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Nutritional and Metabolic Diseases Commons

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A Novel Approach To The Safe And Effective Mobilization Of A Super-Obese Patient: A Case Report, Jessica Anaf, Amy Wigmore, Kathy Stiller 2017 Royal Adelaide Hospital

A Novel Approach To The Safe And Effective Mobilization Of A Super-Obese Patient: A Case Report, Jessica Anaf, Amy Wigmore, Kathy Stiller

Internet Journal of Allied Health Sciences and Practice

Purpose: The incidence of obesity is rising worldwide, as is the presentation of these patients to the acute hospital setting. As a result of their complex nature, including medical co-morbidities, psychosocial issues, and healthcare resource limitations, management of these patients requires a coordinated and intensive multi-disciplinary approach. Although there are considerable data reporting the surgical management of obese patients, there is very limited literature regarding non-surgical interventions, including approaches to safe and effective mobilization. Methods: A case report is presented of a 55-year-old super-obese male transferred to a major tertiary referral healthcare centre for management of his overall medical condition ...


Diet, Kidney Stones And Kidney Failure, lynda frassetto 2017 UCSF

Diet, Kidney Stones And Kidney Failure, Lynda Frassetto

Journal of Evolution and Health

No abstract provided.


Dietary Refinement And The Upper Gut Microbiota: The Starting Point For Obesity And Non-Communicable Diseases?, Ian Spreadbury 2017 Ancestral Health Society

Dietary Refinement And The Upper Gut Microbiota: The Starting Point For Obesity And Non-Communicable Diseases?, Ian Spreadbury

Journal of Evolution and Health

No abstract provided.


Assessment Of Diet In Patients With Inflammatory Bowel Disease: A Collaboration Of Behavioral And Basic Scientists, Barbara C. Olendzki, Aparna Kohli, Effie Olendzki, YuShuan (Cindy) Lai, Ana Maldonado-Contreras 2017 University of Massachusetts Medical School

Assessment Of Diet In Patients With Inflammatory Bowel Disease: A Collaboration Of Behavioral And Basic Scientists, Barbara C. Olendzki, Aparna Kohli, Effie Olendzki, Yushuan (Cindy) Lai, Ana Maldonado-Contreras

Community Engagement and Research Symposia

Introduction: Clinical research to develop treatment for inflammatory bowel disease (IBD) is focusing on a nutritional regimen restricting certain carbohydrates while incorporating the use of an optimal diet that includes pre- and probiotic foods. Current assessments are not able to measure elements of this nutritional regimen, thus we developed a food frequency questionnaire (FFQ). This FFQ will be utilized in a prospective study of IBD patients following an anti-inflammatory diet (IBD-AID) developed by us and used clinically at UMASS. We will track the bacterial communities inhabiting the microbiome of patients to determine diet-dependent changes, and their relation with patient wellbeing ...


Sustained Use Of Patient Portal Features And Improvements In Diabetes Physiological Measures, Stephanie L. Shimada, Jeroan J. Allison, Amy K. Rosen, Hua Feng, Thomas K. Houston 2017 University of Massachusetts Medical School

Sustained Use Of Patient Portal Features And Improvements In Diabetes Physiological Measures, Stephanie L. Shimada, Jeroan J. Allison, Amy K. Rosen, Hua Feng, Thomas K. Houston

Jeroan J. Allison

BACKGROUND: Personal health records (PHRs) have the potential to improve patient self-management for chronic conditions such as diabetes. However, evidence is mixed as to whether there is an association between PHR use and improved health outcomes.

OBJECTIVE: The aim of this study was to evaluate the association between sustained use of specific patient portal features (Web-based prescription refill and secure messaging-SM) and physiological measures important for the management of type 2 diabetes.

METHODS: Using a retrospective cohort design, including Veterans with diabetes registered for the My Health e Vet patient portal who had not yet used the Web-based refill or ...


Data From: Predictors Of Lack Of Partial Clinical Remission In New-Onset Pediatric Type 1 Diabetes, Katherine R. Marino, Rachel L. Lundberg, Aastha Jasrotia, Louise S. Maranda, Michael J. Thompson, Bruce A. Barton, Laura C. Alonso, Benjamin U. Nwosu 2017 University of Massachusetts Medical School

Data From: Predictors Of Lack Of Partial Clinical Remission In New-Onset Pediatric Type 1 Diabetes, Katherine R. Marino, Rachel L. Lundberg, Aastha Jasrotia, Louise S. Maranda, Michael J. Thompson, Bruce A. Barton, Laura C. Alonso, Benjamin U. Nwosu

Benjamin U. Nwosu

This dataset is the primary data source for a manuscript submitted for publication.


