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Articles 4531 - 4560 of 4871
Full-Text Articles in Medicine and Health Sciences
Effects Of Angiotensin Converting Enzyme Inhibitors In Healthy Rats And In Rats With Carbon Tetrachloride-Induced Toxic Hepatitis, Ercüment Ovali, Mustafa Çeti̇ner, Si̇ret Rati̇p, Fazil Aydin, Yavuz Tekeli̇oğlu, Sami̇ Karti, Asim Örem, Gökhan Harova, Levent Albayrak, Nazim Ağaoğlu
Effects Of Angiotensin Converting Enzyme Inhibitors In Healthy Rats And In Rats With Carbon Tetrachloride-Induced Toxic Hepatitis, Ercüment Ovali, Mustafa Çeti̇ner, Si̇ret Rati̇p, Fazil Aydin, Yavuz Tekeli̇oğlu, Sami̇ Karti, Asim Örem, Gökhan Harova, Levent Albayrak, Nazim Ağaoğlu
Turkish Journal of Medical Sciences
Sulphydryl-containing captopril (CPR) appears to act as a scavanger of oxygen derived free radicals. This is not present in other angiotensin-converting enzymes such as enalapril (EPR). The hepatotoxic effect of carbon tetrachloride (CCl4) may result from induction of reactive oxygen free radicals. The aim of this study was to analyse the effects of CPR and non- sulphydryl-containing enalapril (EPR) in healthy rats and in rats with CCL4-induced toxic hepatitis. The rats were divided into two major groups. The first group consisted of healthy rats, and the second group consisted of rats with CCl4- induced toxic hepatitis. Each major group was …
Evaluation Of Chitosan As A Potential Medical Iron (Iii) Ion Adsorbent, Ayer Burke, Elvan Yilmaz, Nesri̇n Hasirci
Evaluation Of Chitosan As A Potential Medical Iron (Iii) Ion Adsorbent, Ayer Burke, Elvan Yilmaz, Nesri̇n Hasirci
Turkish Journal of Medical Sciences
Chitosan, a derivative of the natural polysaccharide chitin, is known for its biocompatibility and metal-binding capacity. The aim of this study was to combine these two properties of chitosan and investigate its potential as a new iron (III) ion (ferric ion) adsorbing agent. The development of a safe and orally active iron chelating agent is especially important for the treatment of thalassemics. In this study, the physicochemical parameters affecting the ability of chitosan flakes to adsorb iron (III) ions were studied by complexometric titration. The results showed that the iron (III) adsorption capacity of chitosan increases with the amount of …
Infective Panniculitis In A Child With Juvenile Rheumatoid Arthritis And Iga Deficiency, Ayça Törel Ergür, Meli̇h Akyol, Esi̇n Yildiz
Infective Panniculitis In A Child With Juvenile Rheumatoid Arthritis And Iga Deficiency, Ayça Törel Ergür, Meli̇h Akyol, Esi̇n Yildiz
Turkish Journal of Medical Sciences
No abstract provided.
Biosynthesis Of Polyhydroxybutyrate And Its Copolymers And Their Use In Controlled Drug Release, Füsun Türesi̇n, Zeynep Gümüşyazici, Fatma N. Kök, İhsan Gürsel, N. Gürdal Alaeddi̇noğlu, Vasif Hasirci
Biosynthesis Of Polyhydroxybutyrate And Its Copolymers And Their Use In Controlled Drug Release, Füsun Türesi̇n, Zeynep Gümüşyazici, Fatma N. Kök, İhsan Gürsel, N. Gürdal Alaeddi̇noğlu, Vasif Hasirci
Turkish Journal of Medical Sciences
Our aim was to prepare antibiotic loaded rods with biotechnologically produced biodegradable polymers and use them in the treatment of osteomyelitis by providing a high local dose of antibiotic at the infected site. For that purpose, first the production of PHB and its copolymers (P(3HB- co-3HV) and P(3HB- co-4HB)) by Alcaligenes latus and Alcaligenes eutrophusin the shake-flask cultures and in a fed-batch fermenter and their purification and characterization were performed. The polymers were then used in the preparation of the sulbactam-cefoperazone loaded rods. To predict the in vivo behavior of the controlled release system, the in vitro release kinetics of …
Elevated Serum \Beta-Hcg Levels In Severepreeclampsia, Remzi̇ Gökdeni̇z, Erdal Arigüloğlu, Nursel Bazoğlu, Özcan Balat
Elevated Serum \Beta-Hcg Levels In Severepreeclampsia, Remzi̇ Gökdeni̇z, Erdal Arigüloğlu, Nursel Bazoğlu, Özcan Balat
Turkish Journal of Medical Sciences
Most current hypotheses regarding the pathophysiologic mechanisms of pregnancy-induced hypertention point to early placental abnormalities. Therefore, we attempted to determine whether serum human chorionic gonadotropin (hCG) levels reflect a different trophoblastic secretory response of preeclampsia. Thirteen pregnant women with severe preeclampsia were matched with twenty-one normotensive pregnant women with singleton pregnancies in the third trimester. Serum b-hCG levels were found to be significantly higher in severe preeclampsia, compared with controls (p
Mri In Joubert Syndrome, Nai̇l Bulakbaşi, Taner Üçöz, Cem Tayfun, Yüksel Pabuşçu, Alper Alemdaroğlu
Mri In Joubert Syndrome, Nai̇l Bulakbaşi, Taner Üçöz, Cem Tayfun, Yüksel Pabuşçu, Alper Alemdaroğlu
Turkish Journal of Medical Sciences
No abstract provided.
