Circulating Exosomal Microrna Expression Patterns Distinguish Cardiac Sarcoidosis From Myocardial Ischemia., 2021 Institute for Systems Biology, Seattle, Washington, United States of America
Circulating Exosomal Microrna Expression Patterns Distinguish Cardiac Sarcoidosis From Myocardial Ischemia., Elliott D Crouser, Mark W Julian, Sabahattin Bicer, Vikas Ghai, Taek-Kyun Kim, Lisa A Maier, May Gillespie, Nabeel Y Hamzeh, Kai Wang
Articles, Abstracts, and Reports
OBJECTIVE: Cardiac sarcoidosis is difficult to diagnose, often requiring expensive and inconvenient advanced imaging techniques. Circulating exosomes contain genetic material, such as microRNA (miRNA), that are derived from diseased tissues and may serve as potential disease-specific biomarkers. We thus sought to determine whether circulating exosome-derived miRNA expression patterns would distinguish cardiac sarcoidosis (CS) from acute myocardial infarction (AMI).
METHODS: Plasma and serum samples conforming to CS, AMI or disease-free controls were procured from the Biologic Specimen and Data Repository Information Coordinating Center repository and National Jewish Health. Next generation sequencing (NGS) was performed on exosome-derived total RNA (n = 10 …
Mathematical Modeling Of Lung Inflammation: Macrophage Polarization And Ventilator-Induced Lung Injury With Methods For Predicting Outcome, 2021 Virginia Commonwealth University
Mathematical Modeling Of Lung Inflammation: Macrophage Polarization And Ventilator-Induced Lung Injury With Methods For Predicting Outcome, Sarah B. Minucci
Theses and Dissertations
Lung insults, such as respiratory infections and lung injuries, can damage the pulmonary epithelium, with the most severe cases needing mechanical ventilation for effective breathing and survival. Furthermore, despite the benefits of mechanical ventilators, prolonged or misuse of ventilators may lead to ventilation-associated/ventilation-induced lung injury (VILI). Damaged epithelial cells within the alveoli trigger a local immune response. A key immune cell is the macrophage, which can differentiate into a spectrum of phenotypes ranging from pro- to anti-inflammatory. To gain a greater understanding of the mechanisms of the immune response in the lungs and possible outcomes, we developed several mathematical models …
Evaluating Common Raven Take For Greater Sage-Grouse In Oregon’S Baker County Priority Conservation Area And Great Basin Region, 2021 U.S. Fish and Wildlife Service
Evaluating Common Raven Take For Greater Sage-Grouse In Oregon’S Baker County Priority Conservation Area And Great Basin Region, Frank F. Rivera-Milán, Peter S. Coates, Jacqueline B. Cupples, Michael Green, Patrick K. Devers
Human–Wildlife Interactions
The common raven (Corvus corax; raven) is a nest predator of species of conservation concern, such as the greater sage-grouse (Centrocercus urophasianus). Reducing raven abundance by take requires authorization under the Migratory Bird Treaty Act. To support U.S. Fish and Wildlife Service’s take decisions (e.g., those that authorize killing a specified proportion or number of individuals annually in a defined area), including the most recent one for Oregon’s Baker County Priority Area for Conservation (PAC), we modeled raven population dynamics under hypothetical scenarios with take rates ranging from below to above the maximum sustained yield (MSY; …
Of Biodiversity, Boundaries, And Distribution: The Myxomycetes Of The Philippines And Beyond, 2021 University of Arkansas, Fayetteville
Of Biodiversity, Boundaries, And Distribution: The Myxomycetes Of The Philippines And Beyond, Sittie Aisha Bustamante Macabago
Graduate Theses and Dissertations
This dissertation contains a compilation of independently performed studies primarily focusing on the myxomycetes (plasmodial slime molds) from the Philippines and integrating local and worldwide data to demonstrate regional and global trends. The major themes include the following: (I) a review of the diverse group of spore-producing amoeboid protists, including the myxomycetes; (II-IV) diversity assessments in three different groups of islands in the Philippine archipelago; (V) mapping the myxomycetes found in the Philippines for databasing and analyzing the geocoded data; (VI) a study on regional boundaries, including the Philippines, using myxomycete species composition; and, (VII) creating a global species distribution …
Status Reports Of The Fisheries And Aquatic Resources Of Western Australia 2020/21, 2021 Department of Primary Industries and Regional Development, Western Australia
Status Reports Of The Fisheries And Aquatic Resources Of Western Australia 2020/21, S.J. Newman, B.S. Wise, K.G. Santoro, D.J. Gaughan
Status reports of the fisheries and aquatic resources
The Status Reports of the Fisheries and Aquatic Resources of Western Australia (SRFAR) provide an annual update on the state of the fish stocks and other aquatic resources of Western Australia (WA). These reports outline the most recent assessments of the cumulative risk status for each of the aquatic resources (assets) within WA’s six Bioregions using an Ecosystem Based Fisheries Management (EBFM) approach. The Departments’ risk based EBFM framework is the State government’s basis for management of all Western Australia’s aquatic resources.
