Open Access. Powered by Scholars. Published by Universities.®

Otorhinolaryngologic Diseases Commons

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 1 - 30 of 37

Full-Text Articles in Otorhinolaryngologic Diseases

Prevention Of Oral Mucositis In Cancer Patients, Patricia E. Biel Apr 2019

Prevention Of Oral Mucositis In Cancer Patients, Patricia E. Biel

Evidence-Based Practice Project Reports

Oral mucositis [OM] is one of the most severe non-hematological problems related to cancer treatments and can impact quality of life. It is linked to poorer outcomes due to the associated weight loss, pain, dehydration, and risk of developing life-threatening infections. The purpose of this evidence-based practice project was to determine if OM is preventable with the use of an oral care protocol and zinc supplementation when compared to use of oral care protocols alone. The Johns Hopkins Nursing Evidence-Based Practice Model was used to guide project implementation in an outpatient oncology office. Recommendations were developed from an exhaustive review ...


L-Serine Reduces Reactive Oxygen Species Yield In Cisplatin Treated Zebrafish Utricles, Satya A. Moolani, Elvin Irihamye, Jerry D. Monroe, Michael E. Smith Nov 2018

L-Serine Reduces Reactive Oxygen Species Yield In Cisplatin Treated Zebrafish Utricles, Satya A. Moolani, Elvin Irihamye, Jerry D. Monroe, Michael E. Smith

Posters-at-the-Capitol

Cisplatin is a chemotherapy compound effective against a variety of cancers. However, it can act as an ototoxin and cause hearing loss by promoting reactive oxygen species (ROS) production in auditory tissues. The antioxidant amino acid, L-serine has been hypothesized to lower levels of cisplatin-mediated ROS. In this project, we investigated whether L-serine can reduce cisplatin-mediated ROS production in auditory tissue and potentially act as an otoprotectant during cisplatin chemotherapy. We used a zebrafish utricular tissue culture system and fluorescent ROS indicator dye to spectrophotometrically measure if L-serine could decrease reactive oxygen species levels in cisplatin-treated tissues. We found that ...


Deaf And Hard-Of-Hearing Learners In Emergency Medicine, Lisa M. Meeks, Alina Engelman, Alicia Booth, Michael Argenyi Nov 2018

Deaf And Hard-Of-Hearing Learners In Emergency Medicine, Lisa M. Meeks, Alina Engelman, Alicia Booth, Michael Argenyi

Open Access Articles

Approximately 23% of Americans over age 12 have some level of hearing loss.1 Emergency departments can reduce healthcare barriers for deaf and hard-of-hearing (DHoH) patients through improved patient-physician communication. DHoH students, once they become physicians, may provide one mechanism for reducing existing healthcare disparities and communication barriers for DHoH patients, and may be more adept with patients facing other communication barriers. A renewed interest in disability access and a commitment to social justice has increased efforts toward the inclusion of individuals with disabilities in medical education and training. Despite this increased interest and a growing number of DHoH students ...


Identification Of Oral Clefts As A Risk Factor For Hearing Loss During Newborn Hearing Screening, Patricia L. Purcell, Kathleen Cy Sie, Todd C. Edwards, Debra Lochner Doyle, Karin Neidt Jun 2018

Identification Of Oral Clefts As A Risk Factor For Hearing Loss During Newborn Hearing Screening, Patricia L. Purcell, Kathleen Cy Sie, Todd C. Edwards, Debra Lochner Doyle, Karin Neidt

Journal of Early Hearing Detection and Intervention

Objective: This study assessed whether children with oral clefts are appropriately classified as at-risk for hearing loss at the time of newborn hearing screening and describes their screening and diagnostic results.

Design: Birth certificates were used to identify children with cleft lip and palate or isolated cleft palate born in Washington State from 2008–2013. These were cross-referenced with the state’s Early Hearing Detection, Diagnosis and Intervention (EHDDI) database. Multivariate logistic regression was used to examine associations.

Results: Birth records identified 235 children with cleft lip and palate and 116 with isolated cleft palate. Six children were listed as ...


