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Full-Text Articles in Medicine and Health Sciences
Factors Affecting Relapse In Patients With Granulomatosis Polyangiitis: A Single-Centerretrospective Cohort Study, Müge Aydin Tufan, Ni̇han Tekkarişmaz, Ahmet Eftal Yücel
Factors Affecting Relapse In Patients With Granulomatosis Polyangiitis: A Single-Centerretrospective Cohort Study, Müge Aydin Tufan, Ni̇han Tekkarişmaz, Ahmet Eftal Yücel
Turkish Journal of Medical Sciences
Background and aim: This study aimed to determine the frequency of relapse, the risk factors for relapse, and the correlation of relapse with immunosuppressive regimens in patients with granulomatosis polyangiitis (GPA). Materials and methods: The demographic characteristics, the clinical, laboratory, and radiological findings, the immunosuppressive treatment regimens, and the remission and relapse rates of 50 patients with GPA were obtained retrospectively from medical records. Results: The mean relapse-free survival rates at years 1, 3, and 5 were 82%, 60%, and 50%, respectively. Increased relapse rates were observed in patients who had cavitary lung lesions (52.2% vs. 22.2%, p = 0.04) …
Pediatric Extracorporeal Cardiopulmonary Resuscitation: Single-Center Study, Tanil Kendi̇rli̇, Serhan Özcan, Merve Havan, Çağdaş Baran, Mehmet Çakici, Burcu Arici, Özlem Selvi̇ Can, Zeynep Eyi̇leten, Tayfun Uçar, Hasan Ercan Tutar, Ahmet Rüçhan Akar
Pediatric Extracorporeal Cardiopulmonary Resuscitation: Single-Center Study, Tanil Kendi̇rli̇, Serhan Özcan, Merve Havan, Çağdaş Baran, Mehmet Çakici, Burcu Arici, Özlem Selvi̇ Can, Zeynep Eyi̇leten, Tayfun Uçar, Hasan Ercan Tutar, Ahmet Rüçhan Akar
Turkish Journal of Medical Sciences
Background/aim: Extracorporeal cardiopulmonary resuscitation (ECPR) is defined as the venoarterial extracorporeal membrane oxygenation (VA-ECMO) support in a patient who experienced a sudden pulseless condition attributable to cessation of cardiac mechanical activity and circulation. We aimed to evaluate the clinical outcomes of our ECPR experience in a pediatric patient population. Materials and methods: Between September 2014 and November 2017, 15 children were supported with ECPR following in-hospital cardiac arrest (IHCA) in our hospitals. VA-ECMO setting was established for all patients. Pediatric cerebral performance category (PCPC) scales and long-term neurological prognosis of the survivors were assessed. Results: The median age of the …
The Relationship Of Carotid Intima-Media Thickness With Anthropometric And Metabolicparameters In Patients With Classic Congenital Adrenal Hyperplasia, Hale Ünver Tuhan, Tülay Öztürk Atasoy, Gönül Çatli, Sezer Acar, Ayhan Abaci, Tuğba Üçüncü Egeli̇, Korcan Demi̇r, Penbe Şule Can, Handan Güleryüz, Bumi̇n Nuri̇ Dündar, Ece Böber
The Relationship Of Carotid Intima-Media Thickness With Anthropometric And Metabolicparameters In Patients With Classic Congenital Adrenal Hyperplasia, Hale Ünver Tuhan, Tülay Öztürk Atasoy, Gönül Çatli, Sezer Acar, Ayhan Abaci, Tuğba Üçüncü Egeli̇, Korcan Demi̇r, Penbe Şule Can, Handan Güleryüz, Bumi̇n Nuri̇ Dündar, Ece Böber
Turkish Journal of Medical Sciences
Background/aim: We aimed to determine the presence of subclinical atherosclerosis using carotid intima-media thickness (CIMT) and biochemical parameters in children and adolescents with congenital adrenal hyperplasia (CAH). Materials and methods: Thirty-four patients with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency on regular glucocorticoid treatment for ≥3 years and 31 healthy subjects were included in the study. The patients were divided into two groups according to the degree of control of the clinic, laboratory, and radiological parameters as a) "uncontrolled" [n= 22; with increased height velocity (HV) standard deviation score (SDS) (≥2 SDS), advanced bone age, serum 17-OH progesterone 0.05]. …
Attention-Deficit Hyperactivity Disorder Symptoms And Quality Of Life In Female Patientswith Fibromyalgia, Gözde Türkoğlu, Yavuz Selvi̇
Attention-Deficit Hyperactivity Disorder Symptoms And Quality Of Life In Female Patientswith Fibromyalgia, Gözde Türkoğlu, Yavuz Selvi̇
Turkish Journal of Medical Sciences
Background/aim: The present study aimed to determine the association between attention-deficit hyperactivity disorder (ADHD) symptoms severity, fibromyalgia (FM) severity, and QoL. Materials and methods: While the FM group consisted of 113 (74%) patients, the control group consisted of 40 (26%) individuals. FM symptom severity, ADHD symptom severity, and QoL were evaluated using the fibromyalgia impact questionnaire (FIQ), adult ADHD self-report scale (ASRS), and World Health Organization quality of life scale-brief version (WHOQOL-BREF), respectively. Results: It was found that the FM group had significantly higher scores on the ASRS than the control group (p < 0.05). There was a significant difference in FIQ scores and three WHOQOL-BREF domain scores between the FM alone and comorbid FM/high probability of ADHD groups (p < 0.05). We found a negative correlation between ASRS total scores and all other scale scores (except for the social relationships domain score of the WHOQOL-BREF) and a positive correlation between ASRS total scores and FIQ scores in FM patients. ADHD scores would mediate the relationship between depression severity and QoL. Conclusions: Our findings indicated that the presence of ADHD symptoms was related to greater FM symptom severity and poorer QoL. Also, ADHD scores would mediate the relationship between depression severity and QoL.
