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Endocrine System Diseases Commons

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Articles 1 - 30 of 468

Full-Text Articles in Endocrine System Diseases

The Effects Of Continuous Insulin Pump Therapy On Glycemic Control In Pregnant Type 1 Diabetics, Kimberly Kelsey Dec 2017

The Effects Of Continuous Insulin Pump Therapy On Glycemic Control In Pregnant Type 1 Diabetics, Kimberly Kelsey

Senior Theses and Capstone Projects

Type 1 Diabetics have various ways of managing their diabetes that have been studied for their effectiveness. Pregnancy in the Type 1 Diabetic has been understudied. It is known that Diabetics in general have poorer pregnancy outcomes because of poor glycemic control. This coupled with the fact that the body needs 3-4 times more insulin as pregnancy comes to an end makes managing blood glucose levels challenging for diabetics (Lowdermilk, 2016, p. 689). For the Type 1 Diabetic, there are two main ways to control diabetes: multiple daily injections using at least two type of insulin and continuous subcutaneous insulin ...


A Low Carbohydrate, Ketogenic Diet For Treatment Of Type Ii Diabetes An Integrative Literature Review, Steven Lisowski Nov 2017

A Low Carbohydrate, Ketogenic Diet For Treatment Of Type Ii Diabetes An Integrative Literature Review, Steven Lisowski

Grace Peterson Nursing Research Colloquium

A Low Carbohydrate, Ketogenic Diet for Treatment

of Type II Diabetes: An Integrative Literature Review

Steven Lisowski

Faculty Sponsor: Larry Maturin

Abstract

Background: Dietary modifications are commonly prescribed initial interventions in those recently diagnosed with type II diabetes. Presently, various researchers support that there is a growing body of evidence that advises to restrict carbohydrate intake to minimum levels to achieve optimal blood glucose levels and reduce complications related to poor diabetes management.

Objectives: To explore if the low carbohydrate, ketogenic diets (LCKD), in which carbohydrate intake of any kind is restricted, are very effective at reducing obesity and controlling ...


Sick Days - English, Michele Spatz, Ruth Dallas Oct 2017

Sick Days - English, Michele Spatz, Ruth Dallas

Diabetes Patient Education Tools

This one page handout offers tips on what to do when you are sick and you have diabetes. (English)


What About Alcohol And Diabetes? - Spanish, Michele Spatz, Ruth Dallas Oct 2017

What About Alcohol And Diabetes? - Spanish, Michele Spatz, Ruth Dallas

Diabetes Patient Education Tools

One page handout discusses the effects of drinking alcohol on diabetes. (Spanish)


What About Alcohol And Diabetes? - English, Michele Spatz, Ruth Dallas Oct 2017

What About Alcohol And Diabetes? - English, Michele Spatz, Ruth Dallas

Diabetes Patient Education Tools

This one page handout discusses the effects of drinking alcohol on diabetes.


Sick Days - Spanish, Michele Spatz, Ruth Dallas Oct 2017

Sick Days - Spanish, Michele Spatz, Ruth Dallas

Diabetes Patient Education Tools

This one page handout offers tips on what to do when you are sick and you have diabetes. (Spanish)


Temporal Changes In Cortical And Hippocampal Expression Of Genes Important For Brain Glucose Metabolism Following Controlled Cortical Impact Injury In Mice, June Zhou, Mark Burns, Linda Huynh, Sonia Villapol, Daniel D. Taub, Juan M. Saavedra, Marc R. Blackman Sep 2017

Temporal Changes In Cortical And Hippocampal Expression Of Genes Important For Brain Glucose Metabolism Following Controlled Cortical Impact Injury In Mice, June Zhou, Mark Burns, Linda Huynh, Sonia Villapol, Daniel D. Taub, Juan M. Saavedra, Marc R. Blackman

Pharmacology and Physiology Faculty Publications

Traumatic brain injury (TBI) causes transient increases and subsequent decreases in brain glucose utilization. The underlying molecular pathways are orchestrated processes and poorly understood. In the current study, we determined temporal changes in cortical and hippocampal expression of genes important for brain glucose/lactate metabolism and the effect of a known neuroprotective drug telmisartan on the expression of these genes after experimental TBI. Adult male C57BL/6J mice (n = 6/group) underwent sham or unilateral controlled cortical impact (CCI) injury. Their ipsilateral and contralateral cortex and hippocampus were collected 6 h, 1, 3, 7, 14, 21, and 28 days after ...


