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Positioning Of Patients For Pelvic Radiation: Variability Across Treatment, Mashhood Ahmad Bodla, Alexander Lukez, Lauren O'Loughlin, Jennifer Baima, Janaki Moni 2018 University of Massachusetts Medical School

Positioning Of Patients For Pelvic Radiation: Variability Across Treatment, Mashhood Ahmad Bodla, Alexander Lukez, Lauren O'Loughlin, Jennifer Baima, Janaki Moni

Orthopedics and Physical Rehabilitation Publications and Presentations

Objectives: We aimed to determine the variability in position of the pelvis for patients while receiving daily radiation treatments for pelvic malignancies.

Design: Therapeutic radiation targets lymph nodes that lie along the curvature of the sacrum. Any change in pelvic tilt could inadvertently move these targets in or out of the radiation field. This variability has clinical significance both to target cancerous lymph nodes and avoid healthy sacrum.

To better understand this variability, we observed trends in the change in the sacral slope. This measurement was chosen because it is an objective radiographic finding, there is no significant difference between ...


The Association Of Dietary Quality With Colorectal Cancer Among Normal Weight, Overweight And Obese Men And Women: A Prospective Longitudinal Study In The Usa, Rosalie A. Torres Stone, Molly E. Waring, Sarah L. Cutrona, Catarina I. Kiefe, Jeroan J. Allison, Chyke A. Doubeni 2018 University of Massachusetts Medical School

The Association Of Dietary Quality With Colorectal Cancer Among Normal Weight, Overweight And Obese Men And Women: A Prospective Longitudinal Study In The Usa, Rosalie A. Torres Stone, Molly E. Waring, Sarah L. Cutrona, Catarina I. Kiefe, Jeroan J. Allison, Chyke A. Doubeni

Jeroan J. Allison

OBJECTIVE: Lower body mass index (BMI) and higher dietary quality reduce the risk of colorectal cancer (CRC). A full understanding of how these associations vary by sex and weight is lacking.

METHODS: We used data from the National Institutes of Health - American Association of Retired Persons (NIH)-AARP) Diet and Health Study for 398 458 persons who were 50-71 years old in 1995-1996 and followed through 2006. Exposures were dietary quality as reflected by the Mediterranean Diet, the Healthy Eating Index-2010 and the Dietary Approaches to Stop Hypertension score, stratified by BMI category. The outcome was CRC diagnosis from cancer ...


The Association Of Dietary Quality With Colorectal Cancer Among Normal Weight, Overweight And Obese Men And Women: A Prospective Longitudinal Study In The Usa, Rosalie A. Torres Stone, Molly E. Waring, Sarah L. Cutrona, Catarina I. Kiefe, Jeroan J. Allison, Chyke A. Doubeni 2018 University of Massachusetts Medical School

The Association Of Dietary Quality With Colorectal Cancer Among Normal Weight, Overweight And Obese Men And Women: A Prospective Longitudinal Study In The Usa, Rosalie A. Torres Stone, Molly E. Waring, Sarah L. Cutrona, Catarina I. Kiefe, Jeroan J. Allison, Chyke A. Doubeni

Sarah L. Cutrona

OBJECTIVE: Lower body mass index (BMI) and higher dietary quality reduce the risk of colorectal cancer (CRC). A full understanding of how these associations vary by sex and weight is lacking.

METHODS: We used data from the National Institutes of Health - American Association of Retired Persons (NIH)-AARP) Diet and Health Study for 398 458 persons who were 50-71 years old in 1995-1996 and followed through 2006. Exposures were dietary quality as reflected by the Mediterranean Diet, the Healthy Eating Index-2010 and the Dietary Approaches to Stop Hypertension score, stratified by BMI category. The outcome was CRC diagnosis from cancer ...


The Association Of Dietary Quality With Colorectal Cancer Among Normal Weight, Overweight And Obese Men And Women: A Prospective Longitudinal Study In The Usa, Rosalie A. Torres Stone, Molly E. Waring, Sarah L. Cutrona, Catarina I. Kiefe, Jeroan J. Allison, Chyke A. Doubeni 2018 University of Massachusetts Medical School

The Association Of Dietary Quality With Colorectal Cancer Among Normal Weight, Overweight And Obese Men And Women: A Prospective Longitudinal Study In The Usa, Rosalie A. Torres Stone, Molly E. Waring, Sarah L. Cutrona, Catarina I. Kiefe, Jeroan J. Allison, Chyke A. Doubeni

Rosalie A. Torres Stone

OBJECTIVE: Lower body mass index (BMI) and higher dietary quality reduce the risk of colorectal cancer (CRC). A full understanding of how these associations vary by sex and weight is lacking.