The Use Of High-Flow Nasal Oxygen Vs. Standard Oxygen Therapy In Hematologicalmalignancy Patients With Acute Respiratory Failure In Hematology Wards, Ni̇lgün Özlem Alpteki̇noğlu Mendi̇l, Şahi̇n Temel, Recep Ci̇van Yüksel, Kürşat Gündoğan, Bülent Eser, Leylagül Kaynar, Murat Sungur
The Use Of High-Flow Nasal Oxygen Vs. Standard Oxygen Therapy In Hematologicalmalignancy Patients With Acute Respiratory Failure In Hematology Wards, Ni̇lgün Özlem Alpteki̇noğlu Mendi̇l, Şahi̇n Temel, Recep Ci̇van Yüksel, Kürşat Gündoğan, Bülent Eser, Leylagül Kaynar, Murat Sungur
Turkish Journal of Medical Sciences
Background/aim: High flow nasal cannula (HFNC) was mostly used in intensive care units (ICUs) with few studies in other departments. We hypothesized that HFNC applied at wards is beneficial for acute respiratory failure in hematological malignancy patients. Materials and methods: The study is a single center, randomized controlled study. Inclusion criteria were hypoxemic respiratory failure and hematological malignancy. Patients were randomized to either venturi mask/nasal cannula oxygen treatment or HFNC. Results: One hundred patients were included in the study. Median age was 58.5 (18-86) years and APACHE II score was 17 (5-29). HFNC group was 51 patients and the oxygen …
Investigating Differential Mirna Expression Profiling Using Serum And Urine Specimensfor Detecting Potential Biomarkers For Early Prostate Cancer Diagnosis, Sevde Hasanoğlu, Beyza Servet Göncü, Emrah Yücesan, Sezen Atasoy, Yunus Kayali, Nur Özten Kandaş
Investigating Differential Mirna Expression Profiling Using Serum And Urine Specimensfor Detecting Potential Biomarkers For Early Prostate Cancer Diagnosis, Sevde Hasanoğlu, Beyza Servet Göncü, Emrah Yücesan, Sezen Atasoy, Yunus Kayali, Nur Özten Kandaş
Turkish Journal of Medical Sciences
Background/aim: MicroRNAs (miRNAs) are known up-to-date candidate biomarkers for several diseases. In addition, obtaining miRNA from different body fluids such as serum, plasma, saliva, and urine is relatively easy to handle. Herein we aimed to detect miRNAs as biomarkers for early stage prostate cancer (PC). For this purpose, we used urine and serum samples to detect any significant differences in miRNA profiles between patients and healthy controls. Materials and methods: Total ribonucleic acid (RNA) in urine and serum samples were isolated from eight untreated PC patients, thirty healthy individuals were screened for miRNA profile, and candidate miRNAs were validated. Whole …
20-Year Experience On Prenatal Diagnosis In A Reference University Medical Geneticscenter In Turkey, Mehmet Burak Durmaz, Hi̇lmi̇ Bolat, Zehra Cengi̇si̇z, Fuat Akercan, Tuba Sözen Türk, Erhan Pariltay, Asli Ece Solmaz, Mert Kazandi, Emi̇n Karaca, Asude Durmaz, Ayça Aykut, Sermet Sağol, Haluk Akin, Feri̇ştah Ferda Özkinay, Muhsi̇n Özgür Çoğulu
20-Year Experience On Prenatal Diagnosis In A Reference University Medical Geneticscenter In Turkey, Mehmet Burak Durmaz, Hi̇lmi̇ Bolat, Zehra Cengi̇si̇z, Fuat Akercan, Tuba Sözen Türk, Erhan Pariltay, Asli Ece Solmaz, Mert Kazandi, Emi̇n Karaca, Asude Durmaz, Ayça Aykut, Sermet Sağol, Haluk Akin, Feri̇ştah Ferda Özkinay, Muhsi̇n Özgür Çoğulu
Turkish Journal of Medical Sciences
Background/aim: Although cutting edge procedures such as cell-free fetal DNA isolation from maternal blood are now available, invasive prenatal tests are still being used extensively for prenatal diagnosis. The study aims to evaluate the demographic data, indications, and cytogenetic results of 9297 results of patients who underwent prenatal invasive testing for genetic analysis that were referred for the last 20 years in a University Medical Genetics Center. Materials and methods: The records of 8363 amniocenteses, 626 chorionic villus, and 308 cordocenteses samples were retrospectively evaluated and analyzed regarding referral reasons, indications and their cytogenetic results. The total numbers and the …
Rituximab Treatment For Difficult-To-Treat Nephrotic Syndrome In Children:A Multicenter, Retrospective Study, Mehmet Taşdemi̇r, Nur Canpolat, Nurdan Yildiz, Gül Özçeli̇k, Meryem Benzer, Seha Kami̇l Saygili, Emi̇ne Neşe Özkayin, Özde Ni̇sa Türkkan, Ayşe Balat, Cengi̇z Candan, Mehtap Çelakil, Sevgi̇ Yavuz, Nurver Akinci, Ni̇lüfer Göknar, Ci̇hangi̇r Akgün
