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Full-Text Articles in Medicine and Health Sciences
Evaluation Of Metabolic Changes In Fdg Pet/Ct Imaging After Mrna-Based Covid-19 Vaccination, Serkan İşgören, Gi̇zem Köroğlu, Gözde Dağliöz Görür, Hakan Demi̇r
Evaluation Of Metabolic Changes In Fdg Pet/Ct Imaging After Mrna-Based Covid-19 Vaccination, Serkan İşgören, Gi̇zem Köroğlu, Gözde Dağliöz Görür, Hakan Demi̇r
Turkish Journal of Medical Sciences
Background/aim: It isimportant to evaluate the vaccine-related metabolic changes on FDG PET/CT to avoid confusing results. We here aimed to assess the frequency and intensity of regional and systemic metabolic PET/CT changes of patients who received the mRNAbased COVID-19 vaccine (BNT162b2-Pfizer/BioNTech) and to analyze possible factors affecting these changes. Materials and methods: Among the patients who underwent FDG PET/CT for any indication in our department between July 2021 and December 2021, 129 volunteer patients with a history of COVID-19 vaccination were included in this prospective observational study. Bilateral axillary lymph nodes, ipsilateral deltoid muscle, bone marrow, spleen, thyroid, and liver …
A Comparison Of Antibody Response In Kidney Transplant Recipients And Healthcare Workers Who Had Pcr-Confirmed Covid-19 Infection, Mevlüt Tamer Di̇ncer, Necmi̇ Eren, Ahmet Murt, Nuri̇ye Yildiz, Şeyda Gül Özcan, Meti̇n Ergül, Si̇bel Gökçay Bek, Zeynep Atli, Si̇nan Trabulus, Erkan Dervi̇şoğlu, Hamdi̇ Levent Doğanay, Nurhan Seyahi̇
A Comparison Of Antibody Response In Kidney Transplant Recipients And Healthcare Workers Who Had Pcr-Confirmed Covid-19 Infection, Mevlüt Tamer Di̇ncer, Necmi̇ Eren, Ahmet Murt, Nuri̇ye Yildiz, Şeyda Gül Özcan, Meti̇n Ergül, Si̇bel Gökçay Bek, Zeynep Atli, Si̇nan Trabulus, Erkan Dervi̇şoğlu, Hamdi̇ Levent Doğanay, Nurhan Seyahi̇
Turkish Journal of Medical Sciences
Background/aim: Data on antibody response following COVID-19 in kidney transplant recipients is scarce. This crosssectional study aims to investigate the antibody response to COVID-19 among kidney transplant recipients. Materials and methods: We recruited 46 kidney transplant recipients with RT-PCR-confirmed COVID-19 and 45 recipients without COVID-19 history. We also constructed two control groups (COVID-19 positive and negative) from a historical cohort of healthcare workers. We used age and sex-based propensity score matching to select the eligible subjects to the control groups. We measured the SARS-CoV-2 IgG levels quantitatively using the Abbott ARCHITECT system. An antibody level above 1.4 S/C was defined …
Covid-19 In Pediatric Nephrology Centers In Turkey, Emre Leventoğlu, Yeşi̇m Özdemi̇r Ati̇kel, Hülya Nalçacioğlu, İsmai̇l Dursun, Hasan Dursun, Zeynep Nagehan Yürük Yildirim, Nurdan Yildiz, Gülşah Kaya Aksoy, Mehmet Taşdemi̇r, Mehtap Çelakil, Belti̇nge Demi̇rci̇oğlu Kiliç, Şenay Zirhli Selçuk, Nur Canpolat, Evri̇m Kargin Çakici, Sare Gülfem Özlü
Covid-19 In Pediatric Nephrology Centers In Turkey, Emre Leventoğlu, Yeşi̇m Özdemi̇r Ati̇kel, Hülya Nalçacioğlu, İsmai̇l Dursun, Hasan Dursun, Zeynep Nagehan Yürük Yildirim, Nurdan Yildiz, Gülşah Kaya Aksoy, Mehmet Taşdemi̇r, Mehtap Çelakil, Belti̇nge Demi̇rci̇oğlu Kiliç, Şenay Zirhli Selçuk, Nur Canpolat, Evri̇m Kargin Çakici, Sare Gülfem Özlü
Turkish Journal of Medical Sciences
Background/aim: There is limited data on COVID-19 disease in children with kidney disease. We aimed to investigate the characteristics and prognosis of COVID-19 in pediatric nephrology patients in Turkey. Materials and methods: This was a national, multicenter, retrospective cohort study based on an online survey evaluating the data between 11th March 2020 and 11th March 2021 as an initial step of a detailed pediatric nephrology COVID-19 registry. Results: Two hundred and three patients (89 girls and 114 boys) were diagnosed with COVID-19. One-third of these patients (36.9%) were between 10-15 years old. Half of the patients were on kidney replacement …
Favorable Efficacy Of Adalimumab Treatment In Experimental Acute Pancreatitis Model, Başak Çakir Güney, Alpaslan Tanoğlu, Murat Yeni̇çeri̇, Zafer Çirak, Ayşe Gökçen Sade, Yeşi̇m Önal Taştan, Zeli̇ha Seri̇ndağ, Mustafa Kaplan
Favorable Efficacy Of Adalimumab Treatment In Experimental Acute Pancreatitis Model, Başak Çakir Güney, Alpaslan Tanoğlu, Murat Yeni̇çeri̇, Zafer Çirak, Ayşe Gökçen Sade, Yeşi̇m Önal Taştan, Zeli̇ha Seri̇ndağ, Mustafa Kaplan
