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Articles 51811 - 51840 of 256002

Full-Text Articles in Life Sciences

Mutational Activation Of The Nrf2 Pathway Upregulates Kynureninase Resulting In Tumor Immunosuppression And Poor Outcome In Lung Adenocarcinoma, Johannes F Fahrmann, Ichidai Tanaka, Ehsan Irajizad, Xiangying Mao, Jennifer B Dennison, Julian Casabar, Qian Peng, Muge Celiktas, Jody V Vykoukal, Soyoung Park, Ayumu Taguchi, Oliver Delgado, Satyendra C Tripathi, Hiroyuki Katayama, Luisa Maren Solis Soto, Jaime Rodriguez-Canales, Carmen Behrens, Ignacio Wistuba, Samir Hanash, Edwin J Ostrin May 2022

Mutational Activation Of The Nrf2 Pathway Upregulates Kynureninase Resulting In Tumor Immunosuppression And Poor Outcome In Lung Adenocarcinoma, Johannes F Fahrmann, Ichidai Tanaka, Ehsan Irajizad, Xiangying Mao, Jennifer B Dennison, Julian Casabar, Qian Peng, Muge Celiktas, Jody V Vykoukal, Soyoung Park, Ayumu Taguchi, Oliver Delgado, Satyendra C Tripathi, Hiroyuki Katayama, Luisa Maren Solis Soto, Jaime Rodriguez-Canales, Carmen Behrens, Ignacio Wistuba, Samir Hanash, Edwin J Ostrin

Faculty, Staff and Student Publications

Activation of the NRF2 pathway through gain-of-function mutations or loss-of-function of its suppressor KEAP1 is a frequent finding in lung cancer. NRF2 activation has been reported to alter the tumor microenvironment. Here, we demonstrated that NRF2 alters tryptophan metabolism through the kynurenine pathway that is associated with a tumor-promoting, immune suppressed microenvironment. Specifically, proteomic profiles of 47 lung adenocarcinoma (LUAD) cell lines (11 KEAP1 mutant and 36 KEAP1 wild-type) revealed the tryptophan-kynurenine enzyme kynureninase (KYNU) as a top overexpressed protein associated with activated NRF2. The siRNA-mediated knockdown of NFE2L2, the gene encoding for NRF2, or activation of the NRF2 …

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Boxed Lunches, Lunch May 2022

Boxed Lunches, Lunch

Biology and Medicine Through Mathematics Conference

No abstract provided.

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Mathematics Of A Single-Locus Model For Assessing The Impacts Of Pyrethroid Resistance And Temperature On Population Abundance Of Malaria Mosquitoes, Jemal Mohammed-Awel May 2022

Mathematics Of A Single-Locus Model For Assessing The Impacts Of Pyrethroid Resistance And Temperature On Population Abundance Of Malaria Mosquitoes, Jemal Mohammed-Awel

Biology and Medicine Through Mathematics Conference

No abstract provided.

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Mixed Mode Oscillations In Three-Timescale Coupled Morris-Lecar Neurons, Ngocanh Phan, Yangyang Wang May 2022

Mixed Mode Oscillations In Three-Timescale Coupled Morris-Lecar Neurons, Ngocanh Phan, Yangyang Wang

Biology and Medicine Through Mathematics Conference

No abstract provided.

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Modeling The Cardiovascular Dynamics Of Postural Orthostatic Tachycardia Syndrome, Justen Geddes May 2022

Modeling The Cardiovascular Dynamics Of Postural Orthostatic Tachycardia Syndrome, Justen Geddes

Biology and Medicine Through Mathematics Conference

No abstract provided.

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Modeling Acute And Chronic Vascular Adaptations To A Major Arterial Occlusion, Erin O. Zhao May 2022

Modeling Acute And Chronic Vascular Adaptations To A Major Arterial Occlusion, Erin O. Zhao

Biology and Medicine Through Mathematics Conference

No abstract provided.

