Life Sciences Commons^™

Omega-6 And Omega-3 Fatty Acid-Derived Oxylipins From The Lipoxygenase Pathway In Maternal And Umbilical Cord Plasma At Delivery And Their Relationship With Infant Growth, Maranda Thompson, Arzu Ulu, Ana G. Yuil-Valdes, Maheswari Mukherjee, Melissa K. Thoene, Matthew Van Ormer, Rebecca Slotkowski, Elizabeth Lyden, Ann Anderson-Berry, Corrine K. Hanson, Tara M. Nordgren, Sathish Kumar Natarajan

Department of Nutrition and Health Sciences: Faculty Publications

Omega-3 and omega-6 fatty acids are important for neonatal development and health. One mechanism by which omega-3 and omega-6 fatty acids exert their effects is through their metabolism into oxylipins and specialized pro-resolving mediators. However, the influence of oxylipins on fetal growth is not well understood. Therefore, the objective of this study was to identify oxylipins present in maternal and umbilical cord plasma and investigate their relationship with infant growth. Liquid chromatography–tandem mass spectrometry was used to quantify oxylipin levels in plasma collected at the time of delivery. Spearman’s correlations highlighted significant correlations between metabolite levels and infant growth. They …

Smokejumper Obituary: Desautel, Ryan Ray (Grangeville 2004), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Evolutionary Analyses Of Visual Opsin Genes In Frogs And Toads: Diversity, Duplication, And Positive Selection, Ryan K. Schott, Leah Perez, Matthew Kwiatkowski, Vance Imhoff, Jennifer M. Gumm

Faculty Publications

Among major vertebrate groups, anurans (frogs and toads) are understudied with regard to their visual systems, and little is known about variation among species that differ in ecology. We sampled North American anurans representing diverse evolutionary and life histories that likely possess visual systems adapted to meet different ecological needs. Using standard molecular techniques, visual opsin genes, which encode the protein component of visual pigments, were obtained from anuran retinas. Additionally, we extracted the visual opsins from publicly available genome and transcriptome assemblies, further increasing the phylogenetic and ecological diversity of our dataset to 33 species in total. We found …

Light-Driven Dynamics Between Calcification And Production In Functionally Diverse Coral Reef Calcifiers, Jennifer Mallon, Tyler Cyronak, Emily R. Hall, Anastazia T. Banaszak, Dan A. Exton, Adrian M. Bass

Marine & Environmental Sciences Faculty Articles

Coral reef metabolism underpins ecosystem function and is defined by the processes of photosynthesis, respiration, calcification, and calcium carbonate dissolution. However, the relationships between these physiological processes at the organismal level and their interactions with light remain unclear. We examined metabolic rates across a range of photosynthesising calcifiers in the Caribbean: the scleractinian corals Acropora cervicornis, Orbicella faveolata, Porites astreoides, and Siderastrea siderea, and crustose coralline algae (CCA) under varying natural light conditions. Net photosynthesis and calcification showed a parabolic response to light across all species, with differences among massive corals, branching corals, and CCA that …

Transforming Science Into Practice, Janice Jiggins

IGC Proceedings (1977-2023)

The space for action that might move agricultural systems toward sustainability is narrowing. In so far as increasing dis-order in agroecosystems and food systems is caused by human agency, then remedial action must take account of cognition. This article argues that an understanding of cognitive processes is essential, as the foundation for participatory R, D & E that builds platforms of cooperation, binding actors into communities of learning that are trasnforming both science and practice.

Technology Transfer And Education Training And Extension In Grassland Farming, K. G. Rickert

IGC Proceedings (1977-2023)

Stakeholders in grassland farming, including farmers, rural communities, urban consumers, politicians, educators, and service agencies, widely agree that the goal for grassland farming is the triple bottom line: farming systems that are ecologically sustainable, profitable and socially acceptable. This paper considers how extension and training might contribute to that worthy goal by encouraging practitioners to better manage their management environment. The notion of a management environment refers to a holistic consideration of those factors that impact on farmers, farm advisors or educators, that subset of grassland farming ‘practitioners’ within the wider range of stakeholders.