Bone Conduction Transmission And Head‐Shadow Effects For Unilateral Hearing Losses Fit With Transcranial Cic Hearing Aids, Marc A. Fagelson, Colleen Noe, Jennifer Blevins, Owen Murnane Apr 2018

Bone Conduction Transmission And Head‐Shadow Effects For Unilateral Hearing Losses Fit With Transcranial Cic Hearing Aids, Marc A. Fagelson, Colleen Noe, Jennifer Blevins, Owen Murnane

Owen D. Murnane

Bone conduction transmission and head‐shadow effects were determined with transcranial completely‐in‐the‐canal (TCCIC) CROS hearing aids. Five subjects with documented profound unilateral hearing loss and experience with traditional CROS/BICROS fittings (TCROS) were tested with a CIC hearing aid placed in their poorer ear. Peak SPL was measured at the tympanic membrane and ranged from 105–115 dB SPL at 2000 Hz. Pure‐tone crossover thresholds and functional gain tested at frequencies from 250–8000 Hz varied considerably more than the SPL measures. The pure‐tone results indicated that sensitivity in the better ear was moderately associated ...


Gap Discrimination And Speech Perception In Noise, Marc A. Fagelson Apr 2018

Gap Discrimination And Speech Perception In Noise, Marc A. Fagelson

Marc A. Fagelson

The relation between discrimination of silent gaps and speech‐in‐noise perception was measured in 20 normal‐hearing listeners using speech‐shaped noise as both the gap markers and the noise source for speech testing. In the gap discrimination experiment, subjects compared silent gaps marked by 60 dB SPL 250‐ms noise bursts to standards of either 5, 10, 20, 50, 100, or 200 ms. The gap results were most similar to those reported by Abel [S. M. Abel, J. Acoust. Soc. Am. 52, 519–524 (1972)] as ΔT/T decreased non‐monotonically with increased gap length. In a second ...


Multivariate Analysis To Identify Potential Biomarkers For Prognosis And Treatment Resistance In Head And Neck Cancer Patients, Christina Ann Wicker Jan 2018

Multivariate Analysis To Identify Potential Biomarkers For Prognosis And Treatment Resistance In Head And Neck Cancer Patients, Christina Ann Wicker

Theses and Dissertations--Toxicology and Cancer Biology

It is estimated that nearly 50,000 individuals in the United States will be diagnosed with head and neck cancer in 2017 (American Cancer Society www.cancer.org). Ninety percent of oral cancers are head and neck squamous cell carcinoma (HNSCC). Major obstacles in the treatment of HNSCC are recurrence and treatment resistance, which contributes to increased mortality. Therefore, there is increased need to determine genetic alterations in HNSCC that may be ideal novel drug targets, and biomarkers to improve diagnostic and prognostic testing.

Abnormal localization and overexpression of base excision repair protein and transcriptional regulator Apurinic/Apyrimidic endonuclease (APE1 ...


Mantle Cell Lymphoma In The Thyroid: A Rare Presentation, Uzma Mohammad Siddiqui, Sarika N. Rao, Pallavi K. Galera, Nahida Islam, Mira S. Torres Dec 2017

Mantle Cell Lymphoma In The Thyroid: A Rare Presentation, Uzma Mohammad Siddiqui, Sarika N. Rao, Pallavi K. Galera, Nahida Islam, Mira S. Torres

Open Access Articles

Background: While 2% of all extranodal Non-Hodgkin Lymphomas present in the thyroid, there exists insufficient data to describe the incidence of mantle cell lymphoma in the thyroid. A case series of 1400 patients revealed that < 1% of thyroid lymphomas may be MCL; hence better understanding of the disease course is essential.

Patient Findings: A 65-year-old female was referred for a multinodular goiter. Multiple fine needle aspirations from the dominant right nodule were consistent with Hashimoto's thyroiditis and flow cytometry was negative. Due to progressing dysphagia, she underwent total thyroidectomy.

Summary: Pathology revealed MCL with mantle zone growth pattern in the right thyroid. Flow cytometry showed monoclonal B cells comprising 9% of total cells. The Ki-67 ...


