Life Sciences Commons^™

G-Quadruplex Dna-Driven Genomic Instability Under Ber Loss, Addison Belick, Claryssa Gutierrez, Joslynn Rosas, Andrea Vargas

Posters - 2026

Base Excision Repair (BER) is a cellular tool that can repair damaged DNA (Hindi et al., 2022, Cellular and Molecular Life Sciences). G-quadruplexes (G4s) are unique 4-stranded structures in DNA or RNA that are rich in guanine (Gray et al., 2023, Nat. Chem. Biol). The purpose of this study is to understand whether BER contributes to the removal of G4s in DNA. This will determine if the BER-deficient yeast is more sensitive to treatment with G4-binding drugs than the BER-proficient yeast. We will replace the APN1 gene in the yeast genome with the URA3 gene, because the wild type yeast …

Effects Of Mycoplasma Pneumoniae Cards Toxin On Lung Fibroblast Function, Shuri Magdalene

Posters - 2026

Mycoplasma pneumoniae is a common respiratory pathogen whose virulence depends largely on the community-acquired respiratory distress syndrome (CARDS) toxin, a 591-amino-acid ADP-ribosylating protein¹. CARDS toxin induces immune responses²˒³, causes vacuolation in lung epithelial cells, and contributes to the inflammatory and pathological features of pneumonia. IMR-90 fibroblasts. IMR-90 cells are human fetal lung fibroblasts widely used to study responses to inflammatory signals, extracellular matrix production, and lung injury or repair. Rationale. Fibroblasts are key drivers of tissue remodeling and fibrosis during lung injury. Defining how CARDS toxin influences fibroblast programs in inflammation, cell-cycle control, and matrix remodeling²˒³ will clarify how M. …

Evaluating The Effects Of Akt Knockdown And Everolimus Treatment On Ewing Sarcoma, Arisha Arif, Alfie Barcenez, Nicole Vanegas-Riddick

Posters - 2026

The purpose of this study is to use the gene AKT1, due to the interest in AKT1’s role in cancer cell proliferation, and the drug Everolimus, to determine if combined targeted therapy works as a more efficient therapeutic approach. We hypothesize that the knockdown of AKT1 will increase the sensitivity of Ewing sarcoma cells to Everolimus, resulting in reduced proliferation and/or survival compared to drug treatment alone. This would suggest that AKT1 normally protects cells from drug-induced stress. Ewing Sarcoma has been connected to chromosomal translocations and most common in pediatric patients. It is most often treated with chemotherapy and …

Impact Of Ashwagandha Treatment On Cytokine Production And Macrophage Differentiation Into Thp-1 Cells, Betsi Diaz Chavarin, Aditi Kumar

Posters - 2026

Inflammation is a critical biological response that enables the immune system to react to infections, injuries, or stressful situations. However, chronic or excessive inflammation can lead to tissue damage and contribute to a wide range of diseases, including neurodegenerative disorders, metabolic syndromes, and immune dysregulation. 3,4 Interleukin-1 beta (IL-1β) is a key pro-inflammatory cytokine that plays a central role in initiating and amplifying the immune response. 1,2 It is primarily produced by activated monocytes and macrophages in response to stimuli such as pathogens or stress signals. In addition, IL-1β acts on the hypothalamus to induce fever, which creates an environment …

Sirna Knockdown Of Rptor Alters Gene Expression In Ewing Sarcoma Cells, Sergio Cipriano, David Leavitt, Michael Oliva, Liam Valdez

Posters - 2026

Ewing sarcoma is a highly aggressive cancer that primarily affects children and young adults. Although treatment options exist, many patients do not respond effectively, showing the need for improved targeted therapies¹. RPTOR is a key in mTORC1 complex which regulates cell growth, proliferation, and survival². LY2874455 is a selective pan-FGFR inhibitor that targets growth factor signaling pathways involved in tumor progression³, and FGFR signaling interacts with pathways such as mTOR, making it a potential target for combination therapies. We hypothesized that silencing RPTOR in Ewing sarcoma cells would disrupt mTOR signaling and alter expression of genes linked to cell survival …

Take A Hit? Take A Hit: Quantifying Cell Death In E-Cigarette Exposed Bronchial Epithelial Cells Following Cards Toxin Treatment, Truman Havrda, Hannah Jiron, Sierra Trevino

Posters - 2026

The rapid rise of e-cigarette use among young adults has created a significant public health challenge, as the popularity of "vaping" has grown faster than our understanding of its long term cellular consequences. Current research indicates that e-cigarette vapor (ECV) induce high levels of oxidative stress and impair the lungs' ability to clear bacterial pathogens. Furthermore, ECV exposure upregulates specific receptors on the surface of airway cells, essentially making it easier for bacteria to adhere to and infect the lungs. While we know that both e-liquids and vapor trigger inflammatory responses and cytotoxicity, there is limited data on how these …

Beluga Buddies: The Preferred Social Network Of Belugas In Managed Care, Valery Marinelarena, Diamond Garcia

Posters - 2026

Belugas societies are not fixed  and group composition is everchanging. Group composition can also influence behavior. This study aims to examine the preferred social networks and the role age plays in the behavioral diversity within a group of managed care belugas housed at Sea World San Antonio. Results Supported TYO had a preferred, non-random social network and ATL performing more chinslaps than TYO.