Data From: Predictors Of Lack Of Partial Clinical Remission In New-Onset Pediatric Type 1 Diabetes, Katherine R. Marino, Rachel L. Lundberg, Aastha Jasrotia, Louise S. Maranda, Michael J. Thompson, Bruce A. Barton, Laura C. Alonso, Benjamin U. Nwosu 2017 University of Massachusetts Medical School

Data From: Predictors Of Lack Of Partial Clinical Remission In New-Onset Pediatric Type 1 Diabetes, Katherine R. Marino, Rachel L. Lundberg, Aastha Jasrotia, Louise S. Maranda, Michael J. Thompson, Bruce A. Barton, Laura C. Alonso, Benjamin U. Nwosu

Pediatric Research Data

This dataset is the primary data source for a manuscript submitted for publication.


Ux007 For The Treatment Of Long Chain-Fatty Acid Oxidation Disorders: Safety And Efficacy In Children And Adults Following 24weeks Of Treatment., J Vockley, B Burton, G T Berry, N Longo, J Phillips, Pranoot Tanpaiboon, +several additional authors 2017 George Washington University

Ux007 For The Treatment Of Long Chain-Fatty Acid Oxidation Disorders: Safety And Efficacy In Children And Adults Following 24weeks Of Treatment., J Vockley, B Burton, G T Berry, N Longo, J Phillips, Pranoot Tanpaiboon, +Several Additional Authors

Pediatrics Faculty Publications

BACKGROUND: Long-chain fatty acid oxidation disorders (LC-FAOD) lead to accumulation of high concentrations of potentially toxic fatty acid intermediates. Newborn screening and early intervention have reduced mortality, but most patients continue to experience frequent hospitalizations and significant morbidity despite treatment. The deficient energy state can cause serious liver, muscle, and heart disease, and may be associated with an increased risk of sudden death. Triheptanoin is a medium odd-chain fatty acid. Anaplerotic metabolites of triheptanoin have the potential to replace deficient tricarboxylic acid (TCA) cycle intermediates, resulting in net glucose production as a novel energy source for the treatment of LC-FAOD ...


Piloting An Integrated, Interprofessional Programme For People Living With Type Ii Diabetes: Outcomes And Experiences, Daniel O'Brien, Susan M. McNaughton, Brenda Flood, Jane Morgan, Alexandra Bowmar 2016 Auckland University of Technology

Piloting An Integrated, Interprofessional Programme For People Living With Type Ii Diabetes: Outcomes And Experiences, Daniel O'Brien, Susan M. Mcnaughton, Brenda Flood, Jane Morgan, Alexandra Bowmar

Australian Journal of Clinical Education

This paper reports quantitative and descriptive qualitative findings from a mixed-methods study exploring and evaluating the outcomes and experiences of clients, staff and students piloting an integrated interprofessional programme for community members with type II diabetes. The one-day per week, eight-week programme included interprofessional appointments, group education sessions and case conferences led by students from exercise and nutrition, health promotion, nursing, occupational therapy, oral health, physiotherapy, podiatry and counselling psychology. Participants shared their experiences in individual interviews or focus groups. Client outcomes were evaluated using basic clinical indicators and the Canadian Occupational Performance Measure (COPM) that assesses client goal satisfaction ...