The Effect Of Halothane On The Enzymatic Activity Of Mouse Liver And Erythrocyte Glucose-6- Phosphate Dehydrogenase, Ergül Belge Kurutaş, Güneş T. Yüregi̇r, İlhan Tuncer
The Effect Of Halothane On The Enzymatic Activity Of Mouse Liver And Erythrocyte Glucose-6- Phosphate Dehydrogenase, Ergül Belge Kurutaş, Güneş T. Yüregi̇r, İlhan Tuncer
Turkish Journal of Medical Sciences
The effects of repeated halothane anaesthesia on 6-10 week old male, Mus musculus albino mice weighing 29-32 g were studied. Halothane, a widely used anaesthetic, is known to be metabolised in the liver to toxic intermediates through cytochrome P4502E1 (CYP2E1). During the first week of repeated dosage, glucose-6- phosphate dehydrogenase (G6PDH) activity decreased in both erythrocytes and liver cells, and during this time, livers increased significantly in weight and suffered histopathological damage, the damage increasing with the dosage of halothane, in the range 0.25-1.0 ml twice daily. When repeated anaesthesia was continued for a second week, G6PDH activity increased significantly …
Assessment Of Proliferative Activity In Soft Tissue Sarcomas Showing Pcna And Ki-67 Reactivity Immunohistochemically, Özlem Aydin, Canan Ersöz, Serdar Özbarlas, Gülşah Şeydaoğlu
Assessment Of Proliferative Activity In Soft Tissue Sarcomas Showing Pcna And Ki-67 Reactivity Immunohistochemically, Özlem Aydin, Canan Ersöz, Serdar Özbarlas, Gülşah Şeydaoğlu
Turkish Journal of Medical Sciences
The aim of this study was to determine PCNA (Proliferating Cell Nuclear Antigen) and Ki-67 expression of various soft tissue sarcomas (STS) immunohisto-chemically and to correlate with the histologic grade of these tumors. Retrospectively 185 cases of STS were re-examined. Of the 185 cases, 35 primary STS cases which were localized in the extremities and trunk wall were included in this study. Anti-PCNA and Anti-Ki-67 monoclonal antibodies were applied to the paraffin sections of tumor tissues immunohistochemically. A semiquantitative score was employed to assess the percentage of cells that were positively stained. The comparison of the positively stained tumor cell …
Congenital Chylothorax, Ni̇lgün Köksal, Sultan Demi̇r, Mehmet Okan, Cengi̇z Gebi̇teki̇n, Işik Şenkaya
Congenital Chylothorax, Ni̇lgün Köksal, Sultan Demi̇r, Mehmet Okan, Cengi̇z Gebi̇teki̇n, Işik Şenkaya
Turkish Journal of Medical Sciences
No abstract provided.
Klippel-Trenaunay Syndrome, Pinar Polat, Beşi̇r Erdoğmuş, Suat Eren, Selami̇ Suma, Abdul Meci̇t Kantarci
Klippel-Trenaunay Syndrome, Pinar Polat, Beşi̇r Erdoğmuş, Suat Eren, Selami̇ Suma, Abdul Meci̇t Kantarci
Turkish Journal of Medical Sciences
No abstract provided.
