Life Sciences Commons^™

Fractional Ablative Co2 Laser Versus Screw Threads In Post-Traumatic Atrophic Linear Scars, Eman Emad Elfeel, Marwa Zohdy Ali, Shereen Ezzalregal Alashry, Sherihan Hassan Allam

Mansoura Medical Journal

Background Scar is the result of the natural healing and reparative process, which are frequently accompanied by a few aesthetic, functional, and social impairments and may negatively affect quality of life. Fractional CO2 laser improves both the pigmentary and textural changes by removing thin layers of skin with minimal thermal damage. Thread lifting technology is a non-surgical facial rejuvenation technology that can minimize postoperative recovery period and scar from the incision Aim To compare the efficacy of fractional ablative CO2 laser therapy versus screw threads in post-traumatic atrophic linear scars. Methods This prospective randomized clinical study included 2 groups; group …

Methods Of Harvest And Compositional Characterization Of Hemp Fibers From Medical Cannabis Biomass Using Detergent Fiber Analysis, Abigail Lazier, Srishti Banerji, Jennifer Macadam, Bruce Bugbee

Publications

Medical cannabis production generates large quantities of stem biomass that is typically discarded despite its potential as a source of natural hemp fibers. This study developed and evaluated two methods for recovering fibers from greenhouse-grown medical cannabis using water retting and compared their composition with commercially produced industrial hemp fibers. Fiber quality was assessed using detergent fiber analyses to quantify cellulose, hemicellulose, and lignin fractions. Both harvest methods produced usable fibers, although one approach (method A) yielded cleaner fibers after shorter retting durations, while the second approach (method B) offered greater potential for large-scale processing. Increasing retting duration improved fiber …

History And Design Overview Of The Utah State University 16-Chamber Photobiology System, Abby Laughlin, Alec Hay, Bruce Bugbee

Controlled Environments

The USU Crop Physiology Laboratory has developed a 16-chamber system for photobiology research. At the time of the design in 2004, the CPL was collaborating with the Russian space agency on plant research and the chambers were constructed to match the dimensions of the Russian LADA plant growth system being flown on the International Space Station.

The Utah Reusable Root Module: Evapotranspiration Dynamics And Moisture Sensor Performance In Five-Month Reused Peat-Based Media, Claudia Garrido-Ruiz, Bruce Bugbee, Juan D. González-Teruel, Scott B. Jones

Controlled Environments

Efficient water management is essential for closed-loop food production in space applications. The Utah Reusable Root Module (URRM) is designed to support repeated cropping in the same peat-based growth media. Here, we report moisture sensor performance, nighttime-to-daytime evapotranspiration (ET) rate, yield, and water-use efficiency (WUE) in the Engineering Development Unit (EDU) using Outredgeous lettuce. Five previous crops had been planted in the same media, and this study reports growth and ET from the final crop cycle. Volumetric water content (θ_ᵥ) was monitored using two electromagnetic moisture sensors (CS650 and TEROS ONE) across five root modules (RMs) with multiple …

Assessment Of Soybean Response To Irrigation Variability In Eastern Nebraska Using The Aquacrop Model, Anmol Singh, Saleh Taghvaeian, Yufeng Ge, Derek M. Heeren, Frank Bai

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Soybean [Glycine max (L.) Merr.] is a major irrigated crop in eastern Nebraska, where recent expansions in irrigated agriculture and projected trends in irrigation demand necessitate thorough investigations of approaches that can optimize its irrigation management. In this study, the AquaCrop model was calibrated and validated using 19 variable irrigation treatments from a five-year field experiment. The model accurately simulated canopy cover, soil water content, and grain yield, with validation normalized root mean square error (nRMSE) of 12%, 7%, and 7%, respectively. The model was subsequently applied to estimate soybean yield and water requirement during a 15-year period (2010–2024) …

Dataset: The Impact Of External Resource Use On The Validity Of Score Interpretation For A Biology Concept Assessment Administered Out-Of-Class, Tiffany J. Burgess, Crystal Uminski, Gia Alicea, Brian A. Couch

School of Biological Sciences: Faculty Publications

Instructors use concept assessments to gauge student knowledge and guide course improvement. Many instructors experience time and logistical constraints around administering these assessments in class. For this reason, administering concept assessments outside of class can help increase feasibility. While previous studies have cautioned that the use of external resources (e.g., internet, course notes, peers) in the out-of-class setting may inflate assessment scores, the extent to which undergraduate students access various resources when completing concept assessments is unknown. The current study uses two survey question formats to better understand whether students engage with external resources when taking a biology concept assessment …

