Evaluation Of Antifungal Efficacy In The Treatment Of Candida Auris Bloodstream Infections, 2023 Roseman University of Health Sciences
Evaluation Of Antifungal Efficacy In The Treatment Of Candida Auris Bloodstream Infections, Monique Busacay, Kaylee Putney, Rebecca Jayakumar
Annual Research Symposium
No abstract provided.
Clinical Effects Of Lactobacillus Reuteri Probiotic In The Treatment Of Chronic Periodontitis: A Systematic Review Of Randomized Controlled Trials, 2023 Roseman University of Health Sciences
Clinical Effects Of Lactobacillus Reuteri Probiotic In The Treatment Of Chronic Periodontitis: A Systematic Review Of Randomized Controlled Trials, Josephine Ram, Shilpa Bhandi, Kamran H. Awan, Frank Licari, Shankargouda Patil
Annual Research Symposium
No abstract provided.
Performance Of A Sars-Cov-2 Rt-Pcr Assay With Non-Traditional Specimen Types, 2023 University of Louisville
Performance Of A Sars-Cov-2 Rt-Pcr Assay With Non-Traditional Specimen Types, Subathra Marimuthu, Holly Aliesky, Heather Ness, Daniya Sheikh, Sathya Rashmit, Dawn Balcom, Leslie A. Wolf
The University of Louisville Journal of Respiratory Infections
During the first two years of the coronavirus disease 2019 (COVID-19) pandemic, nasopharyngeal (NP) specimens were the gold standard for clinical diagnostic testing. As information about the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the pandemic continued to be shared, it was clear that the virus could be detected in other specimen types during an active infection. The University of Louisville Infectious Diseases Laboratory accepted non-traditional specimen types, most without a paired, positive NP result, for research purposes only to support local epidemiology efforts. A real-time reverse transcription-polymerase chain reaction (RT-PCR) assay originally validated for NP specimens was used …
What? Now A Respiratory Syncytial Virus Epidemic, 2023 University of Louisville
What? Now A Respiratory Syncytial Virus Epidemic, Aya Allam, Steven B Lippmann
The University of Louisville Journal of Respiratory Infections
No abstract provided.
Chlamydia Trachomatis Subverts Alpha-Actinins To Stabilize Its Inclusion, 2023 Thomas Jefferson University
Chlamydia Trachomatis Subverts Alpha-Actinins To Stabilize Its Inclusion, A. Haines, J. Wesolowski, F. Paumet
Department of Microbiology and Immunology Faculty Papers
Chlamydia trachomatis is the leading cause of sexually transmitted bacterial disease and a global health burden. As an obligate intracellular pathogen, Chlamydia has evolved many strategies to manipulate its host and establish its intracellular niche called the inclusion. C. trachomatis reorganizes the host actin cytoskeleton to form scaffolds around the inclusion and reinforce the growing inclusion membrane. To control the kinetics and formation of actin scaffolds, Chlamydia expresses the effector InaC/CT813, which activates the host GTPase RhoA. Here, we have discovered that InaC stabilizes actin scaffolds through the host actin cross-linking proteins α-actinins 1 and 4. We demonstrate that α-actinins …
Impact Of Enteropathogens On Faltering Growth In A Resource-Limited Setting, 2023 Aga Khan University
Impact Of Enteropathogens On Faltering Growth In A Resource-Limited Setting, Furqan Kabir, Junaid Iqbal, Zehra Jamil, Najeeha Talat Iqbal, Fatima Aziz, Adil Kalam, Sahrish Muneer, Aneeta Hotwani, Sheraz Ahmed, Fayyaz Umrani, Sana Syed, Kamran Sadiq, Syed Asad Ali
Department of Paediatrics and Child Health
Introduction: Environmental enteropathy is an important contributor to childhood malnutrition in the developing world. Chronic exposure to fecal pathogens leads to alteration in intestinal structure and function, resulting in impaired gut immune function, malabsorption, and growth faltering leading to environmental enteropathy.
Methods: A community-based intervention study was carried out on children till 24 months of age in Matiari district, Pakistan. Blood and fecal specimens were collected from the enrolled children aged 3-6 and 9 months. A real-time PCR-based TaqMan array card (TAC) was used to detect enteropathogens.
Results: Giardia, Campylobacter spp., enteroaggregative Escherichia coli (EAEC), Enteropathogenic Escherichia coli (EPEC), …
Unique Presentation Of Cerebritis: A Case Report, 2023 HCA Healthcare
Unique Presentation Of Cerebritis: A Case Report, Wajahat Dawood, Kevin Jiang, Bryan Kharbanda
Gulf Coast Division Research Day 2023
No abstract provided.