Biodegradable Implants In Orthopaedics And Traumatology, Haluk Yetki̇n, Alpaslan Şenköylü, Erdal Ci̇la, Aki̇f Muhtar Öztürk, Sezai̇ Aykin Şi̇mşek
Biodegradable Implants In Orthopaedics And Traumatology, Haluk Yetki̇n, Alpaslan Şenköylü, Erdal Ci̇la, Aki̇f Muhtar Öztürk, Sezai̇ Aykin Şi̇mşek
Turkish Journal of Medical Sciences
Biodegradable implants are an alternative to metallic implants and have the advantage of not being necessary to remove once the fracture has healed. Twenty-two patients with fractures were treated with biodegradable implants. There were osteolysis in eleven patients; however, no serious complication was encountered. Although biodegradable implants are expensive, a second surgical procedure to remove the implants is not necessary, relieving the patient of the related costs and risks.
Effect Of Low-Intensity Microwave Radiation On Rat Kidney: An Ultrastructural Study, Yusuf Nergi̇z, M. Aydin Ketani̇, Zülküf Akdağ, Ahmet Reşi̇t Ersay, M. Sali̇h Çeli̇k
Effect Of Low-Intensity Microwave Radiation On Rat Kidney: An Ultrastructural Study, Yusuf Nergi̇z, M. Aydin Ketani̇, Zülküf Akdağ, Ahmet Reşi̇t Ersay, M. Sali̇h Çeli̇k
Turkish Journal of Medical Sciences
Exposure to low-intensity microwave radiation for prolonged periods is known to be a potential factor inducing visceral damage. There are several studies in the literature demonstrating the harmful effects of such radiation on the kidney of laboratory animals. Our aim was to determine the effect of low intensity microwave radiation on rat kidney at the light and electron microscopic level. Animals (28 rats) in the experiment group were exposed to 2.65 mW/cm 2 radition (9450 MHz) for 1 h per day during 26 and 52 days respectively and tissue samples of these animals were examined and compared with those of …
Lymphocyte Subsets In Acute Post-Streptococcal Glomerulonephritis, Yavuz Tekeli̇oğlu, Hi̇lal Mocan, M. Zi̇ya Mocan, H. Önder Ersöz
Lymphocyte Subsets In Acute Post-Streptococcal Glomerulonephritis, Yavuz Tekeli̇oğlu, Hi̇lal Mocan, M. Zi̇ya Mocan, H. Önder Ersöz
Turkish Journal of Medical Sciences
This prospective study was designed to investigate lymphocyte subsets in acute post-streptococcal glomerulonephritis (APSGN). Peripheral blood lymphocytes were analyzed using fluorescein isothiocyanate (FITC) labeled CD3, CD4, CD8, CD14, CD19, CD45, CD56, CD45RA and CDW29 monoclonal antibodies by flow cytometry. Twenty patients aged 14-22 years who fulfilled the diagnostic criteria for APSGN were evaluated during the 1st and 12th weeks of the of disease. Twenty-four age-matched healthy subjects served as controls. At the onset of the disease, all patients had macroscopic haematuria with red blood cell casts in urine, proteinuria (1.06±0.21 g/d), low complement 3 (C3) levels (200 IU/ml), edema, oliguria …
Telomeric Repeats Of Immortal Hamster Cells, Nedi̇me Serakinci, Jorn Koch
Telomeric Repeats Of Immortal Hamster Cells, Nedi̇me Serakinci, Jorn Koch
Turkish Journal of Medical Sciences
We have analyzed telomeres in four hamster cell lines to investigate how telomeres look in cells grown past the Hayflick limit. In all four cell lines telomeric signals were seen after detection with two different sensitive in situ methods (FISH with PNA probes and PRINS). The telomeric signals were not very strong, suggesting that the repeats are very short, but were nevertheless clearly visible. With the PRINS technique, it was further possible to probe also for the presence of variant telomeric repeats at the chromosome ends. With some of the variant repeat probes, a difference was seen between probes for …
A Comparative Analysis Of Perinatal Development Of Barrel Cortex In Rat, Mouse And Guinea Pig Using Acetylcholinesterase Histochemistry, Erdoğan Şendemi̇r
A Comparative Analysis Of Perinatal Development Of Barrel Cortex In Rat, Mouse And Guinea Pig Using Acetylcholinesterase Histochemistry, Erdoğan Şendemi̇r
Turkish Journal of Medical Sciences
