CUNY Queensborough Community College
North Carolina State University at Raleigh
University of Maine - Main
Flippase Inhibitors As Antimicrobial Agents,
2022
Seton Hall University
Flippase Inhibitors As Antimicrobial Agents, Robert Tancer
Seton Hall University Dissertations and Theses (ETDs)
Drug resistant microbes are a considerable challenge for modern medicine to overcome. The research described in this dissertation involved development of lipid flippase inhibitors and investigating their potential as antimicrobial agents against various drug resistant microbes. The microbes primarily investigated were methicillin resistant Staphylococcus aureus (MRSA) & Cryptococcus neoformans. Chapter 1 reviews the historical perspective and summarizes the current state of the field of research. In Chapter 2, the design space of an antimicrobial peptide known as humimycin was explored and the effects of modifications on its structure were observed against MRSA. Several key observations resulted. Most notably, the nanoparticles formed ...
A Fatal Case Of Covid-19 Pneumonia In A Fully Vaccinated Heart Transplant Recipient,
2022
University of Louisville
A Fatal Case Of Covid-19 Pneumonia In A Fully Vaccinated Heart Transplant Recipient, Agastya D. Belur, Diana Otero, Christina Dunbar Matos
The University of Louisville Journal of Respiratory Infections
The development and administration of mRNA vaccines against SARS-CoV-2 are seeing lower numbers of COVID-19 cases and fatalities among fully vaccinated, immunocompetent adults. We present a case of fatal COVID-19 pneumonia in a heart transplant recipient who had received two doses of mRNA COVID-19 vaccine before the Centers for Disease Control and Prevention had recommended additional doses.
Covid-19, Vaccination, And Heart Transplantation,
2022
University of Louisville
Covid-19, Vaccination, And Heart Transplantation, Forest W. Arnold
The University of Louisville Journal of Respiratory Infections
No abstract provided.
Neurosyphilis: A Monkey Among Men,
2022
Cape Fear Valley Medical Center
Neurosyphilis: A Monkey Among Men, Cameron Rowe Do, Nathan Buckley Do, Bhaskar Chhetri Md, Suresh Paudel Md
Journal of Community Hospital Internal Medicine Perspectives
Neurosyphilis is the progression of the untreated sexually transmitted infection caused by Treponema pallidum. When the initial infection is not adequately treated, progression of primary syphilis can lead to a wide variety of serious health sequelae. While neurosyphilis can appear up to 10-30 years after the initial infection, syphilis can invade the nervous system at any stage of infection and can imitate symptoms of many other diseases. This variety of symptoms is why syphilis has been called “The Great Pretender” or “The monkey among diseases” (12). This is a case report of an 83-year-old female with a history of multiple ...
Bacteriophages: Paving The Road For The Future Of Medicine,
2022
Ouachita Baptist University
Bacteriophages: Paving The Road For The Future Of Medicine, Luke Brinkerhoff
Honors Theses
Bacteriophages are a possible solution to antibiotic resistance, which is predicted to be detrimental world-wide by the year 2050. Personal field research was also conducted for a project studying the characteristics of two bacteriophages on a single bacterial host.
Investigation On Bacterial Signaling Through Generation Of A Ppgpp Biosensor,
2022
East Tennessee State University
Investigation On Bacterial Signaling Through Generation Of A Ppgpp Biosensor, Andrew Robinson
Undergraduate Honors Theses
Guanosine tetraphosphate (ppGpp) is a bacterial signaling molecule involved in activating the stringent response, a cellular reaction to environmental stress that downregulates cell division and metabolism processes to conserve nutrients. The stringent response is implicated in some instances of antibiotic persistence, so broadening the current understanding of ppGpp signaling is useful. This thesis seeks to generate a ppGpp biosensor that will bind ppGpp and emit fluorescent light in its presence, which will allow for improved research into the pathways and functions of the signaling molecule. To generate a novel ppGpp biosensor, I converted a biosensor previously used to detect cyclic ...
