Biomedical Devices and Instrumentation Commons^™

Comparative Analysis Of Takagi-Sugeno And Mamdani Fuzzy Inference Architectures With Anfis-Based Automated Rule Generation For Eeg-Based Cognitive State Monitoring, Amina Radončić, Mehrija Hasičić, Jasmin Kevrić

Communications of the IIMA

Fuzzy inference systems have demonstrated considerable promise for EEG-based cognitive state monitoring in neurodegenerative conditions. However, two design decisions significantly influence system performance and clinical applicability: the choice of inference architecture (Takagi-Sugeno vs Mamdani) and the method of rule and membership function generation (manual expert-driven vs data-driven automated). This paper presents a comparative analysis of both dimensions in the context of an EEG-based Alzheimer’s disease monitoring system operating on the ds004504 OpenNeuro dataset (88 subjects: 36 AD, 23 FTD, 29 HC). A Takagi-Sugeno system, implemented as a hybrid FSM-Fuzzy architecture, is compared against a Mamdani equivalent across four axes: inference …

Research On Development Strategy Of China’S High-End Medical Device Industry, Liu Zhihong, Hui Zhu, Wei Wu, Jiani Li, Yingke Xu, Jianxin Zhang

Bulletin of Chinese Academy of Sciences (Chinese Version)

High-end medical device industry serves as a critical technological foundation for modern healthcare systems and represents an important indicator of a country’s innovation capacity, advanced manufacturing capability, and industrial governance effectiveness. Amid intensifying global technological competition, upgrading healthcare demands, reshaping regulatory regimes and restructuring global supply chains, promoting the high-quality development of the high-end medical device industry has become essential for enhancing indigenous innovation capacity and ensuring industrial security. This study examines international experiences from the United States, Germany, Japan, and other countries in innovation ecosystem development, regulatory review optimization, market payment incentives, participation in international rules, and governance of …

Development And Preliminary Pressure Control Validation Of Woundwatch: Npwt System With Remote Monitoring Capabilities, Swetha Senthil Nathan

The Cardinal Edge

Chronic wounds, including diabetic foot ulcers, pressure sores, and venous leg ulcers, affect over 40 million individuals worldwide and are often complicated by delayed healing due to limited access to continuous monitoring. Negative Pressure Wound Therapy (NPWT) is an established treatment that promotes wound healing through controlled sub-atmospheric pressure. However, conventional NPWT systems lack real-time physiological feedback and require frequent in-person follow-ups, limiting their effectiveness in remote or low-resource settings. This study presents WoundWatch, a portable, low-cost NPWT device that integrates real-time temperature, humidity, and pressure sensing with wireless data transmission via an IoT platform. The system includes a vacuum …

Pid Control For Lower Limb Exoskeletons: A Framework Evaluation, Javlonbek Rakhmatillaev, Vytautas Bučinskas

Chemical Technology, Control and Management

This research provides a detailed guideline for implementing and evaluating Proportional Integral Derivative (PID) control frameworks in lower limb rehabilitation exoskeleton robotics. It examines the role of control systems within rehabilitation robotics, outlines the principles of PID control, describes exoskeleton architecture, explores applications of PID control, reviews optimization strategies, presents experimental validations, and considers future developments in the field. The proposed control framework incorporates aspects of mechanical design, actuator and sensor selection, and PID-based control algorithms, thereby promoting safe, accurate, and individualized rehabilitation support. Recommendations and effective guidance for future work are also presented.

Strategic Research On Rebco High-Temperature Superconducting Tapes, Tianping Ying, Dongliang Wang, Pengtao Yang, Lin Zhao, Zhongtang Xu, Ziyi Liu, Chao Yao, Yanwei Ma, Xingjiang Zhou, Jinguang Cheng, Zhong Fang

Bulletin of Chinese Academy of Sciences (Chinese Version)

High-temperature superconducting materials, represented by REBCO (REBa2Cu3O7-δ, where RE denotes rare-earth elements), are of significant strategic importance in fields such as energy, healthcare, and large-scale scientific facilities due to their excellent performance in the liquid nitrogen temperature range. However, they still face severe challenges in long-tape uniformity, production cost, and engineering reliability. Future development must shift toward a “material-processing-application” collaborative innovation model, aiming at enhancing flux pinning, optimizing the interfaces and mechanical properties of the multilayer structure, and integrating scalable and intelligent fabrication technologies to promote the low-cost and stable production of high-performance tapes. This study analyzes the core application …

