Life Sciences Commons^™

Waste Streams From Next Generation Molten Salt Reactors: The Challenge Of Creating An Insoluble Ceramic For Chloride Salt Waste, Alevtina A. Maksimova, Jake W. Amoroso, Matthew Page, Gregory Morrison, Hans Conrad Zur Loye

Faculty Publications

Molten salt reactors (MSRs) design development is of interest to many research groups and companies. Waste management for MSRs is one of the most important issues that needs to be resolved due to its impact on environmental safety, primarily via the dissolution of radionuclides in water. Furthermore, the waste treatment strategy will have a significant influence on the operating cost of MSRs, which is why a reliable process for the immobilization, transportation, storage and disposal of MSR waste must be addressed. This work presents a new approach for the immobilization of chloride salts from molten salt reactors in stable oxyhalide …

Crystal Structure Of New Polar Rare Earth Borates Na2.62Ln2.12(Bo3)3 (Ln = Pr, Nd, Sm) Containing Isolated Bo3 Groups, Alevtina A. Maksimova, Mark D. Smith, Hans Conrad Zur Loye

Faculty Publications

Three new rare earth borates, Na2.62Ln2.12(BO3)3 (Ln = Pr, Nd, Sm), were synthesized via a high-temperature solution reaction using a BaCO3–H3BO3–NaF flux and structurally characterized by single-crystal X-ray diffraction analysis. The compounds crystallize in the orthorhombic space group Amm2 with lattice parameters a = 5.0985(10) Å, b = 11.180(2) Å, c = 7.1483(14) Å, and a unit cell volume of 407.48(14) ų (Z = 2) for Na2.62Pr2.12(BO3)3, a = 5.0983(10) Å, b = 11.181(2) Å, c = 7.1491(14) Å, and a unit cell volume of 407.51(14) ų (Z = 2) for Na2.62Nd2.12(BO3)3, and a = 5.08630(10) Å, b …

Single Crystal Growth Of The Orthoborate Nabalu(Bo3)2 And Optical Investigation Of Eu3+ And Tb3+ Doped Nabalu(Bo3)2, Alevtina A. Maksimova, Mark D. Smith, Lakshani W. Masachchi, Hans Conrad Zur Loye

Faculty Publications

Sodium barium lutetium borate NaBaLu(BO₃)₂ crystals were synthesized using a high-temperature solution method. The crystal structure of this layered orthoborate is described and corresponds to that of an extensive orthoborates family, NaBaR(BO₃)₂ (R = Sc, Y, Yb, Tb – Lu). NaBaLu(BO₃)₂ was doped by Eu³⁺ and Tb³⁺ to explore its performance as a host material and to investigate the luminescent properties of the Eu³⁺ and Tb³⁺ doped materials. The emission spectra of the NaBaLu(BO₃)₂:Ln (Ln = Eu, Tb) crystals are presented. The most …

Main-Chain Ion-Pair Polybenzimidazole Membranes Enabling Reduced-Temperature Ht-Pemfc Operation (Down To 120°C), Brian C. Benicewicz, Huina Lin

Faculty Publications

Proton exchange membrane (PEM) fuel cells are promising for clean and efficient energy conversion across diverse applications. High-temperature PEM fuel cells (HT-PEMFCs) using phosphoric acid (PA)-doped polybenzimidazole (PBI) can operate up to 200°C, but at lower temperatures, water-induced PA loss often leads to performance degradation and reduced durability. In this work, we present a new class of main-chain ion-pair PBI membranes by integrating the imidazolium-biphosphate ion-pair units directly into the PBI backbone. This design results in membranes with high acid content, stronger acid-polymer interactions and stabilized acid retention. In single-cell tests, the Im+-PBI15-3 wt.% exhibits peak power densities of 0.79 …

Recent Advances In The Juvenile-To-Adult Phase Transition, Yifei Liao, Mingli Xu

Faculty Publications

The transition from the juvenile to adult vegetative phase in Arabidopsis thaliana is a fundamental developmental process that integrates morphological and physiological maturation. Despite extensive study, how vegetative phase change is regulated and how this phase transition is coordinated with plant physiology remain incompletely understood. This review synthesizes recent advances in the molecular regulation and physiological functions of vegetative phase change. We summarize how developmental traits—such as leaf shape, trichome distribution, and margin serration—are controlled through distinct downstream targets of the age-dependent miR156–SPL pathway. We further highlight emerging insights into how epigenetic factors dynamically modify chromatin states of key regulatory …

