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455 full-text articles. Page 1 of 17.

Sustained Use Of Patient Portal Features And Improvements In Diabetes Physiological Measures, Stephanie L. Shimada, Jeroan J. Allison, Amy K. Rosen, Hua Feng, Thomas K. Houston 2017 University of Massachusetts Medical School

Sustained Use Of Patient Portal Features And Improvements In Diabetes Physiological Measures, Stephanie L. Shimada, Jeroan J. Allison, Amy K. Rosen, Hua Feng, Thomas K. Houston

Jeroan J. Allison

BACKGROUND: Personal health records (PHRs) have the potential to improve patient self-management for chronic conditions such as diabetes. However, evidence is mixed as to whether there is an association between PHR use and improved health outcomes.

OBJECTIVE: The aim of this study was to evaluate the association between sustained use of specific patient portal features (Web-based prescription refill and secure messaging-SM) and physiological measures important for the management of type 2 diabetes.

METHODS: Using a retrospective cohort design, including Veterans with diabetes registered for the My Health e Vet patient portal who had not yet used the Web-based refill or ...


Data From: Predictors Of Lack Of Partial Clinical Remission In New-Onset Pediatric Type 1 Diabetes, Katherine R. Marino, Rachel L. Lundberg, Aastha Jasrotia, Louise S. Maranda, Michael J. Thompson, Bruce A. Barton, Laura C. Alonso, Benjamin U. Nwosu 2017 University of Massachusetts Medical School

Data From: Predictors Of Lack Of Partial Clinical Remission In New-Onset Pediatric Type 1 Diabetes, Katherine R. Marino, Rachel L. Lundberg, Aastha Jasrotia, Louise S. Maranda, Michael J. Thompson, Bruce A. Barton, Laura C. Alonso, Benjamin U. Nwosu

Benjamin U. Nwosu

This dataset is the primary data source for a manuscript submitted for publication.


Risk Communication, The Hanford Thyroid Disease Study And Draft Reports, Sharon M. Friedman 2017 University of New Hampshire

Risk Communication, The Hanford Thyroid Disease Study And Draft Reports, Sharon M. Friedman

RISK: Health, Safety & Environment

The author reviews the release of the draft Hanford Thyroid Disease Study as a case study in risk communication problems arising from public disclosure of draft reports.


Data From: Predictors Of Lack Of Partial Clinical Remission In New-Onset Pediatric Type 1 Diabetes, Katherine R. Marino, Rachel L. Lundberg, Aastha Jasrotia, Louise S. Maranda, Michael J. Thompson, Bruce A. Barton, Laura C. Alonso, Benjamin U. Nwosu 2017 University of Massachusetts Medical School

Data From: Predictors Of Lack Of Partial Clinical Remission In New-Onset Pediatric Type 1 Diabetes, Katherine R. Marino, Rachel L. Lundberg, Aastha Jasrotia, Louise S. Maranda, Michael J. Thompson, Bruce A. Barton, Laura C. Alonso, Benjamin U. Nwosu

Pediatric Research Data

This dataset is the primary data source for a manuscript submitted for publication.


Pcsk9 Genetic Variants And Risk Of Type 2 Diabetes: A Mendelian Randomisation Study, A. Schmidt, D. Swerdlow, M. Holmes, R. Patel, Z. Fairhurst-Hunter, Cara L. Carty, +several additional authors 2017 George Washington University

Pcsk9 Genetic Variants And Risk Of Type 2 Diabetes: A Mendelian Randomisation Study, A. Schmidt, D. Swerdlow, M. Holmes, R. Patel, Z. Fairhurst-Hunter, Cara L. Carty, +Several Additional Authors

Pediatrics Faculty Publications

BACKGROUND:

Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest hyperglycaemia, increased bodyweight, and modestly increased risk of type 2 diabetes, which in no way offsets their substantial benefits. We sought to investigate the associations of LDL cholesterol-lowering PCSK9 variants with type 2 diabetes and related biomarkers to gauge the likely effects of PCSK9 inhibitors on diabetes risk.

METHODS:

In this mendelian randomisation study, we used data from cohort studies, randomised controlled trials, case control studies, and ...


Diabetes Mellitus: Concerns, Treatment Options, And The Future, Ryan Curry 2017 Augustana College, Rock Island Illinois

Diabetes Mellitus: Concerns, Treatment Options, And The Future, Ryan Curry

Biology: Student Scholarship & Creative Works

Diabetes is a serious disease that is becoming very serious worldwide. This review will discuss some of the treatment options that are available for type two diabetes with a comparison to insulin management. It will discuss the history, genetics, economics, and also the future of diabetes management.


