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Supporting Cancer Knowledge Needs Using Online Information, Catherine W. Carr, Maryann Bishop-Jodoin, Richard S. Pieters 2017 University of Massachusetts Medical School

Supporting Cancer Knowledge Needs Using Online Information, Catherine W. Carr, Maryann Bishop-Jodoin, Richard S. Pieters

Cancer Concepts: A Guidebook for the Non-Oncologist

Information is exploding at an exponential rate. Because there is a flood of medical information on the Internet, it can be difficult to wade through the many resources to determine what information is best to use in practice. The intent of this chapter in Cancer Concepts: A Guidebook for the Non-Oncologist is to help the health care provider find reliable online cancer information. To help inform clinical decision making, health science librarians continue to address this rapidly growing body of literature by analyzing resources and identifying the highest quality information available on the Internet.

The concept of Evidence-Based Medicine (EBM ...


Bronchial Carcinoid Presenting As Multiple Lung Abscesses, Zeeshan Waheed, Muhammad Irfan, Saulat Fatimi, Ruqaiya Shahid 2017 Aga Khan University

Bronchial Carcinoid Presenting As Multiple Lung Abscesses, Zeeshan Waheed, Muhammad Irfan, Saulat Fatimi, Ruqaiya Shahid

Saulat Fatimi

Bronchial carcinoid tumours is a rare group of pulmonary malignant neoplasm that is derived from neuroendocrine system. Bronchial carcinoid usually present with hilar masses, atelactasis, bronchiectasis, or post-obstructive pneumonia. This case describes a very unusual presentation of bronchial carcinoid tumour with multiple lung abscesses involving the whole lung. This report is of an adult lady who presented with multiple lung abscesses involving her whole of the right lung. She was found to have an endo-bronchial lesion in her right main bronchus which eventually turned out to be carcinoid tumour. She responded to resection and antibiotic therapy.


Cognitive Issues In Childhood Cancer Survivors And Related Parental Perceptions And Behaviors: An Integrative Review Of Literature, Brian DeCant, Joseph Tariman 2017 DePaul University

Cognitive Issues In Childhood Cancer Survivors And Related Parental Perceptions And Behaviors: An Integrative Review Of Literature, Brian Decant, Joseph Tariman

Grace Peterson Nursing Research Colloquium

Background: Survivorship of childhood cancer is often accompanied by neurocognitive late-effects (NCLE) related to the disease and/or it’s associated treatment regimes.

Objectives: The primary purpose of this integrative literature review was to examine NCLE in pediatric cancer survivors and identify parental perceptions and behaviors that correlated to cognitive dysfunction in their children.

Method: An integrative literature review was completed utilizing searches in PubMed, CINAHL Complete, and PsycINFO. Some search terms included “childhood cancer”, “survivor”, “cognition”, “cognitive disorder”, “neurocognitive”, “late-effects”, “child(ren)”, “parent(s)”, and “perception”.

Results: Analysis of ten predominant methods of neurocognitive evaluation yielded five major cognitive ...


Developing A Peer Cancer Support Group Evaluation, Glenda Kith 2017 The University of San Francisco

Developing A Peer Cancer Support Group Evaluation, Glenda Kith

Master's Projects and Capstones

Introduction: For many years, health care organizations have offered peer cancer support groups to cancer survivors, but peer cancer support group evaluation is not standardized. Without a clear and consistent evaluation, it may be difficult to understand the efficacy of and gain support for peer cancer support groups. In this paper, I discuss how an evaluation was created for a peer cancer support group called Cancer Awareness Resource and Education (CARE).

Methods: In-depth interviews with CARE participants were conducted and pre-survey and a post-survey were developed. The in-depth interviews included a convenience sample of eight individuals, two individuals from the ...


Multiple Myeloma Baseline Immunoglobulin G Level And Pneumococcal Vaccination Antibody Response, Michael A. Thompson, Martin K. Oaks, Maharaj Singh, Karen M. Michel, Michael P. Mullane, Husam S. Tarawneh, Angi Kraut, Kayla J. Hamm 2017 Aurora Research Institute / Aurora Cancer Care, Aurora Health Care

Multiple Myeloma Baseline Immunoglobulin G Level And Pneumococcal Vaccination Antibody Response, Michael A. Thompson, Martin K. Oaks, Maharaj Singh, Karen M. Michel, Michael P. Mullane, Husam S. Tarawneh, Angi Kraut, Kayla J. Hamm

Journal of Patient-Centered Research and Reviews

Infections are a major cause of morbidity and mortality in multiple myeloma (MM), a cancer of the immune system. Vaccination clinical efficacy endpoints have not been demonstrated, and there are limited data on surrogate markers of efficacy. This pilot study evaluated sequential immunologic markers after standard pneumococcal vaccination (PV) in patients with MM and non-MM controls. Vaccination was standard for PV (PCV13 or PPV23), with laboratory testing at baseline and at 2, 4, 12 and 24 weeks after vaccination. Immunoglobulin G (IgG) antibodies to pneumococcal antigens were detected by ELISA. Prevaccination total IgG levels and IgG subclass levels were also ...


