Do The Evolution: The Effect Of Ksr V. Teleflex On Biotechnology,
2017
University of Oklahoma College of Law
Do The Evolution: The Effect Of Ksr V. Teleflex On Biotechnology, Josh Harrison
Oklahoma Journal of Law and Technology
No abstract provided.
Adapting To The Changing World Of Biotechnology: Syngenta Ag Mir162 Corn Litigation As Regulation By Litigation,
2017
Texas A&M University School of Law
Adapting To The Changing World Of Biotechnology: Syngenta Ag Mir162 Corn Litigation As Regulation By Litigation, Paul Goeringer
Texas A&M Law Review
Agriculture has relied on plant breeding to improve genetics since the first domestication of agricultural plants 10,000 years ago. More recently, Gregor Mendel and his hybridization experiments on peas led to what we know as modern genetics. The rise in recombinantDNA technology has opened up many possibilities in plant breeding, including Roundup Ready technology and crop varieties designed to resist a number of pests. At the same time, governments and the private sector have sought to institute regulations for handling the releases of new biotechnology to ensure the technologies will have limited environmental impacts and provide safe foods to the …
The Gmo/Ge Debate,
2017
Texas A&M University School of Law
The Gmo/Ge Debate, Joanna K. Sax
Texas A&M Law Review
We live longer and healthier lives because advances in science create easier and better ways to sustain and survive. Society has an intricate relationship with biotechnology. Vaccines save lives. Fluoridated water decreases dental issues. Antibiotics treat bacterial infections. Nuclear power is a form of clean energy. With any emerging technology, the benefits do not exist in a vacuum, thus, negative consequences result as well. Our widespread uses of antibiotics are creating antibiotic-resistant strains of bacteria. Our research into nuclear energy also facilitated the creation of nuclear bombs. Perhaps it is human nature to use scientific advances for good and for …
Recognizing Challenges And Opportunities In The Quest To End Hunger,
2017
Texas A&M University School of Law
Recognizing Challenges And Opportunities In The Quest To End Hunger, Jennifer Williams Zwagerman
Texas A&M Law Review
As an attorney and professor that does not focus on intellectual property law, I was a bit apprehensive about providing a keynote address for a Symposium focusing on “Agriculture, Intellectual Property, and Feeding the World in the 21st Century.” As I thought about this topic, knowing that there were other speakers who would focus more on the IP issues and technical aspects of various topics, I kept coming back to the importance of technology as we worktowards the goal of feeding the world, and the many ways in which innovation plays a role in meeting that goal. It also brought …
Cross-Species Complementation Reveals Conserved Functions
For Early Flowering 3 Between Monocots And Dicots,
2017
Donald Danforth Plant Science Center
Cross-Species Complementation Reveals Conserved Functions For Early Flowering 3 Between Monocots And Dicots, He Huang, Malia A. Gehan, Sarah E. Huss, Sohpie Alvarez, Cesar Lizarraga, Ellen L. Gruebbling, John Gierer, Michael J. Naldrett, Rebacca K. Bindbeutel, Bradley S. Evans, Todd C. Mockler, Dmitri A. Nusinow
Nebraska Center for Biotechnology: Faculty and Staff Publications
Plant responses to the environment are shaped by external stimuli and internal signaling pathways. In both the model plant Arabidopsis thaliana (Arabidopsis) and crop species, circadian clock factors are critical for growth, flowering, and circadian rhythms. Outside of Arabidopsis, however, little is known about the molecular function of clock gene products. Therefore, we sought to compare the function of Brachypodium distachyon (Brachypodium) and Setaria viridis (Setaria) orthologs of EARLY FLOWERING 3, a key clock gene in Arabidopsis. To identify both cycling genes and putative ELF3 functional orthologs in Setaria, a …
Dusquetide: Reduction In Oral Mucositis Associated With Enduring Ancillary Benefits In Tumor Resolution And Decreased Mortality In Head And Neck Cancer Patients,
2017
University of Kentucky
Dusquetide: Reduction In Oral Mucositis Associated With Enduring Ancillary Benefits In Tumor Resolution And Decreased Mortality In Head And Neck Cancer Patients, Mahesh Kudrimoti, Amarinthia Curtis, Samar Azawi, Francis Worden, Sanford Katz, Douglas Adkins, Marcelo Bonomi, Zack Scott, Jenna Elder, Stephen T. Sonis, Richard Straube, Oreola Donini
Radiation Medicine Faculty Publications
Innate immunity is a key component in the pathogenesis of oral mucositis, a universal toxicity of chemoradiation therapy (CRT). Dusquetide, a novel Innate Defense Regulator, has demonstrated both nonclinical and clinical efficacy in ameliorating severe oral mucositis (SOM). Long term follow-up studies from the Phase 2 clinical study evaluating dusquetide as a treatment for SOM in head and neck cancer (HNC) patients receiving CRT have now been completed. Extended analysis indicates that dusquetide therapy was well-tolerated and did not contribute to increased infection, tumor growth or mortality. Potential ancillary benefits of duquetide therapy were also identified.
