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Six-Month Report Assessing The Feasibility And Effectiveness Of Amniotic Membrane Injections In Patients With Short, Anterior, Urethral Strictures, Nicholas Pryde, Jack Vernocke, Aron Liaw, Michael Sessine, Nivedita Dhar 2024 Wayne State University

Six-Month Report Assessing The Feasibility And Effectiveness Of Amniotic Membrane Injections In Patients With Short, Anterior, Urethral Strictures, Nicholas Pryde, Jack Vernocke, Aron Liaw, Michael Sessine, Nivedita Dhar

Medical Student Research Symposium

Introduction: Urethral stricture treatment has high recurrence rates and adjunct injectable agents have been explored. Amniotic membranes (AM) promote apoptosis of pro-inflammatory cells, prevent differentiation of pro-fibrotic cells, and decrease scar formation. These tissues generated interest in reconstructive urethral surgery. Thus, we performed urethral dilation combined with micronized AM injection in urethral scar tissue for treatment of urethral stricture.

Materials and Methods: Adult males with strictures ≤12Fr in diameter and ≤2 cm in length, International Prostate Symptom Score (IPSS) ≥11 and maximum flowrate <15 ml/s. Reconstituted 100mg micronized AM was injected at the time of urethral dilation. Primary study end point was anatomical success (≥14Fr by cystoscopy) at 6 months. Secondary end points were questionnaires, flow rate, and post void residual. Outcomes assessed at baseline, 5 days, 14 days, 3 months, and 6 months post-injection. Safety was analyzed.

Results: Ten men, mean age of 52 ± 15 years, were included. There were 7 patients with …


Adherence To Sb5195 Naloxone Distribution Requirements At Discharge From The Emergency Department, E Stewart, J Delfeld, J McKay, J Corhei, Kailyn Elliot 2024 Providence

Adherence To Sb5195 Naloxone Distribution Requirements At Discharge From The Emergency Department, E Stewart, J Delfeld, J Mckay, J Corhei, Kailyn Elliot

Providence Nursing Research Conference 2023 – Present

Background: Washington State, mirroring a national crisis, experienced a surge in opioid-related deaths, with 17,502 fatalities from 2007 to 2021. This trend aligns with the U.S.'s broader opioid epidemic, marked by 70,000 drug overdose deaths in 2017, data show overdose deaths involving opioids increased from an estimated 70,029 in 2020 to 80,816 in 2021. Overdose deaths were from synthetic opioids, primarily fentanyl. In response, empowering registered nurses (RNs) in emergency departments (EDs) to issue Nurse-Initiated Orders (NIO) for patients to discharge from the hospital with physical naloxone pre-pack kits to be used in the community, an opioid antagonist, has …


Stability Indicating Validated Novel Rp-Hplc Method For Dexlansoprazole And Lc-Ms/Ms Study Of Degradation Product, Ritesh P. Bhole, Chandrakant G. Bonde, Ghansham Girase, Shaliendra Gurav 2024 Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, India. & Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyappeth, Pimpri, Pune, India

Stability Indicating Validated Novel Rp-Hplc Method For Dexlansoprazole And Lc-Ms/Ms Study Of Degradation Product, Ritesh P. Bhole, Chandrakant G. Bonde, Ghansham Girase, Shaliendra Gurav

Palestinian Medical and Pharmaceutical Journal

This work effectively developed and validated a stability-indicating RP-HPLC technique for precisely measuring dexlansoprazole in bulk samples. An Acetonitrile and 0.5 mmol Ammonium Acetate (pH 4.5) gradient mobile phase, a 1 ml/min flow rate, and detection at 283 nm were all part of the method's unique chromatographic conditions. A Kromasil C18 column was also used. Dexlansoprazole had a 5.14-minute retention period, and the technique showed a linear range of 5–30 mg/ml with a strong correlation value of 0.997. The technique showed high sensitivity with a limit of detection (LOD) of 1.2 mg/ml and a limit of quantification (LOQ) of 3.64 …


Prevalence And Associated Factors Of Smartphone Addiction Among Medical And Health Sciences University Students: A Cross-Sectional Study, Adnan Sarhan 2024 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine

Prevalence And Associated Factors Of Smartphone Addiction Among Medical And Health Sciences University Students: A Cross-Sectional Study, Adnan Sarhan

