Marshall University
Philadelphia College of Osteopathic Medicine
Thomas Jefferson University Hospitals, Philadelphia, PA, USA
Liberty University
The Graduate Center, City University of New York
University of Pennsylvania
Cedarville University
CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY, FACULTY OF PHARMACY, DEPARTMENT OF CLINICAL LABORATORY AND FOOD HYGIENE, BUCHAREST, ROMANIA
TÜBİTAK
Targeting Brd4 In The Treatment Of Pleural Fibrosis,
2023
University of Texas at Tyler
Targeting Brd4 In The Treatment Of Pleural Fibrosis, Joy Adewumi
Biotechnology Theses
Pleural fibrosis (PF) is a respiratory disorder that refers to the thickening and scarring of the pleura. Currently, there is a lack of pharmaceutic treatment options for PF. Pleural mesothelial to mesenchymal transition (MesoMT) is a critical process that contributes to the development of PF. Bromodomain-containing protein 4 (BRD4), a transcriptional and epigenetic regulator, has recently been implicated in a wide range of lung injuries. However, whether BRD4 is involved in regulating MesoMT and the development of PF remains unclear and was explored in this study. Primary human pleural mesothelial cells (HPMCs) were used to test the role of BRD4 …
Effects Of Interleukin-22 (Il-22) On Necroptosis, Inflammatory Responses, And Metabolism Of Mycobacterium Tuberculosis Stimulated Type 2 Diabetes Mellitus Mouse Macrophages,
2023
University of Texas Health Center at Tyler
Effects Of Interleukin-22 (Il-22) On Necroptosis, Inflammatory Responses, And Metabolism Of Mycobacterium Tuberculosis Stimulated Type 2 Diabetes Mellitus Mouse Macrophages, Bismark Owusu-Afriyie
Biotechnology Theses
Mycobacterium tuberculosis (Mtb) infects one-third of the world’s population and causes nearly 1.3 million deaths per year. Limited information is available about the immune responses during Mtb infection in type 2 diabetic hosts. Our laboratory developed an experimentally induced type 2 diabetes (T2DM) model in wild-type C57BL/6 mice and found that IL-22 and type 3 innate lymphoid cells (ILC3s) reduce inflammation and mortality of Mtb-infected T2DM mice. Our laboratory also found that Mtb-infected alveolar macrophages (AMs) from T2DM mice undergo necroptosis compared to Mtb-infected AMs of non-T2DM mice. In the current study, we determined whether …
Intouch Week Of Ju Ne 5, 2023,
2023
Touro College and University System
Intouch Week Of Ju Ne 5, 2023, New York Medical College
InTouch
- NYMC Set to Host Golf Tournament and Reception
- SOM Health and Justice Elective Gets a Hand from 16-year-old CEO
Extrinsic Allergic Alveolitis: A Systematic Review Of Hla-Dr In Pigeon Breeder’S Disease,
2023
University of Central Florida; Lake Erie College of Osteopathic Medicine, Bradenton
Extrinsic Allergic Alveolitis: A Systematic Review Of Hla-Dr In Pigeon Breeder’S Disease, Dylan Thibaut, Ryan A. Witcher, Anitha Kunnath, James Toldi
Advances in Clinical Medical Research and Healthcare Delivery
Abstract
Introduction: Pigeon Breeder’s Pneumonitis (PBP) results due to a complex pathophysiology that includes exposure to avian antigens. Susceptibility has been linked to human leukocyte antigen (HLA) class II, though consensus has not been reached. The goal of this systematic review is to further elucidate the association between PBP and HLA-DR subtypes.