Turkish Journal of Medical Sciences
Background/aim: Acute pancreatitis is a clinical picture with a wide range of symptoms from mild inflammation to multiorgan failure and death. The aim of this study is to investigate the effects of Adalimumab (ADA) on inflammation and apoptosis in a cerulein-induced acute pancreatitis model in rats. Material and methods: Experimental cerulein-induced acute pancreatitis model was created by applying 4 intraperitoneal cerulein injections at 1-h intervals. A total of 40 rats, 8 in each group, were randomly distributed into five groups. In the groups that ADA treatment was given, two different doses of ADA were administered 5 mg/kg and 20 mg/kg …
The Relationship Between Morning Blood Pressure Surge And Asymptomatic Episodes Of Paroxysmal Atrial Fibrillation In Patients With Systemic Arterial Hypertension, Ümmü Taş, Sedat Taş, İdi̇l Yavuz
The Relationship Between Morning Blood Pressure Surge And Asymptomatic Episodes Of Paroxysmal Atrial Fibrillation In Patients With Systemic Arterial Hypertension, Ümmü Taş, Sedat Taş, İdi̇l Yavuz
Turkish Journal of Medical Sciences
Background/aim: Hypertension is a known risk factor for developing atrial fibrillation. However, there is limited data to investigate the association between morning blood pressure surge (MBPS) and paroxysmal atrial fibrillation (PAF). We conducted the present study to determine whether there is a relationship between asymptomatic PAF and MBPS and whether MBPS may be a predictor of asymptomatic PAF episodes. Materials and methods: This prospective study comprised 264 adult patients who were newly diagnosed with essential hypertension or were previously diagnosed but not receiving regular antihypertensive therapy. We evaluated the patients in 2 groups according to their 24-h electrocardiography monitoring results: …
Factors Affecting Patient-Acceptable Symptom States And Treatment Decision In Familial Mediterranean Fever, Derya Yildirim, İbrahi̇m Vasi̇, Erdi̇ Tahta, Riza Can Kardaş, Burcugül Özkiziltaş, Hami̇t Küçük, Mehmet Aki̇f Öztürk, Şemi̇nur Haznedaroğlu, Berna Göker, Abdurrahman Tufan
Factors Affecting Patient-Acceptable Symptom States And Treatment Decision In Familial Mediterranean Fever, Derya Yildirim, İbrahi̇m Vasi̇, Erdi̇ Tahta, Riza Can Kardaş, Burcugül Özkiziltaş, Hami̇t Küçük, Mehmet Aki̇f Öztürk, Şemi̇nur Haznedaroğlu, Berna Göker, Abdurrahman Tufan
Turkish Journal of Medical Sciences
Background/aim: Familial Mediterranean fever [FMF] is the most common autoinflammatory disease characterized by inflammatory attacks of fever and polyserositis. Patients' quality of life is significantly affected due to recurrent excruciating pain attacks and complications. This study is performed to evaluate the parameters most affecting patients' satisfaction from treatment. Materials and methods: Three hundred and forty-six consecutive patients diagnosed with FMF were enrolled in this study. Current treatment, acute phase proteins, number, type, and severity of predominant attacks, absenteeism from work/school in the last three months were recorded, and the participants were asked whether they needed additional treatment to evaluate Patient …
Short-Term Impact Of The Covid-19 Pandemic On The Global And Turkish Economy, Ömer Açikgöz, Asli Günay
Short-Term Impact Of The Covid-19 Pandemic On The Global And Turkish Economy, Ömer Açikgöz, Asli Günay
Turkish Journal of Medical Sciences
Background/aim: The Covid-19 pandemic is one of those rare events that affects everyone on earth and changes our lives. The pandemic, which has killed over four million people worldwide, is putting unprecedented pressure on governments to maintain essential health and social services, as well as keep their economies running, even as the virus threatens people's daily life on every level. Thus, the purpose of this study is to discuss the short-term economic impact of the pandemic by assessing its costs using official economic data for both the world and Turkey. Furthermore, this research highlights possible economic, social, and political pathways …
Global Health Emergencies During The Pandemic And Their Solutions, İrfan Şencan, Di̇lek Bulut, İsmai̇l Hakki Şencan, Canan Ağalar
Global Health Emergencies During The Pandemic And Their Solutions, İrfan Şencan, Di̇lek Bulut, İsmai̇l Hakki Şencan, Canan Ağalar
Turkish Journal of Medical Sciences