Methicillin-Resistant Staphylococcus Aureus In Acute Otitis Externa, Maria J. Duarte, Elliott D. Kozin, Paulo J. M. Bispo, Andreas H. Mitchell, Michael S. Gilmore, Aaron K. Remenschneider Nov 2017

Methicillin-Resistant Staphylococcus Aureus In Acute Otitis Externa, Maria J. Duarte, Elliott D. Kozin, Paulo J. M. Bispo, Andreas H. Mitchell, Michael S. Gilmore, Aaron K. Remenschneider

Open Access Articles

Objective: Otologic methicillin-resistant Staphylococcus aureus (MRSA) infection has historically been rare, but given the rise in community-acquired MRSA carriage and infection at other body sites, prevalence rates may be changing. The goal of this study was to determine the prevalence of MRSA in recent otologic cultures from patients with acute otitis externa (AOE).

Study design: Retrospective review of an institutional microbiologic database.

Methods: A retrospective analysis was performed on serial culture isolates taken from the ear at a quaternary care hospital from January 2014 to April 2016. The causative pathogen and antibiotic sensitivity was determined by culture isolation and end ...


Temporal Bone Hyperpneumatization And Tinnitus: Clinico-Radiological Evaluation Using Ct Scan, Sattar Razzaq Al-Esawi, Ali Burair Hasan, Deepak Takhtani, Sarwat Hussain Sep 2017

Temporal Bone Hyperpneumatization And Tinnitus: Clinico-Radiological Evaluation Using Ct Scan, Sattar Razzaq Al-Esawi, Ali Burair Hasan, Deepak Takhtani, Sarwat Hussain

Journal of Global Radiology

Purpose: We propose that there is increased incidence of subjective tinnitus (ST) in patients with temporal bone hyperpneumatization (TBHP). The secondary goal of this project is to assess the degrees of association of TBHP with paranasal sinus hyperpneumatization (PNSHP), chronic sinusitis (CS), otomastoiditis (OM) and concha bullosa (CB).

Methods and Materials: A total of 196 patients, who had computed tomography (CT) of the head for various clinical indications, were included in this study. CT head scans of patients with TBHP (n=96) were correlated with control patients (n=100). These patients had no apparent TBHP, history of ST, PNSHP, CS ...


Chemogenetic Stimulation Of The Hypoglossal Neurons Improves Upper Airway Patency, Thomas Curado, Kenneth Fishbein, Huy Pho, Michael Brennick, Olga Dergacheva, David Mendelowitz, +Several Additional Authors Mar 2017

Chemogenetic Stimulation Of The Hypoglossal Neurons Improves Upper Airway Patency, Thomas Curado, Kenneth Fishbein, Huy Pho, Michael Brennick, Olga Dergacheva, David Mendelowitz, +Several Additional Authors

Pharmacology and Physiology Faculty Publications

Obstructive sleep apnea (OSA) is characterized by recurrent upper airway obstruction during sleep. OSA leads to high cardiovascular morbidity and mortality. The pathogenesis of OSA has been linked to a defect in neuromuscular control of the pharynx. There is no effective pharmacotherapy for OSA. The objective of this study was to determine whether upper airway patency can be improved using chemogenetic approach by deploying designer receptors exclusively activated by designer drug (DREADD) in the hypoglossal motorneurons. DREADD (rAAV5-hSyn-hM3(Gq)-mCherry) and control virus (rAAV5-hSyn-EGFP) were stereotactically administered to the hypoglossal nucleus of C57BL/6J mice. In 6–8 weeks genioglossus ...


Empty Nose Syndrome—What Do We Know?, Ethan Frank, Christopher Church Md Jan 2017

Empty Nose Syndrome—What Do We Know?, Ethan Frank, Christopher Church Md

Loma Linda University Student Journal

Empty nose syndrome is a complication of nasal surgery wherein patients develop a persistent, debilitating sense of nasal obstruction and dyspnea despite clear nasal cavities. It is characterized by a discrepancy between prominent subjective symptoms and near total lack of objective findings, making it difficult to diagnose. The pathophysiology of empty nose syndrome is a complex mix of aerodynamic, physiologic, and neurological changes leading to altered airflow and diminished sensory function. Evolving treatment options consist of medical symptom control or surgical reconstruction.