Computational Drug Design: A Multitargeted Approach In Bladder Cancer, Travis C. Lantz, Joydeb Majumder, Gaurav Chopra 2017 Purdue University

Computational Drug Design: A Multitargeted Approach In Bladder Cancer, Travis C. Lantz, Joydeb Majumder, Gaurav Chopra

The Summer Undergraduate Research Fellowship (SURF) Symposium

Cancer is a complex, robust disease with multiple redundant disease pathways which lead to tumor development, growth, and eventually even death. Despite known redundancies, cancer therapeutics continue to be developed against a single protein target. Initial disease regression occurs followed by relapse in a drug resistant disease state. In response, combinational drug clinical trial targeting multiple pathways began, and have failed due to increased toxicity caused by adverse drug interactions. Development of a single drug that differentially targets multiple disease pathways will result in a more potent therapeutic while inducing minimal toxicity. This was done computationally through in-lab software packages ...


Metabolic Regulation Of Cellular Signaling, Rashid John Darbandi 2017 University of Tennessee Health Science Center

Metabolic Regulation Of Cellular Signaling, Rashid John Darbandi

Theses and Dissertations (ETD)

Using the biochemically tractable Xenopus oocyte model system, we have previously characterized a novel metabolic regulation of cell death. We found that glucose-6-phosphate (G6P) via the pentose phosphate pathway leads to increased nicotinamide adenine dinucleotide phosphate (NADPH) levels, a subsequent increase in cytosolic acetyl-coenzyme A and activation of Ca2+/calmodulin-dependent protein kinase II (CaMKII). We recently identified coenzyme A (CoA), derived from the breakdown of acetyl-CoA, as the key metabolic signal that mediates a novel mechanism of calmodulindependent activation of CaMKII. CoA binds directly to the calmodulin (CaM) binding domain (CaMBD) of CaMKII resulting in its activation and downstream inhibitory ...


Mechanisms Underlying Chemotherapy-Induced Vascular Proliferation In Ovarian Cancer, Zeynep Gülsüm Kahramanoğlu 2017 The University of Western Ontario

Mechanisms Underlying Chemotherapy-Induced Vascular Proliferation In Ovarian Cancer, Zeynep Gülsüm Kahramanoğlu

Electronic Thesis and Dissertation Repository

Ovarian cancer is a leading cause of gynecological cancer-related death in Canadian women. Ovarian cancer is managed through surgical cytoreduction and carboplatin-based chemotherapy. Unfortunately, most patients often relapse or have reduced responses to initial chemotherapy. The mechanisms behind carboplatin resistance are poorly understood. In pilot studies, our group has observed vascular proliferation in patient samples following carboplatin treatment. The effectiveness of modulating neovascularization in combination with carboplatin has also been demonstrated in two large Phase 3 trials. In this study, I explore the underlying mechanisms of chemotherapy-induced vascular proliferation and potentially, tumour cell survival. I hypothesize that carboplatin induces angiogenic ...


Cancer Prevention And Screening, James Liebmann 2017 University of Massachusetts Medical School

Cancer Prevention And Screening, James Liebmann

Cancer Concepts: A Guidebook for the Non-Oncologist

Current treatments of cancer are imperfect and entail risks. For many malignancies, the best “treatment” is to prevent the cancer from ever appearing in the first place. Cancer prevention refers to interventions that reduce the incidence of cancer. Such interventions can include reduction of exposure to known carcinogens (e.g., tobacco), treatment with drugs that lower cancer risk (chemoprevention), vaccination against infectious agents that cause cancer, surgery to remove organs at high risk of developing cancer in individuals with familial cancer syndromes, or the adoption of a “healthy lifestyle” that modifies cancer risk. Cancer screening shares some concepts with cancer ...