The Phoenix Flora: Plant Survival, Succession, And Putative Adaptation In The Post-Atomic Landscapes Of Hiroshima And Nagasaki, Gian Marco Ludovici, Paola Amelia Tassi, Alba Iannotti, Colomba Russo, Fausto D'Agostino, Matilde Neble Segade, Timothy Mousseau, Andrea Malizia

Faculty Publications

The atomic bombings of Hiroshima and Nagasaki in 1945 created a unique environment of acute, high-dose ionizing radiation, contrasting sharply with the chronic low-dose rate exposure in the Chernobyl and Fukushima Exclusion Zones. This stands in stark contrast to the chronic, low-dose rate contamination that defines the Chernobyl and Fukushima Exclusion Zones. While the long-term ecological effects of the latter are well-documented, a systematic synthesis of the floral response to the atomic bombings is lacking. This review integrates historical data with modern radio-ecological principles to analyze plant survival and succession. We document the remarkable recovery of vegetation, from the resprouting …

The Phoenix Flora: Plant Survival, Succession, And Putative Adaptation In The Post-Atomic Landscapes Of Hiroshima And Nagasaki, Gian Marco Ludo, Paola Amelia Tassi, Alba Iannotti, Colomba Russo, Fausto D'Agostino, Matilde Neble Segade, Timothy Mousseau, Andrea Malizia

Faculty Publications

The atomic bombings of Hiroshima and Nagasaki in 1945 created a unique environment of acute, high-dose ionizing radiation, contrasting sharply with the chronic low-dose rate exposure in the Chernobyl and Fukushima Exclusion Zones. This stands in stark contrast to the chronic, low-dose rate contamination that defines the Chernobyl and Fukushima Exclusion Zones. While the long-term ecological effects of the latter are well-documented, a systematic synthesis of the floral response to the atomic bombings is lacking. This review integrates historical data with modern radio-ecological principles to analyze plant survival and succession. We document the remarkable recovery of vegetation, from the resprouting …

A Herpetological Survey Of The Catawba Nation, York County, South Carolina, Courtney Skeldon, Marvin Bouknight, Steven E. Fields

Journal of the South Carolina Academy of Science

No abstract provided.

The Ccu Disease Hunters: Putting Undergraduate Research To Work To Improve Community Health And Training The Next Generation Of Doctors, Paul E. Richardson

Journal of the South Carolina Academy of Science

No abstract provided.

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.

Reptiles Of The Northeastern Piedmont Of South Carolina, Steven E. Fields

Journal of the South Carolina Academy of Science

No abstract provided.

Attentional Mechanisms Of Language In Infants With Down Syndrome, Fragile X Syndrome And Siblings Of Children With Autism, Isabelle Robinson

Caravel Undergraduate Research Journal

Children with Down syndrome (DS), fragile X syndrome (FXS), or younger siblings of a child with autism spectrum disorder (ASIB) often exhibit atypical object exploration and social engagement, which can affect important learning opportunities. The purpose of this study was to examine group differences in social attention shifting and attentional disengagement between infants with DS, FXS, and ASIBs. This study utilized data from a longitudinal study collected from 12-month-old infants with DS (n = 13), FXS (n = 14), and ASIBs (n = 24). No group differences were seen for social attention shifting. However, infants with DS …

Examining Biobehavioral Indicators Of Adhd In Children With Fxs, Hannah Pressler, Kayla Smith, Ramsey Coyle, Elizabeth Will, Jane E. Roberts

Caravel Undergraduate Research Journal

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention and hyperactivity/impulsivity behaviors that are inconsistent with developmental age. Children with fragile X syndrome (FXS), a genetic neurodevelopmental disorder, are often diagnosed with comorbid ADHD (53–59% of males with FXS). Despite the prevalence of ADHD in FXS, little is known about the early manifestation of ADHD. The current project aims to explore group differences in play behaviors between children with FXS and typically developing (TD) children as well as the relationship between infant play behavior and heart activity to future ADHD attention outcomes. Participants included male children with FXS and …