The Rodent Parvovirus H-1 And Its Potential In Combination With Tien Hsien Liquid As A Treatment For Breast Cancer, Hayley I. Spires 2016 Southeastern University - Lakeland

The Rodent Parvovirus H-1 And Its Potential In Combination With Tien Hsien Liquid As A Treatment For Breast Cancer, Hayley I. Spires

Selected Honors Theses

Breast cancer is responsible for 12% of cancer diagnoses each year, and it is the leading cause of cancer-related mortality in women worldwide. Current treatments have provided some success in combatting the disease but are not considered a final solution. The framework for how researchers approach cancer has continued to change, and this includes the introduction of oncolytic viruses as novel therapeutics for cancer. The rodent parvovirus H-1 has shown strong potential in clinical and subclinical trials, but its S phase dependency limits its usefulness against cancer stem cell populations. Tien Hsien Liquid is commerically available, nontoxic, and has shown ...


Evaluating Acceptability, Feasibility And Efficacy Of A Diabetes Care Support Program Facilitated By Cellular-Enabled Glucose Meters: A Dissertation, Daniel J. Amante 2016 University of Massachusetts Medical School

Evaluating Acceptability, Feasibility And Efficacy Of A Diabetes Care Support Program Facilitated By Cellular-Enabled Glucose Meters: A Dissertation, Daniel J. Amante

GSBS Dissertations and Theses

Background. Diabetes requires significant disease management, patient-provider communication, and interaction between patients, family members, caregivers, and care teams. Emerging patient-facing technologies, such as cellular-enabled glucose meters, can facilitate additional care support and improve diabetes self-management. This study evaluated patient acceptability, feasibility, and efficacy of a diabetes care support program facilitated by cellular-enabled glucose meters.

Methods. A two-phase study approach was taken. Get In Touch – Phase 1 (GIT-1) was a 1-month pilot involving patients with type 1 and type 2 diabetes. Get In Touch – Phase 2 (GIT-2) was a 12-month randomized controlled crossover trial involving patients with poorly-controlled type 2 diabetes ...


Acceptability And Feasibility Of Web-Based Diabetes Instruction For Latinos With Limited Education And Computer Experience, Sharon A. Fitzgerald, Victor E. Martinez-Zavala, Kenia Yazmin Reyna Blanco, A Paula Cupertino, Mugur V. Geana, Edward F. Ellerbeck 2016 University of Kansas Medical Center

Acceptability And Feasibility Of Web-Based Diabetes Instruction For Latinos With Limited Education And Computer Experience, Sharon A. Fitzgerald, Victor E. Martinez-Zavala, Kenia Yazmin Reyna Blanco, A Paula Cupertino, Mugur V. Geana, Edward F. Ellerbeck

Journal of Health Disparities Research and Practice

Introduction: The internet offers an important avenue for developing diabetes self-management skills, but many Latinos have limited experience with computer-based instruction.

Objective: To evaluate the feasibility and acceptability of delivering a web-based diabetes education program in a computer classroom for Spanish-speaking Latinos.

Methods: Spanish-speaking Latinos (n=26) attended two classroom sessions to learn computer skills while navigating a web-based diabetes education platform. Diabetes knowledge was assessed before and after the intervention; structured interviews were completed to assess program acceptability.

Results: Half of participants (50%) had not previously used a computer. Post-intervention, diabetes knowledge improved significantly (p=.001). The majority of ...


The Current Treatment Of Erectile Dysfunction, Maria Isabela Sarbu, Mircea Tampa, Mădălina I. Mitran, Cristina I. Mitran, Vasile Benea, Simona R. Georgescu 2016 Carol Davila University, Department of Dermatology and Venereology

The Current Treatment Of Erectile Dysfunction, Maria Isabela Sarbu, Mircea Tampa, Mădălina I. Mitran, Cristina I. Mitran, Vasile Benea, Simona R. Georgescu

Journal of Mind and Medical Sciences

Erectile dysfunction (ED) is the inability to achieve and maintain an erection sufficient for satisfactory sexual intercourse. It is the most frequent sexual dysfunction in elderly men and its prevalence increases with age.

Ever since ED was recognized as a real health problem, several treatment options became available and some of them proved to be very efficient. PDE5 inhibitors are the mainstay treatment of ED.

However, other treatment options such as intracorporal injections, surgery, vacuum devices and prosthesis are also available for patients who are unresponsive to PDE5 inhibitors. Since none of the treatment options available so far has proven ...


