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Immunosuppressive Treatment And The Risk Of Diabetes In Rheumatoid Arthritis, Siri Lillegraven, Jeffrey D. Greenberg, George W. Reed, Katherine Saunders, Jeffrey R. Curtis, Leslie R. Harrold, Marc C. Hochberg, Dimitrios A. Pappas, Joel M. Kremer, Daniel H. Solomon 2019 Diakonhjemmet Hospital

Immunosuppressive Treatment And The Risk Of Diabetes In Rheumatoid Arthritis, Siri Lillegraven, Jeffrey D. Greenberg, George W. Reed, Katherine Saunders, Jeffrey R. Curtis, Leslie R. Harrold, Marc C. Hochberg, Dimitrios A. Pappas, Joel M. Kremer, Daniel H. Solomon

Leslie R. Harrold

OBJECTIVE: Inflammation and anti-inflammatory treatments might influence the risk of diabetes. The objective of this study was to assess factors associated with incident diabetes in rheumatoid arthritis (RA).

METHODS: The study population consisted of RA patients from a multi-center cohort study, Corrona. To assess risk associated with disease modifying antirheumatic drug (DMARD) exposure, we assessed five mutually exclusive DMARD groups. Additionally, we assessed the risk associated with body mass index (BMI, < 25, 25-30, > 30 kg/m2) and glucocorticoid usage. Incident cases of diabetes were confirmed through adjudication, and Cox regression models were fit to estimate the risk of incident diabetes.

RESULTS: We ...


Paleolithic Ketogenic Diet (Pkd) In Chronic Diseases: Clinical And Research Data, Zsófia Clemens, Csaba Tóth 2019 International Center for Medical Nutritional Intervention (ICMNI) – Paleomedicina Hungary

Paleolithic Ketogenic Diet (Pkd) In Chronic Diseases: Clinical And Research Data, Zsófia Clemens, Csaba Tóth

Journal of Evolution and Health

No abstract provided.


Diabetic Neuropathic Foot Without Neuropathy: Could It Be Cancer? - A Case Report, Jennifer Baima, Felix Santiago, Mathew J. Most 2019 University of Massachusetts Medical School

Diabetic Neuropathic Foot Without Neuropathy: Could It Be Cancer? - A Case Report, Jennifer Baima, Felix Santiago, Mathew J. Most

Orthopedics and Physical Rehabilitation Publications and Presentations

We present a case of a 64 year-old diabetic male who presented with months of progressively worsening foot pain and swelling, who was initially diagnosed with Charcot joint disease.(CJD) He was ultimately found to have a very rare tumor.


Traditional And Nontraditional Risks For Kidney Disease: A Comparison Of Western And Paleolithic-Type Diets, lynda frassetto 2019 UCSF

Traditional And Nontraditional Risks For Kidney Disease: A Comparison Of Western And Paleolithic-Type Diets, Lynda Frassetto

Journal of Evolution and Health

No abstract provided.


Health Literacy And Type 2 Diabetes In Barbados, Coralene Quimby-Worrell 2019 University of Phoenix

Health Literacy And Type 2 Diabetes In Barbados, Coralene Quimby-Worrell

The Qualitative Report

IIn this qualitative instrumental single case study, I explored how patients living with Type 2 diabetes (T2D) in Barbados manage the disease and what role health literacy might play. Purposeful sampling aided in selecting the sample for the study. The sample was 23 participants who were 40 years and older, diagnosed with T2D, living in Barbados, and attending the Endocrine Center for treatment. Participants responded to 13 open ended questions used to answer the research questions. Information was coded using NVivo 10 software and the software provided the themes based on the participants’ responses to the interview questions. The ...


Innovation And Competition In Advanced Therapy Medicinal Products, Enrique Seoane-Vazquez, Vaishali Shukla, Rosa Rodriguez-Monguio 2019 Chapman University

Innovation And Competition In Advanced Therapy Medicinal Products, Enrique Seoane-Vazquez, Vaishali Shukla, Rosa Rodriguez-Monguio

Pharmacy Faculty Articles and Research

"Advanced therapy medicinal products (ATMPs), including gene therapy, cell therapy, and tissue engineering products, represent a paradigm shift in health care as they have great potential for preventing and treating many diseases (Food and Drug Administration (FDA), 2013). By way of example, only 367 (8.0%) of the 4,603 rare diseases and conditions listed by the NIH Genetic and Rare Diseases Information Center had at least one FDA-approved drug therapy in early 2018. An estimated 3,038 (66.0%) of those rare diseases and conditions are congenital and genetic diseases that could potentially be treated by gene therapy. There ...