The Use Of Hyperbaric Oxygen Therapy In Idiopathic Sensorineural Hearing Loss: A Case Study, Chad B. Crigger, Md, Stephen L. Wilson, Md Jul 2016

The Use Of Hyperbaric Oxygen Therapy In Idiopathic Sensorineural Hearing Loss: A Case Study, Chad B. Crigger, Md, Stephen L. Wilson, Md

Marshall Journal of Medicine

Idiopathic sudden sensorineural hearing loss (ISSHL) is an otologic emergency that can provoke anxiety in the patient and can be clinically challenging for the practitioner. The natural history of the condition can be as varied as its possible etiologies. Adding to the clinical challenge is the current debate of treatment modalities available. In what follows, we provide a case detailing our treatment course, including the novel use of hyperbaric oxygen therapy (HBOT) as an emerging therapy for sensorineural hearing loss. Additionally, we provide a brief review of the current state of treatment options available in the armament for ISSHL. As ...


Mumps Myocarditis: A Forgotten Disease?, Sheraz Hussain, Mohammad Faizan Zahid, Arshalooz J. Rahman, Mehnaz A. Atiq, S. H. Ibrahim Jan 2016

Mumps Myocarditis: A Forgotten Disease?, Sheraz Hussain, Mohammad Faizan Zahid, Arshalooz J. Rahman, Mehnaz A. Atiq, S. H. Ibrahim

Department of Paediatrics and Child Health

Mumps is an acute viral illness that follows a self-limiting course but up to 10% of cases have a complicated course with the involvement of other organ systems. Myocarditis is reported as a complication but the incidence has greatly fallen ever since the development of the mumps vaccine. A child presented to our department with parotid swelling and fever. Persistent tachycardia with irregular pulse led to further cardiac work up which showed decreased ejection fraction and raised serum cardiac enzymes, indicating myocardial damage. With ionotropic agents and supportive care, there was complete normalization of ejection fraction and serum cardiac enzyme ...


Working Therapeutically With Deaf People Recovering From Trauma And Addiction, Melissa Anderson, Neil Glickman, Lisa Mistler, Marco Gonzalez Oct 2015

Working Therapeutically With Deaf People Recovering From Trauma And Addiction, Melissa Anderson, Neil Glickman, Lisa Mistler, Marco Gonzalez

Melissa L. Anderson

OBJECTIVE: This article reviews what is known about behavioral health treatment of deaf persons with comorbid trauma and addiction.

METHOD: We discuss how to work therapeutically with deaf people with comorbid trauma and addiction, both through a review of the literature and through clinical observations of the authors. The article also includes the personal stories of two people-a Deaf peer specialist and a hearing psychiatrist-who share their humbling stories about the recovery process for deaf people and the challenges of learning to become an effective Deaf mental health care provider.

FINDINGS: Deaf people report higher rates of mental health problems ...


Evolution And Otitis Media: A Review, And A Model To Explain High Prevalence In Indigenous Populations, Mahmood F. Bhutta Jun 2015

Evolution And Otitis Media: A Review, And A Model To Explain High Prevalence In Indigenous Populations, Mahmood F. Bhutta

Human Biology Open Access Pre-Prints

Inflammation of the middle ear (otitis media) comprises a group of disorders that are highly prevalent in childhood, and indeed are amongst the most common disorders of childhood. Otitis media is also heritable, and has effects on fecundity. This means that otitis media is subject to evolution, yet the evolutionary selection forces that may determine susceptibility to otitis media have never been adequately explored.

Here I undertake a critical analysis of evolutionary forces that may determine susceptibility to middle ear inflammation. These forces include those determining function of the middle ear, those affecting host immunity, and those affecting colonization by ...


American Red Cross Sac Advisory On Obstructed Airway-Adults, Richard N. Bradley, Stamatios Lerakis Jan 2015

American Red Cross Sac Advisory On Obstructed Airway-Adults, Richard N. Bradley, Stamatios Lerakis

Richard N Bradley

INTRODUCTION: There were 4,700 deaths due to choking in the United States in 2012. This study was a structured literature review with the objective of determining whether in adults, either conscious or unconscious, with acute foreign body airway obstructions, if any specific resuscitation technique, compared to other techniques, leads to different outcomes.