The role of acetylcholinesterase (AChE) in the developing neocortex was reexamined by comparing its expression in rats, mice and guinea pigs, following the protocol for acetylcholinesterase histochemistry (described in Sendemir et al., 1996) in order to determine the suitability of the breeding colony at UludaÛ University for use as an animal model. A total of 103 pups as well as two adult animals of each species were used. In the rat pups, acetylcholinesterase-rich patches were distributed in a vibrissa-related array in the somatosensory cortex soon after birth, whereas regions of the cortex lying between individual patches and between rows of …
Identification Of Different Candida Species Isolated In Various Hospitals In Ankara By Fungichrom Test Kit And Their Differentiation By Sds-Page, Özlem Osmanağaoğlu, Nurten Altinlar, Sefa Can Saçilik, Cumhur Çökmüş, Ahmet Akin
Identification Of Different Candida Species Isolated In Various Hospitals In Ankara By Fungichrom Test Kit And Their Differentiation By Sds-Page, Özlem Osmanağaoğlu, Nurten Altinlar, Sefa Can Saçilik, Cumhur Çökmüş, Ahmet Akin
Turkish Journal of Medical Sciences
Identification of 78 Candida isolates was carried out by a commercial Fungichrom test kit, the reliability of which was further confirmed by conventional biochemical tests and the API 20C kit. Differentiation between different Candida species was also observed when sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) of whole cell proteins was used. The most frequently isolated species of yeast from vaginal swabs obtained from patients was Candida albicans, which accounted for 39 of 78 (50.00%) of the isolates from women in Ankara. The next most frequent Candida species were Candida glabrata ( Torulopsis glabrata) and Candida krusei, which were isolated …
Alterations Of Muc2 Mucin In Colorectal Adenocarcinoma, Nurten Aksoy, Anthony P. Corfield, Christos Paraskeva, David J. Thornton, John K. Sheehan
Alterations Of Muc2 Mucin In Colorectal Adenocarcinoma, Nurten Aksoy, Anthony P. Corfield, Christos Paraskeva, David J. Thornton, John K. Sheehan
Turkish Journal of Medical Sciences
MUC2 is a well-identified intestinal mucin, present predominantly in the small intestine and colon. It is known that pathological alterations in the expression and composition of this mucin occur in several serious diseases related to epithelial surfaces, e.g., carcinoma and colitis ulcerosa. In this study, our aim was to find out whether there are any specific alterations in the expression and secretion of MUC2 in an adenoma- adenocarcinoma sequence that has been established as an in vitro model (1,2). The adenoma-carcinoma sequence represents the first example of the malignant progression of human colonic adenoma cells in vitro (2,3). Using a …
Analysis Of Methicillin Resistant Staphylococcus Aureus Isolates By Polyacrylamide Gel Electrophoresis In An Intensive Care Unit Of Übni-Sina Hospital, Sefa Can Saçilik, Özlem Osmanağaoğlu, İffet Palabiyikoğlu, J. Sedef Bengi̇sun, Cumhur Çökmüş
Analysis Of Methicillin Resistant Staphylococcus Aureus Isolates By Polyacrylamide Gel Electrophoresis In An Intensive Care Unit Of Übni-Sina Hospital, Sefa Can Saçilik, Özlem Osmanağaoğlu, İffet Palabiyikoğlu, J. Sedef Bengi̇sun, Cumhur Çökmüş
Turkish Journal of Medical Sciences
This study was designed in order to evaluate the relationship of MRSA isolates obtained from an intensive care unit (ICU) and other wards as well as the epidemiological features and typing methods. Two polyacrylamide gel electrophoretic methods of typing MRSA isolates-sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS- PAGE) and native-PAGE (N-PAGE) were evaluated and their antibiotic susceptibility patterns were determined. MRSA isolates were investigated according to the whole cell proteins (WCPs) and filtrate proteins (FPs). No report has been published yet explaining the characterization of staphylococci in SDS-PAGE by use of filtrate protein profiles. One clonal group was identified by …
A Case Of Partial Trisomy 13 Findings With 46,Xx,Der(7)T(7;13)(P22;Q31)Mat Karyotype, E. Ferda Perçi̇n, Y. Selma Sungu, Hati̇ce Ilgin Ruhi̇, Ayça Törel Ergur, Füsun Düzcan, İlhan Sezgi̇n
A Case Of Partial Trisomy 13 Findings With 46,Xx,Der(7)T(7;13)(P22;Q31)Mat Karyotype, E. Ferda Perçi̇n, Y. Selma Sungu, Hati̇ce Ilgin Ruhi̇, Ayça Törel Ergur, Füsun Düzcan, İlhan Sezgi̇n
Turkish Journal of Medical Sciences
No abstract provided.