Immunosuppressive Treatment And The Risk Of Diabetes In Rheumatoid Arthritis, Siri Lillegraven, Jeffrey D. Greenberg, George W. Reed, Katherine Saunders, Jeffrey R. Curtis, Leslie R. Harrold, Marc C. Hochberg, Dimitrios A. Pappas, Joel M. Kremer, Daniel H. Solomon 2019 Diakonhjemmet Hospital

Immunosuppressive Treatment And The Risk Of Diabetes In Rheumatoid Arthritis, Siri Lillegraven, Jeffrey D. Greenberg, George W. Reed, Katherine Saunders, Jeffrey R. Curtis, Leslie R. Harrold, Marc C. Hochberg, Dimitrios A. Pappas, Joel M. Kremer, Daniel H. Solomon

Open Access Articles

OBJECTIVE: Inflammation and anti-inflammatory treatments might influence the risk of diabetes. The objective of this study was to assess factors associated with incident diabetes in rheumatoid arthritis (RA).

METHODS: The study population consisted of RA patients from a multi-center cohort study, Corrona. To assess risk associated with disease modifying antirheumatic drug (DMARD) exposure, we assessed five mutually exclusive DMARD groups. Additionally, we assessed the risk associated with body mass index (BMI, < 25, 25-30, > 30 kg/m2) and glucocorticoid usage. Incident cases of diabetes were confirmed through adjudication, and Cox regression models were fit to estimate the risk of incident diabetes.

RESULTS: We ...


Human Islets Expressing Hnf1a Variant Have Defective Beta Cell Transcriptional Regulatory Networks, Rachana Haliyur, Sambra D. Redick, David M. Harlan, Alvin C. Powers 2019 Vanderbilt University

Human Islets Expressing Hnf1a Variant Have Defective Beta Cell Transcriptional Regulatory Networks, Rachana Haliyur, Sambra D. Redick, David M. Harlan, Alvin C. Powers

Open Access Articles

Using an integrated approach to characterize the pancreatic tissue and isolated islets from a 33-year-old with 17 years of type 1 diabetes (T1D), we found that donor islets contained beta cells without insulitis and lacked glucose-stimulated insulin secretion despite a normal insulin response to cAMP-evoked stimulation. With these unexpected findings for T1D, we sequenced the donor DNA and found a pathogenic heterozygous variant in the gene encoding hepatocyte nuclear factor-1alpha (HNF1A). In one of the first studies of human pancreatic islets with a disease-causing HNF1A variant associated with the most common form of monogenic diabetes, we found that HNF1A dysfunction ...


Toll-Like Receptor-4 Disruption Suppresses Adipose Tissue Remodeling And Increases Survival In Cancer Cachexia Syndrome, Felipe Henriques, Magno A. Lopes, Felipe O. Franco, Pamela Knobl, Kaltinaitis B. Santos, Luana L. Bueno, Victor A. Correa, Alexander H. Bedard, Adilson L. Guilherme, Alexander Birbrair, Sidney B. Peres, Stephen R. Farmer, Miguel L. Batista Jr. 2018 University of Massachusetts Medical School

Toll-Like Receptor-4 Disruption Suppresses Adipose Tissue Remodeling And Increases Survival In Cancer Cachexia Syndrome, Felipe Henriques, Magno A. Lopes, Felipe O. Franco, Pamela Knobl, Kaltinaitis B. Santos, Luana L. Bueno, Victor A. Correa, Alexander H. Bedard, Adilson L. Guilherme, Alexander Birbrair, Sidney B. Peres, Stephen R. Farmer, Miguel L. Batista Jr.

Open Access Articles

Cancer-induced cachexia, characterized by systemic inflammation, body weight loss, adipose tissue (AT) remodeling and muscle wasting, is a malignant metabolic syndrome with undefined etiology. Here, we show that both genetic ablation and pharmacological inhibition of TLR4 were able to attenuate the main clinical markers of cachexia in mice bearing Lewis lung carcinoma (LLC). AT remodelling was not found in LLC tumor-bearing (TB) TLR4(-/-) mice due to reduced macrophage infiltration and adipocyte atrophy. TLR4(-/-) mice were also resistant to cold-induced browning of subcutaneous AT (scAT). Importantly, pharmacological inhibition of TLR4 (Atorvastatin) reproduced the main protective effect against AT remodeling found in ...