Damage-Free Peripheral Nerve Stimulation By 12-Ns Pulsed Electric Field,
2017
Old Dominion University
Damage-Free Peripheral Nerve Stimulation By 12-Ns Pulsed Electric Field, Maura Casciola, Shu Xiao, Andrei G. Pakhomov
Bioelectrics Publications
Modern technologies enable deep tissue focusing of nanosecond pulsed electric field (nsPEF) for non-invasive nerve and muscle stimulation. However, it is not known if PEF orders of magnitude shorter than the activation time of voltage-gated sodium channels (VGSC) would evoke action potentials (APs). One plausible scenario requires the loss of membrane integrity (electroporation) and resulting depolarization as an intermediate step. We report, for the first time, that the excitation of a peripheral nerve can be accomplished by 12-ns PEF without electroporation. 12-ns stimuli at 4.1-11 kV (3.3-8.8 kV/cm) evoked APs similarly to conventional stimuli (100-250 mus, 1-5 V, 103-515 V/m), …
Delayed Hypersensitivity To Nanosecond Pulsed Electric Field In Electroporated Cells,
2017
Old Dominion University
Delayed Hypersensitivity To Nanosecond Pulsed Electric Field In Electroporated Cells, Sarah D. Jensen, Vera A. Khorokhorina, Claudia Muratori, Andrei G. Pakhomov, Olga N. Pakhomova
Bioelectrics Publications
We demonstrate that conditioning of mammalian cells by electroporation with nanosecond pulsed electric field (nsPEF) facilitates their response to the next nsPEF treatment. The experiments were designed to unambiguously separate the electroporation-induced sensitization and desensitization effects. Electroporation was achieved by bursts of 300-ns, 9 kV/cm pulses (50 Hz, n = 3–100) and quantified by propidium dye uptake within 11 min after the nsPEF exposure. We observed either sensitization to nsPEF or no change (when the conditioning was either too weak or too intense, or when the wait time after conditioning was too short). Within studied limits, conditioning never caused desensitization. …
Controllable Moderate Heating Enhances The Therapeutic Efficacy Of Irreversible Electroporation For Pancreatic Cancer,
2017
Old Dominion University
Controllable Moderate Heating Enhances The Therapeutic Efficacy Of Irreversible Electroporation For Pancreatic Cancer, Chelsea M. Edelblute, James Hornef, Niculina I. Burcus, Thomas Norman, Stephen J. Beebe, Karl Schoenbach, Richard Heller, Chunqi Jiang, Sigi Guo
Bioelectrics Publications
Irreversible electroporation (IRE) as a non-thermal tumor ablation technology has been studied for the treatment of pancreatic carcinoma and has shown a significant survival benefit. We discovered that moderate heating (MH) at 43°C for 1-2 minutes significantly enhanced ex vivo IRE tumor ablation of Pan02 cells by 5.67-fold at 750 V/cm and by 1.67-fold at 1500 V/cm. This amount of heating alone did not cause cell death. An integrated IRE system with controllable laser heating and tumor impedance monitoring was developed to treat mouse ectopic pancreatic cancer. With this novel IRE system, we were able to heat and maintain the …
Mutagenesis Of Human Alpha-Galactosidase A For The Treatment Of Fabry Disease,
2017
CUNY Graduate Center
Mutagenesis Of Human Alpha-Galactosidase A For The Treatment Of Fabry Disease, Erin Stokes
Dissertations, Theses, and Capstone Projects
Fabry disease is an X-linked lysosomal storage disorder caused by the deficiency of the enzyme, α-galactosidase A, which results in the accumulation of the lipid substrate. This accumulation results in obstruction of blood flow in patients and early demise at approximately 40-60 years of age. There is currently only one FDA approved treatment (Fabrazyme) classified as an enzyme replacement therapy. However, approximately 88% of patients experience a severe immune response that, rarely, can be fatal and is a huge cost burden at average $250,000 a year per patient. The structure of α-galactosidase A has been previously determined to be a …
Evaluation Of Cooking Oil As Processing Addtive For Natural Rubber,
2017
Universiti Brunei Darussalam
Evaluation Of Cooking Oil As Processing Addtive For Natural Rubber, Syamin Y. M., Azemi S., Dzaraini K.
