Biomedical Devices and Instrumentation Commons^™

Dynamic Ankle Brace, Amulya Bajracharya

Beyond: Undergraduate Research Journal

The dynamic ankle brace is a 3D printed brace with geometric mesh patterns and two layers of compression sleeves. The goal of the brace is to design a comfortable slim fit ankle brace that is competitive with current ankle support braces on the market. The geometric braces provided similar levels of inversion and eversion as market braces using different sizing. The braces were tested with a custom built testing rig and human participants proving 3d printed braces are flexible yet durable. User feedback indicates users desired stronger stitching of the braces overall.

Novel Microfluidic Devices To Model The Interactions Between Lymphatics And Breast Cancer, Jade Weber

McKelvey School of Engineering Theses & Dissertations

The lymphatic system is responsible for immune circulation and fluid balance in the body. It accomplishes this by draining interstitial fluid from local tissue and transferring it to lymph nodes and back into blood circulation. However, this process is implicated in many pathologies, one of the most dangerous being breast cancer metastasis to the lymph nodes. The largest factor in breast cancer patient mortality is metastasis. Lymphangiogenesis, the growth of new lymphatic vessels, has been thought to play a dynamic role in aiding breast cancer metastasis. Breast cancer tumor cells have been shown to remodel the functionality of local lymph …

Cerebral Blood Flow Measured By Diffuse Correlation Spectroscopy For Monitoring Depth Of Anesthesia In Piglets, Mert Deniz Polat, Kurtulus Izzetoglu, Randolph Sinahon, Meltem Izzetoglu, Shadi Malaeb

St. Chris Research Day

No abstract provided.

A General-Purpose Software Platform For Closed-Loop Neuromodulation, William Engelhardt

McKelvey School of Engineering Theses & Dissertations

Implementing closed-loop neuromodulation therapies is a challenging and expensive endeavor. It requires developing software capable of acquiring signals from a bio-signal amplifier, analysis of these signals, and initiation of precisely timed stimulation, all of which need to be accomplished in real-time with very low latency. Developing this software is difficult, as it requires a wide range of expertise ranging from interfacing with hardware to real-time signal processing. Even when successfully implementing such a system for one set of hardware, it often then only works within the laboratory that conceived it. This is because of the inherent heterogeneity in the devices …

The Antler: The Design And Development Of An Independent Shower Support Stand For Those Living With Lower Extremity Limb Loss, Kylie Wright

Honors Theses

While we do not often think about it, taking a shower is a privilege. Standing in the hot water, cleaning off after a long day outdoors, and taking a moment to simply relax is an experience that most people in the U.S. have participated in. However, about 1.4 million Americans do not have this luxury3. Lower extremity amputees have long been advised to shower while seated for their safety. This population is unable to experience the simple independence that accompanies standing in the shower. Despite the growing rate of amputations each year, no products are currently available on the market …

To Hear Or Not To Hear: How “Best Interest” Determinations Can Help In The Cochlear Implant Debate, Tessa Wright

Minnesota Journal of Law, Science & Technology

No abstract provided.

Wireless, Handheld Diffuse Reflectance Spectroscopy To Quantify Tissue Microvascular Hemodynamics, Linh Luong, Alex Moazzen, Mark Romine, Katie Cho, Paul Lee

Symposium of Student Scholars

Diffuse Reflectance Spectroscopy (DRS) is a non-invasive optical method to characterize tissue optical properties for disease diagnosis and health monitoring. Two optical fibers are often used in a DRS system: one to deliver light to the tissue and the other to gather diffuse reflectance spectra, which provide quantitative details about the structure and composition of the tissue. The conventional DRS system, however, is expensive, bulky, and composed of fragile optical fibers and multiple electrical connections. Here we propose to build a wireless, handheld, and fiber-less diffuse optical spectroscopy system. Unfortunately, the diffusion approximation utilized for data analysis of the conventional …

Optical Fiber Tip Micro Anemometer [U.S. Patent Us11635315b2], Hengky Chandrahalim, Jeremiah C. Williams

Faculty Publications

A passive microscopic flow sensor includes a three-dimensional microscopic optical structure formed on a cleaved tip of an optical fiber. The three-dimensional microscopic optical structure includes a post attached off-center to and extending longitudinally from the cleaved tip of the optical fiber. A rotor of the three-dimensional microscopic optical structure is received for rotation on the post. The rotor has more than one blade. Each blade has a reflective undersurface that reflects a light signal back through the optical fiber when center aligned with the optical fiber, the blades of the rotor shaped to rotate at a rate related to …

