Albany State University, Georgia
Division of Infectious Diseases, Department of Medicine, University of Louisville School of Medicine, Louisville, KY, USA and Washington Health Institute, Washington, D.C., USA
Thomas Jefferson University
The University of Western Ontario
University of San Francisco
The Population Affected By The Syndemic Of Covid-19 And Poverty Is More Likely To Be Hospitalized With Sars-Cov-2 Pneumonia,
2021
University of Louisville
The Population Affected By The Syndemic Of Covid-19 And Poverty Is More Likely To Be Hospitalized With Sars-Cov-2 Pneumonia, Julio A. Ramirez, Stephen P. Furmanek, Meredith Cahill, Stephen S. Hanson, Ruth Carrico, Forest W. Arnold
The University of Louisville Journal of Respiratory Infections
Background
Lockdown measures to control COVID-19 have exacerbated the poverty epidemic. We hypothesized that the synergistic interaction of COVID-19 and poverty epidemics favors the development of more severe forms of COVID-19 in the population living in poverty. To test this hypothesis, we assessed whether an ecological association exists between the geographic distribution of hospitalized patients with SARS-CoV-2 pneumonia and markers of poverty in the city of Louisville, KY.
Methods
Using the geomasked home addresses of hospitalized patients with SARS-CoV-2 pneumonia in the city of Louisville, a kernel density heatmap was created. Kuldorff’s spatial scan statistic was used to calculate ...
Non-Selective Primary Human Tumor Cell Line Generation From Surgical Resections To Be Paired With Flash Frozen And Paraffin Embedded Tissue: Advancements In Democratizing Translational Research Materials To Rural Institutions,
2021
Marshall University
Non-Selective Primary Human Tumor Cell Line Generation From Surgical Resections To Be Paired With Flash Frozen And Paraffin Embedded Tissue: Advancements In Democratizing Translational Research Materials To Rural Institutions, Jennifer Hawkins, Rebecca Russell, Logan M. Lawrence, Amrita Valluri, Jessica Wellman, Krista Denning
Marshall Journal of Medicine
Translational cancer research relies on the availability of human patient tissue demonstrating the specific disease process under investigation. Biobanks of human tissue have historically been and remain to date the primary access point for cancer research samples. Biorepositories routinely supply researchers with varying sample types for use in biomedical studies; most commonly formalin-fixed and paraffin-embedded (FFPE) tissue, or fresh snap-frozen tissue. In conjunction with preserved tissue samples, viable tumor cell lines derived from patient tissue have emerged to be a new gold standard in cancer research particularly in drug discovery and functional prognostic assays. Tissue banks providing these samples are ...
Streptococcus Anginosus Lung Infection And Empyema: A Case Report And Review Of The Literature,
2021
University of Louisville
Streptococcus Anginosus Lung Infection And Empyema: A Case Report And Review Of The Literature, Nishita Tripathi, Kuldeep Ghosh, Anupama Raghuram
The University of Louisville Journal of Respiratory Infections
Streptococcus milleri group (SMG) also referred to as the Streptococcus anginosus group. These are Gram-positive, variable hemolysis, catalase negative, microaerophilic, non-motile facultative anaerobes which have been known to cause abscesses in humans. We report a case of empyema caused by Streptococcus anginosus in a patient with an unresolved pneumonia for over a month. In early October 2018, the patient presented to an emergency room with the complaints of shortness of air, productive cough, chills, subjective fever and weight loss for 4 weeks. A chest X-ray revealed a left lower lobe pneumonia. He was treated with 250 mg of azithromycin for ...
Invasive Pneumococcal Serotype 3 Disease Despite Pneumococcal Polysaccharide Vaccine-23,
2021
University of Louisville, Louisville, KY
Invasive Pneumococcal Serotype 3 Disease Despite Pneumococcal Polysaccharide Vaccine-23, B. Frank Parker Jr, Forest W. Arnold
The University of Louisville Journal of Respiratory Infections
Pneumococcal disease has a high global morbidity and mortality. We report a case of a 63-year old female with a history of vaccination with pneumococcal polysaccharide vaccine-23 (PPSV-23) who was transferred to a tertiary care facility with fever and seizures due to an unknown etiology. The diagnosis of invasive pneumococcal disease (IPD) was based the identification of Streptococcus pneumoniae in the blood (culture; serogroup 3) and cerebrospinal fluid (antigen), and the finding of purulence under pressure at craniotomy. The pneumococcal vaccine should provide protection from IPD. The findings reported here display that IPD can overcome immunity proffered by the pneumococcal ...
