Life Sciences Commons^™

Platelets Increase The Expression Of Pd-L1 In Ovarian Cancer, Min Soon Cho, Hani Lee, Ricardo Gonzalez-Delgado, Dan Li, Tomoyuki Sasano, Qing Ma, Anil K Sood, Vahid Afshar-Kharghan

Faculty, Staff and Student Publications

The interactions between platelets and cancer cells activate platelets and enhance tumor growth. Platelets increase proliferation and epithelial-mesenchymal transition in cancer cells, inhibit anoikis, enhance the extravasation of cancer cells, and protect circulating tumor cells against natural killer cells. Here, we have identified another mechanism by which platelets dampen the immune attack on cancer cells. We found that platelets can blunt the antitumor immune response by increasing the expression of inhibitory immune checkpoint (PD-L1) on ovarian cancer cells in vitro and in vivo. Platelets increased PD-L1 in cancer cells via contact-dependent (through NF-κB signaling) and contact-independent (through TFGβR1/Smad signaling) pathways. …

Making National Cancer Institute-Designated Comprehensive Cancer Center Knowledge Accessible To Community Oncologists Via An Online Tumor Board: Longitudinal Observational Study, Maitri Kalra, Elizabeth Henry, Kelly Mccann, Meghan S Karuturi, Jean G Bustamante Alvarez, Robert Wesolowski, Sarah S Mougalian, Gregory Durm, Angel Qin, Caitlin Schonewolf, Meghna Trivedi, Avan J Armaghani, Frederick H Wilson, Wade T Iams, Anita A Turk, Praveen Vikas, Michael Cecchini, Sam Lubner, Priyadarshini Pathak, Kristen Spencer, Vadim S Koshkin, Matthew K Labriola, Catherine H Marshall, Katy E Beckermann, Marina N Sharifi, Anthony C Bejjani, Varsha Hotchandani, Samir Housri, Nadine Housri

Faculty, Staff and Student Publications

Background: Expert knowledge is often shared among multidisciplinary academic teams at tumor boards (TBs) across the country, but these conversations exist in silos and do not reach the wider oncology community.

Objective: Using an oncologist-only question and answer (Q&A) website, we sought to document expert insights from TBs at National Cancer Institute-designated Comprehensive Cancer Centers (NCI-CCCs) to provide educational benefits to the oncology community.

Methods: We designed a process with the NCI-CCCs to document and share discussions from the TBs focused on areas of practice variation on theMednet, an interactive Q&A website of over 13,000 US oncologists. The faculty translated …

Inhibition Of Mitochondrial Complex I Reverses Notch1-Driven Metabolic Reprogramming In T-Cell Acute Lymphoblastic Leukemia, Natalia Baran, Alessia Lodi, Yogesh Dhungana, Shelley Herbrich, Meghan Collins, Renu Pandey, Shraddha Patel, Mathieu Tremblay, Vinitha Mary Kuruvilla, Antonio Cavazos, Mecit Kaplan, Marc O Warmoes, Diogo Troggian Veiga, Ken Furudate, Shanti Rojas-Sutterin, Andre Haman, Yves Gareau, Anne Marinier, Helen Ma, Karine Harutyunyan, May Daher, Luciana Melo Garcia, Gheath Al-Atrash, Sujan Piya, Vivian Ruvolo, Wentao Yang, Sriram Saravanan Shanmugavelandy, Ningping Feng, Jason Gay, Di Du, Jun J Yang, Fieke W Hoff, Marcin Kaminski, Katarzyna Tomczak, R Eric Davis, Daniel Herranz, Adolfo Ferrando, Elias J Jabbour, M Emilia Di Francesco, David T Teachey, Terzah M Horton, Steven Kornblau, Katayoun Rezvani, Guy Sauvageau, Mihai Gagea, Michael Andreeff, Koichi Takahashi, Joseph R Marszalek, Philip L Lorenzi, Jiyang Yu, Stefano Tiziani, Trang Hoang, Marina Konopleva

Faculty, Staff and Student Publications

T-cell acute lymphoblastic leukemia (T-ALL) is commonly driven by activating mutations in NOTCH1 that facilitate glutamine oxidation. Here we identify oxidative phosphorylation (OxPhos) as a critical pathway for leukemia cell survival and demonstrate a direct relationship between NOTCH1, elevated OxPhos gene expression, and acquired chemoresistance in pre-leukemic and leukemic models. Disrupting OxPhos with IACS-010759, an inhibitor of mitochondrial complex I, causes potent growth inhibition through induction of metabolic shut-down and redox imbalance in NOTCH1-mutated and less so in NOTCH1-wt T-ALL cells. Mechanistically, inhibition of OxPhos induces a metabolic reprogramming into glutaminolysis. We show that pharmacological blockade of OxPhos combined with …

Mathematical Model Of Zika Epidemic In Colombia, Sethupathy Ganesan

Biology and Medicine Through Mathematics Conference

No abstract provided.

Mathematical Model Of Immune-Inflammatory Response In Covid-19 Patients, Quiyana M. Murphy

Biology and Medicine Through Mathematics Conference

No abstract provided.

