Neurorretinitis Por Arañazo De Gato: A Propósito De Un Caso, 2022 Universidad El Bosque
Neurorretinitis Por Arañazo De Gato: A Propósito De Un Caso, Fernando Godín Estrada, Eduardo Enrique Cadena Galvis, Laura Alejandra Acevedo Espitia, Diana Valeria Rey-Rodríguez
Ciencia y Tecnología para la Salud Visual y Ocular
La enfermedad por arañazo de gato es una zoonosis distribuida por todo el mundo. En esa condición, los gatos son el reservorio primario de Bartonella henselae, siendo la pulga del gato (Ctenocephalides felis) el principal vector entre ellos. Dicha enfermedad se caracteriza por manifestaciones sistémicas predominantes en el cerebro, el ojo, el hígado, el bazo y el hueso. En este estudio se presenta el caso de una paciente femenina de 29 años, quien consultó por disminución de agudeza visual (AV) y dolor ocular pulsátil de intensidad 8/10, según la escala visual análoga (EVA) en el ojo izquierdo (OI), sin síntomas …
A Reactivation Of Ocular Toxoplasmosis During Pregnancy, 2022 Department of Veterans Affairs
A Reactivation Of Ocular Toxoplasmosis During Pregnancy, Brett Garee Od, Ms, Sarah Dieter Od, Pete Liette Od
Optometric Clinical Practice
Background: Toxoplasma gondii is a parasite estimated to affect over 500 million people worldwide. The feline is the definitive host for the parasite and infection may be acquired or congenital via maternal transmission. Humans may acquire the infection by ingestion of raw or undercooked meats and vegetables, contaminated water, or exposure to infected cat feces. The infection is often benign, self-limiting, and asymptomatic for humans, but potentially life threatening to infants or the immunocompromised patient.
Case Report: A 22 year-old Caucasian female, pregnant at 12 weeks gestation, presented to the optometry service with acute symptoms of hazy vision …
Factors Influencing Fellowship Training Among Ophthalmology Residents: A Pilot Study, 2022 Grant Medical Center
Factors Influencing Fellowship Training Among Ophthalmology Residents: A Pilot Study, Craig Czyz, Rahul Kashyap, Laura L. Wayman
HCA Healthcare Journal of Medicine
There has been an increase in ophthalmology fellowship training programs and applicants. The current ophthalmology literature lacks any recent study examining factors influencing residents' decisions to pursue subspecialty fellowship training.
An anonymous, 16-item survey was distributed to residents from a convenience sample of ophthalmology residency programs by their program directors or administrators.
A total of 72 residents and 9 interns from 9 distinct programs completed the survey. Eighty-two percent of respondents reported they have either applied or will apply for a fellowship position. Gender and race showed no significant association with fellowship application. Respondents perceived that obtaining …
Innovative Therapeutic Approach To Chemical Burns Produced By Vesicants; An Experimental Study, 2022 Cantacuzino” National Medical-Military Research-Development Institute 050096 Bucharest, Romania
Innovative Therapeutic Approach To Chemical Burns Produced By Vesicants; An Experimental Study, Cristina Anca Secara, Otilia Liudmila Cinteza, Diana Popescu, Claudia Valentina Popa, Camelia Andreea Hirjeu, Oana Cristina Voinea, Luiza Georgia Serbanescu, Andreea Marilena Pauna, Mihail Tudosie
Journal of Mind and Medical Sciences
Vesicants are compounds that cause severe toxic effects on various tissues. Such chemical action causes tissue necrosis, with clinical expression of skin lesions with a burning character and characteristic blisters. Clinical toxic effects of cutaneous vesicles are correlated with the absorbed dose and exposure time. The goals of the study are to evaluate in vitro the skin toxicity produced by the vesicant chemical compound 2-chloroethyl-ethyl sulfide (CEES), to develop a complex antidote formula, and to optimize the therapeutic efficacy by inclusion in controlled release systems. The experimental protocol aims at the in vitro evaluation of the cytotoxicity of the vesicant …
Age Related Macular Degeneration, 2022 Gettysburg College
Age Related Macular Degeneration, Kathryn J. Hopsicker
This paper is a literature review on the subject Age-Related Macular Degeneration (AMD) with a focus on its etiology, pathophysiology, clinical features, diagnosis, treatment, and prevention. AMD is the leading cause of severe and irreversible central vision loss in in individuals over the age of 55. There are two subtypes of AMD referred to as dry and wet respectively. The etiology of this disease is multifactorial and complex, with no hallmark of disease definitively identified. The distinct pathophysiological features differing in dry and wet AMD are explored in this review as well as its diagnosis and treatment. This disease is …
The Effects Of Cannabidiol On Aqueous Humor Outflow And Trabecular Meshwork Cell Signaling, 2022 University of Louisville
The Effects Of Cannabidiol On Aqueous Humor Outflow And Trabecular Meshwork Cell Signaling, Alyssa S. Aebersold, Zhao-Hui Song