A Multi-Institutional Partnership Catalyzing The Commercialization Of Medical Devices And Biotechnology Products.,
2021
University of Massachusetts Medical School
A Multi-Institutional Partnership Catalyzing The Commercialization Of Medical Devices And Biotechnology Products., Nathaniel Hafer, Bryan Buchholz, Denise Dunlap, Brennan Fournier, Scott Latham, Mary Ann Picard, Steven Tello, Laura L. Gibson, Craig M. Lilly, David D. Mcmanus
COVID-19 Publications by UMMS Authors
The commercialization of medical devices and biotechnology products is characterized by high failure rates and long development lead times particularly among start-up enterprises. To increase the success rate of these high-risk ventures, the University of Massachusetts Lowell (UML) and University of Massachusetts Medical School (UMMS) partnered to create key academic support centers with programs to accelerate entrepreneurship and innovation in this industry. In 2008, UML and UMMS founded the Massachusetts Medical Device Development Center (M2D2), which is a business and technology incubator that provides business planning, product prototyping, laboratory services, access to clinical testing, and ecosystem networking to medical device ...
To Preprint Or Not To Preprint,
2021
University of Louisville
To Preprint Or Not To Preprint, Forest W. Arnold, Kimberley A. Buckner, Alex Glynn, Jessica Petrey, Jose Bordon
The University of Louisville Journal of Respiratory Infections
No abstract provided.
Combinatorial Use Of Both Epigenetic And Non-Epigenetic Mechanisms To Efficiently Reactivate Hiv Latency,
2021
Kampala International University-Western Campus
Combinatorial Use Of Both Epigenetic And Non-Epigenetic Mechanisms To Efficiently Reactivate Hiv Latency, Joseph Hokello, Adhikarimayum Lakhikumar Sharma, Mudit Tyagi
Center for Translational Medicine Faculty Papers
The persistence of latent HIV provirus pools in different resting CD4+ cell subsets remains the greatest obstacle in the current efforts to treat and cure HIV infection. Recent efforts to purge out latently infected memory CD4+ T-cells using latency-reversing agents have failed in clinical trials. This review discusses the epigenetic and non-epigenetic mechanisms of HIV latency control, major limitations of the current approaches of using latency-reversing agents to reactivate HIV latency in resting CD4+ T-cells, and potential solutions to these limitations.
Assessing Pre-Exposure Prophylaxis Screening And Need Among Men Who Have Sex With Men And Transgender Persons Of Color: A Mixed Methods Case Study Of The Impact Dmv Demonstration Project,
2021
The George Washington University School of Medicine and Health Sciences
Assessing Pre-Exposure Prophylaxis Screening And Need Among Men Who Have Sex With Men And Transgender Persons Of Color: A Mixed Methods Case Study Of The Impact Dmv Demonstration Project, Brittany C. Wilbourn
Doctor of Philosophy in Translational Health Sciences Dissertations
Men who have sex with men (MSM) and transgender persons of color experience disproportionate, multi-level HIV risks. Pre-exposure prophylaxis (PrEP) is an evidence-based HIV prevention strategy; however, access to PrEP has been limited among this population. PrEP demonstration projects that target MSM and transgender persons and test the implementation of PrEP in real-world settings are underway. However, PrEP demonstration projects specific to MSM and transgender persons of color are limited and most demonstration projects do not consider the impact of the implementation process or organization contextual characteristics on PrEP outcomes. The Improve Measurable Participation and Access to Care and Treatment ...
Diagnosis And Management Of Adolescents With Polycystic Ovary Syndrome In Primary Care: A Mixed Method Study To Explore Provider Behaviors And Barriers And Facilitators To Practice,
2021
George Washington University
Diagnosis And Management Of Adolescents With Polycystic Ovary Syndrome In Primary Care: A Mixed Method Study To Explore Provider Behaviors And Barriers And Facilitators To Practice, J. Leocadia Conlon
Doctor of Philosophy in Translational Health Sciences Dissertations
Background: Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder in women of reproductive age, associated with complications of metabolic, reproductive, and psychological health. Adolescence is an optimal time for early identification of PCOS in order to mitigate long-term health risks. Pediatric primary care providers (pedPCPs) are the first-line for early identification and coordination of longterm comprehensive management. Limited information exists to describe how PCOS is addressed in primary care and if adolescent-specific guidelines are applied.
Objectives: Describe practice behaviors of pedPCPs in the diagnosis and management of PCOS, and identify barriers and facilitators to inform future interventions to optimize ...