Effects Of 4-Methylcyclohexanemethanol On Stress Response Pathway Regulators, In Saccharomyces Cerevisiae, 2021 West Virginia University
Effects Of 4-Methylcyclohexanemethanol On Stress Response Pathway Regulators, In Saccharomyces Cerevisiae, Suk Lan Ser
Graduate Theses, Dissertations, and Problem Reports
Hydrotropes are small molecules capable of inducing liquid-liquid phase separation by altering the solubility and conformation states of organic compounds that are increasingly becoming important in organizing chemical reactions and regulating complexes. They prevent protein aggregation causing these proteins to form condensates. Mediator, a highly conserved multi-subunit complex, plays an important role in transcription. Med15, a subunit found within the tail domain of the Mediator complex, works with stress-induced transcription factors and is regulated by many kinases, including CDKs and the AMP kinase, Snf1. Living cells respond by changing molecular and cellular pathways when they are exposed to stressful conditions. …
Nitrogen Dynamics And Transport Along Flowpaths In A Rural Wetland-Stream Complex, 2021 University of Montana
Nitrogen Dynamics And Transport Along Flowpaths In A Rural Wetland-Stream Complex, Colton Kyro
Graduate Student Theses, Dissertations, & Professional Papers
Human activities have doubled the rate of nitrogen inputs onto the landscape resulting in elevated nitrogen concentrations in our streams. Anthropogenically applied nitrogen is largely transported to stream networks via groundwater movement. Groundwater discharge occurs in distinct points along a stream but whose influences can often persist far beyond that area due to insufficient biogeochemical removal of imported nitrogen potentially causing alterations in community structure and precipitating large algae blooms. To understand the factors governing nitrogen abundance in a historical polluted stream, I used a mass-balance approach to quantify groundwater-surface water interaction and the magnitude of groundwater nitrogen input and …
Phylogeography, Diversification, And Historical Demography Of The White-Toothed Rats (Berylmys) In Indochina, 2021 Northern Illinois University
Phylogeography, Diversification, And Historical Demography Of The White-Toothed Rats (Berylmys) In Indochina, Kristy Lee Tuttle
Graduate Research Theses & Dissertations
Berylmys, the White-toothed rats, and other members of the Rattus sl (Rattus, Maxomys, Leopoldamys, Niviventer, Bandicota, and Sundamys) evolved from 3-5 million years ago during a period of dynamic landscape change in Indochinese south Asia wherein climatically stable, warm forests of Miocene and Pliocene Indochina transitioned to a modern landscape regime. From the late Pliocene through the terminal Pleistocene, climate changes, ecological shifts, rising and falling sea levels, and tectonic uplift drove adaptive radiation within Rattus sl, in complex interactions that are still not completely understood. The goal of this study is to understand species relationships and population structure in …
Comparison Of Standard And Environmental Dna Methods For Estimating Chinook Salmon Smolt Abundance In The Klamath River, California, 2021 Cal Poly Humboldt
Comparison Of Standard And Environmental Dna Methods For Estimating Chinook Salmon Smolt Abundance In The Klamath River, California, Doyle Joseph Coyne
Cal Poly Humboldt theses and projects
Evaluating abundance of juvenile salmonids is critical to conservation and management. Current abundance estimation involves use of rotary screw traps and mark-recapture studies. Use of environmental DNA (eDNA) in water samples offers a noninvasive and less expensive approach that may potentially improve or eventually replace traditional monitoring. Here I evaluate the utility of eDNA to predict weekly abundance estimates of outmigrating Chinook salmon (Oncorhynchus tshawytscha) smolts in the Klamath River, California. A total of 15 water samples were collected per week over the 17-week smolt outmigration in both 2019 and 2020. Chinook salmon eDNA concentration in each water …
The Mayfly Newsletter, 2020 Southwestern Oklahoma State University
The Mayfly Newsletter, Donna Giberson, Peter M. Grant
The Mayfly Newsletter
The Mayfly Newsletter is the official newsletter of the Permanent Committee of the International Conferences on Ephemeroptera.