Hvj-Liposome-Mediated Gene Transfer To Healing Rat Meniscal Tissue, İlhan Özkan, Norimasa Nakamura, Konsei Shino, Takashi Natsu-Ume, Tetsuya Tomita, Yasufumi Kaneda, Takahiro Ochi
Hvj-Liposome-Mediated Gene Transfer To Healing Rat Meniscal Tissue, İlhan Özkan, Norimasa Nakamura, Konsei Shino, Takashi Natsu-Ume, Tetsuya Tomita, Yasufumi Kaneda, Takahiro Ochi
Turkish Journal of Medical Sciences
The success rate of a repaired torn meniscus is not more than 70%. Gene transfer to healing soft tissues appears to be a feasible method for manipulating the healing process. In an attempt to evaluate the feasibility of gene transfer to meniscal tissue we tried to transfer a reporter gene ( Echerichia coli, b-galactosidase gene) by using HVJ-liposome mediated gene transfer. After performing complete radial tear on the medial meniscus of fifty 14-week-old male Wistar rats, HVJ-liposomes with DNA were injected into the femoral artery of 15 rats and into the knee joint of the other 15 rats. HVJ- liposomes …
Production And Characterization Of Monoclonal Anti-Ovalbumin Antibodies, Mehmet Zi̇ya Doymaz, Hakan Bulut, Aykut Özdarendeli̇, Yusuf Bolat
Production And Characterization Of Monoclonal Anti-Ovalbumin Antibodies, Mehmet Zi̇ya Doymaz, Hakan Bulut, Aykut Özdarendeli̇, Yusuf Bolat
Turkish Journal of Medical Sciences
In this study, the results of anti- ovalbumin (OVA) monoclonal antibody production and characterization are reported. Splenocytes from OVA-hyperimmune Balb/C mouse were fused with F0 myeloma cells and resulting hybridoma cells were selected in hypoxanthine-aminopterine-thymidine containing medium. A total of 37 HAT resistant hybridomas were obtained. Upon testing the hybridoma supernatants in OVA and mouse immunoglobulin G specific enzyme-linked immunosorbent assays, we observed that two of the hybridomas secreted OVA specific antibodies. The hybridomas produced IgG class antibodies. The hybridomas were grown and the supernatants from the cultures were also tested in a Western Blot assay. The results of ELISA …
The Radioprotective Effect Of Vitamins C, E And Vitamin E + Glutathione On The Small Intestine And The Thyroid Gland In Rats Irradiated With X- Rays, Cemi̇l Sert, M. Sali̇h Çeli̇k, Zülküf Akdağ, M. Aydin Ketani̇, Yusuf Nergi̇z
The Radioprotective Effect Of Vitamins C, E And Vitamin E + Glutathione On The Small Intestine And The Thyroid Gland In Rats Irradiated With X- Rays, Cemi̇l Sert, M. Sali̇h Çeli̇k, Zülküf Akdağ, M. Aydin Ketani̇, Yusuf Nergi̇z
Turkish Journal of Medical Sciences
This investigation was carried out in order to determine the protective effects of long term administration at supraphysiologi- cal doses of vitamin E, vitamin C and a compound of vitamin E + glutathione against damage induced by free radicals produced by ionizing radiation. Five groups of 8-10-week-old Wistar albino rats were used in the study. Group I was the sham group and Group II was the radiation group (i.e. radiation alone). The rats in Group III were given a daily dose of 400 mg/kg of vit. C for one month. The rats in Group IV were given a daily dose …
Antioxidant And Hepatoprotective Activity Of Vitamin E And Egb 761 In Experimental Endotoxemic Rats, Ömer Coşkun, Bi̇rkan Yakan, Emi̇n Öztaş, Şaban Sezen, Ali̇ A. Günaydin
Antioxidant And Hepatoprotective Activity Of Vitamin E And Egb 761 In Experimental Endotoxemic Rats, Ömer Coşkun, Bi̇rkan Yakan, Emi̇n Öztaş, Şaban Sezen, Ali̇ A. Günaydin
Turkish Journal of Medical Sciences
In this experimental study, we investigated whether vitamin E and EGb 761 have any influence on endotoxemic rats and liver histopathology. Forty rats were divided into four groups of 10 animals in each group. The control rats were untreated and comprised group 1. Two ml serum was applied to the rats intraperitoneally (i.p.) in group 2, and then 0.5 ml endotoxin solution ( E. Coli 0:157:H7, 10 9 bacteria/ml) was given to the same group two hours later. Not only endotoxin solution but also vitamin E (600 mg/kg) was given to the rats in group 3. Endotoxin solution and EGb …
