Chronic Stressors, Obesity Pathogenesis, And The Moderating Effect Of Internalized Weight Stigma; A Quantitative, Illinois Study, 2025 National Louis University
Chronic Stressors, Obesity Pathogenesis, And The Moderating Effect Of Internalized Weight Stigma; A Quantitative, Illinois Study, Karyn Byrne
Dissertations
The obesity epidemic is a ‘wicked’ problem with a complex web of determinants and outcomes. While generally higher for minoritized populations, prevalence rates manifest in surprising, nonlinear patterns. There is no consensus regarding treatment protocols or mitigation efforts, except that current efforts remain largely ineffective. Much research evidence that a profusion of determinants of health support obesity pathogenesis through various physiological processes and mechanisms, including the allostatic load, mitochondria functioning, the gut microbiome, and epigenetics. Intervening to support markers of the allostatic load (immunity, inflammation, and metabolic health) may provide a more effective treatment outcomes than traditional approaches, which tend …
Development, Validation, And Diagnostic Performance Of A Novel Radiomic Model For Predicting Prostate Cancer Recurrence, 2024 University of Nebraska Medical Center
Development, Validation, And Diagnostic Performance Of A Novel Radiomic Model For Predicting Prostate Cancer Recurrence, Linda M. Huynh
Theses & Dissertations
Multi-parametric magnetic resonance imaging (MP-MRI)-derived radiomics have been shown to capture sub-visual patterns for the quantitative characterization of prostate cancer (PC) phenotypes. The present dissertation seeks to develop, evaluate, and compare the performance of an MRI-derived radiomic model for the prediction of PC recurrence following definitive treatment with radical prostatectomy (RP).
MP-MRI was obtained from 339 patients who had a minimum of 2 years follow-up following RP at three institutions. The prostate was manually delineated as the region of interest and 924 radiomic features were extracted. All features were evaluated for stability via intraclass correlation coefficient (ICC) and image normalization …
Molecular Mechanisms Of Opioid Use Disorder In Human Brain Models, 2024 The Texas Medical Center Library
Molecular Mechanisms Of Opioid Use Disorder In Human Brain Models, Emily Mendez
Dissertations & Theses (Open Access)
Opioid use disorder (OUD) is a national and global public health crisis with no end in sight. While studies from animal models hint at widespread epigenetic and transcriptomic alterations of opioid drugs, the molecular consequences of long-term exposure to opioid drugs in human brain is still unclear, and human-centered translational models are necessary to discern the human cell type-specific effects of OUD.
Using postmortem brain Brodmann area 9 (BA9) from the UTHealth Brain Collection for Research on Psychiatric Disorders, I identified angiogenic gene networks perturbed in the RNA and protein of OUD subjects, as well as downregulation of many neuron-correlated …
Examining The Effects Of Menstrual Cycle Phase And Hormonal Contraceptive Use On Women's Sleep, 2024 University of Arkansas, Fayetteville
Examining The Effects Of Menstrual Cycle Phase And Hormonal Contraceptive Use On Women's Sleep, Charles Ethan Coombs
Psychological Science Undergraduate Honors Theses
Women overrepresent men for sub-optimal sleep, a consequence of hormone fluctuation in the menstrual cycle affecting sleep regulatory pathways. While research has examined the prevalence of sub-optimal sleep through cycle phases, little research has examined how hormonal contraceptives (HC’s) could similarly affect women’s sleep, while also neglecting to utilize subjective sleep measures. In this study, we examine subjective sleep quality among naturally cycling (NC) women, women using different HC types, and between active and inactive phase pill users by subjecting 463 women to a subjective sleep battery. We hypothesized that HC users would report more sub-optimal sleep than NC women. …
Intouch Week Of March 11, 2024, 2024 Touro College and University System
Intouch Week Of March 11, 2024, New York Medical College
InTouch
- Dr. Kenneth Knapp Named Chair of Department of Public Health
- Dr. Mitchell Cairo Secures $2.6M FDA Grant for Infant CMV Infection Research
- Department of Radiation Medicine Enrolls First Patient in Nation in Prostate Cancer Clinical Trial
- NYMC and Regeneron Debut Neighborhood Science Seminar Series
- NYMC Annual Days of Giving Set for March 26 and 27
- LCME Element of the Week
- Department Spotlight: The Office of Academic Excellence Elevates Student Achievement
- Dr.P.H. Candidate Advocates for Long Term Care Through the Media
Balancing The Medical, Psychiatric, And Ethical Considerations In The Inpatient Treatment Of Extreme Anorexia Nervosa: A Case Report, 2024 University of South Dakota, Sanford School of Medicine
Balancing The Medical, Psychiatric, And Ethical Considerations In The Inpatient Treatment Of Extreme Anorexia Nervosa: A Case Report, Carter A. Schulz, Carolyn A. Kennedy
Aesculapius Journal (Health Sciences & Medicine)
Introduction: Anorexia nervosa (AN) is a psychiatric illness characterized by restricted energy intake, intense fear of gaining weight, and a disturbance in body image. A 2011 meta-analysis estimated the mortality rate for anorexia nervosa to be over 5 times that of the general population, with one-fifth of deaths in AN patients being due to suicide. Treating this disease is notoriously difficult, and treatment is complicated by these patients’ characteristically poor insight.