Optimizing Expression Conditions For The Overexpression Of Iron Regulatory Protein Bol2 From C. Glabrata, Jade Ikahihifo-Bender, Dr. Caryn Outten, Mrs. Evan Talib

Caravel Undergraduate Research Journal

Due to its unique ability to serve as both an electron donor and acceptor, iron is utilized as a co-factor for many biological processes, including electron transfer, oxygen binding, and vitamin synthesis. Iron is also a key factor during fungal infections as the human host and invading pathogens battle over limited iron pools. The primary iron-responsive transcription factor Aft1 in the opportunistic pathogenic yeast Candida glabrata responds to iron deficiency by activating expression of iron acquisition genes. However, the mechanisms for sensing intracellular iron levels and regulating Aft1 activity in response to iron are unknown. The C. glabrata iron regulation …

The Universe Under A Microscope, Claire Chabot

Caravel Undergraduate Research Journal

No abstract provided.

Early Behavioral And Physiological Predictors Of Autism In 12-Month-Old Siblings Of Children With Autism, Nicolas Poupore, Kayla Smith, Abigail L. Hogan, Jane E. Roberts Ph.D.

Caravel Undergraduate Research Journal

Autism spectrum disorder (ASD) is a neurodevelopmental disorder defined by social-communicative deficits and repetitive behaviors. Complementing behavioral (i.e., The Autism Observation Scale for Infants (AOSI) scores) and physiological markers (i.e., respiratory sinus arrhythmia (RSA), heart rate (HR)) may improve early identification of ASD and provide insights into the neurobiological mechanisms contributing to early ASD symptoms. Younger siblings of a child with ASD (ASIBs) had significantly higher AOSI Total Scores and AOSI Marker Scores in comparison to Low Risk Controls (LRCs). RSA significantly decreased from a Baseline to AOSI for both groups, but only for the ASIB group was a negative …

Injuries In Youth Football: A Two Year Descriptive Study Of Local South Carolina Football Leagues, Marie Morrissette, Dr. Jim Mensch, Dr. Daheia Barr-Anderson

Caravel Undergraduate Research Journal

There has been an increase in the media attention surrounding retired National Football League players and the lasting effects from previous injuries.  With more than 20 million children under the age of 17 participating in competitive sports, the attention in the lasting effects of injuries in professional players has trickled down to the youth level.  Of the approximately 20 million children participating in competitive sports, the largest portion of the participants is playing youth football.  The University of South Carolina Athletic Training Department is partaking in a multisite research study conducted by the Datalys Center to track the injuries of …

Discovering The Southern Appalachian Grassy Balds, Nicholas Lenze

Caravel Undergraduate Research Journal

Grassy balds are unique Appalachian wonders, open meadows in the mountains where, ecologically, there should be trees. It has been hypothesized that some of the balds originated more than ten thousand years ago and were kept open by the grazing of large herbivores such as the mastodon and the wooly mammoth. Over the course of earth’s history, environmental and anthropogenic factors have shaped, modified and maintained the balds. Up to one hundred grassy balds were once recognized to exist in the southern Appalachians, but fewer exist today due to forest succession (Gersmehl, 1970). Collectively, the grassy balds share a common …

The Cranial Morphology Of Large Wild Versus Captive Felids, Bryttin Boyde, Hannah Selvey

Caravel Undergraduate Research Journal

Studies have shown that carnivores in captivity that are fed soft diets have more periodontal problems and that the morphology of their skeletons, skulls specifically, responds to environmental and behavior factors. Considering that captive diet affects teeth and gums, we have conducted research on Dr. Adam Hartstone-Rose’s hypothesis that variation will also be discernible through the examination of cranial morphology. We compared captive and wild lions Panthera leo and tigers Panthera tigris to see if differences were present, then analyzed data collected by a microscribe using a 3D morphometric analysis program. Next, Principal Component Analysis was completed to account for …

A Review Of Video Game Effects And Uses, David Corso

Caravel Undergraduate Research Journal

Video games are versatile in their form and function. Whether they’re training doctors or offsetting Alzheimer’s disease, video games can exercise both mental and physical features, train specific skills for a number of jobs, educate players about events and phenomenon in our world, research and understand natural human processes, and they can be designed for a number of other purposes. Multiple studies have demonstrated the effects of video games on physiological and cognitive levels—positive, negative, and everything in between. This paper identifies various physical and psychological effects that video games produce, and it suggests ways in which video games can …

