Atomistic Simulations And In Silico Mutational Profiling Of Protein Stability And Binding In The Sars-Cov-2 Spike Protein Complexes With Nanobodies: Molecular Determinants Of Mutational Escape Mechanisms,
2021
Chapman University
Atomistic Simulations And In Silico Mutational Profiling Of Protein Stability And Binding In The Sars-Cov-2 Spike Protein Complexes With Nanobodies: Molecular Determinants Of Mutational Escape Mechanisms, Gennady M. Verkhivker, Steve Agajanian, Deniz Yasar Oztas, Grace Gupta
Mathematics, Physics, and Computer Science Faculty Articles and Research
Structure-functional studies have recently revealed a spectrum of diverse high-affinity nanobodies with efficient neutralizing capacity against SARS-CoV-2 virus and resilience against mutational escape. In this study, we combine atomistic simulations with the ensemble-based mutational profiling of binding for the SARS-CoV-2 S-RBD complexes with a wide range of nanobodies to identify dynamic and binding affinity fingerprints and characterize the energetic determinants of nanobody-escaping mutations. Using an in silico mutational profiling approach for probing the protein stability and binding, we examine dynamics and energetics of the SARS-CoV-2 complexes with single nanobodies Nb6 and Nb20, VHH E, a pair combination VHH E + …
Ua94/6/1 Pandemic Personal Narrative,
2021
Western Kentucky University
Ua94/6/1 Pandemic Personal Narrative, Leah Painter
Student/Alumni Personal Papers
COVID-19 personal narrative written by student Leah Painter for History 241 class.
Life In A Pandemic,
2021
Sacred Heart University
Life In A Pandemic, Francesco Anonymous
Community Reflections
Class assignment for Western Civilization. My family and I were some of the unfortunate ones as covid affected us considerably. Family members and close friends that were dear to us became sick, and some even passed. My mother's occupation was stolen from her, too, due to the circumstances. These events as a whole left us emotionally and financially damaged.
Covid-19,
2021
Sacred Heart University
Covid-19, Anonymous
Community Reflections
Class assignment for Western Civilization , HI-102. For me, the only word to describe the pandemic was horrifying. Anyone who had any recollection of the pandemic will say March 13th will forever live in their memory as the day the world changed.
Western Civilization Primary Source Reflection #1,
2021
Sacred Heart University
Western Civilization Primary Source Reflection #1, Anonymous
Community Reflections
The virus made it to Australia, and eventually, we followed suit and went into a nationwide lockdown.
The Covid-19 Pandemic Changed The World,
2021
Sacred Heart University
The Covid-19 Pandemic Changed The World, Anonymous
Community Reflections
What I most want people in the future to understand about the COVID-19 pandemic is how quickly it changed from what everyone thought was a small sickness, into a worldwide pandemic that led to a complete shutdown.
Covid-19, The Coronavirus: It Has Many Names,
2021
Sacred Heart University
Covid-19, The Coronavirus: It Has Many Names, Anonymous
Community Reflections
Class assignment for Western Civilization. A lot of people died, businesses shut down, people had to learn or work at home and students had school online using apps like zoom to participate in class in real time because of the whole nation quarantining itself. Quarantining was probably the worst and yet not the worst part of Covid because no one was able to go anywhere, everyone had to stay home so no hanging out with friends or really any kind of socialization.
Primary Source Reflection #1,
2021
Sacred Heart University
Primary Source Reflection #1, Anonymous
Community Reflections
Class assignment for Western Civilization. During the time of the pandemic it was a hard time for me because of the new challenges we would have to go through as a country together. the new way of life by having to wear masks, being socially distant from others, and having online learning were just the tip of the iceberg of the pandemic. March 13th 2020 was the last day of in person learning for my junior year and high school and ever since then life took a complete different turn with dealing with the pandemic.
Primary Source Reflection #1,
2021
Sacred Heart University
Primary Source Reflection #1, Brennan Anonymous
Community Reflections
Class assignment for Western Civilization. At this point in time, our generation is still currently living through COVID-19.
Worst 6 Months Of My Life,
2021
Sacred Heart University
Worst 6 Months Of My Life, Nicholas Anonymous
Community Reflections
Class assignment for Western Civilization.