Intraocular pressure (IOP) is regulated primarily through aqueous humor production by ciliary body and drainage through uveoscleral and trabecular meshwork (TM) tissues. The goal of this study was to measure the effect of non-psychotropic cannabidiol (CBD) on aqueous humor outflow through TM and assess the effect of CBD on the TM cell signaling pathways that are important for regulating outflow. Perfused porcine eye anterior segment explants were used to investigate the effects of CBD on aqueous humor outflow. Cultured porcine TM cells were used to study the effects of CBD on TM cell contractility, myosin light chain (MLC) and myosin …
Wellness Study: Functional Visual Outcomes In Eye Disease Patients Following The Covid-19 Pandemic, 2022 Western University
Wellness Study: Functional Visual Outcomes In Eye Disease Patients Following The Covid-19 Pandemic, Andrew Maher
Undergraduate Student Research Internships Conference
The COVID-19 pandemic has caused delays in health services and medical appointments, affecting approximately one in three Canadian adults. Elderly eye disease patients experienced delays in treatment for eye conditions including cataracts, glaucoma, and retinal diseases. The impact of these delays on functional visual outcomes and general health rating of elderly patients is not well understood. As part of the Wellness Study, we aimed to investigate the pandemic-related impacts on functional vision and general health rating in an elderly eye patient population in London, Ontario.
The Quality Of Life Of Patients With Eye Diseases, 2022 The University of Western Ontario
The Quality Of Life Of Patients With Eye Diseases, Brian Edward Yu
Electronic Thesis and Dissertation Repository
Background: Health-related Quality of Life (HRQoL) values determined using direct elicitation methods and generic preference-based measures are important for economic evaluations of healthcare interventions. The ophthalmology clientele is vulnerable to psychological stressors in the context of the coronavirus disease 2019 (COVID-19) pandemic.
Objectives: To systematically identify and summarize the quality of life (QoL) of eye disease patients in general in North America and seniors with eye diseases during the COVID-19 pandemic.
Methods: A systematic review identified North American studies that quantified HRQoL of eye disease patients. A cross-sectional study was conducted among seniors with eye diseases and backwards stepwise regression …
Effects Of Dietary Ω-3 Polyunsaturated Fatty Acids (N-3 Pufa) In Light Sensitivity Of Retinas Of Mice Models To Prevent Retinal Damage, 2022 University of Tennessee Health Science Center
Effects Of Dietary Ω-3 Polyunsaturated Fatty Acids (N-3 Pufa) In Light Sensitivity Of Retinas Of Mice Models To Prevent Retinal Damage, Aaron Eugene Rice
Longitudinal Scholar's Project
Light-induced retinal degeneration (LIRD) causes photoreceptor cell death in albino mice after exposure to high intensity light for a set period of time (6-24 hours). This causes retinal photoreceptor cell death through apoptosis. From several previous studies, Dr. Mandal’s lab concluded that de novo biosynthesis of ceramide mediates photoreceptor cell death in a LIRD model. Previous studies in Dr. Mandal’s lab has shown that mouse models with higher endogenous ω-3 Polyunsaturated Fatty Acids (n-3 PUFA) generates less ceramide upon neuronal injury and prevent neurodegeneration (Mol Neurobio 2021). There are currently not many available effective therapies for retinal degeneration in humans …
Barriers To Care For Poststroke Visual Deficits In Alberta, Canada, 2022 Alberta Health Services, Canada
Barriers To Care For Poststroke Visual Deficits In Alberta, Canada, Kiran Pohar Manhas, Karim Damji, Katelyn Brehon, Jennis Jiang, Peter Faris, Fiona Costello
Department of Ophthalmology
Poststroke visual impairment (VI) negatively affects rehabilitation potential and quality of life for stroke survivors. In this cross-sectional observational study, stroke survivors and providers were surveyed to quantify perspectives regarding care for poststroke VI in Alberta, Canada (n = 46 survivors; n = 87 providers). Few patients (35%) felt prepared to cope with VI at the time of discharge from acute stroke and inpatient rehabilitation settings. Less than 25% of stroke survivors, and
Eye Care Protocol In Critically Ill Pediatric Patients On Neuromuscular Blockage, 2022 University of Missouri-St. Louis
Eye Care Protocol In Critically Ill Pediatric Patients On Neuromuscular Blockage, Jinnie Tkach
Problem: Patients admitted to the pediatric intensive care unit (PICU) are at increased risk for the development of ocular surface disease (OSD) due to impaired ocular mechanisms while intubated, sedated, and on continuous neuromuscular blockade. The purpose of this project is to prevent OSD and vision impairments by increasing the frequency of eye care in accordance with a PICU eye care protocol.