Adnexal Magnetic Resonance (Adnex –Mr) Scoring System; A New Standardized Method For Characterization Of Adnexal Masses Inside Mansoura University Hospitals, Nora Diaa Ali Okab, Basma Elged, Sherif Abdel Fatah Moustafa, Sieza Samir, Yasser.M. Mesbah

Mansoura Medical Journal

Background Gynecologic masses are the most common subject of gynecologic imaging. The usefulness of MRI is high in the characterization of adnexal masses. The ADNEX MR classification framework was launched to stratify sonographically identified adnexal masses in to five groups based on their probability of malignancy: grade 1 (no lesion), grade 2 (benign), grade 3 (probably benign), grade 4 (indeterminate), and grade 5 (probably malignant). Aim to determine the accuracy of the ADNEX MR scoring system in classification of adnexal masses at Mansoura University Hospitals (MUH). Methods A total of 48 female patients with 52 adnexal masses on ultrasound were …

Prevalence And Spectrum Of Genitourinary Anomalies In Children With Anorectal Malformations, Adnan El-Ghazaly, Tamer A. Wafa, Ahmed M. Negm, Adham W. El-Saied

Mansoura Medical Journal

Background: Anorectal malformations (ARMs) encompass a broad range of congenital defects and are frequently associated with genitourinary (GU) anomalies, which may contribute to long-term morbidity if undetected. This study aimed to determine the prevalence and spectrum of GU anomalies in children with ARMs, describe the urological and genital findings, and assess associations with sex and ARM type.

Patients and Methods: A prospective survey enrolled children diagnosed with ARMs at a tertiary pediatric surgery center. All patients underwent standardized clinical assessment, including focused genital examination and structured imaging. Abdominal ultrasonography (US) served as baseline screening for urinary tract anomalies. Voiding cystourethrogram …

Whole Tumor Apparent Diffusion Coefficient Histogram In Assessment Of Treatment Response In Locally Advanced Cervical Cancer, Wahdan. N, Wahba. H, Samir. S, Dina. G. Abdelzaher

Mansoura Medical Journal

Purpose:

We aimed to determine the prognostic value of whole-tumor ADC histogram analysis in predicting therapeutic outcomes for patients undergoing concurrent chemoradiotherapy (CCRT) for locally advanced cervical cancer (LACC).

Methods:

This prospective, single-institution study enrolled 40 women (mean age 53.8 ± 11.4 years) with pathologically confirmed LACC (FIGO stages IIB–IVA). Pelvic MRI including diffusion-weighted imaging (DWI) was performed at baseline and after CCRT. Whole-tumor regions of interest (ROIs) were manually delineated on ADC maps to extract histogram parameters (mean, minimum, maximum ADC, skewness, and kurtosis). Using RECIST 1.1 criteria, patients were classified as responders (complete or partial response) or …

Survivin And C-Reactive Protein Serum Levels In Acne Vulgaris Patients In Relation To Its Severity, Asmaa Ayman Gouda, Sara Hamdy Fouad, Hyam Sameh Nada, Hanan Ahmed Salem

Mansoura Medical Journal

Background: Acne vulgaris (AV) is a chronic inflammatory disease of the pilosebaceous unit with variable clinical severity. Increasing evidence suggests that acne may represent a localized inflammatory condition with potential systemic inflammatory involvement. Survivin, an inhibitor of apoptosis protein has been implicated in abnormal keratinocyte and sebocyte survival, while C-reactive protein (CRP) is a biomarker of systemic inflammation.

Aim of the study: To evaluate serum survivin and CRP levels in cases with AV compared to healthy controls and to assess their relationship with disease severity.

Subjects and methods: This case-control study included 45 patients with clinically diagnosed AV and 45 …

Clinical Outcomes Of Bloodstop Ix Application In Crico-Tracheal Resection And Anastomosis For Laryngotracheal Stenosis, Mohamed Yasser Elnaggar, Hisham Atef Ebada, Hossam Elsisi, Ali Tawfik

Mansoura Medical Journal

Objectives: To assess the surgical outcomes among laryngotracheal stenosis patients who underwent tracheal/crico-tracheal resection anastomosis for with application of BloodSTOP iX on the anastomotic line as well as the operative field.