METHODS: We developed an a priori search definition, and searched PubMed, Google, and OneSearch@IU. We sought additional articles by reviewing the reference lists of articles that we included. We included articles if they addressed original research of treatment of foreign body airway obstruction in adults. We ...


American Red Cross Scientific Review On Obstructed Airway-Adults, Richard N. Bradley, Stamatios Lerakis Jan 2015

American Red Cross Scientific Review On Obstructed Airway-Adults, Richard N. Bradley, Stamatios Lerakis

Richard N Bradley

INTRODUCTION: There were 4,700 deaths due to choking in the United States in 2012. This study was a structured literature review with the objective of determining whether in adults, either conscious or unconscious, with acute foreign body airway obstructions, if any specific resuscitation technique, compared to other techniques, leads to different outcomes.

METHODS: We developed an a priori search definition, and searched PubMed, Google, and OneSearch@IU. We sought additional articles by reviewing the reference lists of articles that we included. We included articles if they addressed original research of treatment of foreign body airway obstruction in adults. We ...


In Adult Patients With Pc-Bppv, Is The Semont Maneuver Effective In Reducing Symptoms Of Vertigo?, Gabriel D. Frampton Jan 2015

In Adult Patients With Pc-Bppv, Is The Semont Maneuver Effective In Reducing Symptoms Of Vertigo?, Gabriel D. Frampton

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not in adult patients with PC-BPPV, is the Semont Maneuver effective in reducing symptoms of vertigo?

STUDY DESIGN: Review of three published, randomized controlled trials (two double-blind and one single blinded), all English language.

DATA SOURCES: The three randomized controlled trials that were used for this review were found using PubMed and Medline. Articles were selected based on relevance and that the outcomes were patient oriented.

OUTCOME(S) MEASURED: Dix-Hallpike Test performed before and after the Semont Maneuver to asses nystagmus and questionnaires/self reported symptom status ...


Olfactory Dysfunction Predicts 5-Year Mortality In Older Adults, Jayant M. Pinto, Kristen E. Wroblewski, David W. Kern, L Phillip Schumm, Martha K. Mcclintock Oct 2014

Olfactory Dysfunction Predicts 5-Year Mortality In Older Adults, Jayant M. Pinto, Kristen E. Wroblewski, David W. Kern, L Phillip Schumm, Martha K. Mcclintock

Psychology & Gerontology Faculty Publications

Prediction of mortality has focused on disease and frailty, although antecedent biomarkers may herald broad physiological decline. Olfaction, an ancestral chemical system, is a strong candidate biomarker because it is linked to diverse physiological processes. We sought to determine if olfactory dysfunction is a harbinger of 5-year mortality in the National Social Life, Health and Aging Project [NSHAP], a nationally representative sample of older U.S. adults. 3,005 community-dwelling adults aged 57–85 were studied in 2005–6 (Wave 1) and their mortality determined in 2010–11 (Wave 2). Olfactory dysfunction, determined objectively at Wave 1, was used to ...


A Pilot Study To Investigate Concerns In Patients Undergoing Neck Dissection Surgery, Daniel Sundar Raj Arulananda Doss Dec 2013

A Pilot Study To Investigate Concerns In Patients Undergoing Neck Dissection Surgery, Daniel Sundar Raj Arulananda Doss

Electronic Thesis and Dissertation Repository

Abstract:

This study investigates concerns in patients undergoing neck dissection surgery. Forty patients were recruited at Pre-surgery, Discharge and 1-month Post-surgery. The Patient Concerns Inventory - Level of Importance questionnaire (PCI-LOI), Shoulder Pain and Disability Index (SPADI), Neck Dissection Impairment Index (NDII) and the University of Washington - Quality of Life questionnaire (UWQOL) were used.

The study identified "Anxiety" at Pre-surgery and "Appearance" at Discharge and 1-month Post-surgery as the important patient concerns. Patients’ concerns were found to change over time. Support for cross-sectional convergent validity of the PCI-LOI was evidenced by significant correlations between the PCI-LOI and the UWQOL (r = -0 ...