Methods: An observational descriptive study was conducted utilizing retrospective and prospective chart review. Comparisons were drawn between the 2021 pre intervention group and the 2022 post intervention group regarding the impact of linking lubricating eye ointment orders …
Charles Bonnet Syndrome: A Case Report, 2022 Rowan University
Charles Bonnet Syndrome: A Case Report, Christian Scouarnec, Martin M. Forsberg
Stratford Campus Research Day
Charles Bonnet syndrome (CBS) involves nonthreatening hallucinations in patients who have no neurological and no psychological abnormalities but with significant visual impairment secondary to ocular disease, such as macular degeneration, cataracts and diabetic retinopathy. When a patient loses vision, their visual system doesn’t process new images. Without data coming through the eyes, the brain fills the void and makes up images or recalls stored images for you to see and this is what causes the hallucinations in CBS.
Many physicians are unaware of CBS and its prevalence, and with proper detection, physicians can help treat their patients with a frequently …
Cannabinoids And Retinal Fibrotic Disorders., 2022 University of Louisville
Cannabinoids And Retinal Fibrotic Disorders., Lucy June Sloan
Electronic Theses and Dissertations
Retinal fibrosis is detrimental to vision. Retinal pigment epithelial (RPE) cells contribute to several retinal fibrotic diseases. Upon exposure to TGF-β, a key fibrotic cytokine, RPE cells trans-differentiate to myofibroblasts marked by the integration of α-SMA fibers into F-actin stress fibers, which confer strong contractility. Myofibroblasts produce and contract the collagen-rich fibrotic scar and disrupt retinal architecture. In this study, we investigated the in vitro effects of the putative endocannabinoid compound N-oleoyl dopamine (OLDA) on TGF-β2 induced porcine RPE cell contraction and α-SMA expression. Using an in vitro collagen matrix contraction assay, we found that OLDA inhibited TGF-β2 induced contraction …
Spectroscopic Measurements Of Meibum Compositional, Structural, And Functional Relationships To Elucidate The Role Of Meibum In Dry Eye., Anthony Chigozie Ewurum
Electronic Theses and Dissertations
The major aim of my dissertation was to investigate the etiology of dry eye disease which affects about 7 million people in the United States, causing symptoms that can lead to visual disturbance. Correlation between dry eye and an abnormal lipid layer of the tear film has been found. Tear film lipids originate mostly from the meibomian glands. Cholesteryl ester (CE) and Wax ester (WE) lipids make up most of the human meibum lipidome and the CE/WE ratio has been shown to decrease in patients with meibomian gland dysfunction. Model studies using synthetic CE and WE, although providing some insight, …
Anti-Retinal Igg Antibodies In Patients With Early And Advanced Type 2 Macular Telangiectasia, 2022 Edith Cowan University
Anti-Retinal Igg Antibodies In Patients With Early And Advanced Type 2 Macular Telangiectasia, Samuel Mclenachan, Chandrakumar Balaratnasingam, Rachael C. Heath Jeffery, Shang Chih Chen, Dan Zhang, Geoffrey Chan, Rosa Dolz-Marco, Tommaso Bacci, Johnny Lo, Steven Wiffen, Lawrence A. Yannuzzi, Fred K. Chen
Research outputs 2022 to 2026
Type 2 idiopathic macular telangiectasia (MacTel-2) is a progressive adult-onset macular disease associated with bilateral perifoveal vascular changes, Muller cell degeneration and increased blood-retinal barrier permeability. The pathophysiological mechanisms of MacTel-2 remain unclear, however it was previously reported that anti-retinal antibodies in MacTel-2 patients are a significant feature of the disease. In this study, we aimed to compare the prevalence of anti-retinal antibodies in patients MacTel-2, healthy controls and patients with other retinal diseases. MacTel-2 patients diagnosed with multimodal imaging were enrolled and their disease severities were graded using spectral-domain optical coherence tomography. For comparison, patients with age-related macular degeneration …
Crispr/Cas9 Genome Editing: Future Treatment Of Duane Retraction Syndrome, 2022 Faculty of Military Pharmacy, Indonesia Defense University, Bogor, West Java, Indonesia
Crispr/Cas9 Genome Editing: Future Treatment Of Duane Retraction Syndrome, Muhammad Raihan Zulfikar, Editha Renesteen, Bantari W.K. Wardhani
Pharmaceutical Sciences and Research