Praja Is Overexpressed In Glioblastoma And Contributes To Neural Precursor Development, Joshua Shin, Viveka Mishra, Eric Glasgow, Sobia Zaidi, Kazufumi Ohshiro, Lopa Mishra, Shuyun Rao, +several additional authors 2017 George Washington University

Praja Is Overexpressed In Glioblastoma And Contributes To Neural Precursor Development, Joshua Shin, Viveka Mishra, Eric Glasgow, Sobia Zaidi, Kazufumi Ohshiro, Lopa Mishra, Shuyun Rao, +Several Additional Authors

Medicine Faculty Publications

PRAJA, a RING-H2 E3 ligase, is abundantly expressed in brain tissues such as the cerebellum and frontal cortex, amongst others, and more specifically in neural progenitor cells as well as in multiple cancers that include glioblastomas. However, the specific role that Praja plays in neural development and gliomas remains unclear. In this investigation, we performed bioinformatic analyses to examine Praja1 and Praja2 expression across 29 cancer types, and observed raised levels of Praja1 and Praja2 in gliomas with an inverse relationship between Praja1 and apoptotic genes and Praja substrates such as Smad3. We analyzed the role of Praja in the ...


Managing Renal Cell Carcinoma Associated Paraneoplastic Syndrome With Nephron-Sparing Surgery In A Patient With Von Hippel-Lindau., John M DiBianco, Julie Y An, Sally Tanakchi, Zachary Stanik, Aidan McGowan, Mahir Maruf, Abhinav Sidana, Amit Lodha Jain, Akhil Muthigi, Arvin K George, Christopher Bayne, W Marston Linehan, Shawna L Boyle, Adam R Metwalli 2017 George Washington University

Managing Renal Cell Carcinoma Associated Paraneoplastic Syndrome With Nephron-Sparing Surgery In A Patient With Von Hippel-Lindau., John M Dibianco, Julie Y An, Sally Tanakchi, Zachary Stanik, Aidan Mcgowan, Mahir Maruf, Abhinav Sidana, Amit Lodha Jain, Akhil Muthigi, Arvin K George, Christopher Bayne, W Marston Linehan, Shawna L Boyle, Adam R Metwalli

Urology Faculty Publications

A patient with germline von Hippel-Lindau (VHL) gene alteration and history of multiple tumors present with classical paraneoplastic syndrome (PNS) associated with renal cell carcinoma (RCC). She underwent open nephron sparing surgery with resolution of symptoms. She remained without recurrence of RCC for the initial 2 years of her follow-up. To the best of our knowledge, this case represents the first in which PNS was specifically resolved using a partial nephrectomy in a patient with VHL. This case report provides initial evidence for the potential role of nephron sparing surgery in the management of paraneoplastic symptoms associated with hereditary RCC.


A State-Wide Initiative To Promote Genetic Testing In An Underserved Population, Meghan L. Underhill, Traci M. Blonquist, Karleen Habin, Debra Lundquist, Kristen Shannon, Kathryn Robinson, Mary-Lou Woodford, Jean Boucher 2017 Dana-Farber Cancer Institute

A State-Wide Initiative To Promote Genetic Testing In An Underserved Population, Meghan L. Underhill, Traci M. Blonquist, Karleen Habin, Debra Lundquist, Kristen Shannon, Kathryn Robinson, Mary-Lou Woodford, Jean Boucher

Open Access Articles

Genetic testing for cancer susceptibility has been widely studied and utilized clinically. Access to genetic services in research and practice is largely limited to well-insured, Caucasian individuals. In 2009, the Cancer Resource Foundation (CRF) implemented the Genetic Information for Treatment Surveillance and Support (GIFTSS) program to cover the out-of-pocket expenses associated with cancer genetic testing, targeting high-risk individuals with limited financial means and limited health insurance coverage. Here, we (i) describe the characteristics of participants in the Massachusetts (MA) GIFTSS program and (ii) evaluate mutations found in this diverse sample. A secondary retrospective data analysis was performed using de-identified demographic ...


Alternative Splicing Promotes Tumour Aggressiveness And Drug Resistance In African American Prostate Cancer., Bi-Dar Wang, Kristin Ceniccola, SuJin Hwang, Ramez Andrawis, Anelia Horvath, Jennifer A Freedman, Jacqueline Olender, Stefan Knapp, Travers Ching, Lana Garmire, Vyomesh Patel, Mariano A Garcia-Blanco, Steven R Patierno, Norman H Lee 2017 George Washington University

Alternative Splicing Promotes Tumour Aggressiveness And Drug Resistance In African American Prostate Cancer., Bi-Dar Wang, Kristin Ceniccola, Sujin Hwang, Ramez Andrawis, Anelia Horvath, Jennifer A Freedman, Jacqueline Olender, Stefan Knapp, Travers Ching, Lana Garmire, Vyomesh Patel, Mariano A Garcia-Blanco, Steven R Patierno, Norman H Lee

