Biomedical Devices and Instrumentation Commons^™

Development Of A Light-Based Platform To Assess Cervical Mucus Barrier Function And Physical Mucus Properties, Elizabeth J. Buzbee

McKelvey School of Engineering Graduate Student Theses & Dissertations

Preterm birth is the leading cause of neonatal morbidity and mortality worldwide, yet current clinical tools for predicting its risk lack specificity and reliability. Cervical mucus plays a crucial role in maintaining pregnancy by forming a barrier that protects the uterus against infection. This study investigates the use of laser speckle rheology as a noninvasive technique to assess cervical mucus biomechanics. Synthetic cervical mucus was fabricated at varying hydration levels and tested using a conventional rheometer that confirmed that the mechanical properties of the synthetic mucus samples were representative of physiological cervical mucus. These results were compared to the complex …

Opmed Seal: Engineering A Rapid-Response Biodegradable Device For Hemorrhage Control And Infection Prevention In Abdominal Trauma, Paula M. Cabrera, Wesley Stephen Murphy

Honors Theses

Abdominal gunshot wounds are amongst the deadliest injuries encountered in combat and remote emergency settings. For military medics and first responders, the challenge lies in controlling internal bleeding and preventing infection before patients can reach surgical care-often within a narrow window of time known as the “golden hour”. Currently available field treatments are either too slow, not designed for internal wounds, or fail to provide antimicrobial protection. To address this gap, our team developed OpMed Seal: a compact, dual-syringe delivery system that deploys a biodegradable, antibiotic-infused hydrogel directly into abdominal injuries. The system is designed for rapid hemorrhage control, localized …

Design And Development Of A Stethoscope Attachment For Instant Heart Murmur Detection, Caitlin K. Cherwin, Dillon Desai

Honors Theses

Heart murmurs are critical indicators of potential cardiovascular conditions yet their detection can often go unnoticed due limitations in equipment and is dependent on clinician experience. Cardiovascular disease remains a leading cause of death worldwide, therefore, early detection of heart murmurs play a crucial role in improving patient outcomes. Many established methods of detection are expensive and often unreliable allowing there to be room for a device which is more cost and result effective. This paper presents the development of a device that attaches onto a regular stethoscope and analyzes auscultatory sounds to diagnose the possibility of a present murmur. …

Using Deep Learning And Two-Photon Excitation Fluorescence Microscopy To Predict Breast Cancer Recurrence And Response To Chemotherapy, Nicholas Powell

Graduate Theses and Dissertations

Accurate prediction of breast cancer recurrence plays a critical role in guiding treatment decisions, particularly regarding the use of systemic therapy for patients. While genomic assays such as the Oncotype DX Recurrence Score offer valuable prognostic information, they are limited in accessibility and application. The work presented in this thesis explores an imaging-based approach for the prediction of breast cancer recurrence that combines multiphoton microscopy (MPM) with deep learning to classify individual breast cancer biopsy samples by risk of recurrence. Genomic differences in tumors with different recurrence potentials may translate to distinct optical and structural information that can be captured …

Efficacy Of Mitophagy Inhibition As A Potentiating Agent For Conventional Chemotherapy, Morghan Relich, Shelby Bess

Biomedical Engineering Undergraduate Honors Theses

Cancer is a result of uncontrolled growth and reproduction of cells. Damaged or abnormal cells grow and multiply when they should not and in turn the cells continue to proliferate and metastasize. Malignant cells rely on functional mitochondria for proliferation, metastasis, and survival. These mitochondria maintain a functional mitochondrial network through a quality control mechanism called mitophagy. Mitophagy is a conserved intracellular process to maintain quality control and remove damaged mitochondria.