The Precaution Adoption Process Model In Describing Emergency Action Plan Adoption,
2021
West Virginia University
The Precaution Adoption Process Model In Describing Emergency Action Plan Adoption, Samantha E. Scarneo-Miller, Douglas J. Casa, Shuang Yin, Timothy E. Moore, Yuki Murata, Johna Kay Register-Mihalik, Lindsay J. Distefano
Internet Journal of Allied Health Sciences and Practice
Purpose: The purpose of this study was to identify the ability of the Precaution Adoption Process Model (PAPM) to classify athletic trainers (ATs) and athletic directors (ADs) readiness to act with regards to adopting an emergency action plan (EAP), and describe factors influencing PAPM stages. Method: We used a cross-sectional questionnaire design to evaluate readiness to act for developing an EAP among ATs and ADs working in United States high schools. The PAPM is a participant-driven model to identify someone’s readiness to act or change and has seven stages: Unaware, Unengaged, Undecided, Decided not to Act, Decided to Act ...
A New Chapter In The Life Of The Journal,
2021
University of Louisville
A New Chapter In The Life Of The Journal, Julio A. Ramirez
The University of Louisville Journal of Respiratory Infections
No abstract provided.
International Respiratory Infections Society Covid Research Conversations: Podcast 3 With Dr. Antoni Torres,
2021
University of Louisville
International Respiratory Infections Society Covid Research Conversations: Podcast 3 With Dr. Antoni Torres, Julio A. Ramirez, Antoni Torres
The University of Louisville Journal of Respiratory Infections
Section(s) Topics
1–4 Introductions
5 “Spanish” influenza
6–9 Dr. Torres’ personal thoughts and experiences
10 COVID-19 hospitalizations in Barcelona
11 A threatening phone call
12–13 Origin of the CIBERESUCICOVID project
14 Baseline characteristics
15 Bloodwork at hospital admission; ICU admission vs. day 3
16 Treatments
17 Complications
18 Outcomes related to interventions
19 Viral RNA load in plasma associated with critical illness and dysregulated response
20 Follow-up with health care workers
21 Medical education
22 Conclusions
23–26 Interleukin 6
27–29 Ventilatory approach
30–33 Post-COVID syndrome
34–38 Impact on health care workers
39 ...
A Transition Of Uljri Leadership,
2021
University of Louisville
A Transition Of Uljri Leadership, Forest W. Arnold, Jose Bordon
The University of Louisville Journal of Respiratory Infections
No abstract provided.
Challenges In Defining Long Covid: Striking Differences Across Literature, Electronic Health Records, And Patient-Reported Information,
2021
University of Colorado
Challenges In Defining Long Covid: Striking Differences Across Literature, Electronic Health Records, And Patient-Reported Information, Halie M. Rando, Feifan Liu, Melissa A. Haendel
UMass Center for Clinical and Translational Science Supported Publications
Since late 2019, the novel coronavirus SARS-CoV-2 has introduced a wide array of health challenges globally. In addition to a complex acute presentation that can affect multiple organ systems, increasing evidence points to long-term sequelae being common and impactful. The worldwide scientific community is forging ahead to characterize a wide range of outcomes associated with SARS-CoV-2 infection; however the underlying assumptions in these studies have varied so widely that the resulting data are difficult to compare. Formal definitions are needed in order to design robust and consistent studies of Long COVID that consistently capture variation in long-term outcomes. Even the ...
International Respiratory Infections Society Covid Research Conversations: Podcast 2 With Dr. Michael S. Niederman And Dr. Edward J. Schenck,
2021
University of Louisville
International Respiratory Infections Society Covid Research Conversations: Podcast 2 With Dr. Michael S. Niederman And Dr. Edward J. Schenck, Julio A. Ramirez, Michael S. Niederman, Edward J. Schenck
The University of Louisville Journal of Respiratory Infections
Section(s) Topics
1–4 Introductions
5 COVID-19 in New York City
6–7 Telemedicine, long-term sequelae
8 Development of a multi-disciplinary ICU team
9–10 Treatment of ARDS, COVID-19 pathogenesis
11–12 Prioritizing treatment at research
13 Challenges in tracing the natural history of severe COVID-19
14–15 Experience with mechanically ventilated patients; non-pulmonary organ failure
16–17 Mapping COVID-19 trajectories by SOFA score
18–20 Findings: additive organ dysfunction, improving vs. worsening trajectory
21 ARDS therapeutic approaches
22 Clinical trials involving Cornell
23–25 Lessons learned: patient care, research, education, caring for critical care workers
26–30 2021 ...
