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Nutritional and Metabolic Diseases Commons

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Exploring Autonomy Support In Shared Decision Making And Patient Activation Of Diabetes Self-Care Behaviors, Carol Mahler Hamersky 2017 Seton Hall University

Exploring Autonomy Support In Shared Decision Making And Patient Activation Of Diabetes Self-Care Behaviors, Carol Mahler Hamersky

Seton Hall University Dissertations and Theses (ETDs)

Introduction:

Chronic disease places a different set of demands on an individual and family. Self-care behaviors and daily decision making is an integral part of diabetes management. According to the CDC (2014), the prevalence of Diabetes is estimated at 29.1 million and an alarming 86 million Americans have Pre-diabetes. Despite a plethora of evidence on the importance of diabetes self-care behaviors on clinical outcomes, studies have highlighted the current disconnect of patients not able to follow self-care behavior recommendations and not asking for help from their health care providers. There is no literature on the impact of an autonomy ...


A Mixed-Methods Study: Self-Efficacy And Barriers To Participation In Workplace Wellness Programs, Massiel Perez-Calhoon 2017 Brandman University

A Mixed-Methods Study: Self-Efficacy And Barriers To Participation In Workplace Wellness Programs, Massiel Perez-Calhoon

Dissertations

America needs a healthy workforce to sustain the country. The scourge of obesity continues to plague Americans despite government initiatives such as the Affordable Care Act and wellness programs in the workplace to combat this epidemic. However, despite initiatives to make America healthy, barriers continued to impede the nation’s health. Lack of awareness and sensitivity to what motivates individual participants versus group participants built formidable barriers to accessing all workplace employees equitably. The purpose of this study was twofold. First, the intent of this study was to explore the relationship between self-efficacy and the impact on participation and engagement ...


Tracking Energy Balance In Adolescents: Levels Of Compliance, Energy Flux, And Learning, Senlin Chen, Xihe Zhu, Gregory J. Welk, Youngwon Kim 2017 Old Dominion University

Tracking Energy Balance In Adolescents: Levels Of Compliance, Energy Flux, And Learning, Senlin Chen, Xihe Zhu, Gregory J. Welk, Youngwon Kim

Xihe Zhu

Background/Objective: Advancing knowledge about energy balance (EB) is important for helping to reverse the obesity epidemic in many modern societies. This study examined adolescents' experience and perception of using an objective self-monitoring tool (SenseWear armband; SWA) and a portable diet journal to track EB for 7 days. Methods: Forty-five 6th grade students in a midwestern state of the United States [Caucasian: n = 34, 76%; age: 11.7 ± 1.8 years; body mass index (BMI): 20.84 ± 3.94] participated in the study. The SWA, diet journal, and semistructured individual interview were used to measure energy expenditure (EE) and physical ...


Promotion Of New Diabetes Products In The District Of Columbia, Joy Eckert, Dilpan Sundaramoorthy, Alycia Hogenmiller 2017 George Washington University

Promotion Of New Diabetes Products In The District Of Columbia, Joy Eckert, Dilpan Sundaramoorthy, Alycia Hogenmiller

GW Research Days 2016 - Present

Background: Growth in pharmaceutical expenditures for diabetes outpaced growth in diabetes prevalence. Prescribers accepting gifts and meals from pharmaceutical companies have been linked with higher prescription rates and costs[1]. Pharmaceutical marketing to these prescribers and patients often promotes newer, more expensive drugs, such as the GLP-1 analogues and SGL-2 inhibitors. These two drug classes are more expensive but no more effective than metformin,[2] the recommended first-line treatment for diabetes, and the oldest and cheapest available treatment. We investigated how cost of diabetes treatment was affected by marketing practices in the District of Columbia.

Methods: The AccessRx program in ...


