Animal Carcinogenicity Studies: 2. Obstacles To Extrapolation Of Data To Humans, 2016 Animal Consultants International
Animal Carcinogenicity Studies: 2. Obstacles To Extrapolation Of Data To Humans, Andrew Knight, Jarrod Bailey, Jonathan Balcombe
Jonathan Balcombe, PhD
Due to limited human exposure data, risk classification and the consequent regulation of exposure to potential carcinogens has conventionally relied mainly upon animal tests. However, several investigations have revealed animal carcinogenicity data to be lacking in human predictivity. To investigate the reasons for this, we surveyed 160 chemicals possessing animal but not human exposure data within the US Environmental Protection Agency chemicals database, but which had received human carcinogenicity assessments by 1 January 2004. We discovered the use of a wide variety of species, with rodents predominating, and of a wide variety of routes of administration, and that there were …
What It Is To Be A Dog: A Qualitative Method For The Study Of Animals Other Than Humans, 2016 Animals and Society Institute
What It Is To Be A Dog: A Qualitative Method For The Study Of Animals Other Than Humans, Kenneth J. Shapiro
Kenneth J. Shapiro, PhD
No abstract provided.
A New Invasiveness Scale: Its Role In Reducing Animal Distress, 2016 Animals and Society Institute
A New Invasiveness Scale: Its Role In Reducing Animal Distress, Kenneth J. Shapiro, Peter B. Field
Kenneth J. Shapiro, PhD
No abstract provided.
Animal Model Research: The Apples And Oranges Quandary, 2016 Psychologists for the Ethical Treatment of Animals
Animal Model Research: The Apples And Oranges Quandary, Kenneth J. Shapiro
Kenneth J. Shapiro, PhD
In this paper, I explore the premises underlying the problem of the evaluation of animal models. I argue that the presence of similarities and differences between the model and the modelled, although historically and currently a dominant antinomy framing evaluation, is not a bottom-line consideration. What is critical is 1) whether we learn and 2) whether we improve treatment through the animal model research. Similarity between model and modelled and the closely related concept of validity are not coterminus with these critical evaluative measures. In fact, differences between the model and modelled also can provide impetus to new understanding and …
Simulating Mars: Student Projects At Mars Desert Research Station (Mdrs), 2016 Embry-Riddle Aeronautical University - Daytona Beach
Simulating Mars: Student Projects At Mars Desert Research Station (Mdrs), Ashley Hollis-Bussey, Lycourgos Manolopoulos, Marc Carofano, Hiroki Sugimoto, Cassandra Vella, John Herman
Human Factors and Applied Psychology Student Conference
No abstract provided.
Non-Essentiality Of Alr And Muri Genes In Mycobacteria, 2016 University of Nebraska - Lincoln
Non-Essentiality Of Alr And Muri Genes In Mycobacteria, Philion L. Hoff, Denise Zinniel, Raúl G. Barletta
UCARE Research Products
Amino acids are the building blocks of life. If DNA is the blueprint, amino acids are the lumber that proteins are built with. Proteins are built with left-handed, L- forms of amino acids. Bacteria have an essential cell wall component that happens to be an exception: peptidoglycan. Bacteria have enzymes called racemases that convert L- amino acid forms into right-handed, D- forms. Amino acids participate in many reactions with keto acids. Transaminases allow conversion between amino acids by transfer of an amino group.
Previous reports claimed there is no D-ala transaminase activity in mycobacteria and thus alr and murI genes …
How Nebraska’S Eastern Saline Wetland Native Plant Species Grow In Response To Restoration Methods: Application Of Different Salinity Level Groundwater, 2016 University of Nebraska-Lincoln
How Nebraska’S Eastern Saline Wetland Native Plant Species Grow In Response To Restoration Methods: Application Of Different Salinity Level Groundwater, Ellen Dolph, Keunyea Song, Amy Burgin, Trenton E. Franz
UCARE Research Products
Nebraska’s Eastern Saline Wetlands are unique ecosystems endemic to the Salt and Rock Creek waters in Lancaster and Saunders County.
They provide an ecosystem services as well as habitat for endangered species such as the state endangered saltwort (Salicornia rubra) and federally endangered Salt Creek tiger beetle (Cicindela nevadica lincolniana).