The difficulty faced by these practitioners …

Gis-Based Forage Species Adaptation Mapping, David B. Hannaway, C. Daly, W. Gibson, G. Taylor, J. P. Bolte, I. Sriprisan, T. Griggs

IGC Proceedings (1977-2023)

Selecting forage crops adapted to the climatic and edaphic conditions of specific locations is essential for economic sustainability and environmental protection. Yet, currently, proper selection is difficult due to the absence of advanced selection tools. Significant improvements are being made in the process through Geographic Information System (GIS)-based mapping. Climate and soil GIS layers are being matched with forage characteristics through rules describing species tolerances. Better matching will reduce economic risks and environmental hazards associated with sub-optimal crop selection and subsequent performance. Once developed, these forage crop selection strategies and tools can be adapted for use with other crops. A …

On Farm Riparian Grazing Demonstration, J. T. Green Jr., M. H. Poore, S. P. Morgan

IGC Proceedings (1977-2023)

Two farm demonstrations were designed to show effects of periodic grazing of riparian areas. Sites were monitored for vegetative cover, degree of treading or hoof prints and dung deposition within three m of stream edge following grazing by beef cattle. A fenced enclosure was established along a 350 m stream reach on Farm-1, and eleven permanent stations were monitored following six graze periods over 12-months. Farm-2 involved grazing of two 0.13 ha paddocks, each of which contained a 22 m stream reach. On Farm-1 the cover improved following riparian exclusion, and evidence of treading in the 11 stations declined following …

A New Window Into Children's Memory: Professor Of Psychology Martha Arterberry's New Study Comes With Implications For Eyewitness Testimonies, Kardelen Koldas

Colby Magazine

When children are eyewitnesses—to an incident, an accident, or a crime— does age matter? Are older kids more precise in recounting an event than the younger ones?

Rapid Response: Cat-Scan Machine And 3d Printers Vital In Covid-19, Laura Meader

Colby Magazine

Colby’s Assistant Professor of Biology Josh Martin is using his expertise and sophisticated scientific equipment to create face shields, respirator masks, and air filter cartridges for local first responders and hospitals in need of equipment that is crucial to treating patients with COVID-19.

The Human Disease Ontology 2022 Update., Lynn M Schriml, James B Munro, Mike Schor, Dustin Olley, Carrie Mccracken, Victor Felix, J Allen Baron, Rebecca Jackson, Susan M. Bello, Cynthia Bearer, Richard Lichenstein, Katharine Bisordi, Nicole Campion Dialo, Michelle Giglio, Carol Greene

Faculty Research 2022

The Human Disease Ontology (DO) (www.disease-ontology.org) database, has significantly expanded the disease content and enhanced our userbase and website since the DO's 2018 Nucleic Acids Research DATABASE issue paper. Conservatively, based on available resource statistics, terms from the DO have been annotated to over 1.5 million biomedical data elements and citations, a 10× increase in the past 5 years. The DO, funded as a NHGRI Genomic Resource, plays a key role in disease knowledge organization, representation, and standardization, serving as a reference framework for multiscale biomedical data integration and analysis across thousands of clinical, biomedical and computational research projects and …

Loss-Of-Function Mutation In Pcsk1 Increases Serum Apoa1 Level And Lcat Activity In Mice., Aleksandra Aljakna Khan, Nakyung Kim, Ron Korstanje, Seungbum Choi

Faculty Research 2022

BACKGROUND: The convertase subtilisin/kexin family 1 gene (PCSK1) has been associated in various human genetics studies with a wide spectrum of metabolic phenotypes, including early-onset obesity, hyperphagia, diabetes insipidus, and others. Despite the evident influence of PCSK1 on obesity and the known functions of other PCSKs in lipid metabolism, the role of PCSK1 specifically in lipid and cholesterol metabolism remains unclear. This study evaluated the effect of loss of PCSK1 function on high-density lipoprotein (HDL) metabolism in mice.

RESULTS: HDL cholesterol, apolipoprotein A1 (APOA1) levels in serum and liver, and the activities of two enzymes (lecithin-cholesterol acyltransferase, LCAT and phospholipid …

Plant Canopy May Promote Seed Dispersal By Wind, Xuanping Qin, Wei Liang, Zhimin Liu, Minghu Liu, Carol C. Baskin, Jerry M. Baskin, Zhiming Xin, Zhigang Wang, Quanlai Zhou

Biology Faculty Publications

Seed dispersal has received much research attention. The plant canopy can intercept diaspores, but the effect of the plant canopy (the aboveground portion of a plant consisting of branches and leaves) on dispersal distance has not been explored empirically. To determine the effect of plant canopy on seed dispersal distance, a comparison of diaspores falling through open air and through plant canopy was made in a wind tunnel using three wind speeds and diaspores with various traits. Compared with diaspores falling through open air, the dispersal distance of diaspores falling through plant canopy was decreased or increased, depending on wind …

New Inroads Into Our Understanding Of The Tauopathies, Alzheimer's Disease, And The Contribution Of Altered Protein Conformation To Human Neurological Disease, Walter J. Lukiw

School of Medicine Faculty Publications

No abstract provided.

