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Nutritional and Metabolic Diseases Commons

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Sleep Duration And The Effects On Cholesterol Levels In College Students., Jared Collier 2020 University of Arkansas, Fayetteville

Sleep Duration And The Effects On Cholesterol Levels In College Students., Jared Collier

Biological Sciences Undergraduate Honors Theses

Cardiovascular disease is a rising issue in the United States causing large death rates along with large medical expenses. College students are potentially at risk of CVD due to a lack of knowledge of their health, including cholesterol level. Sleep is an essential biological function which helps with the body’s repair, recovery, conservation of energy and maintains cardiovascular regulation. The purpose of this study was to see if there is a correlation between sleep duration and cholesterol levels in college students. Twenty-seven student participants were recruited from the Exercise is Medicine cohort . In-person assessments were conducted at the HPER ...


An Investigation Of Treatments For The Prevention Of Metabolic Complications For Women Suffering From Polycystic Ovarian Syndrome: Diet, Exercise, Weight Reduction And Herbal Remedies, Brenda Martinez-Puente 2020 Dominican University of California

An Investigation Of Treatments For The Prevention Of Metabolic Complications For Women Suffering From Polycystic Ovarian Syndrome: Diet, Exercise, Weight Reduction And Herbal Remedies, Brenda Martinez-Puente

Nursing | Senior Theses

The purpose of this research study is to compare the views of traditional versus alternative treatments available to women with Polycystic Ovarian Syndrome (PCOS) suffering from metabolic complications. Alternative treatments include diet, exercise, herbal remedies, or any combination of the three. Pharmacological interventions for the conditions associated with PCOS such as metformin, used to control glucose levels, and clomiphene, used to treat infertility. Through the literature review, articles show herbs and plant products to have similar mechanisms of actions as the pharmacological interventions, but with less side effects. For example, cinnamon was shown to increase insulin sensitivity and pomegranate juice ...


The Role Of Nutrition In Promoting Gut Health And Treating Chronic Illness Through The Attenuation Of Inflammation, Allison Dalton 2020 HCA

The Role Of Nutrition In Promoting Gut Health And Treating Chronic Illness Through The Attenuation Of Inflammation, Allison Dalton

HCA Healthcare Journal of Medicine

Over the millennia, the human body and microorganisms such as bacteria, viruses, archaea, protozoa and parasites have coevolved together forming an intimate relationship. These microorganisms are found on the skin, in the mouth, genitourinary tract and most abundantly in the large intestine of the digestive tract. States of microbial dysbiosis contribute to chronic inflammation, which can lead to the pathogenesis and progression of numerous diseases. Micro- and macro-nutrients as well as dietary patterns like the Mediterranean diet can help improve health outcomes.


Developmental Regression And Mitochondrial Function In Children With Autism, Kanwaljit Singh, Indrapal N. Singh, Eileen Diggins, Susan Connors, Mohammad A. Karim, David Lee, Andrew W. Zimmerman, Richard E. Frye 2020 University of Massachusetts Medical School

Developmental Regression And Mitochondrial Function In Children With Autism, Kanwaljit Singh, Indrapal N. Singh, Eileen Diggins, Susan Connors, Mohammad A. Karim, David Lee, Andrew W. Zimmerman, Richard E. Frye

Open Access Articles

BACKGROUND: Developmental regression (DR) occurs in about one-third of children with Autism Spectrum Disorder (ASD) yet it is poorly understood. Current evidence suggests that mitochondrial function in not normal in many children with ASD. However, the relationship between mitochondrial function and DR has not been well-studied in ASD.

METHODS: This cross-sectional study of 32 children, 2 to 8 years old with ASD, with (n = 11) and without (n = 12) DR, and non-ASD controls (n = 9) compared mitochondrial respiration and mtDNA damage and copy number between groups and their relation to standardized measures of ASD severity.

RESULTS: Individuals with ASD demonstrated ...


Data Analysis Of A National Health And Nutrition Examination Survey (Nhanes) To Identify The Relationship Between Obesity And Cancer, Reyhaneh A. Yazdi, Ramona Stone 2020 West Chester University of Pennsylvania

Data Analysis Of A National Health And Nutrition Examination Survey (Nhanes) To Identify The Relationship Between Obesity And Cancer, Reyhaneh A. Yazdi, Ramona Stone

Health Student Work

Introduction: Obesity and cancer independently are two important causes of death in the USA. A growing number of studies shows that these two chronic illnesses are related.

