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Articles 601 - 630 of 4871
Full-Text Articles in Medicine and Health Sciences
The Reliability And Validity Of The Turkish Version Of The Self-Administered Neck Mobility Assessment Tool (S-Rom-Neck) In Patients With Chronic Neck Pain, Fati̇h Özden, Emi̇ne Aslan Telci̇, Serbay Şekeröz, Nuray Akkaya
The Reliability And Validity Of The Turkish Version Of The Self-Administered Neck Mobility Assessment Tool (S-Rom-Neck) In Patients With Chronic Neck Pain, Fati̇h Özden, Emi̇ne Aslan Telci̇, Serbay Şekeröz, Nuray Akkaya
Turkish Journal of Medical Sciences
Background/aim: The self-administered neck mobility assessment tool (S-ROM-Neck) is the subjective cervical region range of motion (S-ROM) assessment scale. The study aimed to demonstrate the reliability and validity of the Turkish version of the S-ROM-Neck in patients with chronic neck pain. Materials and methods: A cross-sectional study was conducted with a total of 60 chronic neck pain patients in the Physical Therapy and Rehabilitation Clinic of Pamukkale University Hospital between January and August 2021. The mean age of the individuals was 34.1 ± 9.9 years. Patients were assessed with S-ROM-Neck twice to prove the test-retest reliability. In addition, Visual Analogue …
Nutritional Risks In Children With Food Allergy, Zeynep Parlak, Deni̇z İlgün Gürel, Özge Uysal Soyer, Bülent Eni̇s Şekerel, Ümi̇t Murat Şahi̇ner
Nutritional Risks In Children With Food Allergy, Zeynep Parlak, Deni̇z İlgün Gürel, Özge Uysal Soyer, Bülent Eni̇s Şekerel, Ümi̇t Murat Şahi̇ner
Turkish Journal of Medical Sciences
Abstract: Food allergies (FA) are a growing problem in the pediatric population and clinical features differ according to the underlying immunological mechanisms. While the primary management strategy is to eliminate the culprit food from the diet, assessment of the potential nutritional risks of elimination is also an integral part of management. In cases that do not improve over time; if you have basic food allergies and multiple food allergies, this can also lead to negative nutritional consequences. The contribution of basic nutrients, economical and easily accessible foods to the diet, is critical and has an important place in meeting the …
Crm1 Expression: Association With High Prognostic Value In Laryngeal Cancer, Tali̇h Özdaş, Si̇bel Özdaş, İpek Canatar, Erdal Coşgun, Eli̇f Burcu Şenyurt, Orhan Görgülü
Crm1 Expression: Association With High Prognostic Value In Laryngeal Cancer, Tali̇h Özdaş, Si̇bel Özdaş, İpek Canatar, Erdal Coşgun, Eli̇f Burcu Şenyurt, Orhan Görgülü
Turkish Journal of Medical Sciences
Background/aim: Laryngeal cancer is a very common malignant tumor of the head and neck. While laryngeal cancer does not show any obvious early symptoms, it tends to have a poor prognosis in advanced clinical stages. Chromosome region maintenance 1 (CRM1) mediates the nuclear export of some RNAs, major and tumor suppressor proteins and has been associated with the pathogenesis of many tumors. However, the clinicopathological significance of CRM1 gene expression in laryngeal cancer has not been clarified yet. Therefore, this study aims to detect the expression of CRM1 in laryngeal cancer and to investigate its relationship with clinicopathological parameters and …
Curcumin Promotes Skin Wound Healing By Activating Nrf2 Signaling Pathways And Inducing Apoptosis In Mice, Junli Wu, Li Deng, Ling Yin, Zhirong Mao, Xiaoqing Gao
Curcumin Promotes Skin Wound Healing By Activating Nrf2 Signaling Pathways And Inducing Apoptosis In Mice, Junli Wu, Li Deng, Ling Yin, Zhirong Mao, Xiaoqing Gao
Turkish Journal of Medical Sciences
Background/aim: Curcumin may have potential as a therapy for wound healing, but the underlying mechanism remains unclear. It is not known whether curcumin can promote wound healing by activating Nrf2 signaling pathway and inducing apoptosis. This study determined the role of Nrf2 signaling pathway and apoptosis in curcumin-promoting skin wound healing. Materials and methods: The full-thickness skin defect model of mice was made and randomly divided into a control group and a curcumin group. The mice in the curcumin group and in the control group received respectively a daily topical treatment of Vaseline cream with or without 5 mg curcumin. …
Microstructural Evaluation Of The Brain With Advanced Magnetic Resonance Imaging Techniques In Cases Of Electrical Status Epilepticus During Sleep (Eses), Hani̇fe Gülden Düzkalir, Bariş Genç, Safi̇ye Güneş Sağer, Ayberk Türkyilmaz, Hedi̇ye Pinar Günbey