Care For Diabetic Population, Jennifer Aronson, Leanne Bellino, Elizabeth Eisenhardt, Diane Bryant, Haley Pelletier, Internal Medicine Team, Adult Outpatient Clinic Aug 2017

Care For Diabetic Population, Jennifer Aronson, Leanne Bellino, Elizabeth Eisenhardt, Diane Bryant, Haley Pelletier, Internal Medicine Team, Adult Outpatient Clinic

Maine Medical Center

No abstract provided.


Pursuing Equity In Diabetes Population, Aisha Rawlinson Aug 2017

Pursuing Equity In Diabetes Population, Aisha Rawlinson

Master's Projects and Capstones

Abstract

Background

Poor glycemic control (HbA1c >8) overtime leads to microvascular and macrovascular complications after the first and third years respectively, ultimately resulting in death after five years (Karter, 2016). Current Kaiser Permanente (KP) data stratified by race, ethnicity, age, and gender shows a significant disparity gap between Hispanics/Latino and Caucasian populations. The Pursuing IHI initiative is over a 2-year period completed at a microsystem that is focusing on health equity practices to reduce disparity gaps.

Project aim

KP Riverside, microsystem selected has a large population of Hispanic/Latino KP members, with focus on health equity. The project aim ...


Type Ii Diabetes, Michelle Irwin Jul 2017

Type Ii Diabetes, Michelle Irwin

Master of Science in Nursing (MSN) Student Scholarship

The chosen topic to research is Diabetes Mellitus Type II (DMII). DMII has become a rampant disease in the United States and is becoming more common. The United States has an alarming rate of new diagnosis of DMII (Chen, 2012). One of the most disappointing facts is that it can be prevented. DMII is not a disease that one has to have for a lifetime. An important detail of this disease is that it has so many comorbidities. Many people in the general population think that they can just take a pill or take insulin to control it. However, even ...


Plk2 Plays An Essential Role In High D-Glucose-Induced Apoptosis, Ros Generation And Inflammation In Podocytes., Hong-Hong Zou, Ping-Ping Yang, Tian-Lun Huang, Xiao-Xu Zheng, Gao-Si Xu Jun 2017

Plk2 Plays An Essential Role In High D-Glucose-Induced Apoptosis, Ros Generation And Inflammation In Podocytes., Hong-Hong Zou, Ping-Ping Yang, Tian-Lun Huang, Xiao-Xu Zheng, Gao-Si Xu

Medicine Faculty Publications

Diabetic kidney disease (DKD) is a serious complication of hyperglycemia. Currently, there is no effective therapeutic intervention for DKD. In this study, we sought to provide a set of gene profile in diabetic kidneys. We identified 338 genes altered in diabetes-induced DKD glomeruli, and PLK2 exhibited the most dramatic change. Gene set enrichment analysis (GSEA) indicated multiple signaling pathways are involved DKD pathogenesis. Here, we investigated whether PLK2 contributes to podocyte dysfunction, a characteristic change in the development of DKD. High D-glucose (HDG) significantly increased PLK2 expression in mouse podocytes. Suppressing PLK2 attenuated HDG-induced apoptosis and inflammatory responses both in ...


