Alternative and Complementary Medicine Commons^™

Using Noninvasive Calibrated Cuff Plethysmography To Observe The Effects Of Cold-Water Immersion On Arterial Compliance, Rita M. Grigorian

Biomedical Engineering: Graduate Reports and Projects

As the prevalence of cardiovascular diseases continues to exponentially grow in populations across the globe, the necessity of determining underlying factors, effective methods of diagnoses, and universally available preventive measures also grows. Early detection of endothelial dysfunction, a proven precursor of cardiovascular diseases, can be extremely impactful in encouraging preventative measures and early intervention before medical conditions become chronic. In recent years, ice plunging, a form of cryotherapy involving full body immersion in cold water, has gained popularity within circles of fitness and health practitioners, gaining the interest of people of all backgrounds. Certain parallels observed between the human physiological …

Bioengineered Nisin A Derivatives Display Enhanced Activity Against Clinical Neonatal Pathogens, Anna Desmond

ORBioM (Open Research BioSciences Meeting)

Neonatal infection is a significant cause of mortality and morbidity in infants. Globally, neonatal pathogens are increasingly becoming multi-drug resistant, indicating the need to discover novel alternative treatment strategies. Nisin is an antimicrobial peptide that exhibits broad-spectrum activity against Gram-positive and Gram-negative bacteria including a wide variety of clinical pathogens. Nisin can be used in combination with antibiotics to improve their efficacy. This study examined the activity of nisin and bioengineered derivatives against multi-drug resistant Streptococcus agalactiae and Staphylococcus capitis isolates and investigated the potential synergy between nisin peptides and selected antibiotics. Whole genome sequence analysis of the strains revealed …

The Addition Of Nature To The Patient's Healing Regimen, Katelyn Lewis, Audrey Henry

Scholars Week

Through our scholarly research, we have found many benefits to the use of nature to help facilitate healing within patients. Our project aims to spread awareness of the positive aspects of nature during the healing process. Specifically, our research focuses on healing gardens and outside therapy for patients. Our presentation is based upon Nightingales' theory of the environment. Our hope is that facilities will implement the addition of nature to the patient's plan of care.

Effects And Treatments Of Depression Affecting Patient Outcomes, Parker Gerard

Scholars Week

No abstract provided.

Development Of A Novel Serum Formulation For The Treatment Of C. Acnes, Ariana G. Ngue

Harrisburg University Research Symposium: Highlighting Research, Innovation, & Creativity

Acne impacts 85% of people between 12-24 years of age. Even after puberty, acne continues to impact a large portion of the population. The treatments are diverse and include prescription drugs. Through this research, a novel formulation was created for the skin to treat acne. This formulation incorporates salicylic acid, a non-prescription acne treatment, as well as a polymeric carbohydrate (hyaluronic acid) known to be a component of skin and involved in the healing of skin. Through an internship with Island Lux Essentials, a company devoted to making all natural body care products, a novel serum formulation was created to …

In Silico Prediction Of Sodium-Glucose Co-Transporter-2 (Sglt2) Inhibition Activity By Allium Fistulosum Compound Based On Skelspheres Molecular Descriptor, Rudy Heryanto, Aryo Tedjo, Dimas Noor

Indonesian Journal of Medical Chemistry and Bioinformatics

The Sodium-Glucose co-transporter-2 (SGLT2) inhibitor represents a novel agent for the treatment of type 2 diabetes. Drugs of this class function by inhibiting glucose reabsorption in the kidneys, thereby controlling blood glucose levels. It is known that SGLT2 inhibitors activate the AMPK signaling pathway by increasing the expression and activity of AMP-activated protein kinase (AMPK). In vivo tests have demonstrated that ethanolic and aqueous extracts of Welsh onion leaves (Allium fistulosum L) can reduce body weight, liver weight, adipocyte size, and enhance AMP-activated protein kinase (AMPK) expression. In this study, the inhibitory activity (IC50) of compounds within Allium fistulosum against …