Microstructural Evaluation Of The Brain With Advanced Magnetic Resonance Imaging Techniques In Cases Of Electrical Status Epilepticus During Sleep (Eses), Hani̇fe Gülden Düzkalir, Bariş Genç, Safi̇ye Güneş Sağer, Ayberk Türkyilmaz, Hedi̇ye Pinar Günbey
Turkish Journal of Medical Sciences
Background/aim: The cause and treatment of electrical status epilepticus during sleep (ESES), one of the epileptic encephalopathies of childhood, is unclear. The aim of this study was to evaluate possible microstructural abnormalities in the brain using advanced magnetic resonance imaging (MRI) techniques in ESES patients with and without genetic mutations. Materials and methods: This research comprised 12 ESES patients without structural thalamic lesions (6 with genetic abnormalities and 6 without) and 12 healthy children. Whole-exome sequencing was used for the genetic mutation analysis. Brain MRI data were evaluated using tractus-based spatial statistics, voxel-based morphometry, a local gyrification index, subcortical shape …
Exosome-Mediated Long Noncoding Rna (Lncrna) Part1 Suppresses Malignant Progression Of Oral Squamous Cell Carcinoma Via Mir-17-5p/Socs6 Axis, Yuheng Du, Yanjie Shuai, Hongling Wang, Huisheng Li, Yajing Li
Exosome-Mediated Long Noncoding Rna (Lncrna) Part1 Suppresses Malignant Progression Of Oral Squamous Cell Carcinoma Via Mir-17-5p/Socs6 Axis, Yuheng Du, Yanjie Shuai, Hongling Wang, Huisheng Li, Yajing Li
Turkish Journal of Medical Sciences
Background/aim: Exosomes derived from oral squamous cell carcinoma (OSCC) could modulate OSCC development. This study aimed to explore effects of exosome-mediated lncRNA PART1 on OSCC cells. Materials and methods: This study was performed in Tianjin Medical University Cancer Institute from February 2021 to March 2022. Bioinformatic analysis was performed on the public database GEPIA (http://gepia.cancer-pku.cn/). Exosomes isolated from cell lines squamous cell carcinoma 9 (SCC9) and Centre Antoine Lacassagne-27 (CAL27) were identified by transmission electron microscope and western blot. Exosome-mediated lncRNA PART1, microRNA-17-5p(miR-17-5p) and suppressor of cytokine signaling 6(SOCS6) RNA expressions were assessed by quantitative reverse transcription polymerase chain reaction …
Does Apocynin Increase Liver Regeneration In The Partial Hepatectomy Model?, Yilmaz Bi̇lgi̇ç, Burhan Hakan Kanat, Onural Özhan, Azi̇be Yildiz, Zeynep Aksungur, Mehmet Erman Erdemli̇, Ni̇gar Vardi, Yusuf Türköz, Ahmet Sami̇ Akbulut, Adem Köse, Hakan Parlakpinar
Does Apocynin Increase Liver Regeneration In The Partial Hepatectomy Model?, Yilmaz Bi̇lgi̇ç, Burhan Hakan Kanat, Onural Özhan, Azi̇be Yildiz, Zeynep Aksungur, Mehmet Erman Erdemli̇, Ni̇gar Vardi, Yusuf Türköz, Ahmet Sami̇ Akbulut, Adem Köse, Hakan Parlakpinar
Turkish Journal of Medical Sciences
Background/aim: Hepayocyte loss may develop secondary to liver surgery and at this point liver regeneration plays a significant act in terms of liver reserve. The purpose of this research was to investigate the efficacy of apocynin on liver regeneration and preservation after partial hepatectomy in rats. Materials and methods: A total of 32 rats, have been divided into 4 groups (n: 8) for hepatectomy model. Inflammatory and antiinflammatory parameters were measured from blood and liver tissue samples. In addition, the effects of apocynin were examined immunohistochemically and histopathologically from liver tissue. Results: In liver tissue samples, a significant difference has …
Investigation Of Igf-1, Igf-Bp3 And Igf-Bp5 Levels In Umbilical Cord Blood Of Infants With Developmental Dysplasia Of The Hip, Esra Demi̇rel, Eyüp Şenocak, Gamze Nur Ci̇mi̇lli̇ Şenocak, Ali̇ Şahi̇n, Berri̇n Göktuğ Kadioğlu, Özlem Gündüz
Investigation Of Igf-1, Igf-Bp3 And Igf-Bp5 Levels In Umbilical Cord Blood Of Infants With Developmental Dysplasia Of The Hip, Esra Demi̇rel, Eyüp Şenocak, Gamze Nur Ci̇mi̇lli̇ Şenocak, Ali̇ Şahi̇n, Berri̇n Göktuğ Kadioğlu, Özlem Gündüz
Turkish Journal of Medical Sciences
Background/aim: IGF-1 (insulin-like growth factor-1) is an important regulator of bone formation. Its deficiency has been associated with fetal growth disorders and hip dysplasia. The aim of this study was to evaluate whether IGF-1, IGF-BP3 (insulin like growth factorbinding protein 3), and IGF-BP5 levels in the umbilical cord blood can be predictive for early diagnosis of DDH. Materials and methods: Umbilical cord blood samples were collected from 860 mothers with pregnancies at high risk for DDH between October 2020 and January 2021. Mothers at 37-42 weeks of gestation, with risk factors for DDH, who delivered healthy infants were included. Blood …