Pharmacology and Physiology Faculty Publications

linical challenges exist in reducing prostate cancer (PCa) disparities. The RNA splicing landscape of PCa across racial populations has not been fully explored as a potential molecular mechanism contributing to race-related tumour aggressiveness. Here, we identify novel genome-wide, race-specific RNA splicing events as critical drivers of PCa aggressiveness and therapeutic resistance in African American (AA) men. AA-enriched splice variants of PIK3CD, FGFR3, TSC2 and RASGRP2 contribute to greater oncogenic potential compared with corresponding European American (EA)-expressing variants. Ectopic overexpression of the newly cloned AA-enriched variant, PIK3CD-S, in EA PCa cell lines enhances AKT/mTOR signalling and increases proliferative and ...


Reducing The Rate Of Late Stage Breast Cancer Through Effective Health Communication: An Opinion Piece, Rachele Hendricks-Sturrup 2017 Nova Southeastern University

Reducing The Rate Of Late Stage Breast Cancer Through Effective Health Communication: An Opinion Piece, Rachele Hendricks-Sturrup

Internet Journal of Allied Health Sciences and Practice

Purpose: Health and illness are traditionally characterized and treated differently across various ethnic groups, which encourages American health systems serving these diverse populations to explore culturally competent and safe ways to effectively reduce illness within such populations. Certain ethnic groups of women in the United States (US) bear greater risk of late stage breast cancer because of various circumstances, which include but are not limited to a lack of insurance or underinsurance and discomfort with and/or resentment toward the US healthcare system. The dominant culture and the social aspects of the modern American health system often and most favorably ...


African-American Esophageal Squamous Cell Carcinoma Expression Profile Reveals Dysregulation Of Stress Response And Detox Networks., Hayriye Verda Erkizan, Kory Johnson, Svetlana Ghimbovschi, Deepa Karkera, Gregory Trachiotis, Houtan Adib, Eric P Hoffman, Robert G Wadleigh 2017 George Washington University

African-American Esophageal Squamous Cell Carcinoma Expression Profile Reveals Dysregulation Of Stress Response And Detox Networks., Hayriye Verda Erkizan, Kory Johnson, Svetlana Ghimbovschi, Deepa Karkera, Gregory Trachiotis, Houtan Adib, Eric P Hoffman, Robert G Wadleigh

Genomics and Precision Medicine Faculty Publications

BACKGROUND: Esophageal carcinoma is the third most common gastrointestinal malignancy worldwide and is largely unresponsive to therapy. African-Americans have an increased risk for esophageal squamous cell carcinoma (ESCC), the subtype that shows marked variation in geographic frequency. The molecular architecture of African-American ESCC is still poorly understood. It is unclear why African-American ESCC is more aggressive and the survival rate in these patients is worse than those of other ethnic groups.

METHODS: To begin to define genetic alterations that occur in African-American ESCC we conducted microarray expression profiling in pairs of esophageal squamous cell tumors and matched control tissues.

RESULTS ...


Micrornas Of The Mir-17~92 Cluster Regulate Multiple Aspects Of Pancreatic Tumor Development And Progression, Brian J. Quattrochi, Anushree Gulvady, David R. Driscoll, Makoto Sano, David S. Klimstra, Christopher E. Turner, Brian C. Lewis 2017 University of Massachusetts Medical School

Micrornas Of The Mir-17~92 Cluster Regulate Multiple Aspects Of Pancreatic Tumor Development And Progression, Brian J. Quattrochi, Anushree Gulvady, David R. Driscoll, Makoto Sano, David S. Klimstra, Christopher E. Turner, Brian C. Lewis

Open Access Articles

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy characterized by resistance to currently employed chemotherapeutic approaches. Members of the mir-17~92 cluster of microRNAs (miRNAs) are upregulated in PDAC, but the precise roles of these miRNAs in PDAC are unknown. Using genetically engineered mouse models, we show that loss of mir-17~92 reduces ERK pathway activation downstream of mutant KRAS and promotes the regression of KRASG12D-driven precursor pancreatic intraepithelial neoplasias (PanINs) and their replacement by normal exocrine tissue. In a PDAC model driven by concomitant KRASG12D expression and Trp53 heterozygosity, mir-17~92 deficiency extended the survival of mice that lacked ...