Metabolomic Insights Into Tuberculosis: Machine Learning Approaches For Biomarker Identification, Miftahul Khair Akbar, Arief Aulia Rahman

Indonesian Journal of Medical Chemistry and Bioinformatics

The lung parenchyma is largely impacted by the infectious condition known as pulmonary tuberculosis (pulmonary TB) when the immune system creates a wall around the germs in the lungs, a tiny, hard bulge known as a tubercle develops, earning the disease the name tuberculosis. Although the majority of TB germs target the lungs, they can also harm other bodily organs. The identification of TB biomarkers, which are crucial for diagnosis, treatment monitoring, risk analysis, and prognosis, has been the subject of extensive research. Differences in metabolites between normal cells and tuberculosis are considered to be able to support the diagnosis …

The Effects Of Herbal Products In Cartilage Healing And Reducing The Progression Of Osteoarthritis, Mariya Baig, Mir Saleem

Mako: NSU Undergraduate Student Journal

Treatment for osteoarthritis (OA) includes symptom management with nonsteroidal anti-inflammatory drugs (NSAIDs), opioids, and acetaminophen. However, these drugs pose health risks for long-term use, such as contraindications and gastrointestinal/cardiovascular issues. This systematic review of the literature was conducted to evaluate the impact of the herbal products, turmeric and ginger, in cartilage healing and reducing the progression of OA. It was found that turmeric and ginger can aid in symptom management for OA and promote cartilage regeneration, with turmeric extract yielding greater evidence-based results. Turmeric reduces the amount of pain and stiffness experienced from OA and can restore cartilage by subduing …

Thymoquinone Inhibits Prostate Cancer Progression By Modulating Cytochrome P450 (Cyps), Santosh K. Singh, Rajesh Singh

Research Symposium

Background: Prostate cancer (PCa) incidence and mortality remain high in African American (AA) than Caucasian American (CA) men. Multiple factors contribute to this critical disease disparity, androgen receptors (AR), and differences among variants of the genes such as Cytochrome P450 (CYP) are involved in androgen biosynthesis and metabolism that may switch to gene regulation for prostate growth. However, inhibitors have been approved for CYP genes, the major pitfall, undesirable side effects, and quality of life in those patients. Therefore, targeting CYPs with a natural compound, Thymoquinone (TQ), a constituent of Nigella sativa (black seed), potentially safe and curative option for …

Targeting Cellular Signaling Pathways In Cancer By Lactobacilli, Varish Ahmad, Aftab Ahmad, Quazi Muhammad Sajid Jamal

Research Symposium

Purpose: Presenting lactobacilli therapy for cancer treatment targeting cancer signaling Lactobacilli as Probiotic lactic acid bacteria (LAB) are a group of fermentative gram-positive and gram-negative bacteria that produces a large number of intracellular and extracellular metabolites used in the food manufacture industry as well as complementary and alternative medicines against many diseases including cancer.

Description: Some LAB has been found to have inhibitory activity against colon liver cancer, cancer, colorectal cancer, breast cancer, and lung cancer in vivo or in vitro. These fermentative bacteria induced the autophagy cell death either by GRP78 and Beclin-1 or by induction of Bak …

Stress-Induced Changes In Carf Expression Determine Growth Arrest, Apoptosis, Or Malignant Transformation In Cultured Human Cells: Molecular Evidence And Its Application, Mallika Khurana, Rajkumar Singh Kalra, Anupama Chaudhary, Amr Omar, Xiaoshuai Li, Sunil C. Kaul, Renu Wadhwa

Research Symposium

Background: CARF (Collaborator of ARF)/CDKN2AIP is an essential protein, first cloned as a binding partner of ARF. It was subsequently shown to interact with p53, HDM2 proteins and regulate growth arrest and apoptosis by its multimodal mechanism of action. Over-expression of CARF caused senescence like growth arrest of cells, its knock-down triggered apoptosis. Intriguingly, malignantly transformed cells showed high level of CARF expression. Based on these findings, we hypothesized that level of CARF expression may be a key determinant of cell proliferation fates; where an increase in its levels causes growth arrest/senescence, but beyond a threshold it activates carcinogenesis.