Investigation Of The Value Of Hematological Biomarkers In The Clinical Differential Diagnosis Of Igg4-Rd, Hazan Karadeni̇z, Aslihan Avanoğlu Güler, Riza Can Kardaş, Muzaffer Karadeni̇z, Hati̇ce Paşaoğlu, Hami̇t Küçük, Berna Göker, Abdurrahman Tufan, Mehmet Aki̇f Öztürk
Investigation Of The Value Of Hematological Biomarkers In The Clinical Differential Diagnosis Of Igg4-Rd, Hazan Karadeni̇z, Aslihan Avanoğlu Güler, Riza Can Kardaş, Muzaffer Karadeni̇z, Hati̇ce Paşaoğlu, Hami̇t Küçük, Berna Göker, Abdurrahman Tufan, Mehmet Aki̇f Öztürk
Turkish Journal of Medical Sciences
Background/aim: IgG4- related disease (IgG4- RD) is a systemic fibroinflammatory disease whose pathogenesis has not been completely elucidated. Due to the novelty and complexity of the diagnostic criteria, it is difficult to distinguish from the diseases included in the differential diagnosis without tissue biopsy. This study aimed to discover new biomarkers that can help for disease diagnosis and its differential diagnosis by reviewing the relationships between neutrophil-lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI). Materials and methods: Thirty IgG4- RD, 38 granulomatous polyangiitis (GPA), and 46 sarcoidosis patients presenting to the …
What Is The Impact Of Inflammasome Mechanisms On Male Infertility?, Eser Ördek, Bülent Kati, İsmai̇l Koyuncu, Mehmet Demi̇r, İsmai̇l Yağmur, Eyyup Sabri̇ Peli̇t, Hali̇l Çi̇ftçi̇, Ercan Yeni̇
What Is The Impact Of Inflammasome Mechanisms On Male Infertility?, Eser Ördek, Bülent Kati, İsmai̇l Koyuncu, Mehmet Demi̇r, İsmai̇l Yağmur, Eyyup Sabri̇ Peli̇t, Hali̇l Çi̇ftçi̇, Ercan Yeni̇
Turkish Journal of Medical Sciences
Background/aim: Mechanisms to explain inflammation in male infertility of unknown cause are still being investigated. The inflammasome is a key regulator of innate immunity in the inflammatory response to infections. Our study aims to investigate the effects of varicocele on infertility, its relationship with antioxidant and inflammasome mechanisms, and how it could be guided in azoospermic or nonazoospermic patients. Materials and methods: A cross-sectional cohort study was conducted at the department of urology in our university hospital. Eightyeight randomly selected men aged 20-45 admitted to our hospital because of infertility between September 2019 and July 2020 were included in the …
The Role Of Superb Microvascular Imaging In Detecting Low-Grade Inflammation Among Adults And Those With Chronic Kidney Disease: A Preliminary Study, Alaaddi̇n Nayman, Nusret Seher, Mehmet Öztürk, Hali̇l Özer, Gülperi̇ Çeli̇k
The Role Of Superb Microvascular Imaging In Detecting Low-Grade Inflammation Among Adults And Those With Chronic Kidney Disease: A Preliminary Study, Alaaddi̇n Nayman, Nusret Seher, Mehmet Öztürk, Hali̇l Özer, Gülperi̇ Çeli̇k
Turkish Journal of Medical Sciences
Background/aim: Pathophysiologic changes associated with chronic inflammation occur with aging and more prominently in patients with chronic kidney disease (CKD), and an association between chronic inflammation and muscle wasting has been identified. The microcirculation is extremely sensitive to the inflammatory process and actively participates in it. In a healthy adult, angiogenesis is a strictly controlled and rare occurrence. However, aberrant angiogenesis and the development of new tiny blood vessels are known in chronic inflammatory diseases. Superb microvascular imaging (SMI) is a noninvasive technique that can evaluate tiny vessels with low blood flow and provide quantitative data. Our goal was to …
Texture Analysis Of Multiparametric Magnetic Resonance Imaging For Differentiating Clinically Significant Prostate Cancer In The Peripheral Zone, Hali̇l Özer, Mustafa Koplay, Ahmet Baytok, Nusret Seher, Lütfi̇ Saltuk Demi̇r, Abi̇di̇n Kilinçer, Mehmet Kaynar, Serdar Göktaş
Texture Analysis Of Multiparametric Magnetic Resonance Imaging For Differentiating Clinically Significant Prostate Cancer In The Peripheral Zone, Hali̇l Özer, Mustafa Koplay, Ahmet Baytok, Nusret Seher, Lütfi̇ Saltuk Demi̇r, Abi̇di̇n Kilinçer, Mehmet Kaynar, Serdar Göktaş
Turkish Journal of Medical Sciences
