug treatments or vaccines approved for SARS-CoV-2 at the onset of pandemic, necessitating an urgent need to develop effective therapeutics. To this end, the innate RNA interference (RNAi) mechanism can be employed to develop front line therapies against ...


Outlaw Operators: Prevention Failures And The Resurgence Of Black Lung In Central Appalachia, Aysha Bodenhamer 2020 Radford University

Outlaw Operators: Prevention Failures And The Resurgence Of Black Lung In Central Appalachia, Aysha Bodenhamer

The Carsey School of Public Policy at the Scholars' Repository

In this brief, author Aysha Bodenhamer describes how prevention failures in the coal mining industry have resulted in the resurgence of black lung disease. Caused by the chronic inhalation of coal and silica dust, black lung is progressive, incurable, life-altering, and fatal. Despite it being a preventable disease, black lung is resurgent among coal miners in Kentucky, Virginia, and West Virginia. Fieldwork including in-depth interviews with miners, clinic workers, black lung attorneys, government employees, and lay advocates, and a case-study analysis of two black lung clinics in southwest Virginia inform this analysis. These data reveal that coal operators routinely evade ...


Covid-19 Detection From Chest X-Ray Images Using Cnns Models: Further Evidence From Deep Transfer Learning, Mohamed Samir Boudrioua 2020 Ronin institute

Covid-19 Detection From Chest X-Ray Images Using Cnns Models: Further Evidence From Deep Transfer Learning, Mohamed Samir Boudrioua

The University of Louisville Journal of Respiratory Infections

Introduction: The early automatic diagnosis of the novel coronavirus (COVID-19) disease could be very helpful to reduce its spread around the world. In this study, we revisit the identification of COVID-19 from chest X-ray images using Deep Learning.

Methods: We collect a relatively large COVID-19 dataset comparing with previous studies that contain 309 real COVID-19 chest x-ray images. We also prepare 2,000 chest x-ray images of pneumonia cases and 1,000 images of healthy chest cases. Deep Transfer Learning is used to detect abnormalities in our image dataset. We fine-tune three, pre-trained convolutional neural networks (CNNs) models on a ...


Convalescent Plasma In Covid-19, Ranjit S. Banwait, Joshua K. Salabei, Troy J. Fishman, Uma G. Iyer 2020 UCF/HCA

Convalescent Plasma In Covid-19, Ranjit S. Banwait, Joshua K. Salabei, Troy J. Fishman, Uma G. Iyer

HCA Healthcare Journal of Medicine

The recent pandemic of SARS-CoV-2, which causes novel coronavirus disease 2019 (Covid-19), has had devastating impact on a global and national scale. In order to overcome this outbreak it is imperative we find treatments that are safe and effective. To date, no definitive treatment is available that can curtail the spread of this viral syndrome. Convalescent plasma (CP) is one such option that has repeatedly served as an important tool in treatment of various bacterial and viral infections, especially in the setting of no specific antimicrobial or vaccination against an infectious disease. Herein, we review the history of CP, prior ...


Improving Latent Tuberculosis Infection (Ltbi) Screening And Treatment In A School-Based Setting, Andrea Bell 2020 University of San Diego

Improving Latent Tuberculosis Infection (Ltbi) Screening And Treatment In A School-Based Setting, Andrea Bell

Doctor of Nursing Practice Final Manuscripts

Abstract

Background: San Diego County’s tuberculosis (TB) incidence rate is nearly double than the national rate. In 2019, there have been 5 cases of active TB in the county’s public high schools, which have demonstrated the need for prevention interventions in this setting.

Objectives: This evidence-based project is aimed to increase awareness, screening and treatment of latent TB infection (LTBI) in the school setting.

Methods: A TB risk assessment form and consent was sent in the registration packets. A one-time TB educational presentation was given to high school freshman students with a pretest and posttest. For students at-risk ...