In this review, we evaluated health care problems, which were not common before pandemic outbreak but have been common issues after its appereance and approaches to control pandemic considering its influences on people. We revised current health care developing approaches under the light of experience obtained throughout the pandemic so far. The aim is to be prepared in advance for possible upcoming pandemics. As in Covid 19 pandemics, such long lasting and widely affecting situations, durability is also very important together with flexibility and quickness. To provide durability, we need global policies taking the health to its center as well …
Nonpharmaceutical Interventions In Turkey And Worldwide During Covid-19 Pandemic, Mustafa Necmi̇ İlhan, Hakan Tüzün, Rahmi̇ Kiliç, Nuran Yildirim
Nonpharmaceutical Interventions In Turkey And Worldwide During Covid-19 Pandemic, Mustafa Necmi̇ İlhan, Hakan Tüzün, Rahmi̇ Kiliç, Nuran Yildirim
Turkish Journal of Medical Sciences
Nonpharmaceutical interventions (NPIs) are actions apart from getting vaccinated and medications, in order to promote deceleration of the spread of illness among people and communities during pandemic. In this article, we aim to examine NPIs applied in Turkey and worldwide due to the COVID-19 pandemic. Some of the NPIs such as isolation, quarantine, and contact tracing were maintained with updates of the Ministry of Health guidelines in Turkey. Some NPIs including travel and partial or full curfew mobilization restrictions were set in accordance with the various periods by the number of cases. Periods of restrictions at autumn 2021 to summer …
Current Infection Prevention And Control Strategies Of Covid-19 In Hospitals, Gamze Kalin Ünüvar, Mehmet Doğanay, Emi̇ne Alp
Current Infection Prevention And Control Strategies Of Covid-19 In Hospitals, Gamze Kalin Ünüvar, Mehmet Doğanay, Emi̇ne Alp
Turkish Journal of Medical Sciences
Background/aim: Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has been appeared first in China since December 2019. Transmission of SARS-CoV-2 occurs primarily with droplets through coughing and sneezing and also occurs through inhalation of aerosolized secretions, which travel, remain suspended in the air longer. Materials and methods: Since early stages of the outbreak, COVID-19 cases have been described in healthcare workers (HCWs). However, in the early stages, the disease may be asymptomatic. This may lead to incorrect diagnosis or delayed diagnosis and may lead to the nosocomial spread of the virus. One of the …
Pandemic Hospitals And Reorganizing Emergency Departments, Afşi̇n Emre Kayipmaz, Ahmet Demi̇rcan
Pandemic Hospitals And Reorganizing Emergency Departments, Afşi̇n Emre Kayipmaz, Ahmet Demi̇rcan
Turkish Journal of Medical Sciences
Emergency departments have always been the first point of contact for hospitals in many situations, including man-made and natural disasters. The first places where patients with symptoms of COVID-19 were met in health institutions were also emergency departments. Emergency departments play an important role in diagnosing the disease and isolating patients (by hospitalization if necessary). The process, which starts with the triage of outpatients admitted to the emergency department and brought by ambulance, continues as isolation of the patients in appropriate areas including physical evaluation, management of laboratory and scanning processes and, if necessary, providing cardiopulmonary resuscitation with airway support. …
Evaluating The Efficiency Of Public Policy Measures Against Covid-19, Hati̇ce Rahmet Güner, İmran Hasanoğlu, Fi̇rdevs Aktaş
Evaluating The Efficiency Of Public Policy Measures Against Covid-19, Hati̇ce Rahmet Güner, İmran Hasanoğlu, Fi̇rdevs Aktaş
Turkish Journal of Medical Sciences
The World Health Organization (WHO) declared COVID-19 as a Public Health Emergency of international concern on January 30, 2020, and a pandemic on March 11, 2020. Afterward, it spread rapidly all over the world, causing almost 4 million deaths as of June 2021. It is clear that effective preventive measures are needed in this devastating disease, which still has no cure. In addition to mask using, social distancing, and hygiene practices, which enter our lives as the most basic precautions, communities aim to reduce the effects of the COVID-19 pandemic. All over the world, the measures taken and activities performed …