Rituximab Treatment For Difficult-To-Treat Nephrotic Syndrome In Children:A Multicenter, Retrospective Study, Mehmet Taşdemi̇r, Nur Canpolat, Nurdan Yildiz, Gül Özçeli̇k, Meryem Benzer, Seha Kami̇l Saygili, Emi̇ne Neşe Özkayin, Özde Ni̇sa Türkkan, Ayşe Balat, Cengi̇z Candan, Mehtap Çelakil, Sevgi̇ Yavuz, Nurver Akinci, Ni̇lüfer Göknar, Ci̇hangi̇r Akgün
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate the efficacy of rituximab in children with difficult-to-treat nephrotic syndrome, considering the type of disease (steroid-sensitive or -resistant) and the dosing regimen. Materials and methods: This multicenter retrospective study enrolled children with difficult-to-treat nephrotic syndrome on rituximab treatment from 13 centers. The patients were classified based on low (single dose of 375 mg/m2 ) or high (2-4 doses of 375 mg/m2 ) initial dose of rituximab and the steroid response. Clinical outcomes were compared. Results: Data from 42 children [20 steroid-sensitive (frequent relapsing / steroid-dependent) and 22 steroid-resistant nephrotic syndrome, aged 1.9-17.3 years] were …
Evaluation Of Seroprevalence And Clinical And Laboratory Findings Of Patients Admitted Tohealth Institutions In Gümüşhane With Suspicion Of Crimean-Congo Hemorrhagic Fever, Esra Gürbüz, Abdurrahman Eki̇ci̇, Ahmet Hakan Ünlü, Hasan Yilmaz
Evaluation Of Seroprevalence And Clinical And Laboratory Findings Of Patients Admitted Tohealth Institutions In Gümüşhane With Suspicion Of Crimean-Congo Hemorrhagic Fever, Esra Gürbüz, Abdurrahman Eki̇ci̇, Ahmet Hakan Ünlü, Hasan Yilmaz
Turkish Journal of Medical Sciences
Background/aim: To determine the seroprevalence and evaluate clinical findings and laboratory results of patients prediagnosed with Crimean-Congo hemorrhagic fever (CCHF) in Gümüşhane. Materials and methods: Included in the cross-sectional study were 362 patients (162 female, 200 male) between 0 and 94 years of age, who were followed up after receiving a preliminary diagnosis of CCHF between January 2011 and December 2019. Anamnesis, age, sex, clinical findings, laboratory results, epidemiological and clinical evaluations, severity criteria, risk factor reviews, and a comparison of the suspected negative cases with positive cases were analyzed retrospectively. Patients included in the study were evaluated as RNApositive …
Investigation Of The Relationship Between Immune Checkpoints And Mismatch Repairdeficiency In Recurrent And Nonrecurrent Glioblastoma, Emel Çakir, İsmai̇l Sayğin, Mustafa Emre Erci̇n
Investigation Of The Relationship Between Immune Checkpoints And Mismatch Repairdeficiency In Recurrent And Nonrecurrent Glioblastoma, Emel Çakir, İsmai̇l Sayğin, Mustafa Emre Erci̇n
Turkish Journal of Medical Sciences
Background/aim: Microsatellite instability tests and programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) in the immune checkpoint pathway are the tests that determine who will benefit from immune checkpoint inhibitor therapy. We aimed to show the expression of DNA mismatch repair proteins and PD-1/PD-L1 molecules that inhibit immune checkpoints, to explain the relationship between them, and to demonstrate their predictive role in recurrent and nonrecurrent glioblastoma. Materials and methods: We analyzed 27 recurrent and 47 nonrecurrent cases at our archive. We performed immunohistochemical analysis to determine expressions of PD-1, PD-L1, and mismatch repair proteins in glioblastoma. We evaluated the relationship …
Reference Values For T And B Lymphocyte Subpopulations In Turkish Children And Adults, Özge Besci̇, Di̇lek Başer, İsmai̇l Öğülür, Ayşe Cansu Berberoğlu, Ayça Kiykim, Tolga Besci̇, Asim Leblebi̇ci̇, Hülya Elli̇dokuz, Perran Boran, Eren Özek, Goncagül Haklar, Ahmet Oğuzhan Özen, Safa Bariş, Eli̇f Aydiner
Reference Values For T And B Lymphocyte Subpopulations In Turkish Children And Adults, Özge Besci̇, Di̇lek Başer, İsmai̇l Öğülür, Ayşe Cansu Berberoğlu, Ayça Kiykim, Tolga Besci̇, Asim Leblebi̇ci̇, Hülya Elli̇dokuz, Perran Boran, Eren Özek, Goncagül Haklar, Ahmet Oğuzhan Özen, Safa Bariş, Eli̇f Aydiner
Turkish Journal of Medical Sciences