Possible Type 1 Diabetes Risk Prediction: Using Ultrasound Imaging To Assess Pancreas Inflammation In The Inducible Autoimmune Diabetes Bbdr Model, Frederick R. Roberts, Clinton Hupple, Elaine Norowski, Nicole C. Walsh, Natalia Przewozniak, Ken-Edwin Aryee, Filia M. Van Dessel, Agata Jurczyk, David M. Harlan, Dale L. Greiner, Rita Bortell, Chaoxing Yang Jun 2017

Possible Type 1 Diabetes Risk Prediction: Using Ultrasound Imaging To Assess Pancreas Inflammation In The Inducible Autoimmune Diabetes Bbdr Model, Frederick R. Roberts, Clinton Hupple, Elaine Norowski, Nicole C. Walsh, Natalia Przewozniak, Ken-Edwin Aryee, Filia M. Van Dessel, Agata Jurczyk, David M. Harlan, Dale L. Greiner, Rita Bortell, Chaoxing Yang

Open Access Articles

BACKGROUND/AIMS: Studies of human cadaveric pancreas specimens indicate that pancreas inflammation plays an important role in type 1 diabetes pathogenesis. Due to the inaccessibility of pancreas in living patients, imaging technology to visualize pancreas inflammation is much in need. In this study, we investigated the feasibility of utilizing ultrasound imaging to assess pancreas inflammation longitudinally in living rats during the progression leading to type 1 diabetes onset.

METHODS: The virus-inducible BBDR type 1 diabetes rat model was used to systematically investigate pancreas changes that occur prior to and during development of autoimmunity. The nearly 100% diabetes incidence upon virus ...


Donor Diabetes And Prolonged Cold Ischemia Time Synergistically Increase The Risk Of Graft Failure After Liver Transplantation, Isabel M. A. Bruggenwirth, Natasha H. Dolgin, Robert J. Porte, Adel Bozorgzadeh, Paulo N.A. Martins Jun 2017

Donor Diabetes And Prolonged Cold Ischemia Time Synergistically Increase The Risk Of Graft Failure After Liver Transplantation, Isabel M. A. Bruggenwirth, Natasha H. Dolgin, Robert J. Porte, Adel Bozorgzadeh, Paulo N.A. Martins

Open Access Articles

BACKGROUND: Both prolonged cold ischemia time (CIT) and donor history of diabetes mellitus (DM) are associated with reduced graft survival after liver transplantation. However, it is unknown whether the adverse effect of prolonged CIT on posttransplant graft survival is more pronounced after transplant with DM versus non-DM donor grafts.

METHODS: The study sample included 58 226 liver transplant recipients (2002-2015) from the Scientific Registry of Transplant Recipients. Multivariable Cox survival regression with interaction analysis was used to quantify the extent to which history of donor DM (n = 6478) potentiates the adverse effect of prolonged ( > /=8 hours) CIT (n = 18 287 ...


Snail-Cathepsin L Signaling In Human Breast And Prostate Cancers, Lizajoy Burton May 2017

Snail-Cathepsin L Signaling In Human Breast And Prostate Cancers, Lizajoy Burton

Electronic Theses & Dissertations Collection for Atlanta University & Clark Atlanta University

Prostate and breast cancer are the leading causes of cancer-related death in men and women, respectively, and metastasis is the primary factor underlying the high mortality rates.1 Snail transcription factor is an important molecule that drives prostate and breast cancer metastasis through the process of epithelial mesenchymal transition (EMT). Proteolytic enzymes that promote invasion and metastasis such as the lysosomal cysteine protease cathepsin L (Cat L) have been shown to degrade E-cadherin, promoting the epithelial mesenchymal transition (EMT).2 It has also been shown that silencing Cat L can inhibit transforming growth factor-beta (TGF-β)-mediated EMT by suppressing Snail ...