Does Social Grouping Influence Object Play By Belugas?, Javier Obiltas, Phillip Clayton

Posters - 2026

Play is defined as voluntary behavior that differs from functional behaviors and typically occurs in low-stress environments. In cetaceans, object play has been linked to development, motor skill practice, and social learning. Play behavior is an important factor of development in belugas, because belugas are social animals that live and interact within groups, the composition of these groups or "groupings" might influence their play behaviors. Understanding how said groupings may affect the play rates may help researchers better understand the development of behavior and social dynamics of the beluga groupings. The purpose of this study was to see whether grouping …

Does Shape Matter?: How Salamander Head Morphology Shifts Based On Environment, Caitlyn Pinaga, Naomi Ramirez, Sonia Cerrillo

Posters - 2026

Groundwater salamanders of the genus Eurycea represent a diverse group of amphibians inhabiting the aquifer systems of central Texas, where both surface-dwelling and fully subterranean species coexist. Subterranean habitats impose extreme selective pressures, including complete darkness, limited nutrient availability, and stable environmental conditions, which drive convergent morphological traits such as eye reduction or loss, decreased pigmentation, and elongation of appendages. A key evolutionary pattern seen in these systems is sensory compensation, in which the reduction of one sensory modality, in this case vision, is accompanied by the enhancement of others. In aquatic salamanders, this often involves expansion of the lateral …

Smell Over Sight: Determining Levels Of Olfactory Gene Expression Between Surface And Subterranean Eurycea Salamanders, Sonia Cerrillo, Iliana Melendez, Naomi Ramirez

Posters - 2026

In the karst aquifers of central Texas, including the Edwards and Trinity systems, organisms live in an environment defined by constant temperatures, total darkness, and scarce food resources. These conditions have driven the evolution of salamanders in the genus Eurycea, particularly those that have adapted to subterranean life. Cave-dwelling species like Eurycea rathbuni exhibit hallmark “blind salamander” traits, including educed eyes, loss of pigmentation, and flattened head morphology. In contrast, surface-dwelling relatives such as Eurycea nana and Eurycea sosorum retain fully developed eyes and pigmentation, while some species like Eurycea latitans display both surface and subterranean forms across different populations.

Gene Expression And Apoptotic Responses To Panobinostat Treatment And Yap Knockdown In Ewing Sarcoma Cells, Luna Collazo-Garcia, Alejandra Favela Santos, Madeline Torres-Salazar, Isabella Toscano

Posters - 2026

Ewing sarcoma is an aggressive pediatric cancer driven by abnormal gene expression caused by the EWS-FLI1 fusion protein

Usually treated with intensive treatments such as chemotherapy and radiation

Outcomes remain poor for metastatic disease, highlighting the need for new therapeutic strategies

The Hippo signaling pathway regulates cell proliferation and survival through the transcriptional co-activator YAP1

Sustainable Mitigation Of Microplastic Pollutants Using Native Plant Species, Antonio De Jesus Martinez De La Rosa, Emily Lancaster

Research Papers

Microplastics (MPs) are defined as small plastic particles that come from the degradation of plastics [Ziani et al. 2023], that hold a regular or irregular shape, ranging from 1μm to 5 mm [Campanale et al. 2025]. This diminutive size makes them virtually impossible to remove once released into the environment[Lee et al. 2023]. Furthermore, biological, chemical, and physical processes break MP's further down in the environment, causing them to exist in nano-level sizes (1nm-1μm) [Lee et al. 2023], further exacerbating their threat to critical habitats. However, recent studies have shown MP contamination expands beyond the natural environment as recent studies …

Biol 210: Nutrition (Syllabus), Sam Newberry Ph.D.

School of Arts & Sciences

This syllabus was developed by SUNY Geneseo Professor Sam Newberry during the spring 2026 semester.