Background/aim: Established reference values are critical for the interpretation of immunologic assessments. In particular, the proportion and absolute counts of T- and B- cell subpopulations are subject to change with age and ethnicity. We aimed to establish agespecific reference values for lymphocyte subsets using updated immunophenotyping panels. Materials and methods: We studied a total of 297 healthy Turkish subjects aged 0 to 50 years, stratified into major age brackets in a cluster factor of 10 per age-group. The predetermined age intervals contained randomly allocated participants enrolled over a period of 6 months, who were homogenously distributed by sex. We analyzed …
The Relationship Between Breast Milk Intake And Speech In Children With Cerebral Palsy, Gül Demet Kaya Özçora, Gonca Bektaş
The Relationship Between Breast Milk Intake And Speech In Children With Cerebral Palsy, Gül Demet Kaya Özçora, Gonca Bektaş
Turkish Journal of Medical Sciences
Background/aim: Cerebral palsy (CP) is a nonprogressive neurodevelopmental disorder that cause damage to the developing brain (0-3 years) for various reasons. Children with CP commonly have speech disorders due to impairment in neuromuscular control of oro-motor coordination. We focused on the relationship between breast milk intake and speech functions in children with CP. Materials and methods: The gross motor function classification system (GMFCS) was used to categorize the gross motor function. The viking speech scale (VSS) was used to classify the speech in children with cerebral palsy. Children were subdivided into two groups as term and preterm based on gestational …
Utilization Of Biotechnological Drugs In Rare Diseases Requiring The Use Of Off-Label Drugsin Children In Turkey, Neri̇man İpek Kirmizi, Volkan Aydin, Nari̇n Akici, Banu Bayar, Ahmet Akici
Utilization Of Biotechnological Drugs In Rare Diseases Requiring The Use Of Off-Label Drugsin Children In Turkey, Neri̇man İpek Kirmizi, Volkan Aydin, Nari̇n Akici, Banu Bayar, Ahmet Akici
Turkish Journal of Medical Sciences
Background/aim: Pediatric patients, especially those with rare diseases, represent a population that has a high tendency towards offlabel drug use (OLDU) and needs a more careful practice of pharmacotherapy than in adults. We aimed to investigate biotechnological drug use in children with rare diseases requiring OLDU. Materials and methods: This retrospective study examined all single-diagnosed OLDU applications (n = 5792) for 4992 children (
Can Patients Who Apply To Tertiary Care With Headache For The First Time Be Managed Inprimary Care? - A Cross-Sectional Study, Esra Hündür Doğan, İrfan Şencan, Hasan Doğan, Adem Özkara
Can Patients Who Apply To Tertiary Care With Headache For The First Time Be Managed Inprimary Care? - A Cross-Sectional Study, Esra Hündür Doğan, İrfan Şencan, Hasan Doğan, Adem Özkara
Turkish Journal of Medical Sciences
Background/aim: Headaches are one of the most common neurological symptoms. They adversely affect daily life, reduces the workforce, and have high health costs. Managing this symptom in primary care will free up secondary and tertiary health services to better treat patients who need follow-up by specialists. In the present study, we aim to show the rate at which this problem can be solved in primary care for patients who applied tertiary care services with a headache for the first time. Materials and methods: Our research is a cross-sectional study of 207 patients who applied to the neurology clinics for the …
Measurement Of Interscalene Space Volume In Diagnosis Of Thoracic Outlet Syndrome: Acadaver Study, Tevfi̇k Kaplan, Ayhan Cömert, Mehmet Ali̇ Güner, Hali̇l İbrahi̇m Açar, Gökçe Kaan Ataç, İbrahi̇m Tekdemi̇r, Serdar Han
Measurement Of Interscalene Space Volume In Diagnosis Of Thoracic Outlet Syndrome: Acadaver Study, Tevfi̇k Kaplan, Ayhan Cömert, Mehmet Ali̇ Güner, Hali̇l İbrahi̇m Açar, Gökçe Kaan Ataç, İbrahi̇m Tekdemi̇r, Serdar Han
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to measure the volume of interscalene space in thoracic outlet region on cadavers and radiological images and to analyze the potential value of these measurements in diagnosis and treatment of thoracic outlet syndrome (TOS). Materials and methods: The dimensions of the anterior interscalene space in 8 formalin-fixed human cadavers were studied by direct measurement and additionally evaluation of the volume of this space were done by using mold and volume calculation formula of square pyramid, due to resembling a pyramid. In the second phase of this study, interscalene space volume was calculated by …