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Mathematical Model Of Subthalamic Nucleus Neuron - Characteristic Activity Patterns And Bifurcation Analysis, Choongseok Park, Sungwoo Ahn, Leonid Rubchinsky May 2022

Mathematical Model Of Subthalamic Nucleus Neuron - Characteristic Activity Patterns And Bifurcation Analysis, Choongseok Park, Sungwoo Ahn, Leonid Rubchinsky

Biology and Medicine Through Mathematics Conference

No abstract provided.

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Modeling The Dynamics Of Usutu Virus Infection In Birds, Nora G. Heitzman-Breen May 2022

Modeling The Dynamics Of Usutu Virus Infection In Birds, Nora G. Heitzman-Breen

Biology and Medicine Through Mathematics Conference

No abstract provided.

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Universality And Synchronization In Complex Quadratic Networks (Cqns), Anca R. Radulescu, Danae Evans May 2022

Universality And Synchronization In Complex Quadratic Networks (Cqns), Anca R. Radulescu, Danae Evans

Biology and Medicine Through Mathematics Conference

No abstract provided.

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Epidemiological Assessment Of Wolbachia-Based Biocontrol For Reduction Of Dengue Morbidity, Olga Vasilieva, Oscar E. Escobar, Hector J. Martinez, Pierre-Alexandre Bliman, Yves Dumont May 2022

Epidemiological Assessment Of Wolbachia-Based Biocontrol For Reduction Of Dengue Morbidity, Olga Vasilieva, Oscar E. Escobar, Hector J. Martinez, Pierre-Alexandre Bliman, Yves Dumont

Biology and Medicine Through Mathematics Conference

No abstract provided.

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Mechanical Parameters Fitting For Layer-Reduced Umbilical Arteries Used For Grafting, Kun Gou May 2022

Mechanical Parameters Fitting For Layer-Reduced Umbilical Arteries Used For Grafting, Kun Gou

Biology and Medicine Through Mathematics Conference

No abstract provided.

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Mathematical Model Of Triple-Negative Breast Cancer In Response To Combination Chemotherapies, Angelica Davenport, Yun Lu, Carlos Gallegos, Adriana Massicano, Katherine Heinzman, Patrick Song, Anna Sorace, Nick Cogan May 2022

Mathematical Model Of Triple-Negative Breast Cancer In Response To Combination Chemotherapies, Angelica Davenport, Yun Lu, Carlos Gallegos, Adriana Massicano, Katherine Heinzman, Patrick Song, Anna Sorace, Nick Cogan

Biology and Medicine Through Mathematics Conference

No abstract provided.

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Model Of Quarantine Implementation In An Animal Shelter For Canine Distemper Outbreak, Virginia Parkman, Nick Cogan May 2022

Model Of Quarantine Implementation In An Animal Shelter For Canine Distemper Outbreak, Virginia Parkman, Nick Cogan

Biology and Medicine Through Mathematics Conference

No abstract provided.

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Coffee Break, Coffee Break May 2022

Coffee Break, Coffee Break

Biology and Medicine Through Mathematics Conference

No abstract provided.

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Plenary: Cardiovascular Models In Vascular Disease, Mette Olufsen May 2022

Plenary: Cardiovascular Models In Vascular Disease, Mette Olufsen

Biology and Medicine Through Mathematics Conference

No abstract provided.

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Seasonal Migration Distance Varies With Natal Dispersal And Predicts Parasitic Infection In Song Sparrows, Tosha R. Kelly, Heather L. Macgillivray, Yanina Sarquis-Adamson, Matthew J. Watson, Keith A. Hobson, Elizabeth A. Macdougall-Shackleton May 2022

Seasonal Migration Distance Varies With Natal Dispersal And Predicts Parasitic Infection In Song Sparrows, Tosha R. Kelly, Heather L. Macgillivray, Yanina Sarquis-Adamson, Matthew J. Watson, Keith A. Hobson, Elizabeth A. Macdougall-Shackleton