Background/aim: Texture analysis (TA) provides additional tissue heterogeneity data that may assist in differentiating peripheral zone (PZ) lesions in multiparametric magnetic resonance imaging (mpMRI). This study investigates the role of magnetic resonance imaging texture analysis (MRTA) in detecting clinically significant prostate cancer (csPCa) in the PZ. Materials and methods: This retrospective study included 80 consecutive patients who had an mpMRI and a prostate biopsy for sus- pected prostate cancer. Two radiologists in consensus interpreted mpMRI and performed texture analysis based on their histopathology. The first-, second-, and higher-order texture parameters were extracted from mpMRI and were compared between groups. Univariate …
The Role Of Endobronchial Ultrasonography Elastography In The Diagnosis Of Hilar And Mediastinal Lymph Nodes, Bariş Demi̇rkol, Eli̇f Tanriverdi̇, Şule Gül, Aysu Si̇nem Koç, Eli̇fe Akgün, Aytül Hande Yardimci, Kürşad Nuri̇ Baydi̇li̇, Erdoğan Çeti̇nkaya
The Role Of Endobronchial Ultrasonography Elastography In The Diagnosis Of Hilar And Mediastinal Lymph Nodes, Bariş Demi̇rkol, Eli̇f Tanriverdi̇, Şule Gül, Aysu Si̇nem Koç, Eli̇fe Akgün, Aytül Hande Yardimci, Kürşad Nuri̇ Baydi̇li̇, Erdoğan Çeti̇nkaya
Turkish Journal of Medical Sciences
Background/aim: Endobronchial ultrasonography (EBUS) is a minimally invasive diagnostic tool in the diagnosis of mediastinal lymph nodes (LNs) and has sonographic features. We aimed to investigate the diagnostic accuracy of EBUS elastography, which evaluates tissue compressibility integrated into EBUS, on malignant vs. benign mediastinal-hilar LNs. Materials and methods: A single-center, prospective study was conducted at the University of Health Sciences Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital between 01/10/2019 and 15/11/2019. The features of 219 LNs evaluated by thoracic computed tomography (CT), positron emission tomography (PET)/CT, EBUS sonography and EBUS elastography were recorded. The LNs sampled by …
Effectiveness Of Ultrasonography-Guided Caudal Epidural Steroid Injection Compared To The Fluoroscopic Application, Emrullah Cem Kesi̇lmez, Kasim Zafer Yüksel, Ayşe Azak Bozan, Cengi̇zhan Yavuz
Effectiveness Of Ultrasonography-Guided Caudal Epidural Steroid Injection Compared To The Fluoroscopic Application, Emrullah Cem Kesi̇lmez, Kasim Zafer Yüksel, Ayşe Azak Bozan, Cengi̇zhan Yavuz
Turkish Journal of Medical Sciences
Background/aim: Caudal epidural steroid injection (CESI) has been increasingly used for treating lower back pain. However, there is still significant controversy about the efficacy and safety of different imaging techniques used to guide CESI. In this context, the objective of this study is to compare the efficacies of fluoroscopy- and ultrasonography-guided CESI in patients with chronic lower back pain. Materials and methods: The population of this retrospective, observational study consisted of all consecutive patients who underwent CESI for lower back pain between 2018 and 2020. Of the 371 patients included in the study sample, 192 had undergone fluoroscopy- guided CESI …
Real-Life Outcomes For Oral Disease-Modifying Treatments Of Relapsing-Remitting Multiple Sclerosis Patients: Adherence And Adverse Event Profiles From Marmara University, Ezgi̇ Vural, Esi̇n Engi̇n, Güli̇n Sünter, Kadri̇ye Ağan Yildirim, Di̇lek Günal
Real-Life Outcomes For Oral Disease-Modifying Treatments Of Relapsing-Remitting Multiple Sclerosis Patients: Adherence And Adverse Event Profiles From Marmara University, Ezgi̇ Vural, Esi̇n Engi̇n, Güli̇n Sünter, Kadri̇ye Ağan Yildirim, Di̇lek Günal
Turkish Journal of Medical Sciences
Background/aim: Disease-modifying treatments (DMT) are used to prevent future relapses and disability. High long-term adherence to treatment is important to achieve disease control. This study aims to investigate and compare adherence, adverse event (AE) profiles, and frequencies, main reasons for treatment discontinuation under Teriflunomide (TERI), Dimethyl Fumarate (DMF), and Fingolimod (FNG) for relapsing-remitting MS (RRMS) patients. This study is designed to explore patient-reported experiences in real-life settings. Materials and methods: Patients who were older than 18 years with a definite diagnosis of RRMS and no history of stem-cell transplantation were included. Outpatient clinic data files at the Neurology Department of …