Dimethyl Sulfoxide (Dmso) Exacerbates Cisplatin-Induced Sensory Hair Cell Death In Zebrafish (Danio Rerio), Phillip M. Uribe, Melissa A. Mueller, Julia S. Gleichman, Matthew D. Kramer, Qi Wang, Martha Sibrian-Vazquez, Robert M. Strongin, Peter S. Steyger, Douglas A. Contanche, Jonathan I. Matsui Feb 2013

Dimethyl Sulfoxide (Dmso) Exacerbates Cisplatin-Induced Sensory Hair Cell Death In Zebrafish (Danio Rerio), Phillip M. Uribe, Melissa A. Mueller, Julia S. Gleichman, Matthew D. Kramer, Qi Wang, Martha Sibrian-Vazquez, Robert M. Strongin, Peter S. Steyger, Douglas A. Contanche, Jonathan I. Matsui

Cell and Developmental Biology Publications

Inner ear sensory hair cells die following exposure to aminoglycoside antibiotics or chemotherapeutics like cisplatin, leading to permanent auditory and/or balance deficits in humans. Zebrafish (Danio rerio) are used to study drug-induced sensory hair cell death since their hair cells are similar in structure and function to those found in humans. We developed a cisplatin dose-response curve using a transgenic line of zebrafish that expresses membrane-targeted green fluorescent protein under the control of the Brn3c promoter/enhancer. Recently, several small molecule screens have been conducted using zebrafish to identify potential pharmacological agents that could be used to protect sensory ...


Is The Use Of Intestinal Helminths Safe And Effective In The Treatment Of Allergic Rhinitis?, Tanner Mccalley Jan 2013

Is The Use Of Intestinal Helminths Safe And Effective In The Treatment Of Allergic Rhinitis?, Tanner Mccalley

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this EBM review is to determine whether the use of intestinal helminths is safe and effective in the treatment of allergic rhinitis.

STUDY DESIGN: Review of three English language, blinded randomized controlled trials from 2009, 2010, and 2010.

DATA SOURCE: Randomized, controlled, blinded trials comparing the use of intestinal helminths versus visually matched placebo as a treatment for allergic rhinitis found using PubMed and Ovid databases.

OUTCOMES MEASURED: Several different systems were used to evaluate the symptoms or occurrence of AR. Bager et al.2010 uses symptom scores of AR scale of 0 to 3. Feary ...


Review Of Ear Health And Hearing Among Indigenous Australians, Jane F. Burns, Neil J. Thomson Jan 2013

Review Of Ear Health And Hearing Among Indigenous Australians, Jane F. Burns, Neil J. Thomson

ECU Publications 2013

Indigenous Australians experience some of the highest levels of ear disease and hearing loss in the world, with rates up to ten times more than those for non-Indigenous Australians [4]. Children and adolescents are particularly vulnerable to ear infections. The most common ear disease among Indigenous children is otitis media (OM), which is inflammation/infection of the middle ear typically caused by bacterial and viral pathogens. Indigenous children living in urban, rural and, particularly, remote areas, are more likely than their non-Indigenous counterparts to have OM at younger ages, more often, at a greater level of severity, and with more ...


Repetitive Transcranial Magnetic Stimulation Used For Tinnitus Suppression: A Voxel-Based Morphometry Study, Lauren E. Laitman Jun 2011

Repetitive Transcranial Magnetic Stimulation Used For Tinnitus Suppression: A Voxel-Based Morphometry Study, Lauren E. Laitman

Honors Theses

Tinnitus is a debilitating disorder with unknown underlying mechanisms, often induced by loud noises. Tinnitus symptoms include the conscious perception of constant sound absent an external source. This study sought to determine effectiveness of treatment with repetitive transcranial magnetic stimulation (rTMS), and to use voxel-based morphometry (VBM) to identify treatment related neuronal reorganization. One hertz rTMS was delivered for 20 minutes on each of 5 consecutive days. Tinnitus suppression was measured with the Tinnitus Handicap Questionnaire (THQ), and VBM was carried out on structural Magnetic Resonance images collected before and after sham-treatment and rTMS. Findings indicate the effectiveness of rTMS ...