Nk-Cd11c+ Cell Crosstalk In Diabetes Enhances Il-6-Mediated Inflammation During Mycobacterium Tuberculosis Infection, Satyanarayana Swamy Cheekatla, Deepak Tripathi, Sambasivan Venkatasubramanian, Pavan Kumar Nathella, Padmaja Paidipally, Munenori Ishibashi, Elwyn Welch, Amy R. Tvinnereim, Mitsuo Ikebe, Vijaya Lakshmi Valluri, Subash Babu, Hardy Kornfeld, Ramakrishna Vankayalapati 2016 University of Texas Health Science Center at Tyler

Nk-Cd11c+ Cell Crosstalk In Diabetes Enhances Il-6-Mediated Inflammation During Mycobacterium Tuberculosis Infection, Satyanarayana Swamy Cheekatla, Deepak Tripathi, Sambasivan Venkatasubramanian, Pavan Kumar Nathella, Padmaja Paidipally, Munenori Ishibashi, Elwyn Welch, Amy R. Tvinnereim, Mitsuo Ikebe, Vijaya Lakshmi Valluri, Subash Babu, Hardy Kornfeld, Ramakrishna Vankayalapati

Open Access Articles

In this study, we developed a mouse model of type 2 diabetes mellitus (T2DM) using streptozotocin and nicotinamide and identified factors that increase susceptibility of T2DM mice to infection by Mycobacterium tuberculosis (Mtb). All Mtb-infected T2DM mice and 40% of uninfected T2DM mice died within 10 months, whereas all control mice survived. In Mtb-infected mice, T2DM increased the bacterial burden and pro- and anti-inflammatory cytokine and chemokine production in the lungs relative to those in uninfected T2DM mice and infected control mice. Levels of IL-6 also increased. Anti-IL-6 monoclonal antibody treatment of Mtb-infected acute- and chronic-T2DM mice increased survival (to ...


Process Evaluation Of A Patient-Centred, Patientdirected, Group-Based Education Program For The Management Of Type 2 Diabetes Mellitus, Kate Odgers-Jewell, Elisabeth Isenring, Rae Thomas, Dianne P Reidlinger 2016 Bond University

Process Evaluation Of A Patient-Centred, Patientdirected, Group-Based Education Program For The Management Of Type 2 Diabetes Mellitus, Kate Odgers-Jewell, Elisabeth Isenring, Rae Thomas, Dianne P Reidlinger

Faculty of Health Sciences & Medicine Publications

Aim:

The present study developed and evaluated a patient-centred, patient-directed, group-based education program for the management of type 2 diabetes mellitus.

Methods:

Two frameworks, the Medical Research Council (MRC) framework for developing and evaluating complex interventions and the RE-AIM framework were followed. Data to develop the intervention were sourced from scoping of the literature and formative evaluation. Program evaluation comprised analysis of primary recruitment of participants through general practitioners, baseline and end-point measures of anthropometry, four validated questionnaires, contemporaneous facilitator notes and telephone interviews with participants.

Results:

A total of 16 participants enrolled in the intervention. Post-intervention results were obtained ...


Effects Of S1p Mutation On Er Stress And Cholesterol Synthesis Markers In Human Epithelial Cells, Connie Gan, George G. Schweitzer, Rita T. Brookheart, Robert C. Bucelli, Brian N. Finck 2016 Washington University in St. Louis

Effects Of S1p Mutation On Er Stress And Cholesterol Synthesis Markers In Human Epithelial Cells, Connie Gan, George G. Schweitzer, Rita T. Brookheart, Robert C. Bucelli, Brian N. Finck

Undergraduate Research Symposium Posters

Site-1 Protease (S1P) is a Golgi-resident enzyme required for activation and subsequent nuclear localization of several major transcription factors. A 24-year-old female patient with a de novo single point mutation in S1P presented with a complex phenotype of gut hypomotility, abnormal optic nerves, and polycystic ovarian syndrome. Furthermore, this patient suffers from phenotypes related to skeletal muscle dysfunction, resulting in decreased ability to perform physical exercise due to unusual post-exercise pain, fatigue, nausea, and vomiting. This phenomenon has been described in the literature to manifest from myoedema and the breakdown of muscle that releases intracellular proteins into the blood, or ...


Independent Effects Of Diet And Exercise Training On Fat Oxidation In Non-Alcoholic Fatty Liver Disease., Ilaria Croci, Nuala M Byrne, Veronique S Chachay, Andrew P Hills, Andrew D Clouston, Trisha M O'Moore-Sullivan, Johannes B Prins, Graeme A Macdonald, Ingrid J Hickman 2016 University of Queensland

Independent Effects Of Diet And Exercise Training On Fat Oxidation In Non-Alcoholic Fatty Liver Disease., Ilaria Croci, Nuala M Byrne, Veronique S Chachay, Andrew P Hills, Andrew D Clouston, Trisha M O'Moore-Sullivan, Johannes B Prins, Graeme A Macdonald, Ingrid J Hickman

Faculty of Health Sciences & Medicine Publications

AIM:

To investigate the independent effects of 6-mo of dietary energy restriction or exercise training on whole-body and hepatic fat oxidation of patients with non-alcoholic fatty liver disease (NAFLD).

