Biomedical Devices and Instrumentation Commons^™

Cardiac Twitch Force Measurement System, Tara Hoffman, Sebastian Carrascal Gómez, Julian Macdonald

Biomedical Engineering

The goal of this project is to develop a low-cost and accurate force measurement system and method of measurement to be used in the testing of grown cardiac tissue samples. The primary stakeholder in this project is Dr. Luke Perreault, a biomedical engineering professor at California Polytechnic State University San Luis Obispo who is studying grown cardiac tissue rings, and any of his student lab personnel. Other stakeholders include other researchers in the tissue engineering field who require a similar form of testing to the methods developed in this project.

This document will introduce the identified problem and background as …

Design And Parametric Testing Of A Transimpedance Amplifier For Low-Power Biomedical Applications, Stanlon Tan, William Chung, Brandon Wu

Electrical Engineering

This project developed and evaluated an optical sensing system for detecting changes associated with glucose concentration. The system combined a laser-diode, cuvette sample holder, photodiode, resistive-feedback transimpedance amplifier, high-resolution analog-to-digital converter, and microcontroller. Parametric testing evaluated the effects of input current and feedback resistance on transimpedance gain, output range, and linearity. Firmware was developed to configure the ADC, average repeated conversions, monitor measurement variation, convert raw digital counts into voltage using a source-meter calibration equation, and compare sample measurements with a water reference. A cuvette enclosure maintained alignment between the laser-diode, sample, and photodiode while reducing external optical interference. Testing …

Restoreband: An Electromyography Band For Tracking Forearm Muscle Action And Activation In Post-Stroke Adults, Mairin T. Mullen, Melody Nwagwu, Kosuke Nishimura, Benjamin Miramon

Biomedical Engineering

This study involves the design of a non-invasive surface electromyography (EMG) band to estimate hand posture for individuals recovering from stroke and other neuromuscular disorders. The device is meant to measure forearm muscle activation to provide objective recovery data that can supplement traditional rehabilitation. Current EMG systems are often expensive, cumbersome, and difficult to use. The goal of this study is to develop an affordable, accurate, and easy to use solution that improves access to EMG motor monitoring.

The key stakeholders include stroke survivors, clinicians, and the project sponsor, Dr. Espinoza-Wade. This report includes project introduction, background, objectives, and project …

A Security Framework For Pacemaker Lead Failure: Anomaly Detection System And Failsafe Policy Considerations, Ethan Wagner

Master's Theses

Embedded system security in implantable medical devices (IMDs) remains an underexplored challenge due to the unique constraints of these systems. Specifically, pacemakers are optimized for ultra-low power consumption to maximize device lifespan, are highly resource constrained, and demand reliable and correct operation to prevent severe health consequences. These systems rely on sensing electrodes, called leads, to detect cardiac activity and stimulate the patient’s heart when appropriate. Therefore, pacemaker lead integrity is a critical issue, as malfunction or compromise can result in device failure jeopardizing patient safety.

The security framework presented in this thesis integrates several works to proactively detect and …

Characteristic Stress And Strain Optimization Of Cardiovascular Catheters With Laser-Cut Hypotubes Using Finite Element Analysis, Kyle E. Hirth

Master's Theses

Cardiovascular catheter systems rely on laser-cut hypotubes to balance flexibility and structural integrity required for minimally invasive surgical procedures.  Optimizing these mechanical characteristics remains a significant challenge.  This study aims to investigate the influence of key laser-cut geometric parameters on the mechanical performance of hypotubes through finite element analysis.

Commercially representative laser-cut hypotubes were modeled and a finite element model was developed.   Geometric design parameters were varied across a design space consisting of pitch values ranging from 0.006 in. to 0.018 in. and cuts per revolution (CPR) ranging from 2.5 – 4.5.  For each pitch and CPR combination, loading stiffness …

Transcranial Ac Modulation Of Cerebellar Nuclear Activity In Awake Animals, Nuran Kavakli

