Eye Diseases Commons^™

Plantas Medicinales: Aspectos Básicos De Una Alternativa Terapéutica Emergente Para El Control De Las Infecciones Oculares Bacterianas, Wendy Johanna Velasco García, Ludy C. Pabón, Patricia Hernández-Rodríguez

Ciencia y Tecnología para la Salud Visual y Ocular

Las bacterias son los patógenos principales relacionados con infecciones que afectan las estructuras del ojo de forma intra- o extraocular; el género Staphylococcus es el grupo más prevalente asociado con este tipo de infección. Para el control de las infecciones oculares se utilizan antibióticos como oxacilina y meticilina, que en muchos casos llevan a la resistencia bacteriana. Además, el alto costo de los medicamentos, que en Colombia alcanzan cifras tres o cuatro veces mayores que en otros países, se constituyen en desventajas para su uso. Lo anterior ha llevado a estudiar la actividad antimicrobiana de las plantas frente a los …

Calidad Microbiológica Del Aire En Una Clínica Óptica, Nicolás Duarte, Sebastián Roa, Francy Méndez-C

Ciencia y Tecnología para la Salud Visual y Ocular

Introducción: el aire como fluido está presente en diferentes espacios. Es probable quecontenga diferentes contaminantes, incluyendo microorganismos patógenos, que, debidoa factores ambientales, se encuentran dispersos en el entorno hospitalario, donde son responsablesde causar enfermedades en poblaciones vulnerables. Además de ser consideradascomo un riesgo para la salud, las enfermedades nosocomiales generan costos de tratamientomuy altos, que varían de 13 a 15 millones de pesos por enfermedad durante el tratamiento.Objetivo: determinar la calidad microbiológica del aire en los baños, los pasillos, la recepcióny algunos espacios de almacenamiento de una clínica óptica en Colombia. Método: serealizó una visita inicial a la clínica para …

Endoftalmitis Infecciosa Postraumática: Reporte De Caso, Yhisetd Gerardine Parada Jaimes, Manuel Fernando Buitrago

Ciencia y Tecnología para la Salud Visual y Ocular

Introducción: la endoftalmitis es una inflamación severa del globo ocular; su mayor prevalencia es la exógena posquirúrgica; actualmente se evidencian pocos casos reportados por endoftalmitis infecciosa exógena postraumática por agente micótico; además, se tiene un factor de riesgo en su evolución, como lo es la diabetes mellitus tipo 2. Objetivo: describir las características nosológicas de la endoftalmitis postraumática. Métodos: se realizó un estudio observacional descriptivo tipo reporte de caso, que acogió los principios éticos de la declaración de Helsinki y la Resolución 8430 de 1993. Resultados: paciente masculino de 51 años de edad, de procedencia rural, ocupación agricultor; asiste al …

Actualización En Carcinoma Basocelular Periocular: Abordaje Semiológico Y Diagnóstico Diferencial, Luis Miguel Amaya Nieto, Luisa Fernanda Sierra Patiño, Héctor Horacio Pérez Estepa

Ciencia y Tecnología para la Salud Visual y Ocular

Introducción: este artículo se basa en la revisión y profundización de conceptos actuales rela¬cionados con la semiología clínica y el diagnóstico diferencial, referentes al carcinoma basoce¬lular periocular (CBPO). Objetivo: describir las características semiológicas y los diagnósticos diferenciales del CBPO. Metodología: se realizó una revisión de literatura en las bases de datos ScienceDirect, BVS, Pubmed, SciELO y EBSCO/Medline, mediante los términos MeSH y DeCS “carcinoma”, “basal cell” y “carcinoma basocelular”, con el operador booleano “and” y el término “periocular”, en el periodo 2012-2018. Según el total de estudios relacionados con los términos de la búsqueda, fueron seleccionados artículos escritos en francés, …

Optometría: Retos Y Oportunidades Hacia Futuro, Nancy Piedad Molina-Montoya

Ciencia y Tecnología para la Salud Visual y Ocular

No abstract provided.

For Your Eyes Only, Herpes Zoster Ophthalmicus Case Study, Alexander Fishman, Jared Ward, Richard Pescatore

Stratford Campus Research Day

Herpes Zoster Ophthalmicus is a reactivation of a latent Varicella Zoster Virus that specifically involves the eye. The reactivation often occurs during immunocompromised states which allows latent virus in the dorsal root ganglia of sensory nerves to begin viral replication an d s pread via peripheral axons. Diagnosis is based on two characteristic findings; herpetic lesions on the eyelids, forehead, or elsewhere within the V1 dermatome, and ocular findings. Symptoms can vary but are often quite painful. Some patients experience a prodrome of tingling sensation prior to the appearance of a zoster dermatitis . HZO can also present initially as …

Seeing Eye To Eye: A Machine Learning Approach To Automated Saccade Analysis, Maigh Attre