METHODS:

Participants were randomised into either circuit exercise training (EX; n = 13; 3 h/wk without changes in dietary habits), or dietary energy restriction (ER) without changes in structured physical activity (ER; n = 8). Respiratory quotient (RQ) and whole-body fat oxidation rates (Fatox) were determined by indirect calorimetry under basal, insulin-stimulated and exercise conditions. Severity of disease and steatosis was determined by liver histology; hepatic Fatox was estimated from plasma β-hydroxybutyrate ...


An Evaluation Of African American Fathers’ Perceptions And Influences On Child Food Choices And Physical Activity Behaviors, Valerie Annette Richardson 2016 University of Southern Mississippi

An Evaluation Of African American Fathers’ Perceptions And Influences On Child Food Choices And Physical Activity Behaviors, Valerie Annette Richardson

Dissertations

Child obesity is affecting children’s health nationwide. Rates are highest among African Americans (AA) in the South. Research has explored parents’ influence on child eating and activity, but most has reported on mothers’ influences. The purpose of this research was to investigate perceptions about AA fathers’ influences on their children’s eating and physical activity. Using a structured focus group questionnaire based on the parent layer constructs of Birch and Ventura’s Ecological Model for Child Overweight (2009), four focus groups were conducted with 28 AA fathers with children 6- to 11-years-old in a rural and an urban church ...


Sustained Use Of Patient Portal Features And Improvements In Diabetes Physiological Measures, Stephanie L. Shimada, Jeroan J. Allison, Amy K. Rosen, Hua Feng, Thomas K. Houston 2016 University of Massachusetts Medical School

Sustained Use Of Patient Portal Features And Improvements In Diabetes Physiological Measures, Stephanie L. Shimada, Jeroan J. Allison, Amy K. Rosen, Hua Feng, Thomas K. Houston

University of Massachusetts Medical School Faculty Publications

BACKGROUND: Personal health records (PHRs) have the potential to improve patient self-management for chronic conditions such as diabetes. However, evidence is mixed as to whether there is an association between PHR use and improved health outcomes.

OBJECTIVE: The aim of this study was to evaluate the association between sustained use of specific patient portal features (Web-based prescription refill and secure messaging-SM) and physiological measures important for the management of type 2 diabetes.

METHODS: Using a retrospective cohort design, including Veterans with diabetes registered for the My Health e Vet patient portal who had not yet used the Web-based refill or ...


Airway Smooth Muscle Pathology In Pompe Disease, Lang Xiong, Allison M. Keeler, Donghai Lui, Kaitlyn Desrochers, Ronghua Zhuge, Mai K. Elmallah 2016 University of Massachusetts Medical School

Airway Smooth Muscle Pathology In Pompe Disease, Lang Xiong, Allison M. Keeler, Donghai Lui, Kaitlyn Desrochers, Ronghua Zhuge, Mai K. Elmallah

UMass Center for Clinical and Translational Science Research Retreat

Pompe disease is a rare autosomal recessive disease which results from a deficiency of acid α-glucosidase (GAA) - an enzyme that degrades lysosomal glycogen. Patients with Pompe disease develop intra-lysosomal accumulation of glycogen in multiple tissues including skeletal muscle, CNS and smooth muscle.

Pulmonary dysfunction is a hallmark of Pompe disease and has classically been attributed to muscle weakness and CNS neuropathology. However, the potential role of respiratory smooth muscles in the respiratory pathology is unknown. Therefore we postulated that GAA deficiency results in airway smooth muscle glycogen accumulation that leads to airway smooth muscle dysfunction.

Using the Pompe mouse model ...


Electronic Communication Systems: Energizing The Patient With Diabetes To Engage In Their Own Health Care, Michael J. Thompson 2016 University of Massachusetts Medical School

Electronic Communication Systems: Energizing The Patient With Diabetes To Engage In Their Own Health Care, Michael J. Thompson

UMass Center for Clinical and Translational Science Research Retreat

As part of the mini-symposium entitled "Interdiscipllinary Mobile Health and Sensing Research," Dr. Thompson discusses his work in mobile diabetes monitoring.