METHODS: We used data from the National Institutes of Health - American Association of Retired Persons (NIH)-AARP) Diet and Health Study for 398 458 persons who were 50-71 years old in 1995-1996 and followed through 2006. Exposures were dietary quality as reflected by the Mediterranean Diet, the Healthy Eating Index-2010 and the Dietary Approaches to Stop Hypertension score, stratified by BMI category. The outcome was CRC diagnosis from cancer ...


The Association Of Dietary Quality With Colorectal Cancer Among Normal Weight, Overweight And Obese Men And Women: A Prospective Longitudinal Study In The Usa, Rosalie A. Torres Stone, Molly E. Waring, Sarah L. Cutrona, Catarina I. Kiefe, Jeroan J. Allison, Chyke A. Doubeni 2018 University of Massachusetts Medical School

The Association Of Dietary Quality With Colorectal Cancer Among Normal Weight, Overweight And Obese Men And Women: A Prospective Longitudinal Study In The Usa, Rosalie A. Torres Stone, Molly E. Waring, Sarah L. Cutrona, Catarina I. Kiefe, Jeroan J. Allison, Chyke A. Doubeni

Catarina I. Kiefe

OBJECTIVE: Lower body mass index (BMI) and higher dietary quality reduce the risk of colorectal cancer (CRC). A full understanding of how these associations vary by sex and weight is lacking. METHODS: We used data from the National Institutes of Health - American Association of Retired Persons (NIH)-AARP) Diet and Health Study for 398 458 persons who were 50-71 years old in 1995-1996 and followed through 2006. Exposures were dietary quality as reflected by the Mediterranean Diet, the Healthy Eating Index-2010 and the Dietary Approaches to Stop Hypertension score, stratified by BMI category. The outcome was CRC diagnosis from cancer ...


Real-World Usage And Clinical Outcomes Of Alectinib Among Post-Crizotinib Progression Anaplastic Lymphoma Kinase Positive Non-Small-Cell Lung Cancer Patients In The Usa, Marco D. DiBonaventura, William Wong, Bijal M. Shah-Manek, Mathias Schulz 2018 Touro University California

Real-World Usage And Clinical Outcomes Of Alectinib Among Post-Crizotinib Progression Anaplastic Lymphoma Kinase Positive Non-Small-Cell Lung Cancer Patients In The Usa, Marco D. Dibonaventura, William Wong, Bijal M. Shah-Manek, Mathias Schulz

College of Pharmacy (TUC) Publications and Research

Background: Alectinib is an approved treatment for anaplastic lymphoma kinase (ALK)-positive patients with advanced non-small-cell lung cancer. Despite positive supporting clinical data, there is a lack of real-world information on the usage and patient outcomes of those treated with alectinib post-crizotinib progression.

Methods: Participating oncologists (N=95) in the USA were recruited from an online physician panel to participate in a retrospective patient chart review. Physicians randomly selected eligible patients (ie, patients who progressed on crizotinib as their first ALK inhibitor and were treated with alectinib as their second ALK inhibitor), collected demographics and clinical history from their medical ...


The Role Of Tgf-Β/Smad4 Signaling In Cancer, M Zhao, Lopa Mishra, C Deng 2018 George Washington University

The Role Of Tgf-Β/Smad4 Signaling In Cancer, M Zhao, Lopa Mishra, C Deng

Surgery Faculty Publications

Transforming growth factor β (TGF-β) signaling pathway plays important roles in many biological processes, including cell growth, differentiation, apoptosis, migration, as well as cancer initiation and progression. SMAD4, which serves as the central mediator of TGF-β signaling, is specifically inactivated in over half of pancreatic duct adenocarcinoma, and varying degrees in many other types of cancers. In the past two decades, multiple studies have revealed that SMAD4 loss on its own does not initiate tumor formation, but can promote tumor progression initiated by other genes, such as KRAS activation in pancreatic duct adenocarcinoma and APC inactivation in colorectal cancer. In ...


The Association Of Dietary Quality With Colorectal Cancer Among Normal Weight, Overweight And Obese Men And Women: A Prospective Longitudinal Study In The Usa, Rosalie A. Torres Stone, Molly E. Waring, Sarah L. Cutrona, Catarina I. Kiefe, Jeroan J. Allison, Chyke A. Doubeni 2017 University of Massachusetts Medical School

The Association Of Dietary Quality With Colorectal Cancer Among Normal Weight, Overweight And Obese Men And Women: A Prospective Longitudinal Study In The Usa, Rosalie A. Torres Stone, Molly E. Waring, Sarah L. Cutrona, Catarina I. Kiefe, Jeroan J. Allison, Chyke A. Doubeni

Rosalie A. Torres Stone

OBJECTIVE: Lower body mass index (BMI) and higher dietary quality reduce the risk of colorectal cancer (CRC). A full understanding of how these associations vary by sex and weight is lacking.