Epidermal Growth Factor Receptor (Egfr) Inhibition By Polychlorinated Biphenyls Contributes To Non-Alcoholic Fatty Liver Disease (Nafld)., Josiah Hardesty 2018 University of Louisville

Epidermal Growth Factor Receptor (Egfr) Inhibition By Polychlorinated Biphenyls Contributes To Non-Alcoholic Fatty Liver Disease (Nafld)., Josiah Hardesty

Electronic Theses and Dissertations

This dissertation describes how poly-chlorinated biphenyls (PCBs) exacerbate the pathogenesis of non-alcoholic fatty liver disease (NAFLD). While PCBs were banned in 1979, they still persist in contaminated biota, including food, and are detected in human plasma and adipose. The body burden of PCBs is associated with elevation of liver enzymes and necrosis markers in humans, characteristic of NAFLD. PCB exposure in high-fat diet fed mice leads to steatohepatitis that recapitulate the findings seen in exposed humans. The global estimate of people diagnosed with NAFLD is up to 1 in 4 people, unrelated to dietary or genetic factors. The hepatic mechanisms ...


Effects Of Hydrogen Sulfide In Hyperhomocysteinemia-Mediated Skeletal Muscle Myopathy., Avisek Majumder 2018 University of Louisville

Effects Of Hydrogen Sulfide In Hyperhomocysteinemia-Mediated Skeletal Muscle Myopathy., Avisek Majumder

Electronic Theses and Dissertations

Although hyperhomocysteinemia (HHcy) occurs due to a deficiency in cystathionine-β-synthase (CBS), causing skeletal muscle myopathy, it is still unclear whether this effect is mediated through oxidative, endoplasmic reticulum (ER) stress, both or something else. Cystathionine γ-lyase (CSE) and CBS are the main H2S producing enzymes, which produce Hydrogen sulfide (H2S) from Hcy in the transsulfuration reaction. H2S is an anti-oxidant compound and patients with a CBS deficiency cannot produce enough H2S, thus rendering them vulnerable to excess Hcy-mediated damage. Both in-vitro (C2C12 cells) and in-vivo (CBS+/- mice) models were used to study ...


Orotic Aciduria, Aliah L. Fonteh 2018 Liberty University

Orotic Aciduria, Aliah L. Fonteh

Fidei et Veritatis: The Liberty University Journal of Graduate Research

Orotic acid is an intermediate found in the pathway for pyrimidine synthesis. The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) catalyzes the production of orotic acid by the conversion of the compound dihydroorotate to orotic acid. Orotic acid is commonly produced by this reaction in erythrocytes, hepatocytes, and kidney cells. Chemical modification of orotic acid in the pyrimidine pathway will generate nucleotides involved in DNA and RNA synthesis. Orotic aciduria can occur as a secondary manifestation due to a defect in an enzyme or transporter within the urea cycle, due to competitive inhibition by anti-cancer drugs such as allopurinol and 6-azauridine, or ...


Human-Like Hyperplastic Prostate With Low Zip1 Induced Solely By Zn Deficiency In Rats., Louise Y. Fong, Ruiyan Jing, Karl J. Smalley, Zi-Xuan Wang, Cristian Taccioli, Sili Fan, Hongping Chen, Hansjuerg Alder, Kay Huebner, John L. Farber, Oliver Fiehn, Carlo M. Croce 2018 Thomas Jefferson University

Human-Like Hyperplastic Prostate With Low Zip1 Induced Solely By Zn Deficiency In Rats., Louise Y. Fong, Ruiyan Jing, Karl J. Smalley, Zi-Xuan Wang, Cristian Taccioli, Sili Fan, Hongping Chen, Hansjuerg Alder, Kay Huebner, John L. Farber, Oliver Fiehn, Carlo M. Croce

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Prostate cancer is a leading cause of cancer death in men over 50 years of age, and there is a characteristic marked decrease in Zn content in the malignant prostate cells. The cause and consequences of this loss have thus far been unknown. We found that in middle-aged rats a Zn-deficient diet reduces prostatic Zn levels (P = 0.025), increases cellular proliferation, and induces an inflammatory phenotype with COX-2 overexpression. This hyperplastic/inflammatory prostate has a human prostate cancer-like microRNA profile, with up-regulation of the Zn-homeostasis-regulating miR-183-96-182 cluster (fold change = 1.41-2.38; P = 0.029-0.0003) and down-regulation of ...