Learning About Learning: Cognitive Gaming As A Technology Of The Self, David Corso

Caravel Undergraduate Research Journal

Humans perceive and interpret video games in various ways. When viewed as a cognitive process, video games facilitate intellectual growth and development. This piece analyzes selected works by French intellectual Michel Foucault and educational game design researcher Kurt Squire to explain how video game play elicits various cognitive and metacognitive processes. The video discusses how gameplay contributes to the development of cognitive skills, such as memory and attention. It explains how gameplay facilitates learning about learning as well as how video games provide transferable knowledge. An interpretation of Foucault’s “technology of the self” indicates how individuals might use gameplay to …

Sequence Determinants Of Rna G-Quadruplex Unfolding By Arg-Rich Regions, Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui-Ting Lee, Jun Zhang

Faculty Publications

RNA sequences with the potential to form G-quadruplexes (rGQs) are widespread but largely unfolded in cells by unknown mechanisms. rGQ folding status is a critical regulator of RNA splicing and translation. We show that rGQs can be unfolded by SR proteins, SR-related proteins, and other Arg-rich proteins, including SRSF1, SRSF3, SRSF9, U1-70K, and U2AF1. The length and composition of Arg-rich regions are key determinants of this activity: Arg residues are the primary drivers, while acidic residues attenuate the unfolding activity. To unfold ARPC2 rGQ, at least 13 Arg residues are required. Our findings identify Arg-rich proteins as previously unrecognized, helicase-independent …

Wrky Transcription Factors: Integral Regulators Of Defence Responses To Biotic Stress In Crops, Dongjiao Wang, Ruize Zhang, Wenhui Zou, Yuanyuan Zhang, Wanying Zhao, Tingting Sun, Qibin Wu, Zheng Qing Fu, Youxiong Que

Faculty Publications

Crops are continually challenged by biotic stresses, including fungal, bacterial and viral pathogens and insect pests, which cause substantial yield and quality losses worldwide. WRKY transcription factors constitute a plant-specific and functionally diverse family that is central to immune regulation. Recent advances in genomic resources and multi-omics approaches have accelerated the identification and functional characterisation of WRKYs in crops. This review summarises the structural features and classification of WRKY genes and their genome-wide distribution across crop species. It also synthesises WRKY-centred regulatory modules that mediate resistance to major classes of biotic stress. In antifungal defence, WRKYs reinforce pattern- and effector-triggered …

From Disease To Pregnancy: Rethinking Cardiac Remodeling Through Fibroblast, Immune Cell, And Hormonal Interactions, Emily B. Ruggiero, Wayne Carver, Daping Fan, Edoe C. Goldsmith

Cell Biology and Anatomy Faculty Publications

Cardiac fibrosis is a central determinant of heart failure progression and arises from pathological remodeling characterized by fibroblast activation, myofibroblast differentiation, and excessive extracellular matrix deposition. In contrast, physiological remodeling permits adaptive cardiac growth without net fibrosis. Pregnancy represents an underexplored physiological model of reversible cardiac remodeling. In response to hemodynamic load, the maternal heart undergoes hypertrophic growth that resolves postpartum, constituting a natural paradigm of fibrosis-resistant cardiac adaptation. Pregnancy and lactation are accompanied by profound endocrine and immune reprogramming of maternal tissues. We propose that this hormonal milieu orchestrates coordinated crosstalk among endothelial cells, fibroblasts, and immune cell populations …

Roles Of Mads-Box Transcription Factors In Plant Responses To Abiotic And Biotic Stresses, Na Liu, Zihao Liu, Guangxiang Tian, Shijia Zhao, Hao Chu, Yiheng Hu, Yingfan Zhao, Yanyan Zhang, Kun Cheng, Daowen Wang, Wenming Zheng, Zhengqing Fu, Xu Wang

