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Search For Palladin, An Actin-Associated Protein, In Pig Retinal Pigmented Epithelium And Its Role In Epithelial-Mesenchymal Transition, Katrina Powell 2021 Bellarmine University

Search For Palladin, An Actin-Associated Protein, In Pig Retinal Pigmented Epithelium And Its Role In Epithelial-Mesenchymal Transition, Katrina Powell

Undergraduate Theses

This study investigates the expression of Palladin, a phosphoprotein product of the PALLD gene, in the retinal pigmented epithelium (RPE). Palladin is an actin cross-linking protein and plays a role in cell adhesion and motility. Published reports have demonstrated that a down regulation of Palladin in colon cancer cells results in a reorganization of the actin cytoskeleton, causing the cells to lose their typical shape, become proliferative and migratory. This process is otherwise known as epithelial-mesenchymal transition (EMT). A similar EMT phenomenon is observed when the RPE is exposed to the vitreous humor in patients with proliferative vitreoretinopathy (PVR). In ...


Pathogenesis Of Dry Eye In Graft Versus Host Disease (Gvhd): Role Of Ocular Mucins And Conjunctival Fibrosis, Kiumars Shamloo 2021 Chapman University

Pathogenesis Of Dry Eye In Graft Versus Host Disease (Gvhd): Role Of Ocular Mucins And Conjunctival Fibrosis, Kiumars Shamloo

Pharmaceutical Sciences (PhD) Dissertations

Allogenic hematopoietic stem cell transplantation is a procedure that offers a possible cure for hematologic cancers and other hematologic disorders. Unfortunately, despite the increasing survival rate of patients, the quality of their life is adversely affected by the allogeneic bone marrow transplantation’s major side effect i.e Graft vs. Host Disease (GVHD). GVHD is a complex, multi-organ disease resulting from an immunological attack by donor engrafted immune cells to host organs, including the eye surface. Mostly based on the time of disease onset after transplantation, GVHD is divided into the acute and chronic phase. The eyes may be involved ...


Categorization Of Marketed Artificial Tear Formulations Based On Their Ingredients: A Rational Approach For Their Use, Avani Kathuria, Kiumars Shamloo, Vishal Jhanji, Ajay Sharma 2021 Chapman University

Categorization Of Marketed Artificial Tear Formulations Based On Their Ingredients: A Rational Approach For Their Use, Avani Kathuria, Kiumars Shamloo, Vishal Jhanji, Ajay Sharma

Pharmacy Faculty Articles and Research

Dry eye disease is a common ocular condition affecting millions of people worldwide. Artificial tears are the first line therapy for the management of dry eye disease. Artificial tear formulations contain a variety of active ingredients, biologically active excipients, and preservatives. Many of these formulations are also available as preservative-free. This study was conducted to inspect artificial tear formulations currently marketed in the United States for their active ingredients, biologically relevant excipients, and preservatives. The marketed artificial tears were examined at various US retail pharmacy chains and using the manufacturers’ website to compile information about active ingredients, inactive ingredients, and ...


Association Between Ambient Temperature, Particulate Air Pollution And Emergency Room Visits For Conjunctivitis, S. Khalaila, T. Coreanu, A. Vodonos, I. Kloog, A. Shtein, Lauren Colwell, V. Novack, E. Tsumi 2021 Soroka University Medical Center

Association Between Ambient Temperature, Particulate Air Pollution And Emergency Room Visits For Conjunctivitis, S. Khalaila, T. Coreanu, A. Vodonos, I. Kloog, A. Shtein, Lauren Colwell, V. Novack, E. Tsumi

Open Access Publications by UMMS Authors

BACKGROUND: Numerous studies have confirmed the association of ambient temperature and air pollution with a higher risk of morbidities, yet few have addressed their effect on the ocular system. The purpose of this study was to assess the association between temperature, air pollution, and emergency room visits for conjunctivitis.

METHODS: In this case-crossover study, the records of all emergency room visits to Soroka University Medical Center (SUMC) from 2009 to 2014 were reviewed for patients with conjunctivitis. Daily exposure to fine and coarse particulate matter and temperature were determined by a hybrid model involving satellite sensors. Mean relative humidity was ...