Methods: Fourteen patients participated in this prospective study. The stenotic airway segment was resected circumferentially using primary end-to-end anastomosis. The authors of this article used the same standardized surgical techniques described in the literature and used by them previously. All patients had suprahyoid release, and trachea-hyoid de-tensioning stitches were inserted to reduce the anastomotic tension. To promote healing, BloodSTOP iX was administered across the anastomosis line and surgical outcomes …

Fetal Foot Length As A Predictor Of Gestational Age, Ruman Bashir Abdi Kadie, Hossam El-Dyn El-Sayed Gouda, Mohamad Ahmad El-Sayed Mohamad Emam, Alhussein Ahmed Mohamed

Mansoura Medical Journal

Background: Accurate estimation of gestational age (GA) is essential for obstetric care. Conventional ultrasound (US) biometric parameters may be limited in certain clinical situations. Fetal foot length (FFL) has been proposed as an alternative measurement, but its role requires further evaluation.

Aim of study: To examine the association between fetal foot length and ultrasound-based gestational age, and to explore its relationship with other fetal biometric parameters in uncomplicated singleton pregnancies.

Methods: This cross-sectional study included 200 pregnant women who underwent two-dimensional transabdominal ultrasound. Standard fetal biometric parameters—including biparietal diameter (BPD), head circumference (HC), abdominal circumference (AC), and femur length …

Quality-Of-Life Outcomes Of Tympanoplasty/Mastoidectomy Operations, Peter Shokr Meglaa, Ahmed Hemdan Eldeeb, Hisham Atef Abada, Yousef Kamel Shabana

Mansoura Medical Journal

Background: Chronic suppurative otitis media (CSOM) impairs quality of life (QoL) via otorrhea, hearing loss, and psychosocial effects, with surgery (tympanoplasty/mastoidectomy) as mainstay treatment despite limited patient-centered outcome data. This study aimed to evaluate QoL changes post-tympanoplasty/mastoidectomy in CSOM using validated tools.

Methods: This prospective study included 50 adults with CSOM at Mansoura University Hospitals. Pre/postoperative assessments included Chronic Otitis Media Outcome Test-15 (COMOT-15), Short Form-36 Health Survey (SF-36), Hearing Handicap Inventory for the Elderly-Screening (HHIE-S), Tinnitus Evaluation Questionnaire (TEQ), Situational Vertigo Questionnaire (SVQ), pure tone audiometry (PTA), and air-bone gap (ABG).

Results: PTA improved from 48.5±10.2 to 28.3±8.4 dB …

Frame: Fast Reference-Based Ancestry Makeup Estimation Tool, Pramesh Shakya, Ardalan Naseri, Degui Zhi, Shaojie Zhang

Faculty, Staff and Student Publications

Motivation: The availability of large-scale genetic data presents a unique opportunity to study the genetic ancestries of individuals, which requires an efficient and scalable method. The existing global ancestry methods are accurate, but they cannot scale to large genetic datasets. Identity-by-descent (IBD) segments are DNA segments shared by individuals such that they are inherited from a common recent ancestor without recombination. These IBD segments, which reflect co-ancestry, provide an efficient alternative for inferring genetic ancestry.

Results: We introduced a reference-based global ancestry inference method called FRAME (Fast Reference-based Ancestry Makeup Estimation). FRAME utilizes partial local ancestry information estimated through IBD …

The Ecological Consequences Of Horizontal Transmission Of Symbionts, Bibek Singh Parajuli

Biology Dissertations

Most multicellular organisms depend on their microbial symbionts for various functions, such as digestion, nutrient supplementation, pesticide degradation, and defense. While many insects acquire their symbionts vertically from their parents, thousands of species of true bugs (Hemiptera) across different families acquire their microbial symbiont, Caballeronia, from the environment each generation. Acquiring symbionts from the environment (horizontal transmission) has various ecological consequences for the host. In this study, I used the bug-Caballeronia model 1) to understand whether the free-living symbionts benefit from association with multicellular hosts, 2) to evaluate whether host specialization on symbiont strains varies across taxonomic levels, …

Effects Of Fermented Soybean Products On The Human Gut Microbiome, Microbial Metabolism, And Host Physiology, Shannon Moncier