Objective: To examine the relationship of cancer and obesity using BMI and Waist Circumference (WC) as indicators using the National Health and Nutrition Examination Survey (NHANES) dataset.

Method: NHANES (2013-2014) dataset was used to obtain information on BMI, Waist Circumference (WC), and cancer (presence or absence) among the participants. The prevalence of obesity and cancer was tested with Pearson λ^2 test and the relationship of these two with education (5 levels) was ...


Continuous Glucose Monitors To Decrease Hypoglycemia, Sara B. Woodcock 2020 University of Texas at Tyler

Continuous Glucose Monitors To Decrease Hypoglycemia, Sara B. Woodcock

MSN Capstone Projects

Diabetes is a disease that affects millions of people from children to older adults. There is no cure, although it can be managed to prevent complications. Education of student nurses is where they are born and raised to become nurses who save and change lives. Teaching student nurses in depth about diabetes as a disease and the treatments that best fit their specific needs is where educating patients begins. Learning about a secondary option for blood glucose checks can make all the difference for several patients. Multiple finger sticks daily has been the leading way to check blood sugar for ...


How Immune T-Cell Augmentation Can Help Prevent Covid-19: A Possible Nutritional Solution Using Ketogenic Lifestyle, Ravi k. Kamepalli MD,FIDSA,CWSP 2020 Regional Infectious diseases and infusion ctr,Inc

How Immune T-Cell Augmentation Can Help Prevent Covid-19: A Possible Nutritional Solution Using Ketogenic Lifestyle, Ravi K. Kamepalli Md,Fidsa,Cwsp

The University of Louisville Journal of Respiratory Infections

No abstract provided.


Community Cooking Course To Combat Nutritional Knowledge Deficit, Heather R. Bohman 2020 The University of Texas at Tyler

Community Cooking Course To Combat Nutritional Knowledge Deficit, Heather R. Bohman

MSN Capstone Projects

More than two-thirds of American adults and almost one-third of American children are overweight or obese. Not only are the statistics alarming, the cost of obesity is staggering. Obesity robs an individual of their quality of life and costs the U.S. healthcare system an estimated $147 billion a year in obesity-related illness (Finkelstein, Trogdon, Cohen, & Dietz, 2009). The need to find solutions to improve the health of Americans is clear and communities are called to respond. The Centers for Disease Control and Prevention (CDC, 2018) recommends partnership with local agencies to promote obesity prevention initiatives and create a healthier food environment for all. Evidence suggests that interventions, such as cooking classes, can be made to improve the overall health of a community and reduce the obesity epidemic (Ickes, Mcmullen, Haider, & Sharma, 2014). The PICOT question asks, in low-income families (P), how does participating in a community cooking course (I) compared to not participating in a cooking course (C) affect nutritional knowledge (O) after completion of the cooking course (T)? In partnership with Hill Country Family Services (HCFS) of Kendall County, Texas, this capstone project set out to provide family centered cooking classes featuring accessible, low cost, and nutritious foods with the aim to improve nutritional knowledge and boost self-efficacy to a vulnerable population. Cooking classes were designed around the United States Department of Agriculture’s (USDA) Choose My Plate guidelines and the national Share Our Strength’s Cooking Matters for Families campaign (USDA, n.d.; Share Our Strength, 2019). Classes geared toward children accompanied by an adult were planned to feature fun activities and hands on cooking experiences. Unfortunately, the project was frozen mid-implementation due to a global pandemic. This paper will discuss the project thus far and outline ...


Deconstructing Circadian Disruption: Assessing The Contribution Of Reduced Peripheral Oscillator Amplitude On Obesity And Glucose Intolerance In Mice, Vincent van der Vinne, Blanca Martin Burgos, Mary E. Harrington, David R. Weaver 2020 University of Massachusetts Medical School

Deconstructing Circadian Disruption: Assessing The Contribution Of Reduced Peripheral Oscillator Amplitude On Obesity And Glucose Intolerance In Mice, Vincent Van Der Vinne, Blanca Martin Burgos, Mary E. Harrington, David R. Weaver

Neurobiology Publications

Disturbing the circadian regulation of physiology by disruption of the rhythmic environment is associated with adverse health outcomes but the underlying mechanisms are unknown. Here, the response of central and peripheral circadian clocks to an advance or delay of the light-dark cycle was determined in mice. This identified transient damping of peripheral clocks as a consequence of an advanced light-dark cycle. Similar depression of peripheral rhythm amplitude was observed in mice exposed to repeated phase shifts. To assess the metabolic consequences of such peripheral amplitude depression in isolation, temporally chimeric mice lacking a functional central clock (Vgat-Cre(+) Bmal1(fl/fl ...