Stability Evaluation Of Extemporaneously Compounded Vancomycin Ophthalmic Drops: Effect Of Solvents And Storage Conditions, Christopher Ross, Basir Syed, Joanna Pak, Vishal Jhanji, Jason Yamaki, Ajay Sharma 2021 Chapman University

Stability Evaluation Of Extemporaneously Compounded Vancomycin Ophthalmic Drops: Effect Of Solvents And Storage Conditions, Christopher Ross, Basir Syed, Joanna Pak, Vishal Jhanji, Jason Yamaki, Ajay Sharma

Pharmacy Faculty Articles and Research

Vancomycin is the drug of choice for methicillin-resistant Staphylococcus aureus keratitis and other ocular infections. Vancomycin ophthalmic drops are not commercially available and require compounding. The present study was designed to investigate the stability of vancomycin ophthalmic drops in normal saline, phosphate-buffered saline (PBS), and balanced salt solution (BSS) while stored at room temperature or under refrigeration. Vancomycin ophthalmic drops (50 mg/mL) were aseptically prepared from commercially available intravenous powder using PBS, BSS, and saline. Solutions were stored at room temperature and in a refrigerator for 28 days. The vancomycin stability was tested by a microbiology assay and high-performance ...


Post-Operative Day 1 Versus Day 0 Follow-Up For Uncomplicated Cataract Surgeries: A Comparison Of Post-Operative Outcomes And Managements, Harsh Parekh BS, Shibandri Das MD, Vaama Patel MD, Ryan Freedman MD, Sabba Mansoor BS, Amanda Ismail MD, Faisal Ridha Al-Timimi MD 2021 Wayne State University School of Medicine

Post-Operative Day 1 Versus Day 0 Follow-Up For Uncomplicated Cataract Surgeries: A Comparison Of Post-Operative Outcomes And Managements, Harsh Parekh Bs, Shibandri Das Md, Vaama Patel Md, Ryan Freedman Md, Sabba Mansoor Bs, Amanda Ismail Md, Faisal Ridha Al-Timimi Md

Medical Student Research Symposium

Purpose: To compare the postoperative outcomes and management of uncomplicated cataract surgery (CEIOL) patients seen on post-operative day zero (POD 0) versus post-operative day one (POD 1).

Methods: A retrospective chart review of 533 patients who had CEIOL at the Kresge Eye Institute from December 2017 to September 2019 was performed. Visual acuity (VA) and intraocular pressure (IOP) were collected from the pre-operative visit, and the first and second post-operative day visits. In addition, changes in management were recorded from the first post-operative day visit. Patients were excluded if they had a complex cataract procedure, had combined glaucoma filtering surgery ...


Rpgr Isoform Imbalance Causes Ciliary Defects Due To Exon Orf15 Mutations In X-Linked Retinitis Pigmentosa (Xlrp), Laura Moreno-Leon, Emma L. West, Michelle O'Hara-Wright, Linjing Li, Rohini Nair, Jie He, Manisha Anand, Bhubanananda Sahu, Venkat Ramana Murthy Chavali, Alexander J. Smith, Robin R. Ali, Samuel G. Jacobson, Artur V. Cideciyan, Hemant Khanna 2021 University of Massachusetts Medical School

Rpgr Isoform Imbalance Causes Ciliary Defects Due To Exon Orf15 Mutations In X-Linked Retinitis Pigmentosa (Xlrp), Laura Moreno-Leon, Emma L. West, Michelle O'Hara-Wright, Linjing Li, Rohini Nair, Jie He, Manisha Anand, Bhubanananda Sahu, Venkat Ramana Murthy Chavali, Alexander J. Smith, Robin R. Ali, Samuel G. Jacobson, Artur V. Cideciyan, Hemant Khanna

Open Access Publications by UMMS Authors

Mutations in retinitis pigmentosa GTPase regulator (RPGR) cause severe retinal ciliopathy, X-linked retinitis pigmentosa. Although two major alternatively spliced isoforms, RPGRex1-19 and RPGRORF15, are expressed, the relative importance of these isoforms in disease pathogenesis is unclear. Here, we analyzed fibroblast samples from eight patients and found that all of them form longer cilia than normal controls, albeit to different degrees. Although all mutant RPGRORF15 messenger RNAs (mRNAs) are unstable, their steady-state levels were similar or higher than those in the control cells, suggesting there may be increased transcription. Three of the fibroblasts that had higher levels of mutant RPGRORF15 mRNA ...