Palestinian Medical and Pharmaceutical Journal

In recent years, dependence on smartphones is seen to be the rise. Despite its numerous communicative affordances, past research suggests potential adverse effects when smartphones are over-used. The primary objective of this study was to estimate the prevalence of Smart Phone Addiction (SPA) as it connects to smartphone usage and associated factors among An-Najah medical and health sciences students in Palestine. A cross-sectional design and convenient sampling technique were used to select eligible students from different programs in the faculty of Medicine and Health Sciences at the An-Najah National University. Three hundred sixty-seven students were recruited. The Smartphone …


Head-To-Head Comparison Between Magnetic Resonance Imaging And Arthroscopy Findings For Ligamentous And Meniscal Knee Injuries: A Cross-Sectional Observational Study In Palestine, Zada Hamad, Ali Hewari, Aminah Birawi, Ahmed Awadghanem, Mazen Abdalla, Mohammad M. Jaber, Mosab Maree 2024 Department of Medicine, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine

Head-To-Head Comparison Between Magnetic Resonance Imaging And Arthroscopy Findings For Ligamentous And Meniscal Knee Injuries: A Cross-Sectional Observational Study In Palestine, Zada Hamad, Ali Hewari, Aminah Birawi, Ahmed Awadghanem, Mazen Abdalla, Mohammad M. Jaber, Mosab Maree

Palestinian Medical and Pharmaceutical Journal

Background: Traumatic knee injuries are widespread, especially among young adults; when a clinical exam suspects the diagnosis, it is evaluated by magnetic resonance imaging (MRI) and confirmed by arthroscopy. MRI is non-invasive and saves patients from potential general anesthesia and surgical site infection complications. We aim to assess the precision of ligamentous and meniscal injuries by MRI compared to the gold standard knee arthroscopy. Methods: We performed a cross-sectional observational study at An-Najah University Hospital (NNUH). Patients who underwent knee arthroscopic surgery and had preoperative MRIs were included in this study. The magnetic resonance and intraoperative findings during …


Knowledge, Attitude, And Practice Regarding Deep Dentinal Caries Removal Before Root Canal Treatment And Restoration Among Practicing Dental Surgeons, Sangram Panda, Anamika Sinha, Shakti Rath, Kajal Kiran Sahoo 2024 Department of Prosthodontics and Crown & Bridge, Institute of Dental Sciences, Siksha ‘O’ Anusandhan (Deemed to be) University, Bhubaneswar, Odisha, India

Knowledge, Attitude, And Practice Regarding Deep Dentinal Caries Removal Before Root Canal Treatment And Restoration Among Practicing Dental Surgeons, Sangram Panda, Anamika Sinha, Shakti Rath, Kajal Kiran Sahoo

Palestinian Medical and Pharmaceutical Journal

This article aims to determine the knowledge, attitude, and practice regarding Deep Dentinal Caries Removal before Root Canal Treatment (RCT) and Restoration among practicing dental surgeons. A descriptive cross-sectional study was executed amongst dental surgeons practicing with undergraduate and post-graduate degrees. A Google questionnaire form was developed and distributed, and 111 authentic entries were short-listed. Data obtained from the study were recorded in Microsoft Excel 2007 version, and SPSS version 18.0 was used for statistical analysis. Most dental surgeons who participated in the study practiced for over 15-20 years. Among them, 60% believe in removing dentinal caries before RCT; 83.8% …


Illness Perceptions In Patients With Coronary Artery Disease In A Private Hospital In Malaysia, Ahmed Nouri, Jufine Majalu, Maha Aldraimly, Nahid A. Lamfon, Nourah Al enazi, Manahel Alshaer, Reem Fahad alanazi, Nouf Alanazi 2024 College of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine

Illness Perceptions In Patients With Coronary Artery Disease In A Private Hospital In Malaysia, Ahmed Nouri, Jufine Majalu, Maha Aldraimly, Nahid A. Lamfon, Nourah Al Enazi, Manahel Alshaer, Reem Fahad Alanazi, Nouf Alanazi

Palestinian Medical and Pharmaceutical Journal

Background: The prevalence of Coronary Artery Disease (CAD) makes it a significant public health concern. Studies on illness perceptions have established a clear correlation between patients' beliefs and the outcomes of their recovery from various illnesses and risk factors. As a result, gaining a deeper understanding of patients' illness perceptions of CAD is imperative for nurses, as it enables them to provide more tailored education and interventions. This, in turn, can improve patient outcomes and reduce the overall burden of CAD. Aim: The study aims to determine the illness perceptions in patients with coronary artery disease in an …