The Epiphytic Diatom Community Of An Invasive Macroalga, Starry Stonewort (Charales: Nitellopsis Obtusa) And Its Native Relative, Chara Contraria (Charales) From Two Drowned River Mouth Lakes, Kelsey Inman-Carter

Student Summer Scholars Manuscripts

Epiphytic diatoms are essential primary producers in aquatic environments, but the relationship between them and their hosts is not well understood. The purpose of this project is to understand the specificity of a macroalgal host-epiphytic diatom relationship in Pentwater and Muskegon Lakes, and compare the epiphytic diatom communities of the invasive Nitellopsis obtusa to its close native relative, Chara contraria, using a metabarcoding approach. To these ends, host samples were collected monthly from July to September in 2020 (90 samples) and in June 2021 (55 samples). DNA was extracted from each sample and the plastid RUBISCO (rbcL) barcoding region of …

Lncrnafunc: A Knowledgebase Of Lncrna Function In Human Cancer, Pora Kim, Xiaobo Zhou

Faculty, Staff and Student Publications

The long non-coding RNAs associating with other molecules can coordinate several physiological processes and their dysfunction can impact diverse human diseases. To date, systematic and intensive annotations on diverse interaction regulations of lncRNAs in human cancer were not available. Here, we built lncRNAfunc, a knowledgebase of lncRNA function in human cancer at https://ccsm.uth.edu/lncRNAfunc, aiming to provide a resource and reference for providing therapeutically targetable lncRNAs and intensive interaction regulations. To do this, we collected 15 900 lncRNAs across 33 cancer types from TCGA. For individual lncRNAs, we performed multiple interaction analyses of different biomolecules including DNA, RNA, and protein levels. …

Fusiongdb 20: Fusion Gene Annotation Updates Aided By Deep Learning, Hyesoo Jung, Himanshu Kumar, Xiaobo Zhou

Faculty, Staff and Student Publications

A knowledgebase of the systematic functional annotation of fusion genes is critical for understanding genomic breakage context and developing therapeutic strategies. FusionGDB is a unique functional annotation database of human fusion genes and has been widely used for studies with diverse aims. In this study, we report fusion gene annotation updates aided by deep learning (FusionGDB 2.0) available at https://compbio.uth.edu/FusionGDB2/. FusionGDB 2.0 has substantial updates of contents such as up-to-date human fusion genes, fusion gene breakage tendency score with FusionAI deep learning model based on 20 kb DNA sequence around BP, investigation of overlapping between fusion breakpoints with 44 human …

Water Use Characteristics Of Weeds: A Global Review, Best Practices, And Future Directions, Mandeep Singh, Meetpal Singh Kukal, Suat Irmak, Amit J. Jhala

Department of Agronomy and Horticulture: Faculty Publications

Weeds usually penalize crop yields by competing for resources, such as water, light, nutrients, and space. Most of the studies on the crop-weed competition domain are limited to assessing crop-yield losses due to weed pressure and other crop-weed interactions, overlooking the significant uptake of soil-water by weeds that exacerbates global water constraints and threatens the productivity and profitability. The objective of this review was to synthesize globally available quantitative data on weed water use (WU) sourced from 23 peer-reviewed publications (filtered from 233 publications via a multi-step protocol of inclusion criteria) with experimental investigations across space (3 continents), time (1927–2018), …

Grassland Landscape Design: Working With Land-Managers, C. J. Pearson, R. K. Mann, I. G. Mann

IGC Proceedings (1977-2023)

We are entering an era of landscape design in order to simultaneously tackle largescale issues such as salinity and rising water tables, whole-farm profitability and the maintenance or enhancement of rural communities. In Australia, an important element of landscape design will be the reintroduction or broadening of the base of perennial grasses within farm systems. The goal of this project was to accelerate awareness and adoption of perennial grasses in a large but ecologically-specific area, namely the already-cleared steep uplands in the high rainfall recharge areas of the Murray-Darling Basin. We used a participatory model, in which land-managers made monthly …

Results With Methods For Measuring Herbage Mass In Situ, G. Nagy, I. Vinczeffy, K. Petõ

IGC Proceedings (1977-2023)

Two indirect methods for estimating herbage mass in situ were investigated in a research programme. Electric capacitance and spectral reflectance measurements were made and estimated values were compared with cut herbage mass results. Vegetation indexes (VI) measured by spectroradiometer showed a high correlation with fresh herbage mass, but there was no correlation observed between VI and dry matter results. Equations installed in electric capacitance meter were not feasible for Hungarian conditions. The change of electric capacitance in the sward (CMR) gave no correlation with cut DM yields. The investigated indirect methods are not suitable for research or production use yet.