A Randomized Comparison Between Ultrasound-Guided Costoclavicular Andinfraclavicular Block For Upper Extremity Surgery, Sevi̇m Cesur, Ahmet Murat Yayik, Ayşe Nur Daş, Ali̇ Ahiskalioğlu
A Randomized Comparison Between Ultrasound-Guided Costoclavicular Andinfraclavicular Block For Upper Extremity Surgery, Sevi̇m Cesur, Ahmet Murat Yayik, Ayşe Nur Daş, Ali̇ Ahiskalioğlu
Turkish Journal of Medical Sciences
Background/aim: This study compared ultrasound guided costoclavicular (CC) and lateral sagittal infraclavicular (LS) brachial plexus block in patients undergoing upper extremity surgery. Materials and methods: A total of 80 patients undergoing upper extremity surgery were randomly classified into two groups: Group CC (costoclavicular (n = 40)) and Group LS (lateral sagittal infraclavicular (n = 40)). Both groups received a 25 mL containing a mixture of 1% lidocaine and 0.25% bupivacaine. A blinded observer recorded the block onset time and decided which patients who were admitted to the operation room needed general anesthesia or rescue block or without any iv. narcotics …
Prognostic Value Of Oxygen Saturation And Heart Rate During A Six-Minute Walk Test Inpediatric Pulmonary Hypertension, Vi̇ldan Atasayan, Fatma Canbeyli̇, Fatma Sedef Tunaoğlu, Ayşe Deni̇z Oğuz, Bülent Çeli̇k, Serdar Kula
Prognostic Value Of Oxygen Saturation And Heart Rate During A Six-Minute Walk Test Inpediatric Pulmonary Hypertension, Vi̇ldan Atasayan, Fatma Canbeyli̇, Fatma Sedef Tunaoğlu, Ayşe Deni̇z Oğuz, Bülent Çeli̇k, Serdar Kula
Turkish Journal of Medical Sciences
Background/aim: To evaluate the pre and post-treatment heart rate and oxygen (O2 ) saturation values measured before, during and after 6MWT in children who received PAH-specific treatment and to determine the effect of these variables on prognosis. Materials and methods: This retrospective study included 29 patients who were diagnosed as PAH and treated. The transcutaneous O2 saturationand heart rate levels were recorded before the test: baseline (Sat0, HR0), at the end of the test: exercise (Sat1, HR1) and 5 min after the test: recovery (Sat2, HR2). The increase in heart rate was defined as HR1-HR0 and the decrease in saturation …
Association Between Active Pulmonary Tuberculosis And Circulating Micrornas: Apreliminary Study From Turkey, Fatma Kalayci Yüksek, Cenk Kiğ, Medi̇ha Gönenç Ortaköylü, Meltem Uzun
Association Between Active Pulmonary Tuberculosis And Circulating Micrornas: Apreliminary Study From Turkey, Fatma Kalayci Yüksek, Cenk Kiğ, Medi̇ha Gönenç Ortaköylü, Meltem Uzun
Turkish Journal of Medical Sciences
Background/aim: Tuberculosis is a public health problem that still remains significant. For prevention, diagnosis, and treatment of tuberculosis more effective novel biomarkers are needed. MicroRNAs can regulate innate and adaptive immune responses, alter host-pathogen interactions, and affect progression of diseases. The relationship between microRNA expression and active pulmonary tuberculosis (APT) has not yet been investigated in the Turkish population. We aimed to test the potential diagnostic value of some microRNAs whose levels were previously reported to be altered in APT patients. Materials and methods: Using two different references (U6 and miR-93), we compared the expression levels of potentially important microRNAs …
The Relationship Of Serum Visfatin Levels With Clinical Parameters, Flow-Mediateddilation, And Carotid Intima-Media Thickness In Patients With Ankylosing Spondylitis, Rabi̇a Aydoğan Baykara, Adem Küçük, Ayça Tuzcu, Göksel Tuzcu, Erkan Cüre, Ali̇ Uğur Uslu, Ahmet Omma
The Relationship Of Serum Visfatin Levels With Clinical Parameters, Flow-Mediateddilation, And Carotid Intima-Media Thickness In Patients With Ankylosing Spondylitis, Rabi̇a Aydoğan Baykara, Adem Küçük, Ayça Tuzcu, Göksel Tuzcu, Erkan Cüre, Ali̇ Uğur Uslu, Ahmet Omma
Turkish Journal of Medical Sciences