A Novel Approach To The Safe And Effective Mobilization Of A Super-Obese Patient: A Case Report, Jessica Anaf, Amy Wigmore, Kathy Stiller 2017 Royal Adelaide Hospital

A Novel Approach To The Safe And Effective Mobilization Of A Super-Obese Patient: A Case Report, Jessica Anaf, Amy Wigmore, Kathy Stiller

Internet Journal of Allied Health Sciences and Practice

Purpose: The incidence of obesity is rising worldwide, as is the presentation of these patients to the acute hospital setting. As a result of their complex nature, including medical co-morbidities, psychosocial issues, and healthcare resource limitations, management of these patients requires a coordinated and intensive multi-disciplinary approach. Although there are considerable data reporting the surgical management of obese patients, there is very limited literature regarding non-surgical interventions, including approaches to safe and effective mobilization. Methods: A case report is presented of a 55-year-old super-obese male transferred to a major tertiary referral healthcare centre for management of his overall medical condition ...


Diet, Kidney Stones And Kidney Failure, lynda frassetto 2017 UCSF

Diet, Kidney Stones And Kidney Failure, Lynda Frassetto

Journal of Evolution and Health

No abstract provided.


Dietary Refinement And The Upper Gut Microbiota: The Starting Point For Obesity And Non-Communicable Diseases?, Ian Spreadbury 2017 Ancestral Health Society

Dietary Refinement And The Upper Gut Microbiota: The Starting Point For Obesity And Non-Communicable Diseases?, Ian Spreadbury

Journal of Evolution and Health

No abstract provided.


Assessment Of Diet In Patients With Inflammatory Bowel Disease: A Collaboration Of Behavioral And Basic Scientists, Barbara C. Olendzki, Aparna Kohli, Effie Olendzki, YuShuan (Cindy) Lai, Ana Maldonado-Contreras 2017 University of Massachusetts Medical School

Assessment Of Diet In Patients With Inflammatory Bowel Disease: A Collaboration Of Behavioral And Basic Scientists, Barbara C. Olendzki, Aparna Kohli, Effie Olendzki, Yushuan (Cindy) Lai, Ana Maldonado-Contreras

Community Engagement and Research Symposia

Introduction: Clinical research to develop treatment for inflammatory bowel disease (IBD) is focusing on a nutritional regimen restricting certain carbohydrates while incorporating the use of an optimal diet that includes pre- and probiotic foods. Current assessments are not able to measure elements of this nutritional regimen, thus we developed a food frequency questionnaire (FFQ). This FFQ will be utilized in a prospective study of IBD patients following an anti-inflammatory diet (IBD-AID) developed by us and used clinically at UMASS. We will track the bacterial communities inhabiting the microbiome of patients to determine diet-dependent changes, and their relation with patient wellbeing ...


Data From: Predictors Of Lack Of Partial Clinical Remission In New-Onset Pediatric Type 1 Diabetes, Katherine R. Marino, Rachel L. Lundberg, Aastha Jasrotia, Louise S. Maranda, Michael J. Thompson, Bruce A. Barton, Laura C. Alonso, Benjamin U. Nwosu 2017 University of Massachusetts Medical School

Data From: Predictors Of Lack Of Partial Clinical Remission In New-Onset Pediatric Type 1 Diabetes, Katherine R. Marino, Rachel L. Lundberg, Aastha Jasrotia, Louise S. Maranda, Michael J. Thompson, Bruce A. Barton, Laura C. Alonso, Benjamin U. Nwosu

Pediatric Research Data

This dataset is the primary data source for a manuscript submitted for publication.


Ux007 For The Treatment Of Long Chain-Fatty Acid Oxidation Disorders: Safety And Efficacy In Children And Adults Following 24weeks Of Treatment., J Vockley, B Burton, G T Berry, N Longo, J Phillips, Pranoot Tanpaiboon, +several additional authors 2017 George Washington University

Ux007 For The Treatment Of Long Chain-Fatty Acid Oxidation Disorders: Safety And Efficacy In Children And Adults Following 24weeks Of Treatment., J Vockley, B Burton, G T Berry, N Longo, J Phillips, Pranoot Tanpaiboon, +Several Additional Authors

Pediatrics Faculty Publications

BACKGROUND: Long-chain fatty acid oxidation disorders (LC-FAOD) lead to accumulation of high concentrations of potentially toxic fatty acid intermediates. Newborn screening and early intervention have reduced mortality, but most patients continue to experience frequent hospitalizations and significant morbidity despite treatment. The deficient energy state can cause serious liver, muscle, and heart disease, and may be associated with an increased risk of sudden death. Triheptanoin is a medium odd-chain fatty acid. Anaplerotic metabolites of triheptanoin have the potential to replace deficient tricarboxylic acid (TCA) cycle intermediates, resulting in net glucose production as a novel energy source for the treatment of LC-FAOD ...