The Prairie Naturalist, Vol. 52, Issue 2, December 2020, 2020 University of Nebraska - Lincoln
The Prairie Naturalist, Vol. 52, Issue 2, December 2020
The Prairie Naturalist
Comparing Native Bee Communities on Reconstructed and Remnant Prairie in Missouri • Joseph LaRose, Elisabeth B. Webb, and Deborah Finke
Patterns and Potential Causes of Changing Winter Bird Distributions in South Dakota • David L. Swanson, Reza Goljani Amipkhiz, and Mark D. Dixon
Greater prairie-chickens and sharp-tailed grouse have similarly high nest survival in the Nebraska Sandhills • Larkin A. Powell, Walter H. Schacht, Julia P. Ewalt, and Katie R. McCollum
Captive Ring-necked Pheasant Response to Very High Experimental Doses of Lead • Travis J. Runia and Alex J. Solem
Trends in a Greater Prairie Chicken Population Established by Translocation …
Investigation Of Proliferation Suppressors In Genetic Fitness Screens, 2020 The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences
Investigation Of Proliferation Suppressors In Genetic Fitness Screens, Walter Frank Lenoir Iv
Dissertations & Theses (Open Access)
Innovation of CRISPR gene-editing technology has provided scientists genome manipulation tools that allowed rapid advancement of scientific capabilities and thus improved our ability to systematically study mammalian genetic functional profiles. Genome-wide CRISPR knockout screens conducted in collections of human cell lines can knock out genes at multiple loci, and have provided new insights into functional roles for independent genes. This method has launched massive efforts in looking across genetic backgrounds for context specific genetic vulnerabilities within cancer. Much of the research effort thus far has been spent on optimizing phenotype distinctions between essential, genes required for cell fitness, and non-essential, …
A Context-Forward In Vivo Functional Genomics Platform For Target Discovery And Establishing Vulnerability Context In Pancreatic Cancer, 2020 The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences
A Context-Forward In Vivo Functional Genomics Platform For Target Discovery And Establishing Vulnerability Context In Pancreatic Cancer, Johnathon Rose, Johnathon Lynn Rose
Dissertations & Theses (Open Access)
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a very poor patient prognosis (5-year survival of ≤ 7%). While transcriptional profiling has aided in the classification of this disease into at least two broader subtypes, this alone has so far been insufficient to inform on more nuanced patterns of oncogenic dependency. We hypothesized that a more comprehensive and granular characterization of PDAC disease diversity is required to establish relevant context for targeted therapy. To this end, we sought to establish an integrated platform to: i) more comprehensively characterize differential oncogenic signaling across our tumor models, and ii) establish …
Molecular Mechanisms Of Boron Toxicity Tolerance In Plants, 2020 Louisiana State University and Agricultural and Mechanical College
Molecular Mechanisms Of Boron Toxicity Tolerance In Plants, Guannan Wang
LSU Doctoral Dissertations
Boron toxicity is a worldwide agricultural problem that limits crop productivity and quality. However, our understanding on the genetic responses and adaption mechanisms to boron toxicity in plants is very limited. To address this gap in our knowledge, I compared boron stress-sensitive model, Arabidopsis thaliana and its stress-adapted relative Schrenkiella parvula to study how plants respond and adapt to excess boron at physiological, genomic, transcriptomic, and metabolic levels.