Methods: …

Piperine Encourages Apoptosis In Human Cervical Adenocarcinoma Cells Through Ros Generation, Dna Fragmentation, Caspase-3 Activation And Cell Cycle Arrest, Asif Jafri, Juhi Rais, Sudhir Kumar, Md Arshad

Research Symposium

Background: Cancer is one of the most common destructive diseases and the second leading cause of death in humans. Among cancer, cervical cancer is the second most common malignancy among women globally. Thus, there is a continuous need to search for chemotherapeutic chemicals or naturally occurring drugs to resolve this global health problem. Piperine (1-piperoylpeperdine) is present in the fruits of black pepper (Piper nigrum Linn.) and long pepper (Piper longum Linn.). It possesses several pharmacological properties and in the present study we have evaluated its anti-cancer potential on human cervical adenocarcinoma (HeLa) cells.

Methods: The anti-proliferative effect …

Development And Evaluation Of A Nanofiber Membrane In Vitro As A Therapeutic Alternative For The Post Treatment In Breast Cancer Cell In A Murine Model, Bruno A. Valades-Aguilar, Diana Ginette Zarate-Triviño, José Raúl Rángel-López, Moises Armides Franco-Molina, Jorge Luis Menchaca-Arredondo, María Cristina Rodríguez-Padilla

Research Symposium

Worldwide female breast cancer is the most commonly diagnosed cancer, with an estimated 2.3 million new cases in 2020, reason for the need of targeted therapies that can maximize treatment success and minimize toxicity. Nanoparticles of gold (AuNps) exhibit cytotoxic properties against certain types of cancer cell lines. Nanofibers have been use in the drug delivery systems due to its degradability and high surface area. We proposed a membrane with nanometric fibers using polivinilic alcohol (PVA) and chitosan (Qts) loaded with AuNps and Doxorubicin (Doxo) with the purpose of diminish tumor regression.

PVA-Qts membrane was develop with electrospinning, the injection, …

Mucocele Of Lower Lip Treated With Constitutional Homoeopathic Medicine Silicea – A Case Report, Uma Maheswari M.S, Sisir P R, Gopukumar S T

Indian Journal of Research in Homoeopathy

Introduction: A mucocele is a mucus-containing benign cystic lesion of the salivary gland. Based on the histological features, they are classified into two types, mucous retention cysts and mucous extravasation cysts. They appear in the minor salivary glands due to mechanical damage to the gland or its duct. The case study presented here is a detailed analysis of a 6-year-old male child affected by mucocele of the lower lip and its homoeopathic treatment and significance. Case Summary: A 6-year-old child presented with complaint of a swelling over the mucosa of the lower lip. Initially, the swelling was small, …

Individualised Homoeopathic Medicine Versus Placebo In The Pain Management Of Knee And Hip Osteoarthritis: A Double-Blind, Randomised Controlled Trial, Azizul Islam Khadim, Vivek Kumar Shail, Kanak Kumar, Sabiha Naaz, Abhijit Chakma

Indian Journal of Research in Homoeopathy

Background: Osteoarthritis (OA) is a progressive, degenerative disease affecting large weight-bearing joints. The severity of symptoms varies among individuals; whereas pain and stiffness are the most troublesome complaints. Homoeopathic medicines have the potential to manage pain episodes. Objective: The aim of the study was to assess the effect of individualised homoeopathic medicine (IHM) in managing the pain of knee and hip OA. Methods: A prospective, double-blind, randomised (1:1) placebo-controlled trial was conducted on 60 individuals suffering from OA at R.B.T.S. Govt. Homoeopathic Medical College and Hospital, Muzaffarpur. Visual analogue scale for pain (Score-A-1), stiffness (Score-A-2) and loss …

Homoeopathic Management Of Non-Responsive, Nodulocystic Acne: A Case Report, Padmalaya Rath, Indu Shukla