The Effectiveness Of Tablet-Based Application For Older Adults With Diabetes Mellitus Type Ii: A Pilot Study, Mohammad Alkawaldeh, Jacelon Cynthia, Jeungok Choi, Jenna Marquard, John Ridgway May 2017

The Effectiveness Of Tablet-Based Application For Older Adults With Diabetes Mellitus Type Ii: A Pilot Study, Mohammad Alkawaldeh, Jacelon Cynthia, Jeungok Choi, Jenna Marquard, John Ridgway

UMass Center for Clinical and Translational Science Research Retreat

Introduction: Advances in technological applications such as tablet-based computers is growing dramatically in the field of healthcare, as there is a considerable eagerness for mobile health interventions. Tablet-based interventions can have positive effects on both health and health service delivery processes (Free et al, 2013). Technological applications have been developed for a wide range of healthcare needs, including patient registration, data management, and self- management applications.

Background: The usefulness of technology and the powerful capabilities of technological applications have led to a significantly increased interest in finding novel approaches to support older adults’ self-management.Self-management technological applications have been used ...


Prolonged Exercise And Its Effects On Type 1 Diabetes Mellitus, Laurel G. Markert May 2017

Prolonged Exercise And Its Effects On Type 1 Diabetes Mellitus, Laurel G. Markert

Honors Theses AY 16/17

Type 1 diabetes mellitus is presumably caused by immunological or viral cumulative destruction of pancreatic β cells, leading to a complete inability to produce endogenous insulin. Exercise can cause different reactions in relation to blood glucose concentration, depending on duration and intensity. High intensity aerobic workouts can cause blood glucose to drop. Anaerobic exercise can cause blood glucose to rise. This can cause problems for a diabetic patient in terms of diabetes management during exercise, as patients often over-compensate for an expected glucose drop by eating carbohydrates and taking a reduced bolus amount of insulin (or no insulin at all ...


A Predictive Model For Lack Of Partial Clinical Remission In New-Onset Pediatric Type 1 Diabetes, Katherine R. Marino, Rachel L. Lundberg, Aastha Jasrotia, Louise Maranda, Michael J. Thompson, Bruce A. Barton, Laura C. Alonso, Benjamin U. Nwosu May 2017

A Predictive Model For Lack Of Partial Clinical Remission In New-Onset Pediatric Type 1 Diabetes, Katherine R. Marino, Rachel L. Lundberg, Aastha Jasrotia, Louise Maranda, Michael J. Thompson, Bruce A. Barton, Laura C. Alonso, Benjamin U. Nwosu

Benjamin U. Nwosu

IMPORTANCE: >50% of patients with new-onset type 1 diabetes (T1D) do not enter partial clinical remission (PCR); early identification of these patients may improve initial glycemic control and reduce long-term complications. AIM: To determine whether routinely obtainable clinical parameters predict non-remission in children and adolescents with new-onset T1D. SUBJECTS AND METHODS: Data on remission were collected for the first 36 months of disease in 204 subjects of ages 2-14 years with new-onset type 1 diabetes. There were 86 remitters (age 9.1±3.0y; male 57%), and 118 non-remitters (age 7.0±3.1y; male 40.7%). PCR was defined ...


Basic Diabetes Class Handout With Goal Numbers - English, Michele Spatz, Ruth Dallas May 2017

Basic Diabetes Class Handout With Goal Numbers - English, Michele Spatz, Ruth Dallas

Diabetes Patient Education Tools

This diabetic patient handout reviews A1C test results and simply illustrates what the patient can do to keep his/her blood sugar levels in the goal range.


Basic Diabetes Class Handout Without Goals - English, Michele Spatz, Ruth Dallas May 2017

Basic Diabetes Class Handout Without Goals - English, Michele Spatz, Ruth Dallas

Diabetes Patient Education Tools

This diabetic patient handout reviews A1C test results and simply illustrates what the patient can do to stay healthy.