Honors Scholar Theses

Abnormal ocular motility is a common manifestation of many underlying pathologies particularly those that are neurological. Dynamics of saccades, when the eye rapidly changes its point of fixation, have been characterized for many neurological disorders including concussions, traumatic brain injuries (TBI), and Parkinson’s disease. However, widespread saccade analysis for diagnostic and research purposes requires the recognition of certain eye movement parameters. Key information such as velocity and duration must be determined from data based on a wide set of patients’ characteristics that may range in eye shapes and iris, hair and skin pigmentation [36]. Previous work on saccade analysis has …

The Proliferation Of Porcine Retinal Ganglion Cells Using Pnu 282987, Rebecca Karl, David Linn

Honors Projects

The retinal ganglion cells (RGCs) from porcine eyes were extracted to work towards a potential therapy for glaucoma. There is not a known cause of glaucoma or the apoptosis of RGCs that cause the eventual blindness associated with glaucoma. The goal of this protocol is to protect the RGCs from dying by adding a nicotinic acetylcholine receptor activator to induce neuronal proliferation and protect against glutamate-induced excitotoxicity. PNU 282987 was used as the nicotinic acetylcholine receptor activator due to its neuroprotective properties. We hypothesized that we would observe the proliferation of RGCs (associated with increased cell numbers) with varying levels …

Myopia Outcome Study Of Atropine In Children (Mosaic): Design And Methodology, Saoirse Mccrann, Ian Flitcroft, John Butler, James Loughman

Articles

Purpose

The Myopia Outcome Study of Atropine in Children (MOSAIC) aims to explore the efficacy, safety, acceptability and mechanisms of action of 0.01% atropine for myopia control in a European population.

Methods

MOSAIC is an investigator-led, double-masked, placebo-controlled, randomised clinical trial investigating the efficacy, safety and mechanisms of action of 0.01% atropine eyedrops in myopic progression management. During phase 1 of the trial, 250 children aged 6-16 years with progressive myopia apply eye drops once nightly in both eyes from randomisation to month 24. No treatment is given during phase 2 from month 24 to 36 (washout period) for those …

Nutrigenomics Of Age-Related Macular Degeneration, Durpri Lin

Master of Chemical Sciences Capstone Projects

Lutein (L) and zeaxanthin (Z) are nutrients that reduce the risk of age-related macular degeneration (AMD). As micronutrients that selectively accumulate in the retina of the eye, L/Z can protect the macula from oxidative damage that contributes to AMD. This review will discuss the role of genes as a mediator between increased intake of dietary L/Z and decreased risk of AMD. Figure 1 outlines a pathway of L/Z that is subject to genetic influences, from 1) the diet to 2) the bloodstream to 3) the retina of the eye. First, L/Z are carotenoids that cannot be synthesized de novo and …

The Tumor Microenvironment Regulates Retinoblastoma Cell Survival, Zachary K. Goldsmith

Theses and Dissertations (ETD)

Retinoblastoma (Rb) is the most common intraocular malignancy in children comprising 4% of all pediatric tumors. Early intervention increases survival rates up to 95% in developed countries; being survival rates associated to socio-economic status. Despite the high survival rates in developed countries, preservation of the eye and vision are continuing challenges in the management of Rb. Vitreous seeds constitute the greatest challenge in treatment of Rb. The unique location of these seeds within the vitreous makes them difficult to treat. Viable seeds showed reduced proliferative capacity and metabolism. making the majority refractory to current chemotherapeutics. This prompted the development of …

Eye Tissue Regeneration: Seam As A Cure For Prevalent Eye Disease, Molly Bute

Biology: Student Scholarship & Creative Works

SEAM (Self-formed ectodermal autonomous multizone) is a form of eye tissue regeneration discovered by Japanese scientists in 2016. This tissue regeneration encompasses tissues from all areas of the human eye. The SEAM forms tissues using stem cells, induced pluripotent stem cells were used in the first study, and produces four concentric zones. The SEAM that has been created was shown to cure corneal blindness in animal models, and has the potential to cure a multitude of human eye diseases in the future.

Genetic Modification Of Inherited Retinopathy In Mice, Yang Kong

Electronic Theses and Dissertations

The retina, as a critical component of the sensory system, consists of multiple cell types, of which, photoreceptors play a key role in receiving, integrating and transmitting light signals. The biofunctions of photoreceptors rely on their proper growth and development, which is predominantly governed by a cluster of molecules that comprise the transcriptional regulation for photoreceptor development. Any disruption of these molecules potentially incurs retinal pathologies.

It is known that deficiencies of nuclear receptor subfamily 2 group E member 3 (NR2E3) or neural retina leucine-zipper (NRL), two molecules in regulating photoreceptor cell development, cause photoreceptor dysplasia. In a sensitized chemical …

Role Of Long Noncoding Rnas In Diabetic Complications, Anu Alice Thomas

Electronic Thesis and Dissertation Repository

LncRNAs, recently found to be pervasively transcribed in the genome, can play key roles in epigenetic modifications during gene transcription. Their role in diabetic complications are however not clear.

