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Male Urogenital Diseases Commons

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Does Treatment With Onabotulinumtoxina Improve The Quality Of Life In Patients With Urinary Incontinence Not Adequately Controlled With Anticholinergics?, Victoria J. Kopec 2015 Philadelphia College of Osteopathic Medicine

Does Treatment With Onabotulinumtoxina Improve The Quality Of Life In Patients With Urinary Incontinence Not Adequately Controlled With Anticholinergics?, Victoria J. Kopec

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not treatment with onabotulinumtoxinA improves the quality of life in patients with urinary incontinence not adequately controlled with anticholinergics.

STUDY DESIGN: Review of three English language, randomized controlled trials published in 2013.

DATA SOURCES: Randomized, double-blind, controlled clinical trials comparing onabotulinumtoxinA intradetrusor injections with saline placebo. All articles were found using PubMed.

OUTCOMES MEASURED: Each of the three trials assessed the patient’s quality of life after treatment with onabotulinumtoxinA using the following assessment tools: Incontinence Quality of Life Questionnaire (I-QOL), Modified Overactive Bladder Patient Satisfaction with ...


Is Proton Beam Therapy More Effective Than Intensity-Modulated Radiotherapy In Prostate Cancer Treatment?, Daniel Zelefsky 2015 Touro College

Is Proton Beam Therapy More Effective Than Intensity-Modulated Radiotherapy In Prostate Cancer Treatment?, Daniel Zelefsky

The Science Journal of the Lander College of Arts and Sciences

Prostate cancer is the most common form of cancer found in American males. Breaking technological advances in prostate cancer treatment continue to develop to help fight this disease, one such is proton beam therapy. Proton beam therapy is theorized to spare even more healthy tissue than photon radiotherapy because it delivers a majority of its radiation during the Bragg peak. Since this technology is substantially costlier than any other form of radiation therapy, physicians are assessing its effectiveness and determining if it is worth the cost. Currently, there is no significant difference seen in patient quality of life between recipients ...


Prostate Cancer Microparticles As A Next Generation Screening Tool For Prostate Cancer, Khurram M. Siddiqui 2014 The University of Western Ontario

Prostate Cancer Microparticles As A Next Generation Screening Tool For Prostate Cancer, Khurram M. Siddiqui

Electronic Thesis and Dissertation Repository

Currently available screening tests for prostate cancer (PCa) are neither very sensitive nor specific. Microparticles (MP) are submicron tumor cell fragments released by PCa cells into the circulation and offer a possible means of sampling the tumor. We evaluated the utility of a MP blood test using nanoscale flow cytometry to distinguish patients with PCa from patients with benign prostatic hyperplasia (BPH). We used monoclonal antibodies against prostate specific membrane antigen, gastrin releasing peptide receptor and ghrelin peptide ligand.

We found higher but statistically insignificant, PSMA and Ghrelin dual +ve MP counts in the BPH group. Our results show that ...


Transitional Cell Carcinomas Of The Urinary Bladder. A Histopathological Study, Z. Ahmed, S. Muzaffer, M. Khan, N. Kayani, Shahid Pervez, A. S. Husseini, S H. Hasan 2014 Aga Khan University

Transitional Cell Carcinomas Of The Urinary Bladder. A Histopathological Study, Z. Ahmed, S. Muzaffer, M. Khan, N. Kayani, Shahid Pervez, A. S. Husseini, S H. Hasan

Shahid Pervez

Objective: To determine the histological grading and muscle invasion in Transitional Cell Carcinomas of the Urinary Bladder; and to evaluate whether any correlation exists between tumour grade and muscle invasion. Method: A Retrospective study of all consecutive cases of Transitional Cell Carcinomas of the Urinary Bladder diagnosed at Aga Khan University Hospital between 1st Jan 1997 and 31st Dec 2000. Results: This study included 495 cases of Transitional Cell Carcinoma of the Urinary Bladder. M: F ratio was 4:1. Ages of patients ranged from 30 years to 87 years. Mean age in males was 59.1 years and in ...