Piloting An Integrated, Interprofessional Programme For People Living With Type Ii Diabetes: Outcomes And Experiences, Daniel O'Brien, Susan M. McNaughton, Brenda Flood, Jane Morgan, Alexandra Bowmar 2016 Auckland University of Technology

Piloting An Integrated, Interprofessional Programme For People Living With Type Ii Diabetes: Outcomes And Experiences, Daniel O'Brien, Susan M. Mcnaughton, Brenda Flood, Jane Morgan, Alexandra Bowmar

Australian Journal of Clinical Education

This paper reports quantitative and descriptive qualitative findings from a mixed-methods study exploring and evaluating the outcomes and experiences of clients, staff and students piloting an integrated interprofessional programme for community members with type II diabetes. The one-day per week, eight-week programme included interprofessional appointments, group education sessions and case conferences led by students from exercise and nutrition, health promotion, nursing, occupational therapy, oral health, physiotherapy, podiatry and counselling psychology. Participants shared their experiences in individual interviews or focus groups. Client outcomes were evaluated using basic clinical indicators and the Canadian Occupational Performance Measure (COPM) that assesses client goal satisfaction ...


Nk-Cd11c+ Cell Crosstalk In Diabetes Enhances Il-6-Mediated Inflammation During Mycobacterium Tuberculosis Infection, Satyanarayana Swamy Cheekatla, Deepak Tripathi, Sambasivan Venkatasubramanian, Pavan Kumar Nathella, Padmaja Paidipally, Munenori Ishibashi, Elwyn Welch, Amy R. Tvinnereim, Mitsuo Ikebe, Vijaya Lakshmi Valluri, Subash Babu, Hardy Kornfeld, Ramakrishna Vankayalapati 2016 University of Texas Health Science Center at Tyler

Nk-Cd11c+ Cell Crosstalk In Diabetes Enhances Il-6-Mediated Inflammation During Mycobacterium Tuberculosis Infection, Satyanarayana Swamy Cheekatla, Deepak Tripathi, Sambasivan Venkatasubramanian, Pavan Kumar Nathella, Padmaja Paidipally, Munenori Ishibashi, Elwyn Welch, Amy R. Tvinnereim, Mitsuo Ikebe, Vijaya Lakshmi Valluri, Subash Babu, Hardy Kornfeld, Ramakrishna Vankayalapati

Open Access Articles

In this study, we developed a mouse model of type 2 diabetes mellitus (T2DM) using streptozotocin and nicotinamide and identified factors that increase susceptibility of T2DM mice to infection by Mycobacterium tuberculosis (Mtb). All Mtb-infected T2DM mice and 40% of uninfected T2DM mice died within 10 months, whereas all control mice survived. In Mtb-infected mice, T2DM increased the bacterial burden and pro- and anti-inflammatory cytokine and chemokine production in the lungs relative to those in uninfected T2DM mice and infected control mice. Levels of IL-6 also increased. Anti-IL-6 monoclonal antibody treatment of Mtb-infected acute- and chronic-T2DM mice increased survival (to ...


Process Evaluation Of A Patient-Centred, Patientdirected, Group-Based Education Program For The Management Of Type 2 Diabetes Mellitus, Kate Odgers-Jewell, Elisabeth Isenring, Rae Thomas, Dianne P Reidlinger 2016 Bond University

Process Evaluation Of A Patient-Centred, Patientdirected, Group-Based Education Program For The Management Of Type 2 Diabetes Mellitus, Kate Odgers-Jewell, Elisabeth Isenring, Rae Thomas, Dianne P Reidlinger

Faculty of Health Sciences & Medicine Publications

Aim:

The present study developed and evaluated a patient-centred, patient-directed, group-based education program for the management of type 2 diabetes mellitus.