Dissertations

Entrainment of cerebellar nuclear (CN) cells via cerebellar transcranial alternating current stimulation (ctACS) has been reported in animals under ketamine/xylazine anesthesia. Our main objective was to demonstrate modulation of CN activity in unanesthetized, freely moving animals using ctACS. Multi-channel carbon-fiber electrodes were implanted into the interpositus nucleus for recording multi-unit (MU) activity, and thin-film electrodes were implanted subcutaneously over the posterior cerebellum for stimulation. A frequency-domain-based metric was developed to quantify modulation from MU signals. The results demonstrated modulation in a wide range of frequencies (4 Hz-300 Hz) as in anesthetized animals. In contrast, the amplitude of the peak in …

Visualization And Marker-Less Tracking Of User-Defined Pre-Processed Mri Articulator Data Using Deep Learning, Michael De George

Student Theses

This thesis presents a comprehensive framework for the automated tracking and visualization of articulatory movements based on magnetic resonance imaging (MRI) data. A well-known data analysis tool for markerless pose estimation, known as DeepLabCut, is investigated for this purpose. The performance of this tool is enhanced through the design and implementation of a pre-processor. DeepLabCut is a markerless pose estimation toolbox based on deep learning, which overcomes the issue of making manual annotations frame-by-frame. Limitations from manually marking the MRI images are addressed by implementing transfer learning with convolutional neural networks to achieve accurate, user-defined articulator tracking without markers. Current …

Hyposense: Multimodal Physiologic And Voc Wearable For Early Hypoglycemia Detection, Nidhi R. Patel

Honors Theses

Hypoglycemia remains a significant safety concern for insulin-dependent individuals, especially when blood glucose declines rapidly during exercise, sleep, or periods of impaired hypoglycemia awareness. Current continuous glucose monitors and automated insulin delivery systems have helped to improve diabetes management, but these technologies primarily respond to glucose trends after they have already started and may not actually provide sufficient warning before symptoms occur. This thesis describes the development of HypoSense, a noninvasive wrist worn wearable concept that is designed to support earlier hypoglycemia risk detection through multimodal physiologic and volatile organic compound emission sensing. HypoSense combines volatile organic compounds/gas sensing with …

A Solution For Safe Pivot Transfers In A Population With Limited Mobility, Elizabeth A. Mitchell, Sean R. Giamportone

Honors Theses

Sit-to-stand pivot transfers are one of the most frequently performed movements for

individuals with limited mobility. This movement is very often performed in long-term care

facilities and clinics. Despite the commonality, this transfer poses a significant risk of injury to

both the patient and caregiver; falls, musculoskeletal injuries, and the reduction of independence

can result from issues associated with these transfers. Existing assistive devices, Hoyer lifts and

sliding boards, present limitations with cost, size, storage, and usability; thus, caregivers rely on

the hands-on manual transfer that increases the risk of injury. The goal of our team was to

address these …

Multiscale Architecture Governs Stability In Suction-Actuated Variable Stiffness Catheters, Sheridan Lee

McKelvey School of Engineering Graduate Student Theses & Dissertations

Endovascular procedures require devices with widely varying mechanical properties: flexibility for navigating tortuous vessels and rigidity for stable therapeutic delivery. Suction-actuated variable stiffness sheaths address this challenge by incorporating axial wire string arrays that mechanically couple under suction to increase flexural rigidity. However, prototype devices achieve stiffening ratios below theoretical predictions, suggesting that interlayer mechanics and string positioning play a critical role. This study investigates whether interweaving polytetrafluoroethylene (PTFE) tape within the string array enhances flexural rigidity modulation and curvature stability. Prototype devices with varying wrap configurations were fabricated and evaluated using flexural testing, curvature stability testing, and mathematical modeling. …

Effects Of A Passive Assistive Hamstring Device On Overground Running Kinematics And Hamstring Activation., Quinn Castner

All Theses

Hamstring strain injuries are among the most common and recurring injuries in sports, occurring most often during the terminal swing phase of gait. Despite progress in rehabilitation, the incidence of injury has only increased, suggesting a need for a novel intervention. We designed a passive, assistive, wearable device with two specific criteria in mind: to offload the hamstrings during running, and do so without hindering normal kinematic patterns. The device consists of an adjustable elastic band anchored proximally at the waist and distally just above the ankle joint center. It stretches and shortens with the hamstrings, providing passive hip extension …

Development Of Low-Cost Triaxial Force Sensor For Measurement Of Human-Exoskeleton Interaction Forces, Hamdan Khan Sarvathullah