Course Learning Objectives:

Students who are active participants and complete course requirements will be able to: 

1. Demonstrate familiarity with nutrients, their food sources, their functions, and signs and symptoms of deficiency or excess.
2. Demonstrate familiarity with biological, psychological, social and cultural factors that influence human diet and nutrition.
3. Describe and explain in class discussion and on exams the relationship between diet and health, particularly for selected public health issues.
4. Demonstrate familiarity with nutritional guidelines used in the United States, and the challenges of establishing such …

Synthesis Of Copper-Phenanthroline Complexes: A Solvothermal-Compatible Approach For The Exploration Of Metal Complexes, Yunping Zhoujin, Michael Anim Safo, Navindra Keerthisinghe, Mark D. Smith, Sophya Garashchuk, Hans Conrad Zur Loye

Faculty Publications

Inorganic–organic hybrid materials have been widely investigated for their applications in catalysis, optics, magnetism, and biomedicine. Copper halide complexes are of particular interest due to their structural diversity and physicochemical properties. Conventional crystal growth approaches, such as slow evaporation and hydro(solvo)thermal synthesis, typically require extended reaction times and often favor thermodynamically stable phases. In this study, we prepared ten copper-phenanthroline halide (X = Cl, Br, and I) complexes using both traditional hydrothermal reactions and microwave-assisted hydrothermal methods and obtained [CuI(C₁₂H₈N₂)₂][I₃], [C₁₂H₉N₂][CuI₂]·(H_{2 …}

Teeth That Tell Time: Elemental Analysis From Shark Teeth, Gisele-Elizabeth Perez, David Turner

Research Papers

Sharks (Chondrichthyes) have hunted in the oceans for over 400 million years, their teeth leaving history behind, constantly becoming a part of the fossilization process (Worm et al. 2013). Their survival throughout 5 major extinctions is due to their ability to adapt easily with slow metabolism, a wide range of diet, and an efficient physiology. Shark teeth are vital to the hunting and consumption of their prey, making it a point for scientists to study them. Their tooth minerals contain fluorapatite in their enameloid, and dentin in the “root” of the tooth, with extinct species containing dentin and hydroxyapatite in …

Detecting And Managing Plant-Parasitic Nematodes On Peanut In South Carolina, Zachary Dantzler, Dan Arco, Joe E. Varn, Shelby Hammond, John D. Mueller

Peanuts

Several species of nematodes cause significant yield losses on peanuts in the southern United States (Table 1). Among row crops, peanuts are unique because nematodes can damage peanuts at two different growth stages. First, nematodes can affect the emerging radicle and secondary roots, causing reductions in water and nutrient uptake, and subsequently causing stunting or chlorosis. In many cases, the most significant impact of nematodes on peanut is a decrease in grade caused directly by the nematodes feeding on peanut pegs and shells. These wounds allow pathogenic fungi to enter the shells, causing pod and seed rots (Figure 1). The …

Detecting And Managing Plant-Parasitic Nematodes On Soybean In South Carolina, Jonathan K. Croft, Kyle Smith, Shelby Hammond, Michael T. Plumblee, John D. Mueller

Soybeans

No abstract provided.

Final Project: Nutrition And Human Disease, Sam Newberry Ph.D.

School of Arts & Sciences

This assignment is made up of a series of smaller assignments that were developed by SUNY Geneseo Professor Sam Newberry during the spring 2026 semester.

Learning Objectives

• Identify and demonstrate understanding of audience needs
• Identify nutritional issues associated with human disease
• Clear communication of information via an Infographic
• Proper utilization of scholarly sources of information

Career Readiness In Developmental Biology Module, Travis Bailey Ph.D.

School of Arts & Sciences

This set of activities were developed and modified by SUNY Geneseo Professor Travis Bailey in the spring 2026 semester.

Biol 454: Developmental Biology (Syllabus), Travis Bailey Ph.D.

School of Arts & Sciences

This syllabus was developed by SUNY Geneseo Professor Travis Bailey in the spring 2026 semester.

Learning Outcomes-Students will:

• Understand the methods scientist use to explore the genetic, cellular, and tissue control of development.
• Compare and contrast developmental strategies of model organisms.
• Read primary literature critically and explain strengths and weaknesses.
• Test hypotheses with self-designed experimentation, measurement and data collection, evaluation of evidence, and employment of mathematical analysis.
• Relate discoveries from model animals to human conditions.
• Communicate findings orally and in writing.
• Integrate multiple bodies of knowledge with their personal experience by asking meaningful questions about real-world problems
• Apply skills, theories, …

Detecting And Managing Plant-Parasitic Nematodes In South Carolina Cotton, Kyle Smith, Rogan Gibson, Shelby Hammond, Jonathan Croft, John Mueller

Cotton

No abstract provided.

Detecting And Managing Plant-Parasitic Nematodes On Corn In South Carolina, Jay Crouch, Alex Coleman, Shelby Hammond, Michael T. Plumblee, John Mueller

Corn

No abstract provided.