Llw-3-6 And Celecoxib Impacts Growth In Prostate Cancer Cells And Subcellular Localization Of Cox-2, Tokunbo Yerokun, Leyte L. Winfield 2014 Department of Biology, Spelman College

Llw-3-6 And Celecoxib Impacts Growth In Prostate Cancer Cells And Subcellular Localization Of Cox-2, Tokunbo Yerokun, Leyte L. Winfield

Spelman College Faculty Publications

The proliferation in human prostate carcinomas, PC3 and MDA-PCa-2b, was analyzed for cells treated with LLW-3-6 and celecoxib in the presence and absence of sulfasalazine. LLW-3-6 was more potent than celecoxib at mediating a dose-dependent reduction of viable PC3 cells. Co-treatment with a non-lethal dose of sulfasalazine diminished the potency of both drugs in this cell line. The effects of the drugs in MDA-PCa-2b cells were less significant than those observed in the PC3 cells. Localization of COX-2 in LLW-3-6- and CBX-treated PC3 cells is consistent with protein aggregation known for cells responding to stress stimuli. To complement this, an ...


Case Report On Renal Failure Reversal In Lambda Chain Multiple Myeloma With Bortezomib And Dexamethasone, Bhanu K. Patibandla, Akshita Narra, Ahmad A. Alwassia, Anthony Bartley, Gurprataap S. Sandhu, James Rooney, Robert M. Black 2014 University of Massachusetts Medical School Worcester

Case Report On Renal Failure Reversal In Lambda Chain Multiple Myeloma With Bortezomib And Dexamethasone, Bhanu K. Patibandla, Akshita Narra, Ahmad A. Alwassia, Anthony Bartley, Gurprataap S. Sandhu, James Rooney, Robert M. Black

Open Access Articles

Renal failure (RF) reversal in multiple myeloma (MM) is associated with an improved prognosis. Light chain myeloma, serum creatinine (SCr) > 4 mg/dL, extensive proteinuria, early infections, and certain renal biopsy findings are associated with lower rates of RF reversal. Our patient is a 67-year-old female with multiple poor prognostic factors for RF reversal who demonstrated a rapid renal response with bortezomib and dexamethasone (BD) regimen. She presented initially with altered mental status. On exam, she appeared lethargic and dehydrated and had generalized tenderness. She had been taking ibuprofen as needed for pain for a few weeks. Labs showed a ...


-174g/C Polymorphism In The Interleukin-6 Promoter Is Differently Associated With Prostate Cancer Incidence Depending On Race, Sanjay Mandal, Fisseha Abebe, Jaideep Chaudhary 2014 Clark Atlanta University

-174g/C Polymorphism In The Interleukin-6 Promoter Is Differently Associated With Prostate Cancer Incidence Depending On Race, Sanjay Mandal, Fisseha Abebe, Jaideep Chaudhary

Clark Atlanta University Faculty Publications

Interleukin-6 (IL-6), a pro-inflammatory cytokine, is involved in prostate cancer progression, including androgen independence. Serum IL-6 levels also correlate with prostate tumor burden, prostate-specific antigen levels and metastasis. Since circulating cytokine levels vary considerably inter-individually, such variation could be linked to genetic factors, including genetic polymorphism. The -174G>C/rs1800795 polymorphism in the IL-6 promoter is functionally relevant in terms of transcriptional regulation and disease association. We investigated a possible association of the -174G/C polymorphism with prostate cancer. Since significant racial disparities exist in prostate cancer incidence, we also investigated this association between the -174G/C polymorphism and prostate ...