3d Reconstruction Of Syndactylized Hand In Autodesk Recap Photo With Arduino, Caleb E. Scheideger

ONU Student Research Colloquium

Syndactyly is one of the most common congenital malformations of the hand and is a result of a failed separation of adjacent digits. These digits are common among congenital limb malformations that affect 1 out of 2,000-3,000 people at birth. A reconstructive surgery would be needed to separate the digital skin, reconstruct the web space between fingers, and cover the separated digits with soft tissues. Finding the optimal shape and size for a dorsal flap in the web commissure reconstruction is important to avoid web creep. Conducting a numerical study with known mechanical properties, such as Young’s Modulus of the …

Evaluation Of A Portable Gynecological Examination Table On Increasing Access To Cervical Cancer Screenings, Brennan Burrows, Giuliana Motta, Vibhasri Davuluri, Urvee Deo, Aman Tahir, Brindha Rajakumar, Jacob Blumenstein, Eliza Steinberg, Mariam Tobia, Asmita Tuladhar, Abigail Ahn

Medical Student Research Symposium

Introduction: Cervical cancer is a preventable disease affecting millions of women worldwide, with higher prevalence and mortality in developing countries. One explanation of this disparity is due to reduced access to screenings, especially in rural communities where mobile health clinics are limited by what medical equipment they can bring. To address these barriers, an engineering team called Project MESA (Making Examinations Safe and Accessible) designed a gynecological examination table that is portable, lightweight, and easily sanitizable.

Objective: This study aims to (1) evaluate whether the implementation of this device improves the clinician’s ability to perform pap smears as opposed to …

Gesture-Based American Sign Language (Asl) Translation System, Kayleigh Moore, Stefano Pecile, Mahdi Yazdanpour

Posters-at-the-Capitol

According to the World Health Organization (WHO), over 5% of the world's population experiences severe hearing loss. Approximately 9 million people in the U.S. are either functionally deaf or have mild-to-severe hearing loss. In this research, we designed and implemented a translation interface which turns American Sign Language (ASL) gestures captured from a pair of soft robotic gloves into text and speech instantaneously.

We used a combination of flex sensors, tactile sensors, and accelerometers to recognize hand gestures and to record hand and fingers positions, movements, and orientations. The digitized captured gestures were then sent to our proposed translation interface …

Studying And Troubleshooting Lubricity Test On Pressure Wire X Proximal And Distal Coatings, Usama A. Khan

All Graduate Theses, Dissertations, and Other Capstone Projects

Coatings of guidewires used in medical device manufacturing industry are one of the most important element aspects. It defines its efficiency to penetrate through tightest of canals and curves. Guidewires are put through controlled environment to accelerate its age and tested for its mechanical features. Pressure Wire X failed the lubricity testing after being tested by multiple operators and at alternate sites. A cause-and-effect diagram shows all potential causes of test failure. The human factor involved in the test failure was investigated through multiple Gage R&R and training records. Calibration error with the lubricity tester DL1000 was identified and solved …

Enhancing Dental Aligners With Direct 3d Printing Manufacturing, Erin Clark, Lauren Ickes, Tyler Madison

Williams Honors College, Honors Research Projects

Replacement of thermoforming with direct 3d printed aligners, molding appliances for dental and alveolar movement. Currently the process involved requires 3d printing models and plastic thermoforming, trimming and polishing to fabricate the end product. If possible a product that could be 3d printed that had stress retention, crack resistance, and stain resistance properties delivered in thickness between .030 and .040 inches.

Side Cutting Biopsy Needle For Endoscopes, Cade Smarr, Ella B. Brinkman, Christine Skakun, Vincent Grosso

Williams Honors College, Honors Research Projects

Develop a side cutting biopsy needle that fits through the working channel of the endoscope similar to stereotactic needle with syringe suction to overcome the small biopsy samples due to instrument size limitations. The problem users are facing is that the biopsy samples through the endoscope are small secondary to instrument size limitations. The idea for this problem is to develop a side cutting biopsy needle that fits through the working channel of the endoscope similar to stereotactic needle, syringe suction.