Young Woman With Blurry Vision, Christopher DiTullio, Gayle Galletta 2021 University of Massachusetts Medical School

Young Woman With Blurry Vision, Christopher Ditullio, Gayle Galletta

Open Access Publications by UMMS Authors

A 26‐year‐old female with no significant past medical history presented to the emergency department with 1‐week history of blurred vision and difficulty with depth perception, most pronounced when looking to the left or right while driving. She is a teacher and remarked that her students noted her eyes were “moving funny” when she looked in either direction. On examination, when the patient gazed to the right, extraocular movements showed an inability to adduct the left eye past the midline and delayed abduction of the right eye. Additionally, with gaze to the left, extraocular movements showed inability to ...


A Case Report Discussing An Uncommon Peripheral Exudative Hemorrhagic Chorioretinopathy, Marlon J. Demeritt, Beata I. Lewandowska 2021 Nova Southeastern University

A Case Report Discussing An Uncommon Peripheral Exudative Hemorrhagic Chorioretinopathy, Marlon J. Demeritt, Beata I. Lewandowska

Internet Journal of Allied Health Sciences and Practice

Purpose: The purpose of this case report is to discuss an uncommon, unique hemorrhagic chorioretinopathy. Method: A 79-year-old-white female presented to clinic with complaints of difficulty reading at close distances and seeing faces at far distances in both eyes. An 85-year old white female presented with no visual complaints but stated redness in the nasal corner of her right eye. This is a case report of two patients that presented with geographic atrophy of the macula as well as midperipheral RPE alterations in both eyes, which resembled intraretinal hemorrhages. Results: The ocular findings associated with peripheral exudative hemorrhagic chorioretinopathy may ...


The Role Of Simulators In Improving Vitreoretinal Surgery Training - A Systematic Review, Taha Muneer Ahmed, Rehman Siddiqui 2021 Aga Khan University

The Role Of Simulators In Improving Vitreoretinal Surgery Training - A Systematic Review, Taha Muneer Ahmed, Rehman Siddiqui

Medical College Documents

Objective: To conduct an appraisal of current evidence regarding the effectiveness of EyeSi®-based training of vitreoretinal surgery.
Methods: The systematic review was conducted in July 2020, and comprised literature search on Cochrane Library, PubMed and Embase for articles regarding simulation training in vitreoretinal surgery. The shortlisted articles were subjected to qualitative analysis. Existing evidence was assessed, and predictions on how outcomes may be applied to improve vitreoretinal surgery training were made. The risk of bias of each study was calculated in line with the guidelines of the Cochrane Handbook.
Results: Of the 124 articles identified, 7(5.6%) were ...


Treatment Of Orbital Lesions Using Cyberknife Stereotactic Radiosurgery, Emily Morahan 2021 Misericordia University

Treatment Of Orbital Lesions Using Cyberknife Stereotactic Radiosurgery, Emily Morahan

Student Research Poster Presentations 2021

The purpose of the research done was to evaluate the use of CyberKnife Stereotactic Radiosurgery (SRS) for treating orbital lesions. Efficacy and tolerability of such treatment was analyzed with data drawn from multiple sources, regarding dose and fractionation, quality of life following treatment(s) and prognosis. CyberKnife SRS is the newest, most advanced model of radiation delivery systems, featuring a robotic arm capable of manipulating the linear accelerator into thousands of unique angles. The addition of new angles allows for a more precise concentration of radiation delivered to the lesions. In the case of optic lesions, it is crucial to ...


Causes Of Color Blindness: Function And Failure Of The Genes That Detect Color, Dylan Taylor 2020 Liberty University

Causes Of Color Blindness: Function And Failure Of The Genes That Detect Color, Dylan Taylor

Senior Honors Theses

Color blindness affects nearly 10% of the entire population, with multiple types of color blindness from various genetic mutations. In the following sections, the nature of light and how the human eye perceives light will be discussed. Afterward, the major forms of color blindness and their genetic causes will be considered. Once these genetic causes have been established, the current method for diagnosing color blindness will be investigated, followed by a discussion of the current treatments available to those with color blindness. Finally, a brief discussion will address possible future work for color blindness with the hope of finding better ...