Methods: Databases utilized included PubMed, Google Scholar, ScienceDirect, and Cochrane Library. Inclusion required a minimum of three studies in English presenting HLA-DR alleles of PBP and control subgroups. Exclusion was due to insufficient data or non-feasible control groups. Forest plots were created for HLA-DR subtypes’ association …
Irf7 And Unc93b1 Variants In An Infant With Recurrent Herpes Simplex Virus Infection.,
2023
Children's Mercy Kansas City
Irf7 And Unc93b1 Variants In An Infant With Recurrent Herpes Simplex Virus Infection., Megan H. Tucker, Wei Yu, Heather Menden, Sheng Xia, Carl F. Schreck, Margaret Gibson, Daniel A. Louiselle, T Pastinen, Nikita Raje, Venkatesh Sampath
Manuscripts, Articles, Book Chapters and Other Papers
Neonatal herpes simplex virus (HSV) infection is a devastating disease with substantial morbidity and mortality. The genetic basis of susceptibility to HSV in neonates remains undefined. We evaluated a male infant with neonatal skin/eye/mouth (SEM) HSV-1 disease, who had complete recovery after acyclovir but developed HSV-1 encephalitis at 1 year of age. An immune workup showed an anergic PBMC cytokine response to TLR3 stimulation but no other TLRs. Exome sequencing identified rare missense variants in IFN-regulatory factor 7 (IRF7) and UNC-93 homolog B1 (UNC93B1). PBMC single-cell RNA-Seq done during childhood revealed decreased expression of several innate immune genes and a …
Metals And Metal Complexes In Diseases With A Focus On Covid-19: Facts And Opinions,
2023
The John Paul II Catholic University of Lublin
Metals And Metal Complexes In Diseases With A Focus On Covid-19: Facts And Opinions, Agnieszka Ścibior, Manuel Aureliano, Alvin A. Holder, Juan Llopis
Chemistry & Biochemistry Faculty Publications
In the present Special Issue on “Metals and Metal Complexes in Diseases with a Focus on COVID-19: Facts and Opinions”, an attempt has been made to include reports updating our knowledge of elements considered to be potential candidates for therapeutic applications and certain metal-containing species, which are extensively being examined towards their potential biomedical use due to their specific physicochemical properties. The Special Issue compiles data on the role of metals in COVID-19 and focuses on other illnesses and biological processes that affect metal metabolism. It consists of eight manuscripts, including five review articles and three original research papers (Figure …
Dean's Update, June 2023,
2023
New York Medical College
Dean's Update, June 2023, Edward C. Halperin
SOM Dean's Research Newsletter
No abstract provided.
X-Linked Variations In Shroom4 Are Implicated In Congenital Anomalies Of The Urinary Tract And The Anorectal, Cardiovascular And Central Nervous Systems,
2023
Children's Mercy Hospital
X-Linked Variations In Shroom4 Are Implicated In Congenital Anomalies Of The Urinary Tract And The Anorectal, Cardiovascular And Central Nervous Systems, Caroline M. Kolvenbach, Tim Felger, Luca Schierbaum, Isabelle Thiffault, T Pastinen, Maria Szczepańska, Marcin Zaniew, Piotr Adamczyk, Allan Bayat, Öznur Yilmaz, Tobias T. Lindenberg, Holger Thiele, Friedhelm Hildebrandt, Katrin Hinderhofer, Ute Moog, Alina C Hilger, Bonnie Sullivan, Lauren E. Bartik, Piotr Gnyś, Phillip Grote, Benjamin Odermatt, Heiko M. Reutter, Gabriel C. Dworschak
Manuscripts, Articles, Book Chapters and Other Papers
Background: SHROOM4 is thought to play an important role in cytoskeletal modification and development of the early nervous system. Previously, single-nucleotide variants (SNVs) or copy number variations (CNVs) in SHROOM4 have been associated with the neurodevelopmental disorder Stocco dos Santos syndrome, but not with congenital anomalies of the urinary tract and the visceral or the cardiovascular system.
Methods: Here, exome sequencing and CNV analyses besides expression studies in zebrafish and mouse and knockdown (KD) experiments using a splice blocking morpholino in zebrafish were performed to study the role of SHROOM4 during embryonic development.