All Theses

Contemporary research suggests that shear force is a major contributor to discomfort and pressure injury. However, the variation of shear forces during human-exoskeleton interaction dynamics is a highly unexplored field. The high cost of commercial triaxial force sensors may be a major factor in the notable lack of research in this field. Therefore, in this paper, we present a low-cost, 3D-printed triaxial force sensor designed specifically to measure the triaxial interaction forces between an exoskeleton and its user. The triaxial force sensor uses Carbon-Black/Silicone Rubber (CB/SR) strings to measure shear forces, whereas the normal force is measured with a Force …

Picc-Pal: A Support Band For Independent Picc Line Use, Kylie Luker

Honors Theses

This project presents the design and evaluation of PICC-PAL, a wearable assistive device intended to improve independence and usability for patients managing peripherally inserted central catheters (PICC lines) at home. Current at-home PICC line management often requires help due to the fine motor skills needed to connect and secure tubing. This increases reliance on caregivers and introduces potential risks such as infection and dislodgement. Through stakeholder analysis, prior art evaluation, and iterative prototyping, a device was developed to stabilize the PICC line lumen and enable one-handed connection of medical tubing. Throughout the project, multiple design concepts were explored, with the …

Quantitative Fluorescence Imaging Using A Paired Agent Approach For Improving Surgical Decision Making, Sanjana Pannem

Dartmouth College Ph.D Dissertations

Surgical resection remains to be the cornerstone of treatment for most solid tumors, where the primary objective is to remove all visible and microscopic disease. However, the extent of tumor resection is inherently limited by the surgeon’s ability to distinguish tumor from normal tissue, intraoperatively. As a result, positive surgical margins (PSM), where residual tumor remains after surgery, are a common occurrence and are associated with increased recurrence, need for adjuvant therapies, dismal patient outcomes, and high healthcare costs.

Fluorescence guided surgery (FGS) has emerged as a promising technique to enhance intraoperative visualization of tumors and may help reduce the …

A Treatise On Tool Development: The Arthroscope’S Cultural, Technological, And Metascientific Translation, Montgomery F. Waterer

Honors Theses

The arthroscope was a revolutionary development in the fields of medicine, engineering, and ethics. There are many valuable lessons to be learned from the story of its development and translation that are relevant to the future of medicine and society. Beginning with a brief description of the tool’s design, this paper will examine a period within the history of the arthroscope. This window contains multiple innovators and ends with the life and work of Dr. Robert Jackson. In examining the relevant historical facts of its development, this paper will then briefly address the importance of sports medicine in the development …

Opportunistic Breast Cancer Detection With Photon-Counting Ct: A Quantitative Pilot Study Of Reconstruction-Dependent Image Quality, Graham Hannon

McKelvey School of Engineering Graduate Student Theses & Dissertations

Photon-counting computed tomography (PCCT) has emerged as a promising imaging modality with improved spatial resolution and contrast capabilities compared to conventional energy-integrating detector systems. These advantages present an opportunity for opportunistic detection of breast cancer in routine thoracic CT scans that include breast tissue. In this pilot study, we evaluated the feasibility of opportunistic breast cancer detection using clinical PCCT data through quantitative image analysis. Two patients with confirmed breast malignancies and corresponding thoracic PCCT scans were retrospectively analyzed. Dedicated reconstructions were performed with varying convolution kernels, field-of-view sizes, and virtual monoenergetic spectra. Image quality was assessed using signal-to-noise ratio …

Implantable, Sensor-Embedded Vascular Graft Towards Wireless Monitoring Of Stenosis, Nnamdi Dike

LSU Master's Theses

Arteriovenous (AV) grafts are commonly used to provide vascular access for hemodialysis in patients with end-stage renal disease. Despite their widespread use, AV grafts are prone to complications such as stenosis and thrombosis. Early detection of these conditions remains challenging with current monitoring methods too costly or insufficient. This work presents the design, fabrication, and validation of an LC pressure sensor embedded within a model AV graft to enable real-time monitoring. The proposed system integrates a parallel-plate capacitive pressure sensor with a spiral inductor to form an LC circuit embedded within an elastomeric graft wall. The Ecoflex 00-30 dielectric layer …