Percutaneous Coronary Intervention In Unprotected Left Main Coronary Artery Stenosis Patients. A Retrospective Study From Palestine, Yunis Daralammouri, Hamza Hamayel, Raya Yassin, Ameer Kittaneh, Aya Asaly, Zaher Nazzal, Yahya Ismail 2024 Department of Cardiology and Catheterization, An-Najah National University Hospital, Nablus, Palestine

Percutaneous Coronary Intervention In Unprotected Left Main Coronary Artery Stenosis Patients. A Retrospective Study From Palestine, Yunis Daralammouri, Hamza Hamayel, Raya Yassin, Ameer Kittaneh, Aya Asaly, Zaher Nazzal, Yahya Ismail

Palestinian Medical and Pharmaceutical Journal

Objective: The study aimed to assess the results of stenting in unprotected left main coronary artery disease (uLMCAD) at a tertiary hospital center. Methods: We assessed all patients who received stenting for uLMCAD, including stable patients who underwent elective, urgent, or emergent procedures. Data were gathered by reviewing hospital records and coronary angiograms and calculating SYNTAX scores. Patient follow-up was conducted via clinic visits and phone calls. Results: Percutaneous coronary intervention (PCI) was performed on seventy patients with uLMCAD, all of whom had successful revascularization. During their hospital stay, only one patient (1.4%) died from a noncardiac cause and no …


Prevalence Of Vitamin D Deficiency Among Acute Coronary Syndrome Patients In Palestine, Iyad Ali, Ahmad Khalil, Alaa Daibes, Khaled Qushair, Ahmed Al-Sabi, Muhammad Yasser Alsedfy, Hassan Kanj, Mahmoud Abuissa, Kamel Jebreen 2024 Department of Medical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine

Prevalence Of Vitamin D Deficiency Among Acute Coronary Syndrome Patients In Palestine, Iyad Ali, Ahmad Khalil, Alaa Daibes, Khaled Qushair, Ahmed Al-Sabi, Muhammad Yasser Alsedfy, Hassan Kanj, Mahmoud Abuissa, Kamel Jebreen

Palestinian Medical and Pharmaceutical Journal

Introduction: Research has suggested that having low Vitamin D levels is associated with a higher likelihood of developing cardiovascular disease. Specifically, several observational studies have found that Vitamin D is linked to a decreased risk of coronary artery disease. Our study aimed to determine how prevalent Vitamin D deficiency is in Palestinian patients with acute coronary syndrome, a type of cardiovascular disease. Methods: This study used a cross-sectional design, which involved collecting 84 blood samples from patients diagnosed with acute coronary syndrome at two hospitals in Palestine. The blood samples were collected over approximately two months, from late January to …


Investigation Of Antidiabetic Of Antidiabetic Activity And Pharmacokinetics In Herbo-Mineral Ayurvedic Formulation ‘Arogyavardhini Gutika In Streptozotocin Induced Wistar Rat, Ruchi Bhattacharya, BINA GIDWANI Prof., Shiv Shankar Shukla Prof., Ravindra Kumar Pandey Prof. 2024 Research Scholar, Department of Pharmacology, Columbia Institute of Pharmacy, Raipur (C.G.), India

Investigation Of Antidiabetic Of Antidiabetic Activity And Pharmacokinetics In Herbo-Mineral Ayurvedic Formulation ‘Arogyavardhini Gutika In Streptozotocin Induced Wistar Rat, Ruchi Bhattacharya, Bina Gidwani Prof., Shiv Shankar Shukla Prof., Ravindra Kumar Pandey Prof.

Palestinian Medical and Pharmaceutical Journal

Aim: Herbs, spices, and minerals are important therapeutic attributes of ayurvedic formulations. The formulation Arogyavardhini Gutika is mentioned in the essential drug list of the Ayurvedic Formulary of India. It has a claimed safety profile and is used for the treatment of jaundice, leprosy, fever, oedema, obesity, skin disorders, and other hepatic issues. Methods: An in- vitro study was performed by alpha-amylase inhibition using starch, iodine, and dinitrosalicyclic acid. An in-vivo study was performed using a streptozotocin-induced diabetic rat model. Graded doses of Arogyavardhini gutika (200 and 500 mg/kg) were administered orally for 14 days to normal and streptozotocin-induced …


Substance Use Disorder (Sud)- The Impact Of Sud In Utah, Amber Escobedo 2024 Roseman University of Health Sciences

Substance Use Disorder (Sud)- The Impact Of Sud In Utah, Amber Escobedo

Annual Research Symposium

Substance use disorder (SUD) is a manageable mental disorder that causes affected individuals to lose control over their use of substances such as drugs or alcohol. The cost of this disorder leads to the loss of billions of dollars each year. The purpose of this study is to explore ways to minimize the cost SUD bring to Utah and the United States.