Results: In this study, we identified putative …
Neural Correlates Of Comorbidity Of Anxiety Disorders And Eating Disorders,
2023
Portland State University
Neural Correlates Of Comorbidity Of Anxiety Disorders And Eating Disorders, Karsen Coelho
University Honors Theses
The presence of eating disorder and anxiety disorder comorbidity has raised the question of whether or not there is a causal relationship between them. Previous studies have found that this comorbidity has been present in various patients with anxiety disorders and eating disorders, going further to try and determine which diagnosis came first (Swinbourne et al., 2012). By conducting a literature review, studies were examined to determine neurobiological regions impacted by both disorders. Prefrontal cortex abnormalities are consistent among both disorders, contributing to differences in behavior and reward systems. With the irregular structure and activation of the amygdala, emotion and …
Development And Validation Of Mechatronic Systems For Image-Guided Needle Interventions And Point-Of-Care Breast Cancer Screening With Ultrasound (2d And 3d) And Positron Emission Mammography,
2023
Western University
Development And Validation Of Mechatronic Systems For Image-Guided Needle Interventions And Point-Of-Care Breast Cancer Screening With Ultrasound (2d And 3d) And Positron Emission Mammography, Claire Ks Park
Electronic Thesis and Dissertation Repository
The successful intervention of breast cancer relies on effective early detection and definitive diagnosis. While conventional screening mammography has substantially reduced breast cancer-related mortalities, substantial challenges persist in women with dense breasts. Additionally, complex interrelated risk factors and healthcare disparities contribute to breast cancer-related inequities, which restrict accessibility, impose cost constraints, and reduce inclusivity to high-quality healthcare. These limitations predominantly stem from the inadequate sensitivity and clinical utility of currently available approaches in increased-risk populations, including those with dense breasts, underserved and vulnerable populations.
This PhD dissertation aims to describe the development and validation of alternative, cost-effective, robust, and high-resolution …
Functional Impact Of Ethyl-Β-D-Glucuronide On Mycobacterium Tuberculosis Stimulated Lung Macrophages,
2023
University of Texas at Tyler
Functional Impact Of Ethyl-Β-D-Glucuronide On Mycobacterium Tuberculosis Stimulated Lung Macrophages, Charles Inaku
Biotechnology Theses
Chronic alcohol abuse has been shown to alter immune defense mechanisms in humans and mice which makes the host susceptible to infections, including Mycobacterium tuberculosis (Mtb) infection. However, limited information is available on the mechanisms involved in alcohol-mediated host immune system dysfunction.
In this study, we determined the effects of ethyl-β-d-glucuronide (EtG), an alcohol-derived metabolite, on immune response of mice lung macrophages. We measured cytokine and chemokine production by gamma-irradiated mtb (γ-mtb) stimulated mice lung macrophages in the presence or absence of EtG. We also determined the effect of EtG on the metabolic state of γ-mtb stimulated mice lung macrophages. …
Intouch Week Of May 29, 2023,
2023
Touro College and University System
Intouch Week Of May 29, 2023, New York Medical College
InTouch
- NYMC Celebrates the Class of 2023 at 164th Commencement Exercises
- Department of Surgery Hosts 20th Annual Louis R.M. DelGuercio Distinguished Visiting Professorship and Research Day
- NYMC Hosted the 12th Annual Paul K. Woolf, M.D., Pediatric Trainee Research Day
- Bench-to-Bedside Seminar Series: Fetal Biophysical Profile, Development of an In-utero Apgar Score
- Study Addresses Disparities in Women and Diverse Racial and Ethnic Groups in Radiation Oncology
- Five Tips to Stay Safe During Tick Season from NYMC's Lyme Disease Expert
- NYMC's Blood Drives Donate More Than 500 Units This Academic Year
The Intensity Of Free Radical Processes And Chaperone Activity In The Saliva Of Patients With Type 2 Diabetes,
2023
Department of Biology, Voronezh State Medical University named after N.N. Burdenko, Voronezh, Russian Federation
The Intensity Of Free Radical Processes And Chaperone Activity In The Saliva Of Patients With Type 2 Diabetes, Anna A. Cheprasova, Sergey S. Popov, Alexander N. Pashkov, Aleksei N. Verevkin, Valentina O. Mittova, Konstantin K. Shulgin
BioMedicine
Introduction: Saliva is a clinically informative biological fluid that contains many biomarkers, allowing multiple analyses to be performed. Aim: The objectives of this study were the assessment of the serum and saliva levels of biochemical parameters and intensity of free radical processes in T2DM patients and the identification of the correlation between certain criteria. Methods: This case-control study included 40 T2DM patients, which were compared with 40 healthy individuals. The levels of glucose, cholesterol triglycerides, total protein, diene conjugates, and chaperone activity were measured using the spectrophotometric method. The concentration of 8-oxo-2'-deoxyguanosine was assessed by competitive enzyme-linked immunosorbent assay. Results: …
Radial Arterial Waves For Chemotherapy- And Radiotherapy-Related Myocardial Damage Identification In Patients With Breast Cancer,
2023
Department of Chinese Medicine, Changhua Christian Hospital, Changhua, Taiwan
Radial Arterial Waves For Chemotherapy- And Radiotherapy-Related Myocardial Damage Identification In Patients With Breast Cancer, Chia-Ying Lee, Daniela Yunchin Yen, Mark C. Hou, Ying-Ling Chen, Rong-Jen Shiau
BioMedicine
Introduction
Chemotherapy and radiation therapy for breast cancer cause side effects, such as cardiovascular changes, which can be monitored with echocardiography. However, more convenient methods are always encouraged. Radial arterial waves that are used to detect cardiovascular changes can be used to assist in confirming cardiovascular changes.