Validation Of Innovative Method Of Murine Vertebral Compression Testing, Sarah Staller

The Journal of Purdue Undergraduate Research

Murine vertebral compression testing is a common technique to quantify trabecular bone biomechanics. Having a precise method of vertebral compression is important for aiding researchers in making clinically relevant discoveries in musculoskeletal research. While many methods exist in literature, there has yet to be established a universal protocol for this procedure. Many challenges exist in vertebral compression, such as the irregular shape of the vertebral body (trabecular region of interest), uneven endplate surface morphology, and surrounding cortical processes. Therefore, the aim of this study was to develop a new method of vertebral compression that accounts for these factors and to …

Implications Of Noninvasive Blood Pressure Pumps On Mean Arterial Pressure, Sammie Miller

The Journal of Purdue Undergraduate Research

Noninvasive blood pressure pumps are recommended as the primary form of acquiring patient blood pressure to test for blood poisoning. The Philips IntelliVue Patient Monitor MP5, the Philips SureSigns VS4/VS3 Vital Signs Monitor, the Philips EarlyVue VS30 Vital Signs Monitor, the Philips IntelliVue Patent Monitor MP2/X2, the Philips IntelliVue Patent Monitor MMS, and the Philips IntelliVue Patent Monitor MP3/X3 were tested for accuracy. The control condition for hypotension was 95/55 (68) mmHg, normal blood pressure was 120/80 (93) mmHg, and hypertension was 155/85 (108) mmHg. The order of values is arrayed according to diastolic, systolic, and mean arterial pressure. The …

A Smart System For Detecting Anatomic And Histological Symptoms Of Diseased Agricultural Plants, Rustam Baratov, Himola Sunnatillayeva, Alimardon Mamatovich Mustafoqulov

Chemical Technology, Control and Management

This study describes a novel agricultural plant disease detecting smart system, capable of handling measured plant body parameters and images received by high resolution camera at the same time. The proposed plant disease detection method is based on evaluation of the signals received by measured and controlled plant body physical parameters like resistance, temperature and capacitance of the plant stem and image processing. An analogue plant model based on an electrical circuit with distributed parameters was developed. In addition, in the article the block diagram of the smart system for the early detection of plant diseases, the circuit diagram, its …

Sdf-1Α Mediates Primary Tumor Escape In Glioblastoma Through Activation Of Mesenchymal Transitions, Charles T. Froman-Glover

The Cardinal Edge

Glioblastoma (GBM), a highly aggressive primary brain tumor originating in glial cells, poses a significant challenge due to its rapid growth and invasive nature within healthy brain tissue.

Current treatments involve surgical resection, chemotherapy, and radiation. These treatments alone are not enough to cure this disease, and a better understanding of the mechanics of the tumor's micro-environment is imperative to furthering the field of cancer research. This research focuses on understanding the tumor microenvironment's impact, specifically investigating the role of stromal cell-derived factor 1 (SDF-1) mechanics on GBM aggressiveness. SDF-1 is known to facilitate disease progression by facilitating chemotaxis toward …

Effect Of Tibial Malrotation On Anterior And Posterior Cruciate Ligaments In Bicruciate-Retaining Total Knee Arthroplasty, Muhammad Saakeereen Sa’Audi, Abdul Halim Abdullah, Solehuddin Shuib, Muhammad Azim Mat Raffei, Mohd Fairudz Mohd Miswan, Mohd Afzan Mohd Anuar

Makara Journal of Technology

Osteoarthritis (OA) is a musculoskeletal disorder specified as a joint disease that affects mostly human joints worldwide. Total knee arthroplasty (TKA) is performed to restore the affected joint and relieve the symptoms. However, tibial malrotation, which is one of the most common errors in TKA, results in poor function of the implant and pain after the procedure. People with OA often experience limited mobility and cannot accomplish daily tasks. Finite element analysis (FEA) has been widely applied to interpret the biomechanical and kinematic force along the joint and investigate the cruciate ligament’s mechanical behavior. Unfortunately, one of the problems in …

Dynamic Ankle Brace, Amulya Bajracharya

Beyond: Undergraduate Research Journal

The dynamic ankle brace is a 3D printed brace with geometric mesh patterns and two layers of compression sleeves. The goal of the brace is to design a comfortable slim fit ankle brace that is competitive with current ankle support braces on the market. The geometric braces provided similar levels of inversion and eversion as market braces using different sizing. The braces were tested with a custom built testing rig and human participants proving 3d printed braces are flexible yet durable. User feedback indicates users desired stronger stitching of the braces overall.