The Incidence Of Node-Positive Non-Small-Cell Lung Cancer Undergoing Sublobar Resection And The Role Of Radiation In Its Management, John M. Varlotto, Isabel Cristina Martins Emmerick, Debra Maddox, Christine Herbert, Molly Griffin, Paul Rava, Thomas J. Fitzgerald, Paulo Oliveira, Jennifer Baima, Rahul N. Sood, William Walsh, Lacey J. McIntosh, Feiran Lou, Mark W. Maxfield 2020 University of Massachusetts Medical School

The Incidence Of Node-Positive Non-Small-Cell Lung Cancer Undergoing Sublobar Resection And The Role Of Radiation In Its Management, John M. Varlotto, Isabel Cristina Martins Emmerick, Debra Maddox, Christine Herbert, Molly Griffin, Paul Rava, Thomas J. Fitzgerald, Paulo Oliveira, Jennifer Baima, Rahul N. Sood, William Walsh, Lacey J. Mcintosh, Feiran Lou, Mark W. Maxfield

University of Massachusetts Medical School Faculty Publications

Purpose: To identify the incidence, preoperative risk factors, and prognosis associated with pathologically positive lymph node (pN+) in patients undergoing a sub-lobar resection (SLR).

Methods: This is a retrospective study using the National Cancer Database (NCDB) from 2004 to 2014 analyzing SLR excluding those with any preoperative chemotherapy and/or radiation, follow-up < 3 months, stage IV disease, or > 1 tumor nodule. Multivariable modeling (MVA) was used to determine factors associated with overall survival (OS). Propensity score matching (PSM) was used to determine preoperative risk factors for pN+ in patients having at least one node examined to assess radiation's effect on OS in those patients with ...


The Covid-19 Pandemic And The Power Of Numbers, Jessica Ancker 2020 Weill Cornell Medical College

The Covid-19 Pandemic And The Power Of Numbers, Jessica Ancker

Numeracy

The COVID-19 pandemic has produced a deluge of news coverage of quantitative concepts. In this viewpoint, we provide examples of effective and poor quantitative communication by the professional news media as well as social media communicators. Effective examples include a number of online animations and engaging interactive simulations. Examples of poor quantitative communication include the widespread reporting of raw numbers rather than rates, failing to address uncertainty, not providing sufficient context for numbers, and not discussing the implications of false negative and false positive diagnostic test results. Educators can draw from this body of news to develop compelling quantitative literacy ...


Maternal Education And Cockroach Sensitization In Asthmatic Children, Jessica S. Van Mason, Ryan Allenbrand, David Williams, Kevin Kennedy, Salman Aljubran 2020 Children's Mercy Hospital - Program Manager of Healthy Homes

Maternal Education And Cockroach Sensitization In Asthmatic Children, Jessica S. Van Mason, Ryan Allenbrand, David Williams, Kevin Kennedy, Salman Aljubran

Research Days

No abstract provided.


Angiopoietin 1 Protects Against Lps-Induced Acute Lung Injury And Alveolar Remodeling In Neonatal Mice, Umar Salimi 2020 Childrens Mercy Hospital

Angiopoietin 1 Protects Against Lps-Induced Acute Lung Injury And Alveolar Remodeling In Neonatal Mice, Umar Salimi

Research Days

No abstract provided.


Acute Pneumonia, Steven C. Hatch 2020 University of Massachusetts Medical School

Acute Pneumonia, Steven C. Hatch

PEER Liberia Project

The goals of this presentation are to characterize the epidemiology and pathogenesis of acute pneumonia in children and adults; highlight the most common etiologic agents of acute pneumonia; review clinical presentation and diagnosis; and explain the approach to management.


Pneumonia: An Unexpected Graveyard Visitor?, Daniel A. Casas DO, Jigar Chauhan MD, Melanie Williams DO, Jan Sambataro MD, David Sukhai MD, Pablo G. Dubon MD, Jorge Perez MD 2020 HCA Healthcare

Pneumonia: An Unexpected Graveyard Visitor?, Daniel A. Casas Do, Jigar Chauhan Md, Melanie Williams Do, Jan Sambataro Md, David Sukhai Md, Pablo G. Dubon Md, Jorge Perez Md

West Florida Division Virtual Research Day

Community acquired pneumonia caused by Influenza can present with superinfection. On rare occasions, an unexpected organism is discovered.


