Life Sciences Commons^™

Three-Dimensional Evaluation Of Isodose Radiation Volumes In Cases Of Severe Mandibular Osteoradionecrosis For The Prediction Of Recurrence After Segmental Resection, Haye H Glas, Joep Kraeima, Silke Tribius, Frank K J Leusink, Carsten Rendenbach, Carmen Stromberger, Clifton D Fuller, Abdallah S R Mohamed, Stephen Y Lai, Max J H Witjes

Faculty, Staff and Student Publications

Background: Pre-operative margin planning for the segmental resection of affected bone in mandibular osteoradionecrosis (ORN) is difficult. The aim of this study was to identify a possible relation between the received RT dose, exposed bone volume and the progression of ORN after segmental mandibular resection.

Method: Patients diagnosed with grade 3-4 ORN for which a segmental resection was performed were included in the study. Three-dimensional reconstructions of RT isodose volumes were fused with postoperative imaging. The primary outcome was the recurrence of ORN after segmental resection. Subsequently, RT exposed mandibular bone volumes were calculated and the location of the bone …

Gli1 Activates Pro-Fibrotic Pathways In Myelofibrosis Fibrocytes, Taghi Manshouri, Ivo Veletic, Ping Li, C Cameron Yin, Sean M Post, Zeev Estrov

Faculty, Staff and Student Publications

Bone marrow (BM) fibrosis was thought to be induced exclusively by mesenchymal stromal cells (MSCs). However, we and others found that neoplastic fibrocytes induce BM fibrosis in myelofibrosis (MF). Because glioma-associated oncogene-1 (GLI1), an effector of the Hedgehog pathway, plays a role in the induction of BM fibrosis, we wondered whether GLI1 affects fibrocyte-induced BM fibrosis in MF. Multiplexed fluorescence immunohistochemistry analysis of MF patients' BM detected high levels of GLI1 in MF fibrocytes compared to MSCs or normal fibrocytes. Immunostaining, RNA in situ hybridization, gene expression analysis, and western immunoblotting detected high levels of GLI1 and GLI1-induced matrix metalloproteases …

Smokejumper Obituary: Burns, Richard E. (Fairbanks 1964), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Using A Network Model To Control The Spread Of An Infectious Disease On A College Campus With Contact Tracing, Christopher R. Boyette

Biology and Medicine Through Mathematics Conference

No abstract provided.

Understanding Biofilm-Phage Interactions In Mathematical Framework, Blessing Emerenini

Biology and Medicine Through Mathematics Conference

No abstract provided.

A Mathematical Model For Biological Field Effect Tranistors, Ryan M. Evans, Seulki Cho, Arvind Ballijepalli, Anthony Kearsley

Biology and Medicine Through Mathematics Conference

No abstract provided.

Optimal Intervention Strategies To Minimize Spread Of Infectious Diseases And Economic Impact On A Dynamic Small-World Network, Malindi Whyte, Danielle Dasilva

Biology and Medicine Through Mathematics Conference

No abstract provided.

A Mathematical Model Of Microtubule Assembly And Polarity In Dendrites, Anna Nelson

Biology and Medicine Through Mathematics Conference

No abstract provided.

The Effect Of Slip On The Waves Of A Free Falling Highly Viscous Film Inside A Vertical Tube, Mark S. Schwitzerlett, Ihsan Topaloglu, H. Reed Ogrosky

Biology and Medicine Through Mathematics Conference

No abstract provided.

Modeling Functional Redundancy In Microbial Community, Sandra Annie Tsiorintsoa

Biology and Medicine Through Mathematics Conference

No abstract provided.

Coffee Break, Coffee Break

Biology and Medicine Through Mathematics Conference

No abstract provided.

Plenary: Knots In Biology And Fluid Dynamics, De Witt Sumners

Biology and Medicine Through Mathematics Conference

No abstract provided.

Lunch, Lunch

Biology and Medicine Through Mathematics Conference

No abstract provided.

Mentoring Session, Mentoring

Biology and Medicine Through Mathematics Conference

No abstract provided.

Coffee Break, Coffee Break

Biology and Medicine Through Mathematics Conference

No abstract provided.

Impact Of Data Structure, Availability And Noise Distribution On Practical And Structural Identifiability Of An Seir Model, Omar Saucedo

Biology and Medicine Through Mathematics Conference

No abstract provided.

De-Coupling Cell-Autonomous And Non-Cell-Autonomous Fitness Effects Allows Solution Of The Fokker-Planck Equation For The Evolution Of Interacting Populations, Steph J. Owen

Biology and Medicine Through Mathematics Conference

No abstract provided.