Duane Retraction Syndrome (DRS) is characterized by limited eye movement. One of its causes is a mutation in the CHN1, MAFB, or SALL4 gene. Nowadays, the treatment for DRS is limited to glasses, occlusion, and surgery. However, this treatment has not been able to cure the disease’s hereditary issue. Another strategy to be considered for the treatment is CRISPR/Cas9, a tool for performing gene editing with a wide range of applications, including treating genetic diseases. We made sgRNA as a first step in using CRISPR/Cas9 as a treatment for DRS in silico using the CCTop website. By computing sgRNA, conducting …
Interventions To Improve Adherence To Recommended Diabetic Retinopathy Screening In Adult Patients With Diabetes Mellitus: A Scoping Review, 2022 University of Tennessee Health Science Center
Interventions To Improve Adherence To Recommended Diabetic Retinopathy Screening In Adult Patients With Diabetes Mellitus: A Scoping Review, Clare Anderson Bsn, Rn, Dnp, Fnp, Sarah May Bsn, Rn, Dnp, Fnp, Diana Dedmon Dnp, Aprn, Fnp-Bc
Doctor of Nursing Practice Projects
Purpose/Background Diabetic retinopathy (DR) is the leading cause of blindness in adults. Current guidelines recommend that all patients with type 2 diabetes mellitus (T2DM) have a DR screening (DRS) upon diagnosis of T2DM and then annually, but the adherence rate is only approximately 60%. This scoping review aims to evaluate the effectiveness of primary care providers (PCPs) employing strategies to increase compliance with annual DRS among adult patients with T2DM.
Methods Between September 2021 and January 2022, a literature review was performed to collect studies evaluating interventions to increase adherence to DRS. Individual searches of PubMed, SCOPUS, and CINAHL were …
Interpersonal Communication In Eye Care: An Analysis Of Potential Impacts On Cataract Surgery Candidates’ Expectations And Behaviors, Amy Hellem, Sara Labelle, Cynthia Matossian, Paul Karpecki
Communication Faculty Articles and Research
Purpose: To identify cataract surgery candidates’ knowledge, beliefs, desires and emotions as they relate to cataract surgery generally as well as to their behavioral intent to adhere to a doctor-recommended pre-surgical ocular surface prep routine designed to improve refractive outcomes and prevent surgical complications.
Methods: This national, noninterventional, cross-sectional, mixed methods survey included 278 US adults ages 65 and older with no history of cataract surgery in either eye.
Results: Only 20% of participants said they want to have cataract surgery, and even fewer (8%) said they wish they could have cataract surgery right away. Fear was the predominant emotion …
Diagnosis Of Polypoidal Choroidal Vasculopathy From Fluorescein Angiography Using Deep Learning, 2022 National Chung Cheng University
Diagnosis Of Polypoidal Choroidal Vasculopathy From Fluorescein Angiography Using Deep Learning, Yu-Yeh Tsai, Wei-Yang Ling, Shih-Jen Chen, Paisan Ruamviboonsuk, Cheng-Ho King, Chia-Ling Tsai
Publications and Research
Purpose: To differentiate polypoidal choroidal vasculopathy (PCV) from choroidal neovascularization (CNV) and to determine the extent of PCV from fluorescein angiography (FA) using attention-based deep learning networks.
Methods: We build two deep learning networks for diagnosis of PCV using FA, one for detection and one for segmentation. Attention-gated convolutional neural network (AG-CNN) differentiates PCV from other types of wet age-related macular degeneration. Gradient-weighted class activation map (Grad-CAM) is generated to highlight important regions in the image for making the prediction, which offers explainability of the network. Attention-gated recurrent neural network (AG-PCVNet) for spatiotemporal prediction is applied for segmentation …
Glaucoma Alters The Morphology Of Mouse Melanopsin-Containing Retinal Ganglion Cells, 2022 The University of Akron
Glaucoma Alters The Morphology Of Mouse Melanopsin-Containing Retinal Ganglion Cells, Kristin Keenan
Williams Honors College, Honors Research Projects
Melanopsin ganglion cells are intrinsically photosensitive ganglion cells in the mammalian retina. These cells mediate aspects of non-image forming vision to help regular circadian rhythm. Glaucoma is an eye disease involving an increase in intraocular pressure that has been linked to irregular circadian rhythm. This project will investigate the impact glaucoma has on these melanopsin ganglion cells at different pathological timepoints. This will be performed by using dissection, immunohistochemistry, and computer imaging methods to visualize, trace, and measure the cells’ morphologies in both control and glaucomatous retinas at different timepoints of disease to analyze if glaucoma has a significant effect …