Case summary: Here we present the case of a 37 year old woman who visited the ED with complaints of nausea and weakness; she was admitted due to hypoglycemia, …
The Symptoms And Management Of Children With Attention-Deficit/Hyperactivity Disorder During Covid-19 Pandemic At The Child And Adolescent Psychiatry Clinic, King Chulalongkorn Memorial Hospital, 2024 Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
The Symptoms And Management Of Children With Attention-Deficit/Hyperactivity Disorder During Covid-19 Pandemic At The Child And Adolescent Psychiatry Clinic, King Chulalongkorn Memorial Hospital, Nuttorn Pityaratstian
Chulalongkorn Medical Journal
Background: The coronavirus disease 2019 (COVID-19) pandemic has caused abrupt changes in almost everybody’s life, particularly children. Children and adolescents with attention-deficit hyperactivity disorder (ADHD) have difficulties in many aspects in lives and may have worsening of the symptoms during the pandemic.
Objectives: This cross-sectional descriptive study aimed to investigate the changes of the ADHD symptoms and managements of children with ADHD during the first lockdown and after-lockdown period.
Methods: Parent-reported questionnaires i.e. the Swanson, Nolan, and Pelham Rating Scale-IV (SNAP-IV) and a demographic questionnaire, were applied to collect data from 109 children with ADHD aged between 4 -18 years …
Detection Of Pathogenic Leptospira Spp. By Rpa-Nalfia Targeting Lipl32 Gene, 2024 Chulalongkorn University
Detection Of Pathogenic Leptospira Spp. By Rpa-Nalfia Targeting Lipl32 Gene, Nattachai Srisawat
Chulalongkorn Medical Journal
Background: Lack of available sensitive point-of-care tests is one of the key challenges limiting the early point-of-care diagnosis of leptospirosis.Previously, a Recombinase Polymerase Amplification (RPA) and clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 12a (CRISPR/Cas12a) lipL32 detection platform with high sensitivity and specificity was developed. However, its turnaround time is between one and two hours, and two reactions are required.
Objective: To develop the RPA in combination with a nucleic acid lateral flow immunoassay (NALFIA) detection platform to reduce the turnaround time and make it a one-step reaction.
Methods: RPA combined with nucleic acid lateral flow immunoassay (NALFIA) detection …
Effects Of Fine Particulate Matter On Hospital Admission Due To Stroke In A Business City Of Thailand, 2024 Chulalongkorn University
Effects Of Fine Particulate Matter On Hospital Admission Due To Stroke In A Business City Of Thailand, Piyanee Kasiravat
Chulalongkorn Medical Journal
Background: About 99.0% of global population was living in the area where air pollutant levels exceed World Health Organization Standard. Particulate matter whose diameter is equal to or less than 2.5 microns (PM2.5), is an important risk factor for chronic diseases including chronic respiratory diseases, heart diseases and lung cancer. However, the association between PM2.5 and cerebrovascular event is still controversial, especially in Asian populations.
Objective: To assess the association between PM2.5 and hospital admissions due to stroke.
Methods: A retrospective study was conducted using air monitoring and health data during 2017 - 2019 in Hatyai, a business city in …
Mandibular Plane To Hyoid In Lateral Cephalometry As A Predictive Parameter For Severity Of Obstructive Sleep Apnea, 2024 Chulalongkorn University
Mandibular Plane To Hyoid In Lateral Cephalometry As A Predictive Parameter For Severity Of Obstructive Sleep Apnea, Likhit Khattiyawittayakun
Chulalongkorn Medical Journal
Background: Obstructive sleep apnea (OSA) is a common disorder affecting at least 2.0% to 4.0% of the adult population. Early diagnosis and treatment can reduce patient burden. A lateral cephalometric radiograph (LCR) is one method to evaluate upper airway obstruction in patients with OSA.
Objective: This crosssectional study was aimed to investigate the predictive performance of mandibular plane to hyoid (MPH) in LCR for determining the OSA severity.
Methods: One hundred and three adult subjects were analyzed. LCR was performed under standardized processes and measured twice on separate occasions. Receiver operating characteristic (ROC) curve analysis was performed to obtain the …
Depression, Smartphone Addiction And Association Factors Among Preclinical Medical Students, 2024 Chulalongkorn University
Depression, Smartphone Addiction And Association Factors Among Preclinical Medical Students, Aticha Wattanaudomchai
Chulalongkorn Medical Journal
Background: There were few studies of smartphone addiction behavior has been found in preclinical medical students.