Application Of Municipal Biosolids To Bahiagrass Pasture: Trace Metals In Harvested Forage, R. M. Muchovej, J. E. Rechcigl

IGC Proceedings (1977-2023)

Municipal biosolids (sewage sludge) are the by-products of wastewater treatment plants and their production, worldwide, has steadily increased over the past years. Florida is one of the fastest growing states in the USA. Biosolids are readily and increasingly available throughout the state. Pasture fertilization has been shown to increase biomass and quality of bahiagrass (Paspalum notatum Flugge) dramatically in Florida sandy soils. Nevertheless, with low cattle prices, ranchers are forced to reduce fertilizers inputs. Biosolids contain considerable amounts of nutrients, especially nitrogen (N), phosphorus (P), sulphur (S), calcium (Ca), and micronutrients, and are inexpensive when compared with commercial fertilizers. …

Rangelands Vegetation Mapping At Species Composition Level Using The Spicla Method: SDm Based PiXel ClaSsification And Fuzzy Accuracy. A New Approach Of Map Making, A. G. Toxopeus, C. A. J. M. De Bie, E. H. Kloosterman, J. K. Mbaluka, P. K. Mwangi, L. G. J. Boerboom

IGC Proceedings (1977-2023)

Vegetation maps have been made since centuries. The vegetation cover was represented as homogeneous mapping units (polygons), representing different vegetation types, where each type consists a combination of different plant species (floristic composition). More recent, with the use of satellite imagery, the polygons have been replaced by pixels with similar content as the polygon maps. In both approaches, field-observations were linked to the mapping units (polygons or pixels) often resulting in a complex of different vegetation types per mapping unit. In our new approach field data (sample points) on presence and abundance of individual grass species are spatially extrapolated based …

Adoption And Influence: Industry Evaluation Of The GrassgroTm Decision Support Tool, E. M. Salmon, A. D. Moore

IGC Proceedings (1977-2023)

The GrassGro Decision Support tool (DS tool) (Donnelly and Moore, 1999) was released for commercial use in Australia with a training package in late 1997. An assessment of its adoption was made by a survey of 53 registered users in March 1999. An evaluation of the software and training package was made at training workshops by 92 users between 1997 and December 1999. The response rates to the survey and the evaluation were 62% and 82% respectively. Seventy six percent of survey respondents had analysed at least one problem with GrassGro and 27% had applied GrassGro to five or more …

Digestibility Estimates Based On A Grass Growth Model Are Distributed Via Internet To Finnish Farmers, Marketta Rinne, J. Nousiainen, I. Mattila, H. Nikander, P. Huhtanen

IGC Proceedings (1977-2023)

Optimising the harvesting time of grass in primary growth is difficult under Finnish climatic conditions, because the digestibility of grass decreases on average by 0.5 percentage units daily. We constructed a model based on cumulative temperature and geographical location which estimates the digestibility of grass. This model is used to produce estimates utilising real time weather information. The estimates are presented as a map, which is revised daily. Farmers have free access to the maps via Internet.

Guide To The Dundee Fruit Growers Association Collection, Linfield University Archives

Linfield Archives Finding Aids

This collection contains banking records, stock share records, business records, tax reports, and advertisements from Dundee (Oregon) Fruit Growers Association. These items span the years of 1914-1944.