Background/aim: Atherosclerotic heart diseases can occur at an early age in patients with ankylosing spondylitis (AS). Flow-mediated dilation (FMD) and carotid intima-media thickness (cIMT) values are reliable markers for early detection of subclinical atherosclerosis in patients with AS. We aimed to investigate the relationship between visfatin levels and indirect markers of subclinical atherosclerosis and endothelial dysfunction in patients with AS. Materials and methods: Forty-two patients diagnosed with AS and 42 age, sex, and body mass index (BMI)-matched controls were included in the study. Visfatin levels, FMD, and cIMT were measured using appropriate methods. Results: Visfatin levels of the patients were …
The Prevalence Of Sjögren's Syndrome And Sicca Symptoms In Patients With Systemicsclerosis And Alpha-Smooth Muscle Actin Expression In Biopsy Specimens From Minorsalivary Glands, Gerçek Can, Sülen Sarioğlu, Ahmet Meri̇h Bi̇rli̇k, Gökçe Kenar, Özgül Soysal Gündüz, Di̇lek Solmaz, Vedat Gerdan, Fatoş Önen, Nurullah Akkoç, Servet Akar
The Prevalence Of Sjögren's Syndrome And Sicca Symptoms In Patients With Systemicsclerosis And Alpha-Smooth Muscle Actin Expression In Biopsy Specimens From Minorsalivary Glands, Gerçek Can, Sülen Sarioğlu, Ahmet Meri̇h Bi̇rli̇k, Gökçe Kenar, Özgül Soysal Gündüz, Di̇lek Solmaz, Vedat Gerdan, Fatoş Önen, Nurullah Akkoç, Servet Akar
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the prevalence of sicca symptoms and secondary Sjögren's syndrome (SjS) in patients with systemic sclerosis (SSc). Also this study aimed to evaluate the expression of ∝ -smooth muscle actin (∝ -SMA) in minor salivary gland (MSG) specimens, a possible marker of fibrosis responsible for myofibroblastic transformation. Materials and methods: Patients with SSc who were followed in Rheumatology outpatient clinic at a university hospital evaluated. The questionnaire of sicca symptoms and classification of SjS were evaluated according to the American-European Consensus Group (AECG) criteria. Histopathologic evaluations were done in MSG specimens investigating the presence of …
The Alteration Of Lymphocyte Subsets In Idiopathic Granulomatous Mastitis, Ayça Emsen, Hande Köksal, Hülya Uçaryilmaz, Nai̇m Kadoglou, Hasi̇be Artaç
The Alteration Of Lymphocyte Subsets In Idiopathic Granulomatous Mastitis, Ayça Emsen, Hande Köksal, Hülya Uçaryilmaz, Nai̇m Kadoglou, Hasi̇be Artaç
Turkish Journal of Medical Sciences
Background and aim: This study analyzed peripheral blood lymphocyte subsets to determine their role in the etiopathogenesis of IGM. Materials and methods: This study includes 51 pathologically proven IGM patients (active disease: 26 and in remission: 25) and 28 healthy volunteers. The analyses of lymphocyte subsets were performed by flow cytometric immunophenotyping. Results: The percentage of T helper lymphocyte of all IGM patients were lower than control groups (p = 0.001). Absolute cytotoxic T lymphocyte count (p = 0.03), both percentage (p = 0.035) and absolute count (p = 0.002) of the natural killer cells, and both percentage (p = …
The Contribution Of Postnatal Steroid Administration To Early Brain Damage In Pretermbabies With Bronchopulmonary Dysplasia, Sabahatti̇n Ertuğrul, Savaş Mert Darakci̇, İbrahi̇m Kaplan, İlyas Yolbaş, İbrahi̇m Deger, Si̇bel Tanriverdi̇ Yilmaz, Şerafetti̇n Aktaş
The Contribution Of Postnatal Steroid Administration To Early Brain Damage In Pretermbabies With Bronchopulmonary Dysplasia, Sabahatti̇n Ertuğrul, Savaş Mert Darakci̇, İbrahi̇m Kaplan, İlyas Yolbaş, İbrahi̇m Deger, Si̇bel Tanriverdi̇ Yilmaz, Şerafetti̇n Aktaş
Turkish Journal of Medical Sciences
Background/aim: Postnatal corticosteroids are commonly used to treat bronchopulmonary dysplasia (BPD). We aimed to show whether S100 calcium-binding B (S100B), neuron-specific enolase (NSE), Tau protein or microtubule-associated protein tau (MAPT), and glial fibrillary acid protein (GFAP) levels would provide any evidence of early neurological damage in premature infants receiving postnatal low dose dexamethasone therapy for BPD treatment. Materials and methods: In this cohort study, 136 preterm infants diagnosed with BPD at ≤ 32 weeks of gestation formed the study group, and 64 preterm infants formed the control group. NSE, S100B, GFAP, and MAPT levels were first measured before the postnatal …
The Relationship Between Amount Of Extra-Prostatic Extension And Length Of Capsularcontact: Performances From Mr Images And Radical Prostatectomy Specimens, Aslihan Onay Çolak, Bariş Bakir