How Efficient Are Facial Masks Against Covid-19? Evaluating The Mask Use Of Variouscommunities One Year Into The Pandemic, Aslıhan Candevi̇r, Cem Üngör, Fi̇gen Çi̇zmeci̇ Şenel, Yeşi̇m Taşova
How Efficient Are Facial Masks Against Covid-19? Evaluating The Mask Use Of Variouscommunities One Year Into The Pandemic, Aslıhan Candevi̇r, Cem Üngör, Fi̇gen Çi̇zmeci̇ Şenel, Yeşi̇m Taşova
Turkish Journal of Medical Sciences
Face masks are devices worn over the mouth and nose to protect against splashes, infectious respiratory droplets, or aerosols generated during breathing or coughing according to their filtering capacity. Medical masks, respirators, or cloth masks have been used for source control and for the protection of the exposed. After the first case on March 11, 2020, in Turkey, National COVID-19 Scientific Advisory Board published various contents for the correct use of masks. Medical face masks have been used in healthcare settings for both source control and potential personal protection before the COVID-19 pandemic. Adverse events associated with using masks are …
Rna-Based Covid-19 Vaccine Candidates With Clinical Phase Trials In Progress, Leyla İpek Rudvan Al, Meli̇ha Çağla Sönmezer, Serhat Ünal
Rna-Based Covid-19 Vaccine Candidates With Clinical Phase Trials In Progress, Leyla İpek Rudvan Al, Meli̇ha Çağla Sönmezer, Serhat Ünal
Turkish Journal of Medical Sciences
Due to the COVID-19 infection, which was recognized as a global pandemic by the WHO on March 11, 2020, the number of cases and disease-related deaths increases day by day globally. For this reason, antiviral agents used in treatment and vaccines, the most effective weapon in prevention, continue to be the most popular topic of the plan. Several situations are expected to affect the course of the pandemic. The loss of the ability of the virus to mutate and cause disease, the fact that those who become immunized by having the disease in the society reach a critical rate and …
Cerebral Hemodynamic Alterations In Patients With Covid-19, Ali̇ Riza Sonkaya, Bi̇lgi̇n Öztürk, Ömer Karadaş
Cerebral Hemodynamic Alterations In Patients With Covid-19, Ali̇ Riza Sonkaya, Bi̇lgi̇n Öztürk, Ömer Karadaş
Turkish Journal of Medical Sciences
Background/aim: Coronavirus 2019 disease (Covid-19) was first seen in December 2019 and afterwards it became pandemic. Several systemic involvements have been reported in Covid-19 patients. In this study, it was aimed to investigate the cerebrovascular hemodynamics in patients with Covid-19. Materials and methods: The sample of this study included 20 patients hospitalized in our clinic diagnosed with Covid-19 via PCR modality and 20 healthy volunteers of similar age and sex. Bilateral middle cerebral arteries were investigated with transcranial Doppler ultrasonography. Basal cerebral blood flow velocities and vasomotor reactivity rates were determined and statistically compared. Results: When patient and control groups …
Characteristics And Outcomes Of Critically Ill Patients With Covid-19 In Sakarya, Turkey: Asingle Centre Cohort Study, Havva Kocayi̇ği̇t, Kezban Özmen Süner, Yakup Tomak, Gürkan Demi̇r, İbrahi̇m Kocayi̇ği̇t, Selçuk Yaylaci, Yusuf Aydemi̇r, Mehmet Köroğlu, Oğuz Karabay, Mehmet Hali̇l Öztürk, Ali̇ Fuat Erdem
Characteristics And Outcomes Of Critically Ill Patients With Covid-19 In Sakarya, Turkey: Asingle Centre Cohort Study, Havva Kocayi̇ği̇t, Kezban Özmen Süner, Yakup Tomak, Gürkan Demi̇r, İbrahi̇m Kocayi̇ği̇t, Selçuk Yaylaci, Yusuf Aydemi̇r, Mehmet Köroğlu, Oğuz Karabay, Mehmet Hali̇l Öztürk, Ali̇ Fuat Erdem
Turkish Journal of Medical Sciences
Background/aim: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Turkey on March 10, 2020 and the number of the patients are increasing day by day. Coronavirus disease 2019 (Covid-19) has high mortality rates in intensive care units (ICUs). We aimed to describe the demographic characteristics, comorbidities, treatment protocols, and clinical outcomes among the critically ill patients admitted to the ICU of our hospital. Materials and methods: This cohort study included 103 consecutive patients who had laboratory confirmed Covid-19 and admitted to ICU of Sakarya University Training and Research Hospital between March 19 and April 13, 2020. The …