Previous research has been done to examine the effects of mitophagy in tumor cells, as well as the effects of mitophagy inhibition. One focus of current research has been …

Design And Evaluation Of Antibody-Conjugated Microneedle Patch For Early Mrsa Biomarker Detection, Kylee Marie Pop, Alexis Richie, Nicholas Jenkins, Andrew Holmes

Honors Theses

Post-operative orthopedic surgical site infections (SSIs), specifically those caused by methicillin resistant Staphylococcus aureus (MRSA), present a significant clinical challenge due to delayed detection, increased morbidity, and current rising healthcare costs. Early detection of infection remains limited due to the current methods of diagnosis, which consist of observation of the surgical site and laboratory infrastructure for conformation of infection. To combat these issues, my team and I have designed and evaluated a minimally invasive microneedle diagnostic patch that continuously monitors for the presence of MRSA-associated biomarker PBP2a in interstitial fluids around surgical site incisions. Upon antigen detection, a colorimetric response …

Impact Of Shear Flow On Marine Biofilms Using Hyperspectral Imaging, Shantanu Mahesh Kore

All Theses

Various microbial communities in marine biofilms cause biofouling on submerged surfaces, posing challenges to marine industries. Despite their ecological and economic importance, biofilms' biomechanical and biochemical responses to hydrodynamic shear stress are insufficiently understood, particularly in dynamic flow conditions. To fill this gap, our study uses an innovative fiber-optic hyperspectral imaging (HSI) system and a supercontinuum laser source to examine marine biofilms' structure, composition, and detachment behavior at different shear stress levels.

To detect spectral and spatial heterogeneity in live biofilms without labeling, we created a custom imaging pipeline that captures reflectance spectra in the 600-850 nm range, targeting microbial …

Development Of A Portable Electroencephalogram With Display, Seth D. Davis

Electronic Theses and Dissertations

In this experiment, the goal was to design, build, and test an Electroencephalogram (EEG) circuit that would then be paired with a touchscreen display as a portable unit for use in Schizophrenic research at East Tennessee State University at the Quillen College of Medicine. The requirements for this prototype denoted that the device had to be able to obtain a signal from two electrodes placed on the head of an individual with a third attached to the ankle as a ground, amplify and filter the signal, and display the results on a touchscreen display for recording and analyzing. The circuit …

Applying Residence Time Distribution Theory To Coronary Thermodilution Curves., Jacob Michael Miller

Electronic Theses and Dissertations

Cardiovascular diseases remain the leading cause of death worldwide and coronary microvascular dysfunction is one cardiovascular disease which is particularly challenging to diagnose and treat. Coronary thermodilution is a widely used, invasive procedure to evaluate microvascular function by generating physiological indices such as coronary flow reserve and the index of microvascular resistance. Although commonly cited as an indicator dilution method in the cardiovascular literature, current coronary thermodilution techniques lack rigorous application of the accompanying mathematical framework, thereby leaving potentially valuable diagnostic information unexploited. This study bridges that gap by demonstrating the equivalence between indicator-dilution theory and residence time distribution theory …

Development Of Translational Microscale Systems To Interrogate How Biophysical And Biochemical Cues Alter The Phenotype Of Hormone Positive Breast Cancer, Braulio Ortega Quesada

All Dissertations

Cancer is a complicated disease and one in every three diagnoses are women with breast cancer. Recent research shows that the progression of cancer depends strongly on interactions with other non-cancerous cells and non-cellular components. Metastasis, the spread of cancer to other parts of the body, is a key step in cancer progression and makes treatment harder, leading to poor response to treatments culminating in death in ~90% of patients. This dissertation focused on creating a series of microdevices as novel pre-clinical models of breast cancer. Two different devices were fabricated to (1) study how exposing cancer cells to the …

Cruising On The Beach (Cob), Juan Diego Molina Ii, Ashley Kianna Burga

Biomedical Engineering

This report details the design and development process of Cruising on the Beach (COB), a modular motorized wheelchair intended to improve beach accessibility for high school students with mobility impairments. The project aimed to create an affordable, portable, and sand-capable device using balloon wheels, an adjustable control panel, and a customizable base. Extensive background research, market analysis, design modeling, and test plans were completed. However, final fabrication was not achieved due to financial constraints and limited access to industrial machining tools needed for custom metal components. Despite these setbacks, the project delivered a robust conceptual design and a fully …

Providing A Solution For Active-Duty Servicewomen Facing Chronic Musculoskeletal Injuries Due To Improper Gear Fit, Celia Watson, Denver Tidwell, Hadi Obaji

Honors Theses

As senior biomedical engineering students at the University of Mississippi, we began our academic year brainstorming unmet clinical needs in healthcare intending to provide an innovative solution. After conducting personal inventories, determining a mission, and evaluating internal and external factors, we established acceptance criteria for our strategic focus and clarified our needs statement: develop a prophylactic device for chronic musculoskeletal injuries (MSKIs) in active-duty servicewomen (ADSW). The average female soldier is at a disadvantage compared to her male counterpart due to anthropometric and physiological differences between men and women in most aspects of physical performance (Epstein et al. 2673). These …