Polymer Microstructures For Advanced Biomanufacturing, Tongyao Wu

LSU Doctoral Dissertations

With the continued growth of the biopharmaceutical industry, the demand for scalable, robust, and resource-efficient platforms for large-scale mammalian cell culture is amplified. Recent developments in microfluidic technology, such as precise control of the microenvironment, showed the potential to improve the performance of cell culture systems. However, constrained by scalability and operational efficiency, applying such approaches to large-scale cell culture and biopharmaceutical production presents challenges. This dissertation addresses these challenges through three independent but conceptually related technological developments. First, a roll-to-roll (R2R) fabrication process was developed for the scalable production of hollow microcarriers (HMCs). HMCs provide three-dimensional microenvironments suitable for …

Babycheck, Ayla V. Campbell, Eleanor M. Tweedy

Biomedical Engineering

The BabyCheck project was created to design and test a device that can collect a small blood sample from the fetal scalp during labor. The goal is to reduce uncertainty when fetal heart rate tracings are unclear, especially in Category II cases where it can be difficult for clinicians to decide the safest next step. Current monitoring methods either rely on interpreting heart rate patterns or use more invasive procedures to gather biochemical information. BabyCheck was designed to provide a simpler and more controlled way to collect a small blood sample that could help guide these decisions.

The final prototype …

Jaundease Phototherapy Vest Test Plan, Sujay Panthulu, Jasdev Banwait, Gwynn Moss, Solomon M. Fernandez

Biomedical Engineering

Neonatal hyperbilirubinemia is a common condition affecting more than 60% of newborns, caused by an excess buildup of bilirubin in the blood due to the liver’s limited ability to process it efficiently [1]. The standard treatment involves hospital-based phototherapy, where infants are placed in incubators under blue light to break down bilirubin in the skin. Although effective, this approach requires infants to remain under the lights for 12–18 hours per day, often with eye protection, and separated from their parents—disrupting early bonding and potentially contributing to toxic stress that can impact neurological and emotional development [2]. While at-home phototherapy solutions …

Iud Insertion Pain Management, Sandhya Sridhar, Olivia Armas, Lucy Campochiaro

Biomedical Engineering

This project focuses on developing an atraumatic cervical stabilization device that serves as a modern alternative to the traditional tenaculum used during IUD insertion procedures. Current devices rely on sharp metal prongs that pierce the cervix and often cause significant pain and bleeding. The goal of this project is to design a device that provides the same stability and control for clinicians while eliminating the need to puncture cervical tissue. The device is intended to be used by gynecologists, nurse practitioners, physician assistants, primary care physicians, or any medical professional performing an IUD insertion. The device is intended to be …

Newborn Spinal Needle, Allison Inouye, Kyle Morton, Evan Russell

Biomedical Engineering

Spinal punctures, or lumbar punctures, are important diagnostic procedures used to collect cerebrospinal fluid (CSF) to diagnose issues in the central nervous system (CNS) such as meningitis. While these procedures are routinely performed on adult and neonatal patients, the current tools are not optimized for use on newborns. Existing spinal needles are often modified versions of adult devices, leading to challenges in fluid collection efficiency, user ergonomics, and patient safety when used in neonatal care.

The Newborn Spinal Needle Project aims to design and develop a spinal needle specifically optimized for neonatal anatomy and clinical workflow. The goal is to …

Orthopedic Bone Drill, Logan G. Schmid, Matthew T. Wold, May Geng

Biomedical Engineering

This project aims to design a bone drill for orthopedic procedures which alleviates the heat generated in the bone during drilling.

Methods For Radiation-Sparing Navigation In Endovascular And Spine Surgery, William Ross Warner

Dartmouth College Ph.D Dissertations

Modern surgical navigation systems improve procedural accuracy, limit complications, and can reduce reliance on intraoperative ionizing radiation, yet their adoption remains uneven across surgical domains. Informed by clinical immersion, this thesis identifies and addresses two unmet needs revealed through contrasting image-guidance practices in endovascular and spine surgery, where existing guidance techniques are costly, intermittent, or fundamentally limited. Specifically, these needs include (1) the absence of radiation-sparing navigation techniques for endovascular procedures, which rely heavily on 2D x-ray angiography, and (2) the need for dynamic registration methods in open spine surgery, where navigation accuracy can degrade after initial registration and intraoperative …