Self-Growth And Self-Reflection,
2021
Sacred Heart University
Self-Growth And Self-Reflection, Anonymous
Community Reflections
Professor Marino assignment, reflection of my own personal experiences during the COVID-19 pandemic, and I would want future generations to know about what life during the COVID pandemic was like.
A Different Outlook,
2021
Sacred Heart University
A Different Outlook, Anonymous
Community Reflections
Class assignment for Western Civilization. No matter how hard the quarantine phase of the COVID-19 pandemic got we were always grateful for what we had.
Probing The Pandemic Problem,
2021
Sacred Heart University
Probing The Pandemic Problem, Anonymous
Community Reflections
Class assignment for Western Civilization. I struggled to sustain the same love for learning.
Quarantine Wasn't As It Seemed,
2021
Sacred Heart University
Quarantine Wasn't As It Seemed, Anonymous
Community Reflections
Class assignment for Western Civilization. My paper describes my experience over quarantine. It mentions my adjustment to the crisis.
Exploring Digital Health Interventions To Support Community Health Workers In Low-And-Middle-Income Countries During The Covid-19 Pandemic: A Scoping Review Protocol,
2021
Aga Khan University
Exploring Digital Health Interventions To Support Community Health Workers In Low-And-Middle-Income Countries During The Covid-19 Pandemic: A Scoping Review Protocol, Anam Shahil Feroz, Komal Valliani, Hajra Khwaja, Sehrish Karim
Community Health Sciences
Introduction: COVID-19 has significantly affected community health workers' (CHWs) performance as they are expected to perform pandemic-related tasks along with routine essential healthcare services. A plausible way to optimise CHWs' functioning during this pandemic is to couple the efforts of CHWs with digital tools. So far, no systematic evidence is available on the use of digital health interventions to support CHWs in low-middle-income countries (LMICs) amid the COVID-19 pandemic. The article describes a protocol for a scoping review of primary research studies that aim to map evidence on the use of unique digital health interventions to support CHWs during COVID-19 …
Human-Machine Communication: Complete Volume. Volume 3. Diffusion Of Human-Machine Communication During And After The Covid-19 Pandemic,
2021
University of Central Florida
Human-Machine Communication: Complete Volume. Volume 3. Diffusion Of Human-Machine Communication During And After The Covid-19 Pandemic
Human-Machine Communication
This is the complete volume of HMC Volume 3. Diffusion of Human-Machine Communication During and After the COVID-19 Pandemic
The Role Of Vidura Chatbot In The Diffusion Of Knowcovid-19 Gateway,
2021
Texas Tech University
The Role Of Vidura Chatbot In The Diffusion Of Knowcovid-19 Gateway, Kerk F. Kee, Prasad P. Calyam, Hariharan Regunath
Human-Machine Communication
The COVID-19 pandemic is an unprecedented global emergency. Clinicians and medical researchers are suddenly thrown into a situation where they need to keep up with the latest and best evidence for decision-making at work in order to save lives and develop solutions for COVID-19 treatments and preventions. However, a challenge is the overwhelming numbers of online publications with a wide range of quality. We explain a science gateway platform designed to help users to filter the overwhelming amount of literature efficiently (with speed) and effectively (with quality), to find answers to their scientific questions. It is equipped with a chatbot …
The World Flipped Upside Down,
2021
Sacred Heart University
The World Flipped Upside Down, Alexander Anonymous
Community Reflections
Class assignment for Western Civilization. My paper relates my experience of the COVID-19 pandemic, and how quickly it can flip the world upside down. The story takes place in Fairfield County, CT in 2020.
An Unexpected Curveball,
2021
Sacred Heart University
An Unexpected Curveball, Anonymous
Community Reflections
Class assignment for Western Civilization. Covid-19 impacted our lives in a very direct and prolonged way. The isolation and feelings of detachment due to stay at home orders, social distancing, and mask wearing affected a large part of the population.
Spoiler Alert: It Got Really Bad,
2021
Sacred Heart University
Spoiler Alert: It Got Really Bad, Anonymous
Community Reflections
Class assignment for Western Civilization. This is about my personal experience with COVID-19 and all of the different adjustments not only I had to make in my day-to-day, but that everyone had to make. It affected my high school experience and is now affecting (not as much so) my college experience.