Camalexin-Induced Apoptosis In Prostate Cancer Cells Involves Alterations Of Expression And Activity Of Lysosomal Protease Cathepsin D, Basil Smith, Diandra Randle, Roman Mezencev, LeeShawn Thomas, Cimona Hinton, Valerie Odero-Marah 2014 Center for Cancer Research and Therapeutic Development, Department of Biological Sciences, Clark Atlanta University

Camalexin-Induced Apoptosis In Prostate Cancer Cells Involves Alterations Of Expression And Activity Of Lysosomal Protease Cathepsin D, Basil Smith, Diandra Randle, Roman Mezencev, Leeshawn Thomas, Cimona Hinton, Valerie Odero-Marah

Clark Atlanta University Faculty Publications

Camalexin, the phytoalexin produced in the model plant Arabidopsis thaliana, possesses antiproliferative and cancer chemopreventive effects. We have demonstrated that the cytostatic/cytotoxic effects of camalexin on several prostate cancer (PCa) cells are due to oxidative stress. Lysosomes are vulnerable organelles to Reactive Oxygen Species (ROS)-induced injuries, with the potential to initiate and or facilitate apoptosis subsequent to release of proteases such as cathepsin D (CD) into the cytosol. We therefore hypothesized that camalexin reduces cell viability in PCa cells via alterations in expression and activity of CD. Cell viability was evaluated by MTS cell proliferation assay in LNCaP ...


Effect Of Pegloticase On Renal Function In Patients With Chronic Kidney Disease: A Post Hoc Subgroup Analysis Of 2 Randomized, Placebo-Controlled, Phase 3 Clinical Trials, Robert A. Yood, Faith D. Ottery, William Irish, Marsha Wolfson 2014 Reliant Medical Group

Effect Of Pegloticase On Renal Function In Patients With Chronic Kidney Disease: A Post Hoc Subgroup Analysis Of 2 Randomized, Placebo-Controlled, Phase 3 Clinical Trials, Robert A. Yood, Faith D. Ottery, William Irish, Marsha Wolfson

Meyers Primary Care Institute Publications

BACKGROUND: Pegloticase is approved in the US for treatment of refractory chronic gout. Since chronic kidney disease (CKD) is common in these patients, we conducted a post-hoc analysis of 2 replicate phase 3 trials and the subsequent open-label extension study to determine the effects of pegloticase on renal function in patients with CKD stages 3 and 4, as well as the effects of renal dysfunction on pegloticase efficacy and safety.

FINDINGS: Patients with renal insufficiency were randomized to pegloticase 8 mg every 2 weeks (n = 42), pegloticase 8 mg every 4 weeks (n = 41), or placebo (n = 20) for 6 ...


Is Magnetic Stimulation Effective In Treating Urinary Incontinence?, Sydney Brandtomies 2014 Philadelphia College of Osteopathic Medicine

Is Magnetic Stimulation Effective In Treating Urinary Incontinence?, Sydney Brandtomies

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not Magnetic stimulation is an effective treatment for women with urinary incontinence.

STUDY DESIGN: Review of three published, randomized controlled trials (two double-blind and one single blinded), all English language.

DATA SOURCES: The three randomized controlled trials that were used for this review were found using PubMed and EBSCOhost. Articles were selected based on relevance and that the outcomes of the studies mattered to patients.

OUTCOME(S) MEASURED: Improvement of urinary incontinence measured by pad-tests and questionnaires.

RESULTS: The results of the But study suggest that magnetic ...


Does Male Circumcision Prevent Herpes Simplex Virus Type 2 In Sexually Active Males Aged 18-50?, Mary K. Macon 2014 Philadelphia College of Osteopathic Medicine

Does Male Circumcision Prevent Herpes Simplex Virus Type 2 In Sexually Active Males Aged 18-50?, Mary K. Macon

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not male circumcision prevents herpes simplex virus type 2 (“HSV-2”) in sexually active males aged 18- 50.

STUDY DESIGN: Review of three English language primary studies published in 2009 and 2012.

DATA SOURCES: Three randomized control trials analyzing the intervention of circumcision to prevent HSV-2 in sexually active males found using Medline and PubMed.

OUTCOMES MEASURED: The main clinical outcome in all studies measured the incidence of HSV-2 defined as a sexually transmitted infection with symptoms of visible genital ulceration. The outcomes were measure by patient self-report ...