Objective: To determine the prevalence and associated factors of depression of smartphone addiction behavior among preclinical medical students of Chulalongkorn University.
Methods: This is a cross-sectional descriptive study. The data were collected from preclinical medical students at Chulalongkorn University in 2020 academic year, prior to COVID-19 pandemic in Thailand. The instruments included the Smartphone Addiction Scale Thai version (SAS-SV-TH), Patient Health Questionnaire-9 Thai version (PHQ-9-T), Pittsburgh Sleep Quality Index Thai version (PSQI-T), and Thai Interpersonal questionnaire. The data were analyzed using SPSS version 25. …
Urinary Oxalate Excretion Is Increased In Calcium Oxalate Nephrolithiasis Patients And Associated With Increased Urinary Capacity Of Calcium Oxalate Crystallization, 2024 Department of Biochemistry, Faculty of Medicine, Chulalongkorn University
Urinary Oxalate Excretion Is Increased In Calcium Oxalate Nephrolithiasis Patients And Associated With Increased Urinary Capacity Of Calcium Oxalate Crystallization, Chanchai Boonla
Chulalongkorn Medical Journal
Background: Calcium oxalate (CaOx) stone is the most common type of stones formed in the urinary tract. Formation of CaOx stone is driven by increased CaOx crystallization in urine.
Objective: To develop a new test, called indole-reacted calcium oxalate crystallization index (iCOCI), and to measure the capability of urine to produce CaOx crystals.
Methods: One hundred samples of 24-h human urine samples obtained from CaOx stone-forming subjects (SFS, n = 50) and non-stone subjects (NSS, n = 50). The levels of oxalate were determined by two methods, i.e., oxalate oxidase method and iCOCI test. Unpaired student t - test, Pearson’s …
Evaluation Of Aspartate Aminotransferase To Platelet Ratio Index And Fibrosis 4 Score For Selecting Patients With Chronic Hepatitis B To Perform Liver Fibrosis Assessment By Transient Elastography In Resource-Limited Areas, 2024 Chulalongkorn University
Evaluation Of Aspartate Aminotransferase To Platelet Ratio Index And Fibrosis 4 Score For Selecting Patients With Chronic Hepatitis B To Perform Liver Fibrosis Assessment By Transient Elastography In Resource-Limited Areas, Puth Muangpaisarn
Chulalongkorn Medical Journal
Background: Liver stiffness measurement operated by transient elastography (TE) becomes a noninvasive method to assess the severity of hepatic fibrosis. However, TE may not be available in resource-limiting areas. Therefore, simple serum biomarker scoring should be evaluated for fibrotic assessment instead of TE.
Objectives: This study aimed to evaluate the diagnostic performance of aspartate. aminotransferase to platelet ratio index (APRI) and fibrosis-4 (FIB-4) scores compared with TE in chronic hepatitis B (CHB) patients and determine the optimal cut-off values to select the CHB patients who should be referred to higher-level hospital for TE evaluation.
Methods: We conducted a cross-sectional study …
Characterization Of Anti-Cancer Properties Of Fungal Metabolite Ophiobolin A, 2024 The University of Texas Rio Grande Valley
Characterization Of Anti-Cancer Properties Of Fungal Metabolite Ophiobolin A, Asma Syed, Rozena Shirvani, Maximiliano Arath Morales, Shizue Mito, Alexander Kornienko, Xiaoqian Fang
Research Symposium
Background: Ophiobolin A (Oph A) is a secondary metabolite and a phytotoxin produced by the pathogenic fungi Cochliobolus heterostrophus that causes “southern corn leaf blight” disease in maize via modulation of the calcium binding protein calmodulin. Numerous studies have found antiproliferative effects of Ophiobolin A against a variety of cells including bacteria and various cancers including melanoma, glioma and leukemia. Recent studies have shown that OphA induces paraptosis-like cell death in glioblastoma multiforme (GBM) cells via vacuolization of the cytoplasm and enlargement of the mitochondria and endoplasmic reticulum. Notably, unlike apoptosis, paraptosis cell death lacks DNA fragmentation and activation …
Intouch Week Of March 4, 2024, 2024 Touro College and University System
Intouch Week Of March 4, 2024, New York Medical College
InTouch
- HeLa Conference Navigates the Future of AI and Health Care Equity
- 2024 Alpha Omega Alpha Inductees Personify the Art of Healing
- Members of SOM Class of 2025 Recognized for Humanism in Medicine
- Department of Pathology, Microbiology and Immunology Hosts Research Symposium
- Advancing Biomedical Research Abroad Through the OVERWORLD Program
- LCME Element of the Week
Prenatal, Perinatal And Postnatal Risk Factors Associated With Autism Spectrum Disorder In Palestine: A Case-Control Study, 2024 Department of biomedical sciences, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Prenatal, Perinatal And Postnatal Risk Factors Associated With Autism Spectrum Disorder In Palestine: A Case-Control Study, Mustafa Ghanim, Mariam Al-Tell, Samaa Staiti, Maha Rabayaa, Johnny Amer, Malik Alqub, Sameeha Atout, Nihad Al-Othman, Marwa Ismail