METHODS: We used data from the National Institutes of Health - American Association of Retired Persons (NIH)-AARP) Diet and Health Study for 398 458 persons who were 50-71 years old in 1995-1996 and followed through 2006. Exposures were dietary quality as reflected by the Mediterranean Diet, the Healthy Eating Index-2010 and the Dietary Approaches to Stop Hypertension score, stratified by BMI category. The outcome was CRC diagnosis from cancer ...


The Association Of Dietary Quality With Colorectal Cancer Among Normal Weight, Overweight And Obese Men And Women: A Prospective Longitudinal Study In The Usa, Rosalie A. Torres Stone, Molly E. Waring, Sarah L. Cutrona, Catarina I. Kiefe, Jeroan J. Allison, Chyke A. Doubeni 2017 University of Massachusetts Medical School

The Association Of Dietary Quality With Colorectal Cancer Among Normal Weight, Overweight And Obese Men And Women: A Prospective Longitudinal Study In The Usa, Rosalie A. Torres Stone, Molly E. Waring, Sarah L. Cutrona, Catarina I. Kiefe, Jeroan J. Allison, Chyke A. Doubeni

Jeroan J. Allison

OBJECTIVE: Lower body mass index (BMI) and higher dietary quality reduce the risk of colorectal cancer (CRC). A full understanding of how these associations vary by sex and weight is lacking.

METHODS: We used data from the National Institutes of Health - American Association of Retired Persons (NIH)-AARP) Diet and Health Study for 398 458 persons who were 50-71 years old in 1995-1996 and followed through 2006. Exposures were dietary quality as reflected by the Mediterranean Diet, the Healthy Eating Index-2010 and the Dietary Approaches to Stop Hypertension score, stratified by BMI category. The outcome was CRC diagnosis from cancer ...


The Association Of Dietary Quality With Colorectal Cancer Among Normal Weight, Overweight And Obese Men And Women: A Prospective Longitudinal Study In The Usa, Rosalie A. Torres Stone, Molly E. Waring, Sarah L. Cutrona, Catarina I. Kiefe, Jeroan J. Allison, Chyke A. Doubeni 2017 University of Massachusetts Medical School

The Association Of Dietary Quality With Colorectal Cancer Among Normal Weight, Overweight And Obese Men And Women: A Prospective Longitudinal Study In The Usa, Rosalie A. Torres Stone, Molly E. Waring, Sarah L. Cutrona, Catarina I. Kiefe, Jeroan J. Allison, Chyke A. Doubeni

Sarah L. Cutrona

OBJECTIVE: Lower body mass index (BMI) and higher dietary quality reduce the risk of colorectal cancer (CRC). A full understanding of how these associations vary by sex and weight is lacking. METHODS: We used data from the National Institutes of Health - American Association of Retired Persons (NIH)-AARP) Diet and Health Study for 398 458 persons who were 50-71 years old in 1995-1996 and followed through 2006. Exposures were dietary quality as reflected by the Mediterranean Diet, the Healthy Eating Index-2010 and the Dietary Approaches to Stop Hypertension score, stratified by BMI category. The outcome was CRC diagnosis from cancer ...


The Association Of Dietary Quality With Colorectal Cancer Among Normal Weight, Overweight And Obese Men And Women: A Prospective Longitudinal Study In The Usa, Rosalie A. Torres Stone, Molly E. Waring, Sarah L. Cutrona, Catarina I. Kiefe, Jeroan J. Allison, Chyke A. Doubeni 2017 University of Massachusetts Medical School

The Association Of Dietary Quality With Colorectal Cancer Among Normal Weight, Overweight And Obese Men And Women: A Prospective Longitudinal Study In The Usa, Rosalie A. Torres Stone, Molly E. Waring, Sarah L. Cutrona, Catarina I. Kiefe, Jeroan J. Allison, Chyke A. Doubeni

Catarina I. Kiefe

OBJECTIVE: Lower body mass index (BMI) and higher dietary quality reduce the risk of colorectal cancer (CRC). A full understanding of how these associations vary by sex and weight is lacking. METHODS: We used data from the National Institutes of Health - American Association of Retired Persons (NIH)-AARP) Diet and Health Study for 398 458 persons who were 50-71 years old in 1995-1996 and followed through 2006. Exposures were dietary quality as reflected by the Mediterranean Diet, the Healthy Eating Index-2010 and the Dietary Approaches to Stop Hypertension score, stratified by BMI category. The outcome was CRC diagnosis from cancer ...


