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The Feedforward And Feedback Controls On Gait In Adults With Diabetes, Chun-Kai Huang 2015 University of Nebraska Medical Center

The Feedforward And Feedback Controls On Gait In Adults With Diabetes, Chun-Kai Huang

Theses & Dissertations

There are nearly 26 million people with diabetes mellitus (DM) in the US, and half of chronic DMs develop somatosensory deficits due to diabetic polyneuropathy or diabetic peripheral neuropathy (DPN). The absence or impaired somatosensory feedback (e.g. touch sensation or joint proprioception) resulted from the damage of large nerve fiber, and motor deficits such as attenuated muscle strength and abnormal plantar pressure of lower extremity have been identified in DPN, and these sensorimotor impairments lead to an increased number of falls. To reduce the risk of falling, a well-coordinated and adapted limb movement driven by the feedforward (anticipatory) and ...


Gating Of The Polycystin Ion Channel Signaling Complex In Neurons And Kidney Cells, Patrick Delmas, Surya Nauli, Xiaogang Li, Bertrand Coste, Nancy Osorio, Marcel Crest, David Brown, Jing Zhou 2015 IFR Jean Roche

Gating Of The Polycystin Ion Channel Signaling Complex In Neurons And Kidney Cells, Patrick Delmas, Surya Nauli, Xiaogang Li, Bertrand Coste, Nancy Osorio, Marcel Crest, David Brown, Jing Zhou

David C. Brown

Mutations in either polycystin-2 (PC2) or polycystin-1 (PC1) proteins cause severe, potentially lethal, kidney disorders and multiple extrarenal (including brain) disease phenotypes. PC2, a member of the transient receptor potential channel superfamily, and PC1, an orphan membrane receptor of largely unknown function, are thought to be part of a common signaling pathway. Here, we show that in rat sympathetic neurons and kidney cells, coassembly of full-length PC1 with PC2 forms a plasmalemmal ion channel signaling complex in which PC1 stimulation simultaneously activates PC2 ion channels and G(i/o)-proteins. PC2 activation occurs through a structural rearrangement of PC1, independent ...


Determinants Of Racial/Ethnic Disparities In Incidence Of Diabetes In Postmenopausal Women In The U.S.: The Women's Health Initiative 1993-2009, Yunsheng Ma, James R. Hebert, JoAnn E. Manson, Raji Balasubramanian, Simin Liu, Michael J. Lamonte, Chloe E. Bird, Judith K. Ockene, Yongxia Qiao, Barbara C. Olendzki, Kristin L. Schneider, Milagros C. Rosal, Deidre M. Sepavich, Jean Wactawski-Wende, Marcia L. Stefanick, Lawrence S. Phillips, Ira S. Ockene, Robert C. Kaplan, Gloria E. Sarto, Lorena Garcia, Barbara V. Howard 2015 University of Massachusetts Medical School

Determinants Of Racial/Ethnic Disparities In Incidence Of Diabetes In Postmenopausal Women In The U.S.: The Women's Health Initiative 1993-2009, Yunsheng Ma, James R. Hebert, Joann E. Manson, Raji Balasubramanian, Simin Liu, Michael J. Lamonte, Chloe E. Bird, Judith K. Ockene, Yongxia Qiao, Barbara C. Olendzki, Kristin L. Schneider, Milagros C. Rosal, Deidre M. Sepavich, Jean Wactawski-Wende, Marcia L. Stefanick, Lawrence S. Phillips, Ira S. Ockene, Robert C. Kaplan, Gloria E. Sarto, Lorena Garcia, Barbara V. Howard

Barbara C. Olendzki

OBJECTIVE: To examine determinants of racial/ethnic differences in diabetes incidence among postmenopausal women participating in the Women's Health Initiative.

RESEARCH DESIGN AND METHODS: Data on race/ethnicity, baseline diabetes prevalence, and incident diabetes were obtained from 158,833 women recruited from 1993-1998 and followed through August 2009. The relationship between race/ethnicity, other potential risk factors, and the risk of incident diabetes was estimated using Cox proportional hazards models from which hazard ratios (HRs) and 95% CIs were computed.

RESULTS: Participants were aged 63 years on average at baseline. The racial/ethnic distribution was 84.1% non-Hispanic white ...