Multi-Strain Epidemic Model With Infected Vaccinated And Re-Infected Recovered Population: Application To Covid-19 Pandemic, Olusegun Michael Otunuga

Biology and Medicine Through Mathematics Conference

No abstract provided.

Mathematical Modeling Of Tumor And Cancer Stem Cells Treated With Car-T Therapy And Inhibition Of Tgf-Β, Elizabeth Zollinger

Biology and Medicine Through Mathematics Conference

No abstract provided.

Gene Drives And The Consequences Of Over-Suppression, Cole Butler

Biology and Medicine Through Mathematics Conference

No abstract provided.

The Role Of Infection On Shifts In Population Cycles In A Discrete-Time Epidemic Model, Laura F. Strube, Ryan H. Hughes, Lauren M. Childs

Biology and Medicine Through Mathematics Conference

No abstract provided.

A Mathematical Model Of Innate And Adaptive Immune Responses Initiated By Superficial Burn Injury, Rachel Jennings

Biology and Medicine Through Mathematics Conference

No abstract provided.

Model Averaging In Agriculture And Natural Resources: What Is It? When Is It Useful? When Is It A Distraction?, Philip M. Dixon

Conference on Applied Statistics in Agriculture and Natural Resources

I use two examples to illustrate three methods for model averaging: using AIC weights, using BIC weights, and fully Bayesian analyses. The first example is a capture-recapture study that estimates the population size by averaging over 4 models for capture probabilities. The second is an analysis of a study of logging impacts on Curculionid weevils using a before-after-control-impact (BACI) study design. The estimated impact is averaged over 4 ecologically relevant models.

Both examples demonstrate the sensitivity of model weights, or posterior model probabilities, to the choice of prior model probabilities and prior distributions for parameters. The model averaged estimates and …

Inhibition Of Mitochondrial Complex I Reverses Notch1-Driven Metabolic Reprogramming In T-Cell Acute Lymphoblastic Leukemia., Natalia Baran, Alessia Lodi, Yogesh Dhungana, Shelley Herbrich, Meghan Collins, Shannon Sweeney, Renu Pandey, Anna Skwarska, Shraddha Patel, Mathieu Tremblay, Vinitha Mary Kuruvilla, Antonio Cavazos, Mecit Kaplan, Marc O Warmoes, Diogo Troggian Veiga, Ken Furudate, Shanti Rojas-Sutterin, Andre Haman, Yves Gareau, Anne Marinier, Helen Ma, Karine Harutyunyan, May Daher, Luciana Melo Garcia, Gheath Al-Atrash, Sujan Piya, Vivian Ruvolo, Wentao Yang, Sriram Saravanan Shanmugavelandy, Ningping Feng, Jason Gay, Di Du, Jun J Yang, Fieke W Hoff, Marcin Kaminski, Katarzyna Tomczak, R Eric Davis, Daniel Herranz, Adolfo Ferrando, Elias J Jabbour, M Emilia Di Francesco, David T Teachey, Terzah M Horton, Steven Kornblau, Katayoun Rezvani, Guy Sauvageau, Mihai Gagea, Michael Andreeff, Koichi Takahashi, Joseph R Marszalek, Philip L Lorenzi, Jiyang Yu, Stefano Tiziani, Trang Hoang, Marina Konopleva

Faculty Research 2022

T-cell acute lymphoblastic leukemia (T-ALL) is commonly driven by activating mutations in NOTCH1 that facilitate glutamine oxidation. Here we identify oxidative phosphorylation (OxPhos) as a critical pathway for leukemia cell survival and demonstrate a direct relationship between NOTCH1, elevated OxPhos gene expression, and acquired chemoresistance in pre-leukemic and leukemic models. Disrupting OxPhos with IACS-010759, an inhibitor of mitochondrial complex I, causes potent growth inhibition through induction of metabolic shut-down and redox imbalance in NOTCH1-mutated and less so in NOTCH1-wt T-ALL cells. Mechanistically, inhibition of OxPhos induces a metabolic reprogramming into glutaminolysis. We show that pharmacological blockade of OxPhos combined with …

Effects Of Administration Of A Growth Promoting Implant During The Suckling Phase Or At Weaning On Growth, Reproduction, And Ovarian Development In Replacement Heifers Grazing Native Range, Shelby L. Rosasco, Emily A. Melchior-Tiffany, Cierrah J. Kassetas, Shad H. Cox, Richard L. Dunlap, Jennifer A. Hernandez Gifford, Eric J. Scholljegerdes, Robert A. Cushman, Adam F. Summers