Indian Journal of Research in Homoeopathy

Introduction: Nodulocystic acne is a severe form of acne that can significantly damage the skin and impact the quality of life. Although oral isotretinoin is considered an effective conventional treatment for such cases, it often fails. A case of severe facial nodulocystic acne is reported here, where allopathic treatment failed to control the condition. Homoeopathic treatment was administered, and the patient improved. Case Summary: A 16-year-old female patient presented with pustular, nodular, cystic and painful eruptions on the face, which were treated with individualised homoeopathic medicine Tarentula cubensis. The symptoms improved without any relapse. The causal attribution of …

Tinea Cruris Treated With Individualised Homoeopathic Medicine – An Evidence-Based Case Report, Yogeshwari Gupta, Arvind Sharma, Samridhi Sharma

Indian Journal of Research in Homoeopathy

Introduction: Tinea cruris, also commonly known as jock itch, is a skin infection caused by dermatophytes which are pathogenic fungi affecting genital, pubic, perineal and perianal areas. Tinea cruris more commonly affects men and affects adults more than children. Conventional management involves the use of topical antifungal agents and oral therapy in extensive cases. Case Summary: A case of tinea cruris in a 30-year-old male patient is reported, which was effectively treated with individualised homoeopathic medicine. Based on the totality of symptoms, the homoeopathic medicine Natrum muriaticum in 200C potency was prescribed as the first dose and improvement …

Effectiveness Of Individualised Homoeopathic Intervention In Warts – A Case Series, Dastagiri P, Chakravarthy S.G.S, Renu Mittal

Indian Journal of Research in Homoeopathy

Verruca vulgaris, also known as common warts, is benign lesions caused by the non-malignant human papillomavirus, affecting approximately 10% of the population globally. It may range from 1 mm to several cm, and are mostly seen on the extremities, followed by the face. They may be transmitted by direct or indirect contact and lead to cosmetic concerns, itching and mild to severe pain while doing activities. Conventional treatment has destructive therapies such as salicylic acid, cauterisation and cryosurgery, which induce many adverse effects from local to general. However, an individualised homoeopathic approach can be used to effectively treat these warts, …

Physicochemical Standardisation Of The Homoeopathic Drug, Apis Mellifica: A Preliminary Attempt, Bibaswan Biswas, Satyajit Maity, En Sundaram, Gv Narasimha Kumar, Satish Patel

Indian Journal of Research in Homoeopathy

Background: Unlike the mainstream biomedical system, honeybees’ therapeutic use has long been well documented in the homoeopathic system. The medicine prepared from the whole honeybee, Apis mellifica, is on the Essential Drug List. Objective: An in-depth physicochemical standardisation of this homoeopathic drug is attempted. Material and Methods: In this study, first the raw drug was authenticated, and then its pharmacopoeial parameters were measured, e.g. moisture content, foreign matter, different ash values, alcohol and water-soluble extractive values. Further, the mother tincture of Apis mellifica was prepared from the authentic raw drug. The pharmacopeial parameters of in-house mother tincture …

Homoeopathic Medicines Modulate Inflammatory Functions And Adhesion Receptor Expression In Human Blood Cells: An In Vitro Study, Nibedita Dalpati, Shubham Kumar Rai, Divya Singh, Shiba Prasad Dash, Sukanti S. Sarangi, Mahabahu Nayak, Pranita P. Sarangi

Indian Journal of Research in Homoeopathy

Background: Homoeopathic medicines are used extensively for the treatment of many human diseases and are shown to affect immune cell functions. However, our understanding of the immunomodulatory effects of such medicines and associated mechanisms of action remains limited. Objectives: The present study aims to investigate the immunomodulatory effects of Arsenic album, Rhus toxicodendron, Hepar sulphuris and Bryonia alba on lipopolysaccharide (LPS) induced peripheral blood neutrophils and monocytes. Materials and Methods: In this work, neutrophils and monocytes were treated with different homoeopathic dilutions of 30C potency separately, followed by stimulation with the LPS, to examine the immunomodulatory effects of these …