The Relationship Between Amount Of Extra-Prostatic Extension And Length Of Capsularcontact: Performances From Mr Images And Radical Prostatectomy Specimens, Aslihan Onay Çolak, Bariş Bakir
Turkish Journal of Medical Sciences
Backround/aim: In prostate cancer, extraprostatic extension (EPE) is an unfavorable prognostic factor, and the grade of EPE is correlated with the prognosis. This study aims to evaluate the utility of length of capsular contact (LCC ) in predicting the grade of EPE by correlating the measurements from MRI images and the measurements performed from radical prostatectomy specimens. Materials and methods: MR images and specimens of 110 tumors are analyzed retrospectively. The specimens are used as reference to validate the presence of EPE and to measure the ground truth LCC. MR images are evaluated by two radiologists to identify the presence …
Nephrological Factors May Cause Kidney Dysfunction In Patients With Common Variableimmunodeficiency, Gökhan Ayteki̇n, İsmai̇l Baloğlu, Fati̇h Çölkesen, Eray Yildiz, Şevket Arslan, Külti̇gi̇n Türkmen
Nephrological Factors May Cause Kidney Dysfunction In Patients With Common Variableimmunodeficiency, Gökhan Ayteki̇n, İsmai̇l Baloğlu, Fati̇h Çölkesen, Eray Yildiz, Şevket Arslan, Külti̇gi̇n Türkmen
Turkish Journal of Medical Sciences
Background/aim: Common variable immunodeficiency (CVID) is a heterogeneous primary deficiency characterized by hypogammaglobulinemia, recurrent infections, an increased risk of autoimmune disease, malignancy, and chronic inflammation. Proteinuria is one of the most important prognostic factors causing progression in kidney disease. Proteinuria causes tubulotoxicity, activates inflammatory markers that cause fibrosis, and consequently nephropathy progression. The data is scant in the literature regarding the inflammation and nephropathy in CVID. Hence, in the present study, we aimed to investigate the relationship between tubular dysfunction, proteinuria, and inflammation in patients with CVID. Materials and methods: This was a cross-sectional study involving 27 patients with CVID …
Effectiveness Of Mepolizumab Therapy On Symptoms, Asthma Exacerbations, Steroiddependence, And Small Airways In Patients With Severe Eosinophilic Asthma, İnsu Yilmaz, Saki̇ne Nazi̇k Bahçeci̇oğlu, Murat Türk, Nuri̇ Tutar, Gülden Paçaci Çeti̇n, Bahar Arslan
Effectiveness Of Mepolizumab Therapy On Symptoms, Asthma Exacerbations, Steroiddependence, And Small Airways In Patients With Severe Eosinophilic Asthma, İnsu Yilmaz, Saki̇ne Nazi̇k Bahçeci̇oğlu, Murat Türk, Nuri̇ Tutar, Gülden Paçaci Çeti̇n, Bahar Arslan
Turkish Journal of Medical Sciences
Background/aim: The efficacy of mepolizumab has been largely demonstrated in clinical trials in patients with severe eosinophilic asthma (SEA). However, reports on experience with mepolizumab in a real-life cohort are limited. Moreover, data about the effectiveness of mepolizumab on small airways is scarce. This study evaluated the effectiveness of mepolizumab therapy on symptoms, asthma exacerbations, blood eosinophils, steroid dependence, and small airways in a real-life cohort of patients with SEA. Materials and methods: We retrospectively analyzed patients with SEA who were receiving fixed-dose mepolizumab. The effects of mepolizumab on clinical, laboratory, functional parameters were evaluated at 12th, 24th, and 52nd …
Tendon Of Flexor Carpi Radialis In Carpal Tunnel: A Radiologic And Cadaveric Study, Burcu Erçakmak Güneş, Alper Vatansever, Mehmet Deni̇z Demi̇ryürek, Kadri̇ye Mi̇ne Ergun, Mehmet Hakan Özsoy
Tendon Of Flexor Carpi Radialis In Carpal Tunnel: A Radiologic And Cadaveric Study, Burcu Erçakmak Güneş, Alper Vatansever, Mehmet Deni̇z Demi̇ryürek, Kadri̇ye Mi̇ne Ergun, Mehmet Hakan Özsoy
Turkish Journal of Medical Sciences
Background/aim: Carpal tunnel is an important anatomical passage that carries the flexor tendons into the hand. As there is still no consensus about its contents among the anatomy textbooks, the main purpose of this study was to identify the relations of the flexor carpi radialis tendon in the carpal tunnel. Materials and methods: This retrospective study was completed in April 2018 at authors' university's hospital. Seventy-four female and 44 male patients' wrists without any pathology were examined by using magnetic resonance images. The series of axial sections where the pisiform exist were evaluated by using T1 sequence and the structures …