The Predictive And Diagnostic Accuracy Of Long Pentraxin-3 In Covid-19 Pneumonia, Ahmed Bi̇lal Genç, Selçuk Yaylaci, Hamad Dhei̇r, Ahmed Ci̇had Genç, Kubi̇lay İşsever, Deni̇z Çeki̇ç, Havva Kocayi̇ği̇t, Erdem Çokluk, Alper Karacan, Mehmet Ramazan Şekeroğlu, Hande Toptan, Ertuğrul Güçlü
The Predictive And Diagnostic Accuracy Of Long Pentraxin-3 In Covid-19 Pneumonia, Ahmed Bi̇lal Genç, Selçuk Yaylaci, Hamad Dhei̇r, Ahmed Ci̇had Genç, Kubi̇lay İşsever, Deni̇z Çeki̇ç, Havva Kocayi̇ği̇t, Erdem Çokluk, Alper Karacan, Mehmet Ramazan Şekeroğlu, Hande Toptan, Ertuğrul Güçlü
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study is to evaluate serum pentraxin-3 (PTX-3) levels in Sars-CoV-2 virus infection (COVID-19) patients and to investigate whether PTX-3 predicts the disease prognosis. Materials and methods: This study was conducted on 88 confirmed COVID-19 patients who were hospitalized due to symptomatic pneumonia between April 15 and August 15, 2020. The patients were divided into two groups as survived patients and non-survived patients. Both groups were compared according to demographic features, comorbid conditions and measurement of the PTX-3 and other laboratory parameters of the patients. Results: Of 88 patients with COVID-19, 59 (67%) were discharged with …
Factors Affecting Mortality In Geriatric Patients Hospitalized With Covid-19, Rabi̇a Bağ Soytaş, Damla Ünal, Pinar Arman, Veysel Suzan, Tuğçe Emi̇roğlu Gedi̇k, Günay Can, Bora Korkmazer, Ridvan Karaali̇, Şermi̇n Börekçi̇, Mert Ahmet Kuşkucu, Hakan Yavuzer, Ülev Deni̇z Erdi̇nçler, Alper Döventaş
Factors Affecting Mortality In Geriatric Patients Hospitalized With Covid-19, Rabi̇a Bağ Soytaş, Damla Ünal, Pinar Arman, Veysel Suzan, Tuğçe Emi̇roğlu Gedi̇k, Günay Can, Bora Korkmazer, Ridvan Karaali̇, Şermi̇n Börekçi̇, Mert Ahmet Kuşkucu, Hakan Yavuzer, Ülev Deni̇z Erdi̇nçler, Alper Döventaş
Turkish Journal of Medical Sciences
Background/aim: We aimed to investigate the factors affecting the mortality of patients aged 65 years or older who were hospitalized with the diagnosis of new coronavirus pneumonia (COVID-19). Materials and methods: This is a retrospective study of patients 65 years old or older with COVID-19 who were hospitalized in İstanbul University-Cerrahpaşa, Cerrahpaşa Medical Faculty Hospital, between March 11 and May 28, 2020. Demographic, clinical, treatment, and laboratory data were extracted from electronic medical records. We used univariate and multivariate logistic regression methods to explore the risk factors for in-hospital death. Results: A total of 218 patients (112 men, 106 women) …
The Necessity Of Treating Asymptomatic Bacteriuria With Antibiotics In The Perioperativeperiod Of Joint Arthroplasty: A Metaanalysis., Sayed Abdulla Jami, Jian Dang Shi, Zhanwen Zhou, Chang Hao Liu
The Necessity Of Treating Asymptomatic Bacteriuria With Antibiotics In The Perioperativeperiod Of Joint Arthroplasty: A Metaanalysis., Sayed Abdulla Jami, Jian Dang Shi, Zhanwen Zhou, Chang Hao Liu
Turkish Journal of Medical Sciences
Background/aim: Oral antibiotics are usually used to treat asymptomatic bacteriuria during the perioperative period of joint replacement. However, there is no unified conclusion as to whether asymptomatic bacteriuria causes infection around joint prostheses, and the efficacy of antibiotics is unknown. Materials and methods: We systematically searched PubMed, CNKI, Ovid, Cochrane Library, EMBASE, manual research, and references of relevant articles up to January 1, 2020, to identify and compare observational studies. The Cochrane systematic review method was used, and Review Manager 5.3 software was used for analysis. Results: Nine articles were included in the analysis, involving 29,844 cases of joint arthroplasty …
Sural Nerve Harvest For Infants: Integrated With Information Based On Anatomicaldissections, Mustafa Büyükmumcu, Anil Di̇dem Aydin Kabakçi, Duygu Akin Saygin, Mehmet Tuğrul Yilmaz, Muzaffer Şeker
Sural Nerve Harvest For Infants: Integrated With Information Based On Anatomicaldissections, Mustafa Büyükmumcu, Anil Di̇dem Aydin Kabakçi, Duygu Akin Saygin, Mehmet Tuğrul Yilmaz, Muzaffer Şeker
Turkish Journal of Medical Sciences
Background/aim: The aim of the present study was to determine the course and possible variations of the sural nerve with all anatomical details in human fetal cadavers. Materials and methods: This study was performed on 60 fetal cadavers. Formation type and level of the sural nerve was detected. Results: According to trimesters, it was determined that the mean transverse and vertical distance between the lowest point of the LM and the SN varied between 1.1 and 2.9 mm and 1.54 and 3.58 mm, respectively. Type 2 was the most common seen type of sural nerve (35.83%). It was determined that …