Society Of Behavioral Medicine Call To Action: Include Obesity/Overweight Management Education In Health Professional Curricula And Provide Coverage For Behavior-Based Treatments Of Obesity/Overweight Most Commonly Provided By Psychologists, Dieticians, Counselors, And Other Health Care Professionals And Include Such Providers On All Multidisciplinary Teams Treating Patients Who Have Overweight Or Obesity, Judith K. Ockene, Karen M. Ashe, Kenneth S. Peterson, Marian Fitzgibbon, Joanna Buscemi, Akilah Dulin 2020 University of Massachusetts Medical School

Society Of Behavioral Medicine Call To Action: Include Obesity/Overweight Management Education In Health Professional Curricula And Provide Coverage For Behavior-Based Treatments Of Obesity/Overweight Most Commonly Provided By Psychologists, Dieticians, Counselors, And Other Health Care Professionals And Include Such Providers On All Multidisciplinary Teams Treating Patients Who Have Overweight Or Obesity, Judith K. Ockene, Karen M. Ashe, Kenneth S. Peterson, Marian Fitzgibbon, Joanna Buscemi, Akilah Dulin

UMass Worcester PRC Publications

Obesity is a serious chronic disease whose prevalence has grown to epidemic proportions over the past five decades and is a major contributor to the global burden of most common cancers, heart disease, Type 2 diabetes, liver disease, and sleep apnea. Primary care clinicians, including physicians, nurse practitioners, and physician assistants, are often the first health care professionals to identify obesity or overweight during routine long-term care and have the opportunity to intervene to prevent and treat disease. However, they often lack the training and skills needed to deliver scientifically validated, behavior-based treatments. These gaps must be addressed in order ...


A High Glucose Concentration Is Well Tolerated By Colorectal Adenocarcinoma And Melanoma Cells But Toxic To Normal Human Gingival Fibroblast: Results Of An In Vitro Investigation, Muhammad Alif Mazlan, Afzan Mat Yusof, Muhammad Lokman Md Isa 2020 Department Basic Medical Sciences for Nursing, International Islamic University Malaysia, Kuantan 25200, Malaysia

A High Glucose Concentration Is Well Tolerated By Colorectal Adenocarcinoma And Melanoma Cells But Toxic To Normal Human Gingival Fibroblast: Results Of An In Vitro Investigation, Muhammad Alif Mazlan, Afzan Mat Yusof, Muhammad Lokman Md Isa

Makara Journal of Health Research

Background: Glucose is associated with weight gain, which increases the risk of cancer. There is insufficient information on the effects of high glucose concentrations on cell lines. This study evaluated the viability patterns of human cancer and normal cell lines treated with glucose.

Methods: Human gingival fibroblast (hGF), colorectal adenocarcinoma (HT29), and skin malignant melanoma (A375) cell lines were cultured and treated with additional glucose in three respective concentrations: 1 mg/ml, 5 mg/ml, and 10 mg/ml. Then, cell viability was measured using an MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide)-assay. The data were analyzed using ...


Are Dietary Fish Oil Supplements Appropriate For Dyslipidemia Management? A Review Of The Evidence, Samuel C. R. Sherratt, Michael Lero, R. Preston Mason 2020 Elucida Research LLC

Are Dietary Fish Oil Supplements Appropriate For Dyslipidemia Management? A Review Of The Evidence, Samuel C. R. Sherratt, Michael Lero, R. Preston Mason

Open Access Articles

PURPOSE OF REVIEW: The purpose of this review is to assess whether dietary fish oil supplements can be appropriate for patients with elevated triglycerides and cardiovascular risk based on a comprehensive analysis of their composition, and level of regulatory oversight.

RECENT FINDINGS: Approximately 19 million people in the United States take fish oil supplements, many for the purpose of treating or preventing heart disease. Unlike prescription products, fish oil supplements are classified as food by the Food and Drug Administration (FDA) and are not required to undergo manufacturing oversight or clinical testing. Analysis of widely used dietary fish oil supplements ...