Cancer Survivorship: Promoting A Lifetime Of Health, Janelle Coleman-Smith 2017 The University of San Francisco

Cancer Survivorship: Promoting A Lifetime Of Health, Janelle Coleman-Smith

Master's Projects and Capstones

Abstract

Introduction Cancer survivors can face post-cancer treatment effects that need addressing throughout their care trajectory. Education provided to stakeholders and patients will be beneficial in preventing fragmented care, increasing patient satisfaction, and expanding ongoing supportive clinical survivorship care. Methods An adapted Dr. Joanne Lester survivorship needs survey was given to n=7 post-cancer treatment patients within a northern California cancer patient advisory committee. The survey results were analyzed to identify common underserved chronic long-term survivorship needs. Based on the data, an evidence-based educational component was included within a booklet to enhance future survivorship care. Additional surveys were sent to ...


Integrative Microrna And Mrna Deep-Sequencing Expression Profiling In Endemic Burkitt Lymphoma, Cliff I. Oduor, Yasin Kaymaz, Kiprotich Chelimo, Juliana A. Otieno, John Michael Ong'echa, Ann M. Moormann, Jeffrey A. Bailey 2017 Maseno University

Integrative Microrna And Mrna Deep-Sequencing Expression Profiling In Endemic Burkitt Lymphoma, Cliff I. Oduor, Yasin Kaymaz, Kiprotich Chelimo, Juliana A. Otieno, John Michael Ong'echa, Ann M. Moormann, Jeffrey A. Bailey

Ann M. Moormann

BACKGROUND: Burkitt lymphoma (BL) is characterized by overexpression of the c-myc oncogene, which in the vast majority of cases is a consequence of an IGH/MYC translocation. While myc is the seminal event, BL is a complex amalgam of genetic and epigenetic changes causing dysregulation of both coding and non-coding transcripts. Emerging evidence suggest that abnormal modulation of mRNA transcription via miRNAs might be a significant factor in lymphomagenesis. However, the alterations in these miRNAs and their correlations to their putative mRNA targets have not been extensively studied relative to normal germinal center (GC) B cells.

METHODS: Using more sensitive ...


Transcriptional Alterations In Hereditary And Sporadic Nonfunctioning Pancreatic Neuroendocrine Tumors According To Genotype., Xavier M Keutgen, Suresh Kumar, Sudheer Gara, Myriem Boufraqech, Sunita Agarwal, Ralph H Hruban, Naris Nilubol, Martha Quezado, Richard Finney, Maggie Cam, Electron Kebebew 2017 George Washington University

Transcriptional Alterations In Hereditary And Sporadic Nonfunctioning Pancreatic Neuroendocrine Tumors According To Genotype., Xavier M Keutgen, Suresh Kumar, Sudheer Gara, Myriem Boufraqech, Sunita Agarwal, Ralph H Hruban, Naris Nilubol, Martha Quezado, Richard Finney, Maggie Cam, Electron Kebebew

Surgery Faculty Publications

BACKGROUND

Nonfunctioning pancreatic neuroendocrine tumors (NFPanNETs) may be sporadic or inherited because of germline mutations associated with von Hippel-Lindau disease (VHL) or multiple endocrine neoplasia type 1 (MEN1). The clinical behavior of NFPanNETs is difficult to predict, even in tumors of the same stage and grade. The authors analyzed genotype-specific patterns of transcriptional messenger RNA (mRNA) levels of NFPanNETs to understand the molecular features that determine PanNET phenotype.

METHODS

Thirty-two samples were included for genome-wide mRNA gene expression analysis (9 VHL-associated, 10 MEN1-associated, and 9 sporadic NFPanNETs and 4 purified normal islet cell [NIC] samples). Validation of genes was performed ...