Over 80 % of the saline wetlands are highly degraded and in recent years, the Saline Wetland Conservation Partnership has formed to conserve and restore the remaining saline wetland fragments, but there is limited information about inland saline wetland restoration. Purpose: Investigate techniques to better conserve …
Tom Curran, Phd, Frs, Named Executive Director Of Children's Research Institute, 2016 Children's Mercy Kansas City
Tom Curran, Phd, Frs, Named Executive Director Of Children's Research Institute, Children's Mercy Hospital
Our Story Continues
Tom Curran, PhD, FRS, has been named Chief Scientific Officer and Executive Director of the Children’s Mercy Children’s Research Institute (CRI), effective Feb. 1 [2016]
The Children’s Research Institute at Children’s Mercy Kansas City was established last year to build on the hospital’s century-long history in pediatric research and to focus the hospital’s future research efforts in four key areas:
- Pediatric Genomic Medicine
- Clinical Pharmacology
- Health Services and Outcomes
- Health Care Delivery
Biographical Feature: Clyde Thornsberry, Ph.D., 2016 Marquette University
Biographical Feature: Clyde Thornsberry, Ph.D., Erik Munson
Clinical Lab Sciences Faculty Research and Publications
No abstract provided.
Suboptimal Trichomonas Vaginalis Antigen Test Performance In A Low-Prevalence Sexually Transmitted Infection Community, 2016 Wheaton Franciscan Laboratory
Suboptimal Trichomonas Vaginalis Antigen Test Performance In A Low-Prevalence Sexually Transmitted Infection Community, Kimber L. Munson, Maureen Napierala, Erik Munson
Clinical Lab Sciences Faculty Research and Publications
Trichomonas vaginalis is the most common nonviral etiology of sexually transmitted infection (STI) worldwide. The OSOM Trichomonas rapid test (OSOM; Sekisui Diagnostics, San Diego, CA) is a rapid surrogate to microscopic analysis in symptomatic patients, but its performance in low-prevalence STI populations has been assessed on a limited basis in the literature. OSOM has widespread usage, as accreditation data from the College of American Pathologists report that over 300 participant laboratories utilize this assay on an annual basis. We sought to characterize the analytical and clinical performance of OSOM in a low-prevalence STI population on the basis of a commercial …
Models For Hsv Shedding Must Account For Two Levels Of Overdispersion, 2016 University of Washington - Seattle Campus
Models For Hsv Shedding Must Account For Two Levels Of Overdispersion, Amalia Magaret
UW Biostatistics Working Paper Series
We have frequently implemented crossover studies to evaluate new therapeutic interventions for genital herpes simplex virus infection. The outcome measured to assess the efficacy of interventions on herpes disease severity is the viral shedding rate, defined as the frequency of detection of HSV on the genital skin and mucosa. We performed a simulation study to ascertain whether our standard model, which we have used previously, was appropriately considering all the necessary features of the shedding data to provide correct inference. We simulated shedding data under our standard, validated assumptions and assessed the ability of 5 different models to reproduce the …
Systematic Errors In Intro Lab Video Analysis, 2016 Dordt College
Systematic Errors In Intro Lab Video Analysis, John Zwart, Kayt E. Frisch, Tim Martin
Faculty Work Comprehensive List
In video analysis lab experiments, students frequently find large discrepancies between results based on self-filmed videos and expected values (e.g. for g determined by a fit to projectile motion data). These differences are frequently far larger than the uncertainty calculated from their fit. Using an inexpensive point-and-shoot camera with a 4x optical zoom to record video, we investigated two possible causes of this error: the effect of placing the reference meter stick at a different object-to-camera distance and the effect of the motion of interest being in a plane not perpendicular to the camera lens. When we observed these phenomena …
Deep Sleep, Cognition, Body Weight, Body Temperature, And Behavioral Distress Responses To New Onset Psychosocial Stressors Are Blunted With Age In Male F344 Rats, 2016 University of Kentucky
Deep Sleep, Cognition, Body Weight, Body Temperature, And Behavioral Distress Responses To New Onset Psychosocial Stressors Are Blunted With Age In Male F344 Rats, Kendra E. Hargis
Theses and Dissertations--Pharmacology and Nutritional Sciences
Complaints associated with aging, including cognitive deficits and sleep loss, are highly prevalent and negatively impact quality of life. Further, with increased age, humans are also more likely to experience new-onset psychosocial stressors, such as divorce, loss of a spouse, and social isolation. Stress has detrimental consequences that in many ways parallel the effects of aging on sleep and cognition. The long-standing stress/ glucocorticoid hypotheses of brain aging posit that stress exposure exacerbates aging symptoms, and extensive prior studies have shown that early life stress exposure does worsen phenotypic aging symptoms. However, despite its prevalence in aged humans, little basic …
Isolation And Characterization Of Microbial Community Associated With Diadumene Lineata, The Orange-Striped Sea Anemone, 2016 Pace University
Isolation And Characterization Of Microbial Community Associated With Diadumene Lineata, The Orange-Striped Sea Anemone, Tiffany Lin, Andrew Weir
Student and Faculty Research Days
The orange-striped sea anemone, Diadumene lineata, is a marine invertebrate that can be found in the Northern Hemisphere. Distribution of Diadumene lineata ranges from Japan to the Gulf of Argentina. This invasive anemone originated from the Pacific Coast of Asia and serves as a host for a diverse microbial community including a photosynthetic alga. The epiphytic bacteria adhere to the outer surface as well as to the gastrovascular cavity of the host. The microbial community associated with Diadumene lineata is relatively unknown. This study attempted to isolate and identify bacteria commonly associated with this invasive marine invertebrate. Diadumene lineata was …
Privatization Of Biomedical Research: A Short Term Answer With Long Term Consequences, 2016 Nebraska College Preparatory Academy
Privatization Of Biomedical Research: A Short Term Answer With Long Term Consequences, Frederick Azalekor
Nebraska College Preparatory Academy: Senior Capstone Projects
Biomedical research owned by the government is now available to be owned by private institutions. This results in stagnant innovations because researchers have trouble with all the restrictions that are placed by private institutions. Privatization of biomedical research has short term positive effects but its negative effects are overarching and disastrous. One way to combat this, is for licenses to be deployed slowly with future consequences in mind.