Mechanisms Of Insulin Resistance Related To White, Beige, And Brown Adipocytes, Michael P. Czech 2020 University of Massachusetts Medical School

Mechanisms Of Insulin Resistance Related To White, Beige, And Brown Adipocytes, Michael P. Czech

Open Access Articles

BACKGROUND: The diminished glucose lowering effect of insulin in obesity, called "insulin resistance," is associated with glucose intolerance, type 2 diabetes, and other serious maladies. Many publications on this topic have suggested numerous hypotheses on the molecular and cellular disruptions that contribute to the syndrome. However, significant uncertainty remains on the mechanisms of its initiation and long-term maintenance.

SCOPE OF REVIEW: To simplify insulin resistance analysis, this review focuses on the unifying concept that adipose tissue is a central regulator of systemic glucose homeostasis by controlling liver and skeletal muscle metabolism. Key aspects of adipose function related to insulin resistance ...


A Case Series Of Hyponatremia And Management In Hospitalized Patients, Jake N. Cho MD, Rebecca Ong MD, Izuchukwu Nwakoby MD 2020 HCA Healthcare

A Case Series Of Hyponatremia And Management In Hospitalized Patients, Jake N. Cho Md, Rebecca Ong Md, Izuchukwu Nwakoby Md

Nephrology

No abstract provided.


Cultural Influences On Dietary Self-Management Of Type 2 Diabetes In East Asian Americans: A Mixed-Methods Systematic Review, Tony Li-Geng, Jessica Kilham, Katherine M. McLeod 2020 Quinnipiac University

Cultural Influences On Dietary Self-Management Of Type 2 Diabetes In East Asian Americans: A Mixed-Methods Systematic Review, Tony Li-Geng, Jessica Kilham, Katherine M. Mcleod

Open Access Articles

Purpose: Many East Asian Americans (EAAs) (populations originating from China, Korea, Japan, and Taiwan) with type 2 diabetes mellitus (T2DM) experience unique challenges in managing their disease, including language barriers and traditional cultural beliefs, particularly among first-generation immigrants. The purpose of this mixed-methods systematic review was to examine cultural perspectives of EAAs that influence dietary self-management of T2DM and identify education interventions and their approaches to enhance EAAs' dietary self-management of diabetes.

Methods: A mixed-methods systematic review was conducted to examine EAAs' perspectives from qualitative studies and to identify education interventions and their approaches from quantitative studies. A literature search ...


Diabetes Mellitus Type 2 Is Associated With Increased Tumor Expression Of Programmed Death-Ligand 1 (Pd-L1) In Surgically Resected Non-Small Cell Lung Cancer - A Matched Case-Control Study, Christopher A. Febres-Aldana, Robert Poppiti, John M. Varlotto, Rick Voland, Michael Zaleski, Setareh Sharzehi, Negar Rassaei 2020 Mount Sinai Medical Center

Diabetes Mellitus Type 2 Is Associated With Increased Tumor Expression Of Programmed Death-Ligand 1 (Pd-L1) In Surgically Resected Non-Small Cell Lung Cancer - A Matched Case-Control Study, Christopher A. Febres-Aldana, Robert Poppiti, John M. Varlotto, Rick Voland, Michael Zaleski, Setareh Sharzehi, Negar Rassaei

Open Access Articles

OBJECTIVES: Programmed death-ligand 1 (PD-L1) expression is a biomarker for cancer immunotherapy. Diabetes mellitus type-2 is a comorbid disease associated with adverse outcomes in Non-Small Cell Lung Cancer (NSCLC). We aimed to investigate the differences in PD-L1 expression in diabetics.

METHODS: A matched case-control cohort of surgically-resected NSCLC was assembled from an early multicenter study (PMID: 19152440). PD-L1 immunohistochemistry (Clone 22C3) was graded by a tumor positive score (TPS) system (TPS0: no staining; TPS1: < 1%; TPS2: 1-49%; TPS3: > /=50%). Variables showing significance at univariate survival analysis were fit in a Cox regression survival model.

RESULTS: Diabetics (n=40) and nondiabetics (n=39) showed no ...