Retrospective Analysis Of The Effect Of Breast Surgery On Body Posture In Patients Withearly-Stage Breast Cancer After Cancer Treatment (Venus Study)(Breast Cancer And Body Posture), Özgür Tanriverdi̇, Ahmet Ozan Çeti̇n, Ali̇ Alkan
Retrospective Analysis Of The Effect Of Breast Surgery On Body Posture In Patients Withearly-Stage Breast Cancer After Cancer Treatment (Venus Study)(Breast Cancer And Body Posture), Özgür Tanriverdi̇, Ahmet Ozan Çeti̇n, Ali̇ Alkan
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to determine whether breast surgery changes body posture in patients with early-stage breast cancer. Materials and methods: Study variables include age, side and localization of the tumor in the breast, applied breast surgery, axillary interference, pathological tumor size, axillary lymph node metastasis, body mass index, bone density, adjuvant therapies, and histological type. Thoracic kyphosis angle due to the anatomically affected primary region to detect changes in body posture and Cobb's method were used to measure this. Results: There was a statistically significant difference in the mean Cobb's angle between the follow-up times of …
Pain During Walking And Ascending Stairs Before Hyaluronic Acid Injection Was Commonin Patients With Knee Osteoarthritis: A Qualitative Study, Ömer Özkan, Nai̇la Babayeva, Şeri̇fe Şeyma Torğutalp, Ömer Serkan Kara, Gürhan Dönmez, Feza Korkusuz
Pain During Walking And Ascending Stairs Before Hyaluronic Acid Injection Was Commonin Patients With Knee Osteoarthritis: A Qualitative Study, Ömer Özkan, Nai̇la Babayeva, Şeri̇fe Şeyma Torğutalp, Ömer Serkan Kara, Gürhan Dönmez, Feza Korkusuz
Turkish Journal of Medical Sciences
Background/aim: Knee osteoarthritis (OA) is a common pathology characterized by degeneration of the articular cartilage. The aim of the research was to ask patients how they decided to make the injection, what treatments they received, their complaints prior to and after the injection and how they feel at the moment, and whether they are currently exercising or not. Thus, to demonstrate the patients' outcomes with their own expression. Materials and methods: A total of 92 knee OA patients completed semistructured interviews, which included six open-ended questions. Results: A total of 92 patients (66 female, 26 male) aged between 36 and …
Can Preoperative Modified Systemic Inflammation Score (Msis) Be Used To Predictmalignancy In Persistent Nondiagnostic Thyroid Nodules?, Hakan Ataş, Bi̇rol Korukluoğlu, Bülent Çomçali, Neşe Yakşi̇, Bariş Saylam, Mesut Tez
Can Preoperative Modified Systemic Inflammation Score (Msis) Be Used To Predictmalignancy In Persistent Nondiagnostic Thyroid Nodules?, Hakan Ataş, Bi̇rol Korukluoğlu, Bülent Çomçali, Neşe Yakşi̇, Bariş Saylam, Mesut Tez
Turkish Journal of Medical Sciences
Background/aim: Despite the use of ultrasound guidance, a significant part of thyroid biopsies are nondiagnostic (ND). We aimed to investigate the utility of the preoperative modified systemic inflammation score (mSIS) to predict malignancies in patients with persistent ND thyroid nodules (TNs). Materials and methods: Records of 924 patients underwent thyroidectomy between September 2016 and May 2019 were retrospectively reviewed. The calculation of mSIS was as follows: mSIS 0 [patients with albumin (ALB) ≥ 4.0 g/dL and lymphocyte to monocyte ratio (LMR) ≥ 3.4], mSIS 1 [ALB < 4.0 g/dL or LMR < 3.4], and mSIS 2 [ALB < 4.0 g/dL and LMR < 3.4]. Results: One hundred and thirty-six patients were included in the study. Of the patients with a median age of 49 (21-81) years, 26 (19.1%) were male, and 110 (80.9%) were female. Besides low lymphocyte count (P = 0.03), and ALB levels (P < 0.01), higher BMI (P = 0.02) were also associated with malignancy. In patients classified as mSIS 2, 1 and 0; malignancy rates were 100%, 25.8%, and 16.1%, respectively. The association between preoperative mSIS and thyroid malignancies was statistically significant (P < 0.01). Conclusion: We recommend that when patients with persistent ND TNs are assigned to mSIS 2 or 1, surgery should not be delayed due to the risk of malignancy.