To Hear Or Not To Hear: How “Best Interest” Determinations Can Help In The Cochlear Implant Debate, Tessa Wright

Minnesota Journal of Law, Science & Technology

No abstract provided.

Predicting Insulin Pump Therapy Settings, Riccardo L. Ferraro, David Grijalva, Alex Trahan

SMU Data Science Review

Millions of people live with diabetes worldwide [7]. To mitigate some of the many symptoms associated with diabetes, an estimated 350,000 people in the United States rely on insulin pumps [17]. For many of these people, how effectively their insulin pump performs is the difference between sleeping through the night and a life threatening emergency treatment at a hospital. Three programmed insulin pump therapy settings governing effective insulin pump function are: Basal Rate (BR), Insulin Sensitivity Factor (ISF), and Carbohydrate Ratio (ICR). For many people using insulin pumps, these therapy settings are often not correct, given their physiological needs. While …

Interactive Software-Based Modeling For Gait Analysis Of Musculoskeletal Structures, Nada Masood Mirza, Adnan Ali, Mohamad Khairi Ishak

Makara Journal of Technology

Software for interactive musculoskeletal modeling applies diverse scientific and technological concepts to stimulate the movement of musculoskeletal figures. Several tools are available for biomechanical analysis in studying motion and capturing the musculoskeletal representation data to facilitate further evaluation for muscle activation. Musculoskeletal software, such as the OpenSim model, animates, and measures in 3D the structural movement of bones, muscles, joints, ligaments, and such structures in the human body. Users apply graphical interfaces to manipulate the movement science for fast and accurate analysis. OpenSim simulation software features a user-friendly interface to allow the proper clinical application in biomechanics and rehabilitation research. …

Pulsatility Is A Predictive Marker Of Improved Cardiac Function In Patients With Liquid Matrix-Treated Left Ventricular Assist Devices, Philemon Mikail, Rinku Skaria, Marvin Slepian, Janny Garcia, Richard Smith, Zain Khalpey

The VAD Journal

Objective: Left ventricular assist devices (LVADs) are utilized as a bridge to transplant or as destination therapy for patients with end-stage heart failure. Although cardiac offloading from these devices rarely leads to complete remodeling and functional recovery, the use of mesenchymal cells to modulate heart failure has been explored in recent years due to its intrinsic regenerative properties. Current methods of evaluating cardiac function have too much variability, difficulty of access, or require too frequent follow up to create universal weaning protocols. We hypothesized that the administration of amniotic allograft liquid matrix (LM) containing amnion-derived mesenchymal stem cells (aMSCs) in …

Development Of A Wearable Device For Monitoring And Predicting Human Health In Emergencies, Mukhriddin Arabboev, Shohruh Begmatov, Khabibullo Nosirov, Jean Chamberlain Chedjou, Kyandoghere Kyamakya

Technical science and innovation

In recent years, natural disasters and various similar emergencies have caused many people to leave this world early. The need for the use of modern technologies in emergencies is growing day by day. Various modern devices, techniques and methods are used in post-disaster search and rescue operations. The issue of finding a survivor is very important in post-disaster operations. The vital signs of humans are very important in determining the survival of humans. Heart Rate (HR), Blood Pressure (BP), Respiration rate (breathing rate), and Body Temperature (BT) values are considered four essential vital signs that must be measured regularly. In …

Creating Reel Designs: Reflecting On Arthrogryposis Multiplex Congenita In The Community, Iris Layadi

Purdue Journal of Service-Learning and International Engagement

Because of its extreme rarity, the genetic disease arthrogryposis multiplex congenita (AMC) and the needs of individuals with the diagnosis are often overlooked. AMC refers to the development of nonprogressive contractures in disparate areas of the body and is characterized by decreased flexibility in joints, muscle atrophy, and developmental delays. Colton Darst, a seven-year-old boy from Indianapolis, Indiana, was born with the disorder, and since then, he has undergone numerous surgical interventions and continues to receive orthopedic therapy to reduce his physical limitations. His parents, Michael and Amber Darst, have hopes for him to regain his limbic motion and are …

Poly(2-Hydroxyethyl Methacrylate) Hydrogels For Contact Lens Applications–A Review, Kushendarsyah Saptaji, Nurlaely Rohmatul Iza, Sinta Widianingrum, Vania Katherine Mulia, Iwan Setiawan