Clostridium Septicum Bacteremia As The Presenting Sign Of Colon Cancer, 2023 HCA Healthcare
Clostridium Septicum Bacteremia As The Presenting Sign Of Colon Cancer, Andrew Abraham, Sripal Padam
North Florida Division Research Day 2023
No abstract provided.
Does The Cdc Covid-19 Exposure Assessment Criteria For Healthcare Personnel Work In A Healthcare Setting In Pakistan?, 2023 Aga Khan University
Does The Cdc Covid-19 Exposure Assessment Criteria For Healthcare Personnel Work In A Healthcare Setting In Pakistan?, Imran Hassan, Unab Khan, Shehreen Ali, Asif Hakim, Asad Ali
Department of Family Medicine
Objective: To evaluate the real-world performance of the CDC's "Interim US guidance for risk assessment and work restriction for healthcare personnel with exposure to COVID-19" at a private healthcare system in Pakistan.
Study design: Retrospective observational study.
Place and duration of study: The Aga khan University Hospital, Karachi, and its associated healthcare facilities in all four provinces of Pakistan, from February to September 2020.
Methodology: Healthcare personnel (HCPs) assessed and tested for exposures to COVID-19 were included in the study. An exposure category was assigned to each HCP presenting with exposure to COVID-19 based on the CDC criteria. Percentage positivity …
A Rare Case Of Right Atrial Appendage Mass In Patient With Recurrent Methicillin-Resistant Staphylococcus Aureus Bacteremia, 2023 HCA Healthcare
A Rare Case Of Right Atrial Appendage Mass In Patient With Recurrent Methicillin-Resistant Staphylococcus Aureus Bacteremia, Vivek Nadipalli, Ahmed Mahmood, Thomas Alexander
Gulf Coast Division Research Day 2023
No abstract provided.
Cryptogenic Liver Abscess Caused By Actinomyces Meyeri, 2023 HCA Healthcare
Cryptogenic Liver Abscess Caused By Actinomyces Meyeri, Thomas Walter, Simona Oprea, Greg Hicks
Continental, MidAmerica, & Mountain Divisions Research Day 2023
No abstract provided.
Clinical Utility Of Neutrophil To Lymphocyte Ratio In Sickle Cell Disease With Vaso-Occlusive Crisis, 2023 Hematology & Oncology, Internal Medicine, Texas Tech University
Clinical Utility Of Neutrophil To Lymphocyte Ratio In Sickle Cell Disease With Vaso-Occlusive Crisis, Satish Maharaj, Simone Chang
Hematology/Oncology and Stem Cell Therapy
Background and objectives: The neutrophil-to-lymphocyte ratio represents a universally accessible value that correlates with inflammation and prognosis in several disease states; however, the role of this biomarker in sickle cell disease remains poorly explored. Hence, the objective of the present study was to determine its potential clinical utility in patients with sickle cell disease.
Patients: Herein, we retrospectively reviewed 143 patients with sickle cell disease who presented to the emergency department with fever and painful vaso-occlusive crisis.
Results: The examined cohort had a prevalence of 11% confirmed bacterial infection, with approximately two-thirds reporting the use of hydroxyurea. The neutrophil-to-lymphocyte ratio …
Combatting Bacterial Infections: The Efficacy Of Poly-Gamma-Glutamic Acid On The Prevention Of Nasopharyngeal Infections Among Individuals With Cleft Lip And Palate, 2023 Scripps College
Combatting Bacterial Infections: The Efficacy Of Poly-Gamma-Glutamic Acid On The Prevention Of Nasopharyngeal Infections Among Individuals With Cleft Lip And Palate, Florence Pun
Scripps Senior Theses
Cleft lip and palate (CLP) is a medical condition where children are born with an unfused lip and palate. While surgery is required to fuse the lip and palate, there are other conditions that children with CLP face after surgeries, such as otitis media (OM), speech impediments, and difficulty breathing. Particularly, OM occurs frequently in individuals with CLP because the tensor veli palatini muscles cannot open the Eustachian tube frequently and ventilate the middle ear properly, even after surgery. This thesis is a research proposal to evaluate whether γ-PGA can be used in nasal washes to safely prevent nasopharyngeal infections …
Case Report Of Extensive Spinal Epidural Abscess, 2023 HCA Healthcare
Case Report Of Extensive Spinal Epidural Abscess, Eric Brown, Marcus Zorovich
Far West Division Research Day 2023
No abstract provided.