Pharmacist Interventions Increase Uptake Of Pneumonia Vaccination In At-Risk Populations: A Review., Kaitlyn Hinton 2024 Roseman University of Health Sciences

Pharmacist Interventions Increase Uptake Of Pneumonia Vaccination In At-Risk Populations: A Review., Kaitlyn Hinton

Annual Research Symposium

Pneumonia is a large burden to healthcare costs and a large cause of hospitalization (Hayes, BH. Chest. 2018, 153(2), 427), and bacterial pneumonia can be prevented through vaccination. While pediatric vaccinations are routinely given, an additional dose is required for adults 65+ years of age or otherwise immune compromised, including diabetics. Only 22.2% of Immunocompromised patients and 65% of the elderly population have received the extra dose (Hung, MC. CDC. 2022). With pharmacist interventions, these vaccination rates could increase significantly. The purpose of this study was to conduct a review of the literature to identify interventions that have yielded higher …


Medication Errors Among Als Providers In The Prehospital Setting, Cody Vaughn Gibson, Victor Jimenez Jr 2024 William Woods University

Medication Errors Among Als Providers In The Prehospital Setting, Cody Vaughn Gibson, Victor Jimenez Jr

Annual Research Symposium

EMS providers administer a variety of medications to patients in the prehospital environment, and while there are numerous published studies on medication errors pertaining to the hospital environment, there are comparatively fewer studies which focus on the prehospital environment. Therefore, the purpose of this survey is to investigate the type and frequency of medication errors occurring in the prehospital environment.


Evaluation Of Novel Therapeutic Agents For The Treatment Of Chronic Dry Eyes, Lilian Huynh, Evonie Villarete, Surajit Dey 2024 Roseman University of Health Sciences

Evaluation Of Novel Therapeutic Agents For The Treatment Of Chronic Dry Eyes, Lilian Huynh, Evonie Villarete, Surajit Dey

Annual Research Symposium

Dry eye disease (DED) is a multifactorial ocular condition, where disrupted tear film stability and ocular surface inflammation affected between 5% to 34% of the worldwide population in 2015 and posed a challenge to conventional ophthalmic treatments. Recent advances have led to potential novel therapeutics aiming to alleviate symptoms and improve patient outcomes.


A Cost Variation Analysis Of Various Statin Preparations Available In The Egyptian Market, Radwa Ahmed Ibrahim, Marwa G. Elhennawy, Samar F. Farid 2024 BSc Faculty of Pharmacy, Cairo University, Cairo, Egypt, 11562

A Cost Variation Analysis Of Various Statin Preparations Available In The Egyptian Market, Radwa Ahmed Ibrahim, Marwa G. Elhennawy, Samar F. Farid

Bulletin of Faculty of Pharmacy Cairo University

Introduction: Dyslipidemia is one of the main risk factors for cardiovascular diseases. Statin preparations are the most effective lipid-lowering preparations that reduce the risk of mortality related to cardiovascular diseases. In the Egyptian market, various statin preparations have different strengths and prices. Aim: The current study aims to assess the percentage of cost variations among different statin medications in the Egyptian market. Methods: This is a cost variation study conducted from November to December 2022. The data were collected by using the Egyptian master on therapeutic drugs, edition 2022, and from the Egyptian Drug Database (DDB) website. The maximum and …


Analysis Of Us Food And Drug Administration New Drug And Biologic Approvals, Regulatory Pathways, And Review Times, 1980–2022, Enrique Seoane-Vazquez, Rosa Rodriguez-Monguio, John H. Powers III 2024 Chapman University

Analysis Of Us Food And Drug Administration New Drug And Biologic Approvals, Regulatory Pathways, And Review Times, 1980–2022, Enrique Seoane-Vazquez, Rosa Rodriguez-Monguio, John H. Powers Iii