Biology Publications

Seasonal migration and natal dispersal represent the major large-scale movements in the lives of animals. Individuals that are relatively prone to movement and exploration might thus be more likely to disperse and also to migrate farther. Such movement might be either negatively associated with parasitic infection (if infection prevents hosts from successful long-distance migration) or positively associated (e.g. if longer-distance migrants encounter more abundant or more diverse parasites). We examined whether natal dispersal tendency predicts seasonal migration distance in song sparrows (Melospiza melodia) and whether migration distance predicts infection with bloodborne parasites upon arrival at the breeding grounds. …

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In Situ Observations Of Fish Attraction To Light-Emitting Diodes On An Undersea Observation Deck, Makoto Tomiyasu, Yoko Tanouchi, Yasuzumi Fujimori, Minato Kaji, Takuma Hayashi, Naoto Matsubara, Hiroki Yasuma, Susumu Shimizu, Seiji Katakura May 2022

In Situ Observations Of Fish Attraction To Light-Emitting Diodes On An Undersea Observation Deck, Makoto Tomiyasu, Yoko Tanouchi, Yasuzumi Fujimori, Minato Kaji, Takuma Hayashi, Naoto Matsubara, Hiroki Yasuma, Susumu Shimizu, Seiji Katakura

Journal of Marine Science and Technology–Taiwan

Many fisheries employ fishing lights to manipulate the behaviors of target fish and to attract them toward the light; however, relatively few long-time observations of fish attraction have been performed in the field. Here, an underwater observation deck was used to examine the differences in the fish-attracting effect of light-emitting diode (LED) lights on the number of attracted fish and on their behavior in the field, using white-edged rockfish as the target species. A total of 604 ± 324, 307 ± 203 and 171 ± 106 white-edged rockfish individuals were attracted to the observation window when it was illuminated with …

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Inter-Annual Variability In Growth And Maturation Of The Swordtip Squid Uroteuthis Edulis In Yilan Bay Off Northeastern Taiwan, Jing-Yu Chen, Tzu-Yun Ching, Chih-Shin Chen May 2022

Inter-Annual Variability In Growth And Maturation Of The Swordtip Squid Uroteuthis Edulis In Yilan Bay Off Northeastern Taiwan, Jing-Yu Chen, Tzu-Yun Ching, Chih-Shin Chen

Journal of Marine Science and Technology–Taiwan

The swordtip squid Uroteuthis edulis, distributed in the temperate and tropical neritic waters in the Indo-Pacific region, is a crucial component of marine ecosystems and is a target species of fisheries in the Northwest Pacific. Although studies have elucidated the growth and maturation of the squid in the southern East China Sea (ECS) shelf, few have assessed the population biology of the squid in waters in the vicinity of the southern ECS. We collected samples of swordtip squid from a trawler in Yilan Bay (YLB) between January 2011 and December 2012 to examine the growth and maturation of the squid …

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Study On The Improved Radiation Boundary Conditions Based On The Quadratic B-Spline Rankine Panel Method, Ming-Chung Fang, Chun-Hsien Wu May 2022

Study On The Improved Radiation Boundary Conditions Based On The Quadratic B-Spline Rankine Panel Method, Ming-Chung Fang, Chun-Hsien Wu

Journal of Marine Science and Technology–Taiwan

This study presents a higher-order Rankine source method that is based on a biquadratic B-spline scheme with an improved radiation boundary condition. This method solves flow problems under all conditions, where , including the undercritical condition ( < 0.25); this condition is present when a ship undergoes slow translational motion. The proposed method is thus more flexible than the many Rankine-source models in the literature that are applicable only to the overcritical condition ( > 0.25). Specifically, the improved radiation boundary condition is derived from upstream Seto radiation boundary conditions and by incorporating the Rayleigh damping distribution over a free surface; the improved condition is explicit and efficient for solving flow problems. In evaluations, the proposed method yields accurate solutions for unsteady flows, which are produced by an oscillating, translationally moving submerged singularity. The method is also compared …