Marginal Structural Models For The Estimation Of The Risk Of Diabetes Mellitus In The Presence Of Elevated Depressive Symptoms And Antidepressant Medication Use In The Women's Health Initiative Observational And Clinical Trial Cohorts, Christine Frisard, Xiangdong Gu, Brian Whitcomb, Yunsheng Ma, Penelope Pekow, Martha Zorn, Deidre Sepavich, Raji Balasubramanian 2015 University of Massachusetts Medical School

Marginal Structural Models For The Estimation Of The Risk Of Diabetes Mellitus In The Presence Of Elevated Depressive Symptoms And Antidepressant Medication Use In The Women's Health Initiative Observational And Clinical Trial Cohorts, Christine Frisard, Xiangdong Gu, Brian Whitcomb, Yunsheng Ma, Penelope Pekow, Martha Zorn, Deidre Sepavich, Raji Balasubramanian

Yunsheng Ma

BACKGROUND: We evaluate the combined effect of the presence of elevated depressive symptoms and antidepressant medication use with respect to risk of type 2 diabetes among approximately 120,000 women enrolled in the Women's Health Initiative (WHI), and compare several different statistical models appropriate for causal inference in non-randomized settings.

METHODS: Data were analyzed for 52,326 women in the Women's Health Initiative Clinical Trials (CT) Cohort and 68,169 women in the Observational Study (OS) Cohort after exclusions. We included follow-up to 2005, resulting in a median duration of 7.6 years of follow up after enrollment ...


Sleep Duration Is Associated With Degree Of Insulin Resistance In A High Risk Population: The Baptist Employee Healthy Heart Study, Shozab Ali, Ebenezer Oni, Ehimen Aneni, Lara Roberson, Janisse Post, Gagandeep Nagi, Sameer Shaharyar, Omar Jamal, Rehan Malik, Muhammad Aziz, Adnan Younus, Beatriz Rosell, Henry Guzman, Ricardo Cury, Jonathan Fialkow, Arthur Agatston, Emir Veledar, Theodore Feldman, Khurram Nasir 2015 Baptist Health Medical Group

Sleep Duration Is Associated With Degree Of Insulin Resistance In A High Risk Population: The Baptist Employee Healthy Heart Study, Shozab Ali, Ebenezer Oni, Ehimen Aneni, Lara Roberson, Janisse Post, Gagandeep Nagi, Sameer Shaharyar, Omar Jamal, Rehan Malik, Muhammad Aziz, Adnan Younus, Beatriz Rosell, Henry Guzman, Ricardo Cury, Jonathan Fialkow, Arthur Agatston, Emir Veledar, Theodore Feldman, Khurram Nasir

Khurram Nasir

No abstract provided.


Relationship Of Insulin Resistance With Impaired Endothelial Function & Coronary Atherosclerosis Among High Risk Individuals Enrolled In A Web-Based Lifestyle Intervention Study: Baptist Employee Healthy Heart Study (Behhs), Ehimen Aneni, Ebenezer Oni, Lara Roberson, Janisse Post, Gagandeep Nagi, Sameer Shaharyar, Omar Jamal, Shozab Ali, Rehan Malik, Muhammad Aziz, Adnan Younus, Chen Ye, Beatriz Rosell, Henry Guzman, Ricardo Cury, Jonathan Fialkow, Arthur Agatston, Emir Veledar, Theodore Feldman, Khurram Nasir 2015 Baptist Health Medical Group

Relationship Of Insulin Resistance With Impaired Endothelial Function & Coronary Atherosclerosis Among High Risk Individuals Enrolled In A Web-Based Lifestyle Intervention Study: Baptist Employee Healthy Heart Study (Behhs), Ehimen Aneni, Ebenezer Oni, Lara Roberson, Janisse Post, Gagandeep Nagi, Sameer Shaharyar, Omar Jamal, Shozab Ali, Rehan Malik, Muhammad Aziz, Adnan Younus, Chen Ye, Beatriz Rosell, Henry Guzman, Ricardo Cury, Jonathan Fialkow, Arthur Agatston, Emir Veledar, Theodore Feldman, Khurram Nasir

Khurram Nasir

No abstract provided.


