Life Sciences Commons^™

An Itpa Enzyme With Improved Substrate Selectivity, Nicholas E. Burgis, Kandise Vanwormer, Devin Robbins, Jonathan Smith

Chemistry and Biochemistry Faculty Publications

Recent clinical data have identified infant patients with lethal ITPA deficiencies. ITPA is known to modulate ITP concentrations in cells and has a critical function in neural development which is not understood. Polymorphism of the ITPA gene affects outcomes for both ribavirin and thiopurine based therapies and nearly one third of the human population is thought to harbor ITPA polymorphism. In a previous site-directed mutagenesis alanine screen of the ITPA substrate selectivity pocket, we identified the ITPA mutant, E22A, as a gain-of function mutant with enhanced ITP hydrolysis activity. Here we report a rational enzyme engineering experiment to investigate the …

Smokejumper Obituary: Kennedy, John Brent (Mccall 1987), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Smokejumper Obituary: Clements, Frank Robert (North Cascades 1988), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Smokejumper Obituary: Hall, David E. (Mccall 1980), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Smokejumper Obituary: Roos, Alford "Omar" (Redding 1983), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Smokejumper Obituary: Jessup, Gerald M. (North Cascades 1959), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Smokejumper Obituary: Komberec, Charles Richard "Dick" (Pilot 0000), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Smokejumper Obituary: May, Paul James (Missoula 1970), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Smokejumper Obituary: Cordova, Horace M. (Idaho City 1961), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Smokejumper Obituary: Hearn, Bernard Carter (Grangeville 1952), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Smokejumper Obituary: Mcdonald, Joseph Franklin "Joe" (West Yellowstone 1951), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Smokejumper Obituary: Simons, Charles Richard (Missoula 1952), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Smokejumper Obituary: Graves, Thomas Harry "Tom" (North Cascades 1949), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Smokejumper Obituary: Sando, Rodney Wayne (Missoula 1965), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Smokejumper Obituary: Silva, Michael Martin "Mike" (Redding 1972), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Smokejumper Obituary: Poppie, Wilford D. "Bill" (Missoula 1958 0000), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Smokejumper Obituary: Gunby, James F. "Jim" (Missoula 1952), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Smokejumper Obituary: Krane, Peer Pauli (North Cascades 1967), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Smokejumper Obituary: Carpino, Paul Samuel (Missoula 1952), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Smokejumper Obituary: Fairchild, Brett M. (Redmond 2005), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Smokejumper Obituary: Barber, Michael Stephen (Missoula 1968), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Smokejumper Obituary: Rolfs, Donald Arden "Don" (North Cascades 1959), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Smokejumper Obituary: Hatch, Charles R. "Chuck" (Grangeville 1963), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Meeting Minutes, October 16th, 2023, National Smokejumper Association Board Of Directors

National Smokejumper Association Meeting Minutes

1. Call to Order, Instructions, and Approval of the Agenda; 2. Approval of the Minutes; 4. Financials and Treasurer's Report; 5. Missoula Smokejumper Program; 5. Investment Committee; 6. TRAMPS; 7. Mann Gulch; 8. Grant Writer Report; 9. Scholarship Committee Report; 10. Historical Preservation Report; 11. Good Samaritan Fund Report; 12. Presentation to the Osher Life-long Learning Center (HO9); Northern California Use of Smokejumpers; and the Value of Associate Members; 13. Discussion of “Call to Action” by Michael Rains, for Possible NSA Support (H0a-n); 14. Motion Seeking Support of HR 934 Suppression of Wildfires. HO 11a, 11d-n); 15. Legislative Work on …

Smokejumper Obituary: Deeds, Jack Lee (Missoula 1965), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Smokejumper Obituary: Lowden, Robert G. (Cave Junction 1967), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Smokejumper Obituary: Stevenson, Vernon M. (Redding 1962), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Lichens Of Iller Creek: A Checklist For The Iller Creek Unit, A Division Of Dishman Hills Conservation Area, Spokane Valley, Wa, Devin M. Mumey, Giovanna Bishop, Jessica L. Allen

2023 Symposium

The field of biodiversity documentation encompasses a broad range of research including new species discovery and description, compilation of species present in a given area, and investigation of interspecies interaction. In an era of increasingly devastating and rapid environmental change, documenting biodiversity has become increasingly important. Anthropogenic effects on urban-adjacent natural areas are especially significant, as they can cause numerous, often drastic, responses in ecosystems. Our objective here was to document the lichen biodiversity in a large urban-adjacent protected area: the Iller Creek Unit of the Dishman Hills Conservation Area in Spokane Valley, Washington. This unit encompasses a diversity of …

Developing Cryopreservation Methods Of Wheat Roots, Ramanpreet Singh, Nguyen Khoi Nguyen, Taylor S. Matteucci

2023 Symposium

In the midst of record breaking rates of plant species extinction due to climate change and fungal diseases, a universal cryopreservation method would provide a means for preservation of these many different species. The concept of plant root cryopreservation first emerged in the late 1960’s, and with it came new avenues of preserving tissue for the purposes of agriculture and research. Frozen tissues can be transported and stored more reliably than other more conventional means. When thawed, they have the potential to be cultured and grown. Several different methods of cryopreservation exist. This experiment used the Fast (3°C/minute) and Slow …

Canine Testes Thin Sections Culture​, Nguyen Khoi Nguyen, Ramanpreet Singh

2023 Symposium

Canine testes thin section culture

Testes tissue culture systems would provide a tool to elucidate spermatogenesis mechanisms, with the aim of genetic preservation of mammals, especially endangered species. Our experiment aims to develop a culture system capable of producing viable mammalian sperm cells in vitro.

Dogs were chosen as the model organism because testes are readily available. Canine testes were obtained from a local veterinary clinic. Thin sections were generated using a commercial electric slicer. They then were cleaned using Dulbecco’s Phosphate-Buffered Saline (DPBS) supplemented with antibiotics then cultured in a modified Tissue Culture Medium 199 (TCM-199). Sections were …