The Postfinasteride Syndrome; An Overview, David L. Rowland, Ion G. Motofei, Florian Popa, Vlad D. Constantin, Adriana Vasilache, Ioana Păunică, Cristian Bălălău, Georgeta P. Păunică, Petrisor Banu, Stana Păunică 2016 Valparaiso University, Department of Psychology

The Postfinasteride Syndrome; An Overview, David L. Rowland, Ion G. Motofei, Florian Popa, Vlad D. Constantin, Adriana Vasilache, Ioana Păunică, Cristian Bălălău, Georgeta P. Păunică, Petrisor Banu, Stana Păunică

Journal of Mind and Medical Sciences

As a 5-α reductase inhibitor, Finasteride has proven effective in ameliorating two conditions documented to be androgen dependent, namely male androgenic alopecia and benign prostatic hyperplasia. Therapeutic results are maintained as long as the drug is administered, with treatment cessation generally leading to the return of symptomatology for each condition. In addition, during the therapeutic phase, several adverse effects have been reported, some of which persist long or indefinitely after treatment cessation, known as “post-finasteride syndrome.”

Herein we present and discuss the most common finasteride side effects, along with a psycho-neuroendocrine rationale that could explain the persistence of many adverse ...


Validation Of A Metabolite Panel For Early Diagnosis Of Type 2 Diabetes, Steven J. Schrodi 2016 Marshfield Clinic Research Foundation

Validation Of A Metabolite Panel For Early Diagnosis Of Type 2 Diabetes, Steven J. Schrodi

Steven J Schrodi

Background. Accurate, early diagnosis of type 2 diabetes (T2D) would enable more
effective clinical management and a reduction in T2D complications. Therefore, we sought
to identify plasma metabolite and protein biomarkers that, in combination with glucose,
can better predict future T2D compared with glucose alone.
Methods. In this case–control study, we used plasma samples from the Bavarian Red
Cross Blood Transfusion Center study (61 T2D cases and 78 non-diabetic controls) for
discovering T2D-associated metabolites, and plasma samples from the Personalized
Medicine Research Project in Wisconsin (56 T2D cases and 445 non-diabetic controls) for
validation. All samples were obtained before ...


Validation Of A Metabolite Panel For Early Diagnosis Of Type 2 Diabetes, Steven J. Schrodi 2016 Marshfield Clinic Research Foundation

Validation Of A Metabolite Panel For Early Diagnosis Of Type 2 Diabetes, Steven J. Schrodi

Steven J Schrodi

Background. Accurate, early diagnosis of type 2 diabetes (T2D) would enable more
effective clinical management and a reduction in T2D complications. Therefore, we sought
to identify plasma metabolite and protein biomarkers that, in combination with glucose,
can better predict future T2D compared with glucose alone.
Methods. In this case–control study, we used plasma samples from the Bavarian Red
Cross Blood Transfusion Center study (61 T2D cases and 78 non-diabetic controls) for
discovering T2D-associated metabolites, and plasma samples from the Personalized
Medicine Research Project in Wisconsin (56 T2D cases and 445 non-diabetic controls) for
validation. All samples were obtained before ...


Validation Of A Metabolite Panel For Early Diagnosis Of Type 2 Diabetes, Steven J. Schrodi 2016 Marshfield Clinic Research Foundation

Validation Of A Metabolite Panel For Early Diagnosis Of Type 2 Diabetes, Steven J. Schrodi

Steven J Schrodi

Background. Accurate, early diagnosis of type 2 diabetes (T2D) would enable more
effective clinical management and a reduction in T2D complications. Therefore, we sought
to identify plasma metabolite and protein biomarkers that, in combination with glucose,
can better predict future T2D compared with glucose alone.
Methods. In this case–control study, we used plasma samples from the Bavarian Red
Cross Blood Transfusion Center study (61 T2D cases and 78 non-diabetic controls) for
discovering T2D-associated metabolites, and plasma samples from the Personalized
Medicine Research Project in Wisconsin (56 T2D cases and 445 non-diabetic controls) for
validation. All samples were obtained before ...


Validation Of A Metabolite Panel For Early Diagnosis Of Type 2 Diabetes, Steven J. Schrodi 2016 Marshfield Clinic Research Foundation

Validation Of A Metabolite Panel For Early Diagnosis Of Type 2 Diabetes, Steven J. Schrodi

Steven J Schrodi

Background. Accurate, early diagnosis of type 2 diabetes (T2D) would enable more
effective clinical management and a reduction in T2D complications. Therefore, we sought
to identify plasma metabolite and protein biomarkers that, in combination with glucose,
can better predict future T2D compared with glucose alone.
Methods. In this case–control study, we used plasma samples from the Bavarian Red
Cross Blood Transfusion Center study (61 T2D cases and 78 non-diabetic controls) for
discovering T2D-associated metabolites, and plasma samples from the Personalized
Medicine Research Project in Wisconsin (56 T2D cases and 445 non-diabetic controls) for
validation. All samples were obtained before ...