Evervital Patch: The Design And Development Of A Continuous Cardiac Monitoring Device For Post-Operative, In-Hospital Patients, Abigail Moeller, Jonathan Seid

Honors Theses

In the United States, due to the increasing prevalence of cardiovascular disease, over 900,000 cardiac surgeries are performed annually, with projections exceeding 1.3 million by 2029. Many post-surgical patients require continuous in-hospital cardiac monitoring, which is typically conducted using electrocardiograms (EKGs). However, traditional EKG systems such as bedside cardiac monitors and cardiac telemetry monitors rely on wired leads that can easily tangle, degrade signal quality, and require frequent readjustments or replacements due to wire breakage, and for the patient, this can cause discomfort from prolonged use. To overcome these challenges, our company, CardioSync, aims to develop a wireless cardiac monitoring …

Limbgod(Pat. Pending): Wearable Garment For Amputation Prevention, Naomi Choi Dpm, Mba, Phuc An Dinh Bs, Ms, Eric Lee Bs, Francois M. Lokenye Dpm

Posters

Approximately 1.6 million people in the U.S. have lower limb amputations, which is expected to double by 2050 (Wong et al.). Socio-economic factors: income, education, rural residency & race, impact amputation risk (Okesina et al.), with Black Americans 70% are more likely to undergo major lower limb amputations than white Americans, even after adjusting for care access & comorbidities (Feinglass et al., Holman et al., Regenbogen et al.). Within 5 years, up to 50% of first-time amputees require another amputation (Dilingham et al., Glaser et al.) & those with comorbidities face a 77% five-year mortality rate (Fortington et al.).

Clinical Use Of Sit2stand Ai Application For Kinematic Analysis In Prosthesis Users., Samerial Brown

Posters - 2025

Biomechanical analysis is a tool to evaluate prosthetic and orthotic patient's. These tools offer the clinician capability of understanding the mechanism of injury, gait deviation or prosthesis problem. Video based analysis require expensive hardware, software, and training which sometimes costs $40-100,000.

The recent advent of artificial intelligence (AI) has opened up the possibility of acquiring high speed human motion video analysis using low-cost hardware and open-source machine learning algorithms. Still, free assessments like the Sit2Stand test is a current clinical outcome measure which assesses ability of a patient to stand and sit as fast as possible 5x. The faster the …

Next-Generation Biomedical Implants And Stimuli Responsive Soft Optical Arrays Via Surface Functionalized Elastomeric Materials, John M. Kapitan

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

The demands of emerging technologies, such as soft robotics, stretchable electronics, and next generation biomedical implants, has led to the development of diverse polymeric and hybrid organic/inorganic materials specifically tuned to meet these challenges. These materials typically have low Young’s moduli and are inert with high chemical stability. However, this has led to materials that are static in nature, lacking any meaningful way of responding to changes in their environment and adapting to these changes. This has driven a shift towards the design, manufacturing, and characterization of various stimuli responsive surfaces, relying on precise control of surface chemical coatings and …

Development, Optimization, And Validation Of A High-Sensitivity Capillary Zone Electrophoresis System For Bioanalytical Applications, Aaron I. Mena

Electronic Theses and Dissertations

Capillary zone electrophoresis (CZE) is a powerful analytical technique widely used for biomolecular separation due to its high resolution, efficiency, and sensitivity. This report presents the development and validation of a novel CZE system designed to improve modularity, reproducibility, and operational efficiency. The system integrates a laser-induced fluorescence (LIF) detection method with a 488 nm laser, enhanced fluid control through a negative pressure system, and a user-friendly GUI for automated operation and data acquisition. Performance verification included pressure stability tests, fluorescence accuracy assessments, and electrophoretic reproducibility studies. Comparative analysis with a previous CZE iteration confirmed improved baseline stability, peak resolution, …

Realistic Bionic Arm Development For Transradial Amputation, Bailey A. Wall, Lilly Noel Curdy, Ruthie Mccall, Courtney Mahoney, Andres Trejo