An-Najah University Journal for Research - B (Humanities)
Background: Autism spectrum disorder (ASD) is a multifactorial neurodevelopment disorder. Several prenatal, perinatal, and postnatal factors are suggested as risk factors for ASD. This study aimed to correlate prenatal, perinatal, and postnatal factors in a limited number of ASD cases in Palestine. Methods: A case-control study involved 120 children (60 typically diagnosed with ASD and 60 healthy matched with the ASD group). The parents of the children in both groups were asked to fill out the questionnaire. Results: The study showed a higher male-to-female ratio in the ASD group. A family history of ASD was reported in 38.3% of the …
Selective Targeting Of Microglia By Quantum Dots And Green Synthesis Of Metal Organic Biohybrids; Applications In Dynamic Cell And Assay Systems, 2024 Louisiana Tech University
Selective Targeting Of Microglia By Quantum Dots And Green Synthesis Of Metal Organic Biohybrids; Applications In Dynamic Cell And Assay Systems, Navya Uppu
Doctoral Dissertations
Neurological disorders are the leading cause of physical and cognitive disability across the globe, currently affecting approximately 15% of the worldwide population. Part of the glioma microenvironment are microglia, resident immune cells of the CNS that were thought to be involved in the pathogenesis of diverse neurodegenerative diseases. Though it remains uncertain what triggers microglial activation in these disorders, targeting and tracking microglial functions using nanotools like Quantum Dots (QDs) could help us elucidate them in such neurological diseases. This research focuses on the comparative study of different QDs formulations and their selective uptake by brain microglia in primary cultures …
Dietary Intake And Continuous Blood Glucose Measurement In Nurses Working Either 12-Hour Day Shifts Or Night Shifts, 2024 Providence
Dietary Intake And Continuous Blood Glucose Measurement In Nurses Working Either 12-Hour Day Shifts Or Night Shifts, Rachel Carlson, Teresa Rangel, Lindsey Miller, Sushana Sudhi
Providence Nursing Research Conference 2023 – Present
Background:
Night shift work is essential in the hospital yet shift work among nurses is linked to negative outcomes such as chronic fatigue and cardiometabolic illnesses. Furthermore, nurses working night shift are more likely to have aberrant glucose levels, defined as greater than 140 mg/dl. Currently, it is unclear whether nurses working night shift eat differently than those working day shift which may explain aberrant glucose levels.
Purpose:
To determine whether night shift nurses have altered glucose levels and dietary intake compared to day shift nurses.
Methods/Approach:
Nurses regularly working full time 12-hour night shifts (n=12) or full time …
The Effects Of Curcumin On Erα, P53, And P21 In The Mcf-7 Breast Cancer Cell Line, 2024 Oakland University
The Effects Of Curcumin On Erα, P53, And P21 In The Mcf-7 Breast Cancer Cell Line, Samantha E. Pfiffner, Mia Morse, Erin Hallman, Kaylin Whittaker, Aisha Zanib, Sumi Dinda Ph.D.
Medical Student Research Symposium
Curcumin is a golden-yellow flavonoid compound derived from the turmeric plant root that has been used in Chinese and Indian medicine for centuries. Curcumin has been shown to have antioxidant and anti-inflammatory properties, and because of this, has been gaining traction in the field of cancer research. Breast cancer is the most commonly diagnosed cancer in women, and is the second leading cause of cancer death in women, next to lung cancer. Because of the prevalence and mortality of breast cancer, possible therapeutics must be investigated. Due to the beneficial properties of curcumin and pervasiveness of breast cancer, we have …
Pessary Use In Urology Clinics, 2024 Wayne State University School of Medicine
Pessary Use In Urology Clinics, Kathy Z. Lu Bs, Emily Brodowsky Md, Alex Stephens Ms, Samantha Raffee Md, Humphrey Atiemo Md
Medical Student Research Symposium
Introduction: Pessaries are a non-invasive treatment option for patients with pelvic organ prolapse (POP) or stress urinary incontinence (SUI). There is currently limited data regarding pessary usage among urology patients. The aim of this study is to determine the patient characteristics that predict long term pessary usage versus surgical intervention.
Methods: A 10-year retrospective review of pessary usage in women with either SUI or POP was performed. Patients were stratified into pessary longevity of less than or greater than one year. Quality of life measures before and after pessary use included pads per day, incontinence symptom index (ISI) scores, and …