Is Famciclovir Superior To Valacyclovir As A Treatment For Recurrent Gential Herpes In Reducing Outbreak Duration And Frequency?, Snow Feng 2014 Philadelphia College of Osteopathic Medicine

Is Famciclovir Superior To Valacyclovir As A Treatment For Recurrent Gential Herpes In Reducing Outbreak Duration And Frequency?, Snow Feng

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine “Is famciclovir superior to valacyclovir as a treatment for recurrent genital herpes in reducing outbreak duration and frequency?”

STUDY DESIGN: This review is based on three double-blind, randomized controlled trials (RCTs) published in 2006, 2008, and 2009. The studies compared the efficacy and safety of famciclovir (FCV) vs. valacyclovir (VCV) in the treatment of genital herpes.

DATA SOURCES: All articles used were published in English, in peer-reviewed journals, and found using PubMed.

OUTCOMES MEASURED: The effectiveness of famciclovir and valacyclovir was evaluated based on the proportion of patients with ...


Natural History Of Untreated Prostate Specific Antigen Radiorecurrent Prostate Cancer In Men With Favorable Prognostic Indicators, Andrew Renshaw 2014 Baptist Hospital of Miami

Natural History Of Untreated Prostate Specific Antigen Radiorecurrent Prostate Cancer In Men With Favorable Prognostic Indicators, Andrew Renshaw

All Publications

No abstract provided.


The Effects Of Age, Ethnicity, Sexual Dysfunction, Urinary Incontinence, Masculinity, And Relationship With The Partner On The Quality Of Life Of Men With Prostate Cancer, Suha Ballout 2013 Florida International University

The Effects Of Age, Ethnicity, Sexual Dysfunction, Urinary Incontinence, Masculinity, And Relationship With The Partner On The Quality Of Life Of Men With Prostate Cancer, Suha Ballout

FIU Electronic Theses and Dissertations

Prostate cancer, the leading cause of cancer in men, has positive survival rates and constitutes a challenge to men with its side effects. Studies have addressed the bivaritate relationships between prostate cancer treatment side effects masculinity, partner relationship, and quality of life (QOL). However, few studies have highlighted the relationships among prostate cancer treatment side effects (i.e., sexual dysfunction, urinary incontinence), masculinity, and relationship with the partner together on QOL in men. Most studies were conducted with predominately Caucasian sample of men. Miami is a unique multiethnic setting that hosts Cuban, Columbian, Venezuelan, Haitian, other Latin American and Caribbean ...


The Predictive Value Of Renal Ultrasound Of Vesicoureteral Reflux After First Urinary Tract Infection In Neonates And Infants 0-24 Months, Richard J. Mazzaccaro MD, Michael J. Weiss MPH 2013 Lehigh Valley Health Network

The Predictive Value Of Renal Ultrasound Of Vesicoureteral Reflux After First Urinary Tract Infection In Neonates And Infants 0-24 Months, Richard J. Mazzaccaro Md, Michael J. Weiss Mph

Department of Pediatrics

No abstract provided.


Impact Of Mirabegron Extended-Release On The Treatment Of Overactive Bladder With Urge Urinary Incontinence, Urgency, And Frequency, Raymond Lee, Mitchell H. Bamberger, Pamela Ellsworth 2013 University of Massachusetts Medical School

Impact Of Mirabegron Extended-Release On The Treatment Of Overactive Bladder With Urge Urinary Incontinence, Urgency, And Frequency, Raymond Lee, Mitchell H. Bamberger, Pamela Ellsworth

University of Massachusetts Medical School Faculty Publications

Overactive bladder is a highly prevalent disorder with a significant impact on quality of life. Antimuscarinic agents are commonly used, but persistence is limited due to unsatisfactory efficacy and/or tolerability. Mirabegron is the first beta-3 adrenoceptor agonist approved for the treatment of overactive bladder syndrome. This paper reviews the pharmacology, mechanism of action, efficacy, and safety of mirabegron. A PubMed search of all English articles pertaining to mirabegron was performed. An alternative to antimuscarinics, mirabegron has a unique mechanism, improves overactive bladder symptoms and quality of life, and has limited adverse effects and few contraindications.