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Sensitive Analysis Of The Static Response Of Compliant Vertical Access Risers, Fuheng Li, Haiyan Guo, Xiaomin Li, Honglu Gu May 2022

Sensitive Analysis Of The Static Response Of Compliant Vertical Access Risers, Fuheng Li, Haiyan Guo, Xiaomin Li, Honglu Gu

Journal of Marine Science and Technology–Taiwan

Compliant vertical access risers (CVARs) are considered as efficient and robust alternative options to achieve cost efficiency and safety. Design uncertainties emerge owing to the limited understanding of the effects of various parameters related to the structural properties and marine loads. In this paper, a reasonable three-dimensional (3D) numerical model of CVAR with internal flow is presented based on the slender rod theory. Accordingly, the finite element method combined with a Newton-Raphson scheme is employed to discretize and solve the equations. A sensitivity analysis is performed to investigate the influence of the structural and external load parameters on the static …

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Influence Of Boundary Conditions And Internal Fluid Types On Dynamic Characteristics Of A Deepwater Riser, Lei Guo, Zong-Ming Zhu, Zhong-Jian Pan, Zhi-Ming Guo May 2022

Influence Of Boundary Conditions And Internal Fluid Types On Dynamic Characteristics Of A Deepwater Riser, Lei Guo, Zong-Ming Zhu, Zhong-Jian Pan, Zhi-Ming Guo

Journal of Marine Science and Technology–Taiwan

Deepwater Steel Catenary Riser (DSCR) is the key structure of oil and gas production system in the ocean. To design an optimized DSCR system, the dynamic characteristics of the DSCR are analyzed by setting some different boundary condi-tions and internal fluid types. The main vibration mode of the DSCR is found orthogonal to both mass and stiffness according to the normalization condition of the main mode, and then the regular mode function and the jth order principal stiffness Kpj are obtained. Under different initial conditions, the transverse responses of DSCR represented by regular coordinates under arbitrary excitation are obtained. Then, …

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Variance Of Td-Mosaic Dual-Vortex Interactions Between In-Fa And Cempaka (2021) In The North Pacific, Tsorng-Lin Chia, Guang-Yang Pan, Ji-Chyun Liu May 2022

Variance Of Td-Mosaic Dual-Vortex Interactions Between In-Fa And Cempaka (2021) In The North Pacific, Tsorng-Lin Chia, Guang-Yang Pan, Ji-Chyun Liu

Journal of Marine Science and Technology–Taiwan

A study of the different types of dual-vortex interactions or “Fujiwara effects” between two storms is crucial for considerably improving weather forecasts. This study combined remote sensing images, empirical formulas based on the possibility of storm interaction (Liou–Liu formula), and vector addition techniques to accurately analyze In-Fa and Cempaka typhoons and the surrounding weather patterns during the 2021 typhoon season in the North Pacific. Although the distance separating the typhoons In-Fa and Cempaka was 1,800–2,040 km, the influence of middle air flow and a tropical depression (TD) caused a "vector superposition TD-mosaic double-vortex" interaction between the two typhoons. Therefore, this …

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Optimal Deployment Of Flood Emergency Response Materials Under Stochastic Demands, Shangyao Yan, Jenn-Rong Lin, Chia-Fu Ku May 2022

Optimal Deployment Of Flood Emergency Response Materials Under Stochastic Demands, Shangyao Yan, Jenn-Rong Lin, Chia-Fu Ku

Journal of Marine Science and Technology–Taiwan

This study aims to develop a planning model for the deployment of flood emergency response materials under stochastic demands. For ease of modeling, a deterministic demand model is first proposed, from which the stochastic model is further extended. These models are used to determine the allocation of materials the transport truck routes and distribution of the stockpiled materials to emergency sites. The models are formulated as multiple integer network flow problems with special side constraints which are characterized as NP-hard in terms of optimization. To solve the complicated stochastic model efficiently, we also develop a solution algorithm based on a …