Methods:

Two frameworks, the Medical Research Council (MRC) framework for developing and evaluating complex interventions and the RE-AIM framework were followed. Data to develop the intervention were sourced from scoping of the literature and formative evaluation. Program evaluation comprised analysis of primary recruitment of participants through general practitioners, baseline and end-point measures of anthropometry, four validated questionnaires, contemporaneous facilitator notes and telephone interviews with participants.

Results:

A total of 16 participants enrolled in the intervention. Post-intervention results were obtained ...


Effects Of S1p Mutation On Er Stress And Cholesterol Synthesis Markers In Human Epithelial Cells, Connie Gan, George G. Schweitzer, Rita T. Brookheart, Robert C. Bucelli, Brian N. Finck 2016 Washington University in St. Louis

Effects Of S1p Mutation On Er Stress And Cholesterol Synthesis Markers In Human Epithelial Cells, Connie Gan, George G. Schweitzer, Rita T. Brookheart, Robert C. Bucelli, Brian N. Finck

Undergraduate Research Symposium Posters

Site-1 Protease (S1P) is a Golgi-resident enzyme required for activation and subsequent nuclear localization of several major transcription factors. A 24-year-old female patient with a de novo single point mutation in S1P presented with a complex phenotype of gut hypomotility, abnormal optic nerves, and polycystic ovarian syndrome. Furthermore, this patient suffers from phenotypes related to skeletal muscle dysfunction, resulting in decreased ability to perform physical exercise due to unusual post-exercise pain, fatigue, nausea, and vomiting. This phenomenon has been described in the literature to manifest from myoedema and the breakdown of muscle that releases intracellular proteins into the blood, or ...


Independent Effects Of Diet And Exercise Training On Fat Oxidation In Non-Alcoholic Fatty Liver Disease., Ilaria Croci, Nuala M Byrne, Veronique S Chachay, Andrew P Hills, Andrew D Clouston, Trisha M O'Moore-Sullivan, Johannes B Prins, Graeme A Macdonald, Ingrid J Hickman 2016 University of Queensland

Independent Effects Of Diet And Exercise Training On Fat Oxidation In Non-Alcoholic Fatty Liver Disease., Ilaria Croci, Nuala M Byrne, Veronique S Chachay, Andrew P Hills, Andrew D Clouston, Trisha M O'Moore-Sullivan, Johannes B Prins, Graeme A Macdonald, Ingrid J Hickman

Faculty of Health Sciences & Medicine Publications

AIM:

To investigate the independent effects of 6-mo of dietary energy restriction or exercise training on whole-body and hepatic fat oxidation of patients with non-alcoholic fatty liver disease (NAFLD).

METHODS:

Participants were randomised into either circuit exercise training (EX; n = 13; 3 h/wk without changes in dietary habits), or dietary energy restriction (ER) without changes in structured physical activity (ER; n = 8). Respiratory quotient (RQ) and whole-body fat oxidation rates (Fatox) were determined by indirect calorimetry under basal, insulin-stimulated and exercise conditions. Severity of disease and steatosis was determined by liver histology; hepatic Fatox was estimated from plasma β-hydroxybutyrate ...


An Evaluation Of African American Fathers’ Perceptions And Influences On Child Food Choices And Physical Activity Behaviors, Valerie Annette Richardson 2016 University of Southern Mississippi

An Evaluation Of African American Fathers’ Perceptions And Influences On Child Food Choices And Physical Activity Behaviors, Valerie Annette Richardson

Dissertations

Child obesity is affecting children’s health nationwide. Rates are highest among African Americans (AA) in the South. Research has explored parents’ influence on child eating and activity, but most has reported on mothers’ influences. The purpose of this research was to investigate perceptions about AA fathers’ influences on their children’s eating and physical activity. Using a structured focus group questionnaire based on the parent layer constructs of Birch and Ventura’s Ecological Model for Child Overweight (2009), four focus groups were conducted with 28 AA fathers with children 6- to 11-years-old in a rural and an urban church ...