My Unlimited Potential: Multidimensional Workplace Life Style Modification Program Associated With Reduction In Cardiovascular Disease Risk Among Employees With Type 2 Diabetes, Sankalp Das, Maribeth Rouseff, Henry Guzman, Thinh Tran, Doris Brown, Joann Santiago-Charles, Teresa Ochoa, Joseph Mora, Cynthia Gilliam, Virginia Lehn, Angelica Ruiz, Ehimen Aneni, Oluseye Ogunmoroti, Lara Roberson, Emir Veledar, Janisse Post, Khurram Nasir 2015 Baptist Health Medical Group

My Unlimited Potential: Multidimensional Workplace Life Style Modification Program Associated With Reduction In Cardiovascular Disease Risk Among Employees With Type 2 Diabetes, Sankalp Das, Maribeth Rouseff, Henry Guzman, Thinh Tran, Doris Brown, Joann Santiago-Charles, Teresa Ochoa, Joseph Mora, Cynthia Gilliam, Virginia Lehn, Angelica Ruiz, Ehimen Aneni, Oluseye Ogunmoroti, Lara Roberson, Emir Veledar, Janisse Post, Khurram Nasir

Khurram Nasir

No abstract provided.


The Esoteric Roles Of Bcl-2 Family Proteins In Glucose Homeostasis And Cell Survival., Shona L. Pfeiffer, Jochen Prehn 2015 Royal College of Surgeons in Ireland

The Esoteric Roles Of Bcl-2 Family Proteins In Glucose Homeostasis And Cell Survival., Shona L. Pfeiffer, Jochen Prehn

Physiology and Medical Physics Articles

No abstract provided.


Prescribing Patterns Of Metformin In High-Risk Patients With Prediabetes, Daniel Stirling, Ifeanyi Onor, Daniel Sarpong, Kristi Isaac Rapp, Lori Crawford 2015 Xavier University of Louisiana

Prescribing Patterns Of Metformin In High-Risk Patients With Prediabetes, Daniel Stirling, Ifeanyi Onor, Daniel Sarpong, Kristi Isaac Rapp, Lori Crawford

Ifeanyi Onor, PharmD, BCPS

Aims: The primary objective of this study is to examine the rates of metformin prescribing in patients with prediabetes who are either < 60 years of age, have a BMI ≥35 kg/m2, or women with a history of gestational diabetes mellitus (GDM). Secondary objectives include: 1) examination of the time from diagnosis of prediabetes to the initiation of metformin and 2) if metformin initiation status and length of time correlates to the patient having any other additional diabetes mellitus (DM) risk factors.

Methods: This was a single center, retrospective cohort study. This study included all patients with prediabetes, defined as ...


Marginal Structural Models For The Estimation Of The Risk Of Diabetes Mellitus In The Presence Of Elevated Depressive Symptoms And Antidepressant Medication Use In The Women's Health Initiative Observational And Clinical Trial Cohorts, Christine Frisard, Xiangdong Gu, Brian Whitcomb, Yunsheng Ma, Penelope Pekow, Martha Zorn, Deidre M. Sepavich, Raji Balasubramanian 2015 University of Massachusetts Medical School

Marginal Structural Models For The Estimation Of The Risk Of Diabetes Mellitus In The Presence Of Elevated Depressive Symptoms And Antidepressant Medication Use In The Women's Health Initiative Observational And Clinical Trial Cohorts, Christine Frisard, Xiangdong Gu, Brian Whitcomb, Yunsheng Ma, Penelope Pekow, Martha Zorn, Deidre M. Sepavich, Raji Balasubramanian

Open Access Articles

BACKGROUND: We evaluate the combined effect of the presence of elevated depressive symptoms and antidepressant medication use with respect to risk of type 2 diabetes among approximately 120,000 women enrolled in the Women's Health Initiative (WHI), and compare several different statistical models appropriate for causal inference in non-randomized settings.

METHODS: Data were analyzed for 52,326 women in the Women's Health Initiative Clinical Trials (CT) Cohort and 68,169 women in the Observational Study (OS) Cohort after exclusions. We included follow-up to 2005, resulting in a median duration of 7.6 years of follow up after enrollment ...