Contralateral White Noise-Induced Enhancement In The Guinea Pigõs Mlr: A Possible Link To Direc- Tional Hearing, Cüneyt Göksoy, Rezzan Utkuçal
Contralateral White Noise-Induced Enhancement In The Guinea Pigõs Mlr: A Possible Link To Direc- Tional Hearing, Cüneyt Göksoy, Rezzan Utkuçal
Turkish Journal of Medical Sciences
The evoked potential components in a time window of 10-50 ms following an acoustic stimulus are called middle latency responses (MLRs). It is known that an amplitude enlargement occurs in guinea pig MLRs to monaural clicks when continuous white noise is applied to the other ear. This study was undertaken to see whether this enlargement is due simply to an overall, generalised effect of contralateral white noise (WN), or whether it may have some connection to directional hearing. Recordings were made from chronic guinea pig preparations with epidural electrodes in the temporal regions. Parallel to the results in the literature, …
Quinolone Arthropathy Induced By Ofloxacin In Juvenile Rats: A Light Microscopic Study, İlki̇n Çavuşoğlu, Zeynep Kahveci̇, Semi̇ha Noyan, Zehra Mi̇nbay
Quinolone Arthropathy Induced By Ofloxacin In Juvenile Rats: A Light Microscopic Study, İlki̇n Çavuşoğlu, Zeynep Kahveci̇, Semi̇ha Noyan, Zehra Mi̇nbay
Turkish Journal of Medical Sciences
This study was conducted to examine the development, progression and reversibility of cartilage lesions in juvenile rats that had been given ofloxacin, a fluoroquinolone. Four-week-old rats were treated with an oral dose of 900 mg/kg/day of ofloxacin for 7 days. The animals were sacrificed at different (1 st^day, 1 st^week, 2^nd week, 4 th^ week, 8 th^ week, 12 th^ week, 16 th^ week) after the completion of the administration and the knee joints were prepared for light microscopic analysis. The lesions were demonstrated in the articular cartilage of all the animals. Acellular, oedematous matrix areas, and cavity formations were …
The Effects Of Allopurinol On Stomach Mucosal Barrier Of Rats Subjected To Ischemia-Reperfusion, Abdurrahman Önen, Zeki̇ Kanay, Ci̇hat Güzel, Doğan Kurt, Kader Ceylan
The Effects Of Allopurinol On Stomach Mucosal Barrier Of Rats Subjected To Ischemia-Reperfusion, Abdurrahman Önen, Zeki̇ Kanay, Ci̇hat Güzel, Doğan Kurt, Kader Ceylan
Turkish Journal of Medical Sciences
The present experimental study was carried out on rats subjected to ischemia and reperfusion. The effects of allopurinol on mucus, an important component of the stomach mucosal barrier, were investigated. Twenty-one Swiss Albino rats, each weighing 200-250 g, were used. On the control group, no treatment was performed, while the sham operation group was subjected to 30 minutes of ischemia and 20 minutes of reperfusion. Then, stomachs were examined for ulcerative lesions, and ulcer scores were recorded. Mucus content was determined by the Corne method. In the sham group, the mucus decreased to a significant extent (p
Comparative Study Of Dopamine And Mannitol Effects On Renal Function During Cardiopulmonary Bypass By Using N-Acetyl-\Beta-D-Glucosaminidase Assay, Onur Dural, Asuman Özkara, Bi̇lge Çelebi̇oğlu, Meral Kanbak, Gönenç Ci̇li̇v, Ülkü Aypar
Comparative Study Of Dopamine And Mannitol Effects On Renal Function During Cardiopulmonary Bypass By Using N-Acetyl-\Beta-D-Glucosaminidase Assay, Onur Dural, Asuman Özkara, Bi̇lge Çelebi̇oğlu, Meral Kanbak, Gönenç Ci̇li̇v, Ülkü Aypar
Turkish Journal of Medical Sciences