The Impact Of Polybrominated Diphenyl Ether (Bde-47) Administration In Mice And Its Implications In Non-Alcoholic Fatty Liver Disease, Kristen Ciampi 2016 University of Rhode Island

The Impact Of Polybrominated Diphenyl Ether (Bde-47) Administration In Mice And Its Implications In Non-Alcoholic Fatty Liver Disease, Kristen Ciampi

Senior Honors Projects

Non-alcoholic fatty liver disease (NAFLD) is a disease characterized by the accumulation of fat in liver cells that is not due to alcohol consumption. Steatosis results when more than 5-10% of the liver’s weight consists of fat. People who are overweight, or who have diabetes or high cholesterol are more likely to develop NAFLD. Over time, NAFLD can advance to cause cirrhosis, and eventually, liver cancer or failure.

Polybrominated diphenyl ethers (PBDEs, BDEs) are brominated flame- retardants, and are found in many plastics and household products such as cars, textiles, televisions, and computers. BDEs are released into the environment ...


Uric Acid-Induced Adipocyte Dysfunction Is Attenuated By Ho-1 Upregulation: Potential Role Of Antioxidant Therapy To Target Obesity, Komal Sodhi, Jordan Hilgefort, George Banks, Chelsea Gilliam, Sarah Stevens, Hayden A. Ansinelli, Morghan Getty, Nader G. Abraham, Joseph I. Shapiro, Zeid J. Khitan 2016 Marshall University

Uric Acid-Induced Adipocyte Dysfunction Is Attenuated By Ho-1 Upregulation: Potential Role Of Antioxidant Therapy To Target Obesity, Komal Sodhi, Jordan Hilgefort, George Banks, Chelsea Gilliam, Sarah Stevens, Hayden A. Ansinelli, Morghan Getty, Nader G. Abraham, Joseph I. Shapiro, Zeid J. Khitan

Nader G. Abraham

Increased uric acid levels have been implicated in the pathogenesis of metabolic syndrome. To examine the mechanisms by which this occurs, we hypothesized that an increase in heme oxygenase 1, a potent antioxidant gene, will decrease uric acid levels and adipocyte dysfunction via suppression of ROS and xanthine oxidase (XO) levels.We examined the effect of uric acid on adipogenesis in human mesenchymal stem cells (MSCs) in the presence and absence of cobalt protoporphyrin (CoPP), an HO-1 inducer, and tin mesoporphyrin (SnMP), an HO activity inhibitor. Uric acid increased adipogenesis by increasing NADPH oxidase expression and elevation in the adipogenesis ...


Uric Acid-Induced Adipocyte Dysfunction Is Attenuated By Ho-1 Upregulation: Potential Role Of Antioxidant Therapy To Target Obesity, Komal Sodhi, Jordan Hilgefort, George Banks, Chelsea Gilliam, Sarah Stevens, Hayden A. Ansinelli, Morghan Getty, Nader G. Abraham, Joseph I. Shapiro, Zeid J. Khitan 2016 Marshall University

Uric Acid-Induced Adipocyte Dysfunction Is Attenuated By Ho-1 Upregulation: Potential Role Of Antioxidant Therapy To Target Obesity, Komal Sodhi, Jordan Hilgefort, George Banks, Chelsea Gilliam, Sarah Stevens, Hayden A. Ansinelli, Morghan Getty, Nader G. Abraham, Joseph I. Shapiro, Zeid J. Khitan

Komal Sodhi

Increased uric acid levels have been implicated in the pathogenesis of metabolic syndrome. To examine the mechanisms by which this occurs, we hypothesized that an increase in heme oxygenase 1, a potent antioxidant gene, will decrease uric acid levels and adipocyte dysfunction via suppression of ROS and xanthine oxidase (XO) levels.We examined the effect of uric acid on adipogenesis in human mesenchymal stem cells (MSCs) in the presence and absence of cobalt protoporphyrin (CoPP), an HO-1 inducer, and tin mesoporphyrin (SnMP), an HO activity inhibitor. Uric acid increased adipogenesis by increasing NADPH oxidase expression and elevation in the adipogenesis ...


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