Faculty Publications

Plants deploy sophisticated adaptive mechanisms to mitigate the detrimental effects of abiotic stresses (drought, salinity, temperature extremes, and heavy metals) and biotic stresses (pathogens and senescence) on growth and productivity. Central to these responses are transcription factors (TFs) that orchestrate stress-responsive gene networks. Among TF families, MADS-box proteins, characterized by their evolutionarily conserved DNA-binding domain, function as pivotal regulators of developmental plasticity and stress adaptation. While recent advances have clarified their roles in abiotic stress tolerance, a systematic integration of their functions in biotic stress responses has yet to be achieved. This review synthesizes current knowledge on how MADS-box TFs …

Exploring Decision-Making In Caenorhabditis Elegans: Navigating Dichotomous Envrionmental Cues, Hunarmeet K. Gill

Caroliniana Undergraduate Research Journal

All living organisms thrive off the survival choices they make and the factors they prioritize, but the mechanisms guiding these choices remain unclear. This study investigates decision-making in Caenorhabditis elegans, aiming to understand how they navigate dichotomous environments that contain both attractive and aversive cues. Despite possessing a simple nervous system, C. elegans express behaviors indicating a level of advanced sensory-processing abilities, making them ideal models for studying decision-making processes. The experiment consisted of five separate petri-dish tests, each with three sections: side A and side B (containing natural or UV light and/or E.coli or ethanol), and a neutral …

Comparing The Effect Of Varying Concentrations Of Polytetrafluoroethylene On The Length And Fresh Weight Of Salvinia Minima, Talha Islam

Caroliniana Undergraduate Research Journal

The increasing usage of fluoropolymer pollution in aquatic environments has increased concerns about the ecological consequences of materials such as polytetrafluoroethylene (PTFE), commonly known as Teflon. In the past decade, the usage of Teflon in American homes across the United States has risen by 37.7%, resulting in large amounts of aquatic pollution due to improper disposal of these harmful substances (Török et al., 2020). Although PTFE is chemically inert, its accumulation in freshwater systems can introduce matter that physically interacts with aquatic organisms. This study examined how varying concentrations of PTFE suspensions affect the growth of Salvinia minima, a …

Emergence, Differentiation, And Modeling Of Hematopoietic Stem Cells In Developing Embryos, Lucy Shive

Caroliniana Undergraduate Research Journal

In the field of developmental biology, the understanding of embryogenesis is driven by ever-advancing techniques of studying embryos’ structures and behaviors. Yolk sacs are critical to an embryo’s survival and its function in producing a mature organism from a simple zygote. A hallmark of embryonic yolk sacs is their production of primitive hematopoietic stem cells (HSCs). Recent research has explored the mechanisms by which these HSCs develop and migrate, as well as the mechanisms by which they differentiate into various cell types. This more thorough understanding of HSCs is the basis for the development of embryo models, peri-gastruloids, from stem …

Psychosocial Mediators Of A Physical Activity And Dietary Intervention In Pregnant Women With Overweight Or Obesity, Meghan Baruth, Sarah Wilcox, Jihong Liu, Rebecca Schlaff

Faculty Publications

Background

Mediation analyses provide insight into both ‘pieces’ of the mediation chain; they allow us to look into the ‘black box’ that is behavior change. They allow researchers to better understand the ‘how’ of an intervention’s effects and/or the ‘why’ behind why an intervention worked or did not work. The lack of publications in pregnant populations highlights the need for additional studies to be conducted and published. The purpose of this study is to examine the psychosocial mediators of physical activity and dietary outcomes in a sample of pregnant women with overweight or obesity participating in the Health in Pregnancy …

New Species Of Kronosvirus Bacteriophages That Infect Caulobacter Strain Cbr1, Tannaz Mohammadi, Austin Millwood, Maherah Shaik, Bert Ely

Faculty Publications

Caulobacter segnis strain CBR1 enhances the germination rate and total biomass of Arabidopsis plants. Since bacteriophages are usually present in the rhizosphere, we isolated three additional bacteriophages, designated TMCBR2, TMCBR3, and W2, that can replicate using CBR1 as the host strain. The genome sizes and morphologies of the new phages were similar to those of the previously isolated Kronos phage, and when we compared the nucleotide sequence of these new phage genomes, we found only minor differences among the four phage genomes. Pairwise sequence comparisons indicated that the phage genomes should be grouped into three separate species within Kronosvirus genus. …