The Uncertainty Of The Egfr, Tony Badrick, Peter Turner 2013 Bond University

The Uncertainty Of The Egfr, Tony Badrick, Peter Turner

Tony Badrick

The estimated glomerular filtration rate (eGFR) is a parameter derived from the serum creatinine, patient age and gender and is used to ascertain renal function. It is subject to variation because of the analytical error of the creatinine measurement and biological variation. The widespread use of the eGFR to classify renal disease has led to the identification of more patients with marginal chronic kidney disease but because of the uncertainty of the eGFR it has also led to over-diagnosis of some kidney disease. There is a well described age relation with eGFR.The uncertainty of the eGFR at the critical ...


Immunization Against A Saccharide Epitope Accelerates Clearance Of Experimental Gonococcal Infection, Sunita Gulati, Bo Zheng, George W. Reed, Xiaohong Su, Andrew D. Cox, Frank St. Michael, Jacek Stupak, Lisa A. Lewis, Sanjay Ram, Peter A. Rice 2013 University of Massachusetts Medical School

Immunization Against A Saccharide Epitope Accelerates Clearance Of Experimental Gonococcal Infection, Sunita Gulati, Bo Zheng, George W. Reed, Xiaohong Su, Andrew D. Cox, Frank St. Michael, Jacek Stupak, Lisa A. Lewis, Sanjay Ram, Peter A. Rice

University of Massachusetts Medical School Faculty Publications

The emergence of ceftriaxone-resistant strains of Neisseria gonorrhoeae may herald an era of untreatable gonorrhea. Vaccines against this infection are urgently needed. The 2C7 epitope is a conserved oligosaccharide (OS) structure, a part of lipooligosaccharide (LOS) on N gonorrhoeae. The epitope is expressed by 94% of gonococci that reside in the human genital tract (in vivo) and by 95% of first passaged isolates. Absence of the 2C7 epitope shortens the time of gonococcal carriage in a mouse model of genital infection. To circumvent the limitations of saccharide immunogens in producing long lived immune responses, previously we developed a peptide mimic ...


The Chronic Kidney Disease Controversy: How Expanding Definitions Care Unnecessarily Labelling Many People As Diseased, Ray Moynihan, Richard Glassock, Jenny A. Doust 2013 Bond University

The Chronic Kidney Disease Controversy: How Expanding Definitions Care Unnecessarily Labelling Many People As Diseased, Ray Moynihan, Richard Glassock, Jenny A. Doust

Jenny Doust

Extract: In 2002 the United States Kidney Foundation launched a novel framework for defining and classifying chronic kidney disease. The framework was widely embraced because it imposed order in a chaotic landscape characterised by a variety of names, including renal insufficiency, renal impairment, and renal failure. It has had an appreciable effect on clinical care worldwide through guidelines, pay for performance measures, and sparked debate on the merits of screening programmes. However, it has also generated considerable controversy. We examine the rationale for the framework, the varying responses and controversies it has provoked, and provide advice for clinicians who are ...


The Chronic Kidney Disease Controversy: How Expanding Definitions Care Unnecessarily Labelling Many People As Diseased, Ray Moynihan, Richard Glassock, Jenny A. Doust 2013 Bond University

The Chronic Kidney Disease Controversy: How Expanding Definitions Care Unnecessarily Labelling Many People As Diseased, Ray Moynihan, Richard Glassock, Jenny A. Doust

Ray Moynihan

Extract: In 2002 the United States Kidney Foundation launched a novel framework for defining and classifying chronic kidney disease. The framework was widely embraced because it imposed order in a chaotic landscape characterised by a variety of names, including renal insufficiency, renal impairment, and renal failure. It has had an appreciable effect on clinical care worldwide through guidelines, pay for performance measures, and sparked debate on the merits of screening programmes. However, it has also generated considerable controversy. We examine the rationale for the framework, the varying responses and controversies it has provoked, and provide advice for clinicians who are ...


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