Parasitic Diseases Commons^™

The Dynamics Of Naturally Acquired Immunity To Plasmodium Falciparum Infection, Mykola Pinkevych, Janka Petravic, Kiprotich Chelimo, James W. Kazura, Ann M. Moormann, Miles P. Davenport

Pediatric Publications and Presentations

Severe malaria occurs predominantly in young children and immunity to clinical disease is associated with cumulative exposure in holoendemic settings. The relative contribution of immunity against various stages of the parasite life cycle that results in controlling infection and limiting disease is not well understood. Here we analyse the dynamics of Plasmodium falciparum malaria infection after treatment in a cohort of 197 healthy study participants of different ages in order to model naturally acquired immunity. We find that both delayed time-to-infection and reductions in asymptomatic parasitaemias in older age groups can be explained by immunity that reduces the growth of ...

Broadly Reactive Antibodies Specific For Plasmodium Falciparum Msp-119 Are Associated With The Protection Of Naturally Exposed Children Against Infection, Arlene E. Dent, Ann M. Moormann, Christopher T. Yohn, Rhonda J. Kimmel, Peter Odada Sumba, John Vulule, Carole A. Long, David L. Narum, Brendan S. Crabb, James W. Kazura, Daniel J. Tisch

Quantitative Health Sciences Publications and Presentations

BACKGROUND: The 19 kDa C-terminal region of Plasmodium falciparum Merozoite Surface Protein-1 is a known target of naturally acquired humoral immunity and a malaria vaccine candidate. MSP- 119 has four predominant haplotypes resulting in amino acid changes labelled EKNG, QKNG, QTSR and ETSR. IgG antibodies directed against all four variants have been detected, but it is not known if these variant specific antibodies are associated with haplotype-specific protection from infection.

METHODS: Blood samples from 201 healthy Kenyan adults and children who participated in a 12-week treatment time-to-infection study were evaluated. Venous blood drawn at baseline (week 0) was examined for ...