The overall project goal involved integration of multi-omics datasets to develop genome to phenome interpretations. To achieve this, I developed a python package, GOMCL, to facilitate the extraction of biologically meaningful information …
Estimating The Number Of Discrete Models Of Biological Networks, 2020 Southern Methodist University
Estimating The Number Of Discrete Models Of Biological Networks, Brandilyn Stigler
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Mathematical Modelling And In Silico Experimentation To Estimate The Quantity Of Covid-19 Infected Individuals In Tijuana, México, 2020 Tijuana Institute of Technology, México
Mathematical Modelling And In Silico Experimentation To Estimate The Quantity Of Covid-19 Infected Individuals In Tijuana, México, Karla A. Encinas, Luis N. Coria, Paul A. Valle
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Wnt Signaling Determines Body Axis Polarity In Regenerating Hydra Tissue Fragments, 2020 Swarthmore College
Wnt Signaling Determines Body Axis Polarity In Regenerating Hydra Tissue Fragments, R. Wang, R. E. Steele, Eva-Maria S. Collins
Biology Faculty Works
How an animal establishes its body axis is a fundamental question in developmental biology. The freshwater cnidarian Hydra is an attractive model for studying axis formation because it is radially symmetric, with a single oral-aboral axis. It was recently proposed that the orientation of the new body axis in a regenerating Hydra polyp is determined by the oral-aboral orientation of the actin-myosin contractile processes (myonemes) in the animal’s outer epithelial layer. However, it remained unclear how the oral-aboral polarity of the body axis would be defined. As Wnt signaling is known to control axis polarity in Hydra and bilaterians, we …
Molecular Identification And Characterization Of Viral Pathogens Infecting Sweet Cherry, 2020 The University of Western Ontario
Molecular Identification And Characterization Of Viral Pathogens Infecting Sweet Cherry, Aaron J. Simkovich
Electronic Thesis and Dissertation Repository
Stone fruits are a valuable crop grown worldwide, however pathogens such as viruses threaten fruit production by reducing tree health and fruit yield. In an orchard within the Niagara region of Ontario, symptoms typical of viral infection such as chlorosis and leaf deformation were seen on sweet cherry (Prunus avium L.) trees. Next generation sequencing was performed on symptomatic and asymptomatic leaves and four viruses were identified. On the tree displaying the most severe symptoms, Prune dwarf virus (PDV), was the only virus detected. A survey conducted during this work showed 42% of cherry trees on a single …
Homicide And Drug Trafficking In Impoverished Communities In Brazil, 2020 Montclair State University
Homicide And Drug Trafficking In Impoverished Communities In Brazil, Elenice De Souza De Souza Oliveira, Braulio Figueiredo Alves Da Silva, Flavio Luiz Sapori, Gabriela Gomes Cardoso
Department of Justice Studies Faculty Scholarship and Creative Works
Many studies demonstrate that homicides are heavily concentrated in impoverished neighborhoods, but not all socially disadvantaged neighborhoods are hotbeds of violence. Conducted in Belo Horizonte, Brazil, this study hypothesizes that the association between high rates of homicide and impoverished areas is influenced by the emergence of a specific type of street drug-dealing common to favelas (slums). The study applies econometric techniques to police data on homicides and drug arrests from 2008 to 2011, as well as 2010 Census data, to test its hypothesis. The findings provide insight into the development of crime prevention policies in areas of high social vulnerability.
Machine Learning Applications For Drug Repurposing, 2020 The Graduate Center, City University of New York
Machine Learning Applications For Drug Repurposing, Hansaim Lim
Dissertations, Theses, and Capstone Projects
The cost of bringing a drug to market is astounding and the failure rate is intimidating. Drug discovery has been of limited success under the conventional reductionist model of one-drug-one-gene-one-disease paradigm, where a single disease-associated gene is identified and a molecular binder to the specific target is subsequently designed. Under the simplistic paradigm of drug discovery, a drug molecule is assumed to interact only with the intended on-target. However, small molecular drugs often interact with multiple targets, and those off-target interactions are not considered under the conventional paradigm. As a result, drug-induced side effects and adverse reactions are often neglected …