Balb/C Mice Immunized With A Combination Of Virus-Like Particles Incorporating Kaposi Sarcoma-Associated Herpesvirus (Kshv) Envelope Glycoproteins Gpk8.1, Gb, And Gh/Gl Induced Comparable Serum Neutralizing Antibody Activity To Uv-Inactivated Kshv, Anne K. Barasa, Peng Ye, Meredith Phelps, Ganapathiram T. Arivudainambi, Timelia Tison, Javier Gordon Ogembo 2017 Beckman Research Institute of City of Hope, CA

Balb/C Mice Immunized With A Combination Of Virus-Like Particles Incorporating Kaposi Sarcoma-Associated Herpesvirus (Kshv) Envelope Glycoproteins Gpk8.1, Gb, And Gh/Gl Induced Comparable Serum Neutralizing Antibody Activity To Uv-Inactivated Kshv, Anne K. Barasa, Peng Ye, Meredith Phelps, Ganapathiram T. Arivudainambi, Timelia Tison, Javier Gordon Ogembo

Open Access Articles

Infection with Kaposi sarcoma-associated herpesvirus (KSHV) is estimated to account for over 44,000 new cases of Kaposi sarcoma annually, with 84% occurring in Africa, where the virus is endemic. To date, there is no prophylactic vaccine against KSHV. KSHV gpK8.1, gB, and gH/gL glycoproteins, implicated in the virus entry into host cells, are attractive vaccine targets for eliciting potent neutralizing antibodies (nAbs) against virus infection. We incorporated gpK8.1, gB, or gH/gL on the surface of virus-like particles (VLPs) and characterized these VLPs for their composition, size, and functionality. To determine which viral glycoprotein(s) elicit ...


Combination Photodynamic Therapy And Chemotherapy For Temozolomide-Resistant Glioblastoma, Janel Kydd, Rahul Jadia, Prakash Rai 2017 University of Massachusetts Lowell

Combination Photodynamic Therapy And Chemotherapy For Temozolomide-Resistant Glioblastoma, Janel Kydd, Rahul Jadia, Prakash Rai

UMass Center for Clinical and Translational Science Research Retreat

Polymer based nanoparticles (NPs) are useful vehicles for drug therapy in treating glioblastoma because of their ideal characteristics such as small size, to cross the blood-brain barrier, and bind to overexpressed transferrin receptors via peptide conjugation and surface modification of NPs. The use of a photosensitizer drug such as verteporfin, or BPD, in combination with a repurposed drug, Cediranib (CED), prepared as a nanoparticle therapy will provide the medical field with new research on the possible ways to treat glioblastoma. BPD-CED-loaded NPs have the potential to induce cytotoxicity in glioblastoma cells by 1) remotely triggering BPD through photodynamic therapy by ...


Cancer Diagnosis Using Libs And Machine Learning Tools: Progress And Challenges, Noureddine Melikechi, Rosalba Gaudiuso, Ebo Ewusi-Annan 2017 University of Massachusetts Lowell

Cancer Diagnosis Using Libs And Machine Learning Tools: Progress And Challenges, Noureddine Melikechi, Rosalba Gaudiuso, Ebo Ewusi-Annan

UMass Center for Clinical and Translational Science Research Retreat

Despite numerous research and development efforts that provide important tools to fight cancer, this disease still poses great challenges to diagnosis and treatment, and it remains one of the leading causes of death worldwide. Early diagnosis is crucial to increase the survival rate and quality of life of cancer patients. Thus, developing non-invasive screening methods would represent a key step towards point-of-care large scale screening and prevention of asymptomatic tumors such as Epithelian Ovarian Cancer (EOC) and others. Our group has developed two experimental strategies to pursue early cancer diagnosis through Laser-Induced Breakdown Spectroscopy (LIBS), a versatile atomic spectroscopy technique ...


Black-White Disparities In Pain Management Among Nursing Home Residents With Cancer, Deborah Mack, Jacob N. Hunnicutt, William M. Jesdale, Christine M. Ulbricht, Kate L. Lapane 2017 University of Massachusetts Medical School

Black-White Disparities In Pain Management Among Nursing Home Residents With Cancer, Deborah Mack, Jacob N. Hunnicutt, William M. Jesdale, Christine M. Ulbricht, Kate L. Lapane

UMass Center for Clinical and Translational Science Research Retreat

Background: Racial disparities in pain management persist across healthcare settings and likely extend into nursing homes. No studies to-date have thoroughly evaluated racial disparities in cancer pain management in this setting.

Methods: Using a cross-sectional study design, we compared reported pain and pharmacological pain management between non-Hispanic White and Black newly admitted nursing home residents with cancer (n=113,765) using the Minimum Data Set version 3.0. Pain management strategies considered included: use of scheduled analgesics, pro re nata analgesics, and non-pharmacological methods. Presence of pain was based on self-report when residents were able to, or by staff. Logistic ...


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