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Asset Values Of Trees Vary Among Age And Condition, Aidan Castricone May 2022

Asset Values Of Trees Vary Among Age And Condition, Aidan Castricone

Biology Student Scholarship

Trees are utilized everywhere for visual, physical or functional means with an example being on Providence College campus. We have 1,403 trees part of an inventory and management plan. As part of this plan that was updated this past December 2021 each tree has an asset value calculated with consideration of the size, species, condition, and location. What was not clear in the management plan was whether one factor held more weight in the calculated value compared to another factor. This research focuses on the influence that the age and condition of the tree have on the tree asset value. …

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Efficacy And Timing Of Application Of Fungicides, Biofungicides, Host-Plant Defense Inducers, And Fertilizer To Control Phytophthora Root Rot Of Flowering Dogwoods In Simulated Flooding Conditions In Container Production, Krishna Neupane, Bhawana Ghimire, Fulya Baysal-Gurel May 2022

Efficacy And Timing Of Application Of Fungicides, Biofungicides, Host-Plant Defense Inducers, And Fertilizer To Control Phytophthora Root Rot Of Flowering Dogwoods In Simulated Flooding Conditions In Container Production, Krishna Neupane, Bhawana Ghimire, Fulya Baysal-Gurel

Agricultural and Environmental Sciences Faculty Research

Phytophthora root rot caused by Phytophthora cinnamomi Rands is one of the major diseases of flowering dogwoods (Cornus florida L.). The severity of root rot disease increases when the plants are exposed to flooding conditions. A study was conducted to determine the efficacy and timing of application of different fungicides, biofungicides, host plant defense inducers, and fertilizer to manage Phytophthora root rot in month-old seedlings in simulated flooding events for 1-, 3-, and 7- days. Preventative treatments were drench applied 3 weeks and 1 week before flooding whereas curative treatments were applied 24 hrs. after flooding. Dogwood seedlings were inoculated …

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Comparative Analysis Of Three Bait Types In Deep-Set Pelagic Longline Gear In The Equatorial Atlantic Ocean, Tiago Hilário Pedrosa Campello, Lucas Eduardo Comassetto, Humberto Gomes Hazin, Jose Carlos Pacheco Dos Santos, Dave Kerstetter, Fábio Hissa Vieira Hazin May 2022

Comparative Analysis Of Three Bait Types In Deep-Set Pelagic Longline Gear In The Equatorial Atlantic Ocean, Tiago Hilário Pedrosa Campello, Lucas Eduardo Comassetto, Humberto Gomes Hazin, Jose Carlos Pacheco Dos Santos, Dave Kerstetter, Fábio Hissa Vieira Hazin

Marine & Environmental Sciences Faculty Articles

The choice of bait is one of the fisheries tactics used to increase selectivity for particular target species. The performance of three bait types (mackerel, sardine, squid) was evaluated with a commercial vessel operating in the Equatorial Atlantic Ocean using the deep-set pelagic longline deployment method to target large yellowfin and bigeye tunas. The effect of different factors and covariates on the Capture per Effort Unit - CPUE was evaluated through Generalized Linear Models (GLM). In 121 experimental sets using three bait types, 2385 individuals of the two target species were captured, 1166 yellowfin tuna and 1219 bigeye tuna. The …

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Super-Resolution Visualization Of Chromatin Loop Folding In Human Lymphoblastoid Cells Using Interferometric Photoactivated Localization Microscopy., Zofia Parteka-Tojek, Jacqueline Jufen Zhu, Byoungkoo Lee, Karolina Jodkowska, Ping Wang, Jesse Aaron, Teng-Leong Chew, Krzysztof Banecki, Dariusz Plewczynski, Yijun Ruan May 2022

Super-Resolution Visualization Of Chromatin Loop Folding In Human Lymphoblastoid Cells Using Interferometric Photoactivated Localization Microscopy., Zofia Parteka-Tojek, Jacqueline Jufen Zhu, Byoungkoo Lee, Karolina Jodkowska, Ping Wang, Jesse Aaron, Teng-Leong Chew, Krzysztof Banecki, Dariusz Plewczynski, Yijun Ruan