Burkholderia Collagen-Like Protein 8, Bucl8, Is An Outer-Membrane Component Of A Novel Efflux Pump And Immunogenic Vaccine Candidate, 2023 West Virginia University
Burkholderia Collagen-Like Protein 8, Bucl8, Is An Outer-Membrane Component Of A Novel Efflux Pump And Immunogenic Vaccine Candidate, Megan Elizabeth Grund
Graduate Theses, Dissertations, and Problem Reports
Burkholderia spp. are Gram‐negative intrinsically resistant bacteria that are responsible for environmental and nosocomial infections of clinical and biodefense concern. Our laboratory previously identified in silico Burkholderia collagen-like protein 8 (Bucl8) in the BSL-3 pathogens Burkholderia pseudomallei and Burkholderia mallei (Figure 1). The protein sequence of Bucl8 contains tandem outer-membrane efflux protein domains (OEP) typical of efflux systems and a unique collagen-like domain (CL) consisting of a repeating sequence of Glycine-Alanine-Serine (GAS). Because efflux pumps are often a mechanism of pathogenicity and antibiotic resistance, we investigated Bucl8 further. Here, we determined that the locus of bucl8 contains genes …
Acute Colonic Perforation With Septic Shock Secondary To Disseminated Histoplasmosis In A Autologous Bone Marrow Transplant Recipient, 2023 HCA Healthcare
Acute Colonic Perforation With Septic Shock Secondary To Disseminated Histoplasmosis In A Autologous Bone Marrow Transplant Recipient, Harsimrandeep Bhatti, Srijisnu De, Enkhbileg Batbileg, Glen Friedman
Central & West Texas Research Day 2023
No abstract provided.
Burkholderia Cepacia Causing Ards In A Patient Without Cystic Fibrosis, 2023 HCA Healthcare
Burkholderia Cepacia Causing Ards In A Patient Without Cystic Fibrosis, Igbayilola Dosunmu, Shahriar Sharif, Samyukta Swaminath, Nashit Mozumder, Diego Marin
East Florida Research Day 2023
No abstract available.
Subacute Stroke Like Presentation Likely Due To Disseminated Histoplasmosis In An Immunocompromised Patient, 2023 HCA Healthcare
Subacute Stroke Like Presentation Likely Due To Disseminated Histoplasmosis In An Immunocompromised Patient, Ashley R. Diaz, Priya Mohan, Utmitha Konda, Alfonso Manotas, Issac Ichoa
East Florida Research Day 2023
Histoplasmosis capsulatum is an opportunistic fungal infection that is largely asymptomatic and found to have nonspecific signs and symptoms. It predominates in Central and North America, and is one of the leading causes of hospitalization among the fungal family. However, in the right host, such as in this case, a patient with significant immunosuppression can develop serious manifestations as it disseminates outside of the pulmonary system. The challenging element of disseminated histoplasmosis is that despite proper treatment immunocompromised patients will frequently relapse with worsening presentation. There is limited literature on subacute stroke-like presentation in a patient with chronic infection of …
Surviving The Apprehensive Methicillin-Sensitive Staphylococcus Aureus (Mssa) Bacteremia: A Case Of Bacteremia With An Undetermined Source Of Infection Leading To Suspected Cardioembolic Ischemia And Biochemical Septic Shock, Greisy D. Curbelo Sesin, Eduardo Marino-Urbino, Christopher Fontela, Melanio J. Rodriguez, Jorge A. Diaz, Shivaan C. Oomrigar, Ramon Mendoza Bello, Yoandy Rodriguez Fuentes
East Florida Research Day 2023
Introduction: This research presents a complex case of a 70-year-old male with acute metabolic encephalopathy and biochemical septic shock, later attributed to cardioembolic ischemia, resulting from Methicillin-Sensitive Staphylococcus Aureus (MSSA) bacteremia with an elusive source of infection.
Case Description: The 70-year-old patient, with a medical history of hypertension and aortic valve stenosis status post-Coronary Artery Bypass Grafting and bioprosthetic valve replacement on dual anti-platelet therapy (clopidogrel and aspirin), was admitted following an unwitnessed fall and a day of vomiting and generalized weakness. Upon arrival, the patient exhibited altered mental status, hypotension, and acidosis. Initial diagnostic workup raised suspicion of biochemical …
Why A High Titer Rheumatoid Factor And Joint Pain Should Not Automatically Translate Into A Diagnosis Of Rheumatoid Arthritis, 2023 HCA Healthcare
Why A High Titer Rheumatoid Factor And Joint Pain Should Not Automatically Translate Into A Diagnosis Of Rheumatoid Arthritis, Saba Ashraf, Julio Gonzalez-Paoli
West Florida Division Research Day 2023
No abstract provided.