Multidrug Resistance In Pathogens Of Community-Acquired Urinary Tract Infections In Turkey: A Multicentre Prospective Observational Study, İrfan Şencan, Oğuz Karabay, Fatma Aybala Altay, Serap Süzük Yildiz, Hüsni̇ye Şi̇mşek, Meli̇h Gaffar Gözükara, Semanur Kuzi̇, Gülden Eser Karlidağ, Şafak Kaya, Gülnur Kul, Emi̇ne Türkoğlu, Büşra Ergüt Sezer, Nesi̇be Korkmaz, Si̇bel Yildiz Kaya, Merve Sefa Sayar
Multidrug Resistance In Pathogens Of Community-Acquired Urinary Tract Infections In Turkey: A Multicentre Prospective Observational Study, İrfan Şencan, Oğuz Karabay, Fatma Aybala Altay, Serap Süzük Yildiz, Hüsni̇ye Şi̇mşek, Meli̇h Gaffar Gözükara, Semanur Kuzi̇, Gülden Eser Karlidağ, Şafak Kaya, Gülnur Kul, Emi̇ne Türkoğlu, Büşra Ergüt Sezer, Nesi̇be Korkmaz, Si̇bel Yildiz Kaya, Merve Sefa Sayar
Turkish Journal of Medical Sciences
Background/aim: To have country-wide information about multidrug resistance (MDR) in isolates from community-acquired urinary tract infections (CAUTI) of Turkey, in terms of resistance rates and useful options. Materials and methods: We used a geocode standard, nomenclature of territorial units for statistics (NUTS), and a total of 1588 community-acquired isolates of 20 centres from 12 different NUTS regions between March 2019 and March 2020 were analysed. Results: Of the 1588 culture growths, 1269 (79. 9%) were Escherichia coli and 152 (9.6%) were Klebsiella spp. Male sex, advanced age, and having two or more risk factors showed a statistically significant relation with …
Clinical Characteristics And Outcomes Of Continuous Renal Replacement Therapy Performed On Younger Children Weighing Up To 10 Kg, Emrah Gün, Anar Gurbanov, Özlem Saritaş Naki̇p, Ahmet Yöntem, Ayşen Durak Aslan, Edi̇n Botan, Fevzi̇ Kahveci̇, Serhan Özcan, Ebru Azapağasi, Serhat Emeksi̇z, Mutlu Uysal Yazici, Selman Kesi̇ci̇, Özden Özgür Horoz, Ömer Erdeve, Benan Bayrakci̇
Clinical Characteristics And Outcomes Of Continuous Renal Replacement Therapy Performed On Younger Children Weighing Up To 10 Kg, Emrah Gün, Anar Gurbanov, Özlem Saritaş Naki̇p, Ahmet Yöntem, Ayşen Durak Aslan, Edi̇n Botan, Fevzi̇ Kahveci̇, Serhan Özcan, Ebru Azapağasi, Serhat Emeksi̇z, Mutlu Uysal Yazici, Selman Kesi̇ci̇, Özden Özgür Horoz, Ömer Erdeve, Benan Bayrakci̇
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the clinical features, modality, complications, and effecting factors on the survival of children weighing up to 10 kg who received continuous renal replacement therapy (CRRT). Materials and methods: This study was a retrospective observational study conducted in five pediatric intensive care units in tertiary hospitals in Turkey between January 2015 and December 2019. Results: One hundred and forty-one children who underwent CRRT were enrolled in the study. The median age was 6 (range, 2-12) months, and 74 (52.5%) were male. The median weight of the patients was 6 (range, 4-8.35) kg and 52 (36.9%) …
Can Development Of Asthma And Bronchial Hyperreactivity Be Reduced By Subcutaneous Immunotherapy In Adult Patients With Allergic Rhinitis?, Fatma Merve Tepetam, Ci̇han Örçen, Zeynep Ferhan Özşeker, Di̇ldar Duman, Sema Saraç
Can Development Of Asthma And Bronchial Hyperreactivity Be Reduced By Subcutaneous Immunotherapy In Adult Patients With Allergic Rhinitis?, Fatma Merve Tepetam, Ci̇han Örçen, Zeynep Ferhan Özşeker, Di̇ldar Duman, Sema Saraç
Turkish Journal of Medical Sciences
Background/aim: Allergic rhinitis can be associated with bronchial hyperreactivity (BHR) and create an increased risk for allergic asthma development. We aimed to investigate the effects of subcutaneous immunotherapy (SCIT) on BHR and asthma development in adult patients with allergic rhinitis. Material and methods: The retrospective case-control study was carried out between November 2018 and May 2019 in Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital. In this study, data was recorded for patients with a mite and/or grasses/cereals pollen allergy who were tested for BHR before planned SCIT, and who had allergic rhinitis, with or without asthma. The …
Long-Term Efficiency Of Pulmonary Rehabilitation In Patients With Chronic Obstructive Pulmonary Disease, Bronchiectasis, And Asthma: Does It Differ?, Mustafa Engi̇n Şahi̇n, Seher Satar, Pinar Ergün
Long-Term Efficiency Of Pulmonary Rehabilitation In Patients With Chronic Obstructive Pulmonary Disease, Bronchiectasis, And Asthma: Does It Differ?, Mustafa Engi̇n Şahi̇n, Seher Satar, Pinar Ergün
Turkish Journal of Medical Sciences