ASEAN Journal on Science and Technology for Development
It was reported recently that high amount of aromatic ring or number of polycyclic aromatic hydrocarbon compounds found in aromatic oil are carcinogenic. This paper discusses the work to evaluate the Malaysian cooking oil as an alternative option to be used as process oil since cooking oil is safe to use and non-toxic. The performance of cooking oil is compared againstaromatic and paraffinioils. The results showed that rubber compounds containing cooking oil produced almostsimilar cure characteristicsas those produced by aromatic and paraffinioils indicating that it did not interfere with the vulcanization reaction. The physical properties of the vulcanizates containing cooking …
Prevalence Of Diarrhoeal Diseases Among Children Under Five Years In East African Countries From 2012–2017,
2017
Universiti Brunei Darussalam
Prevalence Of Diarrhoeal Diseases Among Children Under Five Years In East African Countries From 2012–2017, Elmi O. E., Dioso R. (Ii) P.
ASEAN Journal on Science and Technology for Development
This meta-analysis analyzed the prevalence of diarrheoal diseases among children less than fiveyears in three selected Eas African countries from 2012–2017. Search engines used Google Scholar, Proquest,and PubMed. Primarily, 300 studes were selected; hence 297 were eliminated using inclusion and exclusion criteria. The PICO (population, intervention, comparison, and outcome) guide helped in the analysis of the three selected stdies. The prevalence of diarrhoea among children less than fiveyears in the three selected EastAfrican countries from 2012 to 2017, averaged to 27% range from a minimum of 11% to a maximum of 54% of the 5478 total respondents (OR 2.07). The …
Nursing Care For A Patient With Nstemi Admitted To The Coronary Care Unit For Percutaneous Coronary Intervention — A Case Study,
2017
Universiti Brunei Darussalam
Nursing Care For A Patient With Nstemi Admitted To The Coronary Care Unit For Percutaneous Coronary Intervention — A Case Study, Siti Maryati M. S., Dioso R. (Ii) P.
ASEAN Journal on Science and Technology for Development
This case studyaims to demonstrateclinical nursing skills to a patient with myocardial infarction admitted for percutaneous coronary intervention. Nursing care for this patient startedwith a physical assessment and laboratory invesigation analysis. This evaluation was necessary to develop a nursing care plan. The activities in the ward enumerated the medications provided, and the details of the vital signs monitored hourly. The patient was sent to cardiac catheter laboratory at 1030H. From the cardiac catheter laboratory post-percutaneouscoronary intervention to the mid-right coronary artery (1 Drug-Eluting Stent) he was transferred out to Telemetry unit on 11 August2016 at 1500H with Terumo band hemostatic …
Hydrocarbons As Refrigerants―A Review,
2017
Universiti Brunei Darussalam
Hydrocarbons As Refrigerants―A Review, Koh J. H., Zakaria Z.
ASEAN Journal on Science and Technology for Development
Refrigerants used in air conditioning and refrigeration (AC&R) indusries have come full circle since the beginning of the industrialrevolution. With concern on issues relating to the environment such as the global warming and climate change issues, we should finda better alternative than to continue using these refrigerants that cause global warming and ozone depletion. AC&R industryplayers have blended in by introducing some new equipment and components that are specificallydesigned for hydrocarbon (HC) use. Mostnew refrigerators sold in Malaysia are already equipped with isobutane [a hydrocarbon designated as R-600a by the American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE) standards]as …
Metalloproteases Of The Inner Mitochondrial Membrane,
2017
University of Nebraska - Lincoln
Metalloproteases Of The Inner Mitochondrial Membrane, Roman M. Levytskyy, Iryna Bohovych, Oleh Khalimonchuk
Department of Biochemistry: Faculty Publications
The inner mitochondrial membrane (IM) is among most protein-rich cellular compartments. The metastable IM sub-proteome where the concentration of proteins is approaching oversaturation creates a challenging protein folding environment with high probability for protein malfunction or aggregation. Failure to maintain protein homeostasis in such a setting can impair functional integrity of the mitochondria and drive clinical manifestations. The IM is equipped with a series of highly conserved, proteolytic complexes dedicated to the maintenance of normal protein homeostasis within this mitochondrial sub-compartment. Particularly important is a group of membrane-anchored metallopeptidases commonly known as m-AAA and i-AAA proteases, and the ATP-independent Oma1 …
Increasing Serum Cholesterol Level Among Sri Lankan Adult Obese Patients Admitted To Medical Wards: A Cross-Sectional Study,
2017
Universiti Brunei Darussalam
Increasing Serum Cholesterol Level Among Sri Lankan Adult Obese Patients Admitted To Medical Wards: A Cross-Sectional Study, Dioso R. (Ii) P., Shalina K., Judenimal K.