Data From: The Cardiovascular Effects Of Adjunctive Metformin Therapy In Overweight/Obese Youth With Type 1 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial, Benjamin U. Nwosu, Louise S. Maranda, Karen Cullen, Lisa Greenman, Jody Fleshman, Nancy McShea, Bruce A. Barton, Mary M. Lee 2015 University of Massachusetts Medical School

Data From: The Cardiovascular Effects Of Adjunctive Metformin Therapy In Overweight/Obese Youth With Type 1 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial, Benjamin U. Nwosu, Louise S. Maranda, Karen Cullen, Lisa Greenman, Jody Fleshman, Nancy Mcshea, Bruce A. Barton, Mary M. Lee

Benjamin U. Nwosu

This dataset is the primary data source for a manuscript submitted for publication.

Manuscript abstract:

Context: The cardiovascular effect of adjunctive metformin therapy in overweight/obese youth with type 1 diabetes (T1D) is unknown.

Objective: To compare the effect of prolonged, adjunctive metformin vs. placebo therapy on markers of cardiovascular risk in overweight/obese youth with T1D based on differences in total cholesterol (TC)/ high-density lipoprotein (HDL) ratio, triglycerides (TG)/HDL ratio, Atherogenic Index of Plasma (AIP) log [TG/HDL] ratio, adiponectin/leptin ratio, and 25-hydroxyvitamin D [25(OH)D] concentration.

Hypothesis: Adjunctive metformin therapy will improve markers of cardiovascular ...


Data From: The Cardiovascular Effects Of Adjunctive Metformin Therapy In Overweight/Obese Youth With Type 1 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial, Benjamin U. Nwosu, Louise S. Maranda, Karen Cullen, Lisa Greenman, Jody Fleshman, Nancy McShea, Bruce A. Barton, Mary M. Lee 2015 University of Massachusetts Medical School

Data From: The Cardiovascular Effects Of Adjunctive Metformin Therapy In Overweight/Obese Youth With Type 1 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial, Benjamin U. Nwosu, Louise S. Maranda, Karen Cullen, Lisa Greenman, Jody Fleshman, Nancy Mcshea, Bruce A. Barton, Mary M. Lee

Benjamin U. Nwosu

This dataset is the primary data source for a manuscript submitted for publication.

Manuscript abstract:

Context: The cardiovascular effect of adjunctive metformin therapy in overweight/obese youth with type 1 diabetes (T1D) is unknown.

Objective: To compare the effect of prolonged, adjunctive metformin vs. placebo therapy on markers of cardiovascular risk in overweight/obese youth with T1D based on differences in total cholesterol (TC)/ high-density lipoprotein (HDL) ratio, triglycerides (TG)/HDL ratio, Atherogenic Index of Plasma (AIP) log [TG/HDL] ratio, adiponectin/leptin ratio, and 25-hydroxyvitamin D [25(OH)D] concentration.

Hypothesis: Adjunctive metformin therapy will improve markers of cardiovascular ...


Data From: The Cardiovascular Effects Of Adjunctive Metformin Therapy In Overweight/Obese Youth With Type 1 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial, Benjamin U. Nwosu, Louise S. Maranda, Karen Cullen, Lisa Greenman, Jody Fleshman, Nancy McShea, Bruce A. Barton, Mary M. Lee 2015 University of Massachusetts Medical School

Data From: The Cardiovascular Effects Of Adjunctive Metformin Therapy In Overweight/Obese Youth With Type 1 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial, Benjamin U. Nwosu, Louise S. Maranda, Karen Cullen, Lisa Greenman, Jody Fleshman, Nancy Mcshea, Bruce A. Barton, Mary M. Lee

Pediatric Research Data

This dataset is the primary data source for a manuscript submitted for publication.

Manuscript abstract:

Context: The cardiovascular effect of adjunctive metformin therapy in overweight/obese youth with type 1 diabetes (T1D) is unknown.

Objective: To compare the effect of prolonged, adjunctive metformin vs. placebo therapy on markers of cardiovascular risk in overweight/obese youth with T1D based on differences in total cholesterol (TC)/ high-density lipoprotein (HDL) ratio, triglycerides (TG)/HDL ratio, Atherogenic Index of Plasma (AIP) log [TG/HDL] ratio, adiponectin/leptin ratio, and 25-hydroxyvitamin D [25(OH)D] concentration.