Aim
This retrospective study aimed to analyze the frequency and time domains of the radial artery pulse wave in patients with breast cancer to understand its effectiveness in identifying cardiovascular changes.
Methods
Patients with breast cancer were screened from the pulse examination records in
Changhua Christian Hospital and divided into the treatment and …
Toxicological Evaluation Of A Polyherbal Formulation On Testicular Function And Gonadal Histomorphology In Exposed Wistar Rats,
2023
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Federal University Oye-Ekiti, PMB 373, Oye-Ekiti, Nigeria
Toxicological Evaluation Of A Polyherbal Formulation On Testicular Function And Gonadal Histomorphology In Exposed Wistar Rats, Godswill James Udom, Uduak Peter Ise, Omoirri Moses Aziakpono, Ayodeji Aturamu, Mba Ogbonnaya, Israel Kevin Umana, Jude Efiom Okokon
BioMedicine
Introduction: Dr Iguedo Goko Cleanser® is a herbal formulation (HF) widely marketed in southern Nigeria and purported to be very efficacious for the management of various diseases including giardiasis, toilet infections, hypertension, diabetes, ulcer, impotence, low libido, low sperm count amongst others. Medicinal plants reportedly produce an array of adverse reactions capable of inducing harmful conditions, including death. Aim: This study evaluated the subchronic toxicity concern of HF on testicular function and gonadal histoarchitecture in Wistar rats. Methods: Thirty Wistar rats of both sexes were randomly divided into six groups (5/group) and were orally administered HF for 60 days. The …
Effects Of Anti-Retroviral Therapy On Baseline Serum Interleukin-18 Levels In Hiv-I Infected Patients Relative To Viral Suppression And Cd4+ Gain: A Prospective Pilot Study,
2023
Department of Medical Microbiology, Ahmadu Bello University Teaching Hospital, Zaria,Nigeria
Effects Of Anti-Retroviral Therapy On Baseline Serum Interleukin-18 Levels In Hiv-I Infected Patients Relative To Viral Suppression And Cd4+ Gain: A Prospective Pilot Study, Olayemi Balogun, Bukhari Isah Shuaib, Abdulrasheed Usman, Aminu Abba Yusuf, Bolanle O. P. Musa, Obiako O. Reginald, Aliyu Ahmadu Babadoko
BioMedicine
Background: In HIV infection, dysregulation of cytokines, including interleukin 18 (IL-18), has been linked to poor clinical outcomes in studies mainly conducted in resource-rich countries. This phenomenon has not been well-studied in resource-limited settings where outcomes could be confounded by exposure to endemic infections and genetic factors.