Bartonella Henselea Prosthetic Valve Endocarditis Mimicking Vasculitis: A Case Report With Literature Review,
2022
University of Central Florida, School of Medicine/HCA Florida North Florida Hospital
Bartonella Henselea Prosthetic Valve Endocarditis Mimicking Vasculitis: A Case Report With Literature Review, Troy J. Fishman, Efrain Irizarry, Ayesha Kaleem, Robert Yancey, Uma Iyer
HCA Healthcare Journal of Medicine
We present one of the first reported cases of Bartonella henselae prosthetic valve endocarditis, which mimicked p-antineutrophil cytoplasmic autoantibody (p-ANCA), an anti-proteinase 3 positive necrotizing glomerulonephritis caused by a cat scratch resulting in temporary dialysis. Documentation of such infections is necessary as zoonotic infections are becoming more prevalent with early identification essential for proper treatment. Although pauci-immune patterns are not a unique finding in bacterial endocarditis associated with glomerulonephritis, they are an atypical finding in Bartonella henselae endocarditis. Furthermore, p-ANCA-associated vasculitis can also be responsible for renal and cardiac disease. Because of the similar disease presentation of different etiologies (autoimmune ...
Covid-19 Case Complicated With Organizing Pneumonia And Pneumothorax: A Case Report,
2022
University of Central Florida College of Medicine
Covid-19 Case Complicated With Organizing Pneumonia And Pneumothorax: A Case Report, Tammy E. Phillips, Hammad A. Bhatti, Minh Q. Ho
The University of Louisville Journal of Respiratory Infections
Organizing pneumonia can be idiopathic or caused by multiple etiologies, including viral or bacterial pneumonia, drugs, and autoimmune disorders. It can rarely lead to cyst formation and pneumothorax with the exact mechanism remaining unclear. This case presents a previously healthy 50-year-old male who contracted COVID-19 with subsequent development of organizing pneumonia and pneumothorax. Patients presenting with hypoxic respiratory failure due to COVID-19 should be screened for organizing pneumonia upon discharge. This case also illustrates the importance of following such patients radiologically to monitor interstitial lung disease and consider pneumothorax for patients re-presenting with acute symptoms.
Author Correction: Short Amylin Receptor Antagonist Peptides Improve Memory Deficits In Alzheimer’S Disease Mouse Model,
2022
University of Alberta
Author Correction: Short Amylin Receptor Antagonist Peptides Improve Memory Deficits In Alzheimer’S Disease Mouse Model, Rania Soudy, Ryoichi Kimura, Aarti Patel, Wen Fu, Kamaljit Kaur, David Westaway, Jing Yang, Jack Jhamandas
Pharmacy Faculty Articles and Research
Correction to: Scientific Reports https://doi.org/10.1038/s41598-019-47255-9, published online 29 July 2019
The original Article contained an error in Figure 1A where the control trace for both the HEK-AMY3 and HEKWT cells was duplicated...
The original Article has been corrected.
Bacteriophages: Paving The Road For The Future Of Medicine,
2022
Ouachita Baptist University
Bacteriophages: Paving The Road For The Future Of Medicine, Luke Brinkerhoff
Scholars Day Conference
Antibiotics will not be used forever by society due to antibiotic resistance. By the year 2050, it is predicted to have caused millions of casualties throughout the world. Thankfully, bacteriophages and phage therapy could be a potential solution to this problem.
New Paenibacillus Bacteria Genome Assembly,
2022
Ouachita Baptist University
New Paenibacillus Bacteria Genome Assembly, Makenna Kager
Scholars Day Conference
Due to DLA16’s ability to produce antibiotics it was selected for whole genome sequencing.
Diversity Of Bacteriophage In Burkholderia Species,
2022
Bowling Green State University
Diversity Of Bacteriophage In Burkholderia Species, Abigail Price
Honors Projects
Bacteriophages are viruses that infect and replicate within bacteria and offer the potential of a therapeutic alternative to chronic infections that do not respond to antibiotic-based therapies. B. vietnamiensis is one of a number of Burkholderia species involved with chronic drug resistant infections in the lungs of individuals with compromised respiratory systems, as found in those with chronic obstructive pulmonary disease and, most especially, are of particular significance in patients with cystic fibrosis. The diversity of the Burkholderia species is explored by using online databases and looking at bacteriophage or phage-encoding viruses found in B. vietnamiensis. The open reading frames ...