Mouthpiece For Patients With Neuromuscular Disorders, Rebekah Starkey, Carissa Thompson, Michael Dickens, Andrew Pero

Williams Honors College, Honors Research Projects

Neuromuscular Disorders (NMDs) impact people throughout the world. An early hallmark of these disorders includes some degree of facial muscle weakness. Respiratory testing is important to evaluate the progression of these patients’ NMDs. However, these tests require that the patient purses their lips around a mouthpiece to create a tight seal. This is a difficult task for one with facial muscle degeneration. This often leads to results that fail to reflect the patient’s true respiratory ability and prevents their physician from providing the appropriate degree of care. The objective of this project was to develop a face mask or mouthpiece …

Neonatal Intraocular Injection And Delivery System, Nina Treacher, Cory Ramsey, Marie Kosco, Jackson Carrell

Williams Honors College, Honors Research Projects

The proposed project is a way to deliver liquid medicine into the neonatal eye to prevent retinal detachment with lower risk for bacterial infection and drug misplacement. Currently, ophthalmologists use diabetic needles to introduce medication to the neonate eye. They estimate the injection location with hand-held calipers. This may allow the medicine to be misplaced from poor needle placement and introduce preventable error. The goal is to improve the delivery system ophthalmologists currently use by investigating ways to alter or enhance commonly used injection systems to make the procedure safer and more effective.

Small-Separation Speckle Contrast Optical Spectroscopy For Intraoperative Assessment Of Parathyroid Glands Viability During Thyroid Surgery, Connor Berger

Symposium of Student Scholars

The parathyroid glands (PTGs) are often damaged during thyroid surgeries due to a lack of methods identifying PTGs and assessing their viability. Damage to PTGs can cause hypocalcemia, a deficiency of calcium in the body. This complication can lead to detrimental consequences with economic burden. The surgeon’s current method of viability assessment is qualitative and subjective. Our technical solution is to employ an optical technique called speckle contrast optical spectroscopy (SCOS) that noninvasively quantifies the blood flow index (Db) of biological tissues at deep tissue levels (>1cm). The goal of this project is to verify SCOS at small source-detector-separation …

An Integrated Electronic-Skin Patch For Real-Time And Continuous Monitoring Of A Panel Of Biomarkers Combined With Drug Delivery, Tanzila Noushin

Electrical Engineering Theses

Inflammatory biomarkers present in the human body play a vital role in medical field by guiding the clinician in decision-making for many diseases. The levels of these inflammatory biomarkers are associated with the severity and progress of several diseases. Researchers have found that increasing severity of many diseases such as cardiovascular disease, after surgery infection, and adverse clinical outcomes due to infectious diseases, results in the elevation of the level of inflammatory biomarkers in human sweat. Furthermore, the inflammatory cytokines indicate the pathophysiology and prognosis of critically ill SARS‑CoV‑2 patients. In this thesis work, different sensors have been developed for …

Engineer And Test A Biodegradable Microneedle Patch To Deliver Meloxicam For Managing Pain In Cattle, Katherine Alejandra Miranda Munoz

Graduate Theses and Dissertations

Microneedle patches are a promising source for transdermal diffusion of macromolecules and are designed to painlessly penetrate the skin. In this study, a biodegradable chitosan microneedle patch to deliver meloxicam for managing pain in cattle was tested. The potential of reuse of the polymeric solution to fabricate the patches, optimization of fabrication, morphological analysis of the microneedle patch and analysis of preservation of the chemical composition after sterilization were evaluated. In-vitro analysis consisted of studying in-vitro penetration mechanical properties, compression testing analysis of microneedle patch, and in-vitro drug release analysis. In-vivo studies were performed to analyze the dissolution capability of …

Evaluation Of Cellulose Nanocrystal Inks And Their Structural Characteristics For 3d Bioprinting Of Customized Scaffolds, Patrick William Kuczwara

Graduate Theses and Dissertations

3D bioprinting of biological scaffolds requires control of the physicochemical properties of each unique structures. A promising material for control of properties is hydrogels, which can help create biomimetic scaffolds with controlled spatial arrangement of materials by integrating biological materials directly into layers during the bioprinting process. Nanocellulose offers a unique combination of properties including mechanical, biomimetic, and biocompatibility. These properties offer flexibility over the types, shapes, and applications of their printed hydrogel scaffolds, (i.e., tissue, drug, encapsulation). However, 3D bioprinting of nanocellulose-based hydrogels requires high loading percentages (i.e., >10 wt%) or chemical crosslinkers (i.e., bis(acyl)phosphane oxides (BAPO)). High solid …