Quantitative Reagent-Free Detection Of Fibrinogen Levels In Human Blood Plasma Using Raman Spectroscopy,
2012
Technological University Dublin
Quantitative Reagent-Free Detection Of Fibrinogen Levels In Human Blood Plasma Using Raman Spectroscopy, Kelvin Poon, Fiona Lyng, Peter Knief, Orla L. Howe, Aidan Meade, James Curtin, Hugh Byrne, Joseph Vaughan
Articles
Fibrinogen assays are commonly used as part of clinical screening tests to investigate haemorrhagic states, for detection of disseminated intravascular coagulation and as a predictor of a variety of cardiovascular events. The Clauss assay, which measures thrombin clotting time, is the most commonly used method for measuring fibrinogen levels. Nevertheless, inconsistencies are present in inter-manufacturer reagent sources, calibration standards and methodologies. Automated coagulation analysers, which measure changes in optical density during the prothrombin time (PT-Fg), have found use in many hospitals. However, the PT-Fg method is found to give falsely elevated values due to varying choices of calibrants, reagents and …
A Thousand Tiny Pieces: The Federal Circuit’S Fractured Myriad Ruling, Lessons To Be Learned, And The Way Forward,
2012
American University Washington College of Law, Washington D.C.
A Thousand Tiny Pieces: The Federal Circuit’S Fractured Myriad Ruling, Lessons To Be Learned, And The Way Forward, Jonathan R. K. Stroud
IP Theory
No abstract provided.
Amelioration Of Amyloid Burden In Advanced Human And Mouse Alzheimer's Disease Brains By Oral Delivery Of Myelin Basic Protein Bioencapsulated In Plant Cells,
2012
University of Central Florida
Amelioration Of Amyloid Burden In Advanced Human And Mouse Alzheimer's Disease Brains By Oral Delivery Of Myelin Basic Protein Bioencapsulated In Plant Cells, Neha Kohli
Electronic Theses and Dissertations
One of the pathological hallmarks of Alzheimer's disease (AD) is the amyloid plaque deposition in aging brains by aggregation of amyloid-β (Aβ) peptides. In this study, the effect of chloroplast derived myelin basic protein (MBP) fused with cholera toxin subunit B (CTB) was investigated in advanced diseased stage of human and mouse AD brains. The CTB-fusion protein in chloroplasts facilitates transmucosal delivery in the gut by the natural binding ability of CTB pentameric form with GM1 receptors on the intestinal epithelium. Further, bioencapsulation of the MBP within plant cells confers protection from enzymes and acids in the digestive system. Here, …
Identification Of Novel Antimalarial Scaffolds From Marine Natural Products,
2012
University of Central Florida
Identification Of Novel Antimalarial Scaffolds From Marine Natural Products, Bracken Roberts
Electronic Theses and Dissertations
Malaria, the disease caused by Plasmodium sp., claims the lives of over 1 million people every year, with Plasmodium falciparum causing the highest morbidity. Rapidly acquiring drug resistance is threatening to exhaust our antimalarial drug arsenal and already requires the utilization of combination drug therapy in most cases. The global need for novel antimalarial chemical scaffolds has never been greater. Screening of natural product libraries is known to have higher hit rates than synthetic chemical libraries. This elevated hit rate is somewhat attributed to the greater biodiversity available in natural products. Marine life is the most biodiverse system on the …
Light-Activated Binary Nucleotide Reagent For Inactivation Of Dna Polymerase,
2012
University of Central Florida
Light-Activated Binary Nucleotide Reagent For Inactivation Of Dna Polymerase, Evan M. Cornett
Electronic Theses and Dissertations
This work explores a binary reagent approach to increase the specificity of covalent inhibitors. In this approach, two ligand analogs equipped with inert pre-reactive groups specifically bind a target biopolymer. The binding event brings the pre-reactive groups in proximity with each other. The two groups react, generating active chemical intermediates that covalently modify and inactivate the target. In the present study we compare the new approach with the traditional single-component reagent strategy using DNA polymerase from bacteriophage T4 as a model target biopolymer. We report the design and synthesis of two analogs of deoxythymidine triphosphate, a natural DNA polymerase substrate. …
Usc Image Center,
2012
University of South Carolina - Columbia
Powers Of Ten,
2012
University of South Carolina - Columbia
Imaging In 3-D,
2012
University of South Carolina - Columbia
Questioning Images,
2012
University of South Carolina - Columbia
How Small Is Small?,
2012
University of South Carolina - Columbia
Why Do We Collect?,
2012
University of South Carolina - Columbia
Why Do We Collect?, Allison Marsh
Section 2: Imaging the Microscopic
No abstract provided.
Spotlight On Usc: A.C. Moore Herbarium,
2012
University of South Carolina - Columbia
Spotlight On Usc: A.C. Moore Herbarium, Allison Marsh
Section 2: Imaging the Microscopic
No abstract provided.
Imaging And Aesthetics,
2012
University of South Carolina - Columbia
Imaging And Aesthetics, Allison Marsh
Section 2: Imaging the Microscopic
No abstract provided.
Observing The Minuscule,
2012
University of South Carolina - Columbia
Observing The Minuscule, Allison Marsh
Section 2: Imaging the Microscopic
No abstract provided.
Spotlight On Usc: South Carolina Institute For Anthropology And Archaeology,
2012
University of South Carolina - Columbia
Spotlight On Usc: South Carolina Institute For Anthropology And Archaeology, Allison Marsh
Section 4: Imaging the Concealed
No abstract provided.
Mapping The Ocean Frontier,
2012
University of South Carolina - Columbia
Mapping The Ocean Frontier, Allison Marsh
Section 4: Imaging the Concealed
No abstract provided.
Seeing With Sound,
2012
University of South Carolina - Columbia
Seeing With Sound, Allison Marsh
Section 4: Imaging the Concealed
No abstract provided.
World Ocean Floor, Courtesy Of The Library Of Congress,
2012
University of South Carolina - Columbia
World Ocean Floor, Courtesy Of The Library Of Congress, Allison Marsh
Section 4: Imaging the Concealed
No abstract provided.
Marie Tharp At Her Drafting Table, Courtesy Of The Lamont-Doherty Earth Observatory, Earth Institute, Columbia University,
2012
University of South Carolina - Columbia
Marie Tharp At Her Drafting Table, Courtesy Of The Lamont-Doherty Earth Observatory, Earth Institute, Columbia University, Allison Marsh
Section 4: Imaging the Concealed
No abstract provided.
Conclusion Panel,
2012
University of South Carolina - Columbia