Biomedical Engineering

The VeraLimb realistic bionic arm is intended for use by individuals with a trans-radial amputation or congenital limb deficiency below the elbow to provide functional hand and arm movements. This advanced prosthetic device is designed to mimic a biological hand's natural motion, dexterity, control, and aesthetic, giving the user a higher sense of restored limb functionality. It offers an experience that closely restores motor function in a way that resembles having a natural hand rather than interacting with a mechanical device. The VeraLimb is suitable for daily activities, allowing users to grasp, manipulate, and interact with objects. It is designed …

Operating Room Forcing Function, Olivia Rankin, Makena Moragne, Sasha Rovinsky

Biomedical Engineering

The Operating Room Forcing Function system aims to address the persistent issue of wrong-site, wrong-procedure, and wrong-patient errors (WSPEs) in surgical settings. WSPEs are largely caused by circumvention of the timeout procedure (a planned pause before incision to stop and confirm crucial details of the procedure to be performed known as ‘The Universal Protocol’). The goal set forth by our sponsor, Dr. Robert Turbow, is to develop a lock-out mechanism that requires a timeout to be performed by all appropriate personnel before an operation can begin.

Hospitals are extremely complex systems with competing values, productivity pressures, fast paced work, tight-coupled …

The Suture Guide, Nicole Schnettler, Ciara Murphy, Jocelyn Corona Cabrera

Biomedical Engineering

In the surgical field and specifically wound closure, there is a growing demand for techniques that allow surgeons to quickly, accurately, and ergonomically close surgical wounds while still optimizing patient recovery and not compromising the cosmetic appearance in wound closure. Currently more advanced and developed products exist for laparoscopic suturing, but not for superficial suturing. This project aims to find a way to close the most superficial layer of the skin in surgical incisions that is faster and more comfortable than current suturing techniques. The design process began with stakeholder interviews and market research, identifying key shortcomings of current manual …

Unified Adaptive Cross-Attention Multimodal Network, Mahesh Sunuwar

Shelby Hall Graduate Research Forum Posters

Accurately diagnosing appendicitis remains a significant challenge in emergency medicine due to its varied clinical presentation and overlap with other abdominal conditions. Existing diagnostic models often rely on unimodal data, such as computed tomography (CT) images or clinical notes, limiting their ability to capture the full complexity of patient information. This study proposes a novel multimodal framework, a Unified Adaptive Cross-Attention Multimodal Framework (u-ACM), that integrates CT images and clinical notes using hybrid fusion strategies to improve diagnostic accuracy for appendicitis. The u-ACM leverages adaptive contextual filtering to dynamically remove irrelevant features, crossattention mechanisms to align features between modalities, and …

Tiny Temp Neonatal Intensive Care Unit Infant Temperature Monitor, Alexandria Lukacsffi, Sydney Dedrick

Biomedical Engineering

This document outlines the key steps taken in the specification, design, and functionality of the Tiny Temp Neonatal Intensive Care Unit Infant Temperature Monitor. The BICEP team identified temperature monitors for infants in incubators in the NICU as an area of need after surveying hospitals in the San Luis Obispo area. Current thermometers are oversimplified in design, consisting of only the temperature probe and a piece of adhesive holding the probe directly onto the infant's skin. As a result, the adhesive is weak to prevent harm to the infant and, therefore, falls off the infant easily and frequently, posing a …

Peripheral Vagus Nerve Stimulation (Pvns) Device For Epilepsy, Logan P. Beckstrand, Alexander P. Crary, Grace E. Heller

Biomedical Engineering

Our research team developed a PVNS for Epilepsy device which is intended to act as a preventative measure against seizures for patients with epilepsy. The device is a less invasive alternative to the VNS device on the market using electroacupuncture at the Shenmen and Xin points along the posterior pinna to stimulate the vagus nerve.

Sprinter Start Block Training Aid, Kayla Lovejoy, Kevin Almontes

Biomedical Engineering

Currently, track and field sprinters ranging from beginner level to world-class have no practical tool that provides quantitative feedback of value on quality of start and quality of the three distinct phases of their sprint race, such that they can quantify the value of their adjustments. Our team will create a device that integrates with the sprint starting block to provide quantifiable data on the quality of a sprinter’s start. This Statement of Work describes drawbacks of current solutions, existing patents, customer requirements, engineering specifications, and our project plan.