Hypothesis: Adjunctive metformin therapy will improve markers of cardiovascular ...


Bh3-Only Protein Bmf Is Required For The Maintenance Of Glucose Homeostasis In An In Vivo Model Of Hnf1Α-Mody Diabetes, Shona L. Pfeiffer, Luise Halang, Heiko Düssmann, Maria M. Byrne, Jochen Prehn 2015 Royal College of Surgeons in Ireland

Bh3-Only Protein Bmf Is Required For The Maintenance Of Glucose Homeostasis In An In Vivo Model Of Hnf1Α-Mody Diabetes, Shona L. Pfeiffer, Luise Halang, Heiko Düssmann, Maria M. Byrne, Jochen Prehn

Physiology and Medical Physics Articles

Heterozygous loss-of-function mutations in the hepatocyte nuclear factor 1α (HNF-1α) gene can lead to diminished amounts of functional HNF-1α, resulting in the onset of a particularly severe form of maturity-onset diabetes of the young (MODY). We have previously shown that induction of a dominant-negative mutant of HNF-1α (DNHNF-1α) results in the activation of the bioenergetic stress sensor AMP-activated protein kinase (AMPK), preceding the onset of apoptosis and the induction of pro-apoptotic Bcl-2 homology domain-3-only protein Bmf (Bcl-2-modifying factor) as a mediator of DNHNF-1α-induced apoptosis. Through the knockout of bmf in a transgenic mouse ...


New-Onset Diabetes Mellitus With Exposure To Ledipasvir And Sofosbuvir., Resmi Premji, Nira Roopnarinesingh, Nazia Qazi, Eric S. Nylen 2015 George Washington University

New-Onset Diabetes Mellitus With Exposure To Ledipasvir And Sofosbuvir., Resmi Premji, Nira Roopnarinesingh, Nazia Qazi, Eric S. Nylen

Medicine Faculty Publications

The combination therapy of ledipasvir/sofosbuvir was approved by the Food and Drug Administration in 2014 for the treatment of chronic hepatitis C. Although hyperglycemia is not well known to occur with its use, we present 2 cases of new-onset diabetes mellitus and a review of the literature suggesting an adverse event association. In the first patient with HIV, we postulate that ledipasvir/sofosbuvir increased the levels of tenofovir and thereby potentiated hyperglycemia. In the second case of a patient with prediabetes, ledipasvir/sofosbuvir appeared to increase insulin resistance. A literature review further supported an association of hyperglycemia and the ...


Enhanced Fitness And Renal Function In Type 2 Diabetes., Eric S. Nylen, S. M. Gandhi, Raya E. Kheirbek, Peter Kokkinos 2015 George Washington University

Enhanced Fitness And Renal Function In Type 2 Diabetes., Eric S. Nylen, S. M. Gandhi, Raya E. Kheirbek, Peter Kokkinos

Medicine Faculty Publications

Aims

To investigate the renal effects of fitness in people with diabetes with mild renal dysfunction.

Methods

The effect of a 12-week exercise programme on estimated GFR in 128 people with diabetes was evaluated.

Results

All cardiometabolic variables improved after 12 weeks of supervised exercise. Although there was a modest 3.9% increase in estimated GFR from baseline in the 128 people who completed the study, those with baseline chronic kidney disease stages 2 and 3 were found to have significant (6 and 12%, respectively; p < 0.01) improvements in post-exercise estimated GFR. Moreover, 42% of the people with chronic kidney disease stage 3 improved to chronic kidney disease stage 2 after the intervention.

Conclusion

Short-term exercise improves renal function in those with more moderate baseline chronic kidney ...