• Privatization has short term benefits but long term disadvantages are disastrous. • To reduce damaging effect, privatization must be deployed slowly and carefully. • Patents or proprietary ownership must be given …
Role Of Vav2 In Podocyte Inflammasome Activation And Glomerular Injury During Hyperhomocysteinemia, 2016 VCU
Role Of Vav2 In Podocyte Inflammasome Activation And Glomerular Injury During Hyperhomocysteinemia, Sabena Conley
Theses and Dissertations
Hyperhomocysteinemia (hHcys) is a widely known pathogenic factor in the progression of end-stage renal disease (ESRD) and it is also associated with an increased risk for injurious cardiovascular pathologies during ESRD. HHcys is linked to the formation and activation of the NOD-like receptor protein 3 (NLRP3) inflammasome, characterized as a critical early mechanism initiating the inflammatory response. NADPH oxidase (NOX)-derived reactive oxygen species (ROS) mediate the activation of the NLRP3 inflammasome in podocytes in response to elevated levels of homocysteine (Hcys) in vitro and in vivo. However, it remains unknown how NLRP3 inflammasome activation is triggered by NOX. The …
Pedagogy For The Pedosphere, 2016 Roger Williams University
Pedagogy For The Pedosphere, Loren B. Byrne, Rachel K. Thiet, V Bala Chaudhary
Arts & Sciences Faculty Publications
No abstract provided.
Hexokinase Ii Localization Is Independent Of Ampk Activation In Hela Cells, 2016 Rowan University
Hexokinase Ii Localization Is Independent Of Ampk Activation In Hela Cells, Alyssa Brown
Graduate School of Biomedical Sciences Theses and Dissertations
In order for a cancer cell to thrive, it must alter its metabolism to produce the energy needed for rapid growth. Cells accomplish this by the Warburg Effect, or switching metabolism to aerobic glycolysis, where a cell can rapidly break down sugar into ATP, lactic acid and additional byproducts. Hexokinase 2, the enzyme that catalyzes the first committed step of glycolysis, may also be upregulated in cancer cells to increase glucose breakdown. Similar proteins for metabolism are found in both S. cerevisiae and mammalian cells. S. cerevisiae regulates metabolism through glucose repression, by Snf1 (mammalian homolog: AMPK) activation, which aids …
Development Of A Low-Cost Arduino-Based Sonde For Coastal Applications, 2016 Dauphin Island Sea Lab
Development Of A Low-Cost Arduino-Based Sonde For Coastal Applications, Grant Lockridge, Brian Dzwonkowski, Reid Nelson, Sean P. Powers
University Faculty and Staff Publications
This project addresses the need for an expansion in the monitoring of marine environments by providing a detailed description of a low cost, robust, user friendly sonde, built on Arduino Mega 2560 (Mega) and Arduino Uno (Uno) platforms. The sonde can be made without specialized tools or training and can be easily modified to meet individual application requirements. The platform allows for internal logging of multiple parameters of which conductivity, temperature, and GPS position are demonstrated. Two design configurations for different coastal hydrographic applications are highlighted to show the robust and versatile nature of this sensor platform. The initial sonde …
Temporal Trends Of Corporate Sponsorship In Medical Research, 2016 Bowling Green State University
Temporal Trends Of Corporate Sponsorship In Medical Research, Elijah Bodey
Honors Projects
Data will be collected from medical journals to assessed changes in the nature and prevalence of corporate sponsorship. The journals that will be reviewed are the Journal of the American Medical Association (JAMA), the New England Journal of Medicine (NEJM), the British Medical Journal (BMJ), and the Lancet. These journals were chosen because of their high impact on medical research representing both American and British Medical editorials. It has been shown that corporate sponsorship has been associated with bias results (Kjaergard et al 2002). Changes in the nature of corporate sponsorship would be linked to changes in economic climate and …