Roman L. Hruska U.S. Meat Animal Research Center: Reports

Management strategies utilized during pre-breeding development of replacement heifers can impact fertility and the ovarian reserve. Angus- Hereford crossbred heifers (n = 233) were utilized over a 3-yr period to determine the effects of administration of a growth promoting implant at either branding or weaning on growth, reproduction, and ovarian development. Heifer calves were randomly assigned to one of three treatments: 1) nonimplanted controls (CON; n = 79), 2) implanted at approximately 2 mo of age (average calf age = 58 d) with Synovex-C (BIMP, n = 82), or 3) implanted at approximately 7 mo of age (average calf …

Invest In Farm Water Conservation To Curtail Buy And Dry, David E. Rosenberg

Publications

The term buy-and-dry plays to the fears of farm and ranch communities. In Owens Valley, CA in the early 1900s and Palo Verde Irrigation District, CA today, wealthy urban water providers buy up water rights, dry out farms and ranches, export purchased water out of basin to growing cities, or keep water in storage to counter reservoir draw down (James, 2021). As more farmers and ranchers sell their water rights, local businesses—irrigation, farm equipment, seed, and other agricultural firms—contract. Those contractions encourage more farmers and ranchers to sell 15 their water rights and farms. And a negative feedback loop gains …

A Circular Economy Approach To Improve E-Waste Recycling In California: Economic Potential And Policy Options, Kripa Shah

Master's Projects and Capstones

The higher consumption rates of electronic devices along with their short life cycles and few repair options poses a huge challenge for E-waste industries to manage them effectively. E-waste comprises of hazardous materials and toxic constituents that can affect the environment and public health through improper disposal. However, they also contain few valuable materials that, if recovered, can reduce the dependence on virgin raw materials. Circular economy has the potential to utilize these valuable materials and gain environment and socio-economic benefits. The research explains how the adoption of a circular economy approach can help improve the E-waste recycling in California …

The Significance Of Sonic Branding To Strategically Stimulate Consumer Behavior: Content Analysis Of Four Interviews From Jeanna Isham’S “Sound In Marketing” Podcast, Ina Beilina

Student Theses and Dissertations

Purpose:
Sonic branding is not just about composing jingles like McDonald’s “I’m Lovin’ It.” Sonic branding is an industry that strategically designs a cohesive auditory component of a brand’s corporate identity. This paper examines the psychological impact of music and sound on consumer behavior reviewing studies from the past 40 years and investigates the significance of stimulating auditory perception by infusing sound in consumer experience in the modern 2020s.

Design/methodology/approach:
Qualitative content analysis of audio media was used to test two hypotheses. Four archival oral interview recordings from Jeanna Isham’s podcast “Sound in Marketing” featuring the sonic branding experts …

Full- Versus Sub-Regional Quantification Of Amyloid-Beta Load On Mouse Brain Sections, Yuu Ohno, Riley Murphy, Matthew Choi, Weijun Ou, Rachita K. Sumbria

Pharmacy Faculty Articles and Research

Extracellular accumulation of amyloid-beta (Aβ) plaques is one of the major pathological hallmarks of Alzheimer's disease (AD), and is the target of the only FDA-approved disease-modifying treatment for AD. Accordingly, the use of transgenic mouse models that overexpress the amyloid precursor protein and thereby accumulate cerebral Aβ plaques are widely used to model human AD in mice. Therefore, immunoassays, including enzyme-linked immunosorbent assay (ELISA) and immunostaining, commonly measure the Aβ load in brain tissues derived from AD transgenic mice. Though the methods for Aβ detection and quantification have been well established and documented, the impact of the size of the …

Cutting Russia's Fossil Fuel Exports: Short-Term Economic Pain For Long-Term Environmental Gain, Maksym Chepeliev, Thomas Hertel, Dominique Van Der Mensbrugghe

Department of Agricultural Economics Faculty Publications

In response to the invasion of Ukraine, most OECD countries have announced punishing sanctions against Russia. In addition to targeting financial markets and service sectors, some countries have begun to impose restrictions on exports of Russia's fossil fuels. We analyse a scenario whereby most OECD countries put major restrictions on Russia's energy exports. The short-term implications are likely to be non-trivial for the EU – Russia's largest energy export destination. Households' real income could drop by 0.7 to 1.7 percent (relative to the reference case) with energy prices growing by as much as 11 percent. But in the longer run, …