Predominantly Methicillin-Susceptible S. Aureus Bacteria Found In Csp Students’ S. Aureus Strains,
2022
Concordia University, St. Paul
Predominantly Methicillin-Susceptible S. Aureus Bacteria Found In Csp Students’ S. Aureus Strains, Roma Ambo
Research and Scholarship Symposium Posters
Positive Staphylococcus aureus strains from CSP students were tested for methicillin resistance (MRSA) using the Kirby-bauer assay. Kirby-bauer assay technique was used to determine the sensitivity of staphylococcus aureus bacteria against oxacillin. MRSA infection is the result of a bacteria that has built resistance against the antibiotics used to treat staph infections. The results of this experiment concludes that majority of the strains tested are methicillin-susceptible S. aureus (MSSA).
Sotrovimab: Neutralizing Antibody To Combat Covid-19,
2022
Menoufia University
Sotrovimab: Neutralizing Antibody To Combat Covid-19, Aya Allam, Steven Lippmann
The University of Louisville Journal of Respiratory Infections
No abstract provided.
Are Antipyretic Medications Compatible With Sars-Cov-2 Vaccines?,
2022
University of Louisville
Are Antipyretic Medications Compatible With Sars-Cov-2 Vaccines?, Sharanya S E Santhi, Niguma Rayamajhi, Steven B Lippmann
The University of Louisville Journal of Respiratory Infections
No abstract provided.
Mucormycosis: Covid-19 And Corticosteroids,
2022
Gujarat Medical Education and Research Society Medical College
Mucormycosis: Covid-19 And Corticosteroids, Mittal Savaliya, Nivedita Jha, Steven B Lippmann
The University of Louisville Journal of Respiratory Infections
No abstract provided.
Investigating Alternative Induction Of The S. Aureus 80a Prophage,
2022
University of Lynchburg
Investigating Alternative Induction Of The S. Aureus 80a Prophage, Jody Caretti
Student Scholar Showcase
Widespread antibiotic resistance has quickly become one of the most concerning crises affecting modern medicine, especially in cases of Staphylococcal infections, which have become resistant to all ��-lactam antibiotics. As a result, research into alternative forms of treatment for bacterial infections is a top priority. Bacteriophage therapy is a popular candidate for replacing antibiotics, due to the way the viruses interact with the bacteria. The 80�� prophage integrates its DNA into Staphylococcus aureus strain 10616 via the lysogenic cycle, and replicates with the bacterial cell. When stressed, the bacteria stop replicating and the prophage stimulates the lytic cycle, activating transcription ...
Urinary Incontinence: Understanding The Silent Plight Of Women,
2022
Aga Khan University
Urinary Incontinence: Understanding The Silent Plight Of Women, Yasmin Nadeem Parpio, Anmol Minaz, Sonia Ijaz Haider
School of Nursing & Midwifery
Urinary incontinence (UI) is defined as the complaint of involuntary loss of urine. UI affects both men and women but is more common in women. It has been identified as a World Health Organization priority. The burden related to UI at local, national, and global levels is huge and its impact in terms of physical, social, mental, and financial aspects makes it a concerning issue. However, there exist several barriers in terms of knowledge and attitude in seeking healthcare among women experiencing UI. This calls upon a multi-disciplinary approach involving professionals from different disciplines and tackling it with collaborative and ...
Outcomes Of Vancomycin Minimum Inhibitory Concentration In Methicillin-Resistant Coagulase-Negative Staphylococcal Bacteremia,
2022
Roseman University of Health Sciences
Outcomes Of Vancomycin Minimum Inhibitory Concentration In Methicillin-Resistant Coagulase-Negative Staphylococcal Bacteremia, Theresa Tran
Annual Research Symposium
No abstract provided.
A Quantitative Analysis Of The Efficacy Of Various Essential Oils Against The Sars Cov-2 Virus,
2022
Brigham Young University - Provo
A Quantitative Analysis Of The Efficacy Of Various Essential Oils Against The Sars Cov-2 Virus, Elizabeth Wagstaff, Chandrelyn Kraczek, Jack Brandon Lopez
Annual Research Symposium
A poster presentation and abstract for the Roseman Symposium. The project focuses on testing 3 essential oil blends and two disinfectants containing an essential oil blend against SARS CoV-2 in response to the COVID-19 pandemic. The project procedure involves plaque assays, disinfection, and neutralization techniques.