Introduction To The Plant-Parasitic Nematodes Affecting Row Crops In South Carolina, Jonathan K. Croft, G. Kyle Smith, Jay Crouch, William J. Hardy Iii, Shelby Hammond, John D. Mueller

Introductory Materials

Knowledge of the biology, host range, overwintering habits, damage thresholds, and life cycles of problem nematode species is necessary to optimize the design of effective management schemes. The following is a summary of the relevant facts for the important plant-parasitic nematode species affecting South Carolina row crops.

Symptom Identification And Sampling Methods For Nematodes In South Carolina, Rogan Gibson, Zachary Dantzler, Joe Varn, Shelby Hammond, Hannah Watts Mikell, John Mueller

Introductory Materials

No abstract provided.

Detecting And Managing Plant-Parasitic Nematodes On Grain Sorghum In South Carolina, Alex Coleman, Michael Marshall, Jay Crouch, David Dewitt, Shelby Hammond, John Mueller

Grain Sorghum

Several species of nematodes can infect and reproduce on grain sorghum. However, unlike damage to cotton or soybeans, damage to grain sorghum is often minimal. This is because grain sorghum has a fibrous root system with multiple growing points, allowing it to rapidly compensate for damaged roots. Therefore, it can withstand higher nematode populations before exhibiting reduced plant growth or yield. Symptoms of nematode damage include stunting, nutrient deficiencies, and premature drought stress. Nematodes are not uniformly distributed in a field and symptoms of damage from nematodes are often more common in sandier areas of a field. Symptomatic plants have …

Testing The Intermediate Disturbance Hypothesis On Anthropogenic Pressure In Central Alabama, Gavin Terrell

Theses

Biodiversity is fundamental to maintaining ecosystem structure and function globally. Prior to the late 20th century, ecological theory generally predicted that biodiversity would be highest in systems experiencing minimal disturbance. However, Joseph H. Connell challenged this view with the Intermediate Disturbance Hypothesis (IDH), which posits that species diversity peaks at intermediate levels of disturbance and declines under conditions of both low and high disturbance. Although widely cited, the applicability of the IDH to natural systems remains debated, particularly in the context of anthropogenic disturbances and when diversity is measured beyond species richness alone.

This study evaluated the predictions of the …

Assessing The Influence Of Temperature And Water Level On Gill Disease In Goldfish, Moses Elijah Cadawas, Emmalie Turner, Darlene Panvini

SPARK Symposium Presentations

Gill disease in fish is a strong biological indicator of water quality and environmental stress. These diseases are commonly caused by bacterial or parasitic infections that target gill tissues and can lead to severe physiological impairment and ultimately mortality. Several environmental factors, including water level and temperature, play a critical role in determining fish susceptibility to these infections. Changes in these conditions can act as stressors that weaken immune defenses and promote pathogen proliferation. This study aimed to evaluate the relative impact of environmental stressors on the development of gill-associated disease in Carassius auratus (goldfish) under controlled conditions. Following exposure …

Assessment Of Precision Rangeland Management Tools In The Nebraska Sandhills, Hannah K. Allen

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

The objective of this thesis is to evaluate tools and management strategies that contribute to rangeland monitoring and livestock distribution in heterogeneous grassland systems of the Nebraska Sandhills. Chapter one reviews relevant literature related to precision livestock management, the Nebraska Sandhills, biomass estimation, and pyric herbivory. The second chapter evaluates the use of fractional green canopy cover (FGCC) derived from the Canopeo mobile application as a rapid method for estimating aboveground biomass in Sandhills rangelands. Biomass samples were collected across topographic positions in both early and late growing season, and relationships between FGCC and clipped biomass were assessed using generalized …

Fisheries Management Paper No.312: Discussion Paper On Management And Licensing Options For The Charter Industry - Statewide Strategic Review Of Western Australia’S Charter Fishing Sector, Department Of Primary Industries And Regional Development, Western Australia

Fisheries Management Papers

This consultation paper has been prepared to support the statewide strategic review of Western Australia’s (WA) charter fishing sector, which was initiated as a government commitment.

The paper details issues and proposals relating to the management and licensing framework, development opportunities and representation model for the charter fishing industry. The proposals have been developed in consultation with the Charter Review Working Group. The Department of Primary Industries and Regional Development (DPIRD) now seeks comment from relevant stakeholders on the issues and proposals outlined within this paper.

Comments provided will assist in providing advice and recommendations to the Minister for Fisheries …

Wright State University's Celebration Of Student Research, Scholarship & Creative Activities From Wednesday, April 1, 2026, Wright State University

Celebration of Undergraduate & Graduate Research, Scholarship, and Creative Activities Materials

The student abstract booklet is a compilation of abstracts from students' oral and poster presentations at Wright State University's Celebration of Student Research, Scholarship & Creative Activities on April 1, 2026.