Biology Dissertations

Fermented soybean products (FSPs) contain soybean-derived substrates, fermentation-associated microorganisms, and bioactive compounds that may interact with the human gut microbiome and host physiology. However, despite the growing interest in FSPs, longitudinal human studies specifically evaluating traditional Korean-FSPs (K-FSPs), particularly among United States-based populations, remain limited. The objective of this work was to evaluate the effects of three K-FSPs, including Cheonggukjang, Gochujang, and Doenjang, on host physiological responses, gut microbial community structure, predicted microbial functional potential, and fecal butyrate responses in healthy adults. Three independent dietary intervention cohorts were conducted using FSP formulations produced either by traditional artisan methods (Product A) …

Identifying Relevant Covariates In Rna-Seq Analysis By Pseudo-Variable Augmentation, Yet Nguyen, Dan Nettleton

Mathematics & Statistics Faculty Publications

RNA-sequencing (RNA-seq) technology allows for the identification of differentially expressed genes, which are genes whose mean transcript abundance levels vary across conditions. In practice, RNA-seq datasets often include covariates that are of primary interest in addition to a set of covariates that are subject to selection. Some of these covariates may be relevant to gene expression levels, while others may be irrelevant. Ignoring relevant covariates or attempting to adjust for the effect of irrelevant covariates can compromise the identification of differentially expressed genes. To address this issue, we propose a variable selection method that uses pseudo-variables to control the expected …

Investigation Of Genx Exposure To Pathways Associated With Colorectal Cancer Risk, Emily J. Ferguson

Theses and Dissertations--Toxicology and Cancer Biology

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants widely detected in drinking water and food sources, resulting in chronic human exposure. Among these compounds, hexafluoropropylene oxide dimer acid (HFPO-DA), commonly known as GenX, has been introduced as a short-chain replacement for legacy PFAS such as perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA). Although GenX is believed to be a safer alternative, emerging research suggests it can still affect human health.

Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer-related death in the United States, highlighting the need to better understand environmental …

Uncovering The Mechanism Of Reep2-Mediated Emt-Driven Membrane Trafficking In Lung Adenocarcinoma, Kevin Fulp

Theses and Dissertations--Toxicology and Cancer Biology

Membrane trafficking is frequently disrupted during cancer progression, and the underlying mechanisms remain largely unknown. Currently, no effective drugs target dysregulated membrane trafficking for cancer treatment. Recent evidence has demonstrated that epithelial-to-mesenchymal transition (EMT) in lung adenocarcinoma (LUAD) employs a membrane trafficking program to coordinate cancer cell invasion and immunosuppression. To further dissect the pro-tumorigenic membrane trafficking program, we initiated an in vivo CRISPRi screen to assess more than 2,000 membrane trafficking-related genes in a syngeneic mouse LUAD model. We identified REEP2, an endoplasmic reticulum (ER) shaping protein, as a novel regulator of EMT-driven membrane trafficking. High REEP2 expression is …

Reep2-Driven Pro-Metastatic Secretion Promotes Lung Cancer Progression, Oluwafunminiyi E. Obaleye

Theses and Dissertations--Toxicology and Cancer Biology

Membrane trafficking plays a critical role in cellular function and is frequently dysregulated in cancer to promote metastasis. In lung adenocarcinoma (LUAD), the epithelial-to-mesenchymal transition (EMT) activating transcription factor, ZEB1, drives a pro-metastatic membrane trafficking program; however, the underlying molecular mechanisms remain poorly understood. Using a CRISPR interference (CRISPRi) in vivo screen of 2,099 membrane trafficking regulators in a syngeneic mouse model of EMT-driven LUAD, we identified REEP2 — an endoplasmic reticulum (ER) shaping protein — as a critical regulator of tumor progression. REEP2 mRNA expression correlates with poor prognosis, EMT signatures, and an immunosuppressive tumor microenvironment in LUAD patients. …

From Sediment To Mangrove: Tissue-Specific Metal Accumulation In Red Mangroves Of Southeastern Florida, Sophie Welch

Honors Theses

Coastal wetlands near industrialized waterways face increasingly heavy‐metal contamination, posing risks to benthic communities and food webs. Mangroves can influence metal cycling through sediment trapping, root‐zone sequestration, and internal physiological regulation, yet their effectiveness in urbanized systems remains debated. This study quantified concentrations of 17 heavy metals in sediments and mangrove tissues from four sites near Port Everglades, Florida, examined tissue‐specific partitioning, spatial and temporal contamination patterns, and examined the mangroves’ role in mediating metal loads. Ecological risk metrics identified STB as a contaminant hotspot with exceedances of TEL values across multiple elements (Ni, Pb, and Zn) as well as …