Using array analysis, we identified alterations of two lncRNAs in high glucose (25mM/L,HG) treated retinal endothelial cells (HRECs). ANRIL expressions were further measured with or without siRNA knockdown in ECs. ANRIL knockout (KO) mice with or without streptozotocin (STZ)-induced diabetes were also investigated for mRNA and protein expression of VEGF and ECM proteins FN and Col1α4. ANRIL knockdown prevented glucose-induced increased VEGF, FN and Col1α4 levels. Comparable results were observed in …

An Active Efficient Coding Model Of The Development Of Amblyopia, Samuel Eckmann, Lukas Klimmasch, Bertram Shi, Jochen Triesch

MODVIS Workshop

No abstract provided.

Functional And Structural Impact Of The Loss Of The Leucine-Rich Repeat Protein Lrit1 In The Mouse Retina., Catherine Ann Cobb

Electronic Theses and Dissertations

Mutations in genes encoding the leucine-rich repeat (LRR) proteins nyctalopin and LRIT3 lead to complete congenital stationary night blindness because they are critical to depolarizing bipolar cell function in the retina. LRIT3 has two closely related family members, LRIT1 and LRIT2. In silico analyses of publicly available RNA-Seq data showed that Lrit1 was highly expressed in the retina. Here I describe the expression pattern and impact of loss of LRIT1 on retinal function. To enable these studies, we used CRISPR/Cas9 technology to create an Lrit1^-/- mouse line. Retinal morphology and morphometry analyses showed no gross changes in retinal structure …

Differential Diagnosis Of Pan-Uveitis: Behçet’S Disease, Peter Blosser, Remil Simon, Courtney Ridner

Appalachian Student Research Forum

This report describes the case of a 56-year-old man who presented with blurry vision, increased intraocular pressure, and conjunctival injection after posterior chamber intraocular lens implantation. Initially post-operative endophalmitis and foreign body inflammation were considered as differential diagnoses, but after further examination pan-uveitis was diagnosed. Uveitis is an ocular finding that may indicate several diseases, one of which is Behçet’s Disease. During the interview, the patient mentioned a history of apthous ulcers and genital ulcers which then lead to the clinical diagnosis of Behçet’s Disease. This report emphasizes that Behçet’s Disease is rare in Caucasians. Therefore, is frequently misdiagnosed in …

Reduced Intraepithelial Corneal Nerve Density And Sensitivity Accompany Desiccating Stress And Aging In C57bl/6 Mice, Mary Ann Stepp, Sonali Pal-Ghosh, Gauri Tadvalkar, Alexa Williams, S Pflugfelder, C De Paiva

Anatomy and Regenerative Biology Faculty Publications

Dry Eye disease causes discomfort and pain in millions of patients. Using a mouse acute desiccating stress (DS) model we show that DS induces a reduction in intraepithelial corneal nerve (ICN) density, corneal sensitivity, and apical extension of the intraepithelial nerve terminals (INTs) that branch from the subbasal nerves (SBNs). Topical application of 0.02% Mitomycin C (MMC) or vehicle alone has no impact on the overall loss of axon density due to acute DS. Chronic dry eye, which develops progressively as C57BL/6 mice age, is accompanied by significant loss of the ICNs and corneal sensitivity between 2 and 24 months …

Pilot Study Of Anxiety, Depression, And Quality Of Life In Patients With The Diagnosis Of Metastatic Uveal Melanoma, Regine Nshimiyimana, Dnp, Bpharm, Fnp-Bc, Agacnp-Bc, Ocn, Aocnp

Doctor of Nursing Practice Projects

Background: Awareness of a patient’s anxiety, depression, and quality of life (QOL) in those with metastatic uveal melanoma (MUM) can influence care that meets patients’ bio-psychosocial-spiritual needs.

Objectives: To measure the level of anxiety, depression, and QOL in patients with MUM and explore differences by gender, age range, time to metastatic disease, and duration of illness since metastasis.

Methods: We used a descriptive-comparative survey design. Over three months, a convenience sample of 70 patients with MUM aged ≥ 18 years, treated at a Mid-Atlantic hospital were invited to complete a combined survey of the Hospital Anxiety and Depression Scale and …

Slt Versus Alt In Glaucoma Patients Treated Previously With 360-Degree Slt—A Randomised, Single-Blind, Equivalence Clinical Trial, Hui Guo

Electronic Thesis and Dissertation Repository

Our objectives were to compare the efficacy and safety between selective laser trabeculoplasty (SLT) and argon laser trabeculoplasty (ALT) for the open-angle glaucoma patients who had 360-degree SLT previously and to explore the baseline predictors for the treatment success. Data were obtained from a multicenter, patient-masked, randomised, parallel-group, active-controlled trial. The enrolled patients were randomly assigned to receive either SLT or ALT. At 12-month follow-up, the mean intraocular pressure (IOP) reduction was 3.35 mmHg and 3.36 mmHg after SLT and ALT respectively. The difference of mean IOP reduction was -0.01 mmHg (n=115). The 95% CI of the difference was between …