Rare And Common Genetic Variants, Smoking, And Body Mass Index: Progression And Earlier Age Of Developing Advanced Age-Related Macular Degeneration, Johanna M. Seddon, Rafael Widjajahakim, Bernard Rosner 2020 University of Massachusetts Medical School

Rare And Common Genetic Variants, Smoking, And Body Mass Index: Progression And Earlier Age Of Developing Advanced Age-Related Macular Degeneration, Johanna M. Seddon, Rafael Widjajahakim, Bernard Rosner

Open Access Publications by UMMS Authors

Purpose: To determine behavioral and genetic factors associated with incidence and age of progression to advanced age-related macular degeneration (AMD), geographic atrophy (GA), and neovascular disease (NV), and to quantify these effects.

Methods: Longitudinal analyses were conducted among 5421 eyes with nonadvanced AMD at baseline in 2976 participants in the Age-Related Eye Disease Study (mean age of 68.8 (+/-5.0), 56.1% female). Progression was confirmed based on two consecutive visits on the AMD severity scale. Separate analyses for progression and age of progression were performed. All analyses adjusted for correlation between eyes, demographic and behavioral covariates, baseline severity ...


Assessing Disease Severity Of Diabetic Retinopathy Using Novel Graphical Interpretation Of Flicker Electroretinogram, Anjalee Choudhury, Jonas Moses, Victor Gonzalez 2020 The University of Texas Rio Grande Valley

Assessing Disease Severity Of Diabetic Retinopathy Using Novel Graphical Interpretation Of Flicker Electroretinogram, Anjalee Choudhury, Jonas Moses, Victor Gonzalez

MEDI 9331 Scholarly Activities Clinical Years

Purpose: To assess the clinical value of reporting full-field electroretinogram (eg, flicker ERG) findings graphically to determine the severity of diabetic retinopathy (DR) within an office-based setting.

Methods: Patients with type 2 diabetes mellitus were included and classified into varying degrees of DR based on presence and severity. Flicker ERG responses were recorded and compared between groups.

Results: Between the varying disease stages, significant differences in the mean magnitude and phase values were found. There was also a significant difference between the proportions of the magnitude and phase color-coded frequencies between groups of severity and threat to vision.

Conclusion: Magnitude ...


Factores Asociados A Retinopatía En Diabetes Mellitus, Angie Nicole Peñuela Suárez, Fabio Andrés Manrique, Paula Daniel Pérez Espinel, Diana Valeria Rey Rodríguez, María Camila Sotomonte Flórez 2020 Universidad El Bosque

Factores Asociados A Retinopatía En Diabetes Mellitus, Angie Nicole Peñuela Suárez, Fabio Andrés Manrique, Paula Daniel Pérez Espinel, Diana Valeria Rey Rodríguez, María Camila Sotomonte Flórez

Ciencia y Tecnología para la Salud Visual y Ocular

El propósito de esta investigación fue identificar, a través de la búsqueda de la literatura, factores asociados que afectan a la población que padece retinopatía diabética (RD). Para esto, se realizó una búsqueda electrónica de artículos científicos en las bases de datos Medline (PubMed) y LILACS, utilizando descriptores DeCS, donde de incluyeron palabras claves como factores de riesgo, diabetes y retinopatía. Como resultado, se identificaron 9 estudios, en donde los factores asociados a RD en la población con diabetes mellitus fue dislipidemia, control glucémico, área rural, hipertensión arterial, duración de la diabetes, tabaquismo, obesidad, índice de masa corporal (IMC), hemoglobina ...


Rad21 Is Involved In Corneal Stroma Development By Regulating Neural Crest Migration, Bi Ning Zhang, Yu Liu, Qichen Yang, Pui Ying Leung, Chengdong Wang, Thomas Chi Wong Bun, Clement C. Tham, Sun On Chan, Chi Pui Pang, Li Jia Chen, Job Dekker, Hui Zhao, Wai Kit Chu 2020 The Chinese University of Hong Kong

Rad21 Is Involved In Corneal Stroma Development By Regulating Neural Crest Migration, Bi Ning Zhang, Yu Liu, Qichen Yang, Pui Ying Leung, Chengdong Wang, Thomas Chi Wong Bun, Clement C. Tham, Sun On Chan, Chi Pui Pang, Li Jia Chen, Job Dekker, Hui Zhao, Wai Kit Chu