Background and aim: The long-term effects of pulmonary rehabilitation (PR) and maintenance programs in obstructive pulmonary diseases have not been sufficiently investigated, particularly in diseases other than COPD. This retrospective study aimed to examine the long-term results of individualized comprehensive outpatient pulmonary rehabilitation in patients with obstructive pulmonary disease. Materials and methods: This study is a single-center, retrospective cohort study. Between 2010 and 2019, 269 patients with chronic airway obstruction were treated in our multidisciplinary PR center at a tertiary training and research hospital, and they were divided into three groups based on their diagnosis: COPD, bronchiectasis, and asthma. Patients' …
Pectoralis Muscle Index Might Be A Factor Associated With Frailty In Older Women With Breast Cancer, Muhammet Cemal Kizilarslanoğlu, M. Ali̇ Eryilmaz, Betül Çi̇ğdem Yortanli, İlknur Rahi̇me Ünal, Bariş Can Ünal, Nahi̇de Baran, Ayşegül Altunkeser, Nergi̇s Aksoy
Pectoralis Muscle Index Might Be A Factor Associated With Frailty In Older Women With Breast Cancer, Muhammet Cemal Kizilarslanoğlu, M. Ali̇ Eryilmaz, Betül Çi̇ğdem Yortanli, İlknur Rahi̇me Ünal, Bariş Can Ünal, Nahi̇de Baran, Ayşegül Altunkeser, Nergi̇s Aksoy
Turkish Journal of Medical Sciences
Background/aim: To investigate the possible relationship between pectoralis muscle (PM) measurement and frailty in older women with breast cancer (BC) (preoperatively defined as stage 1, 2, and 3 diseases). Materials and methods: This retrospective, observational study was conducted at Konya Training and Research Hospital between June and December 2020. A total of 102 patients [median age 62.5 years, median follow-up period two years] were included in the study. PM measurements were obtained from thorax computerized tomography (CT). Pectoralis muscle index (PMI) was calculated by dividing the PM area by the height square of the patients (cm2/m2). Pectoralis muscle density (PMD) …
Effects Of Testosterone Treatment On Anal Sphincter Damage Repair In Ovariectomized Rats, İrem Şenyuva, Duygu Baki̇ Acar, Hasan Hüseyi̇n Demi̇rel, Ece Tunç
Effects Of Testosterone Treatment On Anal Sphincter Damage Repair In Ovariectomized Rats, İrem Şenyuva, Duygu Baki̇ Acar, Hasan Hüseyi̇n Demi̇rel, Ece Tunç
Turkish Journal of Medical Sciences
Background/aim: Fecal incontinence (FI) generally occurs with anal sphincter damage caused by vaginal delivery in women, obvious FI can develop in the postmenopausal stage. This pelvic floor dysfunction has no rational medical therapeutic options. We investigated the effect of testosterone treatment on the anal sphincter structure, serum thiol/disulfide levels, uterine tissue, and body composition in female rats in an experimental menopause-FI model. Materials and methods: The animal experiments were performed between September and November 2020 at Experimental Animal Application and Research Center, Afyon Kocatepe University, Afyonkarahisar, Turkey. Thirty-two female rats were divided into four groups: sham, saline, 10 mg/kg testosterone …
Comparison Of Primary Care Prescriptions For Old And Very Old Hypertensive Patients, Selcan Tülü Çolak, Caner Vizdiklar, Mert Kaşkal, Volkan Aydin, Ömer Ataç, Ahmet Akici
Comparison Of Primary Care Prescriptions For Old And Very Old Hypertensive Patients, Selcan Tülü Çolak, Caner Vizdiklar, Mert Kaşkal, Volkan Aydin, Ömer Ataç, Ahmet Akici
Turkish Journal of Medical Sciences
Background/aim: Elderly and very elderly individuals might be subject to different approaches for the treatment of hypertension. We aimed to compare drug utilization in hypertensive old patients and very old patients in primary care, along with the evaluation of potentially inappropriate drug prescribing. Materials and methods: In this cross-sectional study, we compared prescriptions of 65-79-year-old (old patient prescriptions [OPP], n = 433,988) vs. ≥80-year-old (very old patient prescriptions [VOPP], n = 134,079) with "essential hypertension" diagnosis, issued by 3:1 systematically-sampled primary care physicians (n = 1431) in İstanbul throughout 2016. Drug utilization patterns and distribution of antihypertensives based on drug …
Validity And Reliability Of The Turkish Version Of The Parent Perceptions Of Physical Activity Scale, Kami̇le Uzun Akkaya, Müjde Çalikuşu İncekar, Bülent Elbasan
Validity And Reliability Of The Turkish Version Of The Parent Perceptions Of Physical Activity Scale, Kami̇le Uzun Akkaya, Müjde Çalikuşu İncekar, Bülent Elbasan