Identifying Breathing, Swallowing, And Speech Biosignatures In Parkinson’S Disease Patients With Wearable Devices, Amanda Brandaris, Katherine Shishido, Rohaan Manzoor, Ethan Hampton, Karthik Jasty, Kelvin Guo, Anna Fish, Spencer Peterson, Ulrike H. Mitchell Phd, Phillip Sechtem Phd, Ccc-Slp, Paula Johnson Phd, Anton E. Bowden Phd, Miriam Cortez-Cooper Pt, Phd, Pamela I. Barney Msrt, Rrt, Ae-C, Nps, John A. Kriak Pharmd

Annual Research Symposium

No abstract provided.

Advancing Prosthetic Technology: 3d-Printed Robotic Arm With Micro Linear Actuators, Vu Tran, Nathan Reed, Mahdi Yazdanpour

Posters-at-the-Capitol

The increasing demand for affordable and accessible prosthetic solutions has driven innovation in the field of robotics. In this project, we present the design and development of a 3D-printed robotic prosthetic arm aimed at addressing the challenges faced by individuals with upper limb amputations. Our prosthetic arm utilizes five micro linear actuators to achieve precise and naturalistic movement. The design of the prosthetic arm prioritizes affordability and accessibility, with a focus on leveraging 3D printing technology to reduce manufacturing costs and enable customization. The use of micro linear actuators offers advantages in terms of compactness, lightweight construction, and efficient power …

Adaptation Of The Biodent For Spherical Microindentation To Determine Elastic Modulus In Small Rodent Bones, Mixame E. Jerome

Dissertations and Theses

Mechanical and material properties of bone are essential for understanding both normal skeletal function and the progression of bone-related diseases. Microindentation has become a widely used method for evaluating tissue mechanical properties of bone, as it samples the contributions of microarchitecture and composition. Microindentation using a standard pointed tip inherently introduces both elastic and plastic deformation into the material. In contrast, indentation with a spherical tip can be operated entirely in the elastic range, providing for a non-damaging test that has significant advantages over sharp indentation techniques. Moreover, a key advantage of using spherical indentation lies in its operation under …

Advancing Electrical Stimulation: Full-Head Mri Segmentation For Abnormal Brain Anatomy With Tdcs, Andrew Birnbaum

Dissertations and Theses

Evaluating the effectiveness of transcranial direct current stimulation (tDCS) is essential for guiding its integration into therapeutic and performance-enhancement applications. In our laboratory, we investigate the efficacy of tDCS across multiple experimental models, including both animal and human studies. I have contributed significantly to the execution and analysis of these experiments, which include studies in rats and healthy human participants aimed at evaluating whether electrical stimulation of the motor cortex can enhance motor learning. These studies assess improvements in fine motor performance resulting from tDCS. In stroke patients, I contribute to our investigation of tDCS as a rehabilitative intervention, particularly …

Viscoelastic Property Analysis Of A Magnetorheological Elastomer Micropump For Insulin Delivery In Type 1 Diabetes, Victor Buitimea

College of Graduate Studies: Theses & Dissertations

Over two decades, there has been a significant rise in awareness regarding Type 1 Diabetes (T1D), leading to a deeper comprehension of numerous variables, including hereditary factors, patterns of occurrence, and health challenges. According to the Type 1 Diabetic Index, around 8.7 million people worldwide are affected by this chronic autoimmune illness marked by a lack of insulin and hyperglycemia. The introduction of artificial pancreas systems could save more than half a million patients by 2040. Despite the availability of various insulin delivery technologies that are offered to diabetic patients, many still are skeptical of this modern system. The issues …

Development And Clinical Validation Of The Sensor-E Exoskeleton For Objective Hand Function Assessment In Stroke Rehabilitation, Madison Bates

Theses and Dissertations--Biomedical Engineering

Hand function is often impaired following neurological trauma or in conditions such as stroke, limiting independence and the ability to perform activities of daily living (ADLs). Current clinical assessments rely heavily on subjective rating scales that lack the resolution to detect subtle changes in motor performance, which can limit access to rehabilitation. Recent advances in wearable technologies highlight the potential for hand-worn devices to provide objective, real-time measures of hand function. However, most systems focus solely on kinematics and rarely capture both movement and exerted force. Moreover, integration into rehabilitation frameworks and brain-computer interface (BCI) protocols remains limited. To address …