Assessing The Impact Of Local–State Revenue Shares And Property Tax Structure On Effective Farmland Tax Rates: Panel Evidence From Seven Midwestern States, 2009–2022, Imtiaz Amin Chy

Electronic Theses and Dissertations

Property taxes are the primary revenue instrument of local governments in the United States, yet the burdens they impose are distributed unevenly. Farmland, because it cannot be relocated, often absorbs a disproportionate share. This paper examines two related questions: what fiscal factors determine how heavily agricultural land is taxed, and do those tax rates capitalize into farmland asset values? Using an annual panel of Iowa, Illinois, Indiana, Kansas, Minnesota, Nebraska, and Wisconsin from 2009 to 2022, we first document how each state allocates property tax revenue across four major spending categories (education, public welfare, health, and utilities) finding that all …

Accelerating The Discovery Of The Genetic And Molecular Bases Of Neurodevelopmental Disorders In Vivo Using Breasi-Crispr, Claire Mae Kittock

Dissertations and Theses

Many neurodevelopmental disorders occur due to perturbations in prenatal brain development. More genetic variants associated with neurodevelopmental disorders are continuously being identified. However, there is a lack of understanding of the pathogenic mechanisms. Here, we describe a novel application of the technique Breasi-CRISPR in modeling specific patient variants in the embryonic mouse brain. Breasi-CRISPR is a highly efficient system combining in utero electroporation with CRISPR-CAS9 genome editing. We hypothesized that Breasi-CRISPR would be sufficient at inserting patient analogous variants into endogenous loci to be used as a new paradigm for modeling neurodevelopmental disorders. We aimed to test if Breasi-CRISPR could …

The Effect Of Different Nutrient Concentrations For Hydroponically Grown Pothos, Keaton Roether

A with Honors Projects

An experiment where Pothos plants are grown in three different solutions of water, NPK diluted into water, tap water, and distilled water. Data is recorded for multiple weeks and is then compiled into a comprehensible lab report of a minimum of 1000 words with graphs and data.

Crispr-Cas9: Transforming Biomedical Technology Through Gene Editing, Zaina Issa

A with Honors Projects

The research paper describe the gene editing technique CRISPR-Cas9 and the implications of its use in different fields, including medicine and agriculture.

The Neuroprotective And Synergistic Effects Of Carbamoylated Erythropoietin And Insulin-Like Growth Factor-1 In Alzheimer's Disease, Morgan Jean Rothschadl

Dissertations and Theses

Alzheimer’s disease (AD) is a prominent neurodegenerative disease characterized by a decline in cognitive functioning. While current FDA-approved therapeutics exist, they fall short in creating significant and long-lasting improvements to cognition. A newer approach using neurotrophic factors has shown promising effects on improving cognition in clinical trials. Neurotrophic factors are secreted proteins that have multimodal effects in the brain, including supporting cell survival and functioning. Two neurotrophic factors of interest are carbamoylated erythropoietin (CEPO) and insulin-like growth factor-1 (IGF-1), and the goal of this study was to understand the synergistic and neuroprotective effects of CEPO and IGF-1 in AD. We …

Avian Use Of Early Successional Riparian Forest Along The Missouri River: What Do We Lose By Managing For Plovers And Terns?, Stephanie Nefas

Dissertations and Theses

Riparian ecosystems provide habitat for birds throughout their annual cycle, yet flow regulation along major rivers like the Missouri River has reduced early successional riparian forests. Following historic flooding in 2011, set-aside areas within the Missouri National Recreational River (MNRR) were established to allow natural riparian vegetation succession on newly created sandbars. I evaluated the value of these early successional forests for birds over three breeding seasons (2018–2020) and four migration periods (2020–2021). During migration, standardized point counts documented 7,462 individual birds representing 114 species across 828 surveys. Avian diversity was positively correlated with vertical habitat complexity, with the canopy …

Forage News [2026-04], University Of Kentucky

Forage News

No abstract provided.

Forage News [2026-02], University Of Kentucky

Forage News

No abstract provided.

Forage News [2026-01], University Of Kentucky

Forage News

No abstract provided.