Turkish Journal of Medical Sciences
Background/aim: The Parent Perceptions of Physical Activity Scale (PPPAS) is a scale developed to measure the physical activity perceptions of parents of children with neurodevelopmental disorders about their children. Turkish version of the PPPAS has yet to be established. The purpose of the present study is to examine the validity and reliability of the Turkish version of the PPPAS. Material and methods: The study included 130 parents with neurodevelopmental children. In the validity analyses of PPPAS, language validity, content validity analysis, and confirmatory and explanatory factor analysis were performed for construct validity. In the reliability analyses, Cronbach alpha analysis was …
Drug Interaction Potential Of Ankaferd Blood Stopper® In Human Hepatocarcinoma Cells, Asli Semi̇z
Drug Interaction Potential Of Ankaferd Blood Stopper® In Human Hepatocarcinoma Cells, Asli Semi̇z
Turkish Journal of Medical Sciences
Background/aim: Ankaferd blood stopper® (ABS) is an herbal extract consisting of mixtures of Alpinia officinarum, Gycyrrhiza glabra, Vitis vinifera, Thymus vulgaris, and Urtica dioica plants and has been used in recent years in Turkish medicine as a hemostatic agent. Despite its extensive usage, there is no information available about the drug interaction in HepG2 cells. The current work evaluated the effect of ABS on the expression of CYP1A1-1A2, CYP2E1, and CYP3A4 isozymes that are primarily involved in drug and carcinogen metabolism. Materials and methods: We selected HepG2 cells as in vitro cellular models of the human liver. The cells were …
The Diagnostic Value Of N-Terminal Probrain Natriuretic Peptides To Differentiate Neonatal Pneumoniae And Transient Tachypnea Of The Newborn, Zeynep Arslan, Serdar Alan, Di̇dem Ali̇efendi̇oğlu
The Diagnostic Value Of N-Terminal Probrain Natriuretic Peptides To Differentiate Neonatal Pneumoniae And Transient Tachypnea Of The Newborn, Zeynep Arslan, Serdar Alan, Di̇dem Ali̇efendi̇oğlu
Turkish Journal of Medical Sciences
Background/aim: The primary objective of the study was to determine the diagnostic value of serum N-terminal probrain natriuretic peptide (NT-proBNP) levels to differentiate neonatal pneumonia (NP) and transient tachypnea of the newborn (TTN). The secondary objective was to investigate the prognostic role of NT-proBNP levels in neonates with severe respiratory distress (RD). Materials and methods: A prospective, observational, single-blinded study involving 58 late preterm and term newborns who were diagnosed with TTN or NP was conducted between June 2020 and June 2021 at a level-3 neonatal intensive care unit in Kırıkkale University Faculty of Medicine. TTN and NP groups were …
A Prospective Study For An Alternative Probe Site For Pulse Oximetry Measurement In Male Patients With Severe Burn Trauma: Penile Shaft, Yeşi̇m Andiran Şenayli, Gülsen Keski̇n, Mi̇ne Akin, Ati̇lla Şenayli, Rabi̇a Ata, Gökhan Demi̇rtaş, Emrah Şenel
A Prospective Study For An Alternative Probe Site For Pulse Oximetry Measurement In Male Patients With Severe Burn Trauma: Penile Shaft, Yeşi̇m Andiran Şenayli, Gülsen Keski̇n, Mi̇ne Akin, Ati̇lla Şenayli, Rabi̇a Ata, Gökhan Demi̇rtaş, Emrah Şenel
Turkish Journal of Medical Sciences
Background/aim: Authors widely use pulse oximetry in clinical monitoring of heart rate (HR) and peripheral oxygen saturation (SpO2) by attachment to the fingers; however, there can be a need for an alternative attachment site, especially for burned patients. We investigate the availability of a pulse oximeter probe attached to the penile shaft as an alternative site in pediatric male patients if all extremities became unavailable for pulse oximetry measurement due to severe burn and/or trauma. Materials and methods: We designed a prospective comparative study in a training and research hospital. After local ethical committee approval, pediatric male cases eligible for …
The Predictive Significance Of Umbilical Cord Bilirubin And Bilirubin/Albumin Ratio For Neonatal Jaundice In Healthy Term Newborns, Handan Şahan, Selvi̇ Gülaşi, Mustafa Kurthan Mert, Eren Kale Çeki̇nmez
The Predictive Significance Of Umbilical Cord Bilirubin And Bilirubin/Albumin Ratio For Neonatal Jaundice In Healthy Term Newborns, Handan Şahan, Selvi̇ Gülaşi, Mustafa Kurthan Mert, Eren Kale Çeki̇nmez