Basic Diabetes Class Handout Without Goals - Spanish, Michele Spatz, Ruth Dallas May 2017

Basic Diabetes Class Handout Without Goals - Spanish, Michele Spatz, Ruth Dallas

Diabetes Patient Education Tools

This diabetic patient handout reviews A1C test results and simply illustrates what the patient can do to stay healthy. (Spanish)


A Predictive Model For Lack Of Partial Clinical Remission In New-Onset Pediatric Type 1 Diabetes, Katherine R. Marino, Rachel L. Lundberg, Aastha Jasrotia, Louise Maranda, Michael J. Thompson, Bruce A. Barton, Laura C. Alonso, Benjamin U. Nwosu May 2017

A Predictive Model For Lack Of Partial Clinical Remission In New-Onset Pediatric Type 1 Diabetes, Katherine R. Marino, Rachel L. Lundberg, Aastha Jasrotia, Louise Maranda, Michael J. Thompson, Bruce A. Barton, Laura C. Alonso, Benjamin U. Nwosu

Endocrinology/Diabetes

IMPORTANCE: >50% of patients with new-onset type 1 diabetes (T1D) do not enter partial clinical remission (PCR); early identification of these patients may improve initial glycemic control and reduce long-term complications.

AIM: To determine whether routinely obtainable clinical parameters predict non-remission in children and adolescents with new-onset T1D.

SUBJECTS AND METHODS: Data on remission were collected for the first 36 months of disease in 204 subjects of ages 2-14 years with new-onset type 1 diabetes. There were 86 remitters (age 9.1±3.0y; male 57%), and 118 non-remitters (age 7.0±3.1y; male 40.7%). PCR was defined ...


Blood Glucose Goals - Spanish, Michele Spatz, Ruth Dallas May 2017

Blood Glucose Goals - Spanish, Michele Spatz, Ruth Dallas

Diabetes Patient Education Tools

Simple, one page handout illustrating blood glucose goals. (Spanish)


Blood Glucose Log 4x/Day - Spanish, Michele Spatz, Ruth Dallas May 2017

Blood Glucose Log 4x/Day - Spanish, Michele Spatz, Ruth Dallas

Diabetes Patient Education Tools

A simple log to record blood glucose levels 4 times/day for diabetics. (Spanish)


Food Label - English, Michele Spatz, Ruth Dallas May 2017

Food Label - English, Michele Spatz, Ruth Dallas

Diabetes Patient Education Tools

Illustrated food label for diabetics to explain how to identify total carbohydrates.


Food Label - Spanish, Michele Spatz, Ruth Dallas May 2017

Food Label - Spanish, Michele Spatz, Ruth Dallas

Diabetes Patient Education Tools

Illustrated food label for diabetics to explain how to identify total carbohydrates. (Spanish)


Foot Care - English, Michele Spatz, Ruth Dallas May 2017

Foot Care - English, Michele Spatz, Ruth Dallas

Diabetes Patient Education Tools

A simple, illustrated handout explaining foot care for diabetes patients.


Blood Glucose Log 4x/Day - English, Michele Spatz, Ruth Dallas May 2017

Blood Glucose Log 4x/Day - English, Michele Spatz, Ruth Dallas

Diabetes Patient Education Tools

A simple log to record blood glucose levels 4 times/day for diabetics. (English and Spanish)


Healthy Plate - Spanish, Michele Spatz, Ruth Dallas May 2017

Healthy Plate - Spanish, Michele Spatz, Ruth Dallas

Diabetes Patient Education Tools

Healthy eating tips for diabetics using the Healthy Plate. (Spanish)


Carbs Portion Patient Handout - English, Michele Spatz, Ruth Dallas May 2017

Carbs Portion Patient Handout - English, Michele Spatz, Ruth Dallas

Diabetes Patient Education Tools

For meal planning, this picture-based patient education handout explains how many grams of carbohydrates and the equivalent Tablespoons of sugar are found in portions of common foods.


Blood Glucose Goals - English, Michele Spatz, Ruth Dallas May 2017

Blood Glucose Goals - English, Michele Spatz, Ruth Dallas

Diabetes Patient Education Tools

Simple, one page handout illustrating blood glucose goals.