Makara Journal of Science

The emerging technology in biomedical engineering requires biocompatible materials, which are also referred to as biomaterials. For a material to be considered biocompatible, it should not interact with human tissues in a harmful way, and vice versa. Various properties of biocompatible materials, such as mechanical and optical properties, have to be considered for different biomedical applications. One of the most popular applications of biomaterials is for contact lenses. Hydrogels, specifically poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels, are among the most popular ones in ophthalmologic applications, especially in soft contact lenses. This paper reviews the use of PHEMA hydrogels as one of the …

Build Your Own Body Mod: Empowerment Through Prototyping And Design, Anaiss Arreola, Katherine R. Ganim

Journal of Science Education for Students with Disabilities

When you don’t have a hand, what could you have instead? This article introduces the impact of inviting youth with disabilities to learn tools and technology to design their own solutions and advocate for their own future. This approach to programming is rooted in a mindset of designing WITH, not FOR. Not only are design outcomes improved when users are incorporated into the process, but this approach has been shown to improve confidence in creating one’s own solutions. These programs include hands-on “design-your-own-body-mod” workshops, as well as a budding inclusive design consultancy led by youth with disabilities. Through this programming, …

Thermal Properties Of 18f-Fdg Uptake And Imaging In Positron Emission Tomography Scans Of Cancerous Cells, Carleigh R. Eagle

PANDION: The Osprey Journal of Research and Ideas

Positron Emission Tomography (PET) scans can utilize a radioactive tracer, in this case 2-deoxy2-[fluorine-18] fluoro-D-glucose (¹⁸F-FDG), to visualize malignant tumors in cancer patients. The uptake was compared to glucose to understand the difference in thermal properties, which contribute to the ability to image the cancerous cells. The uptake of ¹⁸F-FDG by cancer cells and the imaging process of positron emission tomography were reviewed from a thermodynamic perspective. Gastrointestinal and neurological imaging techniques were reviewed to understand the role of PET imaging in different areas of the human body.

In The Pursuit Of Assistance: A Team's Desire To Not Let A Congenital Amputation Get In A Young Boy's Way, Carl Russell Iii, Gavin Loucks, Kirsten Wozniak

Purdue Journal of Service-Learning and International Engagement

EPICS is a service-learning design program run through Purdue University. It strives to teach students design skills through providing for individuals, communities, and organizations in the surrounding area while mirroring engineering industry standards. BME (Biomedical Engineering) is a team within EPICS that strives to serve community partners through biomedical applications. William Sevick is an elementary school student with a congenital arm amputation. William and his family have been working with the BME team for the past three years designing assistive devices with the purpose of improving his actions in daily life such as eating, playing games, and riding his bike.

An Affordable And Portable Palpable System For Sensing Breast Tissue Abnormalities, Cody J. Clarke

Montview Journal of Research & Scholarship

Due to the high cost of equipment and lack of trained personnel, manual palpation is a preferred alternative breast examination technique over mammography. The process involves a thorough search pattern using trained fingers and applying adequate pressure, with the objective of identifying solid masses from the surrounding breast tissue. However, palpation requires skills that must be obtained through adequate training in order to ensure proper diagnosis. Consequently, palpation performance and reporting techniques have been inconsistent. Automating the palpation technique would optimize the performance of self-breast examination, optimize clinical breast examinations (CBE), and enable the visualization of breast abnormalities as well …

Brain Image Clustering By Wavelet Energy And Cbsso Optimization Algorithm, Hasan Hosseinzadeh, Mohammad Sedaghat

Journal of Mind and Medical Sciences

Previously, the diagnosis of brain abnormality was significantly important in the saving of social and hospital resources. Wavelet energy is known as an effective feature detection which has great efficiency in different utilities. This paper suggests a new method based on wavelet energy to automatically classify magnetic resonance imaging (MRI) brain images into two groups (normal and abnormal), utilizing support vector machine (SVM) classification based on chaotic binary shark smell optimization (CBSSO) to optimize the SVM weights.

The results of the suggested CBSSO-based KSVM are compared favorably to several other methods in terms of better sensitivity and authenticity. The proposed …

An Arm And A Leg: Medtech Perspectives On Human-Centered Design, Evan D. Poff

Marriott Student Review

The art of human-centered design accounts for both technological and emotional specifications in order to deliver meaningful products that meet the specific needs of the individual customer. Every business professional can deepen his or her understanding of human-centered design – regardless of our industry of choice – by looking to perspectives that the business of medical technology offers. To that end, this article draws upon interviews with three figures in this remarkable field, distilling their insights on how to cultivate businesses that produce human-centered solutions.