Pharmacy Faculty Articles and Research

U.S. laws enacted since 1983 have aimed to enhance the development and marketing of new pharmaceutical products. We thoroughly characterized all new molecular entities, therapeutic biologics, and gene and cell therapies approved by the US Food and Drug Administration (FDA) during the period 1980–2022 in the context of these laws and regulations. Throughout the study period, the FDA approved 1355 new pharmaceutical products. The median FDA review time decreased from 26.6 months prior to the Prescription Drug User Fee Act (1992), which authorized the FDA to collect fees from drug companies to 9.9 months after the Food and Drug Administration …


Quantifying Community-Based Pharmacy Student Operational And Clinical Rotation (Ippe) Activities., Kenneth Kunke, Phillip Lawrence, C. Leiana Oswald, Erin Johanson, Michelle Hon 2024 Roseman University of Health Sciences

Quantifying Community-Based Pharmacy Student Operational And Clinical Rotation (Ippe) Activities., Kenneth Kunke, Phillip Lawrence, C. Leiana Oswald, Erin Johanson, Michelle Hon

Annual Research Symposium

The purpose of this study is to identify and describe trends in the quantity and proportion of operational and clinical activities performed by students on introductory (IPPE) rotations.


Nanoemulsion Formulation Of Pregabalin For Enhanced Nose To Brain Delivery And Biological Tracking Using Radiolabeling With 99mtc, Hend Fayez, Adli A. Selim, Rehab N. Shamma, Hassan M. Rashed 2024 Labeled Compounds Department, Hot Laboratories Center, Egyptian Atomic Energy Authority, Cairo, Egypt

Nanoemulsion Formulation Of Pregabalin For Enhanced Nose To Brain Delivery And Biological Tracking Using Radiolabeling With 99mtc, Hend Fayez, Adli A. Selim, Rehab N. Shamma, Hassan M. Rashed

Bulletin of Faculty of Pharmacy Cairo University

Pregabalin is a γ-aminobutyric acid analogue used for the treatment of neuropathic pain, seizures, and anxiety disorders. After oral administration, its level of brain penetration is rather modest. In this research, pregabalin was formulated successfully as a nanoemulsion. To track the biodistribution of pregabalin nanoemulsion in vivo, radiolabelling of pregabalin using 99mTc was performed. The different factors affecting radiolabeling yield were studied and radiolabelling yield of 92.6 % was achieved. A biological evaluation was performed in Swiss Albino mice through comparing biodistribution of intranasal (IN) 99mTc-pregabalin nanoemulsion with intravenous (IV) 99mTc-pregabalin solution at different time intervals. Biodistribution results show a …


Targeting Strategies To Optimize The Therapeutic Potential Of Gold Compounds Against Her2-Positive Breast Cancers, Afruja Ahad 2024 The Graduate Center, City University of New York

Targeting Strategies To Optimize The Therapeutic Potential Of Gold Compounds Against Her2-Positive Breast Cancers, Afruja Ahad

Dissertations, Theses, and Capstone Projects

The overexpression of HER2 accounts for 20-30% of breast cancer tumors and not only serves as a marker for poor predictive clinical outcomes but also as a target for treatment. Antibody-drug conjugates (ADCs) combine the selectivity of monoclonal antibodies (mAbs) with the efficacy of chemotherapeutic drugs to provide targeted treatment without toxicity to normal tissue. Most of the ADCs currently in the clinic for cancer chemotherapy are based on complex organic molecules. In contrast, the conjugation of metallodrugs to mAbs has been overlooked when there is enormous potential in this area with the resurgence of metal-based drugs as prospective cancer …


Tbi And Tau Loss-Of-Function Both Affect Naïve Ethanol Sensitivity In Drosophila, Gregg Roman 2024 University of Mississippi

Tbi And Tau Loss-Of-Function Both Affect Naïve Ethanol Sensitivity In Drosophila, Gregg Roman

Faculty and Student Publications

Traumatic brain injury (TBI) is associated with alcohol abuse and higher ethanol sensitivity later in life. Currently, it is poorly understood how ethanol sensitivity changes with time after TBI and whether there are sex-dependent differences in the relationship between TBI and ethanol sensitivity. This study uses the fruit fly Drosophila melanogaster to investigate how TBI affects alcohol sensitivity and whether the effects are sex-specific. Our results indicate that flies have a significantly higher sensitivity to the intoxicating levels of ethanol during the acute phase post-TBI, regardless of sex. The increased ethanol sensitivity decreases as time progresses; however, females take longer …


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