Hypercholesterolemia Accelerates The Aging Phenotypes Of Hematopoietic Stem Cells By A Tet1-Dependent Pathway, Guodong Tie, Jinglian Yan, Lyne Khair, Amanda A. Tutto, Louis M. Messina 2020 University of Massachusetts Medical School

Hypercholesterolemia Accelerates The Aging Phenotypes Of Hematopoietic Stem Cells By A Tet1-Dependent Pathway, Guodong Tie, Jinglian Yan, Lyne Khair, Amanda A. Tutto, Louis M. Messina

Open Access Articles

Hypercholesterolemia accelerates the phenotypes of aging in hematopoietic stem cells (HSCs). As yet, little is known about the underlying mechanism. We found that hypercholesterolemia downregulates Ten eleven translocation 1 (Tet1) in HSCs. The total HSC population was increased, while the long-term (LT) population, side population and reconstitution capacity of HSCs were significantly decreased in Tet1(-/-) mice. Expression of the Tet1 catalytic domain in HSCs effectively restored the LT population and reconstitution capacity of HSCs isolated from Tet1(-/-) mice. While Tet1 deficiency upregulated the expression of p19 and p21 in HSCs by decreasing the H3K27me3 modification, the restoration of Tet1 activity ...


Proteomic And Transcriptional Profiles Of Human Stem Cell-Derived Beta Cells Following Enteroviral Challenge, Julius O. Nyalwidhe, Agata Jurczyk, Basanthi Satish, Sambra D. Redick, Natasha Qaisar, Melanie I. Trombly, Pranitha Vangala, Riccardo Racicot, Rita Bortell, David M. Harlan, Dale L. Greiner, Michael A. Brehm, Jerry L. Nadler, Jennifer P. Wang 2020 Eastern Virginia Medical School

Proteomic And Transcriptional Profiles Of Human Stem Cell-Derived Beta Cells Following Enteroviral Challenge, Julius O. Nyalwidhe, Agata Jurczyk, Basanthi Satish, Sambra D. Redick, Natasha Qaisar, Melanie I. Trombly, Pranitha Vangala, Riccardo Racicot, Rita Bortell, David M. Harlan, Dale L. Greiner, Michael A. Brehm, Jerry L. Nadler, Jennifer P. Wang

Open Access Articles

Enteroviral infections are implicated in islet autoimmunity and type 1 diabetes (T1D) pathogenesis. Significant beta-cell stress and damage occur with viral infection, leading to cells that are dysfunctional and vulnerable to destruction. Human stem cell-derived beta (SC-beta) cells are insulin-producing cell clusters that closely resemble native beta cells. To better understand the events precipitated by enteroviral infection of beta cells, we investigated transcriptional and proteomic changes in SC-beta cells challenged with coxsackie B virus (CVB). We confirmed infection by demonstrating that viral protein colocalized with insulin-positive SC-beta cells by immunostaining. Transcriptome analysis showed a decrease in insulin gene expression following ...


The Interplay Of The Oral-Gut Microbiome With Chronic Inflammation In Rheumatoid Arthritis And Crohn's Disease, Anuradha Rampersaud 2020 Nova Southeastern University

The Interplay Of The Oral-Gut Microbiome With Chronic Inflammation In Rheumatoid Arthritis And Crohn's Disease, Anuradha Rampersaud

Mako: NSU Undergraduate Student Journal

Abstract

Rheumatoid Arthritis (RA) and Crohn’s Disease (CD) are both chronic inflammatory diseases that share developmental and treatment similarities. RA’s symptoms include swelling, stiffness, and pain in synovial joints, corresponding with bone and cartilage destruction. CD’s symptoms include abdominal pain, bowel obstruction, bloating, diarrhea, and fever. The purpose of this literature review was to investigate the links between these two diseases and propose future treatment and prevention targets. Current treatment for RA and CD aims to suppress inflammation by targeting its mediators. However, this review noted that there should be greater focus on resolving inflammation. Both diseases ...


Hyperammonemic Encephalopathy With Triphasic Waves: A Case, Brian Birdsong MD, Brielle Marks MD, Rishim Jayswal MD, Adeel Rahman 2020 HCA Healthcare

Hyperammonemic Encephalopathy With Triphasic Waves: A Case, Brian Birdsong Md, Brielle Marks Md, Rishim Jayswal Md, Adeel Rahman

Psychiatry

No abstract provided.


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