Reducing Tillage Affects Long-Term Yields But Not Grain Quality Of Maize, Soybeans, Oats, And Wheat Produced In Three Contrasting Farming Systems, Kirsten Ann Pearsons, Emmanuel Chiwo Omondi, Brad J. Heins, Gladis Zinati, Andrew Smith, Yichao Rui

Agricultural and Environmental Sciences Faculty Research

Reducing tillage has been widely promoted to reduce soil erosion, maintain soil health, and sustain long-term food production. The effects of reducing tillage on crop nutritional quality in organic and conventional systems, however, has not been widely explored. One possible driver of crop nutritional quality might be the changing soil nitrogen (N) availability associated with reduced tillage in various management systems. To test how reducing tillage affects crop nutritional quality under contrasting conventional and organic farming systems with varied N inputs, we measured nutritional quality (protein, fat, starch, ash, net energy, total digestible nutrients, and concentrations of Ca, K, Mg, …

Glycocalyx Mechanotransduction Mechanisms Are Involved In Renal Cancer Metastasis, Heriberto Moran, Limary M. Cancel, Peigen Huang, Sylvie Roberge, Tuoye Xu, John M. Tarbell, Lance L. Munn

Publications and Research

Mammalian cells, including cancer cells, are covered by a surface layer containing cell bound proteoglycans, glycoproteins, associated glycosaminoglycans and bound proteins that is commonly referred to as the glycocalyx. Solid tumors also have a dynamic fluid microenvironment with elevated interstitial flow. In the present work we further investigate the hypothesis that interstitial flow is sensed by the tumor glycocalyx leading to activation of cell motility and metastasis. Using a highly metastatic renal carcinoma cell line (SN12L1) and its low metastatic counterpart (SN12C) we demonstrate in vitro that the small molecule Suberoylanilide Hydroxamic Acid (SAHA) inhibits the heparan sulfate synthesis enzyme …

The Effect Of Batter Characteristics On Protein-Aided Control Of Fat Absorption In Deep-Fried Breaded Fish Nuggets, Lulu Cui, Jiwang Chen, Yuhuan Wang, Youling L. Xiong

Animal and Food Sciences Faculty Publications

Soy protein (SP), egg white protein (EP), and whey protein (WP) at 6% w/w were individually incorporated into the batter of a wheat starch (WS) and wheat gluten (WG) blend (11:1 w/w ratio). Moisture adsorption isotherms of WS and proteins and the viscosity, rheological behavior, and calorimetric properties of the batters were measured. Batter-breaded fish nuggets (BBFNs) were fried at 170 °C for 40 s followed by 190 °C for 30 s, and pick-up of BBFNs, thermogravimetric properties of crust, and fat absorption were determined. The moisture absorption capacity was the greatest for WS, followed by WG, SP, EP, and …

Distribution Of Serotypes And Antibiotic Resistance Of Invasive Pseudomonas Aeruginosa In A Multi-Country Collection, Shamima Nasrin, Nicolas Hegerle, Shaichi Sen, Joseph Nkeze, Sunil Sen, Jasnehta Permala-Booth, Myeongjin Choi, James Sinclair, Milagritos D. Tapia, Sadia Shakoor

Department of Pathology and Laboratory Medicine

Background: Pseudomonas aeruginosa is an opportunistic pathogen that causes a wide range of acute and chronic infections and is frequently associated with healthcare-associated infections. Because of its ability to rapidly acquire resistance to antibiotics, P. aeruginosa infections are difficult to treat. Alternative strategies, such as a vaccine, are needed to prevent infections. We collected a total of 413 P. aeruginosa isolates from the blood and cerebrospinal fluid of patients from 10 countries located on 4 continents during 2005-2017 and characterized these isolates to inform vaccine development efforts. We determined the diversity and distribution of O antigen and flagellin types and …