The Prevalence Of Complementary And Alternative Medicine Use Among Turkish Patientswith Primary Headache, Büşra Sümeyye Arica Polat, Ayşe Çağlar Sarilar
The Prevalence Of Complementary And Alternative Medicine Use Among Turkish Patientswith Primary Headache, Büşra Sümeyye Arica Polat, Ayşe Çağlar Sarilar
Turkish Journal of Medical Sciences
Background/aim: The use of complementary and alternative medicine (CAM) is common in patients with primary headache. However, no study has been reported in which standardized modalities were questioned in a Turkish population. The aim of the present study was to investigate the frequency of CAM use and factors related to it in these patients. Materials and methods: Patients with a diagnosis of primary headache were included in this cross-sectional observational study. Demographic and disease specific characteristics were recorded. The use and effect of 15 CAM modalities were evaluated in accordance with the Traditional and Complementary Medicine Regulations. The patients were …
Investigation Of Oxidative Stress Status In Cumulus Cells In Patıents With In Vitrofertilization, Rabi̇a Tural, Cengi̇z Karakaya, Mehmet Erdem, Zeynep Aykol, Recep Onur Karabacak, Mustafa Kavutçu
Investigation Of Oxidative Stress Status In Cumulus Cells In Patıents With In Vitrofertilization, Rabi̇a Tural, Cengi̇z Karakaya, Mehmet Erdem, Zeynep Aykol, Recep Onur Karabacak, Mustafa Kavutçu
Turkish Journal of Medical Sciences
Background/aim: The negative impact of oxidative stress on oocytes obtained from in vitro fertilization (IVF) patients is a challenge for the optimization of live birth rates. In this study, it is aimed to investigate whether oxidant/antioxidant parameters have a predictive value in terms of determining the count and quality of oocytes. Materials and methods: Catalase (CAT), glutathione-S-transferase (GST), arylesterase (ARE) enzyme activities, and malondialdehyde (MDA) levels were analysed in cumulus cells of poor responder (n = 28, oocyte count ≤ 4), normo responder (n = 48, 5 ≤ oocyte count ≤ 14), and high responder (n = 26, oocyte count …
Mid-Term Results Of Total Hip Arthroplasty With Subtrochanteric Z-Osteotomy In Crowetype 3-4 Developmental Hip Dysplasia, Vedat Bi̇çi̇ci̇, İzzet Bi̇ngöl, Tamer Sazak
Mid-Term Results Of Total Hip Arthroplasty With Subtrochanteric Z-Osteotomy In Crowetype 3-4 Developmental Hip Dysplasia, Vedat Bi̇çi̇ci̇, İzzet Bi̇ngöl, Tamer Sazak
Turkish Journal of Medical Sciences
Background/aim: Total hip arthroplasty (THA) is technically more difficult and has higher complication rates in patients with Crowe type 3-4 developmental dysplasia of the hip (DDH). Due to the difficulties and different treatment options, there is still no consensus on the optimal treatment. We aimed to evaluate the mid-term results of our patients who had undergone subtrochanteric femoral shortening Z-osteotomy. Materials and methods: This study included 37 hips of 29 patients with the diagnosis of Crowe 3-4 DDH between June 2010 and December 2016 and who underwent femoral shortening Z-osteotomy with cementless total hip arthroplasty. Acetabular component was determined according …
Serum Growth Differentiation Factor-15 Analysis As A Malnutrition Marker Inhemodialysis Patients, Di̇dem Turgut, Deni̇z İlhan Topcu, Cemi̇le Cansu Alperen, Sidika Esra Baskin
Serum Growth Differentiation Factor-15 Analysis As A Malnutrition Marker Inhemodialysis Patients, Di̇dem Turgut, Deni̇z İlhan Topcu, Cemi̇le Cansu Alperen, Sidika Esra Baskin
Turkish Journal of Medical Sciences
Background/aim: Growth differentiation factor (GDF)-15 is related to inflammation and mortality in many conditions. We aimed to determine if an elevated serum GDF-15 level is related to nutritional status of patients on hemodialysis (HD) and mortality. Materials and methods: Routine HD patients (n = 158) were included in the study and followed for 18 months. Some malnutrition/ inflammation scoring indexes (malnutrition/inflammation score (MIS), controlling nutritional status (CONUT) score, and prognostic nutritional index (PNI)), biochemical parameters, and GDF-15 were used to build Cox regression multivariate models to study the association with mortality. Results: Among the patients, 90 (57 %) had a …