Objectives: Therefore, the influence of immunological and virological status of HIV-infected, antiretroviral therapy (ART)-naïve patients on serum IL-18 levels at baseline (pretreatment) and 24 weeks following initiation of combination ART (cART24) in a resource-limited setting was investigated. Methods Using the cross-sectional and longitudinal mixed method design, a total of Forty-four (44) newly diagnosed …
Metformin Induces Autophagy Of Cisplatin-Resistant Human Gastric Cancer Cells In Addition To Apoptosis,
2023
Division of Pharmacy, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan
Metformin Induces Autophagy Of Cisplatin-Resistant Human Gastric Cancer Cells In Addition To Apoptosis, Chih-Wun Fang, Jai-Sing Yang, Jo-Hua Chiang, Po-Chuen Shieh, Fuu-Jen Tsai, Chia-Wen Tsai, Wen-Shin Chang
BioMedicine
Metformin has been used to treat cases of type 2 diabetes mellitus, and mounting studies have shown that metformin can act alone or in synergy with other anticancer agents to achieve anti-cancer efficacies on various types of tumors. However, the role of metformin in either inducing autophagy and cisplatin-resistance of human gastric cancer (GC) cells has never been examined. The study has established a cisplatin-resistant GC cell line and investigated the effects of metformin on inducing autophagy on it. The results demonstrated that treatment with metformin can concentration-dependently suppress the cell viability and cell confluence of cisplatin-resistant GC cells, while …
Precision Medicine Advancements In Glioblastoma: A Systematic Review,
2023
Department of Biotechnology, Maulana Abul Kalam Azad University of Technology, West Bengal
Precision Medicine Advancements In Glioblastoma: A Systematic Review, Karan Iyer, Shubham Saini, Suman Bhadra, Sohini Kulavi, Jaya Bandyopadhyay
BioMedicine
Background. Glioblastoma multiforme, commonly known as GBM or glioblastoma is a grade IV astrocytoma. Brain tumors are difficult to treat and lead to poor prognosis and survival in patients. Gliomas are categorized into four different grades among which GBM is the worst grade primary brain tumor with a survival of less than a year. The genomic heterogeneity of the brain tumor results in different profiles for patients diagnosed with glioblastoma. Precision medicine focuses on this specific tumor type and suggests specialized treatment for better prognosis and overall survival (OS). Purpose. With the recent advancements in Genome-Wide Studies (GWS) and various …
Starvation Sensing By Mycobacterial Rela/Spot Homologue Through Constitutive Surveillance Of Translation,
2023
Thomas Jefferson University
Starvation Sensing By Mycobacterial Rela/Spot Homologue Through Constitutive Surveillance Of Translation, Yunlong Li, Soneya Majumdar, Ryan Treen, Manjuli R. Sharma, Jamie Corro, Howard B. Gamper, Swati R. Manjari, Jerome Prusa, Nilesh K. Banavali, Christina L. Stallings, Ya-Ming Hou, Rajendra K. Agrawal, Anil K. Ojha
Department of Biochemistry and Molecular Biology Faculty Papers
The stringent response, which leads to persistence of nutrient-starved mycobacteria, is induced by activation of the RelA/SpoT homolog (Rsh) upon entry of a deacylated-tRNA in a translating ribosome. However, the mechanism by which Rsh identifies such ribosomes in vivo remains unclear. Here, we show that conditions inducing ribosome hibernation result in loss of intracellular Rsh in a Clp protease-dependent manner. This loss is also observed in nonstarved cells using mutations in Rsh that block its interaction with the ribosome, indicating that Rsh association with the ribosome is important for Rsh stability. The cryo-EM structure of the Rsh-bound 70S ribosome in …
Membrane Compression By Synaptic Vesicle Exocytosis Triggers Ultrafast Endocytosis,
2023
Thomas Jefferson University
Membrane Compression By Synaptic Vesicle Exocytosis Triggers Ultrafast Endocytosis, Tyler H Ogunmowo, Haoyuan Jing, Sumana Raychaudhuri, Grant F Kusick, Yuuta Imoto, Shuo Li, Kie Itoh, Ye Ma, Haani Jafri, Matthew B. Dalva, Edwin R Chapman, Taekjip Ha, Shigeki Watanabe, Jian Liu
Department of Neuroscience Faculty Papers
Compensatory endocytosis keeps the membrane surface area of secretory cells constant following exocytosis. At chemical synapses, clathrin-independent ultrafast endocytosis maintains such homeostasis. This endocytic pathway is temporally and spatially coupled to exocytosis; it initiates within 50 ms at the region immediately next to the active zone where vesicles fuse. However, the coupling mechanism is unknown. Here, we demonstrate that filamentous actin is organized as a ring, surrounding the active zone at mouse hippocampal synapses. Assuming the membrane area conservation is due to this actin ring, our theoretical model suggests that flattening of fused vesicles exerts lateral compression in the plasma …