The protective roles of low-dose dopamine and mannitol infusion in the renal function of patients undergoing cardiovascular surgery were compared in 36 patients by measuring urine N-acetyl-\beta-D- glucosaminidase activity, serum and urinary creatinine, blood urea nitrogen (BUN) levels and urine output. The patients were randomly selected and received a continuous infusion of dopamine, 3 µg/kg/min (Group I), mannitol, 1 mg/kg/h (Group II), no medication (Group III) before the induction of anaesthesia. Urine N- acetyl-\beta-D-glucosaminidase activities, serum and urinary creatinine and BUN were determined preoperatively after aortic cross- clamping, and on the first and second postoperative days. Changes in urine N-acetyl- …
Investigation Of Various Terminal Carbohydrate Structures In Apolipoproteins Of Human Serum Chylomicrons And Vldl, Tayfun Güldür, Tülay İleri̇ Büyükoğlu, Ramazan Yilmaz
Investigation Of Various Terminal Carbohydrate Structures In Apolipoproteins Of Human Serum Chylomicrons And Vldl, Tayfun Güldür, Tülay İleri̇ Büyükoğlu, Ramazan Yilmaz
Turkish Journal of Medical Sciences
The roles of terminal carbohydrate moieties of serum glycoproteins in their recognition and uptake by receptors and in their rapid removal from the circulation are well established. However, little is known about the detailed structure of the terminal glycan chains in apolipoproteins and their compatibility with the known ligand specificity of carbohydrate recognition systems. The carbohydrate moieties of apolipoproteins in human serum chylomicrons and VLDL were examined. Chylomicrons and VLDL were isolated from the serum by ultracentrifugation for 1.6x10 ^6 g.min and 5.5x10 ^7 g.min respectively. The top 1.5cm fraction containing chylomicrons or VLDL was recovered. Following delipidization, apolipoproteins were …
Determination Of Free Fatty Acid Composition In Plasma Membranes Of Neutrophils In Diabetics, Mevlüt Sai̇t Keleş, Yaşar Demi̇r, İrfan Altuntaş, Zuhal Umudum, Ebubeki̇r Bakan
Determination Of Free Fatty Acid Composition In Plasma Membranes Of Neutrophils In Diabetics, Mevlüt Sai̇t Keleş, Yaşar Demi̇r, İrfan Altuntaş, Zuhal Umudum, Ebubeki̇r Bakan
Turkish Journal of Medical Sciences
Since frequent and serious infections occur in diabetic patients, the investigation of the function of neutrophils is of importance. Any change in the lipid composition of the plasma membrane could be one of the causes of these infections. In order to investigate this possibility and to determine any abnormalities, neutrophils and monocytes were separated by the Histopaque- 1119 method from the blood samples (20 ml) of 10 diabetic and 10 healthy persons. After disruption of the cells, membrane lipids and proteins were isolated. Free fatty acids of phospholipids in membrane lipids were isolated by hydrolysing with phospholipase B under an …
Effects Of Four Different Hormone Replacement Therapy Regimens On Certain Cardiovascular Risk Factors, Erdal Malatyalioğlu, Ari̇f Kökçü, Fi̇li̇z F. Yanik, Tayfun Alper
Effects Of Four Different Hormone Replacement Therapy Regimens On Certain Cardiovascular Risk Factors, Erdal Malatyalioğlu, Ari̇f Kökçü, Fi̇li̇z F. Yanik, Tayfun Alper
Turkish Journal of Medical Sciences
This study was performed to compare the effects of 4 different hormone replacement therapy (HRT) protocols on certain cardiovascular risk factors. Eighty- nine postmenopausal women were treated with oral conjugated estrogens, transdermal 17 beta-E2, cyclic oral E2-17- valerate+cyproterone acetate (E2-17-V+CA) or tibolone. Blood pressure (BP) measurements, fasting blood glucose (FBG), serum total cholesterol, low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL) and triglyceride levels at the 12th month were compared with the pretreatment values in each treatment group. There were no significant changes in the systolic BP, FBG, serum total and LDL-cholesterol levels in any group. Diastolic BP …