Iatrogenic Pneumothorax With Subsequent Subcutaneous Emphysema, George Michael, Eric Yuschak DO, My Myers MD 2020 HCA Healthcare

Iatrogenic Pneumothorax With Subsequent Subcutaneous Emphysema, George Michael, Eric Yuschak Do, My Myers Md

West Florida Division Virtual Research Day

Lung cancer is the leading cause of cancer-related death in the United States, accounting for 13% of all new cancer diagnoses and 24% of all cancer deaths.1 Transthoracic CT-guided biopsy (CTGB) is commonly used as a diagnostic tool for lung cancer, with high diagnostic accuracy, sensitivity, and specificity. 2 This procedure, however, is not without its risks which include pulmonary hemorrhage and iatrogenic pneumothorax (IPNX). Emergent chest tube placement is standard care of treatment for massive or symptomatic IPNX, commonly with the use of smaller caliber chest tubes. 2 There is, however, a growing discussion over use of larger ...


A Case Of Medication-Induced Diffuse Alveolar Hemorrhage In Neurofibromatosis Type 1, Ashar Mahmood MD, Liz Palmer MD, Rebecca Schuyler MD, Svitlana Sharpovalova MD, Bilal Nadeem MD, Mukesh Mehta MD, Salman Muddassir MD, Nikolay Mitzov MD, Monicka S. Felix MD 2020 HCA Healthcare

A Case Of Medication-Induced Diffuse Alveolar Hemorrhage In Neurofibromatosis Type 1, Ashar Mahmood Md, Liz Palmer Md, Rebecca Schuyler Md, Svitlana Sharpovalova Md, Bilal Nadeem Md, Mukesh Mehta Md, Salman Muddassir Md, Nikolay Mitzov Md, Monicka S. Felix Md

West Florida Division Virtual Research Day

  • Amiodarone, an antiarrhythmic and apixaban, an anticoagulant have been associated with diffuse alveolar hemorrhage (DAH).
  • Cases have been documented demonstrating DAH in the setting of amiodarone and apixabantreatment, however there are few cases examining DAH in combination therapy.
  • We present a case of diffuse alveolar hemorrhage in the setting of amiodarone and apixaban treatment for paroxysmal atrial fibrillation.
  • NF1 is know to have higher risk for major bleeds due to their friable vasculature.


Acute Hypoxic Respiratory Failure Due To Organizing Pneumonia With Lipoid/Cholesterol Component Caused By Thc Vaping With E-Cigarette, Jinal K. Patel MD, Kiran Tirumalasetty MD, Jessica Khabra MD, Imran Khan MD, Johnathan Frunzi MD 2020 HCA Healthcare

Acute Hypoxic Respiratory Failure Due To Organizing Pneumonia With Lipoid/Cholesterol Component Caused By Thc Vaping With E-Cigarette, Jinal K. Patel Md, Kiran Tirumalasetty Md, Jessica Khabra Md, Imran Khan Md, Johnathan Frunzi Md

West Florida Division Virtual Research Day

Vaping has been the new and deemed “safer” way to inhale addictive chemicals such as nicotine and tetrahydrocannabinol (THC), but it does not encompass the detrimental effects of other ingredients in these vaping cartridges that can cause lung injury[1,2]. Similar studies with dabbing (heating THC wax concentrate at high temperatures with butane) showcase rapidly progressing lung injury with massive consolidation and lasting effects on lung parenchyma over a period of time [3]. This case report aims to educate people, especially the younger generation, of the dangers of newer ways of combustible alternatives that have been marketed as a ...


How Immune T-Cell Augmentation Can Help Prevent Covid-19: A Possible Nutritional Solution Using Ketogenic Lifestyle, Ravi k. Kamepalli MD,FIDSA,CWSP 2020 Regional Infectious diseases and infusion ctr,Inc

How Immune T-Cell Augmentation Can Help Prevent Covid-19: A Possible Nutritional Solution Using Ketogenic Lifestyle, Ravi K. Kamepalli Md,Fidsa,Cwsp

The University of Louisville Journal of Respiratory Infections

No abstract provided.