Acute Necrotizing Encephalopathy Of Childhood: A Single-Center Experience, Erhan Aksoy, Ülkühan Öztoprak, Hali̇l Çeli̇k, Fati̇h Mehmet Aki̇f Özdemi̇r, Mehbare Özkan, Hülya Kayilioğlu, Ayşegül Daniş, Özge Kucur, Selman Kesi̇ci̇, Mutlu Uysal Yazici, Ebru Azapağasi, Yasemi̇n Taşci Yildiz, Nesri̇n Ceylan, Sali̇ha Şenel, Deni̇z Yüksel
Acute Necrotizing Encephalopathy Of Childhood: A Single-Center Experience, Erhan Aksoy, Ülkühan Öztoprak, Hali̇l Çeli̇k, Fati̇h Mehmet Aki̇f Özdemi̇r, Mehbare Özkan, Hülya Kayilioğlu, Ayşegül Daniş, Özge Kucur, Selman Kesi̇ci̇, Mutlu Uysal Yazici, Ebru Azapağasi, Yasemi̇n Taşci Yildiz, Nesri̇n Ceylan, Sali̇ha Şenel, Deni̇z Yüksel
Turkish Journal of Medical Sciences
Background/aim: Acute necrotizing encephalopathy is a rare type of acute encephalopathy characterized by multi-ocal brain lesions and associated severe neurological findings and various organ dysfunctions may accompany it. Materials and Methods: Patients with acute necrotizing encephalopathy of childhood diagnosed by pediatric neurology and pediatric intensive care at Sami Ulus Maternity, Child Health and Diseases Training and Research Hospital between 2007 and 2020 were included in this study. Results: Nine patients (six females, three males) with a mean age of 4.05 ± 1.94 years (age range 1-6.5) were included in this study. The interval range between fever and encephalopathy in patients …
Umbilical Cord Levels Of Macrophage Migration Inhibitory Factor In Neonatal Respiratorydistress Syndrome, Süleyman Bayraktar, Bi̇lge Bayraktar, Ülkan Kiliç
Umbilical Cord Levels Of Macrophage Migration Inhibitory Factor In Neonatal Respiratorydistress Syndrome, Süleyman Bayraktar, Bi̇lge Bayraktar, Ülkan Kiliç
Turkish Journal of Medical Sciences
Background/aim: We aimed to evaluate the association of the umbilical cord macrophage migration inhibitory factor (MIF) with the respiratory distress syndrome (RDS) in preterm infants. Materials and methods: A total of eighty six preterm infants (38 with RDS and 48 without RDS) were involved in the study. ELISA is the technique assaying MIF values. Results: The mean of the infants' gestational ages and birth weights were significantly different (P = 0.0001). There were no significant differences in sex, delivery mode or exposure to antenatal steroid among the groups (P > 0.05). Umbilical cord MIF levels of the infants were not correlated …
Does Treatment With Sodium-Glucose Co-Transporter-2 Inhibitors Have An Effect On Sleepquality, Quality Of Life, And Anxiety Levels In People With Type 2 Diabetes Mellitus?, Serdar Şahi̇n, Özlem Hali̇loğlu, Özge Polat Korkmaz, Emre Durcan, Hümeyra Rekali Şahi̇n, Volkan Demi̇rhan Yumuk, Taner Damci, Hasan Mahmut İlkova, Zeynep Oşar Si̇va
Does Treatment With Sodium-Glucose Co-Transporter-2 Inhibitors Have An Effect On Sleepquality, Quality Of Life, And Anxiety Levels In People With Type 2 Diabetes Mellitus?, Serdar Şahi̇n, Özlem Hali̇loğlu, Özge Polat Korkmaz, Emre Durcan, Hümeyra Rekali Şahi̇n, Volkan Demi̇rhan Yumuk, Taner Damci, Hasan Mahmut İlkova, Zeynep Oşar Si̇va
Turkish Journal of Medical Sciences
Background/aim: To evaluate the impact of treatment with sodium-glucose co-transporter-2 (SGLT2) Inhibitors on quality of life (QoL), sleep quality (SQ), and anxiety levels in patients with Type 2 diabetes mellitus (T2DM). Materials and methods: Ninety-seven patients with type 2 diabetes admitted to tertiary care hospital diabetes clinic were included. Fifty patients were randomized to receive SGLT2 inhibitors in addition to baseline treatment (Group A), 47 subjects continued with their baseline treatment or were added other medications as needed (Group B). Thirty healthy controls (HC) were recruited (Group C). All groups were subjected to the Turkish version of Short Form-36 (SF-36), …
Dynamic Thiol/Disulfide Homeostasis As Oxidative Stress Marker In Diabetic Ketoacidosis, Yavuz Otal, Fati̇h Ahmet Kahraman, Fadi̇me Güllü Haydar, Özcan Erel