The Effectiveness And Safety Of Antibiotic Treatment In Healing Tympanic Membrane Perforation In Aboriginal Children, Shannon M. Rice Jan 2011

The Effectiveness And Safety Of Antibiotic Treatment In Healing Tympanic Membrane Perforation In Aboriginal Children, Shannon M. Rice

PCOM Physician Assistant Studies Student Scholarship

The objective of this systematic review is to determine whether or not antibiotic treatment is safe and effective in healing tympanic membrane (TM) perforation in Aboriginal children diagnosed with chronic suppurative otitis media and otitis media with effusion less than 16 years of age.


Topical Analgesia For Acute Otitis Media, Ruth Foxlee, Ann-Charlotte Johansson, Jessika Wejfalk, Liz Dooley, Chris Del Mar Sep 2010

Topical Analgesia For Acute Otitis Media, Ruth Foxlee, Ann-Charlotte Johansson, Jessika Wejfalk, Liz Dooley, Chris Del Mar

Liz Dooley

Background Acute otitis media (AOM) is a spontaneously remitting disease for which pain is the most distressing symptom. Antibiotics are now known to have less benefit than previously assumed. Objectives To assess the effectiveness of topical analgesia for AOM. Search strategy We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 2, 2006), MEDLINE (1966 to May Week 3 2006), EMBASE (1990 to December 2005) and LILACS (1982 to September 2005) without language restriction, and the reference lists of articles. We also contacted manufacturers and authors. Selection criteria Double-blind randomised or quasi-randomised controlled trials comparing an ...


Role Of Wfs1 In Regulating Endoplasmic Reticulum Stress Signaling: A Dissertation, Sonya G. Fonseca Feb 2009

Role Of Wfs1 In Regulating Endoplasmic Reticulum Stress Signaling: A Dissertation, Sonya G. Fonseca

GSBS Dissertations and Theses

The endoplasmic reticulum (ER) is a multi-functional cellular compartment that functions in protein folding, lipid biosynthesis, and calcium homeostasis. Perturbations to ER function lead to the dysregulation of ER homeostasis, causing the accumulation of unfolded and misfolded proteins in the cell. This is a state of ER stress. ER stress elicits a cytoprotective, adaptive signaling cascade to mitigate stress, the Unfolded Protein Response (UPR). As long as the UPR can moderate stress, cells can produce the proper amount of proteins and maintain a state of homeostasis. If the UPR, however, is dysfunctional and fails to achieve this, cells will undergo ...


Topical Analgesia For Acute Otitis Media, Ruth Foxlee, Ann-Charlotte Johansson, Jessika Wejfalk, Liz Dooley, Chris Del Mar Feb 2009

Topical Analgesia For Acute Otitis Media, Ruth Foxlee, Ann-Charlotte Johansson, Jessika Wejfalk, Liz Dooley, Chris Del Mar

Christopher Del Mar

Background Acute otitis media (AOM) is a spontaneously remitting disease for which pain is the most distressing symptom. Antibiotics are now known to have less benefit than previously assumed. Objectives To assess the effectiveness of topical analgesia for AOM. Search strategy We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 2, 2006), MEDLINE (1966 to May Week 3 2006), EMBASE (1990 to December 2005) and LILACS (1982 to September 2005) without language restriction, and the reference lists of articles. We also contacted manufacturers and authors. Selection criteria Double-blind randomised or quasi-randomised controlled trials comparing an ...


Cartilage Tissue Engineering: Uses Of Injection Molding And Computer Aided Design For The Fabrication Of Complex Geometries With High Dimensional Tolerances: A Dissertation, Morgan E. Hott May 2007

Cartilage Tissue Engineering: Uses Of Injection Molding And Computer Aided Design For The Fabrication Of Complex Geometries With High Dimensional Tolerances: A Dissertation, Morgan E. Hott

GSBS Dissertations and Theses

Cartilage Tissue Engineering. Joint pain and functional impairment due to cartilage damage from osteoarthritis and other means is a major source of disability for adults the world over. Cartilage is an avascular tissue with a very limited capacity for self repair. Current medical and surgical approaches to cartilage repair also have limited efficacy, and in all cases fail to completely restore a normal, healthy cartilage phenotype. Tissue engineering is a relatively new approach to cartilage repair that seeks to fabricate a replacement tissue, indistinguishable from healthy, native tissue.

The basic idea of the tissue engineering approach is to seed tissue ...