Modulator Therapy For Cystic Fibrosis: An Exploration Of Current Research, Jessalyn Rombocos 2020 Liberty University

Modulator Therapy For Cystic Fibrosis: An Exploration Of Current Research, Jessalyn Rombocos

Senior Honors Theses

Developing a drug therapy that addresses the root cause of cystic fibrosis (CF) by increasing CFTR protein levels has long been a research challenge. After genetic therapy failed because a suitable delivery system could not be found, researchers began searching for small organic molecules that could act as chaperones for CFTR. These molecules, known as modulators, allowed CFTR to be assembled correctly and function similarly to wild type CFTR. Since 2012, four modulator drugs have been developed, tested, and approved by the FDA. In October 2019, Trikafta was approved as the first triple-combination modulator drug and has completely revolutionized CF ...


Single-Cell Analysis Of Upper Airway Cells Reveals Host-Viral Dynamics In Influenza Infected Adults, Yuming Cao, Zhiru Guo, Pranitha Vangala, Elisa Donnard, Ping Liu, Patrick McDonel, Jose Ordovas Montanes, Alex K. Shalek, Robert W. Finberg, Jennifer P. Wang, Manuel Garber 2020 University of Massachusetts Medical School

Single-Cell Analysis Of Upper Airway Cells Reveals Host-Viral Dynamics In Influenza Infected Adults, Yuming Cao, Zhiru Guo, Pranitha Vangala, Elisa Donnard, Ping Liu, Patrick Mcdonel, Jose Ordovas Montanes, Alex K. Shalek, Robert W. Finberg, Jennifer P. Wang, Manuel Garber

University of Massachusetts Medical School Faculty Publications

Influenza virus infections are major causes of morbidity and mortality. Research using cultured cells, bulk tissue, and animal models cannot fully capture human disease dynamics. Many aspects of virus-host interactions in a natural setting remain unclear, including the specific cell types that are infected and how they and neighboring bystander cells contribute to the overall antiviral response. To address these questions, we performed single-cell RNA sequencing (scRNA-Seq) on cells from freshly collected nasal washes from healthy human donors and donors diagnosed with acute influenza during the 2017-18 season. We describe a previously uncharacterized goblet cell population, specific to infected individuals ...


Declines In Lung Function After Antiretroviral Therapy Initiation In Adults With Human Immunodeficiency Virus And Tuberculosis: A Potential Manifestation Of Respiratory Immune Reconstitution Inflammatory Syndrome, Sara C. Auld, Pholo Maenetje, Shruthi Ravimohan, Drew Weissman, Itai Ncube, Mandla Mlotshwa, Nelly Ratsela, William Chase, Mboyo-Di-Tamba Vangu, Robert Wallis, Gavin Churchyard, Hardy Kornfeld, Gregory P. Bisson 2020 Emory University

Declines In Lung Function After Antiretroviral Therapy Initiation In Adults With Human Immunodeficiency Virus And Tuberculosis: A Potential Manifestation Of Respiratory Immune Reconstitution Inflammatory Syndrome, Sara C. Auld, Pholo Maenetje, Shruthi Ravimohan, Drew Weissman, Itai Ncube, Mandla Mlotshwa, Nelly Ratsela, William Chase, Mboyo-Di-Tamba Vangu, Robert Wallis, Gavin Churchyard, Hardy Kornfeld, Gregory P. Bisson

Open Access Articles

End-organ impairment has received relatively little research attention as a possible manifestation of tuberculosis immune reconstitution inflammatory syndrome (TB-IRIS). In this prospective cohort study, one-half of adults with human immunodeficiency virus and pulmonary tuberculosis experienced meaningful declines in lung function on antiretroviral therapy, suggesting a role for lung function in TB-IRIS definitions.


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