A Randomized, Double-Blind, Placebo-Controlled Trial Of Adjunctive Metformin Therapy In Overweight/Obese Youth With Type 1 Diabetes, Benjamin U. Nwosu, Louise Maranda, Karen Cullen, Lisa Greenman, Jody Fleshman, Nancy McShea, Bruce A. Barton, Mary M. Lee 2015 University of Massachusetts Medical School

A Randomized, Double-Blind, Placebo-Controlled Trial Of Adjunctive Metformin Therapy In Overweight/Obese Youth With Type 1 Diabetes, Benjamin U. Nwosu, Louise Maranda, Karen Cullen, Lisa Greenman, Jody Fleshman, Nancy Mcshea, Bruce A. Barton, Mary M. Lee

Mary M. Lee

CONTEXT: Insulin resistance has been proposed as one of the causes of poor glycemic control in overweight/obese youth with type 1 diabetes (T1D). However, the role of adjunctive metformin, an insulin sensitizer, on glycemic control in these patients is unclear. OBJECTIVE: To compare the effect of metformin vs. placebo on hemoglobin A1c (HbA1c), total daily dose (TDD) of insulin, and other parameters in overweight/obese youth with T1D. HYPOTHESIS: Adjunctive metformin therapy will improve glycemic control in overweight/obese youth with T1D. DESIGN, SETTING, AND PARTICIPANTS: A 9-mo randomized, double-blind, placebo controlled trial of metformin and placebo in 28 ...


A Randomized, Double-Blind, Placebo-Controlled Trial Of Adjunctive Metformin Therapy In Overweight/Obese Youth With Type 1 Diabetes, Benjamin U. Nwosu, Louise Maranda, Karen Cullen, Lisa Greenman, Jody Fleshman, Nancy McShea, Bruce A. Barton, Mary M. Lee 2015 University of Massachusetts Medical School

A Randomized, Double-Blind, Placebo-Controlled Trial Of Adjunctive Metformin Therapy In Overweight/Obese Youth With Type 1 Diabetes, Benjamin U. Nwosu, Louise Maranda, Karen Cullen, Lisa Greenman, Jody Fleshman, Nancy Mcshea, Bruce A. Barton, Mary M. Lee

Benjamin U. Nwosu

CONTEXT: Insulin resistance has been proposed as one of the causes of poor glycemic control in overweight/obese youth with type 1 diabetes (T1D). However, the role of adjunctive metformin, an insulin sensitizer, on glycemic control in these patients is unclear. OBJECTIVE: To compare the effect of metformin vs. placebo on hemoglobin A1c (HbA1c), total daily dose (TDD) of insulin, and other parameters in overweight/obese youth with T1D. HYPOTHESIS: Adjunctive metformin therapy will improve glycemic control in overweight/obese youth with T1D. DESIGN, SETTING, AND PARTICIPANTS: A 9-mo randomized, double-blind, placebo controlled trial of metformin and placebo in 28 ...


A Randomized, Double-Blind, Placebo-Controlled Trial Of Adjunctive Metformin Therapy In Overweight/Obese Youth With Type 1 Diabetes, Benjamin U. Nwosu, Louise Maranda, Karen Cullen, Lisa Greenman, Jody Fleshman, Nancy McShea, Bruce A. Barton, Mary M. Lee 2015 University of Massachusetts Medical School

A Randomized, Double-Blind, Placebo-Controlled Trial Of Adjunctive Metformin Therapy In Overweight/Obese Youth With Type 1 Diabetes, Benjamin U. Nwosu, Louise Maranda, Karen Cullen, Lisa Greenman, Jody Fleshman, Nancy Mcshea, Bruce A. Barton, Mary M. Lee

Endocrinology/Diabetes

CONTEXT: Insulin resistance has been proposed as one of the causes of poor glycemic control in overweight/obese youth with type 1 diabetes (T1D). However, the role of adjunctive metformin, an insulin sensitizer, on glycemic control in these patients is unclear.

OBJECTIVE: To compare the effect of metformin vs. placebo on hemoglobin A1c (HbA1c), total daily dose (TDD) of insulin, and other parameters in overweight/obese youth with T1D.

HYPOTHESIS: Adjunctive metformin therapy will improve glycemic control in overweight/obese youth with T1D.

DESIGN, SETTING, AND PARTICIPANTS: A 9-mo randomized, double-blind, placebo controlled trial of metformin and placebo in 28 ...


Noncommunicable Diseases And Injuries: Action Needed In South Asia Too, Ali Khan Khuwaja, Riaz Qureshi, Zafar Fatmi 2015 Aga Khan University

Noncommunicable Diseases And Injuries: Action Needed In South Asia Too, Ali Khan Khuwaja, Riaz Qureshi, Zafar Fatmi

Zafar Fatmi

No abstract provided.


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