Validation Of A Metabolite Panel For Early Diagnosis Of Type 2 Diabetes, Steven J. Schrodi 2016 Marshfield Clinic Research Foundation

Validation Of A Metabolite Panel For Early Diagnosis Of Type 2 Diabetes, Steven J. Schrodi

Steven J Schrodi

Background. Accurate, early diagnosis of type 2 diabetes (T2D) would enable more
effective clinical management and a reduction in T2D complications. Therefore, we sought
to identify plasma metabolite and protein biomarkers that, in combination with glucose,
can better predict future T2D compared with glucose alone.
Methods. In this case–control study, we used plasma samples from the Bavarian Red
Cross Blood Transfusion Center study (61 T2D cases and 78 non-diabetic controls) for
discovering T2D-associated metabolites, and plasma samples from the Personalized
Medicine Research Project in Wisconsin (56 T2D cases and 445 non-diabetic controls) for
validation. All samples were obtained before ...


Validation Of A Metabolite Panel For Early Diagnosis Of Type 2 Diabetes, Steven J. Schrodi 2016 Marshfield Clinic Research Foundation

Validation Of A Metabolite Panel For Early Diagnosis Of Type 2 Diabetes, Steven J. Schrodi

Steven J Schrodi

Background. Accurate, early diagnosis of type 2 diabetes (T2D) would enable more
effective clinical management and a reduction in T2D complications. Therefore, we sought
to identify plasma metabolite and protein biomarkers that, in combination with glucose,
can better predict future T2D compared with glucose alone.
Methods. In this case–control study, we used plasma samples from the Bavarian Red
Cross Blood Transfusion Center study (61 T2D cases and 78 non-diabetic controls) for
discovering T2D-associated metabolites, and plasma samples from the Personalized
Medicine Research Project in Wisconsin (56 T2D cases and 445 non-diabetic controls) for
validation. All samples were obtained before ...


Validation Of A Metabolite Panel For Early Diagnosis Of Type 2 Diabetes, Steven J. Schrodi 2016 Marshfield Clinic Research Foundation

Validation Of A Metabolite Panel For Early Diagnosis Of Type 2 Diabetes, Steven J. Schrodi

Steven J Schrodi

Background. Accurate, early diagnosis of type 2 diabetes (T2D) would enable more
effective clinical management and a reduction in T2D complications. Therefore, we sought
to identify plasma metabolite and protein biomarkers that, in combination with glucose,
can better predict future T2D compared with glucose alone.
Methods. In this case–control study, we used plasma samples from the Bavarian Red
Cross Blood Transfusion Center study (61 T2D cases and 78 non-diabetic controls) for
discovering T2D-associated metabolites, and plasma samples from the Personalized
Medicine Research Project in Wisconsin (56 T2D cases and 445 non-diabetic controls) for
validation. All samples were obtained before ...


Validation Of A Metabolite Panel For Early Diagnosis Of Type 2 Diabetes, Steven J. Schrodi 2016 Marshfield Clinic Research Foundation

Validation Of A Metabolite Panel For Early Diagnosis Of Type 2 Diabetes, Steven J. Schrodi

Steven J Schrodi

Background. Accurate, early diagnosis of type 2 diabetes (T2D) would enable more
effective clinical management and a reduction in T2D complications. Therefore, we sought
to identify plasma metabolite and protein biomarkers that, in combination with glucose,
can better predict future T2D compared with glucose alone.
Methods. In this case–control study, we used plasma samples from the Bavarian Red
Cross Blood Transfusion Center study (61 T2D cases and 78 non-diabetic controls) for
discovering T2D-associated metabolites, and plasma samples from the Personalized
Medicine Research Project in Wisconsin (56 T2D cases and 445 non-diabetic controls) for
validation. All samples were obtained before ...


Regulation Of Polycystin-1 Function By Calmodulin Binding, Nicholas Doerr, Yidi Wang, Kevin R. Kipp, Guangyi Liu, Jesse J. Benza, Vladimir Pletnev, Tengis S. Pavlov, Alexander Staruschenko, Ashraf M. Mohieldin, Maki Takahashi, Surya M. Nauli, Thomas Weimbs 2016 University of California, Santa Barbara

Regulation Of Polycystin-1 Function By Calmodulin Binding, Nicholas Doerr, Yidi Wang, Kevin R. Kipp, Guangyi Liu, Jesse J. Benza, Vladimir Pletnev, Tengis S. Pavlov, Alexander Staruschenko, Ashraf M. Mohieldin, Maki Takahashi, Surya M. Nauli, Thomas Weimbs

Pharmacy Faculty Articles and Research

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common genetic disease that leads to progressive renal cyst growth and loss of renal function, and is caused by mutations in the genes encoding polycystin-1 (PC1) and polycystin-2 (PC2), respectively. The PC1/PC2 complex localizes to primary cilia and can act as a flow-dependent calcium channel in addition to numerous other signaling functions. The exact functions of the polycystins, their regulation and the purpose of the PC1/PC2 channel are still poorly understood. PC1 is an integral membrane protein with a large extracytoplasmic N-terminal domain and a short, ~200 amino acid C-terminal ...


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