Rare Coding Variants In 35 Genes Associate With Circulating Lipid Levels-A Multi-Ancestry Analysis Of 170,000 Exomes, Minxian Wang, Joseph Park, Carlos A Aguilar-Salinas, Lucinda Antonacci-Fulton, Diego Ardissino, Donna K Arnett, Stella Aslibekyan, Gil Atzmon, Christie M Ballantyne, Francisco Barajas-Olmos, Nir Barzilai, Lewis C Becker, Lawrence F Bielak, Joshua C Bis, John Blangero, Eric Boerwinkle, Lori L Bonnycastle, Erwin Bottinger, Matthew J Bown, Jennifer A Brody, Jai G Broome, Noël P Burtt, Brian E Cade, Federico Centeno-Cruz, Edmund Chan, Yi-Cheng Chang, Yii-Der I Chen, Ching-Yu Cheng, Won Jung Choi, Rajiv Chowdhury, Cecilia Contreras-Cubas, Emilio J Córdova, Adolfo Correa, L Adrienne Cupples, Joanne E Curran, John Danesh, Paul S De Vries, Ralph A Defronzo, Harsha Doddapaneni, Ravindranath Duggirala, Susan K Dutcher, Patrick T Ellinor, Leslie S Emery, Jose C Florez, Myriam Fornage, Barry I Freedman, Valentin Fuster, Ma Eugenia Garay-Sevilla, Humberto García-Ortiz, Soren Germer, Richard A Gibbs, Christian Gieger, Benjamin Glaser, Clicerio Gonzalez, Maria Elena Gonzalez-Villalpando, Mariaelisa Graff, Sarah E Graham, Niels Grarup, Leif C Groop, Xiuqing Guo, Namrata Gupta, Sohee Han, Craig L Hanis, Torben Hansen, Jiang He, Nancy L Heard-Costa, Yi-Jen Hung, Mi Yeong Hwang, Marguerite R Irvin, Sergio Islas-Andrade, Gail P Jarvik, Hyun Min Kang, Sharon L R Kardia, Tanika Kelly, Eimear E Kenny, Alyna T Khan, Bong-Jo Kim, Ryan W Kim, Young Jin Kim, Heikki A Koistinen, Charles Kooperberg, Johanna Kuusisto, Soo Heon Kwak, Markku Laakso, Leslie A Lange, Jiwon Lee, Juyoung Lee, Seonwook Lee, Donna M Lehman, Rozenn N Lemaitre, Allan Linneberg, Jianjun Liu, Ruth J F Loos, Steven A Lubitz, Valeriya Lyssenko, Ronald C W Ma, Lisa Warsinger Martin, Angélica Martínez-Hernández, Rasika A Mathias, Stephen T Mcgarvey, Ruth Mcpherson, James B Meigs, Thomas Meitinger, Olle Melander, Elvia Mendoza-Caamal, Ginger A Metcalf, Xuenan Mi, Karen L Mohlke, May E Montasser, Jee-Young Moon, Hortensia Moreno-Macías, Alanna C Morrison, Donna M Muzny, Sarah C Nelson, Peter M Nilsson, Jeffrey R O'Connell, Marju Orho-Melander, Lorena Orozco, Colin N A Palmer, Nicholette D Palmer, Cheol Joo Park, Kyong Soo Park, Oluf Pedersen, Juan M Peralta, Patricia A Peyser, Wendy S Post, Michael Preuss, Bruce M Psaty, Qibin Qi, D C Rao, Susan Redline, Alexander P Reiner, Cristina Revilla-Monsalve, Stephen S Rich, Nilesh Samani, Heribert Schunkert, Claudia Schurmann, Daekwan Seo, Jeong-Sun Seo, Xueling Sim, Rob Sladek, Kerrin S Small, Wing Yee So, Adrienne M Stilp, E Shyong Tai, Claudia H T Tam, Kent D Taylor, Yik Ying Teo, Farook Thameem, Brian Tomlinson, Michael Y Tsai, Tiinamaija Tuomi, Jaakko Tuomilehto, Teresa Tusié-Luna, Miriam S Udler, Rob M Van Dam, Ramachandran S Vasan, Karine A Viaud Martinez, Fei Fei Wang, Xuzhi Wang, Hugh Watkins, Daniel E Weeks, James G Wilson, Daniel R Witte, Tien-Yin Wong, Lisa R Yanek, Amp-T2d-Genes, Myocardial Infarction Genetics Consortium, Nhlbi Trans-Omics For Precision Medicine (Topmed) Consortium, Nhlbi Topmed Lipids Working Group, Sekar Kathiresan, Daniel J Rader, Jerome I Rotter, Michael Boehnke, Mark I Mccarthy, Cristen J Willer, Pradeep Natarajan, Jason A Flannick, Amit V Khera, Gina M Peloso

Faculty, Staff and Student Publications

Large-scale gene sequencing studies for complex traits have the potential to identify causal genes with therapeutic implications. We performed gene-based association testing of blood lipid levels with rare (minor allele frequency < 1%) predicted damaging coding variation by using sequence data from >170,000 individuals from multiple ancestries: 97,493 European, 30,025 South Asian, 16,507 African, 16,440 Hispanic/Latino, 10,420 East Asian, and 1,182 Samoan. We identified 35 genes associated with circulating lipid levels; some of these genes have not been previously associated with lipid levels when using rare coding variation from population-based samples. We prioritize 32 genes in array-based genome-wide association study (GWAS) loci based on aggregations of rare coding variants; three (EVI5, …