Defining Early And Late Clinical Outcomes In Patients With Sars-Cov-2 Pneumonia,
2021
University of Louisville
Defining Early And Late Clinical Outcomes In Patients With Sars-Cov-2 Pneumonia, Julio A. Ramirez, Jose Bordon, Rodrigo Cavallazzi, Stephen P. Furmanek, Jiapeng Huang, Timothy L. Wiemken, Forest W. Arnold
The University of Louisville Journal of Respiratory Infections
No abstract provided.
H1n1 Influenza Virus (Swine Flu): A Comprehensive Insight Into Escalating Catch-22 Scenarios,
2021
University of Sargodha, Sargodha
H1n1 Influenza Virus (Swine Flu): A Comprehensive Insight Into Escalating Catch-22 Scenarios, Muhammad Shahzaib, Ehsan Ul Haq
The University of Louisville Journal of Respiratory Infections
Introduction: Viruses have always been a major cause of various disastrous pandemics in mankind’s history. H1N1 became a threat when its original strain was first discovered back in the swine flu pandemic of 2009. It became highly catastrophic on a large scale because none of the therapeutic interventions and methodologies that were already present at the time were effective against the virus.
Methods: A vast amount of literature and research is available regarding H1N1 influenza from different reputable sources online. The data was gathered following the contrasting and relative situations of 1918 as well as the 2009 pandemic in ...
Adapting A Traumatic Brain Injury Goals-Of-Care Decision Aid For Critically Ill Patients To Intracerebral Hemorrhage And Hemispheric Acute Ischemic Stroke,
2021
University of Massachusetts Medical School
Adapting A Traumatic Brain Injury Goals-Of-Care Decision Aid For Critically Ill Patients To Intracerebral Hemorrhage And Hemispheric Acute Ischemic Stroke, Kelsey Goostrey, Christopher Lee, Kelsey Jones, Thomas Quinn, Jesse Moskowitz, Jolanta J. Pach, Andrea K. Knies, Lori Shutter, Robert J. Goldberg, Kathleen M. Mazor, David Y. Hwang, Susanne Muehlschlegel
UMass Center for Clinical and Translational Science Supported Publications
Objectives: Families in the neurologic ICU urgently request goals-of-care decision support and shared decision-making tools. We recently developed a goals-of-care decision aid for surrogates of critically ill traumatic brain injury patients using a systematic development process adherent to the International Patient Decision Aid Standards. To widen its applicability, we adapted this decision aid to critically ill patients with intracerebral hemorrhage and large hemispheric acute ischemic stroke.
Design: Prospective observational study.
Setting: Two academic neurologic ICUs.
Subjects: Twenty family members of patients in the neurologic ICU were recruited from July 2018 to October 2018.
Interventions: None.
Measurements and Main Results: We ...
International Respiratory Infections Society Covid Research Conversations: Podcast 1 With Dr. Francesco Blasi,
2021
Center of Excellence for Research in Infectious Diseases, Division of Infectious Diseases, University of Louisville, Louisville, KY
International Respiratory Infections Society Covid Research Conversations: Podcast 1 With Dr. Francesco Blasi, Julio A. Ramirez Md, Francesco Blasi Md, Phd
The University of Louisville Journal of Respiratory Infections
Section(s) Topics
1–2 Introductions
3 Foundations of best practice
4 COVID-19 as stimulus for innovation
5 Adapting and evolving therapeutic approach
6 Age and comorbidities as risk factors
7 Over-capacity ICU
8 Adapting the ER for COVID-19
9 Training personnel for COVID-19
10 Psychological support, healthcare heroes, and COVID fatigue
11 Increased oxygen requirement
12–13 Milan’s multi-disciplinary unit
14 Standardizing respiratory support measures
15 Nutrition, sedation, and life support
16 CPAP successes and failures
17 Prone and lateral positioning of patients on CPAP
18 Different COVID-19 phenotypes?
19 Thromboembolism risk score, age, and comorbidities
20 Cardiorespiratory ...
An Update On The Leading Covid-19 Vaccines,
2021
Center of Excellence for Research in Infectious Diseases, Division of Infectious Diseases, Department of Medicine, School of Medicine, University of Louisville, Louisville, KY, USA
An Update On The Leading Covid-19 Vaccines, Ahmed A. Eladely, Javaria Anwer Mbbs, Ashwini Gotimukul Mbbs, Manish Kc Mbbs, Jessica Petrey Msls, Alex Glynn Ma, Ruth M. Carrico Phd, Dnp, Julio A. Ramirez Md
The University of Louisville Journal of Respiratory Infections
We reviewed the COVID-19 vaccines that reached phase III of clinical development. For each of the 10 vaccines identified, we described the technology used for vaccine development, the available data from phase III clinical trials, data on vaccine safety, and the role of new SARS-CoV-2 variants on vaccine efficacy.