Open Access Publications by UMMS Authors

Previously, we identified RAD21(R450C) from a peripheral sclerocornea pedigree. Injection of this rad21 variant mRNA into Xenopus laevis embryos disrupted the organization of corneal stroma fibrils. To understand the mechanisms of RAD21-mediated corneal stroma defects, gene expression and chromosome conformation analysis were performed using cells from family members affected by peripheral sclerocornea. Both gene expression and chromosome conformation of cell adhesion genes were affected in cells carrying the heterozygous rad21 variant. Since cell migration is essential in early embryonic development and sclerocornea is a congenital disease, we studied neural crest migration during cornea development in X. laevis embryos. In ...


Metachronous Eyelid Basal Cell Carcinoma On Opposite Eye And Lid: A Case Report, Danielle C. Kalberer OD, FAAO, Matthew A. DelMauro MD 2020 Northport Veterans Affairs Medical Center

Metachronous Eyelid Basal Cell Carcinoma On Opposite Eye And Lid: A Case Report, Danielle C. Kalberer Od, Faao, Matthew A. Delmauro Md

Optometric Clinical Practice

Background: Basal cell carcinoma (BCC) is the most common eyelid malignancy, accounting for approximately 90% of malignant eyelid lesions.1 Despite its high occurrence rates, it is frequently misdiagnosed as one of the benign “lumps and bumps” that can be present on the eyelid. In the present case, a patient with a past BCC on the right upper eyelid presented with a left lower eyelid lesion which persisted for months before the patient sought evaluation by an eyecare provider. This benign-looking lash-line lesion was the only external sign of the malignancy found on the deep surface of the eyelid and ...


Manejo De Detrito Con Hápticas Tóricas En Un Lente Escleral, Para Un Paciente Con Queratotomía Radial, Manuel Sánchez-Pérez, Sandra Paola Partido-Echeverría 2020 Hospital General de México

Manejo De Detrito Con Hápticas Tóricas En Un Lente Escleral, Para Un Paciente Con Queratotomía Radial, Manuel Sánchez-Pérez, Sandra Paola Partido-Echeverría

Ciencia y Tecnología para la Salud Visual y Ocular

En la actualidad, una de las mejores maneras para rehabilitar visualmente a pacientes con importantes irregularidades corneales es con los lentes de contacto esclerales. No obstante, con ellos también se han presentado diversas complicaciones como la presencia de detrito entre el lente y la córnea. En el presente artículo se presenta un caso en el cual se dio este fenómeno y a través de ese se describirá su manejo mediante la modificación de la zona háptica, pruebas optométricas realizadas y el respectivo seguimiento. Se presenta el caso de una mujer de 53 años, posoperada de queratotomía radial por miopía alta ...


Effect Of High Glucose On Ocular Surface Epithelial Cell Barrier And Tight Junction Proteins, Saleh M. Alfuraih, Ashley Barbarino, Christopher Ross, Kiumars Shamloo, Vishal Jhanji, Miao Zhang, Ajay Sharma 2020 Chapman University

Effect Of High Glucose On Ocular Surface Epithelial Cell Barrier And Tight Junction Proteins, Saleh M. Alfuraih, Ashley Barbarino, Christopher Ross, Kiumars Shamloo, Vishal Jhanji, Miao Zhang, Ajay Sharma

Pharmacy Faculty Articles and Research

PURPOSE. Patients with diabetes mellitus are reported to have ocular surface defects, impaired ocular surface barrier function, and a higher incidence of corneal and conjunctival infections. Tight junctions are critical for ocular surface barrier function. The present study was designed to investigate the effect of high glucose exposure on human corneal and conjunctival epithelial cell barrier function and tight junction proteins.

METHODS. Human corneal and conjunctival epithelial cells were exposed to 15 mM and 30 mM glucose for 24 and 72 hours. The barrier function was measured using transepithelial electrical resistance (TEER). The cell migration was quantified using scratch assay ...


Manifestaciones Oculares Del Covid-19, Nancy Piedad Molina-Montoya 2020 Universidad de La Salle, Bogotá

Manifestaciones Oculares Del Covid-19, Nancy Piedad Molina-Montoya

Ciencia y Tecnología para la Salud Visual y Ocular

No abstract provided.


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