Volumetric Wear Analysis Of Polyethylene Orthopedic Liners Using Point Clouds, Gabriel Landi

Dartmouth College Master’s Theses

In vivo wear of ultra-high molecular weight polyethylene (UHMWPE) orthopedic bearings represents a major problem in shoulder and knee arthroplasty, with significant amounts of devices failing due to the complication itself, and even more due to associated reasons for retrieval, including aseptic loosening. However, quantification of UHMWPE wear has largely been limited to linear and in vitro volumetric analyses, obscuring the understanding of the amount of clinically relevant material loss. This study proposes new methods to measure articular, rim, and backside surfaces of retrieved shoulder and knee UHMWPE liners, centered around the coordinate measuring machine (CMM)-based collection of high density …

Stentrx, Emma Barna, Minuthi Cooray, Bruce Newlands, Joseph A. Sabetta

Williams Honors College, Honors Research Projects

This project aims to develop a biodegradable, drug-eluting biliary stent for the treatment of biliary cancers. Current metal stents that restore bile flow bit are non-degradable, prone to migration, and unable to deliver drugs locally. The proposed stent will be biocompatible, biodegradable, and capable of controlled drug release to both maintain bile flow and treat tumors. The end goal is to produce a functional prototype that can be deployed via a minimally invasive catheter and maintain bile duct patency for at least three months. The project is expected to be involved in the NEOMED Bench-to-Bedside competition and provisionally patented.

Rapid Skin Stapler, Emma J. Patterson, Allison M. Milligan, Morgan E. Dunlap

Williams Honors College, Honors Research Projects

Severe burn injuries frequently require split-thickness skin grafts, with metal surgical staples serving as the current standard for fixation. While staples provide rapid and secure placement of graft material, they also introduce significant challenges. Removal is painful, time-consuming, and often requires sedation in pediatric patients, leading to added risk, resource strain, and poor patient experience. These drawbacks highlight the need for improved fixation methods that maintain graft stability while reducing procedural burden. This project applies the engineering design process to address these challenges through identification of user needs, translation into design inputs, risk assessment, and development of a prototype aimed …

Breech Baby, Madison Kaufman, Cassidy Allen, Lilian Mills

Williams Honors College, Honors Research Projects

Our project aims to develop a non-invasive device to assist in turning breech babies to a head down position before delivery. Pregnant women facing breech presentations often need safe and effective solutions, yet current options like external cephalic version (ECV), maternal positioning techniques, and cesarean sections can present challenges. Key barriers include variability in maternal and fetal anatomy, patient comfort, compliance, and training for healthcare providers, along with cost and insurance concerns.

Our innovative device will address these issues by providing clear guidance and support throughout the process. It will prioritize minimizing discomfort and risk, ensuring adaptability for various stages …

Design And Validation Of A Novel Patterned Microfluidic Culture Platform For Hipsc-Cm Maturation, Anisia Gabriela Țiplea

Dartmouth College Master’s Theses

Adult cardiomyocytes (CMs) are among the most challenging cells to culture in vitro, given their poor adherence to plastic culture wells and poor maturation outside the native extracellular matrix (Narkar et al., 2022). Human induced pluripotent stem cell-derived CMs (hiPSC-CMs) offer a viable alternative to study heart development and disease progression. While not comparable to adult CMs in their maturity (Narkar et al., 2022), they mimic the clinical phenotypes of heart failure and are more feasible to culture. Nevertheless, hiPSC-CMs require specialized culture conditions that cannot be achieved with 2D static culturing, which fail to replicate native tissue environments (X. …

A Chicken Model For Non-Invasive Diagnosis Of Infant Developmental Dysplasia Of The Hip (Ddh) Using Acoustic Transmission Measurements, Aliza Shah

Honors Undergraduate Theses

Developmental dysplasia of the hip (DDH) is a condition characterized by abnormal development and stability of the hip joint. In a healthy infant, the femoral head (ball) fits securely within the acetabulum (socket of the pelvis), allowing for proper joint function. In DDH, the relationship is disrupted, ranging from mild acetabular dysplasia to partial (subluxation) or complete dislocation of the femoral head. This condition represents a range of structural abnormalities that develop during early growth. The integrity of the hip joint is essential for physical mobility, and disruption of this structure can lead to significant functional impairment. DDH may result …