Engineering Success On The Field: A Reflection On The Epics Ironman Pediatric Prosthetic Project, Glynn Gallaway

Purdue Journal of Service-Learning and International Engagement

Glynn Gallaway is a student in the Purdue Mechanical Engineering Class of 2020 with interests in the health care, assistive technology, and medical device industries. Glynn is from Dallas, Texas, and was inspired to pursue this career path through her interactions with youth with special needs. She joined the EPICS Ironman team in the fall of 2016 during her first year at Purdue as a part of the learning community. In this article, she discusses her experiences on the Ironman team creating a pediatric prosthetic for a young local athlete. The goal of the Ironman team is to create a …

A New Technique To Improve The Operation Of Prosthetic Limbs During Muscle Fatigue, H. Albunashee, G. Rasool, K. Iqbal, G. White

Journal of the Arkansas Academy of Science

Prosthetic limbs hold a promise to renew the quality of life for the amputee. Neural commands are decoded via a classifier to generate control signals for the prosthetic devices. In the literature, many challenges and limitations have been identified that affect the prosthesis operation. One such drawback is muscle fatigue which degrades the surface electromyogram (sEMG) signals, and consequently, the performance of the deployed classification algorithm declines from 90% to 50% of average accuracy. We used a new technique using the Linear Discrimination Analysis (LDA) algorithm and the muscle synergy-based task discrimination (MSD) algorithm to improve the classification accuracy. In …

3d Printing In Healthcare, Caleb Branch

The Review: A Journal of Undergraduate Student Research

Technology is everywhere. Technology surrounds every aspect of 21^st century life. It is in the cell phones we use, the cars we drive, and even the food we eat. A large portion of modern technology used is taken for granted and overlooked. Despite this, some technology fields continue to grow. Biomedical engineering, specifically 3D printing’s applications to healthcare, has been often overlooked until. Regardless of its status in the mainstream, 3D printing is prosperous in healthcare and its future looks bright. This piece analyzes 3D printing in healthcare. It hones in on the finer details of each specific topic, …

Improvements To Uhmwpe, Brooke Mckelvogue

Journal of Undergraduate Research at Minnesota State University, Mankato

Ultra high molecular weight polyethylene (UHMWPE) is a material used in artificial implants for articular joint replacements. However, these implants have a limited lifespan in which the patient will be pain-free due to the wear of the UHMWPE components. Recently crosslinking, or exposing the material to radiation, has been used to extend the wear resistance of UHMWPE. Crosslinking introduces another set of drawbacks; mainly the reduction of the fracture toughness of UHMWPE and the generation of free radicals, which leave the polymer vulnerable to damage from oxidation. Currently, research is being conducted on other methods to increase the wear resistance …

Computational Model Of A Left Ventricle: Showing The Effects Of Inertia On Cardiac Dyssynchrony, Andrew Mcnally, Matthew Korpela, Erin Lamke, Matthew Hudson

Journal of Undergraduate Research at Minnesota State University, Mankato

In an effort to research heart failure, a leading cause of death in the industrialized world, this research team has developed a segmented lumped parameter model of the left ventricle. The computations model developed focuses on dyssynchrony, a heart condition where some regions of the heart vary significantly in properties like internal muscle resistance, mass, or elastance. Inertial effects are often assumed as negligible by cardiovascular models. One primary function of this model is to investigate inertial effects as they relate to mechanical cardiac dyssynchrony. An added dimension of this analysis is to observe the thermodynamics of the cardiac cycle …

Artificial Devices As A Viable Alternative To The Conventional Heart Transplant, Hadassah Radzik

The Science Journal of the Lander College of Arts and Sciences

The human heart is one of the most vital organs in the body. It distributes blood throughout the body, providing the body with oxygen and nutrition, and contributes to metabolism. When the heart fails, blood flow is impaired, thereby limiting the exchange of oxygen within the cardiopulmonary system as well as diminishing oxygenation and nutrition to the other major organs and periphery. The only current proven treatment for advanced heart failure is cardiac transplant. Given the heart’s importance and the scarcity of donated organs, modern medicine has experimented with the creation of an artificial heart. Because the heart is primarily …