Studying The Effect Of Western Diet On Atherosclerosis Risk Factors, Eric L. Scott, Rebecca Segal, Angela M. Reynolds

Biology and Medicine Through Mathematics Conference

No abstract provided.

Scale-Free Properties Influence Breathing Rhythmogenesis., Cameron Grover

Biology and Medicine Through Mathematics Conference

No abstract provided.

Cooccurrr - Applying Glcm Analysis Techniques To Non-Image Objects Such As Fitness Landscapes, Steph J. Owen

Biology and Medicine Through Mathematics Conference

No abstract provided.

Modeling The Spread Of Sars-Cov-2 Inside The Human Respiratory Tract: A Parameter Sensitivity Study, Jason Pearson

Biology and Medicine Through Mathematics Conference

No abstract provided.

Modeling Viral Resistance To Monotherapy With Monoclonal Antibody Treatment For Sars-Cov-2, Tin Phan, Carolin Zitzmann, Alan S. Perelson, Ruy M. Ribeiro, Ruian Ke

Biology and Medicine Through Mathematics Conference

No abstract provided.

Estimating Glutamate Transporter Surface Density In Mouse Hippocampal Astrocytes, Anca R. Radulescu, Annalisa Scimemi

Biology and Medicine Through Mathematics Conference

No abstract provided.

Parameter Estimation Using Nudging On The Logistic Growth Equation, Susan Rogowski

Biology and Medicine Through Mathematics Conference

No abstract provided.

Automated Fitting Of Allosteric Parameters In Receptor Oligomer Models, Spenser Wood

Biology and Medicine Through Mathematics Conference

No abstract provided.

Effect Of Myeloid-Derived Suppressor Cells On Glioblastoma-Immune Dynamics, Hannah Anderson

Biology and Medicine Through Mathematics Conference

No abstract provided.

Approximate Bayesian Computation For Generating 3d Structured Trees To Model The Pulmonary Arterial Network, Megan J. Chambers

Biology and Medicine Through Mathematics Conference

No abstract provided.

A Spatially Dependent Model For Photoreceptors In A Healthy Eye, Danielle C. Brager, Anthony Kearsley, Daniel Anderson

Biology and Medicine Through Mathematics Conference

No abstract provided.

Mathematical Modelling Of Oncolytic Virotherapy As A Cancer Treatment, Maila Hallare, Iordanka Panayotova

Biology and Medicine Through Mathematics Conference

No abstract provided.

A Within-Host Modeling Framework For Sars-Cov-2 Infection To Support Vaccine Strategies, Morgan Rose, Rachel Jennings, Jeffry Schroeter

Biology and Medicine Through Mathematics Conference

No abstract provided.

Osmotic Perturbation Promotes Competition Between Bacteria In Gut, Shaikh Obaidullah

Biology and Medicine Through Mathematics Conference

No abstract provided.

Seasonality And The Dynamics Of Mycobacterium Ulcerans Transmission., Kwame E. Osei Bonsu

Biology and Medicine Through Mathematics Conference

No abstract provided.

Mathematical Modeling Of Brain Cancer Growth Using A Level-Set Method, Gbocho M. Terasaki

Biology and Medicine Through Mathematics Conference

No abstract provided.

Sensitivity And Bifurcation Analysis Of Tuberculosis Progression, Wenjing Zhang

Biology and Medicine Through Mathematics Conference

No abstract provided.

Thoracoabdominal Asynchrony In A Virtual Preterm Infant: Computational Modeling And Analysis, Richard R. Foster, Laura Ellwein Fix

Biology and Medicine Through Mathematics Conference

No abstract provided.

Spatial Patterning Of Predator-Prey Distributions Arising From Prey Defense, Evan C. Haskell, Jonathan Bell

Biology and Medicine Through Mathematics Conference

No abstract provided.

An Ode Model For Predicting Pediatric Patient Pain In Scd Based On Patient Sleep Data, Quindel Jones, Rebecca Segal, Angela M. Reynolds, Cecelia Valrie, Reginald Mcgee

Biology and Medicine Through Mathematics Conference

No abstract provided.

A. Poster Session, 1. Poster

Biology and Medicine Through Mathematics Conference

No abstract provided.

Evaluating The Practical Identifiability Of A Malaria Model To Assess Conversion To Transmissible Stages, Anthony Raymond Krueger, Damie Pak, Megan Greischar, Lauren Childs

Biology and Medicine Through Mathematics Conference

No abstract provided.

Genetically Explicit Model May Explain Multigenerational Control Of Emergent Turing Patterns In Hybrid Mimulus, Emily Simmons

Biology and Medicine Through Mathematics Conference

No abstract provided.

Bioeconomic Analysis In A Predator-Prey System With Harvesting: A Case Study In The Chesapeake Bay Fisheries, Iordanka Panayotova, Maila Hallare

Biology and Medicine Through Mathematics Conference

No abstract provided.

Computational Model Of Mutant Arpp Protein Aggregation And Diffusion And Its Impact On Calcium Dynamics And Stress Responses Using Neuron., Gaby Clarke

Biology and Medicine Through Mathematics Conference

No abstract provided.