Sustained Use Of Patient Portal Features And Improvements In Diabetes Physiological Measures, Stephanie L. Shimada, Jeroan J. Allison, Amy K. Rosen, Hua Feng, Thomas K. Houston 2016 University of Massachusetts Medical School

Sustained Use Of Patient Portal Features And Improvements In Diabetes Physiological Measures, Stephanie L. Shimada, Jeroan J. Allison, Amy K. Rosen, Hua Feng, Thomas K. Houston

University of Massachusetts Medical School Faculty Publications

BACKGROUND: Personal health records (PHRs) have the potential to improve patient self-management for chronic conditions such as diabetes. However, evidence is mixed as to whether there is an association between PHR use and improved health outcomes.

OBJECTIVE: The aim of this study was to evaluate the association between sustained use of specific patient portal features (Web-based prescription refill and secure messaging-SM) and physiological measures important for the management of type 2 diabetes.

METHODS: Using a retrospective cohort design, including Veterans with diabetes registered for the My Health e Vet patient portal who had not yet used the Web-based refill or ...


Airway Smooth Muscle Pathology In Pompe Disease, Lang Xiong, Allison M. Keeler, Donghai Lui, Kaitlyn Desrochers, Ronghua Zhuge, Mai K. Elmallah 2016 University of Massachusetts Medical School

Airway Smooth Muscle Pathology In Pompe Disease, Lang Xiong, Allison M. Keeler, Donghai Lui, Kaitlyn Desrochers, Ronghua Zhuge, Mai K. Elmallah

UMass Center for Clinical and Translational Science Research Retreat

Pompe disease is a rare autosomal recessive disease which results from a deficiency of acid α-glucosidase (GAA) - an enzyme that degrades lysosomal glycogen. Patients with Pompe disease develop intra-lysosomal accumulation of glycogen in multiple tissues including skeletal muscle, CNS and smooth muscle.

Pulmonary dysfunction is a hallmark of Pompe disease and has classically been attributed to muscle weakness and CNS neuropathology. However, the potential role of respiratory smooth muscles in the respiratory pathology is unknown. Therefore we postulated that GAA deficiency results in airway smooth muscle glycogen accumulation that leads to airway smooth muscle dysfunction.

Using the Pompe mouse model ...


Electronic Communication Systems: Energizing The Patient With Diabetes To Engage In Their Own Health Care, Michael J. Thompson 2016 University of Massachusetts Medical School

Electronic Communication Systems: Energizing The Patient With Diabetes To Engage In Their Own Health Care, Michael J. Thompson

UMass Center for Clinical and Translational Science Research Retreat

As part of the mini-symposium entitled "Interdiscipllinary Mobile Health and Sensing Research," Dr. Thompson discusses his work in mobile diabetes monitoring.


The Impact Of Polybrominated Diphenyl Ether (Bde-47) Administration In Mice And Its Implications In Non-Alcoholic Fatty Liver Disease, Kristen Ciampi 2016 University of Rhode Island

The Impact Of Polybrominated Diphenyl Ether (Bde-47) Administration In Mice And Its Implications In Non-Alcoholic Fatty Liver Disease, Kristen Ciampi

Senior Honors Projects

Non-alcoholic fatty liver disease (NAFLD) is a disease characterized by the accumulation of fat in liver cells that is not due to alcohol consumption. Steatosis results when more than 5-10% of the liver’s weight consists of fat. People who are overweight, or who have diabetes or high cholesterol are more likely to develop NAFLD. Over time, NAFLD can advance to cause cirrhosis, and eventually, liver cancer or failure.

Polybrominated diphenyl ethers (PBDEs, BDEs) are brominated flame- retardants, and are found in many plastics and household products such as cars, textiles, televisions, and computers. BDEs are released into the environment ...


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