Dynamic Thiol/Disulfide Homeostasis As Oxidative Stress Marker In Diabetic Ketoacidosis, Yavuz Otal, Fati̇h Ahmet Kahraman, Fadi̇me Güllü Haydar, Özcan Erel
Turkish Journal of Medical Sciences
Background/aim: The aim of present study was to investigate the dynamic thiol/disulfide homeostasis as oxidative stress marker in diabetic ketoacidosis (DKA). Materials and methods: A total of 77 participants consisting of 32 patients with DKA and 45 healthy volunteers were included in the study. Thiol/disulfide homeostasis (TDH) [total thiol-native thiol/disulfide changes] were measured in both groups (patient group and control group) using a brand new method developed by Erel and Neselioglu. Half of the difference between total thiol and native thiol concentrations gives the amount of disulfide bond. Results: Total thiol, native thiol, and disulfide levels in blood were found …
Achievements Of The Covid-19 Turkey Platform In Vaccine And Drug Development Withan Approach Of "Co-Creation And Succeeding Together", Hasan Mandal
Turkish Journal of Medical Sciences
Mobilizing the research ecosystem for accelerating vaccine and drug development has been an important reality of the pandemic. This article reviews the scientific advances that are attained by the COVID-19 Turkey Platform for vaccine and drug development against the SARS-CoV-2 virus. The platform that is coordinated by the Scientific and Technological Research Council of Turkey is established with a "co-creation and succeeding together" approach, which involves 436 researchers across 49 different institutions working on 17 vaccine and drug development projects in total. Recent advances of the COVID-19 Turkey Platform include the fourth virus-like particle-based vaccine candidate in the world to …
Turkey's Response To Covid-19 Pandemic: Strategy And Key Actions, Gülşen Barlas, Harun Öztürk, Gülen Pehli̇vantürk, Sabahatti̇n Aydin
Turkey's Response To Covid-19 Pandemic: Strategy And Key Actions, Gülşen Barlas, Harun Öztürk, Gülen Pehli̇vantürk, Sabahatti̇n Aydin
Turkish Journal of Medical Sciences
COVID-19 emerged at the end of 2019 in Wuhan, China, and spread rapidly around the world causing many deaths. Due to the intercontinental escalation in the epidemic, while WHO declared a pandemic on March 11, 2020, our country's first case was diagnosed. Before this, the MoH established the Operations Center against possible risks regarding the Pandemic Influenza Preparedness Plan on January 10, 2020 and formed the Scientific Committee, which has a critical importance in epidemic management. National and Provincial Pandemic Coordination Boards were established within the scope of this plan. Fast, effective and frequently updated decisions were implemented. The epidemic …
One And A Half Years Into The Covid-19 Pandemic - Exit Strategies And Efficacy Of Sarscov-2 Vaccines For Holistic Management And Achieving Global Control, Eskild Petersen, Ayşe Deni̇z Gökengi̇n, Asma Al Balushi, Alimuddin Zumla
One And A Half Years Into The Covid-19 Pandemic - Exit Strategies And Efficacy Of Sarscov-2 Vaccines For Holistic Management And Achieving Global Control, Eskild Petersen, Ayşe Deni̇z Gökengi̇n, Asma Al Balushi, Alimuddin Zumla
Turkish Journal of Medical Sciences
One and a half years into the pandemic, SARS-CoV-2 is still here to stay. Whilst rapid several effective COVID-19 vaccines have been developed and are being rolled out, the critical questions remain whether vaccines provide widespread protection against infection and reinfection, and what the duration of protection is. Community wide control cannot be obtained until almost everyone is immune. Vaccine production must be ramped up to cover the world population. The price of herd immunity through natural infection is high mortality in the elderly and morbidity in other age groups including children and Long-COVID. We must expect a new wave …