Integrative Microrna And Mrna Deep-Sequencing Expression Profiling In Endemic Burkitt Lymphoma, Cliff I. Oduor, Yasin Kaymaz, Kiprotich Chelimo, Juliana A. Otieno, John Michael Ong'echa, Ann M. Moormann, Jeffrey A. Bailey 2017 Maseno University

Integrative Microrna And Mrna Deep-Sequencing Expression Profiling In Endemic Burkitt Lymphoma, Cliff I. Oduor, Yasin Kaymaz, Kiprotich Chelimo, Juliana A. Otieno, John Michael Ong'echa, Ann M. Moormann, Jeffrey A. Bailey

UMass Center for Clinical and Translational Science Supported Publications

BACKGROUND: Burkitt lymphoma (BL) is characterized by overexpression of the c-myc oncogene, which in the vast majority of cases is a consequence of an IGH/MYC translocation. While myc is the seminal event, BL is a complex amalgam of genetic and epigenetic changes causing dysregulation of both coding and non-coding transcripts. Emerging evidence suggest that abnormal modulation of mRNA transcription via miRNAs might be a significant factor in lymphomagenesis. However, the alterations in these miRNAs and their correlations to their putative mRNA targets have not been extensively studied relative to normal germinal center (GC) B cells.

METHODS: Using more sensitive ...


Generation Of A Patient-Derived Brain Metastasis Breast Cancer Cell Line Via Novel Orthotopic Injection Placement And Serial Mouse Transplantation To Develop Pdx Mouse Model, Amber L. LaCrosse, Denise M. Coley, Paul J. Mintz, Santhi D. Konduri, Richard A. Rovin, Amin B. Kassam 2017 Aurora Research Institute

Generation Of A Patient-Derived Brain Metastasis Breast Cancer Cell Line Via Novel Orthotopic Injection Placement And Serial Mouse Transplantation To Develop Pdx Mouse Model, Amber L. Lacrosse, Denise M. Coley, Paul J. Mintz, Santhi D. Konduri, Richard A. Rovin, Amin B. Kassam

Journal of Patient-Centered Research and Reviews

Background: The incidence of brain metastasis appears to be increasing, potentially due to advanced technology that aids early diagnosis. Patient-derived xenografts (PDX) have high translational value, as these models retain key functional characteristics of the patient tumor. PDX models are useful to understand the molecular basis of tumorigenesis and to identify new treatment targets. However, generating a first-line PDX model is challenging as engraftment failure is high. Serial transplanting tumor tissue via mouse-to-mouse propagation increases engraftment rates and decreases PDX development time. Herein we report methods to generate a PDX cell line from patient-derived tumor tissue that includes the cerebral ...


Thyroid Cancer: Is It All In The Genes?, Electron Kebebew 2017 George Washington University

Thyroid Cancer: Is It All In The Genes?, Electron Kebebew

Surgery Faculty Publications

No abstract provided.


Geographic Disparities In The Distribution Of The U.S. Gynecologic Oncology Workforce: A Society Of Gynecologic Oncology Study, Stephanie Ricci, Ana Tergas, Kara Roche, Melissa Fairbairn, Kimberly Levinson, Micael Lopez-Acevedo, +several additional authors 2017 George Washington University

Geographic Disparities In The Distribution Of The U.S. Gynecologic Oncology Workforce: A Society Of Gynecologic Oncology Study, Stephanie Ricci, Ana Tergas, Kara Roche, Melissa Fairbairn, Kimberly Levinson, Micael Lopez-Acevedo, +Several Additional Authors

Obstetrics and Gynecology Faculty Publications

A recent ASCO workforce study projects a significant shortage of oncologists in the U.S. by 2020, especially in rural/underserved (R/US) areas. The current study aim was to determine the patterns of distribution of U.S. gynecologic oncologists (GO) and to identify provider-based attitudes and barriers that may prevent GOs from practicing in R/US regions. U.S. GOs (n = 743) were electronically solicited to participate in an on-line survey regarding geographic distribution and participation in outreach care. A total of 320 GOs (43%) responded; median age range was 35–45 years and 57% were male. Most practiced ...


Re:Align, George Washington University Cancer Center 2017 Himmelfarb Health Sciences Library, The George Washington University

Re:Align, George Washington University Cancer Center

RE:

No abstract provided.


Supporting Cancer Knowledge Needs Using Online Information, Catherine W. Carr, Maryann Bishop-Jodoin, Richard S. Pieters 2017 University of Massachusetts Medical School

Supporting Cancer Knowledge Needs Using Online Information, Catherine W. Carr, Maryann Bishop-Jodoin, Richard S. Pieters

Cancer Concepts: A Guidebook for the Non-Oncologist

Information is exploding at an exponential rate. Because there is a flood of medical information on the Internet, it can be difficult to wade through the many resources to determine what information is best to use in practice. The intent of this chapter in Cancer Concepts: A Guidebook for the Non-Oncologist is to help the health care provider find reliable online cancer information. To help inform clinical decision making, health science librarians continue to address this rapidly growing body of literature by analyzing resources and identifying the highest quality information available on the Internet.

The concept of Evidence-Based Medicine (EBM ...


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