Faculty Research 2022

The three-dimensional (3D) genome structure plays a fundamental role in gene regulation and cellular functions. Recent studies in 3D genomics inferred the very basic functional chromatin folding structures known as chromatin loops, the long-range chromatin interactions that are mediated by protein factors and dynamically extruded by cohesin. We combined the use of FISH staining of a very short (33 kb) chromatin fragment, interferometric photoactivated localization microscopy (iPALM), and traveling salesman problem-based heuristic loop reconstruction algorithm from an image of the one of the strongest CTCF-mediated chromatin loops in human lymphoblastoid cells. In total, we have generated thirteen good quality images …

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Distinct Mirnas Associated With Various Clinical Presentations Of Sars-Cov-2 Infection., Qiqi Zeng, Xin Qi, Junpeng Ma, Fang Hu, Xiaorui Wang, Hongyu Qin, Mengyang Li, Shaoxin Huang, Yong Yang, Yixin Li, Han Bai, Meng Jiang, Doudou Ren, Ye Kang, Yang Zhao, Xiaobei Chen, Xi Ding, Di Ye, Yankui Wang, Jianguo Jiang, Dong Li, Xi Chen, Ke Hu, Binghong Zhang, Bingyin Shi, Chengsheng Zhang May 2022

Distinct Mirnas Associated With Various Clinical Presentations Of Sars-Cov-2 Infection., Qiqi Zeng, Xin Qi, Junpeng Ma, Fang Hu, Xiaorui Wang, Hongyu Qin, Mengyang Li, Shaoxin Huang, Yong Yang, Yixin Li, Han Bai, Meng Jiang, Doudou Ren, Ye Kang, Yang Zhao, Xiaobei Chen, Xi Ding, Di Ye, Yankui Wang, Jianguo Jiang, Dong Li, Xi Chen, Ke Hu, Binghong Zhang, Bingyin Shi, Chengsheng Zhang

Faculty Research 2022

MicroRNAs (miRNAs) have been shown to play important roles in viral infections, but their associations with SARS-CoV-2 infection remain poorly understood. Here, we detected 85 differentially expressed miRNAs (DE-miRNAs) from 2,336 known and 361 novel miRNAs that were identified in 233 plasma samples from 61 healthy controls and 116 patients with COVID-19 using the high-throughput sequencing and computational analysis. These DE-miRNAs were associated with SASR-CoV-2 infection, disease severity, and viral persistence in the patients with COVID-19, respectively. Gene ontology and KEGG pathway analyses of the DE-miRNAs revealed their connections to viral infections, immune responses, and lung diseases. Finally, we established …

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The Impacts Of Ph On Biodiversity In Marine Environments, Matthew Rock May 2022

The Impacts Of Ph On Biodiversity In Marine Environments, Matthew Rock

Biology Student Scholarship

Climate change continues to impact each and every environment on Earth due to rising levels of greenhouse gasses. CO2 is the most pervasive of these gasses, and when mixed with seawater it creates carbonic acid increasing the pH of water. Ocean acidification has led to large-scale die-offs of more sensitive marine species like coral; therefore, this project serves to evaluate the interaction between pH and the biodiversity of coastal marine environments. BIO 340 final project

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Bird Nesting Trends In Massachusetts, Dieter Rodriguez May 2022

Bird Nesting Trends In Massachusetts, Dieter Rodriguez

Biology Student Scholarship

Bird nesting data has long been documented for various species across the United States. While trends between temperature changes or precipitation on bird nesting have been studied for particular species, studies done on the effects of temperature due to climate change on bird nesting on the broader state level are lacking. Using bird nesting data and average annual temperature data for Massachusetts collected over a ten year period, I assessed the effects of temperature changes over time on bird nesting attempts and total eggs laid for all documented species within the state. BIO 340 final project

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