ASEAN Journal on Science and Technology for Development
This research identifid the factors affcting the widespread of the level of serum cholestrol among adult obese patients admitted to government hospitals in the easternpart of Sri Lanka, and identifie the number of adults obese patients with increasing serum cholesterollevel. A descriptive cross-sectional studydesign was used. Convenience sampling technique helped select 150 patients in medical wards and clinics of two government hospitals in the easternprovince of Sri Lanka, and Questionnaireswere distributedfor data analysis. Overall findingsof 150 obese patients regarding increasing serum cholestrol level admitted in the medical wards and follow-up at medical clinics had 59% in moderate risk, 36% with …
The Role Of Interactions Of Long Non-Coding Rnas
And Heterogeneous Nuclear Ribonucleoproteins In
Regulating Cellular Functions,
2017
University of Nebraska - Lincoln
The Role Of Interactions Of Long Non-Coding Rnas And Heterogeneous Nuclear Ribonucleoproteins In Regulating Cellular Functions, Xinghui Sun, Mohamed Sham Shihabudeen Haider Ali, Matthew Moran
Department of Biochemistry: Faculty Publications
Long non-coding RNAs (lncRNAs) are emerging as critical regulators of various biological processes and human diseases. The mechanisms of action involve their interactions with proteins, RNA and genomic DNA. Most lncRNAs display strong nuclear localization. Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a large family of RNA-binding proteins that are important for multiple aspects of nucleic acid metabolism. hnRNPs are also predominantly expressed in the nucleus. This review discusses the interactions of lncRNAs and hnRNPs in regulating gene expression at transcriptional and post-transcriptional levels or by changing genomic structure, highlighting their involvements in glucose and lipid metabolism, immune response, DNA damage response, …
Low-Cost Diagnostics: A Novel Aptamer Screening Process,
2017
Purdue University
Low-Cost Diagnostics: A Novel Aptamer Screening Process, Junkai Xie, Kalie Janece Dicks, Oscar C. Sanchez-Medina, Chongli Yuan
The Summer Undergraduate Research Fellowship (SURF) Symposium
Low-Cost diagnostic and screening tools are of vital importance for low resources countries like those in Africa. DNA aptamers are becoming an important detection analytical tool to recognize small molecule targets, drugs and metabolites. Compared to alternative recognition motifs, such as antibody, protein and peptides, aptamers are cheaper to produce via chemical synthesis, stable at room temperature and relatively faster in R&D lead time (year). Over the past 15 years, various aptamer based sensors have been developed. Conventionally, aptamers were screened via a Systematic Evolution of Ligands by EXponential enrichment(SELEX) process. We have improved the SELEX process to improve the …
Establishing A Lung Model For Evaluation Of Engineered Lung Microbiome Therapies,
2017
Purdue University
Establishing A Lung Model For Evaluation Of Engineered Lung Microbiome Therapies, Kathryn F. Atherton, Stephen Miloro, Jenna Rickus
The Summer Undergraduate Research Fellowship (SURF) Symposium
Benzene, a toxin and carcinogen found in air polluted by cigarette smoke, car exhaust, and industrial processes, is associated with the development of leukemia and lymphoma. Other than avoiding exposure, there is no current method to deter the effects of benzene. One potential strategy to prevent these effects is to engineer the bacteria of the human lung microbiome to degrade benzene. To evaluate this novel approach, we must verify that the bacteria remain viable within the lung microenvironment. To do so, lungs were harvested from rats and swabbed to determine the contents of the original lung microbiome. Then green fluorescent …
Fret Biosensors: Engineering Fluorescent Proteins As Biological Tools For Studying Parkinson’S Disease,
2017
Purdue University
Fret Biosensors: Engineering Fluorescent Proteins As Biological Tools For Studying Parkinson’S Disease, Nathan J. Leroy, Jacob R. Norley, Saranya Radhakrishnan, Mathew Tantama
The Summer Undergraduate Research Fellowship (SURF) Symposium
Parkinson’s Disease (PD) is a common neurodegenerative disease with over 200,000 new cases each year. In general, the cause of the disease is unknown, but oxidative stress inside of neurons has been associated with the disease’s pathology for some time. Currently, techniques to study the onset of PD inside of neurons are limited. This makes treatments and causes difficult to discover. One solution to this has been fluorescent protein biosensors. In short, these proteins can be engineered to glow when a certain state is achieved inside a cell. The present research discusses the engineering of a genetically-encoded fluorescent protein (FP) …