Implementing Universal Lynch Syndrome Screening (Impulss): Protocol For A Multi-Site Study To Identify Strategies To Implement, Adapt, And Sustain Genomic Medicine Programs In Different Organizational Contexts, Alanna Kulchak Rahm, Mara M. Epstein 2018 Geisinger Genomic Medicine Institute

Implementing Universal Lynch Syndrome Screening (Impulss): Protocol For A Multi-Site Study To Identify Strategies To Implement, Adapt, And Sustain Genomic Medicine Programs In Different Organizational Contexts, Alanna Kulchak Rahm, Mara M. Epstein

Open Access Articles

BACKGROUND: Systematic screening of all colorectal tumors for Lynch Syndrome (LS) has been recommended since 2009. Currently, implementation of LS screening in healthcare systems remains variable, likely because LS screening involves the complex coordination of multiple departments and individuals across the healthcare system. Our specific aims are to (1) describe variation in LS screening implementation across multiple healthcare systems; (2) identify conditions associated with both practice variation and optimal implementation; (3) determine the relative effectiveness, efficiency, and costs of different LS screening protocols by healthcare system; and (4) develop and test in a real-world setting an organizational toolkit for LS ...


Development And Validation Of A Weight Literacy Scale In English And Spanish, Monica L. Wang, Tariana V. Little, Christine F. Frisard, Amy Borg, Stephenie C. Lemon, Milagros C. Rosal 2018 Boston University

Development And Validation Of A Weight Literacy Scale In English And Spanish, Monica L. Wang, Tariana V. Little, Christine F. Frisard, Amy Borg, Stephenie C. Lemon, Milagros C. Rosal

Open Access Articles

OBJECTIVES: To develop and validate a Weight Literacy Scale in English and Spanish for adults.

METHODS: The two-phase study utilized quantitative and qualitative methods. Phase 1 of the study consisted of developing an initial survey (English and Spanish versions) assessing weight literacy based on a review of the literature; conducting semi-structured interviews with content experts (N = 9) to refine survey items; and conducting in-person cognitive interviews with 20 study participants (N = 10 English-speaking and N = 10 Spanish-speaking adults) for survey pre-testing. Survey items were modified based on Phase 1 findings. Phase 2 consisted of a psychometric study of the Weight ...


Hyperglycemia And Risk Of Ventricular Tachycardia Among Patients Hospitalized With Acute Myocardial Infarction, Hoang V. Tran, Joel M. Gore, Chad E. Darling, Arlene S. Ash, Catarina I. Kiefe, Robert J. Goldberg 2018 University of Massachusetts Medical School

Hyperglycemia And Risk Of Ventricular Tachycardia Among Patients Hospitalized With Acute Myocardial Infarction, Hoang V. Tran, Joel M. Gore, Chad E. Darling, Arlene S. Ash, Catarina I. Kiefe, Robert J. Goldberg

Open Access Articles

BACKGROUND: Little is known about the association of hyperglycemia Tranwith the development of ventricular tachycardia (VT) in patients hospitalized with acute myocardial infarction (AMI) which we examined in the present study. The objectives of this community-wide observational study were to examine the relation between elevated serum glucose levels at the time of hospital admission for AMI and occurrence of VT, and time of occurrence of VT, during the patient's acute hospitalization.

METHODS: We used data from a population-based study of patients hospitalized with AMI at all central Massachusetts medical centers between 2001 and 2011. Hyperglycemia was defined as a ...


Substantial Increase In Compliance With Saturated Fatty Acid Intake Recommendations After One Year Following The American Heart Association Diet, Miaomiao Zhao, David E. Chiriboga, Barbara C. Olendzki, Bin Xie, Yawen Li, Lisa Jo McGonigal, Ana Maldonado-Contreras, Yunsheng Ma 2018 University of Massachusetts Medical School

Substantial Increase In Compliance With Saturated Fatty Acid Intake Recommendations After One Year Following The American Heart Association Diet, Miaomiao Zhao, David E. Chiriboga, Barbara C. Olendzki, Bin Xie, Yawen Li, Lisa Jo Mcgonigal, Ana Maldonado-Contreras, Yunsheng Ma