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to determine the value of the questions asked in routine follow-up, the cord blood bilirubin (CBB) and bilirubin/albumin (B/A) ratio in estimating the risk of developing hyperbilirubinemia. Materials and methods: Term and healthy 217 newborns whose CBB and albumin could be obtained and whose needed to be measured bilirubin level at the 24th and 72nd hours of life were included. Nutrition, sex and nationality, consanguinity between parents, jaundice in the sibling (s), mother's medications were questioned. CBB and albumin, serum total bilirubin (STB), serum albumin and transcutaneous bilirubin (TcB) at the 24th and …
Body Proportions In Patients With Turner Syndrome On Growth Hormone Treatment, Asli Derya Kardelen Al, Nur Mi̇ne Şükür, Esi̇n Karakiliç Özturan, Ayşe Pinar Öztürk, Şükran Poyrazoğlu, Fi̇rdevs Baş, Fatma Feyza Darendeli̇ler
Body Proportions In Patients With Turner Syndrome On Growth Hormone Treatment, Asli Derya Kardelen Al, Nur Mi̇ne Şükür, Esi̇n Karakiliç Özturan, Ayşe Pinar Öztürk, Şükran Poyrazoğlu, Fi̇rdevs Baş, Fatma Feyza Darendeli̇ler
Turkish Journal of Medical Sciences
Background: In this cross-sectional study, we aimed to evaluate auxological measurements and detailed body proportions of recombinant human growth hormone (GH)-treated patients with Turner syndrome (TS) and compare them with a group of healthy females. Materials and methods: We evaluated 42 patients with TS who received GH treatment and 20 healthy controls. Anthropometric measurements were taken and target height, body mass index (BMI), arm span-height difference, extremity-to-trunk ratio, and Manouvrier's skelic index were calculated. Results: The median (min-max) age of the patients at the time of evaluation was 13.6 (4.3-20.7) years, and the control group was 12.9 (3.8-23.7) years. Height, …
Outcomes Of Kidney Transplantation In Patients With Congenital Anomalies Of The Kidney And Urinary Tract: A Propensity-Score-Matched Analysis With Case-Control Design, Özgür Akin Oto, Şafak Mi̇ri̇oğlu, Hali̇l Yazici, Ahmet Burak Di̇ri̇m, Nurane Güller, Seda Şafak, Erol Demi̇r, Ayşe Serra Artan, Mesude Yasemi̇n Özlük, Aydin Türkmen, Yaşar Kerem Çalişkan, Krista L. Lentine
Outcomes Of Kidney Transplantation In Patients With Congenital Anomalies Of The Kidney And Urinary Tract: A Propensity-Score-Matched Analysis With Case-Control Design, Özgür Akin Oto, Şafak Mi̇ri̇oğlu, Hali̇l Yazici, Ahmet Burak Di̇ri̇m, Nurane Güller, Seda Şafak, Erol Demi̇r, Ayşe Serra Artan, Mesude Yasemi̇n Özlük, Aydin Türkmen, Yaşar Kerem Çalişkan, Krista L. Lentine
Turkish Journal of Medical Sciences
Background/aim: We compared long-term outcomes after kidney transplantation (KTx) in patients with and without congenital anomalies of the kidney and urinary tract (CAKUT). Materials and methods: KTx recipients (KTRs) with CAKUT in 1980-2016 were identified; their hard copy and electronic medical records were reviewed and compared to a propensity-score-matched control group (non-CAKUT) from the same period. The primary outcomes were graft loss or death with a functioning graft; secondary outcomes included posttransplant urinary tract infections (UTIs) and biopsy-proven rejection (BPR). Results: We identified 169 KTRs with CAKUT and 169 matched controls. Median follow-up was 132 (IQR: 75.0-170.0) months. UTIs were …
Screening Of Antigliadin And Antitissue Transglutaminase Antibodies In Patients With Chronic Plaque Psoriasis: A Case-Control Study, Burhan Engi̇n, Chinara Huseynova, Tümay Ak, Ali̇ Yağiz Ayla, Günay Can, Serdal Uğurlu
Screening Of Antigliadin And Antitissue Transglutaminase Antibodies In Patients With Chronic Plaque Psoriasis: A Case-Control Study, Burhan Engi̇n, Chinara Huseynova, Tümay Ak, Ali̇ Yağiz Ayla, Günay Can, Serdal Uğurlu
Turkish Journal of Medical Sciences
Background/aim: In this study, we aimed to investigate different types of celiac antibodies in psoriasis patients and to see if the presence of the antibodies was associated with other variables. Materials and methods: We included patients with plaque psoriasis who were followed up in our dermatology clinic between February 2019 and February 2021 and added a healthy control group for comparison. The antibodies studied were serum antitissue transglutaminase (tTG)-IgA, tTG-IgG, antigliadin antibody (AGA)-IgA, and AGA-IgG. The patients' records were used to note age, sex, the pattern of psoriasis involvement, psoriasis area and severity index (PASI), presence of hypertension, presence of …