Open Access Articles

The American Heart Association (AHA) dietary guidelines recommend 30(-)35% of energy intake (%E) be from total fat, < 7%E from saturated fatty acids (SFA), and < 1%E from trans fatty acid (TFA). This study evaluates the effect of AHA dietary counselling on fat intake. Between 2009 and 2014, 119 obese adults with metabolic syndrome (MetS), (71% women, average 52.5 years of age, and 34.9 kg/m(2) of body mass index), received individual and group counselling on the AHA diet, over a one-year study period. Each participant attended 2 individual sessions (months 1 and 12) and 12 group sessions, at one-month intervals. At baseline and one-year, we collected three random 24-h diet recalls (two weekdays and one weekend day). Fat intake patterns over time were analyzed using paired-t test and linear mixed-effect models. There was significant variation on SFA and TFA intake per meal, being highest at dinner, in restaurants, and on weekends. Over the one-year study period, daily intake of total fat, SFA, and TFA decreased by 27%, 37% and 41%, respectively (p-value < 0.01, each). Correspondingly, the percentage of participants complying with AHA's recommendations, increased from 25.2% to 40.2% for total fat (p-value = 0.02); from 2.5% to 20.7% for SFA (p-value < 0.01); and from 45.4% to 62% for TFA (p-value = 0.02). Additionally, SFA intake for all meal types at home decreased significantly (p-value < 0.05, each). AHA dietary counselling significantly increased the compliance with AHA dietary guidelines, with an eightfold increase in compliance in SFA intake. Nonetheless, ~80% of our participants still exceeded the recommended SFA intake. Substantial efforts are needed to encourage low-SFA and low-TFA food preparation at home, with strong public health policies to decrease SFA and TFA in restaurants and prepared foods.


Unhealthy Lifestyle And The Risk Of Metabolic Syndrome- The Romanian Experience, Angela Cozma, Adela Sitar-Taut, Laura Urian, Adriana Fodor, Ramona Suharoschi, Crina Muresan, Vasile Negrean, Dorel Sampelean, Dumitru Zdrenghea, Dana Pop, Leucuta Daniel, Olga Hilda Orasan 2018 Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4 th Department of Internal Medicine, Cluj-Napoca, Romania

Unhealthy Lifestyle And The Risk Of Metabolic Syndrome- The Romanian Experience, Angela Cozma, Adela Sitar-Taut, Laura Urian, Adriana Fodor, Ramona Suharoschi, Crina Muresan, Vasile Negrean, Dorel Sampelean, Dumitru Zdrenghea, Dana Pop, Leucuta Daniel, Olga Hilda Orasan

Journal of Mind and Medical Sciences

Background. Metabolic syndrome (MetS) represents a clustering of metabolic risk factors for cardiovascular disease. Many studies have shown the influence of an unhealthy lifestyle on the risk of MetS, yet some aspects remain controversial. Aim of the study: to investigate the relationship between an unhealthy lifestyle and the risk of MetS.

Materials and Methods. The study was conducted using a sample of 181 patients, 54 (29.8%) males and 127 (70.2%) females, aged 59.95±10.8 years. The baseline survey involved the completion of structured questionnaires and clinical examination.

Results. Rural environment, lower education level, past smoking, the ...


Justice Served Fresh: Associations Between Food Insecurity, Community Gardening, And Property Value, Micajah Daniels, Courtney Coughenour PhD 2018 University of Nevada, Las Vegas

Justice Served Fresh: Associations Between Food Insecurity, Community Gardening, And Property Value, Micajah Daniels, Courtney Coughenour Phd

McNair Poster Presentations

Numerous stakeholders in Nevada have used a variety of efforts to combat the growth of food insecurity facing Nevadans. The purpose of this research project is to understand the association between food insecurity, community gardens, and property value. Following the wealth of scholarship on these topics and data collected from community garden agencies in Southern Nevada, the research questions for this project include: (1) Where are community gardens located in SNV? (2) What efforts community gardens agencies are doing to address food insecurity (most interested in their efforts using community gardens)? (3) What are the perceptions of supports and barriers ...


Prevalence And Management Of Iron Overload In Pyruvate Kinase Deficiency: Report From The Pyruvate Kinase Deficiency Natural History Study, Eduard J. van Beers, Peter E. Newburger, Rachael F. Grace 2018 University Medical Center Utrecht

Prevalence And Management Of Iron Overload In Pyruvate Kinase Deficiency: Report From The Pyruvate Kinase Deficiency Natural History Study, Eduard J. Van Beers, Peter E. Newburger, Rachael F. Grace

Open Access Articles

Pyruvate kinase (PK) deficiency is the most common red cell glycolytic enzyme defect causing hereditary non-spherocytic hemolytic anemia. Current treatments are mainly supportive and include red cell transfusions and splenectomy.11 Regular red cell transfusions are known to result in iron overload; however, the prevalence and spectrum of transfusion-independent iron overload in the overall PK deficient population has not been well defined. This analysis describes the prevalence and clinical characteristics of iron overload in patients enrolled in the PK Deficiency Natural History Study (NHS) with a focus on those patients who are not regularly transfused.2


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